23,692 results match your criteria Nephrotic Syndrome

Successful Reuse of Kidney Graft After Early Recurrence of Primary Focal and Segmental Glomerulosclerosis.

Am J Kidney Dis 2021 Jun 9. Epub 2021 Jun 9.

Department of Nephrology, Dialysis, Transplantation, and Apheresis, Lille University, Regional and University Hospital Center of Lille, F-59037 Lille, France.

Primary focal and segmental glomerulosclerosis (pFSGS) frequently recurs after transplantation and is associated with a poor prognosis. We describe here the successful kidney graft reuse in an adult recipient, eight months after early pFSGS recurrence resistant to all available therapeutics. Patient 1, a 23-year-old man, followed for kidney failure secondary to pFSGS, was first transplanted in 2018 with a deceased donor graft. Read More

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The B-Natural study-The outcome of immune tolerance induction therapy in patients with severe haemophilia B.

Haemophilia 2021 Jun 12. Epub 2021 Jun 12.

Indiana Haemophilia and Thrombosis Centre, Indianapolis, Indiana, USA.

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher.

Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Read More

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Vaccines and Disease Relapses in Children with Nephrotic Syndrome.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):937-938. Epub 2021 Jun 11.

Division of Nephrology, Dialysis, and Transplantation, Instituto di ricovero e cura a carattere scientifico (IRRCS) Instituto Giannina Gaslini Children's Hospital, Genoa, Italy

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VEGF-VEGFR2 inhibitor-associated hyaline occlusive glomerular microangiopathy: a Japanese single-center experience.

Clin Exp Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.

Background: Inhibitors of vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling, such as bevacizumab (Bmab), are used for the treatment of various advanced cancers. However, these inhibitors induce renal thrombotic microangiopathy (TMA). Recently, two European cohort studies showed a distinctive histopathological pseudothrombotic pattern different from TMA in Bmab-treated patients. Read More

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Membranous Nephropathy With Monoclonal IgM Lambda Deposits in a Patient With IgM Monoclonal Gammopathy: A Case Report.

Front Med (Lausanne) 2021 25;8:608741. Epub 2021 May 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo, Japan.

We report a case of membranous nephropathy with monoclonal immunoglobulin (Ig)M lambda deposits in a patient with IgM monoclonal gammopathy, in whom histological changes were observed on repeat renal biopsy. A 72-year-old Japanese woman was referred to our hospital because of massive proteinuria. A prominent increase in monoclonal IgM lambda level was identified, and she was diagnosed as having IgM monoclonal gammopathy of undetermined significance. Read More

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Mitochondrial Complex I Deficiency among Egyptian Pediatric Patients with Steroid-Resistant Nephrotic Syndrome.

Int J Nephrol 2021 18;2021:6645373. Epub 2021 May 18.

Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

Results: Positive consanguinity was a remarkable finding in 44 patients among the SRNS group (73%), compared with 33 patients among the SSNS group (55%). Complex I activity was significantly lower in the SRNS group (0.2657 ± 0. Read More

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IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report.

Int Med Case Rep J 2021 3;14:377-380. Epub 2021 Jun 3.

Department of Medicine, Nephrology and Dialysis Unit, SS Annunziata Hospital, "G. d'Annunzio" University, Chieti, Italy.

Background: Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined.

Case Presentation: We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. Read More

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Use of rituximab in paediatric nephrology.

Arch Dis Child 2021 Jun 10. Epub 2021 Jun 10.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Rituximab is a chimeric monoclonal antibody capable of depleting B cell populations by targeting the CD20 antigen expressed on the cell surface. Its use in oncology, initially in B cell lymphoma and post-transplant lymphoproliferative disorders, predates its current utility in various fields of medicine wherein it has become one of the safest and most effective antibody-based therapies. It was subsequently found to be effective for rheumatological conditions such as rheumatoid arthritis and antineutrophil cytoplasmic antibody-associated vasculitis. Read More

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Abstracts of the 14 Asian Congress of Pediatric Nephrology, Taipei, Taiwan, March 2021.


Pediatr Nephrol 2021 Jun 9. Epub 2021 Jun 9.


