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Front Pharmacol 2022 2;13:817020. Epub 2022 May 2.

Department of Medical and Surgical Therapeutics, Medical School, Institute of Molecular Pathology Biomarkers, University of Extremadura, Badajoz, Spain.

Nephrosclerosis patients have a high cardiovascular (CV) risk that is very often of more concern than the renal disease itself. We aimed to determine whether variants in phospholipase-related genes, associated with atherosclerosis and CV outcomes in the general population, could constitute biomarkers of nephrosclerosis and/or its associated CV risk. We screened 1,209 nephrosclerosis patients and controls for 86 tag-SNPs that were identified in the , and gene loci. Read More

Rev Med Virol 2022 May 6:e2357. Epub 2022 May 6.

Department of Tropical Medicine, Federal University of Pernambuco, Recife, Brazil.

Several atypical forms of chikungunya fever (CHIK) have been described, including neurological, cardiac and renal involvement. These forms may be related to high morbidity and mortality rates. This scoping review based on the PubMed, Scopus, and WOS databases aims to identify and summarise all the available evidence regarding the clinical and histopathological presentations and risk factors associated with kidney injury related to CHIK, as well as the clinical impact. Read More

Kidney Int Rep 2022 Apr 19;7(4):831-840. Epub 2022 Jan 19.

Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain.

Introduction: Anticoagulant-related nephropathy (ARN) is a relatively novel recognized entity characterized by hematuria-associated acute kidney injury (AKI) in the context of overanticoagulation. Preexisting or underlying kidney disease seems to be a predisposing factor; however, few studies have described histologic findings in patients with ARN. We aimed to evaluate underlying kidney pathology in patients on oral anticoagulation who presented an episode of AKI with hematuria in whom a kidney biopsy was performed. Read More

Front Med (Lausanne) 2022 31;9:836155. Epub 2022 Mar 31.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, National Health and Family Planning Commission of the People's Republic of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment, Ministry of Education, Beijing, China.

Background: Complement dysregulation has been implicated in the pathogenesis of malignant nephrosclerosis with typical pathological manifestation as thrombotic microangiopathy (TMA) in recent studies. The aim of the present study was to evaluate the potential role of complement activation in arterionephrosclerosis, the major pathological change in benign hypertensive nephrosclerosis.

Methods: Patients with biopsy-proven arterionephrosclerosis from 2010 to 2018 in our center were retrospectively enrolled in the present study. Read More

Nephrol Dial Transplant 2022 Mar 22. Epub 2022 Mar 22.

Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan.

Background: The KDIGO guidelines advocate the cause-GFR-albuminuria (CGA) classification for predicting outcomes. However, there is a dearth of data supporting the use of the cause of chronic kidney disease (CKD). This study aimed to address how to incorporate a prior biopsy-proven diagnosis in outcome prediction. Read More

BMC Nephrol 2022 03 15;23(1):104. Epub 2022 Mar 15.

Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Background: Patients with end-stage kidney disease (ESKD) face higher risks of life-threatening events including cardiovascular disease. Various risk factors are identified as agents influencing the life prognosis of ESKD patients. Herein, we evaluated the risk factors related to the outcomes of Japanese patients with dialysis induction. Read More

Clin Chim Acta 2022 May 9;530:81-86. Epub 2022 Mar 9.

Department of Anatomical & Cellular Pathology, Prince of Wales Hospital, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Background: Urinary micro-RNA (miRNA) level may serve as non-invasive disease markers for immunoglobulin A nephropathy (IgAN), but urinary miRNA targets identified in previous studies may represent kidney scarring rather than being specific for IgAN. We aim to identify urinary miRNA targets for the diagnosis of IgAN by including hypertensive nephrosclerosis (HTN) as a control group. Methods In the development cohort, we performed complete miRNA profiling of urinary sediment in 33 patients with IgAN, 9 with HTN, and 9 healthy controls (CTL). Read More

Kidney Int Rep 2022 Mar 11;7(3):580-590. Epub 2022 Jan 11.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Introduction: The clinicopathologic characteristics of nephropathy associated with mitochondrial disease (MD) remain unknown. We retrospectively analyzed a cohort of patients with proteinuria, decreased glomerular filtration rate, or Fanconi syndrome who had a genetic mutation confirmed as the cause of MD, defined as mitochondrial nephropathy.

