2,429 results match your criteria Nephrosclerosis


A Case of Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.

A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Read More

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November 2018
5 Reads

Volume Ratio of Glomerular Tufts to Bowman Capsules and Renal Outcomes in Nephrosclerosis.

Am J Hypertens 2019 Jan;32(1):45-53

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Background: The concomitant appearance of glomerular collapse and enlargement is characteristic of the histological findings in nephrosclerosis. However, no previous study quantitatively examined the clinicopathological significance of this feature in patients with biopsy-proven nephrosclerosis.

Methods: Renal biopsy specimens and follow-up data from nephrosclerosis patients with estimated glomerular filtration rates >30 ml/min/1. Read More

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January 2019
7 Reads

Klotho Ameliorates Medullary Fibrosis and Pressure Natriuresis in Hypertensive Rat Kidneys.

Hypertension 2018 Nov;72(5):1151-1159

Department of Nephrology, Saitama Medical University, Iruma, Japan (T.I., T.M., H.S.).

Renal expression of klotho is reduced in hypertension. Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensive rats (sp-SHR). The interactions between klotho protein and renal renin-Ang (angiotensin) system were examined with immunoprecipitation and cell culture methods. Read More

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November 2018
1 Read

Autopsy Patients With Obesity or Metabolic Syndrome as Basic Cause of Death: Are There Pathological Differences Between These Groups?

Clin Med Insights Pathol 2018 30;11:1179555718791575. Epub 2018 Jul 30.

Department of Pathology, School of Medicine of Botucatu, São Paulo State University, FMB-UNESP, Botucatu, Brazil.

Background: The objectives of this study were the evaluation of pathological characteristics of patients with obesity or metabolic syndrome (MS) as basic cause of death, associating the autopsy findings with some clinical aspects and the abdominal adipose panicle thickness.

Methods: A total of 88 autopsy cases were studied, divided into 2 groups based on the main cause of death: group 1 (n = 15) obesity and group 2 (n = 73) MS. Clinical summaries of autopsy requests, macroscopic findings, and histologic sections were reviewed. Read More

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July 2018
7 Reads

Estimated glomerular filtration rate decline and risk of end-stage renal disease in type 2 diabetes.

PLoS One 2018 2;13(8):e0201535. Epub 2018 Aug 2.

Department of Nephrology, Kanazawa University Hospital, Kanazawa, Japan / Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: According to studies by the National Kidney Foundation and Food and Drug Administration, 30% and 40% declines in estimated glomerular filtration rate (eGFR) could be used as surrogate endpoints of end-stage renal disease (ESRD). However, the benefits of using these endpoints in diabetic patients remain unclear.

Methods: This cohort study comprised Japanese patients with type 2 diabetes; those with repeated serum creatinine measurements during a baseline period of 2 years (n = 1868) or 3 years (n = 2001) were enrolled. Read More

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August 2018
1 Read

APOL1 risk variants and kidney disease: what we know so far.

J Bras Nefrol 2018 Jul 26. Epub 2018 Jul 26.

Beth Israel Deaconess Medical Center, Boston, MA, United States.

There are striking differences in chronic kidney disease between Caucasians and African descendants. It was widely accepted that this occurred due to socioeconomic factors, but recent studies show that apolipoprotein L-1 (APOL1) gene variants are strongly associated with focal segmental glomerulosclerosis, HIV-associated nephropathy, hypertensive nephrosclerosis, and lupus nephritis in the African American population. These variants made their way to South America trough intercontinental slave traffic and conferred an evolutionary advantage to the carries by protecting against forms of trypanosomiasis, but at the expense of an increased risk of kidney disease. Read More

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July 2018
8 Reads

MicroRNA-214-3p in the Kidney Contributes to the Development of Hypertension.

J Am Soc Nephrol 2018 Oct 26;29(10):2518-2528. Epub 2018 Jul 26.

