129,342 results match your criteria Nephrology nursing journal : journal of the American Nephrology Nurses' Association[Journal]


Correction of pulmonary hypertension with intensive hemodialysis: A case report.

Hemodial Int 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology, University Health Network, Toronto, Canada.

Pulmonary hypertension (PH) defined as a mean pulmonary arterial pressure ≥25 mmHg is a common complication in hemodialysis occurring in up to 58% of patients. PH is classified according to its etiology. We report in a patient with severe PH of mixed etiology (connective tissue disease and left-sided heart failure) who improved after initiation of intensive home hemodialysis. Read More

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http://dx.doi.org/10.1111/hdi.12691DOI Listing
February 2019

Cytomegalovirus and Epstein-Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis.

Pediatr Transplant 2019 Feb 20:e13382. Epub 2019 Feb 20.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.

Background: CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort.

Methods: Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Read More

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http://dx.doi.org/10.1111/petr.13382DOI Listing
February 2019

Association of vaspin rs2236242 gene variants with type 2 diabetes and obesity in a Chinese population: A prospective, single-center study.

J Cell Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Aim: Vaspin is an adipokine separated from visceral fat tissues of obese diabetic rats. This study was to investigate the association between vaspin rs2236242 gene polymorphism and type 2 diabetes mellitus (T2DM) or obesity in a Chinese population.

Materials And Methods: T2DM patients and nondiabetic controls were recruited from Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University (Shanghai, China) from May 1, 2015 to June 30, 2017. Read More

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http://dx.doi.org/10.1002/jcp.28267DOI Listing
February 2019

Evaluation of hemostasis in patients with end-stage renal disease.

PLoS One 2019 20;14(2):e0212237. Epub 2019 Feb 20.

Department of General, Visceral and Transplant Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether bleeding risk can be assessed by global tests of hemostasis. Standard laboratory tests and an extended evaluation of hemostasis by rotational thromboelastometry, platelet function analyzer (PFA) and multiple electrode aggregometry as well as thrombin generation assays and measurement of fibrinolytic potential were performed in 20 patients on hemodialysis, 10 patients on peritoneal dialysis, 10 patients with chronic kidney disease stage G5 (CKD5) and in 10 healthy controls (HC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212237PLOS
February 2019

Significance of subepithelial deposits in patients diagnosed with IgA nephropathy.

PLoS One 2019 20;14(2):e0211812. Epub 2019 Feb 20.

Department of Nephrology, Nagasaki University Hospital, Nagasaki, Japan.

Subepithelial deposits are observed in rare adult IgA nephropathy (IgAN) cases and are a key diagnostic finding in IgA-dominant infection-related glomerulonephritis (IgA-IRGN). Sometimes, it is difficult to distinguish IgA-IRGN from IgAN without a precise clinical history. We hypothesized that some IgA-IRGN cases might be diagnosed as IgAN with subepithelial deposits (IgAN-SD) and aimed to clarify the significance of subepithelial deposits in patients diagnosed with IgAN. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211812PLOS
February 2019

High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.

FASEB J 2019 Feb 20:fj201801921R. Epub 2019 Feb 20.

Division of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.

Oxidative stress contributes substantially to podocyte injury, which plays an important role in the development of diabetic kidney disease. The mechanism of hyperglycemia-induced oxidative stress in podocytes is not fully understood. Glucose-6-phosphate dehydrogenase (G6PD) is critical in maintaining NADPH, which is an important cofactor for the antioxidant system. Read More

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http://dx.doi.org/10.1096/fj.201801921RDOI Listing
February 2019

Ocular dialysis disequilibrium-Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature.

Hemodial Int 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

It has been shown that patients with end-stage renal disease (ESRD) have an increased risk for changes in intraocular pressure during hemodialysis, or ocular dialysis disequilibrium which can cause pain or discomfort during treatment and lead to decreased vision over time. This is a case of an elderly male with ESRD who was having headaches, nausea, and eye pain during hemodialysis due to increased intraocular pressures. Using a higher sodium prescription resolved his symptoms and normalized his intraocular pressures. Read More

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http://dx.doi.org/10.1111/hdi.12718DOI Listing
February 2019

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000007. Epub 2019 Feb 14.

