131,589 results match your criteria Nephrology nursing journal : journal of the American Nephrology Nurses' Association[Journal]


Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing

Corrigendum.

Authors:

Nephrology (Carlton) 2019 May;24(5):586

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http://dx.doi.org/10.1111/nep.13590DOI Listing

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury.

Am J Nephrol 2019 Apr 17;49(6):449-459. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Center for Kidney Diseases (VCKD) and Integrated Program for AKI Research (VIP-AKI), Nashville, Tennessee, USA.

Background: Acute kidney injury (AKI) survivors are at risk for chronic kidney disease, recurrent AKI, and cardiovascular disease. The transition from hospital to ambulatory care is an opportunity to reduce these sequelae by launching self-care plans through effective patient education. How well AKI survivors are informationally prepared to apply kidney-specific self-care is unknown. Read More

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https://www.karger.com/Article/FullText/499862
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http://dx.doi.org/10.1159/000499862DOI Listing
April 2019
1 Read

Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future.

Cardiorenal Med 2019 Apr 17;9(4):222-228. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1159/000498916DOI Listing

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.

Cell Rep 2019 Apr;27(3):699-707.e4

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS). The Keap1-Nrf2 antioxidant system also participates in T cell differentiation and inflammation, but its role in innate T cell development and functions remains unclear. We report that T cell-specific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.052DOI Listing

Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort.

PLoS One 2019 17;14(4):e0215575. Epub 2019 Apr 17.

Nephrology Training Program at Houston Methodist Hospital, Houston, Texas, United States of America.

Background And Objectives: HIV-infected patients are at risk for developing chronic kidney disease (CKD), defined by estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2. Our purpose was to understand the genesis of CKD in HIV patients from a large urban clinic in Houston, Texas, USA, and to characterize progression of CKD in the cohort. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215575PLOS

AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis and ameliorates ischemic AKI .

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Medicine / Nephroloy, University of Illinois, Chicago, United States.

We have reported that preconditioning renal tubular cells (RTCs) with A-769662 (a pharmacologic activator of AMPK) reduces apoptosis of RTCs induced by subsequent stress, and ameliorates the severity of ischemic AKI in mice. In this study we examined the role of the PI3K/Akt pathway in mediating these effects. To confirm that any observed novel effects of A-769662 are mediated specifically by AMPK, we developed knockdown ("KD") RTCs using shRNA. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00553.2018
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http://dx.doi.org/10.1152/ajprenal.00553.2018DOI Listing
April 2019
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Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department Of Nephrology, The First Affiliated Hospital of Nanjing Medical University.

Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage and inflammatory responses, are closely linked to cisplatin-induced nephrotoxicity. Adenosine, emerging as a key regulatory molecule, is mostly protective in the pathophysiology of inflammatory diseases. Previous study showed that some of the adenosine receptors led to renal protection against ischemia-reperfusion injury. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00385.2018
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http://dx.doi.org/10.1152/ajprenal.00385.2018DOI Listing
April 2019
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The renin-angiotensin system promotes colonic inflammation by inducing T17 activation via the JAK2/STAT pathway.

Am J Physiol Gastrointest Liver Physiol 2019 Apr 17. Epub 2019 Apr 17.

Medicine, The University of Chicago, United States.

Previous studies suggest that the renin-angiotensin system (RAS) is pathogenic factor for colitis. The goal of this study was to elucidate the molecular mechanism whereby angiotensin II (Ang II) promotes colonic inflammation. We found that renin was highly induced in colonic biopsies from patients with ulcerative colitis or Crohn's disease, and colonic renin and Ang II levels were markedly increased in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model, indicating that the colonic RAS is activated in colitis. Read More

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http://dx.doi.org/10.1152/ajpgi.00053.2019DOI Listing

Most common histopathological patterns of the Minas Gerais Association of the Centers of Nephrology.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):441-445. Epub 2019 Apr 11.

MD, Nephrologist, MSc in Science from Unifesp, São Paulo/ São João de Deus Hospital - Brasil.

Introduction: We analyzed the distribution and frequency of glomerular diseases in patients biopsied between 1992 and 2016 in centers that make up the AMICEN (Minas Gerais Association of Nephrology Centers).

