507 results match your criteria Nephron Experimental Nephrology[Journal]


Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats.

Nephron Exp Nephrol 2015 Jan 9. Epub 2015 Jan 9.

Department of Emergency and Critical Care Medicine School of Medicine, Keio University, Tokyo, Japan.

Background: The present study aimed at investigating the effect of a novel antioxidant, hydrogen (H) gas, on the severity of contrast-induced acute kidney injury (CIAKI) in a rat model. Methods: CIAKI was induced in rats by intravenous injection of a contrast medium, Ioversol, in addition to reagents inhibiting prostaglandin and nitric oxide synthesis. During the injection of these reagents, the rats inhaled H gas or control gas. Read More

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https://www.karger.com/Article/FullText/369068
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http://dx.doi.org/10.1159/000369068DOI Listing
January 2015
5 Reads

Polyuria in Hantavirus Infection Reflects Disease Severity and Is Associated with Prolonged Hospital Stay: A Systematic Analysis of 335 Patients from Southern Germany.

Nephron Exp Nephrol 2014 Dec 13. Epub 2014 Dec 13.

Division of Nephrology, Department of Internal Medicine, Robert Bosch Hospital, Stuttgart, Germany.

Background/Aims: Puumala virus (PUUV) infection leads to nephropathia epidemica (NE), especially in endemic areas in Central Europe. The clinical course of NE is characterized by acute kidney injury (AKI) with thrombocytopenia followed by polyuria to a different degree. The prevalence of polyuria and its associated risk factors have not been reported in a large cohort of NE patients. Read More

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http://dx.doi.org/10.1159/000368934DOI Listing
December 2014
8 Reads

Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells.

Nephron Exp Nephrol 2014 Dec 17. Epub 2014 Dec 17.

Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, S.C., USA.

Objective: Since peritoneal dialysis causes peritoneal fibrosis, we examined how glucose (osmotic factor), mannitol (osmotic control), and angiotensin II (AngII) regulate proinflammatory cyclooxygenase 2 (COX-2) in primary rat peritoneal mesothelial cells. Materials and Methods: For this study, we used the following material (n = 4-8 cell lines): cells, passages 1-2; I-AngII receptor surface binding (AT1R antagonist losartan, AT2R antagonist PD123319; both 10 µM); intracellular calcium probe calcium-5; COX-2 immunoblotting (β-actin normalized); real-time PCR of COX-2 gene PTGS2, and NF-κB inhibitor Ro-1069920 (5 µM). Results: AngII surface receptors were predominantly AT1R (minimally AT2R). Read More

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https://www.karger.com/Article/FullText/368673
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http://dx.doi.org/10.1159/000368673DOI Listing
December 2014
5 Reads

Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers.

Nephron Exp Nephrol 2014 Dec 6. Epub 2014 Dec 6.

Division of Nephrology-Hypertension, O'Brien Kidney Center, University of California San Diego, La Jolla, Calif., USA.

Background: Kidney ischemia-reperfusion is a form of acute kidney injury resulting in a cascade of cellular events prompting rapid cellular damage and suppression of kidney function. A cellular response to ischemic stress is the activation of AMP-activated protein kinase (AMPK), where AMPK induces a number of homeostatic and renoprotective mechanisms, including autophagy. However, whether autophagy is beneficial or detrimental in ischemia-reperfusion remains controversial. Read More

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http://dx.doi.org/10.1159/000368932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458239PMC
December 2014
48 Reads

Wnt5a is necessary for normal kidney development in zebrafish and mice.

Nephron Exp Nephrol 2014 19;128(1-2):80-8. Epub 2014 Nov 19.

Department of Medicine, Eastern Virginia Medical School, Norfolk, Va., USA.

Background: Wnt5a is important for the development of various organs and postnatal cellular function. Little is known, however, about the role of Wnt5a in kidney development, although WNT5A mutations were identified in patients with Robinow syndrome, a genetic disease which includes developmental defects in kidneys. Our goal in this study was to determine the role of Wnt5a in kidney development. Read More

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http://dx.doi.org/10.1159/000368411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382204PMC
August 2015
7 Reads

Protective effects of relaxin against cisplatin-induced nephrotoxicity in rats.

Nephron Exp Nephrol 2014 11;128(1-2):9-20. Epub 2014 Nov 11.

Department of Clinical Nutrition, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.