Master, Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. Acquisition of data.

Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000007DOI Listing
February 2019

An experimental study of exenatide effects on renal injury in diabetic rats1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000001. Epub 2019 Feb 14.

Master, Second Department of Endocrinology, Tai'an Central Hospital, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000001DOI Listing
February 2019

Near-infrared spectroscopy parameters in patients undergoing continuous venovenous hemodiafiltration.

Einstein (Sao Paulo) 2019 Feb 14;17(1):eAO4439. Epub 2019 Feb 14.

Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To investigate the impacts of continuous venovenous hemodiafiltration on the microcirculation in patients with acute kidney injury.

Methods: A prospective observational pilot study conducted in a 40-bed, open clinical-surgical intensive care unit of a private tertiary care hospital located in the city of São Paulo (SP), Brazil. Microcirculation was assessed using near-infrared spectroscopy by means of a 15mm probe placed over the thenar eminence. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019AO4439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377084PMC
February 2019

Time dependent p53 inhibition determines senescence attenuation and long term outcome after renal ischemia/reperfusion.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Children's Hospital, Medical School Hannover, Germany.

Inhibition of p53 has been shown to be an efficient strategy for ameliorating kidney ischemia/reperfusion (I/R) injury in experimental models. The therapeutic value of p53 siRNA based inhibition for I/R in renal transplantation is currently evaluated in clinical studies. While the major rationale for these studies is the suppression of pro-apoptotic properties, there are more, equally important injury response pathways regulated by p53. Read More

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http://dx.doi.org/10.1152/ajprenal.00333.2018DOI Listing
February 2019

Arteriovenous Conduits for Hemodialysis: How to Better Modulate the Pathophysiological Vascular Response to Optimize Vascular Access Durability.

Am J Physiol Renal Physiol 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology and Department of Medicine, University of Alabama at Birmingham, United States.

Vascular access is the lifeline for hemodialysis patients. Arteriovenous fistulas (AVFs) are the preferred vascular access but AVF maturation failure remains a significant clinical problem. Currently there are not any effective therapies available to prevent or treat AVF maturation failure. Read More

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http://dx.doi.org/10.1152/ajprenal.00440.2018DOI Listing
February 2019

Micro-RNA335-5p targeted inhibition of sKlotho and promoted oxidative stress-mediated aging of endothelial cells.

Biomark Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Geriatrics/West China hospital of SCU, Chengdu, China.

Aim: MiR-335-5p expression might induce endothelial cells (ECs) aging and target inhibit sKlotho. This study aimed to investigate whether oxidative stress evoked miR-335-5p expression and whether miR-335-5p-regulated ECs function through sKlotho.

Methods: The expression of miR-335-5p was detected in human umbilical vein endothelial cells treated with HO. Read More

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http://dx.doi.org/10.2217/bmm-2018-0430DOI Listing
February 2019

Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats.

Biomed Pharmacother 2019 Feb 19;112:108678. Epub 2019 Feb 19.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. Electronic address:

The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108678DOI Listing
February 2019

Giant calcified mass in a hemodialysis patient.

Kidney Int 2019 Mar;95(3):719

Department of Nephrology, Hospital Clínic - IDIBAPS (Institut d'Investigacions Biomèdiques August Pi I Sunyer), University of Barcelona, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.006DOI Listing

Embedded peritoneal dialysis catheter.

Kidney Int 2019 Mar;95(3):718

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.08.007DOI Listing

The quest for optimal control of relapses in children with nephrotic syndrome.

Kidney Int 2019 Mar;95(3):717

Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.kint.2019.01.002DOI Listing

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.