Methods: We analyzed the biopsy reports of patients from 9 AMICEN nephrology centers. We took note of their age, gender, ultrasound use, post-biopsy resting time, whether the kidney was native or a graft, number of glomeruli and indication for the biopsy. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.441DOI Listing

Acute Community-Acquired Bacterial Meningitis: Update on Clinical Presentation and Prognostic factors.

New Microbiol 2019 Apr 17;41(2). Epub 2019 Apr 17.

Department of Infectious Diseases, Hospital Fundación Jiménez-Díaz, Universidad Autonoma, Madrid, Spain.

The epidemiology of community-acquired bacterial meningitis (CABM) in adults has changed significantly in the past several years. Despite substantial improvement in patient care, CABM remains a major cause of morbidity and mortality. Thus, new prognostic factors could help improve patient stratification. Read More

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Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting β-catenin activity.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, China.

Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast-induced-nephropathy and other kidney diseases. Read More

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http://dx.doi.org/10.1111/jcmm.14340DOI Listing

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Key Laboratory of Kidney Disease and Blood Purification of Hunan Province, Second Xiangya Hospital at Central South University, Changsha, China.

Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment. Nicotinamide (NAM), a member of water-soluble vitamin B family, was recently suggested to have a therapeutic potential for acute kidney injury (AKI) in mice and humans. The effect of NAM on chronic kidney pathologies, including renal fibrosis, is unknown. Read More

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http://doi.wiley.com/10.1111/jcmm.14285
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http://dx.doi.org/10.1111/jcmm.14285DOI Listing
April 2019
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Augmenter of liver regeneration protects the kidney from ischaemia-reperfusion injury in ferroptosis.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Nephrology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, People's Republic of China.

Acute kidney injury (AKI) is a common and severe clinical condition with high morbidity and mortality. Ischaemia-reperfusion (I/R) injury remains the major cause of AKI in the clinic. Ferroptosis is a recently discovered form of programmed cell death (PCD) that is characterized by iron-dependent accumulation of reactive oxygen species (ROS). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.14302
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http://dx.doi.org/10.1111/jcmm.14302DOI Listing
April 2019
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Effect of LDL apheresis for nephrotic idiopathic membranous nephropathy as initial induction therapy.

Ther Apher Dial 2019 Apr 17. Epub 2019 Apr 17.

Department of Nephrology, Japanese Red Cross Nagoya Daini Hospital, Nagoya, Aichi, Japan.

Low-density lipoprotein apheresis (LDL-A) has been used for nephrotic syndrome (NS) by focal segmental glomerulosclerosis in Japan. Idiopathic membranous nephropathy (iMN) can also cause treatment-resistant NS. Therefore we investigated the effect of LDL-A during initial induction for it. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-9987.12
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http://dx.doi.org/10.1111/1744-9987.12811DOI Listing
April 2019
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Comparison of creatinine and cystatin C for estimation of glomerular filtration rate in pediatric patients after Fontan operation.

Congenit Heart Dis 2019 Apr 16. Epub 2019 Apr 16.

Section of Pediatric Cardiology, Department of Pediatrics, University of Colorado, Children's Hospital Colorado, Aurora, Colorado.

Background: There are several limitations when using creatinine to estimate glomerular filtration rate, especially in children with chronic medical conditions who are at high risk of kidney dysfunction. Cystatin C has been the recent focus of research as a replacement biomarker for creatinine. Our objective was to compare the 2 biomarkers in pediatric single-ventricle heart disease patients who have undergone the Fontan operation. Read More

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http://dx.doi.org/10.1111/chd.12776DOI Listing

Periodontitis as the risk factor of chronic kidney disease: Mediation analysis.

J Clin Periodontol 2019 Apr 16. Epub 2019 Apr 16.

Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Aim: To determine sequences and magnitude of causality among periodontitis, diabetes and chronic kidney disease (CKD) by mediation analysis.

Methods: Ten-year-data were retrieved from the Electric Generation Authority of Thailand (EGAT) study. A cohort of 2,635 subjects was identified with no CKD at baseline. Read More

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http://dx.doi.org/10.1111/jcpe.13114DOI Listing

Combination chemotherapy with gemcitabine and nab-paclitaxel for a metastatic pancreatic ductal adenocarcinoma patient undergoing hemodialysis.

