1,286 results match your criteria Nephron Clinical Practice[Journal]


Chronic kidney disease in disadvantaged populations.

Nephron Clin Pract 2014 16;128(3-4):292-6. Epub 2015 Jan 16.

Nephrology Service, Hospital Civil de Guadalajara, University of Guadalajara Health Sciences Center, Guadalajara, Mexico.

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http://dx.doi.org/10.1159/000369148DOI Listing
July 2015
2 Reads

Differential membrane expression of Toll-like receptors and intracellular cytokine induction in peripheral blood monocytes of patients with chronic kidney disease and diabetic nephropathy.

Nephron Clin Pract 2014 10;128(3-4):399-406. Epub 2015 Jan 10.

Department of Nephrology, School of Medicine, University of Ioannina, Ioannina, Greece.

Background: Toll-like receptors (TLRs) are key players in the innate immune system whose activation leads to an inflammatory response. Inflammation plays an important role in the pathogenesis of chronic kidney disease (CKD) and diabetes mellitus. The aim of our study was to assess the proinflammatory state of nondialysis CKD patients by evaluating the membrane expression of TLR2 and TLR4 and the intracellular IL-1β and IL-6 production in response to the ligand Pam3Cys-Ser-(Lys)4 (Pam3CSK4). Read More

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http://dx.doi.org/10.1159/000369815DOI Listing
July 2015
4 Reads

Correction of hyper- and hyponatraemia during continuous renal replacement therapy.

Nephron Clin Pract 2014 10;128(3-4):394-8. Epub 2015 Jan 10.

Department of Critical Care, Guy's & St. Thomas' NHS Foundation Hospital Trust, London, UK.

Background: Severe hyper- and hyponatraemia is associated with significant risks, yet its correction can also have serious consequences when implemented too fast or inadequately. The safe correction of serum sodium levels is particularly challenging when renal replacement therapy (RRT) is required.

Methods: Using 2 case scenarios, we aim to illustrate a simple method of correcting hyper- and hyponatraemia safely by step-wise manipulation of the dialysate/replacement fluid. Read More

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http://dx.doi.org/10.1159/000369347DOI Listing
July 2015
4 Reads
1 Citation

Ectopic expression of fatty acid-binding protein 4 in the glomerulus is associated with proteinuria and renal dysfunction.

Nephron Clin Pract 2014 9;128(3-4):345-51. Epub 2015 Jan 9.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background/aims: Fatty acid-binding proteins (FABPs) are a family of intracellular lipid chaperones. Among FABPs, FABP1 (liver FABP) is expressed in proximal tubular epithelial cells in the kidney, and urinary FABP1 has been reported to reflect damage of proximal tubular epithelial cells. However, roles of other FABP isoforms in renal pathologies have not been reported. Read More

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https://www.karger.com/Article/FullText/368412
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http://dx.doi.org/10.1159/000368412DOI Listing
July 2015
7 Reads

Association of de novo dipstick albuminuria with severe acute kidney injury in critically ill septic patients.

Nephron Clin Pract 2014 13;128(3-4):373-80. Epub 2015 Jan 13.

Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex., USA.

Background: Acute kidney injury (AKI) occurs frequently in septic patients. Albuminuria may play a role as an early marker of septic AKI. The potential association between de novo dipstick albuminuria (DA) and septic AKI has not been examined. Read More

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https://www.karger.com/Article/FullText/368902
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http://dx.doi.org/10.1159/000368902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362533PMC
July 2015
6 Reads

Therapeutic advances in the treatment of polycystic kidney disease.

Nephron Clin Pract 2014 6;128(3-4):297-302. Epub 2015 Jan 6.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass., USA.

The spectrum of polycystic kidney disease (PKD) comprises a family of inherited syndromes defined by renal cyst formation and growth, progressive renal function loss and variable extrarenal manifestations. The most common form, autosomal-dominant PKD is caused by mutations in one of two genes, PKD1 or PKD2. Recent developments in genomic and proteomic medicine have resulted in the discovery of novel genes implicated in the wide variety of less frequent, recessive PKD syndromes. Read More

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http://dx.doi.org/10.1159/000368244DOI Listing
July 2015
4 Reads

Effects of sleepiness on survival in Japanese hemodialysis patients: J-DOPPS study.

Nephron Clin Pract 2014 8;128(3-4):333-40. Epub 2015 Jan 8.