Kidney Int 2019 Mar;95(3):666-679

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 Valbonne Sophia Antipolis, France. Electronic address:

Autoantibodies against phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type 1 domain-containing 7A (THSD7A) are emerging as biomarkers to classify membranous nephropathy (MN) and to predict outcome or response to treatment. Anti-THSD7A autoantibodies are detected by Western blot and indirect immunofluorescence test (IIFT). Here, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) optimized for quantitative detection of anti-THSD7A autoantibodies. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.024DOI Listing

Uncovering genetic mechanisms of kidney aging through transcriptomics, genomics, and epigenomics.

Kidney Int 2019 Mar;95(3):624-635

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK; Division of Medicine and Manchester Heart Centre, Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

Nephrons scar and involute during aging, increasing the risk of chronic kidney disease. Little is known, however, about genetic mechanisms of kidney aging. We sought to define the signatures of age on the renal transcriptome using 563 human kidneys. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.029DOI Listing

Executive summary for the 2015 Annual Data Report of the China Kidney Disease Network (CK-NET).

Kidney Int 2019 Mar;95(3):501-505

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China; Peking-Tsinghua Center for Life Sciences, Beijing, China.

Chronic kidney disease (CKD) has received increased attention as a leading public health problem worldwide. Globally surveillance systems for kidney disease are still lacking, especially in developing countries like China, which constitutes an obstacle to develop effective preventive strategies. China Kidney Disease Network (CK-NET) was initiated in 2014 and further developed in accordance with the national strategy of prompting Big Data application in China. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183081
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http://dx.doi.org/10.1016/j.kint.2018.11.011DOI Listing
March 2019
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The elusive podocyte crossmatch for recurrent focal segmental glomerulosclerosis.

Kidney Int 2019 Mar;95(3):498-500

Peggy and Harold Katz Family Drug Discovery Center, University of Miami, Miller School of Medicine, Miami, Florida, USA; Katz Family Division of Nephrology and Hypertension, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA. Electronic address:

Focal segmental glomerulosclerosis is a glomerular disorder with a high rate of recurrence. Although kidney biopsies remain the gold standard to diagnose recurrent focal segmental glomerulosclerosis, non-invasive prognostic assays could facilitate preventive treatments and offer insight into disease pathogenicity and heterogeneity. Srivastava et al. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.032DOI Listing

Renal biopsy findings in patients with extreme obesity: more heterogeneous than you think.

Kidney Int 2019 Mar;95(3):495-498

Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

The number of obese and morbidly obese patients is increasing and so is the burden of renal disease in these patients. In a large series of biopsies from the morbidly obese patient population, Choung et al. show that there is heterogeneity in the renal disease affecting this population. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.008DOI Listing

Kidney aging: an irresistible slope.

Authors:
Imari Mimura

Kidney Int 2019 Mar;95(3):492-494

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address:

Kidney aging is a multifactorial process. Using genome-wide database analysis, Rowland et al. identified testis-specific Y-encoded-like protein 5 as a candidate age-related renal gene, and reported that with aging, testis-specific Y-encoded-like protein 5 expression decreases in response to increased testis-specific Y-encoded-like protein 5 promoter methylation. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.036DOI Listing

Tubule repair: with a little help from my "unexpected" friends.

Kidney Int 2019 Mar;95(3):487-489

Department of Biomedical Experimental and Clinical Sciences "Mario Serio," University of Florence, Florence, Italy; Excellence Center DENOTHE, University of Florence, Florence, Italy; Nephrology and Dialysis Unit, Meyer Children's University Hospital, Florence, Italy. Electronic address:

Tubulointerstitial fibrosis is considered a hallmark of maladaptive repair processes after tubular injury leading to chronic kidney disease. Nakamura and colleagues show that, upon injury, myofibroblasts promote epithelial repair by producing retinoic acid in place of injured tubular cells. These results suggest that resident fibroblasts turning into myofibroblasts maintain a cross-talk that protects tubular epithelial cells from injury and can restore tissue integrity and functionality, challenging the concept that fibrosis is only detrimental in nature. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.019DOI Listing

Iron and oxygen sensing: discovering intricate links.

Authors:
Kai-Uwe Eckardt

Kidney Int 2019 Mar;95(3):482-484

Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2019.01.003DOI Listing

Citius, altius, fortius . . . . faster, higher, stronger.

