Search Our Scientific Publications & Authors

J Audiol Otol 2021 Jun 25. Epub 2021 Jun 25.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, Korea.

We report a case of a pseudoaneurysm secondary to skull base osteomyelitis (SBO) in an 82-year-old female. The patient was hospitalized with an acute episode of bleeding from the right ear, which persisted despite packing placed in the ear. We suspected bleeding from the internal carotid artery (ICA) and performed angiography, which revealed a pseudoaneurysm that presumably developed secondary to invasion of the wall of the petrous segment of the right ICA, and the patient underwent emergency coil embolization. Read More

Auton Neurosci 2021 Jun 20;234:102835. Epub 2021 Jun 20.

Department of Neurology, RWTH Aachen University, Pauwels Street 30, 52074 Aachen, Germany. Electronic address:

Objectives: Vagus nerve (VN) has been suggested as one of the major routes of Parkinson's disease (PD) progression from enteric nervous system to brain. Therefore, the recent studies have investigated the VN structurally, with a focus on the changes in its size in PD patients using high-frequency ultrasonography. This systematic review and meta-analysis aims to evaluate VN size via ultrasound in PD compared to controls. Read More

Sleep Med Rev 2021 Jun 5;58:101513. Epub 2021 Jun 5.

Department of Pulmonary Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

This systematic review summarizes the prevalence of treatment-emergent central sleep apnea (TECSA) occurring with therapies other than positive airway pressure (PAP) for the management of obstructive sleep apnea (OSA). We describe its natural course as well as the proposed underlying pathophysiological mechanisms and the clinical management of affected patients. A systematic search of PubMed, Embase, Web of science, and the Cochrane Library was performed until June 2020. Read More

Nutrition 2021 May 21;89:111346. Epub 2021 May 21.

Urology Division, Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Objectives: The aim of this study was to investigate the effects of diet reversal to standard chow on diet-induced changes in structure and function of normal and obstructed bladders in male Wistar rats.

Methods: Eighty animals were equally divided into sham-surgery and bladder outlet obstruction (BOO) dietary groups and fed standard chow (control), high-carbohydrate, high-fat, and high-protein diets. BOO groups had surgically induced BOO, whereas sham surgery was performed on sham groups at the end of week 8. Read More

Neuroimage Clin 2021 Jun 17;31:102732. Epub 2021 Jun 17.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

Objective: To prospectively determine whether diffusion basis spectrum imaging (DBSI) detects, differentiates and quantitates coexisting inflammation, demyelination, axonal injury and axon loss in mice with optic neuritis (ON) due to experimental autoimmune encephalomyelitis (EAE), and to determine if DBSI accurately measures effects of fingolimod on underlying pathology.

Methods: EAE was induced in 7-week-old C57BL/6 female mice. Visual acuity (VA) was assessed daily to detect onset of ON after which daily oral-treatment with either fingolimod (1 mg/kg) or saline was given for ten weeks. Read More

J Clin Anesth 2021 Jun 21;74:110401. Epub 2021 Jun 21.

Consultant, Department of Anaesthesia, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Honorary Senior Lecturer, King's College London, London, United Kingdom.

Hand Surg Rehabil 2021 Jun 21. Epub 2021 Jun 21.

Antalya Training and Research Hospital, Department of Orthopedics and Traumatology, Soguksu district, Kazım Karabekir street, Muratpasa, 07100, Antalya, Turkey. Electronic address:

This study aimed to evaluate the effectiveness of the WALANT technique in managing spaghetti wrist lacerations. Thirteen consecutive patients with spaghetti wrist laceration were operated on under WALANT and followed prospectively. All patients were operated on by the same hand surgeon in a university hospital setting. Read More

J Neurosci Methods 2021 Jun 21:109266. Epub 2021 Jun 21.

School of Optometry, University of California, Berkeley, CA 94720, USA; Graduate Program in Vision Science, University of California, Berkeley, CA 94720, USA.

