90,504 results match your criteria Nephron Clinical Practice[Journal]


The potential for improving cardio-renal outcomes by sodium-glucose co-transporter-2 inhibition in people with chronic kidney disease: a rationale for the EMPA-KIDNEY study.

Clin Kidney J 2018 Dec 25;11(6):749-761. Epub 2018 Oct 25.

Würzburg University Clinic, Würzburg, Germany.

Diabetes is a common cause of chronic kidney disease (CKD), but in aggregate, non-diabetic diseases account for a higher proportion of cases of CKD than diabetes in many parts of the world. Inhibition of the renin-angiotensin system reduces the risk of kidney disease progression and treatments that lower blood pressure (BP) or low-density lipoprotein cholesterol reduce cardiovascular (CV) risk in this population. Nevertheless, despite such interventions, considerable risks for kidney and CV complications remain. Read More

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December 2018

Induction of steady-state glomeruloid sphere by self-assembly from human embryonic kidney cells.

Biochem Biophys Res Commun 2018 Dec 3. Epub 2018 Dec 3.

Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

The glomerulus is a network of capillaries known as a tuft, located at the beginning of a nephron in the kidney. Here we describe a novel method for the induction of a macroscopically visible three-dimensional glomerulus-like sphere (GLS). This procedure did not require any additional cytokines and completed the formation of spheres within 24 h. Read More

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December 2018

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis.

Nephron 2018 Dec 12:1-11. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Background/aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury.

Methods: To test that idea, we collected urine samples from 37 patients with glomerular disease; purified the urinary EVs; characterized them using Nanosight, western blotting, and immunoelectron microscopy; and determined FSP1 and soluble CD163 levels using enzyme-linked immunosorbent assays. Read More

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December 2018

The Effect of Modified Biolasol Solution on the Efficacy of Storing Isolated Porcine Kidneys.

Biomed Res Int 2018 12;2018:7465435. Epub 2018 Nov 12.

"Biochefa" Pharmaceutical Research and Production Plant, Sosnowiec, Poland.

Biolasol is a newly developed solution for storing the liver, pancreas, kidneys, and heart by simple hypothermia. It exhibits high efficacy in maintaining structural and functional integrity of the graft prior to its transplantation. The solution was modified by the addition of ascorbic acid (0. Read More

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November 2018

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis.

Int J Dent 2018 13;2018:9610892. Epub 2018 Nov 13.

Unit of Periodontology and Dental Hygiene, School of Dental Sciences, Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.

Chronic renal failure is a progressive disease characterized by a gradual destruction of nephrons and a consequent reduction of kidney function. End-stage renal disease (ESRD) necessitates renal replacement therapy as peritoneal dialysis, hemodialysis, or transplantation. Patients affected by ESRD or in hemodialysis are at risk for developing a number of comorbidities including hypertension, anemia, risk of bleeding, susceptibility to infection, medication side effects, and oral manifestations associated with the disease itself and with hemodialysis treatment. Read More

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November 2018

Nephron Sparing Surgery for Synchronous Bilateral Wilms-Operative Steps.

Indian J Surg Oncol 2018 Dec 20;9(4):601-604. Epub 2018 Jul 20.

Department of Urology, JN Medical College, KLE Academy of Higher Education & Research (Deemed-to-be-University) JNMC Campus, Belagavi, Karnataka 590010 India.

Approximately 5% of children with Wilms tumor present with bilateral disease. The treatment challenge is to achieve a high cure rate while maintaining adequate long-term renal function. We report the feasibility and outcome of nephron sparing surgery in a child with bilateral Wilms tumor who was treated at our institution. Read More

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December 2018

Substrates and inhibitors of phosphate transporters: from experimental tools to pathophysiological relevance.

Pflugers Arch 2018 Dec 7. Epub 2018 Dec 7.

Department of Toxicology, Veterinary Faculty, University of Zaragoza, Calle Miguel Servet, 177, E50013, Zaragoza, Spain.