Kidney Int 2019 Mar;95(3):476-478

The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.kint.2019.01.001DOI Listing

Patient expectations and experiences of remote monitoring for chronic diseases: Systematic review and thematic synthesis of qualitative studies.

Int J Med Inform 2019 Apr 29;124:78-85. Epub 2019 Jan 29.

Department of Medicine, University of Otago Christchurch, 8140, New Zealand; Department of Nephrology, Canterbury District Health Board, Christchurch, New Zealand.

Objectives: To describe the range of patients' beliefs, attitudes, expectations, and experiences of remote monitoring for chronic conditions across different healthcare contexts and populations.

Design: We searched MEDLINE, Embase, PsychINFO, and CINAHL, Google Scholar, and reference lists of related studies through to July 2017. Thematic synthesis was used to analyse the findings of the primary studies. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2019.01.013DOI Listing

Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells.

Cell Cycle 2019 Feb 20. Epub 2019 Feb 20.

a Department of Nephrology , the Second Affiliated Hospital of Nanchang University , Nanchang , China.

Glomerular endothelial cell injury plays an important role in the development and progression of diabetic nephropathy (DN). The expression and function of klotho in glomerular endothelial cells remain unclear. Thus, this study aimed to investigate the expression and the functional role of klotho in DN progression in mice and in high glucose (HG)-induced cell injury of human renal glomerular endothelial cells (HRGECs) and the underlying mechanism. Read More

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http://dx.doi.org/10.1080/15384101.2019.1580495DOI Listing
February 2019

Outcomes of radiocephalic fistula created by nephrologists.

J Vasc Access 2019 Feb 20:1129729819830361. Epub 2019 Feb 20.

1 Department of Nephrology, SGPGI, Lucknow, India.

Introduction:: Arteriovenous fistula is considered as gold standard access for maintenance hemodialysis. Due to increasing burden of end-stage renal disease requiring dialysis, it is important for nephrologists to complement creation of arteriovenous fistula to meet the demand.

Methods:: This retrospective study was designed to assess the outcomes of arteriovenous fistula made by nephrologists at a tertiary care center from North India. Read More

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http://dx.doi.org/10.1177/1129729819830361DOI Listing
February 2019

Severe congenital nephrogenic diabetes insipidus in a compound heterozygote with a new large deletion of the AQP2 gene. A case report.

Mol Genet Genomic Med 2019 Feb 19:e568. Epub 2019 Feb 19.

La Paz University Hospital, Medical and Molecular Genetics Institute (INGEMM), IdiPAZ, Madrid, Spain.

Background: Congenital nephrogenic diabetes insipidus (NDI) is a rare condition characterized by severe polyuria, due to the inability of the kidneys to concentrate urine in response to arginine vasopressin (AVP). In the majority of the cases, the disease shows an X-linked inherited pattern, although an autosomal recessive inheritance was also observed.

Methods: We report a patient with a severe NDI diagnosed during the neonatal period. Read More

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http://dx.doi.org/10.1002/mgg3.568DOI Listing
February 2019

Burden, access and disparities in kidney disease.

J Ren Care 2019 Mar;45(1):4-8

Faculty of Medicine, Nephrology Unit, Department of Internal Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1111/jorc.12269DOI Listing

Development and evaluation of dedicated low clearance transplant clinics for patients with failing kidney transplants.

J Ren Care 2019 Mar;45(1):51-58

University of Birmingham College of Medical and Dental Sciences, Birmingham, UK.

Background: Recipients with failing kidney transplants (RFKTs) may receive sub-optimal care compared with patients with native kidney disease. The aim of this study is to compare the outcomes of RFKTs managed in a dedicated low clearance transplant clinic (LCTC) compared with those attending a general transplant clinic.

Methods: We undertook a retrospective analysis of patients with failing kidney transplants comparing two clinics-a LCTC versus a general transplant clinic. Read More

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http://dx.doi.org/10.1111/jorc.12268DOI Listing

Klippel-Feil syndrome as a novel feature of Schimke immunoosseous dysplasia.