Center of Systems Molecular Medicine, Department of Physiology,

Background: In spite of extensive study, the mechanisms for salt sensitivity of BP in humans and rodent models remain poorly understood. Several microRNAs (miRNAs) have been associated with hypertension, but few have been shown to contribute to its development.

Methods: We examined miRNA expression profiles in human kidney biopsy samples and rat models using small RNA deep sequencing. Read More

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October 2018
4 Reads

Environmental impact on the onset of hypertension-induced end-stage renal disease.

Int J Environ Health Res 2018 Oct 10;28(5):511-521. Epub 2018 Jul 10.

b Department of Nephrology , Krishna Institute of Medical Sciences , Secunderabad , India.

This study intends to assess the impact of environmental factors on the onset of hypertension-induced end-stage renal disease (ESRD) and to compare the level of oxidative stress with nonhypertensive diabetic ESRD. ESRD patients were evaluated along with healthy controls through questionnaire for demographic, nutritional and lifestyle variables. Oxidants were measured along with antioxidants. Read More

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October 2018
2 Reads

The Relationship between the Intrarenal Dopamine System and Intrarenal Renin-angiotensin System Depending on the Renal Function.

Intern Med 2018 Nov 6;57(22):3241-3247. Epub 2018 Jul 6.

Internal Medicine 1, Hamamatsu University School of Medicine, Japan.

Objective The mechanisms underlying the intrarenal renin-angiotensin system (RAS) activation depend on the conditions of kidney diseases. In angiotensin II (AngII) infusion models, the circulating AngII is filtered into the renal tubular lumens, activating intrarenal RAS. However, in the chronic kidney disease (CKD) models, plasma angiotensinogen (AGT) is filtered into the tubular lumens because of glomerular injury, activating intrarenal RAS. Read More

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November 2018
6 Reads

Key role of renal biopsy in management of progressive chronic kidney disease in liver graft recipients.

J Nephrol 2018 Jun 26. Epub 2018 Jun 26.

Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.

Aims: Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). The etiology of CKD is broad and may only be assessed accurately by renal histology. The current study aimed to analyze the safety of renal biopsy in daily clinical practice as well as its usefulness regarding management of CKD after LT. Read More

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June 2018
5 Reads

Impact of high mortality in incident dialysis patients due to hypertensive nephrosclerosis: a multicenter prospective cohort study in Aichi, Japan.

Clin Exp Nephrol 2018 Jun 7. Epub 2018 Jun 7.

Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Introduction: An increasing number of patients worldwide require dialysis as a result of hypertensive nephrosclerosis (HTN). However, in Japan, mortality in patients with end-stage renal disease (ESRD) has not been well by primary kidney disease including HTN and diabetic nephropathy (DN). Hence, we examined the differences in mortality among the primary kidney diseases of incident dialysis patients. Read More

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June 2018
2 Reads

Microscopic polyangiitis necrotizing glomerulonephritis associated with pregnancy: case with a 20-year clinical course and review of the literature.

CEN Case Rep 2018 11 5;7(2):274-281. Epub 2018 Jun 5.

Nephrology Center, Toranomon Hospital, 2-2-2, Toranomon, Minato, Tokyo, 105-8470, Japan.

A 29-year-old woman with past medical history of hypertension was referred to our hospital for the evaluation of kidney dysfunction (serum creatinine 1.0 mg/dL), proteinuria (0.54 g/gCre), and microscopic hematuria. Read More

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November 2018
6 Reads

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume.

J Am Soc Nephrol 2018 Jul 22;29(7):1960-1969. Epub 2018 May 22.

Divisions of Nephrology and Hypertension,

Glomerular volume increases when demand exceeds nephron supply, which may lead to glomerulosclerosis. It is unclear if determinants of glomerular volume are consistent between populations that differ by severity of comorbidities. We studied kidney biopsy specimens from living kidney donors (=2453) and patients who underwent radical nephrectomy for a renal tumor (=780). Read More

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July 2018
3 Reads

Clinicopathological predictors for progression of chronic kidney disease in nephrosclerosis: a biopsy-based cohort study.

