126,967 results match your criteria Nephrology news & issues[Journal]


Idebenone and T2D: A new insulin-sensitizing drug for personalized therapy.

Pharmacol Res 2018 Dec 12. Epub 2018 Dec 12.

International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, "L. Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy; Transplantation Research Center, Nephrology Division, Brigham and Women's Hospital, Boston, MA, United States; Endocrinology Division, ASST Fatebenefratelli-Sacco, Milan, Italy. Electronic address:

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December 2018

Comparison of fatigue, pain and depression in patients with advanced kidney disease and cancer - symptom burden and clusters.

J Pain Symptom Manage 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA.

Context: While symptom clusters have been studied in the context of cancer, few data exist in chronic and end stage kidney disease (CKD/ESKD) patients.

Objectives: To (1) characterize and compare symptom cluster phenotypes in patients with advanced CKD, ESKD and cancer, and (2) explore predictors of symptom clusters.

Methods: We conducted secondary data analysis of three prospective studies in which pain, depression, and fatigue were assessed in patients with stage 4-5 CKD, ESKD and gastrointestinal (GI) cancer. Read More

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December 2018

Lower incidence of de novo donor-specific antibodies against HLA-DR in ABO-incompatible renal transplantation.

Hum Immunol 2018 Dec 12. Epub 2018 Dec 12.

Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Electronic address:

Recently, in vitro experiments have demonstrated that anti-blood group A/B antibody binding to endothelial cells induce a protective effect against antibody-mediated injury. This study aimed to clarify the potential clinical benefit of ABO incompatibility in donor-specific HLA antibody (DSA)-induced chronic antibody-mediated rejection (ABMR). We enrolled 215 ABO-incompatible renal transplant (ABO-I) and 467 ABO-identical/compatible renal transplant recipients (ABO-Id/C). Read More

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December 2018

Calcitriol loading before total parathyroidectomy with autotransplant in patients with end stage kidney disease: Does it prevent postoperative hypocalcaemia?

Intern Med J 2018 Dec 15. Epub 2018 Dec 15.

Endocrine and General Surgery, Department of Surgery, John Hunter Hospital and Newcastle Private Hospital, Lookout Road New Lambton Heights, New South Wales, Australia, 2305.

Background: Hungry bone syndrome (HBS) is one of the most serious complications following parathyroidectomy for severe hyperparathyroidism. There is a lack of literature informing the treatment and risk factors for this condition and the ideal pre-operative strategy for prevention.

Aims: The primary aims of this study were to examine the incidence of HBS with pre-operative calcitriol loading for 10 days and to determine the risk factors for HBS. Read More

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December 2018

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels.

Diabetes Obes Metab 2018 Dec 15. Epub 2018 Dec 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tuebingen, Tuebingen, Germany.

Aim: Pharmacologic administration of insulin as nasal spray in humans has demonstrated a modulation of endogenous glucose production via the brain when systemic insulin levels are high. Results are conflicting under fasting insulin concentrations. To evaluate effects of brain insulin on endogenous glucose production in fasting humans with focus on hepatic glucose release, we performed a randomized, placebo controlled, blinded, cross-over experiment. Read More

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December 2018
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Parents' experiences of donation to their child before kidney transplantation: A qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Institute, University of Southern, Denmark.

Aim And Objectives: To explore Parents' experiences of donation to their child before kidney transplantation.

Background: Transplantation is the treatment of choice for pediatric patients with end-stage renal disease. Living donor kidney transplantation has shown a higher long-term transplant survival compared to deceased donor transplantation and entails a more controllable process, with shorter waiting time. Read More

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December 2018

A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients.

Br J Clin Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Hospital Pharmacy, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Aims: The aims of this study were to describe the pharmacokinetics of tacrolimus immediately after kidney transplantation, and to develop a clinical tool for selecting the best starting dose for each patient.