The control of inorganic phosphate homeostasis is mediated through the activity of sodium-coupled Pi transporters located in the intestine, kidneys, and bone. To study these transporters in either the native tissue or after heterologous expression, it is very important to use specific inhibitors of the studied transporter, in order to know the corresponding relevance in the total Pi uptake and to differentiate from the activity of other transporters. Inhibitors are also necessary as drugs for treating Pi homeostasis disorders. Read More

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December 2018

Trends in the treatment of clinical T1 renal cell carcinoma for octogenarians: Analysis of the National Cancer Database.

J Geriatr Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO, United States. Electronic address:

Objective: Treatment of renal cell carcinoma has evolved with emphasis on nephron preservation for small renal masses. Our objective was to evaluate the proportions of treatment types for octogenarians with clinical stage 1 renal cell carcinoma.

Materials And Methods: The National Cancer Database was analyzed from 2004 to 2015. Read More

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December 2018

Evolution of Robot-assisted Partial Nephrectomy: Techniques and Outcomes from the Transatlantic Robotic Nephron-sparing Surgery Study Group.

Eur Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Onze-Lieve-Vrouw Hospital, Aalst, Belgium; ORSI Academy, Melle, Belgium.

Background: Robot-assisted partial nephrectomy (RAPN) is considered a feasible minimally invasive alternative to open partial nephrectomy (OPN) for the surgical treatment of renal tumors.

Objective: To provide further evidence supporting the effectiveness of RAPN in a contemporary patient population treated at one of three tertiary care centers for robotic surgery and to describe the evolution of RAPN-based technical improvements.

Design, Setting, And Participants: The Transatlantic Robotic Nephron-sparing Surgery (TRoNeS) study group prospectively collected data from 635 patients subjected to RAPN for clinically localized kidney cancer between 2010 and 2016 at three high-volume tertiary care centers. Read More

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December 2018
1 Read

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

J Am Soc Nephrol 2018 Dec 5. Epub 2018 Dec 5.

III. Department of Medicine,

Background: Nephron number is a major determinant of long-term renal function and cardiovascular risk. Observational studies suggest that maternal nutritional and metabolic factors during gestation contribute to the high variability of nephron endowment. However, the underlying molecular mechanisms have been unclear. Read More

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December 2018
1 Read

Polycystosis of the renal sinus or polycystic kidney disease Controversies, challenges and history of a shared discovery.

Actas Urol Esp 2018 Dec 6;42(10):645-648. Epub 2018 Jul 6.

Servicio de Urología, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Madrid, España.

Objective: To recall the history of the discovery of non-nephron cystic disease, detected simultaneously in 2 hospitals in Madrid, and the vicissitudes that the authors endured during the process of recognising this disease, while being ignored by the international scientific literature.

Material And Method: We analysed the authors' first publications and presentations, their correspondence relaying the difficulties in reporting the confusion with adult polycystic kidney disease (APKD) and the subsequent nosological identification of the process. We consulted with individuals who worked with the 2 authors to increase the accuracy and objectivity of the history report. Read More

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December 2018

Volume and function of the operated kidney after nephron-sparing surgery for unilateral renal tumor.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Pediatric Surgery Unit, Sapienza University of Rome, Rome, Italy. Electronic address:

Aim: We sought to assess the magnitude of functional decline and the natural history of the operated kidney residual function after zero-ischemia nephron-sparing surgery (Z-NSS) in children with unilateral renal tumor (URT).

Patients And Methods: 50 children were treated for URT at our surgical unit between 1992 and 2016. Of these 12 who underwent Z-NSS were available for the current analysis. Read More

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November 2018
1 Read

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling.

Cell Rep 2018 Dec;25(10):2668-2675.e3

Division of Nephrology and Hypertension, Oregon Health & Science University, Portland, OR 97239, USA; Fondation LeDucq Transatlantic Networks of Excellence, Paris 75116, France; Renal Section, Veterans Affairs Portland Health Care System, Portland, OR 97239, USA.