Clin J Gastroenterol 2019 Apr 16. Epub 2019 Apr 16.

Gastroenterology Division, Yokohama City University, Graduate School of Medicine, Yokohama, Japan.

In cancer patients, impairment of kidney function is not uncommon. Recently, the efficacy of the combination of gemcitabine and nab-paclitaxel for pancreatic ductal adenocarcinoma (PDAC) patients has been reported, however, there is no recommendation for dose and administration to patients undergoing hemodialysis (HD). A 66-year-old man began receiving HD for chronic renal failure 4 years previously. Read More

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http://dx.doi.org/10.1007/s12328-019-00976-wDOI Listing

Primary Care Physicians' Perceived Barriers to Nephrology Referral and Co-management of Patients with CKD: a Qualitative Study.

J Gen Intern Med 2019 Apr 16. Epub 2019 Apr 16.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Background: Effective co-management of patients with chronic kidney disease (CKD) between primary care physicians (PCPs) and nephrologists is increasingly recognized as a key strategy to ensure the delivery of efficient and high-quality CKD care. However, the co-management of patients with CKD remains suboptimal.

Objective: We aimed to identify PCPs' perceptions of key barriers and facilitators to effective co-management of patients with CKD at the PCP-nephrology interface. Read More

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http://dx.doi.org/10.1007/s11606-019-04975-yDOI Listing

Effect of Sodium Glucose Co-Transporter 2 Inhibitors on Liver Fat Mass and Body Composition in Patients with Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.

Clin Drug Investig 2019 Apr 16. Epub 2019 Apr 16.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Background And Objective: Sodium glucose co-transporter 2 inhibitors increase urinary glucose excretion and reduce visceral adiposity and body weight, but their efficacy on patients with nonalcoholic fatty liver disease has not been sufficiently investigated. The aim of this study was to assess the effect of sodium glucose co-transporter 2 inhibitors on liver fat mass and body composition in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus.

Methods: We retrospectively analyzed 17 patients with nonalcoholic fatty liver disease and type 2 diabetes who received sodium glucose co-transporter 2 inhibitors between November 2016 and July 2017. Read More

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http://dx.doi.org/10.1007/s40261-019-00785-6DOI Listing

Predictors of chemotherapy-induced severe anemia in cancer patients receiving chemotherapy.

Support Care Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiation Oncology, Shohada-e-Tajrish Medical Center, Shahid Beheshti University of Medical Sciences, Shahrdari St, Tajrish Sq, Tehran, 1989934148, Iran.

Purpose: Chemotherapy-induced anemia is a frequent complication of systemic chemotherapy and is associated with decreased functional capacity and quality of life. The objective of this study was to identify the candidate variables most likely to be associated with chemotherapy-induced severe anemia (hemoglobin < 8 g/dL) in patients treated with cytotoxic chemotherapy.

Methods: A total of 14 clinical and laboratory covariates were prospectively evaluated at baseline in a cohort of consecutive cancer patients receiving cytotoxic chemotherapy. Read More

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http://dx.doi.org/10.1007/s00520-019-04780-7DOI Listing

Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?

Urolithiasis 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine/Division of Nephrology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI, 53226, USA.

Urine proteins are thought to control calcium oxalate stone formation, but over 1000 proteins have been reported in stone matrix obscuring their relative importance. Proteins critical to stone formation should be present at increased relative abundance in stone matrix compared to urine, so quantitative protein distribution data were obtained for stone matrix compared to prior urine proteome data. Matrix proteins were isolated from eight stones (> 90% calcium oxalate content) by crystal dissolution and further purified by ultradiafiltration (> 10 kDa membrane). Read More

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http://link.springer.com/10.1007/s00240-019-01131-3
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http://dx.doi.org/10.1007/s00240-019-01131-3DOI Listing
April 2019
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Adolescents with urinary stones have elevated urine levels of inflammatory mediators.

Urolithiasis 2019 Apr 16. Epub 2019 Apr 16.

Division of Nephrology, Department of Pediatrics, Indiana University, Bloomington, USA.

Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a metabolic process associated with chronic kidney disease and cardiovascular disease. These aforementioned stone-associated conditions may have pediatric origins. Read More

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http://dx.doi.org/10.1007/s00240-019-01133-1DOI Listing

Association between timing of peritoneal dialysis initiation and mortality in end-stage renal disease.

Chronic Dis Transl Med 2019 Mar 21;5(1):37-43. Epub 2018 Dec 21.

Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

Despite the widespread use of chronic dialysis for end-stage renal disease (ESRD), there is no consensus on the optimal timing of initiating renal replacement therapy. Over the past decade, a worldwide trend toward increasing glomerular filtration rate at the initiation of dialysis has been noted. However, available data indicate that early dialysis has no survival benefit or is harmful. Read More

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http://dx.doi.org/10.1016/j.cdtm.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449773PMC

Another Victim of Rapid Weight Loss?

Kidney Int Rep 2019 Apr 23;4(4):633. Epub 2019 Jan 23.

Gazi Universitesi Tip Fakultesi, Nephrology, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.ekir.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451078PMC

Pauci-Immune Crescentic Glomerulonephritis due to Disseminated Histoplasmosis.

Kidney Int Rep 2019 Apr 9;4(4):629-632. Epub 2019 Jan 9.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451085PMC

Adenine Phosphoribosyltransferase Deficiency Due to Novel Mutation.

Kidney Int Rep 2019 Apr 18;4(4):624-628. Epub 2018 Dec 18.

Division of Pediatric Nephrology, Lady Hardinge Medical College and associated Kalawati Saran Children Hospital, New Delhi, India.

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http://dx.doi.org/10.1016/j.ekir.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451083PMC
April 2019
1 Read

Rituximab for Anti-Glomerular Basement Membrane Disease.

Kidney Int Rep 2019 Apr 17;4(4):614-618. Epub 2018 Dec 17.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451084PMC

Cumulative Exposure to Frequent Intradialytic Hypotension Associates With New-Onset Dementia Among Elderly Hemodialysis Patients.

Kidney Int Rep 2019 Apr 14;4(4):603-606. Epub 2019 Jan 14.

University of North Carolina (UNC) Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, UNC School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1016/j.ekir.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451081PMC

Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC

Glomerular C3 Deposition Is an Independent Risk Factor for Allograft Failure in Kidney Transplant Recipients With Transplant Glomerulopathy.

Kidney Int Rep 2019 Apr 4;4(4):582-593. Epub 2019 Feb 4.

Department of Medicine, Division of Nephrology, University of Wisconsin, Madison, Wisconsin, USA.

Introduction: Transplant glomerulopathy (TG) becomes increasingly prevalent in kidney transplant recipients over time, and it is strongly associated with allograft failure. To date, our prognostic biomarkers and understanding of the processes of immunologic injury in TG are limited.

Methods: This is a retrospective cohort analysis of kidney transplant recipients with TG (double contours of the glomerular basement membrane as defined by the chronic glomerulopathy score). Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451156PMC

Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury.

Kidney Int Rep 2019 Apr 28;4(4):571-581. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.

Introduction: After dialysis-requiring acute kidney injury (AKI-D), recovery of sufficient kidney function to discontinue dialysis is an important clinical and patient-oriented outcome. Predicting the probability of recovery in individual patients is a common dilemma.

Methods: This cohort study examined all adult members of Kaiser Permanente Northern California who experienced AKI-D between January 2009 and September 2015 and had predicted inpatient mortality of <20%. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451155PMC

Prevalence and Demographics of CKD in Canadian Primary Care Practices: A Cross-sectional Study.

Kidney Int Rep 2019 Apr 21;4(4):561-570. Epub 2019 Jan 21.

Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.

Introduction: Surveillance systems enable optimal care delivery and appropriate resource allocation, yet Canada lacks a dedicated surveillance system for chronic kidney disease (CKD). Using data from the Canadian Primary Care Sentinel Surveillance Network (CPCSSN), a national chronic disease surveillance system, this study describes the geographic, sociodemographic, and clinical variations in CKD prevalence in the Canadian primary care context.