Nephrol Dial Transplant 2018 May 19. Epub 2018 May 19.

Department of Nephrology and Laboratory Medicine, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Background: Biopsy-based studies on nephrosclerosis are lacking and the clinicopathological predictors for progression of chronic kidney disease (CKD) are not well established.

Methods: We retrospectively assessed 401 patients with biopsy-proven nephrosclerosis in Japan. Progression of CKD was defined as new-onset end-stage renal disease, decrease of estimated glomerular filtration rate (eGFR) by  ≥50% or doubling of serum creatinine, and the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined for various clinical and histological characteristics in competing risks analysis. Read More

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May 2018
3 Reads

Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases.

Clin Chim Acta 2018 Sep 17;484:36-39. Epub 2018 May 17.

Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, SAR, China. Electronic address:

Background: Mitochondrial dysfunction plays an important role in the pathogenesis and progression of chronic kidney disease (CKD). We study the relation between urinary mitochondrial DNA (mtDNA) levels and renal dysfunction in non-diabetic CKD.

Methods: We recruited 32 CKD patients (20 had hypertensive nephrosclerosis, 12 had IgA nephropathy). Read More

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September 2018
2 Reads
2.824 Impact Factor

Clinico-pathological features of kidney disease in diabetic cases.

Clin Exp Nephrol 2018 Oct 21;22(5):1046-1051. Epub 2018 Mar 21.

Department of Nephrology and Laboratory Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Diabetic kidney disease is the major cause of end-stage kidney disease in developed countries. However, the onset of kidney disorder and the progression pattern of kidney dysfunction and proteinuria greatly vary cases by cases. Therefore, risk classification with clinical data and pathological findings is important. Read More

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October 2018
4 Reads

SUSPECTED HYPERVITAMINOSIS D IN RED-RUMPED AGOUTI ( DASYPROCTA LEPORINA) RECEIVING A COMMERCIAL RODENT DIET.

J Zoo Wildl Med 2018 Mar;49(1):196-200

An 8 yr, intact male red-rumped agouti ( Dasyprocta leporina) was evaluated for weight loss. Examination revealed poor body condition, hypercalcemia, elevated serum 25-hydroxyvitamin D, metastatic calcification of soft tissues, and hyperechoic kidneys. The diet, formulated for laboratory rodents, contained elevated levels of vitamin D. Read More

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March 2018
3 Reads

Management of a patient with vesicocutaneous fistula presenting 13 years after radiotherapy performed for cervical cancer.

Turk J Urol 2018 Mar 11;44(2):185-188. Epub 2017 Dec 11.

Department of Urology, Kyungpook National University School of Medicine, Daegu, Korea.

A vesicocutaneous fistula (VCF) is a tract that is formed abnormally between the bladder and the external surface of the body. VCF results in a great deal of inconvenience, discomfort, and physical disability for the affected patient. This condition can be caused by extensive trauma with pelvic bone fracture, radical pelvic surgery, irradiation of pelvic malignancies, hip arthroplasty, a large bladder calculus, and various other pathologies. Read More

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March 2018
7 Reads

[The clinical and morphological characteristics of C1q glomerulopathy].

Arkh Patol 2018 ;80(1):46-51

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

C1q glomerulopathy is a rare variety of chronic glomerulonephritis manifested as C1q deposition revealed by immunofluorescence microscopy. The pathogenesis and etiology of the disease have not been studied. The paper deals with the results of clinical, morphological, immunofluorescence, and electron microscopic examinations in 13 patients with C1q glomerulopathy. Read More

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January 2018
2 Reads

Renal shear wave elastography for the assessment of nephron hypertrophy: a cross-sectional study in chronic kidney disease.

J Med Ultrason (2001) 2018 Oct 6;45(4):571-576. Epub 2018 Feb 6.

Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, Tottori University, 36-1 Nishimachi, Yonago, Tottori, 683-8504, Japan.

Purpose: To investigate the association of renal elasticity to microscopic findings of nephron hypertrophy and nephrosclerosis.

Methods: Patients who underwent renal biopsy were enrolled. Renal elasticity was measured by acoustic radiation force impulse, and nephron size (glomerular volume, non-sclerotic glomerular density, and mean profile tubular area) and nephrosclerosis (globally sclerotic glomeruli and interstitial fibrosis) were estimated. Read More

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October 2018
6 Reads

Tick-Tock Chimes the Kidney Clock - from Biology of Renal Ageing to Clinical Applications.

Kidney Blood Press Res 2018 24;43(1):55-67. Epub 2018 Jan 24.

Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, United Kingdom.

Ageing of the kidney is a multi-dimensional process that occurs simultaneously at the molecular, cellular, histological, anatomical and physiological level. Nephron number and renal cortical volume decline, renal tubules become atrophic and glomeruli become sclerotic with age. These structural changes are accompanied by a decline in glomerular filtration rate, decreased sodium reabsorption and potassium excretion, reduced urinary concentrating capacity and alterations in the endocrine activity of the kidney. Read More

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September 2018
6 Reads

Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study.

PLoS One 2018 17;13(1):e0190493. Epub 2018 Jan 17.

Department of Nephrology, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.

Background: Although lower estimated glomerular filtration rate (eGFR) and higher proteinuria are high risks for mortality and kidney outcomes, the prognosis of chronic kidney disease (CKD) in patients with normal-range proteinuria remains unclear.

Methods: In this prospective cohort study, 1138 newly visiting stage G2-G5 CKD patients were stratified into normal-range and abnormal-range proteinuria groups. Study endpoints were CKD progression (>50% eGFR loss or initiation of dialysis), cardiovascular events, and all-cause death. Read More

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February 2018
5 Reads

Risk Variants Independently Associated With Early Cardiovascular Disease Death.

Kidney Int Rep 2018 Jan 24;3(1):89-98. Epub 2017 Aug 24.

Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA.

Introduction: The relationship of renal risk variants to cardiovascular disease (CVD) is controversial and was the subject of this investigation.

Methods: Age, cause of death, and nephrosclerosis (the latter defined by glomerulosclerosis) were analyzed in the autopsies of 162 African Americans and 136 whites genotyped for risk alleles.

Results: Sudden deaths represented >75% of CVD autopsies for both races and all-risk genotypes. Read More

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January 2018
2 Reads

Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses.

Mol Med Rep 2018 Mar 9;17(3):4440-4448. Epub 2018 Jan 9.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China.

Hypertensive nephrosclerosis (HNS) is a major risk factor for end-stage renal disease. However, the underlying pathogenesis of HNS remains to be fully determined. The gene expression profile of GSE20602, which consists of 14 glomeruli samples from patients with HNS and 4 normal glomeruli control samples, was obtained from the Gene Expression Omnibus database. Read More

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March 2018
7 Reads

Pathologic analysis of non-neoplastic parenchyma in renal cell carcinoma: a comprehensive observation in radical nephrectomy specimens.

BMC Cancer 2017 12 28;17(1):900. Epub 2017 Dec 28.

Department of Urology Renji Hospital affiliated to Shanghai Jiaotong, University School of Medicine, No.1630, Dongfang Road, Shanghai, 200127, China.

Background: This study provides a comprehensive examination of the histological features of non-neoplastic parenchyma in renal cell carcinoma (RCC). We prospectively collected radical nephrectomy (RN) specimens, to analyze the histological changes within peritumoral and distant parenchyma.

Methods: Data of patients who underwent RN and had no known history of diabetes, hypertension, hyperlipidemia, or chronic kidney disease etc. Read More

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December 2017
10 Reads

Clinicopathological study of nondiabetic renal disease in type 2 diabetic patients: A single center experience from India.