Distal nephron remodeling contributes to the pathophysiology of many clinically relevant scenarios, including diuretic resistance and certain Mendelian disorders of blood pressure. However, constitutive genetic disruptions are likely to have substantial developmental effects in this segment, and whether tubule remodeling upon physiological stimuli is a normal homeostatic mechanism is not known. Since the distal nephron acts as a potassium sensor, we assessed proliferation and tubule length in three dimensions upon dietary or inducible genetic manipulation by using optical clearing of adult mouse kidneys, whole-mount immunolabeling, and advanced light microscopy. Read More

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December 2018
1 Read

Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014.

JAMA Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Stanford University Medical Center, Stanford, California.

Importance: Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx).

Objective: To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence. Read More

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December 2018
2 Reads

CHANGES OF PROTEINURIA AND ACID-REGULATING KIDNEY FUNCTION IN MATURE RATS WITH SLOW AND RAPID ACETYLATION TYPE UNDER CONDITIONS OF SUBACUTE CADMIUM-NITRATE INTOXICATION.

Georgian Med News 2018 Oct(283):133-137

Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi, Ukraine.

The experiments conducted on non-linear mature laboratory albino rats determined that under conditions of subacute cadmium-nitrate intoxication the indices of proteinuria and acid-regulating renal function depend on acetylation phenotype. Unlike rapid acetylators considerable increase of protein concentration in urine (192,8%, р<0,05) and standardized by glomerular filtration protein excretion (141,7%, р<0,05) are indicative of higher susceptibility of rats with slow acetylation type to nephrotoxic action of cadmium chloride and sodium nitrate. Lack of protein loss with urine and adaptive-compensative character of acid-regulating renal function changes directed to elimination of hydrogen ions excess from the body give evidence concerning less intensive damage of the nephron tubular portion in rats with rapid acetylation type, and at the same time do not exclude development of nephropathy. Read More

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October 2018
1 Read

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.

Elife 2018 12 5;7. Epub 2018 Dec 5.

Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, United States.

A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell organization and interactions within the nephrogenic niche, ultimately determining nephron endowment. In mutants, nephron progenitors dispersed from their restricted niche, intermixing with interstitial progenitors. Read More

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December 2018
3 Reads

Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis.

J Am Soc Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Pediatrics and Rare Diseases Group and

Background: Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdifferentiation (which could explain acquired diabetes insipidus in patients receiving lithium) is unclear.

Methods: To investigate whether loss of Notch signaling can trigger principal cells to lose their identity, we genetically inactivated and , inactivated the Notch signaling target , or induced expression of a Notch signaling inhibitor in all of the nephron segments and collecting ducts in mice after kidney development. Read More

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December 2018
1 Read

Factors Influencing Cyst Infection in Autosomal Dominant Polycystic Kidney Disease.

Nephron 2018 Dec 4:1-12. Epub 2018 Dec 4.

Department of Nephrology, Toranomon Hospital, Tokyo, Japan.

Background: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death due to cyst infection. Read More

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December 2018
6 Reads

The Influence of Donor to Recipient Size Matching on Kidney Transplant Outcomes.

Transplant Direct 2018 Oct 7;4(10):e391. Epub 2018 Sep 7.

Department of Nephrology and Transplantation, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.

Background: Nephron endowment in renal transplantation is infrequently considered, but may have important implications for post kidney transplantation outcomes. In this population-cohort study, we analyzed the deceased-donor kidney transplant outcomes stratified by donor-to-recipient size ratios.

Methods: Data for all deceased-donor adult kidney transplantation recipients between 2003 and 2015 were extracted from the UK Transplant Registry. Read More

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October 2018
2 Reads

Spontaneous calcium activity in metanephric mesenchymal cells regulates branching morphogenesis in the embryonic kidney.

FASEB J 2018 Nov 29:fj201802054R. Epub 2018 Nov 29.