Methods: This nationwide survey included 757 nephrology sections throughout Japan, and consequently, data on 81 cases of mitochondrial nephropathy were collected. Read More

Med Phys 2022 Apr 11;49(4):2295-2308. Epub 2022 Mar 11.

Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.

Purpose: As a typical chronic kidney disease (CKD), hypertensive nephrosclerosis (HN) is a common syndrome of hypertension, characterized by chronic kidney microvascular damage. Early diagnosis of microvascular damage using conventional ultrasound imaging encounters challenges in sensitivity and specificity owing to the inherent diffraction limit. Ultrasound localization microscopy (ULM) has been developed to obtain microvasculature and microvascular hemodynamics within the kidney, and would be a promising tool for the early diagnosis of CKD. Read More

PLoS One 2022 25;17(2):e0264568. Epub 2022 Feb 25.

Department of Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Diabetic kidney disease (DKD) is heterogeneous in terms of proteinuria. Patients with DKD who present with low-grade proteinuria are more likely to have nephrosclerosis rather than traditional diabetic nephropathy. The amount of proteinuria might reflect the underlying pathology of renal failure and influence the prognosis after dialysis initiation. Read More

PLoS One 2022 17;17(2):e0264136. Epub 2022 Feb 17.

Ottawa Hospital Research Institute & Kidney Research Centre, University of Ottawa, Ottawa, ON, Canada.

Current research on hypertension utilizes more than fifty animal models that rely mainly on stable increases in systolic blood pressure. In experimental hypertension, grading or scoring of glomerulopathy in the majority of studies is based on a wide range of opinion-based histological changes that do not necessarily comply with lesional descriptors for glomerular injury that are well-established in clinical pathology. Here, we provide a critical appraisal of experimental hypertensive glomerulopathy with the same approach used to assess hypertensive glomerulopathy in humans. Read More

Clin Exp Nephrol 2022 Jun 3;26(6):530-539. Epub 2022 Feb 3.

Department of Analytic Human Pathology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo, 113-0022, Japan.

Background: The aim of this autopsy study was to clarify the differences of renal histopathology between non-chronic kidney disease (CKD) and CKD caused by hypertensive-nephrosclerosis in the elderly and during the aging process.

Methods: We examined autopsy specimens from 105 elderly patients (53 male subjects; mean age, 86.2 years) including 44 patients with CKD as a result of nephrosclerosis. Read More

Am J Nephrol 2022 1;53(1):69-77. Epub 2022 Feb 1.

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Information regarding the influence of serum uric acid (SUA) levels on pathological changes in the kidney is limited. In this study, we examined the association between SUA levels and pathological findings of nephrosclerosis in population-based autopsy samples.

Methods: A total of 923 deceased individuals in a Japanese community underwent autopsy examinations between 1974 and 1994. Read More

Transplant Proc 2022 Mar 11;54(2):225-229. Epub 2022 Jan 11.

Department of Hepato-Biliary Pancreatic/Transplantation Surgery, Asahikawa Medical University, Hokkaido, Japan.

Background: Machine perfusion of marginal kidney grafts obtained from donors after cardiac death (DCD) has become a standard therapy worldwide. However, the use of grafts from DCD due to long-term low blood pressure is associated with a high incidence of primary graft nonfunction. Furthermore, the importance of oxygenation in machine perfusion remains unclear. Read More

Case Rep Oncol 2021 Sep-Dec;14(3):1574-1579. Epub 2021 Nov 5.

Division of Haematology/Oncology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Haematopoietic insufficiency is the treatment target of lower-risk myelodysplastic syndrome (MDS). Although erythropoiesis-stimulating agents (ESAs) are generally effective for treating anaemia, resistance can develop. Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) improves renal anaemia by promoting endogenous erythropoietin production and normalizing iron metabolism. Read More

Medicine (Baltimore) 2021 Dec;100(51):e28318

Department of Nephrology, Gaozhou City People's Hospital, Gaozhou, Guangdong, China.