Saudi J Kidney Dis Transpl 2017 Nov-Dec;28(6):1330-1337

Department of Nephrology and Transplantation Medicine, G. R. Doshi and K. M. Mehta Institute of Kidney Diseases and Research Center and Dr. H. L. Trivedi Institute of Transplantation Sciences, Civil Hospital Campus, Asarwa, Ahmedabad, India.

Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM), leading to chronic kidney disease/end-stage renal disease. Wide spectrum of nondiabetic renal diseases (NDRD) is reported in type-2 diabetes (type-2 DM). We carried out this single-center study to find clinical, laboratory, and histological features of NDRD in type-2 DM patients and to assess the prevalence of NDRD in India. Read More

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December 2017
17 Reads

A Blood Pressure You Can Believe In.

Nephrol Nurs J 2017 Jan-Feb;44(1):57-71

Chief of the Preventive Medicine Section, the Veterans' Affairs Medical Center, Memphis, TN.

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August 2018
7 Reads

Bowel Migration of Dormant Chronic Ambulatory Peritoneal Dialysis Catheter: A Vexed Problem Not Avoided by Flushing.

Indian J Nephrol 2017 Nov-Dec;27(6):484-486

Department of Urology and Nephrology, Aster MIMS Hospital, Malappuram, Kerala, India.

Delayed bowel erosion by peritoneal dialysis catheter is rare with fewer than thirty cases having been reported in the literature. This complication is usually encountered when the catheter is kept dormant. Two cases have also been reported with catheters in active use. Read More

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December 2017
8 Reads

First case report of using Ofatumumab in kidney transplantation AB0 incompatible.

G Ital Nefrol 2017 Dec 5;34(Nov-Dec). Epub 2017 Dec 5.

UOC Nefrologia, Dialisi e Trapianto, Azienda Ospedaliera Universitaria Senese, Siena.

Modern methods for desensitization protocol rely heavily on combined apheresis therapy and Rituximab, a chimeric (murine and human) anti-CD20 antibody used in AB0 incompatible kidney transplants. Severe infusion related reactions due to the administration of Rituximab are reported in 10% of patients. These adverse reactions may hinder the completion of the desensitization protocol. Read More

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December 2017
3 Reads

Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy.

Int J Nephrol 2017 22;2017:8549502. Epub 2017 Oct 22.

A. Tsyb Medical Radiological Research Centre, Branch of the National Medical Research Radiological Centre of The Ministry of Health of The Russian Federation, 10 Zhukov St., Obninsk, Kaluga 249036, Russia.

Study Objective: To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC).

Materials And Methods: 41 mRCC patients after nephrectomy received nivolumab ( = 23) and interferon- ( = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF-, and erythropoietin. Read More

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October 2017
8 Reads

Chloride Intracellular Channel 4 Overexpression in the Proximal Tubules of Kidneys from the Spontaneously Hypertensive Rat: Insight from Proteomic Analysis.

Nephron 2018 7;138(1):60-70. Epub 2017 Nov 7.

Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Background: Hypertensive nephropathy, a leading cause of declining kidney function, is a multifactorial process not well understood. In order to elucidate biological processes and identify novel macromolecular components crucially involved in the process of kidney damage, the application of system biology approaches, like proteomics, is required.

Methods: Proteomic studies were performed using the renal parenchyma of spontaneously hypertensive rats (SHR) and their normotensive Wistar Kyoto controls. Read More

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November 2017
6 Reads

Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis.

Clin Exp Nephrol 2018 Jun 11;22(3):629-637. Epub 2017 Nov 11.

Department of Nephrology and Laboratory Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Nephrosclerosis is an increasingly reason for dialysis in Japan. However, kidney biopsy specimens for hypertensive nephrosclerosis are very limited; thus, the pathologic evaluation of hypertensive nephrosclerosis currently remains unclear.