Background: Cisplatin (CDDP)-induced acute kidney injury (AKI) involves pro-inflammatory responses, apoptosis of renal tubular epithelial cells and vascular damage. AKI increases the risk of chronic kidney disease. Relaxin (RLX) has anti-apoptotic and anti-fibrosis properties. Read More

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https://www.karger.com/Article/FullText/365852
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http://dx.doi.org/10.1159/000365852DOI Listing
August 2015
4 Reads

Multiple mechanisms in renal artery stenosis-induced renal interstitial fibrosis.

Nephron Exp Nephrol 2014 8;128(1-2):57-66. Epub 2014 Nov 8.

Department of Nephrology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.

Background/aims: Renal artery stenosis (RAS), which may lead to renal fibrosis, is a common cause of end-stage renal disease in elderly patients. However, the potential mechanisms leading to the development of renal fibrosis and atrophy have not been clarified.

Methods: A two-kidney, one-clip Goldblatt mouse model was established in the present study. Read More

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http://dx.doi.org/10.1159/000366481DOI Listing
August 2015
17 Reads

Increased macrophage activation inhibited by tacrolimus in the kidney of diabetic rats.

Nephron Exp Nephrol 2014 5;128(1-2):46-56. Epub 2014 Nov 5.

Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, PR China.

Background/aims: Accumulating evidence suggests that macrophage-induced inflammation may be the mechanism of development and progression of diabetic nephropathy. A previous study by our group has shown that tacrolimus, like cyclosporin A, has a renoprotective effect in diabetic rats. The present study aimed to elucidate the underlying molecular events. Read More

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http://dx.doi.org/10.1159/000366446DOI Listing
August 2015
5 Reads

IL-10 deficiency increases renal ischemia-reperfusion injury.

Nephron Exp Nephrol 2014 31;128(1-2):37-45. Epub 2014 Oct 31.

Division of Nephrology, Department of Medicine, Nanjing, China.

Background: Renal ischemia-reperfusion (IR) injury is a frequent cause of acute kidney injury, which results in high morbidity and mortality. Inflammation is an important factor that is involved in kidney repair after renal IR injury. IL-10 is a potent anti-inflammatory cytokine that inhibits inflammatory pathways, but the role of IL-10 in repairing renal IR injury is not known. Read More

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https://www.karger.com/Article/FullText/366130
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http://dx.doi.org/10.1159/000366130DOI Listing
August 2015
11 Reads

Macrophage depletion ameliorates glycerol-induced acute kidney injury in mice.

Nephron Exp Nephrol 2014 5;128(1-2):21-9. Epub 2014 Nov 5.

Biomedical Research Institute, Gyeongsang National University, Jinju, Republic of Korea.

Background: This study was conducted to elucidate the role of renal macrophages in the development of acute kidney injury (AKI) in a glycerol (Gly)-induced rhabdomyolysis mouse model.

Methods: The experimental model of rhabdomyolysis requires injecting 50% Gly (10 ml/kg) intramuscularly into mice. Control mice were injected into the tail vein with the liposomal vehicle. Read More

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https://www.karger.com/Article/FullText/365851
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http://dx.doi.org/10.1159/000365851DOI Listing
August 2015
5 Reads

Indoxyl sulfate induces IL-6 expression in vascular endothelial and smooth muscle cells through OAT3-mediated uptake and activation of AhR/NF-κB pathway.

Nephron Exp Nephrol 2014 5;128(1-2):1-8. Epub 2014 Nov 5.

Department of Advanced Medicine for Uremia, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background/aims: Interleukin-6 (IL-6) is one of the inflammation biomarkers with highest predictive value for outcome in chronic kidney disease (CKD) patients. The present study aimed to determine the effects of indoxyl sulfate (IS) on IL-6 expression in vascular cells.

Methods: IS was administered to normo- and hypertensive rats. Read More

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http://dx.doi.org/10.1159/000365217DOI Listing
August 2015
14 Reads

Role of reactive oxygen species-mediated endoplasmic reticulum stress in contrast-induced renal tubular cell apoptosis.

Nephron Exp Nephrol 2014 24;128(1-2):30-6. Epub 2014 Oct 24.

Division of Nephrology, Department of Internal Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Renal tubular cell apoptosis is a key mechanism of contrast-induced acute kidney injury. It has been reported that endoplasmic reticulum (ER) stress is the underlying mechanism of high osmolar contrast-induced renal tubular cell apoptosis. Whether ER stress is involved in low osmolar contrast-induced renal tubular cell injury remains unclear. Read More

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http://dx.doi.org/10.1159/000366063DOI Listing
August 2015
6 Reads

Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure.

Nephron Exp Nephrol 2014 24;128(1-2):67-79. Epub 2014 Oct 24.