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Two cases of secondary AA amyloidosis involving the skin and chronic kidney infection with a nephrotic syndrome in a high-income country.

BMJ Case Rep 2021 Jun 7;14(6). Epub 2021 Jun 7.

Nephrology Dialysis Apheresis, Hopital Universitaire de Nimes, CHU Caremeau, Nimes, France

We present two French cases of amyloid-associated (AA) amyloidosis secondary to chronic infections. Patient 1, a 51-year-old heroin addict, was hospitalised for chest pain and anasarca. During hospitalisation, a nephrotic syndrome with an inflammatory condition was discovered along with a chronic skin ulcer on his arm. Read More

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[Spontaneous intracranial hypotension: A rare cause of headache in systemic lupus erythematosus].

Rev Med Interne 2021 Jun 4. Epub 2021 Jun 4.

Service de médecine Interne, CHU de Caen Normandie, 14000 Caen, France.

Introduction: Spontaneous intracranial hypotension (SIH), a rare cause of headache, may be idiopathic or secondary, in particular to Systemic Lupus Erythematosus (SLE) where it remains exceptionally evoked or documented.

Case Report: A 36-year-old woman presented with postural headache, recurrent nausea and vomiting. The discovery of a nephrotic syndrome led to the diagnosis of SLE with lupus nephropathy (class IV-G-(A)). Read More

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Sex and kidney ACE2 expression in primary focal segmental glomerulosclerosis: A NEPTUNE study.

PLoS One 2021 7;16(6):e0252758. Epub 2021 Jun 7.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Background: Angiotensin-converting enzyme 2 (ACE2) has been implicated in the pathogenesis of experimental kidney disease. ACE2 is on the X chromosome, and in mice, deletion of ACE2 leads to the development of focal segmental glomerulosclerosis (FSGS). The relationship between sex and renal ACE2 expression in humans with kidney disease is a gap in current knowledge. Read More

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More than tubular dysfunction: cystinosis and kidney outcomes.

J Nephrol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pediatric Metabolism and Nutrition, Cukurova University Faculty of Medicine, Adana, Turkey.

Background: Cystinosis is a lysosomal storage disease that affects many tissues. Its prognosis depends predominantly on kidney involvement. Cystinosis has three clinical forms: nephropathic infantile, nephropathic juvenile and non-nephropathic adult. Read More

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Efficacy of a micronized, nanocrystal fenofibrate formulation in treatment of hyperlipidemia in dogs.

J Vet Intern Med 2021 Jun 6. Epub 2021 Jun 6.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, 1 Shields Ave., Davis, California 95616, USA.

Background: Safe, effective, and readily available drug therapies are required for the management of hyperlipidemia and its associated complications in dogs.

Objectives: To investigate the efficacy of a micronized, nanocrystal formulation of fenofibrate (Tricor) in the treatment of hyperlipidemia in dogs.

Animals: Ten client-owned dogs with primary (n = 7) and secondary (n = 3) hyperlipidemia. Read More

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Differences in Health-Related Quality of Life Among Adults with a Potential Dihydropyridine Calcium Channel Blocker-Loop Diuretic Prescribing Cascade.

Drugs Aging 2021 Jun 7. Epub 2021 Jun 7.

Department of Pharmaceutical Outcomes and Policy, University of Florida College of Pharmacy, 1225 Center Dr, Gainesville, FL, 32610, USA.

Background: Dihydropyridine calcium channel blockers (DH CCBs) are commonly used for hypertension in older adults. However, loop diuretics can be inappropriately added to treat DH CCB-induced edema, putting individuals at increased risk for adverse events and potential decreases in quality of life.

Methods: We conducted a cross-sectional analysis using United States Medical Expenditure Panel Survey (MEPS) data from 2003 to 2015. Read More

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Efficacy and safety of rituximab in adult frequent-relapsing or steroid-dependent minimal change disease or focal segmental glomerulosclerosis: a systematic review and meta-analysis.

Clin Kidney J 2021 Apr 21;14(4):1042-1054. Epub 2020 Nov 21.

Division of Nephrology, Kidney Institute of CPLA (Chinese People's Liberation Army), Changzheng Hospital, Second Military Medical University, Shanghai, China.