Am J Med Genet A 2019 Feb 19. Epub 2019 Feb 19.

Department of Paediatrics, Midland Regional Hospital, Mullingar, County Westmeath, Ireland.

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http://dx.doi.org/10.1002/ajmg.a.61087DOI Listing
February 2019

Deciphering the relative roles of matrix metalloproteinase- and plasmin-mediated matrix degradation during capillary morphogenesis using engineered hydrogels.

J Biomed Mater Res B Appl Biomater 2019 Feb 19. Epub 2019 Feb 19.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.

Extracellular matrix (ECM) remodeling is essential for the process of capillary morphogenesis. Here we employed synthetic poly(ethylene glycol) (PEG) hydrogels engineered with proteolytic specificity to either matrix metalloproteinases (MMPs), plasmin, or both to investigate the relative contributions of MMP- and plasmin-mediated ECM remodeling to vessel formation in a 3D-model of capillary self-assembly analogous to vasculogenesis. We first demonstrated a role for both MMP- and plasmin-mediated mechanisms of ECM remodeling in an endothelial-fibroblast co-culture model of vasculogenesis in fibrin hydrogels using inhibitors of MMPs and plasmin. Read More

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http://dx.doi.org/10.1002/jbm.b.34341DOI Listing
February 2019

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in inflammation and protein leakage in urine in DN patients. Chemerin and its receptor ChemR23 are inducers of inflammation. Read More

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http://dx.doi.org/10.1111/jcmm.14237DOI Listing
February 2019

Effect of Topical Baclofen 5% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial.

J Gastrointest Surg 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Pharmacy, Nephrology and Kidney Transplant Research Center, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

Background: Baclofen is an agonist for a subtype of gamma-amino butyric acid (GABA-B) receptors and traditionally been used for the systemic treatment of spasticity. Topical application of baclofen has been shown to reduce pain in patients with localized neuropathic pain.

Objectives: In this study, we investigate the efficacy of baclofen cream (5%) in reducing postoperative pain and analgesic requirement after open hemorrhoidectomy. Read More

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http://dx.doi.org/10.1007/s11605-019-04147-7DOI Listing
February 2019

Regional prescription surveillance of phosphate binders in the western Saitama area: the substantial role of ferric citrate hydrate in improving serum phosphorus levels and erythropoiesis.

Clin Exp Nephrol 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology, Faculty of Medicine, Saitama Medical University, 38, Morohongo, Moroyama-machi, Irumagun, Saitama, Japan.

Background: In April 2015, five types of phosphate binders (PBs) were available by prescription in Japan, namely calcium carbonate, sevelamer hydrochloride, lanthanum carbonate, bixalomer, and ferric citrate hydrate (FeC). FeC reduces serum phosphorus levels and increases the body's iron stores. However, it is unclear whether FeC lowers serum phosphorus relative to other agents in a regional practical setting. Read More

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http://dx.doi.org/10.1007/s10157-019-01715-8DOI Listing
February 2019

Effects of renal denervation on blood pressure in hypertensive patients with end-stage renal disease: a single centre experience.

Clin Exp Nephrol 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Ulmenweg 18, 91054, Erlangen, Germany.

Background: Sympathetic nerve activity is a hallmark of hypertension in end-stage renal disease (ESRD). An initial proof-of-concept study implies that renal denervation (RDN) is feasible and safe in RDN, but overall data are limited.

Methods: In this single-centre prospective pilot study six patients with ESRD and treatment resistant hypertension were consecutively included. Read More

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http://link.springer.com/10.1007/s10157-019-01697-7
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http://dx.doi.org/10.1007/s10157-019-01697-7DOI Listing
February 2019
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Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study.

Rheumatol Int 2019 Feb 19. Epub 2019 Feb 19.

Department of Molecular Biology-Genetics and Biotechnology, Dr. Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Centre, Graduate School of Science, Engineering and Technology, İstanbul Technical University, Ayazağa Campus, Maslak, 34469, Istanbul, Turkey.