Department of Physiology I, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: Leukocytes, such as lymphocytes and macrophages, predominantly express delayed rectifier K(+) channels (Kv1.3) in their plasma membranes. In our previous study, the overexpression of these channels in leukocytes was strongly associated with their proliferation in kidneys and the progression of renal fibrosis in advanced-stage chronic renal failure (CRF). Read More

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http://dx.doi.org/10.1159/000368080DOI Listing
August 2015
8 Reads

Recent advances in animal models of diabetic nephropathy.

Nephron Exp Nephrol 2014 12;126(4):191-5. Epub 2014 Jul 12.

Centres for Inflammation Research, University of Edinburgh, Edinburgh, UK.

Diabetic nephropathy (DN) is the single most common cause of end-stage kidney disease. Therefore, it is imperative that novel therapies are developed. Progress has been hindered, however, by the lack of robust animal models. Read More

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http://dx.doi.org/10.1159/000363300DOI Listing
April 2015
5 Reads

Ischemia/reperfusion of unilateral kidney exaggerates aging-induced damage to the heart and contralateral kidney.

Nephron Exp Nephrol 2014 3;126(4):183-90. Epub 2014 Jul 3.

Research Division of CKD and Dialysis, Tohoku University Graduate School of Medicine, Sendai, Japan.

Aims: We aimed to determine the impact of aging on ischemic acute kidney injury, especially in terms of the pathological mechanisms of kidney and heart crosstalk.

Method: The effects of 45 min of unilateral ischemic reperfusion (IR) of the renal artery on the contralateral kidney and heart were histologically assessed in 7- and 40-week-old SD rats after 7 days.

Results: Glomerular sclerosis, interstitial fibrosis and numbers of ED1 cells were significantly increased in the contralateral kidneys of the 40-, but not the 7-week-old rats. Read More

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http://dx.doi.org/10.1159/000362555DOI Listing
April 2015
11 Reads

Impact of chronic kidney disease on myocardial blood flow regulation in dogs.

Nephron Exp Nephrol 2014 7;126(4):175-82. Epub 2014 Jun 7.

Department of Medicine, Faculty of Medicine, Laval University, Quebec, Que., Canada.

Background/aims: Chronic kidney disease (CKD) increases cardiovascular risk possibly due to coronary microvessel dysfunction and impaired myocardial flow reserve. This study investigated the effects of CKD on the regulation and transmural distribution of myocardial blood flow along with oxygen demand during intravenous dobutamine-induced increases in cardiac work.

Methods: CKD was produced in dogs by a two-stage subtotal nephrectomy (kidney ablation-infarction model). Read More

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http://dx.doi.org/10.1159/000362090DOI Listing
April 2015
7 Reads

Heat-shock proteins and acute ischaemic kidney injury.

Nephron Exp Nephrol 2014 6;126(4):167-74. Epub 2014 Jun 6.

MRC Centre for Inflammation Research, Tissue Injury and Repair Group, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, UK.

The incidence of acute kidney injury due to ischaemia-reperfusion injury (IRI) is rising but effective treatments and preventative approaches are currently lacking. IRI is also an inevitable consequence of kidney transplantation and significantly contributes to delayed graft function. Heat-shock proteins (Hsps) are highly conserved and ubiquitously expressed molecular chaperones that help maintain and restore normal cellular function in the kidney following IRI. Read More

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http://dx.doi.org/10.1159/000363323DOI Listing
April 2015
8 Reads

Hydrogen sulfide ameliorates high-glucose toxicity in rat peritoneal mesothelial cells by attenuating oxidative stress.

Nephron Exp Nephrol 2014 22;126(3):157-65. Epub 2014 May 22.

Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, PR China.

Background/aims: Continuous exposure of the peritoneal membrane to high-glucose (HG) peritoneal dialysis fluids (PDFs) can produce peritoneal mesothelial cells (PMCs) injury. It has been demonstrated that hydrogen sulfide (H2S), the third endogenous gaseous mediator identified after nitric oxide and carbon monoxide, exhibits a potent protective effect on cell activity. We studied the toxic effects of HG PDFs and their reversal by H2S on cultures of rat PMCs. Read More

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http://dx.doi.org/10.1159/000358436DOI Listing
February 2015
6 Reads

Endoplasmic reticulum stress induces epithelial-mesenchymal transition through autophagy via activation of c-Src kinase.

Nephron Exp Nephrol 2014 22;126(3):127-40. Epub 2014 May 22.

Department of Internal Medicine, Asan Medical Center, University of Ulsan, Seoul, Korea.

