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World J Clin Cases 2022 May;10(13):4064-4071

Department of Orthopedics, Taizhou Luqiao Second People's Hospital, Taizhou 318000, Zhejiang Province, China.

Background: Lower extremity fractures are mainly treated by surgical reduction, but this operation is often affected by the patient's level of agitation and the type of anesthesia used. The main treatment for lower-extremity fractures is operative reduction. However, operations can often be affected by both agitation and the degree of anesthesia. Read More

J Clin Orthop Trauma 2022 May 25;28:101848. Epub 2022 Mar 25.

Department of Orthopedics, The Ohio State Wexner Medical Center, Columbus, OH, USA.

Background: We sought to determine whether regional nerve block, cryotherapy variant, or patient-specific factors predict postoperative opioid requirements and pain control following hip arthroscopy.

Methods: 104 patients underwent hip arthroscopy with (n = 31) or without (n = 73) regional block and received cryotherapy with a universal pad [joint non-specific; no compression (n = 60)] or circumferential hip/groin wrap with intermittent compression (n = 44). Outcomes included total opioid prescription amounts, requests for refills, and unplanned clinical encounters for postoperative pain within 45 days of surgery. Read More

Am J Transl Res 2022 15;14(2):1076-1083. Epub 2022 Feb 15.

Faculty of Anesthesiology, Changhai Hospital Affiliated to The Navy Military Medical University Shanghai 200433, China.

Objective: This study was to compare the efficacy of femoral nerve block (FNB) and acupuncture for acute preoperative pain in patients with femoral neck fracture (FNF).

Methods: From June 2017 to June 2019, 130 patients with FNF were included in this study. Sixty-six patients received FNB treatment (FNB group) and sixty-four patients received acupuncture treatment (Acupuncture group). Read More

BMC Anesthesiol 2022 02 26;22(1):54. Epub 2022 Feb 26.

Department of Anesthesiology, Fengdu People's Hospital, No. 33, Lutang Street, Sanhe Street, 408200, Fengdu County, Chongqing, China.

Objective: To explore the analgesic effects of different concentrations of ropivacaine in transversalis fascia plane (TFP) block during laparotomy.

Methods: Ninety patients who underwent laparotomy admitted to our hospital from March 2019 to March 2020 were selected as the study subjects and were divided equally into a low concentration group, a medium concentration group, and a high concentration group according to the randomized grouping method. The low concentration group adopted 0. Read More

Brain Res Bull 2022 05 11;182:44-56. Epub 2022 Feb 11.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

Depression is the most common mental disorder and a leading cause of disability worldwide. Despite abundant research, the precise mechanisms underlying the pathophysiology of depression remain elusive. Accumulating evidence from preclinical and clinical studies suggests that alterations in the gut microbiota, microbe-derived short-chain fatty acids, D-amino acids and metabolites play a key role in the pathophysiology of depression via the brain-gut-microbiota axis, including the neural and immune systems. Read More

Medicine (Baltimore) 2022 Feb;101(5):e25131

Department of Orthopedic Surgery, College of Medicine, Daegu Catholic University, Daegu, Korea.

Abstract: It is hypothesized that if it is confirmed that the pain caused by the injection needle coincides with the lower leg radiating pain(LLRP) that the patient mainly complains of, then the contrast agents may be used less. This study aims to understand if the identification of lancinating identical pain in the procedure could replace the use of contrast agents that causes additional pain provocation using control arm of randomized clinical trial.This retrospective study included 165 patients who met exclusion criteria from among patients who underwent Selective nerve root block for the treatment of LLRP. Read More

Pain Physician 2022 01;25(1):77-85

Vice Chair for Research and Education, Department of Anesthesiology and Pain Management, Advocate Illinois Masonic Medical Center, Clinical Associate Professor of Anesthesiology and Surgery at University of Illinois, Chicago, IL.

Background: Post-traumatic stress disorder (PTSD) is a prevalent and debilitating condition in the United States. Success rates for evidence-based therapies are inconsistent, and many suffer in silence due to the stigmata associated with seeking traditional mental health care. This has led clinicians to explore new therapeutic options, with cervical sympathetic blockade (CSB), performed at the stellate and/or superior cervical ganglion levels, recently emerging as a promising treatment option. Read More

J Oral Maxillofac Surg 2022 Mar 10;80(3):490-500. Epub 2021 Oct 10.