Systemic autoinflammatory diseases (sAIDs) are a heterogeneous group of disorders, having monogenic inherited forms with overlapping clinical manifestations. More than half of patients do not carry any pathogenic variant in formerly associated disease genes. Here, we report a cross-sectional study on targeted Next-Generation Sequencing (NGS) screening in patients with suspected sAIDs to determine the diagnostic utility of genetic screening. Read More

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http://dx.doi.org/10.1007/s00296-019-04252-5DOI Listing
February 2019

Diffusion tensor imaging of the kidney in healthy controls and in children and young adults with autosomal recessive polycystic kidney disease.

Abdom Radiol (NY) 2019 Feb 19. Epub 2019 Feb 19.

Division of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objective: To compare diffusion tensor imaging (DTI) of the kidneys and its derived parameters in children with autosomal recessive polycystic kidney disease (ARPKD) versus healthy controls.

Methods: In a prospective IRB-approved study, we evaluated the use of DTI to compare kidney parenchyma FA values in healthy controls (age-matched children with no history of renal disease) versus patients with ARPKD. A 20-direction DTI with b-values of b = 0 s/mm and b = 400 s/mm was used to acquire data in coronal direction using a fat-suppressed spin-echo echo-planar sequence. Read More

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http://dx.doi.org/10.1007/s00261-019-01933-4DOI Listing
February 2019

Oestrogen inhibits PTPRO to prevent the apoptosis of renal podocytes.

Exp Ther Med 2019 Mar 14;17(3):2373-2380. Epub 2019 Jan 14.

Department of Medical Ultrasound Center, The Northwest Women's and Children's Hospital, Xi'an, Shaanxi 710061, P.R. China.

Podocytes are a major component of the glomerular filtration membrane, and their apoptosis is involved in a variety of nephrotic syndromes. In the current study, the effects and molecular mechanisms of oestrogen on the proliferation and apoptosis of podocytes were investigated to elucidate the role of oestrogen in the pathogenesis of childhood nephrotic syndrome. The cell proliferation of mouse renal podocytes (MPC-5) and human primary renal podocytes was promoted by 17β-oestradiol (E2) in what appear to be a time-dependent manner. Read More

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http://dx.doi.org/10.3892/etm.2019.7167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364249PMC

Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis.

Exp Ther Med 2019 Mar 14;17(3):2279-2283. Epub 2019 Jan 14.

Department of Nephrology, Yanan University Affiliated Hospital, Yanan, Shaanxi 716000, P.R. China.

Expression levels of interleukin-17 (IL-17) and IL-34 was investigated to analyze the influencing factors for prognosis in patients with lupus nephritis (LN). Clinical data of 45 patients (LN group) treated and diagnosed with LN via renal biopsy in Yanan University Affiliated Hospital from October 2010 to October 2012 and 50 healthy subjects (control group) were analyzed retrospectively. Levels of serum IL-17 and IL-34 were detected via enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.3892/etm.2019.7168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364195PMC

Kimura's disease associated with IgA nephropathy: A case report.

Exp Ther Med 2019 Mar 17;17(3):1837-1840. Epub 2018 Dec 17.

Department of Nephrology, Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Kimura's disease (KD) is a rare chronic inflammatory disorder of unknown etiology that manifests as painless subcutaneous lesions in the head and neck. It primarily affects young Asian males and is characterized by peripheral eosinophilia and elevated levels of serum Immunoglobulin (Ig)E. Histologically, a variety of renal lesions have been observed in patients with KD, although IgA nephropathy is rarely reported. Read More

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http://dx.doi.org/10.3892/etm.2018.7103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364220PMC

Clinical significance of autoantibodies in the assessment and treatment of idiopathic membranous nephropathy.

Exp Ther Med 2019 Mar 18;17(3):1825-1830. Epub 2018 Dec 18.