Methods: This cross-sectional study included 559,745 adults in primary care in 5 provinces across Canada from 2010 through 2015. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451150PMC

Understanding Long-term Remission Off Therapy in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Kidney Int Rep 2019 Apr 28;4(4):551-560. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, and the Kidney Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Introduction: In antineutrophil cytoplasmic antibody-associated (ANCA) vasculitis, relapse risk and long-term immunosuppressive therapy are problematic. Stopping immunotherapy has not been well described.

Methods: The Glomerular Disease Collaborative Network ANCA vasculitis inception cohort was evaluated. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451087PMC

A Twin Study of Genetic Influences on Nephrolithiasis in Women and Men.

Kidney Int Rep 2019 Apr 29;4(4):535-540. Epub 2018 Nov 29.

Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Background: Nephrolithiasis is a complex phenotype influenced by both genetic and environmental factors. Previously we found a genetic component to stone disease using a sample of male twin pairs. We now report on the genetic contribution to stones in a sample of female and male twin pairs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183031
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http://dx.doi.org/10.1016/j.ekir.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451147PMC
April 2019
1 Read

Predicting Outcomes in Acute Kidney Injury Survivors: Searching for the Crystal Ball.

Kidney Int Rep 2019 Apr 28;4(4):520-521. Epub 2019 Feb 28.

Division of Nephrology, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ekir.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451151PMC

The Utility of a National Surveillance Network to Estimate CKD Prevalence and Identify High-Risk Populations in Primary Care.

Authors:
Maya K Rao

Kidney Int Rep 2019 Apr 12;4(4):513-515. Epub 2019 Feb 12.

Division of Nephrology, Columbia University College of Physicians & Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1016/j.ekir.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451146PMC

Classical and Modern Genetic Approach to Kidney Stone Disease.

Kidney Int Rep 2019 Apr 17;4(4):507-509. Epub 2019 Jan 17.

Nephrology and Dialysis Unit, Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.ekir.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451152PMC

Impact of Using Alternative Graft Function Endpoints: A Secondary Analysis of a Kidney Transplant Trial.

Transplant Direct 2019 Apr 19;5(4):e439. Epub 2019 Mar 19.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada.

Background: Nephrology trials assessing the impact of interventions on "standard" outcomes, such as doubling of creatinine, end-stage renal disease (ESRD), and/or death, are difficult to conduct given the time required for endpoints to accrue. The objective of this study was to determine if using lesser declines in kidney function would alter the interpretation of a previous randomized controlled trial.

Methods: This study was a secondary analysis of a kidney transplant trial comparing the use of a 40% or greater, 30% or greater, or 20% or greater decline in estimated glomerular filtration rate (eGFR) as a substitute for doubling of serum creatinine. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445653PMC

Differences in Gene Expression in Older Compared With Younger Kidney Transplant Recipients.

Transplant Direct 2019 Apr 4;5(4):e436. Epub 2019 Mar 4.

Division of Hematology-Oncology, Department of Medicine, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Background: For the growing numbers of older transplant patients, increased incidence of infection and death compared with younger patients may limit the many benefits provided by transplantation. However, little is known about age-associated immune dysfunction in the older transplant recipient.

Methods: A cohort of 60 kidney transplant recipients, 23 older (≥ 60y) and 37 younger (30-59y), matched on antithymocyte induction and donor type (living vs deceased) was evaluated. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445656PMC

Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells.

Biomed Res Int 2019 12;2019:3851718. Epub 2019 Mar 12.

Division of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430070, China.

We examined whether and how uric acid induces epithelial to mesenchymal transition (EMT) in renal tubular cells, along with the mechanism by which telmisartan acts on uric acid-induced renal injury. Rat renal proximal tubular epithelial cells (NRK-52E) were exposed to various concentrations of uric acid in the presence or absence of telmisartan. Treatment with uric acid increased the expression of -SMA, decreased the expression of E-cadherin, and promoted EMT in NRK-52E cells. Read More

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http://dx.doi.org/10.1155/2019/3851718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434300PMC

Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.

Int J Nephrol 2019 12;2019:6265307. Epub 2019 Mar 12.

Mansoura Nephrology and Dialysis Unit, Internal Medicine Department, Mansoura University, Egypt.