Background: Endoplasmic reticulum (ER) stress has been implicated in inducing epithelial-mesenchymal transition (EMT). ER stress is also known to induce autophagy. However, it is unclear whether ER stress-induced autophagy contributes to EMT. Read More

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http://dx.doi.org/10.1159/000362457DOI Listing
February 2015
7 Reads

Synergistic effects of leflunomide and benazepril in streptozotocin-induced diabetic nephropathy.

Nephron Exp Nephrol 2014 16;126(3):148-56. Epub 2014 May 16.

Nephrology and Dialysis Unit, Department of Internal Medicine, Yanbian University Hospital, Yanji, Jilin Province, PR China.

Background: Leflunomide (LEF) and benazepril have renoprotective effects on diabetic nephropathy (DN) through their anti-inflammatory and anti-fibrotic activities. This study investigated whether combined treatment using LEF and benazepril affords superior protection compared with the respective monotherapies.

Methods: Diabetes was induced with streptozotocin (STZ, 65 mg/kg) by intraperitoneal injection in male Wistar rats. Read More

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http://dx.doi.org/10.1159/000362556DOI Listing
February 2015
18 Reads

Inhibitor of differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease.

Nephron Exp Nephrol 2014 16;126(3):141-7. Epub 2014 May 16.

Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Va., USA.

Background: Lipoprotein abnormalities are associated with a rapid decline in renal function in patients of chronic kidney disease. In addition, hyperlipidemia is associated with an increased risk of developing renal insufficiency. The underlying molecular mechanisms for these clinical findings are unclear. Read More

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http://dx.doi.org/10.1159/000362452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113412PMC
February 2015
13 Reads

Renal bioengineering with scaffolds generated from human kidneys.

Nephron Exp Nephrol 2014 19;126(2):119. Epub 2014 May 19.

Wake Forest School of Medicine, Winston-Salem, N.C., USA.

Background: In 2012, about 16,487 people received kidney transplants in the USA whereas 95,022 candidates were on the waiting list at the end of the year. Moreover, more than 2,600 kidneys procured annually for transplantation are discarded for a variety of reasons. We hypothesize that this pool of discarded kidneys could in part meet the growing, urgent need for transplantable kidneys using current methods for organ bioengineering and regeneration and surgical transplantation. Read More

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http://dx.doi.org/10.1159/000360684DOI Listing
March 2015
14 Reads

Renal bioengineering with scaffolds generated from rat and pig kidneys.

Nephron Exp Nephrol 2014 19;126(2):113. Epub 2014 May 19.

IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Background: Chronic kidney disease (CKD) is a global public health issue with an estimated prevalence of 8-16% worldwide. End-stage renal disease eventually develops every year in 0.15-0. Read More

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http://dx.doi.org/10.1159/000360683DOI Listing
March 2015
3 Reads

Reforming the kidney starting from a single-cell suspension.

Nephron Exp Nephrol 2014 19;126(2):107. Epub 2014 May 19.

IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Background: Chronic kidney disease affects 5-7% of people worldwide. The increasing number of patients and the shortage of transplantable organs create an imperative need to develop new methods for generating kidney tissue.

Summary: Recent advances in our understanding of the developmental biology of the kidney, along with the establishment of novel methodologies in the field of regenerative medicine, have created significant potential for kidney regeneration. Read More

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http://dx.doi.org/10.1159/000360682DOI Listing
March 2015
6 Reads

Cellular and developmental strategies aimed at kidney tissue engineering.

Nephron Exp Nephrol 2014 19;126(2):101. Epub 2014 May 19.

Department of Pediatrics, University of California at San Diego, La Jolla, Calif., USA.

Background: With the rate of kidney disease on the rise, and a serious imbalance between the number of patients requiring a kidney transplant and the number of available donor kidneys, it is becoming increasingly important to develop alternative strategies to restore organ function to diminish the need for human donors.

Summary: We review the current progress and future directions of a subset of these strategies which are ultimately aimed towards bioengineering a functional, implantable, kidney-like tissue construct or organoid that might be genetically matched to the patient.

Key Messages: By combining the knowledge about normal kidney development with the rapidly growing knowledge in the field of cell differentiation and transdifferentiation, there is hope that partial or complete kidney function can be restored in patients with kidney disease - including genetic disorders, acute kidney injury, or chronic kidney disease - with tissue-engineered construct(s). Read More

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http://dx.doi.org/10.1159/000360680DOI Listing
March 2015
2 Reads

Role of parietal epithelial cells in kidney injury: the case of rapidly progressing glomerulonephritis and focal and segmental glomerulosclerosis.