Department of Applied Physics, Science for Life Laboratory, Kungliga Tekniska Högskolan (KTH) Royal Institute of Technology, Solna, Sweden.

The central role of calcium signaling during development of early vertebrates is well documented, but little is known about its role in mammalian embryogenesis. We have used immunofluorescence and time-lapse calcium imaging of cultured explanted embryonic rat kidneys to study the role of calcium signaling for branching morphogenesis. In mesenchymal cells, we recorded spontaneous calcium activity that was characterized by irregular calcium transients. Read More

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November 2018
1 Read

Giant bilateral renal metastases from a meningeal hemangiopericytoma.

J Cancer Res Ther 2018 Oct-Dec;14(6):1434-1436

Urology Unit, Civil Hospital of Guastalla, Guastalla, RE, Italy.

We report the third case of bilateral metastatic renal meningeal hemangiopericytoma (HPC) 16 years after initial intracranial presentation. A 47-year-old male patient presented with abdominal mass drew our attention. Computed tomography (CT) demonstrated bilateral renal masses and another mass caudal to the lower pole of left kidney from which it was separated. Read More

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November 2018
1 Read

Furosemide Reduces BK-αβ4-mediated K+ Secretion in Mice on an Alkaline High K+ Diet.

Am J Physiol Renal Physiol 2018 Nov 28. Epub 2018 Nov 28.

Dept of Cellular and Integrative Physiology, University of Nebraska Medical Center, United States.

Special high K diets have cardio-protective effects and are often warranted in conjunction with diuretics such as furosemide for treating hypertension. However, it is not understood how a high K diet (HK) influences the actions of diuretics on renal K handling. Furosemide acidifies the urine by increasing acid secretion via the Na-H exchanger 3 (NHE3) in TAL and vacuolar H-ATPase (V-ATPase) in the distal nephron. Read More

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November 2018

Patients with hypokalemia develop WNK bodies in the distal convoluted tubule of the kidney.

Am J Physiol Renal Physiol 2018 Nov 28. Epub 2018 Nov 28.

Institut für Vegetative Anatomie, Charité Universitätsmedizin Berlin, Germany.

Hypokalemia contributes to the progression of chronic kidney disease, while a definitive pathophysiogical theory to explain this remains to be established. K deficiency results in profound alterations of renal epithelial transport. These include an increase of salt reabsorption via the Na,Cl-cotransporter (NCC) of the distal convoluted tubule (DCT), which minimizes electroneutral K loss in downstream nephron segments. Read More

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November 2018
1 Read

Regulation of Renal Differentiation by Trophic Factors.

Front Physiol 2018 12;9:1588. Epub 2018 Nov 12.

Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Classically, trophic factors are considered as proteins which support neurons in their growth, survival, and differentiation. However, most neurotrophic factors also have important functions outside of the nervous system. Especially essential renal growth and differentiation regulators are glial cell line-derived neurotrophic factor (GDNF), bone morphogenetic proteins (BMPs), and fibroblast growth factors (FGFs). Read More

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November 2018

Hypokalemia Associated With a Claudin 10 Mutation: A Case Report.

Am J Kidney Dis 2018 Oct 25. Epub 2018 Oct 25.

Division of Nephrology, Department of Pediatrics, NYU Langone Health, New York, NY. Electronic address:

Hypokalemia of renal origin can arise from genetic abnormalities in a variety of transporters or channel proteins that mediate tubular handling of potassium. Recently, mutations in claudin 10 have been documented in patients with hypokalemia in association with a range of other electrolyte abnormalities and skin and sweat gland manifestations. We report a 12-year-old Hispanic boy who presented with anhydrosis, aptyalism, alacrima, hypokalemia, and hypocalciuria, in whom we detected a homozygous mutation in the claudin 10 gene. Read More

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October 2018

controls nephron segmentation during zebrafish embryonic kidney ontogeny.

Elife 2018 11 26;7. Epub 2018 Nov 26.

Department of Biological Sciences, University of Notre Dame, Indiana, United States.