Dialysis Unit, University Hospital of the Ryukyus, Okinawa, Japan.

Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. Read More

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https://www.karger.com/Article/FullText/366479
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http://dx.doi.org/10.1159/000366479DOI Listing
July 2015
4 Reads

Predictors of hyperkalemia risk after hypertension control with aldosterone blockade according to the presence or absence of chronic kidney disease.

Nephron Clin Pract 2014 6;128(3-4):381-6. Epub 2015 Jan 6.

Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea.

Background/aims: Aldosterone antagonists have been proven to be efficient in the management of hypertension and the reduction of proteinuria; however, they are not widely used because of the risk of hyperkalemia. We assessed the predictors of hyperkalemia risk following hypertension control using aldosterone blockade in the presence or absence of chronic kidney disease (CKD).

Methods: A total of 6,575 patients with hypertension treated between January 1, 2000, and November 30, 2012, were evaluated for the safety of an aldosterone-blocking agent (spironolactone) added to preexisting blood pressure-lowering regimens. Read More

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http://dx.doi.org/10.1159/000369138DOI Listing
July 2015
6 Reads

Compared decline of residual kidney function in patients treated with automated peritoneal dialysis and continuous ambulatory peritoneal dialysis: a multicenter study.

Nephron Clin Pract 2014 8;128(3-4):352-60. Epub 2015 Jan 8.

Division of Nephrology, University Hospital A Coruña, A Coruña, Spain.

Background: There is controversy concerning the compared rates of decline of residual kidney function (RKF) in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and automated peritoneal dialysis (APD).

Objectives And Method: Following an observational, multicenter design, we studied 493 patients initiating peritoneal dialysis (PD) in four different Spanish units. We explored the effect of the PD modality on the rate of decline of RKF and the probability of anuria during follow-up. Read More

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https://www.karger.com/Article/FullText/368933
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http://dx.doi.org/10.1159/000368933DOI Listing
July 2015
6 Reads

The (99m)Tc-DTPA urinary clearance method may be preferable to the plasma disappearance method for assessing glomerular filtration rate in diabetic nephropathy.

Nephron Clin Pract 2014 8;128(3-4):367-72. Epub 2015 Jan 8.

Division of Nephrology, Department of Medicine, Western University, London, Ont., Canada.

Background: Isotopic glomerular filtration rate (iGFR) measurement is comparable to the inulin method. In this study, we compared urinary and plasma iGFR methodologies in patients with diabetic nephropathy.

Methods: A total of 147 patients from 3 sites in the Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) trial provided 213 sets of urine and blood collections, at baseline, 18 and 36 months. Read More

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https://www.karger.com/Article/FullText/368901
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http://dx.doi.org/10.1159/000368901DOI Listing
July 2015
12 Reads

Safety and effectiveness of a 2009 H1N1 vaccine in chronic kidney disease children.

Nephron Clin Pract 2014 19;128(3-4):341-4. Epub 2014 Dec 19.

Department of Pediatric Nephrology, School of Medicine, University of Uludag, Bursa, Turkey.

Background/aims: Influenza vaccination is the most effective method for preventing influenza infection and its complications. The risk groups are children with chronic kidney diseases (CKDs) such as children on peritoneal dialysis (PD) and hemodialysis (HD), predialysis CKD (pCKD) and renal transplant (RTx) patients and immunosuppressed children. The aim of the present study was to assess the safety and immunogenicity of a single administration of a monovalent inactivated pandemic (H1N1) 2009 vaccine in children with CKD. Read More

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http://dx.doi.org/10.1159/000368410DOI Listing
July 2015
6 Reads

Uremic toxins and their effects on multiple organ systems.

Nephron Clin Pract 2014 19;128(3-4):303-11. Epub 2014 Dec 19.

Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland.

Nearly all body organs and systems are affected by the toxicity of uremic compounds retained in the course of renal dysfunction. Knowledge about the origin, chemical structure and composition of the retained endogenous substances responsible for these symptoms is far from complete. Organic retention solutes present a great variety of properties which makes their accurate classification extremely difficult. Read More

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http://dx.doi.org/10.1159/000369817DOI Listing
July 2015
3 Reads

Complete low-intensity endurance training programme in haemodialysis patients: improving the care of renal patients.

Nephron Clin Pract 2014 17;128(3-4):387-93. Epub 2014 Dec 17.