Private Practice, Master Degree in Biotechnology and Bioengineering in Bioengineering Institute, Miguel Hernández University of Elche, Spain. Electronic address:

Purpose: There is no agreement in the literature on whether inferior alveolar nerve block (IANB) or infiltration (INF) is the anesthetic technique of choice for placing implants in the posterior mandible. This study aimed to compare the efficacy of the 2 techniques using articaine 4% with epinephrine 1:100,000.

Material And Methods: The trial was a comparison between 2 parallel groups of patients, who received implants distal to the mental foramen, either with IANB or INF. Read More

Clin J Pain 2021 12;37(12):881-886

Department of Anesthesiology, Second Affiliated Hospital of Naval Medical University.

Objectives: The aim was to compare the feasibility of ultrasound-guided multiple nerve blocks (fascia iliaca compartment block+sacral plexus block+superior cluneal nerve block) with general anesthesia in geriatric hip fracture patients.

Methods: Ninety-four patients were randomly divided into 2 groups: group N received ultrasound-guided multiple nerve blocks and group G received general anesthesia. Primary outcome measures included perioperative Pain Threshold Index (PTI) and Numerical Rating Scale. Read More

Int J Pharm 2021 Nov 16;609:121197. Epub 2021 Oct 16.

College of Dental Medicine, QU Health, Qatar University, Doha, Qatar. Electronic address:

The present study aimed to optimize Needle-Free Liquid Jet Injection (NFLJI) for Mental Incisive Nerve Blocks (MINB) and evaluate its clinical safety and feasibility. A MINB protocol was developed and optimized by series of NFLJI experiments in soft tissue phantoms and cadavers, then validated in two pilot Randomized Controlled Trials (RCT). The NFLJI penetration depth was found to be directly proportional to the supply pressure and volume. Read More

Pain Pract 2022 03 29;22(3):329-339. Epub 2021 Oct 29.

Clinic of Anaesthesiology and Intensive Care Medicine, Pain Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Objective: Ultrasound-guided stellate ganglion block (usSGB) facilitates improved accuracy of needle position and application of lesser volumes of local anesthetic (LA). Approaches of usSGB, however, have not fully been optimized with respect to efficacy and technical convenience. This pilot study examined the anatomical position and spatial distribution of a small volume of LA injectate dispensed by medial transthyroid usSGB via magnetic resonance imaging (MRI) and assessment of its effect on cervical sympathetic nerves. Read More

J Oral Maxillofac Surg 2022 Feb 28;80(2):266.e1-266.e8. Epub 2021 Aug 28.

Professor, Department Head, Department of Dental Anesthesiology, Kanagawa Dental University, Yokosuka, Japan.

Purpose: Although a stellate ganglion block (SGB) increases tissue blood flow in the mandibular region, the change in tissue oxygenation after SGB and therapeutic effect of SGB for postoperative mandibular nerve hypoesthesia remain to be established. The study aim was to measure the change in tissue oxygenation in the mandibular region after SGB.

Methods: To determine the variation in tissue oxygenation in the mandibular region, the tissue oxygen index (TOI; percentage of oxygenated hemoglobin in the total hemoglobin) was measured at the skin near the mental foramen bilaterally, at the primary site of unilateral SGB, achieved using 6 mL of 1% lidocaine hydrochloride, for the treatment of bilateral postoperative mandibular nerve injury. Read More

Pharmaceuticals (Basel) 2021 Sep 9;14(9). Epub 2021 Sep 9.

Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology and Neuroscience, Guy's Campus, King's College London, London SE1 1UL, UK.

Oligodendrocytes produce myelin, which provides insulation to axons and speeds up neuronal transmission. In ischaemic conditions, myelin is damaged, resulting in mental and physical disabilities. Recent evidence suggests that oligodendrocyte damage during ischaemia can be mediated by Transient Receptor Potential Ankyrin-1 (TRPA1), whose activation raises intracellular Ca concentrations and damages compact myelin. Read More

J Dent (Shiraz) 2021 Sep;22(3):213-218

Dept. of Oral and Maxillofacial Radiology, School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Statement Of The Problem: The inferior alveolar canal (IAC) is a bony canal that starts from mandibular foramen at the inner surface of the mandibular ramus and extends along the ramus and body of mandibular bone in forward and downward directions to the mental foramen. Inside the mandibular canal, there are lower alveolar artery and a nerve with the same name. Understanding the anatomical details of the lower alveolar canal, including position, pathway and morphology to prevent complications in surgical procedures in the lower jaw such as mandibular impacted molar surgeries, mandibular nerve block injection, or even root canal treatment of mandibular teeth is important. Read More

Neuroimage 2021 11 5;243:118532. Epub 2021 Sep 5.