Nephron Exp Nephrol 2014 19;126(2):97. Epub 2014 May 19.

Nephrology and Clinical Immunology, Medizinische Klinik II, University Hospital of the RWTH Aachen University, Aachen, Germany.

Background: Millions of people are affected by irreversible loss of renal function and thus by a significantly increased cardiovascular risk. In this context, the parietal epithelial cells (PECs) of the glomerulus have attracted increasing attention in recent years. So far, they have been ascribed 2 major functions: (1) PECs may act as intrinsic progenitor cells to replenish podocytes and/or proximal tubular cells and (2) a major role of PECs has been proposed in 2 glomerular disease entities [i. Read More

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http://dx.doi.org/10.1159/000360677DOI Listing
March 2015
7 Reads

Drugs to foster kidney regeneration in experimental animals and humans.

Nephron Exp Nephrol 2014 19;126(2):91. Epub 2014 May 19.

IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Background: The incidence of kidney diseases is increasing worldwide and they are emerging as a major public health problem. Once mostly considered inexorable, renal disease progression can now be halted and lesions can even regress with drugs such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type I receptor blockers, indicating the possibility of kidney repair.

Summary: The discovery of renal progenitor cells lining the Bowman capsule of adult rat and human kidneys has shed light on the mechanism of repair by ACEi. Read More

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http://dx.doi.org/10.1159/000360675DOI Listing
March 2015
5 Reads

Can kidney regeneration be visualized?

Nephron Exp Nephrol 2014 19;126(2):86. Epub 2014 May 19.

Department of Physiology and Biophysics, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, Calif., USA.

Background: Various cell types, including podocytes and parietal epithelial cells, play important roles in the development and progression of glomerular kidney diseases, albuminuria, and glomerulosclerosis. Besides their role in renal pathologies, glomerular cells have emerging new functions in endogenous repair mechanisms. A better understanding of the dynamics of the glomerular environment and cellular composition in an intact living kidney is critically important for the development of new regenerative therapeutic strategies for kidney diseases. Read More

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http://dx.doi.org/10.1159/000360673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118422PMC
March 2015
33 Reads

Restoring the function of a diseased kidney via its microvasculature.

Authors:
Leon G Fine

Nephron Exp Nephrol 2014 19;126(2):82. Epub 2014 May 19.

Cedars-Sinai Medical Center and University of California at Los Angeles, Los Angeles, Calif., USA.

Background: Based upon observations which indicate that chronic intrarenal hypoxia and microvascular obliteration play an important role in the pathogenesis of renal scarring and loss of function, the idea is presented that restoration of kidney structure and function by arresting microvascular drop-out and restoring the interstitial capillary network could be a feasible approach to regeneration of a diseased kidney. This paper addresses the reasoning behind this possibility.

Summary: A 'unifying vasculogenic hypothesis' is discussed which proposes that, in hypoxic nephrons which retain poorly functioning vascular and epithelial elements, the disease process can be slowed or arrested, and nephrons regenerated, by adoptive transfer of endothelial progenitor cells to restore interstitial and glomerular vascular integrity. Read More

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http://dx.doi.org/10.1159/000360672DOI Listing
March 2015
2 Reads

Tubular regeneration: when can the kidney regenerate from injury and what turns failure into success?

Nephron Exp Nephrol 2014 19;126(2):76. Epub 2014 May 19.

Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.

Background: The most common intrarenal cause for acute kidney injury/renal failure is tubular damage. The kidney tubules are arranged as compartments of cellular mosaics to perform their functions, and at rest almost a fifth of the human ATP consumption is allotted to the reabsorption of substances from the filtrate, rendering especially the proximal tubules highly sensitive to oxygen and/or nutrient deprivation. Normally mitotically quiescent, the tubular epithelium shows a brisk regenerative response following injury if supportive care is offered, allowing functional restoration. Read More

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http://dx.doi.org/10.1159/000360671DOI Listing
March 2015
12 Reads

Glomerular regeneration: when can the kidney regenerate from injury and what turns failure into success?

Nephron Exp Nephrol 2014 19;126(2):70. Epub 2014 May 19.

Excellence Centre for Research, Transfer and High Education for the Development of De Novo Therapies (DENOTHE), University of Florence, Florence, Italy.