Nephrology Department, Hospital de Terrassa, Consorci Sanitari Terrassa, Terrassa, Spain.

Background: Patients on haemodialysis (HD) have a decreased physical and functional capacity. Several studies have reported the beneficial effects of exercise on the physical, functional and psychological functioning of HD patients. Despite these results, exercise programmes on HD are not commonplace. Read More

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http://dx.doi.org/10.1159/000369253DOI Listing
July 2015
15 Reads

Biologic treatment in glomerular disease.

Nephron Clin Pract 2014 13;128(3-4):203-4. Epub 2014 Dec 13.

Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1159/000369646DOI Listing
July 2015
6 Reads

A low-salt diet increases the estimated net endogenous acid production in nondiabetic chronic kidney disease patients treated with angiotensin receptor blockade.

Nephron Clin Pract 2014 18;128(3-4):407-13. Epub 2014 Dec 18.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Background/aims: An acid-base imbalance precedes renal disease progression in patients with chronic kidney disease (CKD). Little is known about the effects of a low-salt diet (LSD) on net endogenous acid production (NEAP) levels in CKD patients using angiotensin receptor blockade.

Methods: We enrolled a total of 202 nondiabetic CKD patients who underwent an 8-week treatment with olmesartan from the original trial [Effects of Low Sodium Intake on the Antiproteinuric Efficacy of Olmesartan in Hypertensive Patients with Albuminuria (ESPECIAL) trial: NCT01552954]. Read More

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http://dx.doi.org/10.1159/000369558DOI Listing
July 2015
21 Reads

Mortality and cardiovascular morbidity associated with haemoglobin levels: a pooled analysis of randomised controlled trials.

Nephron Clin Pract 2014 5;128(3-4):323-32. Epub 2014 Dec 5.

Ospedale Alessandro Manzoni, Lecco, Italy.

Background/aims: Several randomised controlled trials (RCTs) have raised concerns about potential harm associated with erythropoiesis-stimulating agents (ESAs) in chronic kidney disease patients, especially when haemoglobin (Hb) levels above 13 g/dl were targeted. We report the relationship between Hb levels and outcomes in the methoxy polyethylene glycol-epoetin beta RCT programme.

Methods: We assessed the association between Hb and a composite end point, as well as its components [all-cause mortality, myocardial infarction (MI) or cerebrovascular events (CVE)], in multiple post hoc analyses of 9 prospective RCTs (3,405 chronic kidney disease patients). Read More

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http://dx.doi.org/10.1159/000366478DOI Listing
July 2015
23 Reads

Sex-dependent association between heart rate variability and pulse pressure in haemodialysis patients.

Nephron Clin Pract 2014 6;128(3-4):361-6. Epub 2014 Dec 6.

Cardiovascular Sciences Research Centre, St. George's University of London, UK.

Aims: Increased pulse pressure (PP) is associated with increased cardiovascular mortality in haemodialysis (HD) patients. Autonomic imbalance is common in HD patients and predisposes to sudden cardiac death, but its relationship to PP is unknown. We investigated the relationship between cardiac autonomic modulation assessed by heart rate variability (HRV) and PP in HD patients. Read More

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http://dx.doi.org/10.1159/000368436DOI Listing
July 2015
14 Reads

Chronic kidney disease and the ageing population.

Nephron Clin Pract 2014 9;128(3-4):319-22. Epub 2014 Dec 9.

University of Alberta, Edmonton, Alta., Canada.

Due to improvements in socioeconomic development and increased life expectancy, the proportion of older people in the general population is increasing worldwide. While this trend is something to celebrate, it also brings with it challenges for health care systems. One particular challenge is an increase in chronic kidney disease, the prevalence of which is higher in older people. Read More

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http://dx.doi.org/10.1159/000362458DOI Listing
July 2015
9 Reads

The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population.

Nephron Clin Pract 2014 28;128(1-2):192-200. Epub 2014 Nov 28.

Department of Renal Medicine, Royal Derby Hospital Derby, Derby, UK.

Background: Acute kidney injury (AKI) is common in hospitalised patients and is associated with adverse long-term consequences. There is an urgent need to understand these sequelae in general hospitalised patients utilising a prospective cohort-based approach. We aimed to test the feasibility of study methodology prior to commencing a large-scale study and investigate the effects of AKI on chronic kidney disease (CKD) progression and proteinuria. Read More

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http://dx.doi.org/10.1159/000368243DOI Listing
July 2015
9 Reads

Lower plasma sodium is associated with a microinflammatory state among patients with advanced chronic kidney disease.