Nephron segmentation involves a concert of genetic and molecular signals that are not fully understood. Through a chemical screen, we discovered that alteration of peroxisome proliferator-activated receptor (PPAR) signaling disrupts nephron segmentation in the zebrafish embryonic kidney (Poureetezadi et al., 2016). Read More

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November 2018

A 2018 overview of diuretic resistance in heart failure.

Rev Port Cardiol 2018 Nov 20;37(11):935-945. Epub 2018 Nov 20.

Unidade de Insuficiência Cardíaca, Serviço de Medicina III, Hospital São Francisco Xavier, Lisbon, Portugal; NOVA Medical School, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.

Heart failure is a disease with high direct and indirect costs. Current treatment includes drugs that alter disease progression and drugs that to improve symptoms. Loop diuretics are the cornerstone of congestion relief for acute management, as well as for chronic stabilization. Read More

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November 2018
1 Read

Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease.

Nephron 2018 Nov 22:1-8. Epub 2018 Nov 22.

Chair of Nephrology, Department of Public Health, University Federico II of Naples, Naples, Italy.

Background And Objectives: Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several studies, its prevalence is at present unknown. Read More

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November 2018
1 Read

Technical Considerations for Nephron-Sparing Surgery in Children: What Is Needed to Preserve Renal Units?

J Surg Res 2018 Dec 9;232:614-620. Epub 2018 Aug 9.

Division of Pediatric Surgery, Department of Surgery, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan.

Background: Chemotherapy is used preoperatively for children with bilateral Wilms tumor (BWT) or unilateral high-risk Wilms tumor (UHRWT) to promote tumor regression to facilitate renal preservation with nephron-sparing surgery (NSS). In adults, various surgical techniques have been described to preserve renal tissue. Few studies have examined the use of surgical adjuncts in NSS in children with renal tumors. Read More

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December 2018
3 Reads

What are the Risk Factors for One-Year Mortality in Older Patients with Chronic Kidney Disease? An Analysis of the Cleveland Clinic CKD Registry.

Nephron 2018 Nov 21:1-7. Epub 2018 Nov 21.

Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.

Background: Prognostic factors after dialysis initiation among older chronic kidney disease (CKD) patients are not well studied. In this study, we examined the risk factors associated with 1-year mortality after dialysis initiation among older CKD patients.

Methods: In this retrospective study, we included 621 CKD patients from an electronic medical record based CKD registry that was linked to the United States Renal Data System data. Read More

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November 2018
10 Reads

Synthesizing Living Tissues with Microfluidics.

Acc Chem Res 2018 Nov 20. Epub 2018 Nov 20.

Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience , National Center for NanoScience and Technology , Beijing 100190 , P. R. China.

In native tissues, various cell types organize and spatiotemporally function and communicate with neighboring or remote cells in a highly regulated way. How can we replicate these amazing functional structures in vitro? From the view of a chemist, the heterogeneous cells and extracellular matrix (ECM) could be regarded as various chemical substrate materials for "synthetic" reactions during tissue engineering. But how can we accelerate these reactions? Microfluidics provides ideal solutions. Read More

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November 2018
4 Reads

The role of osteopontin in kidney diseases.

Authors:
Beata Kaleta

Inflamm Res 2018 Nov 19. Epub 2018 Nov 19.

Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 59 Nowogrodzka St., 02-006, Warsaw, Poland.

Background: Osteopontin (OPN) is a pleiotropic glycoprotein expressed in various cell types in animals and in humans, including bone, immune, smooth muscle, epithelial and endothelial cells. Moreover, OPN is found in kidneys (in the thick ascending limbs of the loop of Henle and in distal nephrons) and urine. The protein plays an important role in mineralization and bone resorption. Read More

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November 2018
6 Reads

The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.

Cell Physiol Biochem 2018 19;51(1):393-410. Epub 2018 Nov 19.