Background: For many years, the glomerulus was considered incapable of regeneration. However, experimental and clinical evidence challenged this concept and showed that glomerular injury and even glomerulosclerosis can undergo regression under certain circumstances. The problem with glomerular regeneration is centered around the podocyte, a highly specialized cell that is the critical constituent of the glomerular filtration barrier. Read More

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http://dx.doi.org/10.1159/000360669DOI Listing
March 2015
13 Reads

Cell therapy for kidney injury: different options and mechanisms--kidney progenitor cells.

Authors:
Kenji Osafune

Nephron Exp Nephrol 2014 19;126(2):64. Epub 2014 May 19.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Background: Since no specific or radical treatments have yet been established for acute kidney injury (AKI), the development of cell transplantation therapy using renal progenitors is desirable as a new therapeutic option for AKI. The recent advances in developmental biology, stem cell biology, and nephrology have led to an increased availability of renal progenitors from multiple sources.

Summary: Four main sources of renal progenitors have been described so far: isolation from (1) embryonic or (2) adult kidneys, (3) directed differentiation of pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), and (4) cellular reprogramming of fully differentiated adult renal cells. Read More

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http://dx.doi.org/10.1159/000360668DOI Listing
March 2015
7 Reads

Cell therapy for kidney injury: different options and mechanisms--mesenchymal and amniotic fluid stem cells.

Nephron Exp Nephrol 2014 19;126(2):59. Epub 2014 May 19.

IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Background: Acute kidney injury (AKI) is emerging as a public health problem in developing and developed countries. It affects up to 7% of hospitalized patients, with a higher prevalence in critical care units. Despite major advances in preventive strategies and support measures, the mortality rate among patients remains higher than 50%. Read More

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http://dx.doi.org/10.1159/000360667DOI Listing
March 2015
12 Reads

Kidney regeneration with stem cells: an overview.

Authors:
Takashi Yokoo

Nephron Exp Nephrol 2014 19;126(2):54. Epub 2014 May 19.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Background: Kidney regeneration is currently gaining considerable attention in place of kidney dialysis as the ultimate therapeutic strategy for renal failure. However, because of anatomical complications, the kidney is believed to be the hardest organ to regenerate. Such a complicated organ is virtually impossible to imagine being completely rebuilt de novo from stem cells. Read More

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http://dx.doi.org/10.1159/000360662DOI Listing
March 2015
8 Reads

Kidney regeneration in mammals.

Nephron Exp Nephrol 2014 19;126(2):50. Epub 2014 May 19.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tenn., USA.

Background: Several organs such as the skin and liver have a great capacity for regeneration. However, many approaches only delay the progression of end-stage kidney disease and do not achieve efficient long-term stabilization, let alone regeneration.

Summary: In mammals, the kidney has an innate but limited capacity for regeneration which can only modify the nephron structure and function but not increase the nephron number. Read More

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http://dx.doi.org/10.1159/000360661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337834PMC
March 2015
14 Reads

Kidney regeneration in fish.

Authors:
Alan J Davidson

Nephron Exp Nephrol 2014 19;126(2):45. Epub 2014 May 19.

Department of Molecular Medicine and Pathology, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

Background: Chronic and acute kidney injury damages nephrons, the blood filtering tubules in the kidney. Although mammalian kidneys can regenerate the tubular epithelium of the nephron, no new nephrons are made during adulthood. In contrast, fish are capable of growing nephrons de novo throughout their life. Read More

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http://dx.doi.org/10.1159/000360660DOI Listing
March 2015
5 Reads

Kidney development: an overview.

Nephron Exp Nephrol 2014 19;126(2):40. Epub 2014 May 19.

Oulu Center for Cell-Matrix Research, Biocenter and Infotech Oulu, Laboratory of Developmental Biology, Intelligent Systems, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.

Background: Kidney diseases are worldwide public health problems with a high cost and increasing incidence. By revealing the genetic and cellular mechanism behind mammalian kidney development, better diagnostic methods and novel therapies can be expected to be developed. The mammalian kidney is a typical organ that develops on the basis of sequential and reciprocal cell and tissue interactions. Read More

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https://www.karger.com/Article/FullText/360659
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http://dx.doi.org/10.1159/000360659DOI Listing
March 2015
2 Reads

Stem cells and regeneration in plants.

Authors:
Giovanni Sena

Nephron Exp Nephrol 2014 19;126(2):35. Epub 2014 May 19.

Department of Life Sciences, South Kensington Campus, Imperial College London, London, UK.