Background: The tortuosity of nerve fibers has been shown to be important for identifying and monitoring clinically relevant manifestations resulting from of a variety of ocular and systemic disease pathologies and disorders. However, quantifying tortuosity in dense neurite networks can prove challenging, as existing methods require manual scoring and/or complete segmentation of the neurite network.

New Method: We measured neurite tortuosity by quantifying the degree of directional coherence in the Fourier transform of segmented neurite masks. Read More

Eur J Neurol 2021 Jun 24. Epub 2021 Jun 24.

Department of Radiology & Tianjin Key Lab of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.

Background: Leber's hereditary optic neuropathy (LHON) is a disease maternally inherited from mitochondria that predominantly impairs the retinal ganglion cells and their axons. To identify whether occult brain white matter (WM) impairment is involved, a voxel-based analysis (VBA) of diffusion metrics was carried out in LHON patients with normal-appearing brain parenchyma.

Methods: Fifty-four symptomatic LHON patients (including 22 acute LHON with vision loss <= 12 months, and 32 chronic LHON) without any visible brain lesions and 36 healthy controls (HC) were enrolled in this study. Read More

PLoS One 2021 24;16(6):e0253323. Epub 2021 Jun 24.

Byers Eye Institute, Stanford University, Palo Alto, California, United States of America.

Purpose: To evaluate the ability of confocal near-infrared reflectance (NIR) to diagnose retrograde microcystic maculopathy (RMM) in eyes with temporal visual field (VF) loss and optic atrophy from chiasmal compression. To compare NIR findings with optical coherence tomography (OCT) findings in the same group of patients.

Methods: Thirty-four eyes (26 patients) with temporal VF loss from chiasmal compression and 41 healthy eyes (22 controls) underwent NIR fundus photography, and macular OCT scanning. Read More

Angiol Sosud Khir 2021 ;27(2):32-40

Cardiovascular Surgery Department, People's Friendship University of Russia, Moscow, Russia.

The article is a review of contemporary randomized studies on radiofrequency denervation of renal arteries, followed by critical assessment of their advantages and disadvantages for possible optimization of endovascular treatment of resistant arterial hypertension. Read More

Pain 2021 Jun 23. Epub 2021 Jun 23.

Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany Research group Neuroscience, Interdisciplinary Centre for Clinical Research within the faculty of Medicine at the RWTH Aachen University, Aachen, Germany.

Abstract: Lysophosphatidic acid (LPA) is involved in the pathophysiology of cholestatic pruritus and neuropathic pain. Slowly conducting peripheral afferent C-nerve fibers are crucial in the sensations of itch and pain. In animal studies, specialized neurons ("pruriceptors") have been described, expressing specific receptors e. Read More

JBJS Case Connect 2021 Jun 24;11(2). Epub 2021 Jun 24.

Department of Anesthesiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.

Case: An elderly, polytrauma patient receiving vitamin K antagonist (VKA) for atrial fibrillation required immediate surgery for open distal tibial fracture. As the initial reversal with vitamin K and fresh frozen plasma by the trauma team was ineffective, the "Bleeding Team" was convened and administrated the appropriate four-factor prothrombin complex regimen, reversing the VKA in a timely manner. Surgery was performed under peripheral nerve blockade subsequently. Read More

A A Pract 2021 Jun 24;15(7):e01492. Epub 2021 Jun 24.

From the Department of Anesthesiology, Division of Pain Medicine.

Angiomyomatous hamartomas are mixed-tissue benign lymphatic tumors that typically occur in the inguinal or axillary lymph nodes. These lesions may cause local lymphedema and painful compression neuralgias. Ultrasound-guided percutaneous cryoablation is an interventional technique that has been shown to provide sustained pain relief for peripheral neuropathies and neuralgias. Read More

J Appl Physiol (1985) 2021 Jun 24. Epub 2021 Jun 24.

School of Sport, Exercise and Health Sciences, grid.6571.5Loughborough University, Leicestershire, United Kingdom.