Abstract: Equations to estimate glomerular filtration rate (eGFR) are useful for monitoring tje renal status of benign hypertensive nephrosclerosis (BHN). This study aimed to compare the applicability of 6 equations (Cockcroft-Gault [CG] adjusted for body surface area, original modification of diet in renal disease [MDRD], American abbreviated MDRD, Chinese modified MDRD, Chinese abbreviated MDRD, and Chronic Kidney Disease Epidemiology [CKD-EPI]) to estimate GFR in a Chinese BHN population. A total of 179 patients diagnosed with BHN were enrolled. Read More

Vet Pathol 2022 03 6;59(2):358-370. Epub 2021 Dec 6.

University of Wisconsin, Madison, WI, USA.

In a retrospective study of a western pygmy marmoset () colony, postmortem examination of 1/8 juvenile and 29/47 adult animals identified vascular, cardiac, and renal lesions consistent with systemic hypertension. This included frequent renal arteriolar hypertrophy, hyaline and proliferative arteriolosclerosis, fibrinoid necrosis of arterioles, glomerulosclerosis, and nephrosclerosis. Affected animals ranged from 0. Read More

Clin Exp Nephrol 2022 Apr 30;26(4):341-349. Epub 2021 Nov 30.

Nephrology Center and Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.

Background And Purpose: We examined whether advances in treatment strategies from older disease-modifying antirheumatic drugs (DMARDs) to new biologic agents and methotrexate improved renal complications and outcome in patients with rheumatoid arthritis (RA).

Methods: We reviewed records of 156 patients with RA who underwent kidney biopsy at our institute between January 1990 and December 2019. All patients were assigned to one of three periods: period 1, 1990-1999 (n = 48); period 2, 2000-2009(n = 57); period 3, 2010-2019 (n = 51). Read More

Cells 2021 11 12;10(11). Epub 2021 Nov 12.

IMBECU-CONICET, Instituto de Medicina y Biología Experimental de Cuyo-Consejo Nacional de Investigaciones Científicas y Técnicas, Mendoza 5500, Argentina.

Hypertensive nephrosclerosis is the second most common cause of end-stage renal disease after diabetes. For years, hypertensive kidney disease has been focused on the afferent arterioles and glomeruli damage and the involvement of the renin angiotensin system (RAS). Nonetheless, in recent years, novel evidence has demonstrated that persistent high blood pressure injures tubular cells, leading to epithelial-mesenchymal transition (EMT) and tubulointerstitial fibrosis. Read More

Clin Exp Nephrol 2022 Apr 23;26(4):325-332. Epub 2021 Nov 23.

Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa, Japan.

Background: Patients with nephrosclerosis display heterogenous clinical phenotypes, often leading to a clinical diagnosis discordant with pathological nephrosclerosis diagnosis. However, little is known about clinical factors associated with clinicopathological discordance of biopsy-proven nephrosclerosis.

Methods: In a cross-sectional study of 891 patients with biopsy-proven nephrosclerosis registered in the Japan Renal Biopsy Registry (J-RBR) between July 2007 and June 2016, we examined clinical characteristics associated with a pre-biopsy clinical diagnosis discordant with pathological nephrosclerosis diagnosis using multivariable logistic regression with adjustment for relevant clinical characteristics. Read More

Clin Sci (Lond) 2021 12;135(23):2643-2658

Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Acute kidney injury (AKI)-related fibrosis is emerging as a major driver of chronic kidney disease (CKD) development. Aberrant kidney recovery after AKI is multifactorial and still poorly understood. The accumulation of indoxyl sulfate (IS), a protein-bound uremic toxin, has been identified as a detrimental factor of renal fibrosis. Read More

Int J Mol Sci 2021 Oct 28;22(21). Epub 2021 Oct 28.

INSERM UMR_S1155, Tenon Hospital, 75020 Paris, France.

