Diabetologia 2013 Mar 13;56(3):467-75. Epub 2012 Dec 13.
Diabetes & Endocrinology Unit, Department of Internal Medicine, San Raffaele Hospital and San Raffaele Vita Salute University, Via Olgettina 60, 20132 Milan, Italy.
Aims/hypothesis: The aim was to evaluate the efficacy and safety of transcutaneous frequency-modulated electromagnetic neural stimulation (frequency rhythmic electrical modulation system, FREMS) as a treatment for symptomatic peripheral neuropathy in patients with diabetes mellitus.
Methods: This was a double-blind, randomised, multicentre, parallel-group study of three series, each of ten treatment sessions of FREMS or placebo administered within 3 weeks, 3 months apart, with an overall follow-up of about 51 weeks. The primary endpoint was the change in nerve conduction velocity (NCV) of deep peroneal, tibial and sural nerves. Read More