Nephron Clin Pract 2014 28;128(3-4):312-8. Epub 2014 Nov 28.

Hospital Severo Ochoa, Leganés, Spain.

Background/aims: Lower serum sodium levels have been associated with increased mortality among patients with chronic kidney disease (CKD). Our aim was to analyze the independent factors associated with lower sodium levels among nondialysis patients with advanced CKD and to evaluate the evolution of these patients in comparison to those with higher plasma sodium over a 1-year period.

Methods: We included 72 patients with CKD stages 4 and 5 without clinically evident cardiopathy or liver disease. Read More

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http://dx.doi.org/10.1159/000368116DOI Listing
July 2015
37 Reads

Rituximab in systemic lupus erythematosus and lupus nephritis.

Nephron Clin Pract 2014 29;128(3-4):250-4. Epub 2014 Nov 29.

Imperial AHSC Lupus Centre, Department of Medicine, Imperial College London, London, UK.

Treatment options for systemic lupus erythematosus (SLE) and lupus nephritis (LN) have high associated morbidity and mortality. Side effects, particularly from long-term corticosteroid usage, limit patient adherence, with subsequent impacts on treatment efficacy. In addition, a subset of patients with SLE/LN fails to respond to current standard immunotherapy. Read More

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http://dx.doi.org/10.1159/000368585DOI Listing
July 2015
20 Reads

Rituximab in primary membranous nephropathy: first-line therapy, why not?

Nephron Clin Pract 2014 22;128(3-4):261-9. Epub 2014 Nov 22.

Icahn School of Medicine at Mount Sinai, New York, N.Y., USA.

The ideal treatment of patients with primary membranous nephropathy (MN) and persistent nephrotic syndrome (NS) is still a matter of debate. This is a major issue since these patients may progress to end-stage kidney disease (ESKD) in 5-10 years. Steroids, alkylating agents, and calcineurin inhibitors have been suggested to achieve NS remission and prevent ESKD in this population. Read More

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http://dx.doi.org/10.1159/000368589DOI Listing
July 2015
10 Reads

Complement and glomerular diseases.

Nephron Clin Pract 2014 19;128(3-4):238-42. Epub 2014 Nov 19.

King's College London, London, UK.

The complement pathway is a central part of the innate immune system and also modulates adaptive immunity. It is implicated in the pathogenesis of glomerular disease by a number of clinical findings. These include the presence of complement components in renal biopsy samples, decreases in circulating levels indicating consumption, the presence of autoantibodies to complement proteins and the association of genetic mutations with disease either in individuals or within families. Read More

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http://dx.doi.org/10.1159/000368591DOI Listing
July 2015
20 Reads

Limitations of standard immunosuppressive treatment in ANCA-associated vasculitis and lupus nephritis.

Nephron Clin Pract 2014 19;128(3-4):205-15. Epub 2014 Nov 19.

Department of Nephrology, 1st Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.

Introduction of the standard immunosuppressive treatment has dramatically changed the outcome of patients with both ANCA-associated vasculitis and lupus nephritis, transforming them from incurable diseases with very high short-term mortality to chronic debilitating diseases with much lower short-term, but still relatively high long-term, morbidity/mortality. Long-term morbidity with damage accumulating partly due to the adverse events of the available treatment (namely gonadal toxicity, malignancy, bone disease, cataracts, diabetes, and thromboembolic and cardiovascular disease) has become a major concern. Although cyclophosphamide-based regimens have been partly replaced by newer agents in both ANCA-associated vasculitis and lupus nephritis (namely rituximab or mycophenolate, respectively) their short-term and medium-term adverse events may not be significantly less frequent and we can only hope that new treatments will translate into better long-term outcomes including better long-term safety. Read More

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http://dx.doi.org/10.1159/000368569DOI Listing
July 2015
10 Reads

Relationship between HSP70-2 A+1267G Polymorphism and Cardiovascular Events of Chinese Peritoneal Dialysis Patients.

Nephron Clin Pract 2014 20;128(1-2):153-8. Epub 2014 Nov 20.

Carol and Richard Yu Peritoneal Dialysis Research Centre, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, SAR, China.