Department of Nephrology, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

The present study aimed to explore the correlation between the dynamic serum levels of phospholipase A2 receptor (PLA2R), aldose reductase (AR) and superoxide dismutase 2(SOD2) antibodies with disease activity and treatment response in patients with idiopathic membranous nephropathy (IMN). The present study included 56 patients with IMN who were diagnosed through a renal biopsy and presenting with nephrotic syndrome. The patients were divided into two treatment groups: One treated with cyclophosphamide (CTX) and one with tacrolimus (FK506). Read More

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http://dx.doi.org/10.3892/etm.2018.7108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364219PMC

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.

Sci Rep 2019 Feb 19;9(1):2256. Epub 2019 Feb 19.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting liver fibrosis and portal hypertension (PTH). Specific delivery of ROCK-inhibitor Y-27632 (Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and fibrogenesis. In decompensated cirrhosis, presence of ascites is associated with reduced renal perfusion. Read More

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http://www.nature.com/articles/s41598-019-38678-5
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http://dx.doi.org/10.1038/s41598-019-38678-5DOI Listing
February 2019
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Comparing the effects of intravenous and subcutaneous Erythropoietin on blood indices in hemodialysis patients.

Sci Rep 2019 Feb 19;9(1):2284. Epub 2019 Feb 19.

School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Erythropoietin is used routinely in hemodialysis patients to increase hemoglobin levels in patients with ESRD and anemia. Considering the importance of anemia in hemodialysis patients and its complications, in this study, the effect of erythropoietin administration on blood parameters by comparing the methods of subcutaneous and intravenous administrations was investigated. The research was done as a retrospective descriptive-analytic study. Read More

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http://www.nature.com/articles/s41598-018-38193-z
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http://dx.doi.org/10.1038/s41598-018-38193-zDOI Listing
February 2019
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Suppression of autophagic activity by Rubicon is a signature of aging.

Nat Commun 2019 Feb 19;10(1):847. Epub 2019 Feb 19.

Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.

Autophagy, an evolutionarily conserved cytoplasmic degradation system, has been implicated as a convergent mechanism in various longevity pathways. Autophagic activity decreases with age in several organisms, but the underlying mechanism is unclear. Here, we show that the expression of Rubicon, a negative regulator of autophagy, increases in aged worm, fly and mouse tissues at transcript and/or protein levels, suggesting that an age-dependent increase in Rubicon impairs autophagy over time, and thereby curtails animal healthspan. Read More

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http://dx.doi.org/10.1038/s41467-019-08729-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381146PMC
February 2019

Amelioration of Uremic Toxin Indoxyl Sulfate-Induced Osteoblastic Calcification by SET Domain Containing Lysine Methyltransferase 7/9 Protein.

Nephron 2019 Feb 15:1-8. Epub 2019 Feb 15.

Department of Nephrology, Zhongshan Hospital, University of Fudan, Shanghai, China.

Background: Vascular calcification (VC) is a very common phenomenon in patients with chronic kidney disease (CKD). It has been reported that some histone methylation play a role in VC as an epigenetic regulator. Indoxyl sulfate (IS) is a protein-bound uremic toxin that has been proven as one of the major risk factors of cardiovascular disease in CKD. Read More

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http://dx.doi.org/10.1159/000495885DOI Listing
February 2019

Burden, Access, and Disparities in Kidney Disease.

Nephron 2019 Feb 18:1-8. Epub 2019 Feb 18.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world. In many settings, rates of kidney disease and the provision of its care are defined by socioeconomic, cultural, and political factors leading to significant disparities. Read More

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http://dx.doi.org/10.1159/000495557DOI Listing
February 2019

Reversal Unilateral Ureteral Obstruction: A Mice Experimental Model.

Nephron 2019 Feb 15:1-10. Epub 2019 Feb 15.

Experimental Nephrology, Department of Ciències Clíniques, Universitat de Barcelona, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Hospitalet de Llobregat, Barcelona,

Background/aims: Reversible unilateral ureteral obstruction (R-UUO) is a model of renal injury used to study the structural and functional recovery of the kidneys after relief of the obstruction. This model has a prominent potential for the study of inflammatory and immune processes, cellular and tissue regeneration. Here we sought to describe a model of renal injury and repair R-UUO in mice. Read More

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http://dx.doi.org/10.1159/000497119DOI Listing
February 2019