Background: The efficacy and safety of rituximab (RTX) in adult frequent-relapsing (FR) or steroid-dependent (SD) nephrotic syndrome (NS), including minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS), are still inconclusive.

Methods: We performed a systematic review and meta-analysis registered in  PROSPERO (CRD42019148102) by pooling data of cohort studies or case series on adult patients with difficult-to-treat NS. Steroid-resistant NS was excluded. Read More

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Meta-Analysis of Clinical Efficacy and Safety of Polyglycosides Tablets in the Treatment of Chronic Kidney Disease.

Evid Based Complement Alternat Med 2021 13;2021:6640594. Epub 2021 May 13.

The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Shaanxi 712000, China.

Objective: polyglycosides tablet (TGt) is an oral preparation extracted from plant . It has the effects of anti-inflammation and inhibition of cellular and humoral immunity. However, many reports of adverse reactions caused by TGt have limited its application. Read More

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Pediatric idiopathic steroid-sensitive nephrotic syndrome: diagnosis and therapy -short version of the updated German best practice guideline (S2e) - AWMF register no. 166-001, 6/2020.

Pediatr Nephrol 2021 Jun 6. Epub 2021 Jun 6.

Faculty of Medicine and University Hospital Cologne, Pediatric Nephrology, Children's and Adolescents' Hospital, University of Cologne, Cologne, Germany.

Idiopathic nephrotic syndrome is the most frequent glomerular disease in children in most parts of the world. Children with steroid-sensitive nephrotic syndrome (SSNS) generally have a good prognosis regarding the maintenance of normal kidney function even in the case of frequent relapses. The course of SSNS is often complicated by a high rate of relapses and the associated side effects of repeated glucocorticoid (steroid) therapy. Read More

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Characteristics of ischemic stroke and intracranial hemorrhage in patients with nephrotic syndrome.

BMC Nephrol 2021 Jun 5;22(1):213. Epub 2021 Jun 5.

Department of Neurology, Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Linkou Branch, 5, Fu Hsing Street, 333, Taoyuan, Taiwan.

Background: The incidence of cerebral stroke, including ischemic infarction and intracranial hemorrhage (ICH), increases in patients with nephrotic syndrome (NS). However, the clinical characteristics of patients with NS and stroke remain elusive. We aimed to investigate the clinical presentation and prognosis among patients with NS and ischemic stroke (IS) or ICH. Read More

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Effect assessment of evidence-based nursing in combination with clinical nursing pathway on nephrotic syndrome care in children: A protocol for systematic review and meta-analysis.

Xia Yu Cai-Yan Han

Medicine (Baltimore) 2021 Jun;100(22):e25990

Department of Neurology, Hanchuan People's Hospital, Hanchuan, Hubei Province, China.

Background: Childhood nephrotic syndrome is widespread in pediatric nephrology. In most cases, it needs hospitalization for patient management. An increasing number of studies report that proper nursing care could promote the rate of treatment and improve post-treatment prognosis. Read More

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Successful long-term management of recurrent focal segmental glomerulosclerosis after kidney transplantation with costimulation blockade.

Clin Kidney J 2021 Jun 23;14(6):1691-1693. Epub 2020 Dec 23.

Department of Diabetology, Endocrinology, Nephrology, Section of Nephrology and Hypertension, University of Tübingen, Tübingen, Germany.

Recurrence of primary focal segmental glomerulosclerosis (FSGS) occurs in up to 50% of patients after kidney transplantation and is associated with poor allograft outcome. Novel therapeutic concepts directly target podocyte function via B7-1 with inconsistent response. We present the case of a 19-year-old patient with recurrent primary FSGS early after living donor kidney transplantation. Read More

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Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Department of Nephrology, Tokyo Metropolitan Geriatric Hospital, Itabashi-ku, Japan.

The diagnosis of elderly-onset IgA vasculitis (IgAV) and its prognosis can be difficult to ascertain because of its rarity and the frequent presence of comorbidities. Furthermore, the treatment of elderly-onset IgAV remains controversial. We report a case of IgAV in an 87-year-old patient. Read More

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Acute Kidney Injury in Hospitalized Children with COVID19.