Institute of Neuroscience, Université catholique de Louvain, Brussels 1200, Belgium; Univ. Bordeaux, CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France. Electronic address:

Long-lasting and demanding cognitive activity typically leads to mental fatigue (MF). Indirect evidence suggests that MF may be caused by altered motivational processes. Here, we hypothesized that if MF consists in an alteration of motivational states, brain functional changes induced by MF could specifically affect the brain motivation circuit. Read More

Spine (Phila Pa 1976) 2022 May 30;47(9):666-671. Epub 2021 Aug 30.

Department of Orthopaedic Surgery, Daegu Fatima Hospital, Daegu, South Korea.

Study Design: Retrospective study of data collected prospectively.

Objective: To investigate changes in the degree of lower leg radiating pain (LLRP) after selective nerve root block (SNRB) and to evaluate associations of this change with postoperative improvements in symptom severity, functional outcomes, and quality of life.

Summary Of Background Data: SNRB is routinely performed as an initial treatment for lumbar foraminal or lateral recess stenosis with LLRP. Read More

Am J Transl Res 2021 15;13(7):7976-7982. Epub 2021 Jul 15.

Department of Anesthesiology, Sanya People's Hospital Sanya 572000, Hainan Province, China.

Objective: To explore the effect and complications of esketamine combined with ultrasound-guided nerve block in children with lower extremity fractures.

Methods: 120 children with fractures of lower extremities were included into the observation group (OG) and control group (CG) according to the specific anesthesia method. The OG was given esketamine combined with ultrasound-guided nerve block, and the CG was given ultrasound-guided nerve block combined with general anesthesia. Read More

J Pain Res 2021 19;14:2201-2208. Epub 2021 Jul 19.

Department of Pain Medicine, First Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.

Purpose: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Read More

Can J Anaesth 2021 11 21;68(11):1690-1694. Epub 2021 Jul 21.

Department of Anesthesia and Pain Medicine, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.

Purpose: Chronic scrotal content pain, chronic orchialgia, or testicular pain can present after trauma, vasectomy, and hernia repair, among other triggers. Microsurgical denervation of the spermatic cord is an option for definitive pain control. While this practice is established in adult urology, access to diagnostic intervention and definitive denervation surgery is limited in the pediatric population. Read More

Zhonghua Yi Xue Za Zhi 2021 Jul;101(25):1968-1972

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

To investigate the impact of ultrasound-guided lumbar plexus, sciatic nerve and L paravertebral combined nerve blocks on the outcomes of elderly acute cerebral infarction patients with femoral neck fracture who underwent hip replacement. The clinical data of 114 elderly acute cerebral infarction patients with femoral neck fracture and underwent artificial hip replacement surgery from May 2013 to September 2018 in Renmin Hospital of Wuhan University were retrospectively analyzed. The patients were divided into two groups based on the different anesthetic methods they received: general anesthesia (G group, =48), lumbar plexus, sciatic nerve and L paravertebral combined nerve blocks (N group, =66). Read More

J Minim Invasive Gynecol 2021 10 26;28(10):1681-1684. Epub 2021 May 26.

Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Tongji University, and Institute of Gynecological Minimally Invasive Medicine, Tongji University School of Medicine, Shanghai, China (all authors).. Electronic address:

Objective: Adenomyosis usually causes dysmenorrhea and anemia. Clinically, it is difficult to be treated with medicine or by traditional surgery, however, hysterectomy is always performed for radical treatment. In this article, we introduce a new method that could control the dysmenorrhea and the anemia through laparoscopic uterine artery occlusion (LUAO) combined with uterine-sparing pelvic plexus block and partial adenomyomectomy for uterus preservation. Read More

Am J Transl Res 2021 15;13(4):3174-3181. Epub 2021 Apr 15.

Department of Anesthesiology, Hainan General Hospital Haikou 570000, Hainan Province, China.

Objective: The purpose of this study was to compare the effects of continuous intravenous infusions (CII) of fentanyl by pumping and ultrasound-guided continuous femoral nerve block (CFNB) with ropivacaine in terms of analgesic effects and postoperative cognitive function following total knee arthroplasty.