Mossakowski Medical Research Centre Polish Academy of Sciences, Laboratory of Molecular and Cellular Nephrology, Gdańsk,

Background/aims: Podocytes are dynamic polarized cells on the surface of glomerular capillaries that are an essential part of the glomerular filtration barrier. AMP-activated protein kinase (AMPK), a key regulator of glucose and fatty acid metabolism, plays a major role in obesity and type 2 diabetes. Accumulating evidence suggests that TRPC6 channels are crucial mediators of calcium transport in podocytes and are involved in regulating glomerular filtration. Read More

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December 2018
10 Reads

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney.

J Vis Exp 2018 Nov 1(141). Epub 2018 Nov 1.

Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh;

Preservation of glomerular structure and function is pivotal in the prevention of glomerulonephritis, a category of kidney disease characterized by proteinuria which can eventually lead to chronic and end-stage renal disease. The glomerulus is a complex apparatus responsible for the filtration of plasma from the body. In disease, structural integrity is lost and allows for the abnormal leakage of plasma contents into the urine. Read More

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November 2018
3 Reads

Available ablation energies to treat cT1 renal cell cancer: emerging technologies.

World J Urol 2018 Nov 17. Epub 2018 Nov 17.

Department of Radiology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Purpose: An increasing interest in percutaneous ablation of renal tumors has been caused by the increasing incidence of SRMs, the trend toward minimally invasive nephron-sparing treatments and the rapid development of local ablative technologies. In the era of shared decision making, patient preference for non-invasive treatments also leads to an increasing demand for image-guided ablation. Although some guidelines still reserve ablation for poor surgical candidates, indications may soon expand as evidence for the use of the two most validated local ablative techniques, cryoablation (CA) and radiofrequency ablation (RFA), is accumulating. Read More

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November 2018
1 Read

Optimized Calcium Supplementation Approach for Regional Citrate Anticoagulation.

Nephron 2018 Nov 16:1-9. Epub 2018 Nov 16.

Division of Nephrology and Critical Care Nephrology Unit, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai,

Background: It has been confirmed that regional citrate anticoagulation (RCA) plays an effective role in extracorporeal anticoagulation. The current trial-and-error calcium supplementation approach, with intensive monitoring of calcium levels, restricts the widespread use of RCA. Therefore, this study aimed to optimize the calcium supplementation approach for RCA. Read More

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November 2018
4 Reads

Weighted Gene Correlation Network Analysis (WGCNA) Detected Loss of MAGI2 Promotes Chronic Kidney Disease (CKD) by Podocyte Damage.

Cell Physiol Biochem 2018 16;51(1):244-261. Epub 2018 Nov 16.

Department of Nephrology, Lianshui County People's Hospital, Huai'an City,

Background/aims: Podocyte damage is associated with proteinuria, glomerulosclerosis and decline of renal function. This study aimed to screen critical genes associated with podocyte injury in chronic kidney disease (CKD) by weighted gene correlation network analysis (WGCNA), and explore related functions.

Methods: GSE66107, GSE93798, GSE30528, GSE32591 gene expression data including podocyte injury models or glomeruli in CKD patients were downloaded from the GEO database. Read More

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December 2018
3 Reads

The atypical chemokine receptor 2 limits progressive fibrosis after acute ischemic kidney injury.

Am J Pathol 2018 Nov 15. Epub 2018 Nov 15.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

Following renal ischemia-reperfusion injury (IRI) resolution of inflammation allows tubular regeneration, whereas ongoing inflammatory injury mediated by infiltrating leukocytes leads to nephron loss and renal fibrosis, typical hallmarks of chronic kidney disease. The atypical chemokine receptor 2 (ACKR2) is a chemokine decoy receptor, that binds and scavenges inflammatory CC-chemokines and reduces local leukocyte accumulation. We hypothesized that ACKR2 limits leukocyte infiltration, inflammation, and fibrotic tissue remodeling after renal IRI, thus preventing progression to chronic kidney disease. Read More

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November 2018
6 Reads

Use of delayed intervention for small renal masses initially managed with active surveillance.