J Trop Pediatr 2021 05;67(2)

Department of Paediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi 110001, India.

Background: Acute kidney injury (AKI) has been recognized as a significant risk factor for mortality among adults with severe acute respiratory syndrome coronavirus infection.

Aim: The aim of this study is to assess the prevalence and risk factors for AKI and mortality in children with coronavirus disease 2019 (COVID19) from a resource-limited setting.

Methods: Cross-sectional analysis of laboratory confirmed COVID19 children admitted from 1 March to 30 November 2020 in a tertiary care hospital in New Delhi, India was done. Read More

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Treatment Outcomes of Pediatric Nephrotic Syndrome Patients Treated in Ayder Comprehensive Specialized and Mekelle General Hospitals, Ethiopia.

Int J Nephrol Renovasc Dis 2021 24;14:149-156. Epub 2021 May 24.

Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Nephrotic syndrome is a common glomerular disease in children with a relapsing course that leads to complications and steroid-related toxicities. In Ethiopia, data on the outcomes of steroid therapy in pediatric nephrotic syndrome patients are limited.

Objective: The aim of the study was to assess the treatment outcomes of pediatric nephrotic syndrome patients in Ayder Specialized Comprehensive and Mekelle General Hospitals. Read More

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Efficacy and safety of Huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review.

World J Pediatr 2021 Jun 1. Epub 2021 Jun 1.

Department of Nephrology, National Clinical Research Center For Child Health, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Background: Huaiqihuang (HQH) granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome (PNS) for many years. However, the effectiveness and safety of HQH have not been systematically discussed. This review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with PNS. Read More

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Role of Arachidonic Acid and Its Metabolites in the Biological and Clinical Manifestations of Idiopathic Nephrotic Syndrome.

Int J Mol Sci 2021 May 21;22(11). Epub 2021 May 21.

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Pediatric Nephrology, Dialysis and Transplant Unit, Via della Commenda 9, 20122 Milan, Italy.

Studies concerning the role of arachidonic acid (AA) and its metabolites in kidney disease are scarce, and this applies in particular to idiopathic nephrotic syndrome (INS). INS is one of the most frequent glomerular diseases in childhood; it is characterized by T-lymphocyte dysfunction, alterations of pro- and anti-coagulant factor levels, and increased platelet count and aggregation, leading to thrombophilia. AA and its metabolites are involved in several biological processes. Read More

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Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS).

Stem Cell Res 2021 May 25;54:102406. Epub 2021 May 25.

Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Stem Cell Core Facility, Berlin, Germany; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Berlin, Germany. Electronic address:

Focal segmental glomerulosclerosis (FSGS) is a major cause of familial nephrotic syndrome. We generated 20 induced pluripotent stem cell lines from patients diagnosed with FSGS. The iPSC lines include 8 female and 12 male lines and cover a donor age range from 31 to 78. Read More

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Distribution of serum adiponectin isoforms in pediatric patients with steroid-sensitive nephrotic syndrome.

Clin Exp Nephrol 2021 Jun 1. Epub 2021 Jun 1.

Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.

Background: Serum adiponectin circulates in three multimeric isoforms: high-molecular-weight (HMW), middle-molecular-weight (MMW), and low-molecular-weight (LMW) isoforms. Potential change in the circulating adiponectin levels in patients with nephrotic syndrome (NS) remain unknown. This study aimed to assess the levels of total adiponectin and the distribution of its isoforms in pediatric patients with NS. Read More

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[The 489th case: acute kidney injury, gross hematuria, nephrotic syndrome].

Zhonghua Nei Ke Za Zhi 2021 Jun;60(6):589-592

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Onset with fever and back pain, an 81-year-old man had sudden oliguria and progressively elevated serum creatine from normal range to 660 μmol/L within 1 week after receiving contrast agents, various antibiotics, and several nonsteroidal anti-inflammation drugs. Urine output recovered after supportive treatment. However, his serum creatinine level rose again soon after a temporary decline accompanied by gross hematuria with almost normal morphology, nephrotic proteinuria, and hypoalbuminemia. Read More

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