Methods: Clinical and pathologic data of a total of 184 biopsy-confirmed hypertensive nephrosclerosis patients were collected from 13 centers throughout Japan. Read More

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June 2018
10 Reads

Malignant Hypertension Complicated By Renal Thrombotic Micro Angiopathy: Role Of Adam 13 Mutational Analyses.

J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):502-505

Department of Internal Medicine and Histopathology, Dubai Hospital, Dubai, U.A.E.

We report a case of a 38-year-old U.A.E national who presented with malignant hypertension and features of thrombotic microangiopathy. Read More

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October 2017
5 Reads

Bile acid receptors and the kidney.

Curr Opin Nephrol Hypertens 2018 01;27(1):56-62

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Purpose Of Review: Bile acids act as activating signals of endogenous renal receptors: the nuclear receptor farnesoid X receptor (FXR) and the membrane-bound G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5). In recent years, bile acids have emerged as important for renal pathophysiology by activating FXR and TGR5 and transcription factors relevant for lipid, cholesterol and carbohydrate metabolism, as well as genes involved in inflammation and renal fibrosis.

Recent Findings: Activation of bile acid receptors has a promising therapeutic potential in prevention of diabetic nephropathy and obesity-induced renal damage, as well as in nephrosclerosis. Read More

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January 2018
4 Reads

Warfarin-related nephropathy in a patient with renal pelvic cancer.

Clin Nephrol Case Stud 2017 3;5:5-8. Epub 2017 Feb 3.

Division of Internal Medicine, Mitsui Memorial Hospital, Tokyo, and.

An 83-year-old Japanese man had a history of chronic heart failure due to bradycardia-tachycardia syndrome. He was admitted to our hospital because of macrohematuria and acute kidney injury (AKI), which were detected by an urologist at an outpatient visit. He had a history of recurrent macrohematuria and transurethral resection of bladder tumors twice in the preceding 2 years. Read More

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February 2017
3 Reads

Aortic Dissection and Severe Renal Failure 6 Years After Kidney Transplantation.

Transplant Direct 2017 Sep 9;3(9):e202. Epub 2017 Aug 9.

Department of Nephrology, Institute of Transplantation, Urology and Nephrology, Nantes University Hospital, Nantes, France.

We report the case of a patient with long-term history of hypertension, presenting with transient neurological disorders and severe graft failure several years after kidney transplantation. Cause of end-stage renal disease was hypertensive nephrosclerosis. Chronic hemodialysis lasted for 1 year. Read More

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September 2017
19 Reads

Structural and Functional Changes in Human Kidneys with Healthy Aging.

J Am Soc Nephrol 2017 Oct 8;28(10):2838-2844. Epub 2017 Aug 8.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota; and

Aging is associated with significant changes in structure and function of the kidney, even in the absence of age-related comorbidities. On the macrostructural level, kidney cortical volume decreases, surface roughness increases, and the number and size of simple renal cysts increase with age. On the microstructural level, the histologic signs of nephrosclerosis (arteriosclerosis/arteriolosclerosis, global glomerulosclerosis, interstitial fibrosis, and tubular atrophy) all increase with age. Read More

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October 2017
9 Reads

Multiple small intestinal ulcers associated with protein-losing enteropathy secondary to cholesterol crystal embolism:a case report.

Nihon Shokakibyo Gakkai Zasshi 2017;114(8):1436-1445

Department of Histopathology and Cytology, Kyoto Second Red Cross Hospital.

A 78-year-old man with hypertension, nephrosclerosis, and angina pectoris visited his family doctor with a history of fatigue and leg edema. He had a history of percutaneous coronary intervention 5 years prior, and was taking low-dose aspirin. Blood tests revealed hypoalbuminemia, gastrointestinal Tc-HSA scintigraphy was positive, and alpha-1 antitrypsin clearance was high;therefore, the hypoalbuminemia was thought to be secondary to a protein-losing enteropathy. Read More

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January 2018
29 Reads

Hyponatremia in refractory congestive heart failure patients treated with icodextrin-based peritoneal dialysis: A case series.