Background: Plants are characterized by indeterminate post-embryonic development that is evident, for example, in the continuous branching of shoots and roots. High competence to regenerate tissues is another consequence of such intrinsic developmental plasticity in plants. It has been suggested that specialized groups of cells within plant meristems should be compared to stem cells in animals, but the utility of this label in the context of post-embryonic plant development and regeneration is often debated. Read More

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http://dx.doi.org/10.1159/000360658DOI Listing
March 2015
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Introduction.

Authors:
Paola Romagnani

Nephron Exp Nephrol 2014 19;126(2):33. Epub 2014 May 19.

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http://dx.doi.org/10.1159/000360657DOI Listing
March 2015
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Contributions of endoplasmic reticulum stress and reactive oxygen species to renal injury in aldosterone/salt-induced rats.

Nephron Exp Nephrol 2014 7;126(1):25-32. Epub 2014 Mar 7.

Division of Nephrology, Huashan Hospital and Institute of Nephrology, Fudan University, Shanghai, China.

Background: Recent studies have suggested that aldosterone (Aldo) plays a key role in the pathogenesis of renal injury; however, the molecular mechanisms of Aldo-induced renal injury have not been characterized. This study was performed to test the hypothesis that reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress contribute to the pathogenesis of Aldo- and salt-induced renal injury.

Methods: Rats were uninephrectomized and treated with one of the following for 4 weeks: (1) vehicle, (2) vehicle + NaCl, (3) Aldo + NaCl or (4) Aldo + NaCl + N-acetyl-L-cysteine (NAC). Read More

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http://dx.doi.org/10.1159/000357777DOI Listing
December 2014
7 Reads

Local mineralocorticoid receptor activation and the role of Rac1 in obesity-related diabetic kidney disease.

Nephron Exp Nephrol 2014 28;126(1):16-24. Epub 2014 Feb 28.

Department of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background/aims: Obesity and diabetes are intimately interrelated, and are independent risk factors for kidney disease. Overactivation of mineralocorticoid receptor (MR) is implicated in end organ damage of both pathologies. But the underlying mechanism of MR activation in kidney remains uncertain. Read More

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http://dx.doi.org/10.1159/000358758DOI Listing
December 2014
5 Reads

Adoptive transfer of bone marrow dendritic cells failed to localize in the renal cortex and to improve renal injury in adriamycin nephropathy.

Nephron Exp Nephrol 2014 11;126(1):8-15. Epub 2014 Feb 11.

Department of Nephrology, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background And Aims: Murine bone marrow (BM) dendritic cells (DCs) can be modulated to be tolerogenic by cytokines, such as interleukin (IL)-10 and transforming growth factor (TGF)-β, and may play a regulatory role and sustain immune hemostasis in cognate kidney disease. However, it is unknown whether BM-DCs can be used to protect against renal injury in murine Adriamycin nephropathy (AN).

Methods: In this study, by adoptive in vivo transfer of BM-DCs, including immature DCs, mature DCs (lipopolysaccharide-stimulated DCs) and BM regulatory DCs (IL-10/TGF-β-modified DCs, DCregs), we addressed the potential benefits of BM-DCs in chronic kidney disease. Read More

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http://dx.doi.org/10.1159/000358086DOI Listing
December 2014
17 Reads
2 Citations
2.560 Impact Factor

Paricalcitol ameliorates epithelial-to-mesenchymal transition in the peritoneal mesothelium.

Nephron Exp Nephrol 2014 17;126(1):1-7. Epub 2014 Jan 17.

Division of Nephrology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, Korea.

Background: The purpose of the present study was to examine the effectiveness of paricalcitol for the prevention of epithelial-to-mesenchymal transition (EMT).

Materials And Methods: Human peritoneal mesothelial cells (HPMCs) were cultured in media containing transforming growth factor β1 (TGF-β1) with or without paricalcitol. Forty-two male Sprague-Dawley rats were divided into three groups. Read More

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http://dx.doi.org/10.1159/000357156DOI Listing
December 2014
7 Reads

Beneficial effects of short-term calorie restriction against cisplatin-induced acute renal injury in aged rats.

Nephron Exp Nephrol 2013 8;124(3-4):19-27. Epub 2014 Jan 8.

Department of Nephrology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China.

Background: The therapeutic use of the antineoplastic drug cisplatin (DDP) in the elderly is limited by its nephrotoxic effects. The aim of this study was to examine the effect of short-term calorie restriction (CR) on DDP-induced nephrotoxicity in aged rats.

Methods: A group of 25-month-old male Sprague-Dawley rats were divided into two groups: ad libitum (AL) and CR, which were fed 60% of the food consumed by AL rats for 8 weeks. Read More

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http://dx.doi.org/10.1159/000357380DOI Listing
October 2014
17 Reads

Prevalence of CD44-positive glomerular parietal epithelial cells reflects podocyte injury in adriamycin nephropathy.