Chronic kidney disease (CKD), secondary to renal fibrogenesis, is a public health burden. The activation of interstitial myofibroblasts and excessive production of extracellular matrix (ECM) proteins are major events leading to end-stage kidney disease. Recently, interleukin-15 (IL-15) has been implicated in fibrosis protection in several organs, with little evidence in the kidney. Read More

J Am Vet Med Assoc 2021 11 10;259(12):1422-1427. Epub 2021 Nov 10.

From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610.

Objective: To characterize the signalment, clinical signs, clinical pathological and histologic findings, and outcome in 8 related Bracchi Italiani with proteinuric kidney disease.

Animals: 8 client-owned Bracchi Italiani.

Procedures: Health records submitted to the Bracco Italiano Health Foundation and the Bracco Italiano Club of America between 2012 and 2019 were reviewed for dogs with evidence of nephropathy for which histologic diagnoses were obtained. Read More

Mol Med Rep 2022 01 5;25(1). Epub 2021 Nov 5.

Department of General Practice, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570100, P.R. China.

Chronic hypertension can lead to kidney damage, known as hypertensive nephropathy or hypertensive nephrosclerosis. Further understanding of the molecular mechanisms via which hypertensive nephropathy develops is essential for effective diagnosis and treatment. The present study investigated the mechanisms by which endothelial progenitor cells (EPCs) repair primary rat kidney cells (PRKs). Read More

Chirurg 2021 Oct 4. Epub 2021 Oct 4.

Contilia Herz- und Gefäßzentrum, Klinik für Gefäßchirurgie und Phlebologie, Elisabeth-Krankenhaus Essen, Klara-Kopp-Weg 1, 45138, Essen, Deutschland.

In Germany approximately 70,000 patients with a renal insufficiency are treated by hemodialysis. The most frequent reasons for the need for dialysis are currently diabetic nephropathy and nephrosclerosis. Due to the increasing average age and the resulting multimorbidity of dialysis patients, the difficulties of medical care have also increased. Read More

Nihon Ronen Igakkai Zasshi 2021 ;58(3):482-488

Department of Internal Medicine, Mitoyo General Hospital.

A 71-year-old man with a history of hypertension and nephrosclerosis visited a primary care doctor for a regular visit. After a few days of vomiting and diarrhea, gastroenteritis was suspected and he was prescribed medication for these symptoms by his previous doctor. The next morning, he visited our hospital complaining of malaise and abdominal distention. Read More

J Pers Med 2021 Aug 6;11(8). Epub 2021 Aug 6.

Department of Medical and Surgical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, 06006 Badajoz, Spain.

Prostaglandin E2 (PGE2) is a major actor mediating renal injury. We aimed to determine genetic variability in the genes coding for its receptors () and study associations with nephrosclerosis risk and clinical outcomes. We identified 96 tag-SNPs capturing global variability in and screened 1209 nephrosclerosis patients and controls. Read More

PLoS One 2021 20;16(8):e0256522. Epub 2021 Aug 20.

Finnish Registry for Kidney Diseases, Helsinki, Finland.

Background: Comorbidities are associated with increased mortality among patients receiving long-term kidney replacement therapy (KRT). However, it is not known whether primary kidney disease modifies the effect of comorbidities on KRT patients' survival.

Methods: An incident cohort of all patients (n = 8696) entering chronic KRT in Finland in 2000-2017 was followed until death or end of 2017. Read More

Clin Toxicol (Phila) 2022 Mar 17;60(3):304-310. Epub 2021 Aug 17.

National Drug & Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Introduction: Gabapentinoids are centrally active GABA agonists whose use has increased substantially in the past decade. The current study aimed to provide a comprehensive clinical profile of a national case series of fatal poisonings related to gabapentinoids.

Methods: Retrospective study of all deaths due to drug toxicity in Australia in which gabapentinoids were a contributory mechanism, retrieved from the National Coronial Information System (2000-2020). Read More

Contrib Nephrol 2021 3;199:266-273. Epub 2021 Aug 3.

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Clinical Background: Older age has been associated with higher prevalence and progression of chronic kidney disease (CKD). The presence of CKD leads to an increased risk of end-stage renal disease, cardiovascular diseases, and death. Epidemiology: Progressive aging of the population is accompanied by an increase in the prevalence of CKD worldwide. Read More