Urol Oncol 2019 Jan 13;37(1):18-25. Epub 2018 Nov 13.

Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD.

Introduction: A number of patients who elect active surveillance of their small renal masses (≤4 cm) subsequently pursue delayed intervention (DI). The indications, timing, and rates of DI have not been well determined prospectively.

Materials And Methods: Data from Delayed Intervention and Surveillance for Small Renal Masses, a prospective, multi-institutional registry was utilized to evaluate factors associated with DI between 2009 and 2018. Read More

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January 2019
4 Reads

Automated safety event monitoring using electronic medical records in a clinical trial setting: Validation study using the VA NEPHRON-D trial.

Clin Trials 2018 Nov 16:1740774518813121. Epub 2018 Nov 16.

1 Cooperative Studies Program Coordinating Center (CSPCC), VA Connecticut Healthcare System, West Haven, CT, USA.

Background/aims:: Electronic medical records are now frequently used for capturing patient-level data in clinical trials. Within the Veterans Affairs health care system, electronic medical record data have been widely used in clinical trials to assess eligibility, facilitate referrals for recruitment, and conduct follow-up and safety monitoring. Despite the potential for increased efficiency in using electronic medical records to capture safety data via a centralized algorithm, it is important to evaluate the integrity and accuracy of electronic medical record-captured data. Read More

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November 2018
2 Reads

Oncologic outcomes of nephron-sparing surgery in patients with T1 multifocal renal cell carcinoma.

Clin Transl Oncol 2018 Nov 15. Epub 2018 Nov 15.

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin, 300211, China.

Objective: This study is performed to explore the pathological characteristics and oncologic outcomes of T1 multifocal renal cell carcinoma (RCC).

Methods: The clinical data of 600 patients (442 males and 158 females) between the age of 29 and 73 years, diagnosed with T1 RCC were collected from three hospitals in China, out of which 421 cases had undergone nephron-sparing surgery (NSS) and 179 cases had undergone radical nephrectomy (RN) between December 2010 and January 2015.

Results: Tumor was identified with multifocality in 32 patients (5. Read More

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November 2018
5 Reads

Changes in cell fate determine the regenerative and functional capacity of the developing kidney before and after release of obstruction.

Clin Sci (Lond) 2018 Dec 5;132(23):2519-2545. Epub 2018 Dec 5.

Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, U.S.A.

Congenital obstructive nephropathy is a major cause of chronic kidney disease (CKD) in children. The contribution of changes in the identity of renal cells to the pathology of obstructive nephropathy is poorly understood. Using a partial unilateral ureteral obstruction (pUUO) model in genetically modified neonatal mice, we traced the fate of cells derived from the renal stroma, cap mesenchyme, ureteric bud (UB) epithelium, and podocytes using , and mice respectively, crossed with double fluorescent reporter (membrane-targetted tandem dimer Tomato (mT)/membrane-targetted GFP (mG)) mice. Read More

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December 2018
4 Reads

Long-Term Administration of Angiotensin (1-7) to Mice Reduces Oxidative Stress Damage in the Kidneys and Prevents Renal Dysfunction.

Oxid Med Cell Longev 2018 23;2018:1841046. Epub 2018 Oct 23.

School of Pharmacy, University of Southern California, 1985 Zonal Ave., Los Angeles, CA 90033, USA.

Aims: The goal of this study was to evaluate the effects of long-term (16 weeks) administration of angiotensin (1-7) [A(1-7)] on kidney function in mice and to identify the protective mechanisms of this therapy.

Methods: mice and heterozygous controls were treated with A(1-7) or vehicle daily, subcutaneously for up to 16 weeks. Kidney injury was assessed by measuring blood flow in renal arteries, plasma creatinine levels, and proteinuria. Read More

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December 2018
3 Reads

Icodextrin is Associated with a Lower Risk of Stroke in Peritoneal Dialysis Patients.