Nephron Exp Nephrol 2013 8;124(3-4):11-8. Epub 2014 Jan 8.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background/aims: Recent study suggests that activation of parietal epithelial cells (PECs) contributes to pathogenesis of glomerulosclerosis and the activation marker CD44 increases in evolving glomerulosclerosis. Here we examined the pathogenic roles of CD44+ epithelial cells in mouse adriamycin nephropathy (ADRN), a representative rodent model for idiopathic focal segmental glomerulosclerosis (FSGS). We also evaluated whether the prevalence of CD44+ PECs reflects different levels of podocyte injuries. Read More

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http://dx.doi.org/10.1159/000357356DOI Listing
October 2014
7 Reads

Gene expression analysis and urinary biomarker assays reveal activation of tubulointerstitial injury pathways in a rodent model of chronic proteinuria (Doxorubicin nephropathy).

Nephron Exp Nephrol 2013 12;124(1-2):1-10. Epub 2013 Nov 12.

Safety Assessment, GlaxoSmithKline, Research Triangle Park, N.C., USA.

Background: Tubular atrophy and interstitial fibrosis are well-recognized sequelae of chronic proteinuria; however, little is known regarding the molecular pathways activated within tubulointerstitium in chronic proteinuric nephropathies.

Methods: To investigate the molecular mechanisms of proteinuria-associated tubulointerstitial (TI) disease, doxorubicin nephropathy was induced in rats. Progression of disease was monitored with weekly urinary biomarker assays. Read More

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http://dx.doi.org/10.1159/000355542DOI Listing
August 2014
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Gene expression analysis detected a low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice.

Nephron Exp Nephrol 2013 23;123(3-4):34-45. Epub 2013 Aug 23.

Drug Safety Research Laboratories, Astellas Pharma Inc., Osaka, Japan.

Background: ICR-derived glomerulonephritis (ICGN) strain is a novel inbred strain of mice with a hereditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice; however, the existence of other associative factors has been suggested.

Methods And Results: To identify additional associative factors and to better understand the onset mechanism of nephrotic syndrome in ICGN mice, we conducted a comprehensive gene expression analysis using DNA microarray. Read More

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http://dx.doi.org/10.1159/000354057DOI Listing
July 2014
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Tenc1-deficient mice develop glomerular disease in a strain-specific manner.

Nephron Exp Nephrol 2013 23;123(3-4):22-33. Epub 2013 Aug 23.

Laboratory of Animal Models for Human Diseases, National Institute of Biomedical Innovation, Ibaraki, Japan.

Background/aims: Tenc1 (also known as tensin2) is an integrin-associated focal adhesion molecule that is broadly expressed in mouse tissues including the liver, muscle, heart and kidney. A mouse strain carrying mutated Tenc1, the ICR-derived glomerulonephritis (ICGN) strain, develops severe nephrotic syndrome.

Methods: To elucidate the function of Tenc1 in the kidney, Tenc1(ICGN) was introduced into 2 genetic backgrounds, i. Read More

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http://dx.doi.org/10.1159/000354058DOI Listing
July 2014
6 Reads

Human unrestricted somatic stem cell administration fails to protect nude mice from cisplatin-induced acute kidney injury.

Nephron Exp Nephrol 2013 1;123(3-4):11-21. Epub 2013 Aug 1.

Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, Tehran, Iran.

Background: Kidney failure is a debilitating disorder with limited treatment options. The kidney-protective effects of stem cells have been vastly investigated and promising results have been achieved with various sources of stem cells. However, in spite of beneficial effects on other disease models, the renoprotective potential of human cord blood-derived unrestricted somatic stem cells (USSC) has not been examined so far. Read More

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http://dx.doi.org/10.1159/000353233DOI Listing
July 2014
12 Reads

15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells.

Nephron Exp Nephrol 2013 24;123(1-2):1-10. Epub 2013 Jul 24.

Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, Shanghai, PR China.

Background/aims: Inflammation is an unavoidable milieu for renal tubular cells during the development of renal tubulointerstitial fibrosis. It has been demonstrated that chemokines including monocyte chemoattractant protein-1 (MCP-1) and IL-8 are related to tubulointerstitial lesions. 15d-PGJ2 may modulate renal tubulointerstitial fibrosis progression via anti-inflammatory effects. Read More

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http://dx.doi.org/10.1159/000353232DOI Listing
March 2014
21 Reads