Background: Heat shock proteins (HSPs) are expressed by cells in response to various environmental stresses. A single-nucleotide polymorphism A+1267G of the HSPA1B gene affects the expression of HSP70-2, with the A allele being protective against inflammatory conditions. We investigated the relation between the HSP A+1267G polymorphism and the clinical outcomes of Chinese peritoneal dialysis (PD) patients. Read More

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http://dx.doi.org/10.1159/000368237DOI Listing
July 2015
26 Reads

Population-based estimated reference creatinine values: a novel method of a robust electronic acute kidney injury alert system.

Nephron Clin Pract 2014 19;128(1-2):166-70. Epub 2014 Nov 19.

Clinical Chemistry, Royal Liverpool University Hospital, Liverpool, UK.

Background: Acute kidney injury (AKI) is common in hospitalized patients. Despite the progress that has been made in the last decade, early identification of AKI cases remains a challenge. In recent years, electronic AKI alert (e-AKI alert) systems have been tested and are usually based on changes in serum creatinine (Cr) values. Read More

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http://dx.doi.org/10.1159/000368236DOI Listing
July 2015
15 Reads

Fibroblast growth factor 23/klotho axis in chronic kidney disease.

Nephron Clin Pract 2014 8;128(1-2):1-10. Epub 2014 Nov 8.

Kidney Center, Department of Medicine, Tokyo Women's Medical University, Tokyo, Japan.

Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate and 1,25-hydroxyvitamin D [1,25(OH)2D] metabolism. FGF23 binds to FGF receptor 1 with its coreceptor Klotho and maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In addition, FGF23 reduces the synthesis and accelerates the degradation of 1,25(OH)2D to reduce intestinal phosphate absorption. Read More

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http://dx.doi.org/10.1159/000365787DOI Listing
July 2015
7 Reads

Comparison of different methods of erythrocyte dysmorphism analysis to determine the origin of hematuria.

Nephron Clin Pract 2014 8;128(1-2):88-94. Epub 2014 Nov 8.

Division of Nephrology, Department of Internal Medicine, Botucatu Medical School, Universidade Estadual Paulista, Botucatu, Brazil.

Background/aims: There is disagreement regarding the performance of conventional optical microscopy to assess the origin of hematuria. The aim of this study was to determine the optimal cutoff point for dysmorphic cells in order to detect glomerular hematuria by optical and phase-contrast microscopy.

Methods: In total, 131 urine samples (66 from patients with glomerulopathies and 65 from nephrolithiasis patients) were evaluated in a blinded fashion. Read More

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https://www.karger.com/Article/FullText/367848
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http://dx.doi.org/10.1159/000367848DOI Listing
July 2015
11 Reads

Agreement of single- and multi-frequency bioimpedance measurements in hemodialysis patients: an ancillary study of the Frequent Hemodialysis Network Daily Trial.

Nephron Clin Pract 2014 7;128(1-2):115-26. Epub 2014 Nov 7.

Research Division, Renal Research Institute, New York, N.Y., USA.

Background: Bioimpedance analysis (BIA) is well established to assess body composition. Agreements between single- and multi-frequency bioimpedance (SF-BIA, MF-BIS) measurements in subjects undergoing 6 or 3 times/week hemodialysis (HD) were analyzed.

Methods: Total body water (TBW) and intra- and extracellular fluid (ICF, ECF) of subjects enrolled in the Frequent Hemodialysis Network (FHN) Daily Trial (www. Read More

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http://dx.doi.org/10.1159/000366447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420240PMC
July 2015
16 Reads

Gabriel Richet (1916-2014), founding editor of Nephron.

Authors:
Leon G Fine

Nephron Clin Pract 2014 6;128(3-4):414-5. Epub 2014 Nov 6.

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http://dx.doi.org/10.1159/000369146DOI Listing
July 2015
7 Reads

Periodontal disease, renal dysfunction and heightened leukocytosis.

Nephron Clin Pract 2014 8;128(1-2):107-14. Epub 2014 Nov 8.

Department of Epidemiology and Public Health-Gerontology, University of Maryland School of Medicine, Baltimore, Md., USA.