Nephron 2018 Nov 13:1-7. Epub 2018 Nov 13.

Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan.

Background/aims: This study investigated whether peritoneal dialysis (PD) patients using icodextrin were at a reduced risk of stroke.

Methods: From Taiwan National Health Insurance data, it was found that there were 6,796 new end-stage renal disease patients undergoing dialysis between 2005 and 2011. We compared the risk of stroke between PD patients with or without icodextrin treatment. Read More

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November 2018
13 Reads

The Clinical Effects of Sildenafil for Erection in Patients after Kidney Transplantation: A Meta-Analysis.

Nephron 2018 Nov 13:1-9. Epub 2018 Nov 13.

Department of Nephrology, The First Hospital of Jilin University, Changchun,

Background: With the wide use of sildenafil in kidney-transplanted patients, it is vital to recognize the effectiveness and safety in clinical practice.

Methods: Full-text articles involving the application of sildenafil after renal transplantation searched out in multiple databases were reviewed. All the meta-analyses were performed with Review Manager 5. Read More

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November 2018
7 Reads

Enhanced expression of the Epithelial Sodium Channel in neutrophils from hypertensive patients.

Biochim Biophys Acta Biomembr 2018 Nov 10;1861(2):387-402. Epub 2018 Nov 10.

Laboratorio de Hematobiología, Escuela Nacional de Medicina y Homeopatía (ENMH), Instituto Politécnico Nacional (I.P.N.), México City, Mexico. Electronic address:

Hypertension (HTN), i.e. abnormally high blood pressure, is a major risk factor for heart attack, stroke, and kidney failure. Read More

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November 2018
6 Reads

Small non-coding RNA expression in mouse nephrogenic mesenchymal progenitors.

Sci Data 2018 Nov 13;5:180218. Epub 2018 Nov 13.

Rangos Research Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

MicroRNAs (miRNAs) are small non-coding RNAs that are essential for the regulation of gene expression and play critical roles in human health and disease. Here we present comprehensive miRNA profiling data for mouse nephrogenic mesenchymal progenitors, a population of cells enriched for nephron progenitors that give rise to most cell-types of the nephron, the functional unit of the kidney. We describe a miRNA expression in nephrogenic mesenchymal progenitors, with 162 miRNAs differentially expressed in progenitors when compared to whole kidney. Read More

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November 2018
7 Reads

Neutrophil Gelatinase-Associated Lipocalin Significantly Correlates with Ischemic Damage in Patients Undergoing Laparoscopic Partial Nephrectomy.

Balkan Med J 2018 Nov 12. Epub 2018 Nov 12.

Department of Anesthesiology, İstanbul University School of Medicine, İstanbul, Turkey.

Background: Laparoscopic partial nephrectomy, minimizing renal function loss due to its nephron sparing nature, has become a standard technique among many experienced centers worldwide in the surgical treatment of localized kidney tumors. Although partial nephrectomy will remain the gold standard, we need to improve perioperative management and surgical method to prevent postoperative acute kidney injury.

Aims: We aimed to demonstrate the frequency of the development of postoperative acute kidney injury following laparoscopic partial nephrectomy in patients with healthy contralateral kidney and the early predictive effects of serum neutrophil gelatinase-associated lipocalin in ischemia reperfusion injury and its association with the warm ischemia time. Read More

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November 2018
4 Reads

Characterization of purinergic receptor expression in ARPKD cystic epithelia.

Purinergic Signal 2018 Nov 11. Epub 2018 Nov 11.

Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.

Polycystic kidney diseases (PKDs) are a group of inherited nephropathies marked by formation of fluid-filled cysts along the nephron. Growing evidence suggests that in the kidney formation of cysts and alteration of cystic electrolyte transport are associated with purinergic signaling. PCK/CrljCrl-Pkhd1pck/CRL (PCK) rat, an established model of autosomal recessive polycystic kidney disease (ARPKD), was used here to test this hypothesis. Read More

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November 2018
2 Reads