Nefrologia 2018 Jan - Feb;38(1):87-91. Epub 2017 Jul 29.

Nephrology and Hypertension Institute, Sheba Medical Center and Sackler Faculty of Medicine, Tel-Hashomer, Israel.

Severe congestive heart failure (CHF) patients are prone to hyponatremia. Peritoneal dialysis (PD) is increasingly used for long-term management of refractory CHF patients. The glucose polymer icodextrin was proposed to be a good option for fluid removal in such patients. Read More

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October 2018
24 Reads

Ferrokinetics is associated with the left ventricular mass index in patients with chronic kidney disease.

Acta Cardiol 2017 Aug 14;72(4):460-466. Epub 2017 Jul 14.

a Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital , Nagoya , Japan.

Background Patients with chronic kidney disease (CKD) often have the complication of anaemia. Usage of an erythropoietin-stimulating agent accelerates iron deficiency because it promotes iron utilization. Recently, iron administration was reported to be effective for patients with cardiac failure. Read More

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August 2017
7 Reads

[Renal diseases related to MYH9 disorders].

G Ital Nefrol 2017 Apr;34(2):40-57

UOC Nefrologia e Dialisi, P.O. San Giovanni di Dio, Agrigento, Italia.

Mutations in MYH9 gene encoding the nonmuscle myosin heavy chain IIA (NMMHC-IIA) are related to a number of rare autosomal-dominant disorders which has been known as May-Hegglin disease, Sebastian syndrome, Fechtner syndrome and Epstein syndrome. Their common clinical features are congenital macrothrombocytopaenia and polymorphonuclear inclusion bodies, in addition to a variable risk of developing proteinuria, chronic kidney disease progressing toward end stage, sensorineural deafness and presenile cataracts. The term MYH9 related disease (MYH9-RD) describes the variable expression of a single illness encompassing all previously mentioned hereditary disorders. Read More

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April 2017
15 Reads

Renal involvement in leprosy: evaluation of patients in Turkey.

Postepy Dermatol Alergol 2017 Jun 29;34(3):240-244. Epub 2017 May 29.

Department of Dermatology, Medical Faculty, Balikesir University, Balikesir, Turkey.

Introduction: Renal involvement in leprosy has previously been described in the literature and can include amyloidosis, glomerulonephritis, nephrosclerosis, tubulointerstitial nephritis, and granulomas.

Aim: To evaluate renal involvement in Turkish patients with leprosy.

Material And Methods: In total, 32 patients with lepromatous leprosy but without any co-morbidities and 35 healthy control subjects were evaluated for renal involvement at the Elazig Training and Research Hospital in Turkey. Read More

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June 2017
8 Reads

Cuff extrusion in peritoneal dialysis: single-centre experience with the cuff-shaving procedure in five patients over a 4-year period.

Clin Kidney J 2017 Feb 16;10(1):131-134. Epub 2016 Sep 16.

Division of Nephrology, Department of Medicine, Sykehuset i Vestfold, Tonsberg, Norway.

Catheter-related infections in peritoneal dialysis (PD) remain a significant complication, and some patients with recurrent exit-site (ESI) and/or tunnel infections may experience external cuff extrusion. In these cases, cuff-shaving has been described as a possible course of treatment. During a 4-year period, there were 44 patients with PD at our department; all received double-cuffed Tenckhoff catheters. Read More

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February 2017
25 Reads

Single-Nephron Glomerular Filtration Rate in Healthy Adults.

N Engl J Med 2017 06;376(24):2349-2357

From the Divisions of Nephrology and Hypertension (A.D., J.M., L.O.L., J.C.L., A.D.R.), Biomedical Statistics and Informatics (J.J.L.), and Epidemiology (A.D.R.) and the Department of Laboratory Medicine and Pathology (J.C.L., M.P.A.), Mayo Clinic, Rochester, MN; the Department of Nephrology, Cleveland Clinic, Cleveland (E.P.); and the Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (R.J.G.).