Background: Leukocytosis is a powerful predictor of incident chronic kidney disease (CKD) and related outcomes. However, the association between periodontitis measures and increased leukocytosis in the context of CKD has not been well described. We sought to identify which individual measures of periodontal disease may best associate with reduced estimated glomerular filtration rate (eGFR) and albuminuria, and to test if these measures were associated with increased leukocytosis in subjects with established CKD. Read More

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http://dx.doi.org/10.1159/000366445DOI Listing
July 2015
5 Reads

New biologics for glomerular disease on the horizon.

Nephron Clin Pract 2014 7;128(3-4):283-91. Epub 2014 Nov 7.

Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.

The major advances achieved in immunology and cellular biology have led to the development of biotherapies that specifically target different mediators and pathways involved in the physiopathology of renal diseases. After the major breakthroughs obtained with B-cell depletion in autoantibody-mediated glomerulopathies, several other immunomodulation strategies are being tested in autoimmune glomerulonephritides, such as blockade of B-cell costimulation and activation, inhibition of complement pathways or modification of the T-B-lymphocyte crosstalk. Other drugs, inhibiting proinflammatory cytokines, are being developed in order to control the inflammatory response initiating and amplifying the kidney tissue injury observed in different systemic diseases. Read More

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http://dx.doi.org/10.1159/000368593DOI Listing
July 2015
7 Reads

Eculizumab in the treatment of membranoproliferative glomerulonephritis.

Authors:
Andrew S Bomback

Nephron Clin Pract 2014 11;128(3-4):270-6. Epub 2014 Nov 11.

Department of Medicine, Division of Nephrology, Columbia University Medical Center, New York, N.Y., USA.

A major shift in our understanding of the membranoproliferative glomerulonephritis (MPGN) lesion is the focus on which components of the complement pathway are involved in mediating renal injury. Hence, MPGN is no longer classified solely by ultrastructural findings on biopsy but instead divided into immune complex-mediated lesions versus complement-mediated lesions. This emphasis on complement, in turn, leads to interest in therapies that target complement as potential disease-modifying agents. Read More

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http://dx.doi.org/10.1159/000368592DOI Listing
July 2015
6 Reads

Rituximab in adult minimal change disease and focal segmental glomerulosclerosis.

Nephron Clin Pract 2014 8;128(3-4):277-82. Epub 2014 Nov 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, Innsbruck, Austria.

Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing immunosuppressive agents with potential toxic side effects also restricts their long-term use. Rituximab, a monoclonal antibody targeting CD20, has been increasingly used in the therapy of difficult-to-treat nephrotic syndrome. Read More

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http://dx.doi.org/10.1159/000368590DOI Listing
July 2015
5 Reads

Anti-phospholipase A2 receptor antibodies and the pathogenesis of membranous nephropathy.

Nephron Clin Pract 2014 11;128(3-4):232-7. Epub 2014 Nov 11.

Sorbonne Universités, UPMC Univ Paris 06, UMR-S 1155, Paris, France.

Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, the type-M phospholipase A2 receptor (PLA2R), and cationic bovine serum albumin as target antigens of circulating and deposited antibodies in neonatal alloimmune, adult 'idiopathic', and early childhood MN, respectively. A genome-wide association study further showed a highly significant association of the PLA2R1 and the HLA-DQA1 loci with idiopathic MN in patients of white ancestry. Read More

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http://dx.doi.org/10.1159/000368588DOI Listing
July 2015
9 Reads

Circulating endotoxaemia and frequent haemodialysis schedules.

Nephron Clin Pract 2014 12;128(1-2):141-6. Epub 2014 Nov 12.

Department of Renal Medicine, Royal Derby Hospital, Derby, UK.

Background/aims: Endotoxaemia, a driver of systemic inflammation, appears to be driven by dialysis-induced circulatory stress in haemodialysis (HD) patients. More frequent HD regimens are associated with lower ultrafiltration requirements, improved haemodynamic stability and lower systemic inflammation. This study investigated the hypothesis that more frequently dialysed patients, with reduced exposure to dialysis-induced haemodynamic perturbation, would have lower circulating endotoxin (ET) levels. Read More

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http://dx.doi.org/10.1159/000366519DOI Listing
July 2015
10 Reads

Biologic therapy in lupus nephritis.

Nephron Clin Pract 2014 11;128(3-4):255-60. Epub 2014 Nov 11.

Department of Rheumatology, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Bruxelles, Belgique.