Methods: The clinical data of 103 patients who underwent total knee arthroplasty were collected retrospectively and divided into group A (n = 51) receiving CII of fentanyl by pumping and group B (n = 52) receiving CFNB with ropivacaine. Mini-Mental State Examination (MMSE) scores, Visual analog scale (VAS) scores, knee joint flexion angle (KJFA), muscle strength, postoperative cognitive dysfunction (POCD), patient satisfaction, and adverse reactions of the two groups were compared. Read More

Neurol India 2021 Mar-Apr;69(2):487-489

Department of Neuroanesthesia and Neurocritical Care, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Erector spinae plane (ESP) block is a recently introduced regional technique for pain management. However, its usefulness for perioperative analgesia in cervical and thoracic spine surgeries is underutilized. In this case series, we reviewed the case records of seven patients who received ultrasound-guided ESP block for perioperative analgesia for cervical and thoracic spine surgeries during a two-month period. Read More

J Clin Anesth 2021 Sep 23;72:110299. Epub 2021 Apr 23.

Chief of Department of Anesthesia, Lincoln Medical & Mental Health Center, United States.

Harefuah 2021 Apr;160(4):245-249

Hypertension Unit, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel.

Introduction: Pseudopheochromocytoma is an uncommon form of hypertension. In contrast to the more well-known pheochromocytoma, no unequivocal etiologic factor or a clear physiological abnormality can be identified. This disorder manifests in sudden, recurrent, episodes of significant, sometimes extreme, increase in blood pressure, both systolic and diastolic, lasting from minutes to hours, with no consistent trigger that the patient or the doctor is aware of, and is accompanied by typical symptoms. Read More

Pain Pract 2021 09 30;21(7):785-793. Epub 2021 Apr 30.

Department of Orthopaedic Surgery, College of Medicine, Daegu Catholic University, Daegu City, Korea.

Background: Selective nerve root block (SNRB) was shown to effectively control radiating pain and reduce the need for surgical intervention. However, repetitive injections may trigger corticosteroid-induced side effects (hypercorticism, hyperglycemia, or fluid retention). This study aims to compare the potency of hyaluronic acid-carboxymethylcellulose (HA-CMC) solution versus that of corticosteroids regarding lower leg radiating pain (LLRP) improvement and functional outcome. Read More

PLoS One 2021 3;16(3):e0238670. Epub 2021 Mar 3.

Department of Behavioural Sciences, Medical School, University of Pécs, Pécs, Hungary.

Heart Rate Variability (HRV) has been suggested as a useful tool to assess fatigue-sensitive psychological operations. The present study uses a between and within-subject design with a cognitively demanding task and a documentary viewing condition, to examine the temporal profile of HRV during reactivity, Time-on-Task (ToT), and recovery. In the cognitive task group, participants worked on a bimodal 2-back task with a game-like character (the Gatekeeper task) for about 1. Read More

Brain Imaging Behav 2021 Oct 26;15(5):2317-2329. Epub 2021 Jan 26.

FIDMAG Germanes Hospitalàries Research Foundation, Dr Pujadas, 38, 08830, Sant Boi de Llobregat, Barcelona, Spain.

The Computerised Multiple Elements Test (CMET) is a novel executive task to assess goal management and maintenance suitable for use within the fMRI environment. Unlike classical executive paradigms, it resembles neuropsychological multi-elements tests that capture goal management in a more ecological way, by requiring the participant to switch between four simple games within a specified time period. The present study aims to evaluate an fMRI version of the CMET and examine its brain correlates. Read More

Headache 2021 02 12;61(2):392-395. Epub 2021 Jan 12.

Department of Neurology, Centro Hospitalar Universitário de São João, E.P.E., Porto, Portugal.

Objectives/background: Auriculotemporal neuralgia is a rare headache disorder. Anesthetic nerve blockade seems to be effective in most cases; however, literature is scarce about the management of refractory cases.

Methods: Case report. Read More

Surg Neurol Int 2020 22;11:455. Epub 2020 Dec 22.

Department of Radiotherapy, Postgraduate Institute of Medical Education and Reserach, Chandigarh, India.

Background: The correct diagnosis of trigeminal neuralgia (TN) is still a far cry and the patients suffer from unnecessary dental procedures before getting the definite treatment. In this study, we evaluated, if the patients have undergone dental procedures for their misdiagnosed TN before receiving definite treatment for the same.

Methods: A total of 187 patients received GKRS for their TN (excluding secondary TN) in two institutes from 2010 to 2019. Read More