Background: The glomerular filtration rate (GFR) assesses the function of all nephrons, and the single-nephron GFR assesses the function of individual nephrons. How the single-nephron GFR relates to demographic and clinical characteristics and kidney-biopsy findings in humans is unknown.

Methods: We identified 1388 living kidney donors at the Mayo Clinic and the Cleveland Clinic who underwent a computed tomographic (CT) scan of the kidney with the use of contrast material and an iothalamate-based measurement of the GFR during donor evaluation and who underwent a kidney biopsy at donation. Read More

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June 2017
15 Reads

Malignant hypertension as a rare cause of thrombotic microangiopathy.

BMJ Case Rep 2017 Jun 8;2017. Epub 2017 Jun 8.

Internal Medicine, Western Michigan University School of Medicine, Kalamazoo, Michigan, USA.

Malignant hypertension can occasionally be associated with microangiopathic haemolytic anaemia. A 38-year-old male presented with nausea, vomiting, loss of appetite and oliguria for 2 weeks. He was diagnosed with hypertensive emergency with cardiac and renal dysfunction. Read More

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June 2017
30 Reads

Causes of nephrotic syndrome and nephrotic-range proteinuria are different in adult Chinese patients: A single centre study over 33 years.

Nephrology (Carlton) 2018 Jun;23(6):565-572

Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, China.

Aim: The reported causes of nephrotic syndrome (NS) varies between different countries. Less is known about the causes of nephrotic-range proteinuria (NPU). We aimed to evaluate the underlying causes of NS and NPU. Read More

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June 2018
17 Reads

Risk of Thyroid Cancer Among Solid Organ Transplant Recipients.

Am J Transplant 2017 Nov 30;17(11):2911-2921. Epub 2017 May 30.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Solid organ transplant recipients have an elevated incidence of thyroid cancer. We evaluated a wide range of potential risk factors in a cohort of 229 300 U.S. Read More

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November 2017
5 Reads

Obesity and kidney disease.

J Bras Nefrol 2017 Mar;39(1):65-69

Universidade Federal da Bahia, Brazil.

Obesity has been pointed out as an important cause of kidney diseases. Due to its close association with diabetes and hypertension, excess weight and obesity are important risk factors for chronic kidney disease (CKD). Obesity influences CKD development, among other factors, because it predisposes to diabetic nephropathy, hypertensive nephrosclerosis and focal and segmental glomerulosclerosis. Read More

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March 2017
11 Reads

Restricted nutrition-induced low birth weight, low number of nephrons and glomerular mesangium injury in Japanese quail.

J Dev Orig Health Dis 2017 Jun 6;8(3):287-300. Epub 2017 Feb 6.

2Institute of Nephrology and Department of Physiology,Niigata University Graduate School of Medical and Dental Sciences,Niigata,Japan.

Insufficient nutrition during the perinatal period causes structural alterations in humans and experimental animals, leading to increased vulnerability to diseases in later life. Japanese quail, Coturnix japonica, in which partial (8-10%) egg white was withdrawn (EwW) from eggs before incubation had lower birth weights than controls (CTs). EwW birds also had reduced hatching rates, smaller glomeruli and lower embryo weight. Read More

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June 2017
6 Reads

Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.

Sci Rep 2017 02 2;7:41572. Epub 2017 Feb 2.

Department of Medicine, Division of Nephrology, McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.

Endoplasmic reticulum (ER) stress is implicated in chronic kidney disease (CKD) development in patients and in animal models. Here we show that ER stress inhibition through 4-phenylbutyric acid (4-PBA) administration decreases blood pressure, albuminuria, and tubular casts in an angiotensin II/deoxycorticosterone acetate/salt murine model of CKD. Lower albuminuria in 4-PBA-treated mice was associated with higher levels of cubilin protein in renal tissue membrane fractions. Read More

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February 2017
5 Reads