This position paper critically analyzes the available controlled data regarding biologic therapy in lupus nephritis (LN). Rather than an exhaustive review of all published evidence, the stress is put on the unmet medical needs in LN, the design of trials aimed at testing the effect of a biologic in LN, the possible reasons for LN trial failures and the future of biological therapy in LN. Read More

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http://dx.doi.org/10.1159/000368587DOI Listing
July 2015
4 Reads

Lupus nephritis: from pathogenesis to targets for biologic treatment.

Nephron Clin Pract 2014 8;128(3-4):224-31. Epub 2014 Nov 8.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität, München, Munich, Germany.

Background/aims: Lupus nephritis is an organ manifestation of systemic autoimmunity. Current treatment algorithms are still based on unselective immunosuppressive drugs. There is hope that highly selective biological drugs could be as or even more effective but less toxic. Read More

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http://dx.doi.org/10.1159/000368581DOI Listing
July 2015
29 Reads

Rituximab in the treatment of anti-neutrophil cytoplasm antibody-associated vasculitis.

Authors:
Rachel B Jones

Nephron Clin Pract 2014 14;128(3-4):243-9. Epub 2014 Nov 14.

Department of Renal Medicine, Addenbrooke's Hospital Cambridge, Cambridge, UK.

The introduction of cyclophosphamide and high-dose glucocorticoids for anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) has allowed a reduction in 1-year mortality from 80% to 10-20%. AAV is now a chronic disease, and greater emphasis has turned to improving treatment-related toxicity, reducing relapses and providing alternative treatments for refractory disease. Rituximab, an anti-CD20 B cell-depleting therapy, has been used for over a decade in patients with AAV. Read More

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http://dx.doi.org/10.1159/000368580DOI Listing
July 2015
6 Reads

Pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis and potential targets for biologic treatment.

Nephron Clin Pract 2014 11;128(3-4):216-23. Epub 2014 Nov 11.

Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV) are autoimmune diseases in which the small vessels are inflamed. Clinical observations suggest a pathogenic role for ANCA. Such a role is supported by in vitro experimental data and animal models, particularly for myeloperoxidase-ANCA. Read More

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http://dx.doi.org/10.1159/000368570DOI Listing
July 2015
5 Reads

JTT-751 for treatment of patients with hyperphosphatemia on peritoneal dialysis.

Nephron Clin Pract 2014 11;128(1-2):135-40. Epub 2014 Nov 11.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Background/aims: JTT-751 (ferric citrate hydrate) is a novel iron-based phosphate approved in Japan for the treatment of hyperphosphatemia in dialysis and nondialysis patients with chronic kidney disease.

Methods: In this phase 3, multicenter, open-label, dose-adjusted study, we investigated the efficacy and safety of JTT-751 in peritoneal dialysis patients. A total of 56 patients with serum phosphate ≥5. Read More

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http://dx.doi.org/10.1159/000366482DOI Listing
July 2015
13 Reads

Efficacy of oral hydration in the prevention of contrast-induced acute kidney injury in patients undergoing coronary angiography or intervention.

Nephron Clin Pract 2014 4;128(1-2):95-100. Epub 2014 Nov 4.

Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey.

Background: Efficacy of intravenous (IV) volume expansion in preventing contrast-induced acute kidney injury (CI-AKI) is well known. However, the role of oral hydration has not been well established. The aim of this work was to evaluate the efficacy of oral hydration in preventing CI-AKI. Read More

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http://dx.doi.org/10.1159/000365090DOI Listing
July 2015
45 Reads

Association of serum bicarbonate with bone fractures in hemodialysis patients: the mineral and bone disorder outcomes study for Japanese CKD stage 5D patients (MBD-5D).

Nephron Clin Pract 2014 4;128(1-2):79-87. Epub 2014 Nov 4.

Blood Purification Unit, Hamamatsu University Hospital, Hamamatsu, Japan.

Background/aims: Bone fracture is often complicated in hemodialysis (HD) patients. Metabolic acidosis is related to bone disease and muscle wasting, but it is not known whether acid-base disturbance is associated with the risk of bone fractures. The aim of this study was to clarify the association of serum bicarbonate level with bone fracture in HD patients. Read More

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http://dx.doi.org/10.1159/000365089DOI Listing
July 2015
7 Reads

Geriatric assessment for therapeutic decision-making regarding renal replacement in elderly patients with advanced chronic kidney disease.

Nephron Clin Pract 2014 4;128(1-2):73-8. Epub 2014 Nov 4.