Introduction: Postoperative acute kidney injury is associated with a higher mortality, a more complicated hospital course with longer hospital stay. Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery.

Methods: We evaluated 45 patients who underwent open heart surgery from January 2016 to June 2016. Read More

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http://dx.doi.org/10.1155/2019/6265307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434264PMC

Treatment of the extrahepatic manifestations of chronic hepatitis C infection.

Clin Liver Dis (Hoboken) 2018 May 5;11(5):115-118. Epub 2018 Jun 5.

Division of Gastroenterology Cape Fear Center for Digestive Diseases Fayetteville NC USA.

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http://dx.doi.org/10.1002/cld.705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385956PMC

RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin-proteasome pathway contributes to the reversion of ATRA resistance.

Cancer Cell Int 2019 4;19:84. Epub 2019 Apr 4.

1Department of Hematology, The Secong Xiangya Hospital, Central South University, Changsha, 410011 Hunan China.

Background: - is a newly identified fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive oncogene and is different from the classic - in terms of therapeutic reaction.

Methods: To reveal the functional characteristics and regulating mechanism of the - fusion gene, we established a --transfected HL60 cell model and examined its sensitivity to ATRA by western blot, MTT assay, flow cytometry, and Wright-Giemsa staining. Read More

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http://dx.doi.org/10.1186/s12935-019-0803-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449960PMC

Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis.

Drug Des Devel Ther 2019 28;13:999-1009. Epub 2019 Mar 28.

Department of Nephrology, The First Hospital of Jilin University, Changchun, China,

Background: The elevated calcium and phosphorus levels in patients undergoing hemodialysis may increase the risk of all-cause mortality. Paricalcitol, as a new vitamin D receptor activator (VDRA), seemed to be effective in reducing the calcium and phosphorus levels.

Objectives: The aim of this study was to compare the efficacy and safety of paricalcitol with other VDRAs in patients undergoing hemodialysis. Read More

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http://dx.doi.org/10.2147/DDDT.S176257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445244PMC

Cause, Consequence or confounding? The kidney in hypertension.

J Hum Hypertens 2019 Apr 16. Epub 2019 Apr 16.

Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1038/s41371-019-0199-6DOI Listing

SGLT2 inhibitor and incretin mimetic therapy for type 2 diabetes and chronic kidney disease.

Lancet Diabetes Endocrinol 2019 Apr 12. Epub 2019 Apr 12.

Providence Medical Research Center, Providence Health Care, Nephrology Division, Kidney Research Institute, and Institute of Translational Health Sciences, University of Washington, Spokane, WA 99204, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(19)30116-0DOI Listing

Albuminuria-lowering effect of dapagliflozin alone and in combination with saxagliptin and effect of dapagliflozin and saxagliptin on glycaemic control in patients with type 2 diabetes and chronic kidney disease (DELIGHT): a randomised, double-blind, placebo-controlled trial.

Lancet Diabetes Endocrinol 2019 Apr 12. Epub 2019 Apr 12.

Clinical Pharmacy and Pharmacology Department, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands. Electronic address:

Background: In patients with type 2 diabetes, intensive glucose control can be renoprotective and albuminuria-lowering treatments can slow the deterioration of kidney function. We assessed the albuminuria-lowering effect of the sodium-glucose co-transporter-2 inhibitor dapagliflozin with and without the dipeptidyl peptidase-4 inhibitor saxagliptin, and the effect of dapagliflozin-saxagliptin on glycaemic control in patients with type 2 diabetes and moderate-to-severe chronic kidney disease.

Methods: In this double-blind, placebo-controlled trial (DELIGHT), we enrolled patients at 116 research centres in Australia, Canada, Japan, South Korea, Mexico, South Africa, Spain, Taiwan, and the USA. Read More

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http://dx.doi.org/10.1016/S2213-8587(19)30086-5DOI Listing

Association between prediabetes (defined by HbA1, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study.

BMC Nephrol 2019 Apr 16;20(1):130. Epub 2019 Apr 16.

Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Dongil-ro 1342, Nowon-gu, Seoul, 01757, South Korea.

Background: The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study.

Methods: This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1 level. Read More

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http://dx.doi.org/10.1186/s12882-019-1307-0DOI Listing