This study compared elbow flexor (EF; Experiment 1) and knee extensor (KE; Experiment 2) maximal compound action potential (M) amplitude between long-term resistance trained (LTRT; n=15 and n=14, 6±3 and 4±1 years of training) and untrained (UT; n=14 and n=49) men; and examined the effect of normalising electromyography (EMG) during maximal voluntary torque (MVT) production to M amplitude on differences between LTRT and UT. EMG was recorded from multiple sites and muscles of EF and KE, M was evoked with percutaneous nerve stimulation, and muscle size was assessed with ultrasonography (thickness, EF) and magnetic resonance imaging (cross-sectional area, KE). Muscle-electrode distance (MED) was measured to account for the effect of adipose tissue on EMG and M. Read More

Head Neck 2021 Jun 24. Epub 2021 Jun 24.

Department of Otolaryngology-Head and Neck Surgery, The James Cancer Hospital, Wexner Medical Center, The Ohio State University, Columbus, Ohio, USA.

Lesions arising from the upper parapharyngeal space (UPPS) often involved the jugular foramen region (JFR), occasionally extending into the posterior cranial fossa. This study aims to investigate the surgical anatomy of the JFR and UPPS from the perspective of an expanded endoscopic approach (EEA), tracing the lower cranial nerves from their extracranial foramina to the UPPS. Six cadaveric specimens (12 sides) underwent a transpterygoid EEA to expose the JFR and UPPS. Read More

Glia 2021 Jun 24. Epub 2021 Jun 24.

Department of Anatomy and Neuroscience, Nara Medical University, Kashihara, Japan.

Single oligodendrocytes produce myelin sheaths around multiple axons in the central nervous system. Interfascicular oligodendrocytes (IOs) facilitate nerve conduction, but their detailed morphologies remain largely unknown. In the present study, we three-dimensionally reconstructed IOs in the corpus callosum of adult mouse using serial block face scanning electron microscopy. Read More

Pain Ther 2021 Jun 24. Epub 2021 Jun 24.

University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Read More

Arch Orthop Trauma Surg 2021 Jun 24. Epub 2021 Jun 24.

Department of Orthopaedics, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, No 208 Huancheng East Rd, Zhejiang Province, Hangzhou, 310003, China.

Background: Due to the complexity of the anatomical structure and the difficulty of exposing the surgical area, the surgery for spinal tuberculosis in the upper thoracic vertebra (above T6-T7) is complicated and the prognosis is not good. This study aimed to investigate the clinical effects of posterolateral costotransversectomy using an extrapleural approach in patients with upper thoracic spinal tuberculosis.

Methods: This was a retrospective analysis of 132 patients (including 78 males and 54 females) with upper thoracic spinal tuberculosis who underwent one-stage internal fixation and debridement followed by combined interbody and posterior fusion via posterolateral costotransversectomy using an extrapleural approach. Read More

JAMA Otolaryngol Head Neck Surg 2021 Jun 24. Epub 2021 Jun 24.

Department of Ophthalmology, Shamir Medical Center, Be'er Ya'akov, Israel.

Importance: Peripheral facial nerve (Bell) palsy has been reported and widely suggested as a possible adverse effect of the BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine. Israel is currently the leading country in vaccination rates per capita, exclusively using the BNT162b2 vaccine, and all residents of Israel are obligatory members of a national digital health registry system. These factors enable early analysis of adverse events. Read More

J Clin Sleep Med 2021 May 3. Epub 2021 May 3.

Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, MA.

None: Treatment emergent central sleep apnea (TECSA) can occur with positive airway pressure (PAP) therapy, mandibular advancement devices, and now recent cases with hypoglossal nerve stimulator (HNS) therapy during treatment for obstructive sleep apnea (OSA). There have been few published reports of Cheyne-Stokes breathing (CSB) emerging after implantation of a hypoglossal nerve stimulator (HNS). We present a case of a 76-year-old male with chronic atrial fibrillation and OSA who developed significant CSB after implantation of a HNS device. Read More

Acta Neurochir (Wien) 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.

Introduction: The diagnosis of Chiari I malformation, its symptomatology, and the results of its surgical management are still discussed. We report a pediatric series of CMI without associated skull base malformations or cerebellar growth anomalies operated between 2001 and 2018.