Division of Nephrology, Hospital Severo Ochoa, Leganes/Madrid, Spain.

Unlabelled: In patients older than 75 years with advanced chronic kidney disease (CKD), the decision between treatment with dialysis [intention to treat with dialysis (ITD)] or conservative care (CC) is a challenge. Geriatric assessment can be helpful. The aim was to identify which factors had had an influence on decision-making. Read More

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http://dx.doi.org/10.1159/000363624DOI Listing
July 2015
18 Reads

Longitudinal assessments of erythropoietin-stimulating agent responsiveness and the association with specific clinical outcomes in dialysis patients.

Nephron Clin Pract 2014 6;128(1-2):147-52. Epub 2014 Nov 6.

Division of Nephrology, Department of Medicine, University Hospital Würzburg, Würzburg, Germany.

Background: Dose requirements of erythropoietin-stimulating agents (ESAs) can vary considerably over time and may be associated with cardiovascular outcomes. We aimed to longitudinally assess ESA responsiveness over time and to investigate its association with specific clinical end points in a time-dependent approach.

Methods: The German Diabetes and Dialysis study (4D study) included 1,255 diabetic dialysis patients, of whom 1,161 were receiving ESA treatment. Read More

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http://dx.doi.org/10.1159/000367975DOI Listing
July 2015
7 Reads

Clinical and biological determinants of sclerostin plasma concentration in hemodialysis patients.

Nephron Clin Pract 2014 4;128(1-2):127-34. Epub 2014 Nov 4.

Nephrology-Dialysis-Transplantation, University of Liège, CHU Sart Tilman, Liège, Belgium.

Background: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years.

Methods: 164 HD patients were included in this observational study. Read More

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http://dx.doi.org/10.1159/000366449DOI Listing
July 2015
19 Reads

Treatment with haemodiafiltration stabilises vascular stiffness (measured by aortic pulse wave velocity) compared to haemodialysis.

Nephron Clin Pract 2014 6;128(1-2):185-91. Epub 2014 Nov 6.

Centre for Nephrology, Royal Free Hospital, University College London Medical School, London, UK.

Background/aims: Cerebrovascular diseases such as stroke are increased in dialysis patients, and haemodiafiltration has been reported to reduce cerebrovascular mortality compared to haemodialysis. We wished to determine whether haemodiafiltration improves arterial stiffness.

Methods: We audited aortic pulse wave velocity (PWV) measurements 6 months apart in 3 cohorts of patients: 69 treated with haemodialysis, 78 who converted from haemodialysis to haemodiafiltration and 142 treated with haemodiafiltration. Read More

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http://dx.doi.org/10.1159/000368242DOI Listing
July 2015
9 Reads

Platelet-derived growth factor receptor-β expression in human peritoneum.

Nephron Clin Pract 2014 6;128(1-2):178-84. Epub 2014 Nov 6.

Division of Nephrology, University Hospital, University of Zurich, Zurich, Switzerland.

Introduction: Simple peritoneal fibrosis and encapsulating peritoneal sclerosis (EPS) are important lesions in the peritoneum of patients on peritoneal dialysis (PD). We have previously described a population of podoplanin-positive myofibroblasts in peritoneal biopsies from patients with EPS. Platelet-derived growth factor receptor-β (PDGFRβ) is a marker of pericytes, and PDGFs might be involved in the fibrotic response of the peritoneum. Read More

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http://dx.doi.org/10.1159/000368241DOI Listing
July 2015
11 Reads

David N.S. Kerr (1927-2014).

Authors:
John Feehally

Nephron Clin Pract 2014 4;128(1-2):201-2. Epub 2014 Nov 4.

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http://dx.doi.org/10.1159/000365980DOI Listing
July 2015
5 Reads

Effect of nocturnal haemodialysis on body composition.

Nephron Clin Pract 2014 6;128(1-2):171-7. Epub 2014 Nov 6.

Dialysis Center Groningen, Groningen, The Netherlands.

Background: Haemodialysis patients have a high risk of malnutrition which is associated with increased mortality. Nocturnal haemodialysis (NHD) is associated with a significant increase in protein intake compared with conventional haemodialysis (CHD). It is unclear whether this leads to improved nutritional status. Read More

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http://dx.doi.org/10.1159/000368239DOI Listing
July 2015
7 Reads