Material And Methods: Ninety-one children out of 146 surgically treated cases have been included in the study. Read More

Oper Neurosurg (Hagerstown) 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Oper Neurosurg (Hagerstown) 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery, University of Washington, Seattle, Washington, USA.

A 62-yr-old man with left cavernous sinus tumor presented with atypical trigeminal neuralgia refractory to medical treatment. He received Gamma Knife (Elekta) radiation for the tumor. However, the facial pain worsened after radiation. Read More

Ann Transl Med 2021 May;9(10):881

Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, China.

Background: Spinal cord injury (SCI) is a traumatic disease that is associated with high morbidity, disability, and mortality worldwide. The animal spinal cord contusion model is similar to clinical SCI; therefore, this model is often used to study the pathophysiological changes and treatment strategies for humans after SCI. The present study aimed to introduce a novel, minimally invasive technique to establish an SCI model, and to evaluate its advantages compared with conventional methods. Read More

Gland Surg 2021 May;10(5):1786-1791

Department of Otolaryngology, Head & Neck Surgery, Peking University First Hospital, Beijing, China.

Aberrant extracranial internal carotid artery and nonrecurrent laryngeal nerve (NRLN) are neurovascular anomalies, which clinicians should be aware of to prevent severe complications while performing transoral or open surgery in the head and neck area. These two variants can occur simultaneously because of similar etiology of embryological maldevelopment of arch arteries. In this study, a 64-year-old woman complaining of hoarseness presented a bulge in the left hypopharynx. Read More

Gland Surg 2021 May;10(5):1756-1766

Department of Head and Neck Surgery, Sichuan Cancer Hospital, Sichuan Cancer Institute, Sichuan Cancer Prevention and Treatment Center, Cancer Hospital of University of Electronic Science and Technology School of Medicine, Chengdu, China.

The past decade has witnessed rapid advances in gasless transaxillary endoscopic thyroidectomy (GTET) for thyroid cancer, which has become a reliable procedure with good therapeutic effectiveness, aesthetic benefits, and safety. This procedure has been widely promoted in some Asian countries; however, few studies have described the specific surgical steps for unilateral low-risk thyroid cancer. Based on a review of the literature and our own clinical experience, we introduce in detail the surgical procedure of GTET for the unilateral low-risk thyroid cancer, briefly summarized into Li's 6 steps: surgical position and incision design; creation of surgical cavities; dissection of the superior pole of the thyroid and its vessels, and identification and protection of superior laryngeal nerve; identification and protection of the superior parathyroid gland, and identification of the inferior parathyroid gland; identification and protection of the recurrent laryngeal nerve and the inferior parathyroid gland, and central neck dissection; and processing of the suspensory ligaments of thyroid gland and resection of the tumor. Read More

Gland Surg 2021 May;10(5):1576-1586

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Parathyroidectomy under nerve monitoring has been carried out for nearly ten years in the China-Japan Union Hospital of Jilin University. We retrospectively evaluated patients' prognosis with secondary hyperparathyroidism (SH) under neuro- and non-neuro-monitored parathyroidectomy anesthesia. The purpose of this study is to summarize and introduce a new anesthesia scheme for parathyroidectomy under nerve monitoring. Read More

Gland Surg 2021 May;10(5):1554-1563

Center for Thyroid and Breast Surgery, Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Background: The lymph nodes in the right central compartment can be divided into 2 parts by the right recurrent laryngeal nerve (RLN), and there is a lack of an accurate and convenient method for assessing metastases in the lymph node posterior to the right recurrent laryngeal nerve (LN-prRLN) in cN0 thyroid papillary carcinoma patients.

Methods: Patients diagnosed with cN0 thyroid papillary carcinoma and underwent intraoperative carbon nanoparticle-guided lymph node biopsy from January 2017 to November 2020 at the Center for Thyroid and Breast Surgery of Xuanwu Hospital were retrospectively analyzed. The intraoperative frozen section examination and postoperative LN-prRLN status should have been comprehensively recorded. Read More