Methods: Data on tacrolimus exposure were collected for the first three months following renal transplantation. A population pharmacokinetic analysis was conducted using nonlinear mixed-effects modeling (NONMEM). Read More

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December 2018

Pharmacokinetics of Prolonged-Release Once-Daily Formulations of Tacrolimus in De Novo Kidney Transplant Recipients: A Randomized, Parallel-Group, Open-Label, Multicenter Study.

Adv Ther 2018 Dec 14. Epub 2018 Dec 14.

Service de Néphrologie, Dialyse, Aphérèses et Transplantation, CHU Grenoble Alpes, Grenoble, France.

Introduction: Different prolonged-release formulations of tacrolimus are available. To date, the pharmacokinetic (PK) profile of LCP-tacrolimus (LCPT; Envarsus) has not been compared with PR-Tac (Advagraf) in de novo kidney transplant recipients. These profiles will guide clinical recommendations for the initiation and dose titration strategies of once-daily tacrolimus formulations. Read More

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December 2018

Growth plate alterations in chronic kidney disease.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More

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December 2018
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Five-year outcome of children with idiopathic nephrotic syndrome: the NEPHROVIR population-based cohort study.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric Nephrology, Hôpital Robert-Debré, APHP, 48 Bd Serurier, 75019, Paris, France.

Background: The optimal therapeutic regimen for children at onset of idiopathic nephrotic syndrome (INS) is still under debate. A better knowledge of the disease's course is necessary to design more appropriate and/or personalized treatment protocols.

Methods: We report the 5-year outcome of patients included from December 2007 to May 2010 in the prospective multicentric and multiethnic population-based NEPHROVIR study. Read More

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December 2018
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Generation by somatic cell nuclear transfer of GGTA1 knockout pigs expressing soluble human TNFRI-Fc and human HO-1.

Transgenic Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.

Herein, we successfully generated transgenic pigs expressing both soluble human tumor necrosis factor receptor I IgG-Fc (shTNFRI-Fc) and human hemagglutinin (HA)-tagged-human heme oxygenase-1 (hHO-1) without Gal epitope. Healthy cloned pigs were produced by somatic cell nuclear transfer (SCNT) using the genetically modified cells. The genetic disruption of the GGTA1 genes and absence of expression of BS-IB4 lectin in tail-derived fibroblast of the SCNT-generated piglets were successfully confirmed. Read More

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December 2018

Juvenile dermatomyositis with IgA nephropathy: case-based review.

Rheumatol Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. Read More

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December 2018
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Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

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December 2018

A CD4 T cell population provides B cell help in SLE.

Authors:
Susan J Allison

Nat Rev Rheumatol 2018 Dec 14. Epub 2018 Dec 14.

Nature Reviews Nephrology, .

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December 2018

Anticoagulation in patients with concomitant lupus nephritis and thrombotic microangiopathy: a multicentre cohort study.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

Center of Research of Immunopathology and Rare Diseases- Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.

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December 2018

Smaller erector spinae muscle size is associated with inability to recover activities of daily living after pneumonia treatment.

Respir Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. Electronic address:

Background: Elderly patients who are hospitalized due to pneumonia experience deterioration of their activities of daily living (ADL) during this period; in some cases, this loss of ADL is not recovered at the end of antibiotic treatment. In this study, we examined whether erector spinae muscle cross-sectional area (ESMCSA) measured by computed tomography (CT) could predict a low level of ADL at the end of antibiotic treatment for pneumonia.

Methods: Eighty patients (mean age 74. Read More

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December 2018

HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.

Kidney Int 2018 Dec 7. Epub 2018 Dec 7.

Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu. Electronic address:

Hypoxia promotes tubulointerstitial inflammation in the kidney. Although hypoxia inducible factor-1α (HIF-1α) is a master regulator of the response to hypoxia, the exact mechanisms through which HIF-1α modulates the induction of tubulointerstitial inflammation are still largely unclear. We demonstrated tubulointerstitial inflammation and increased tubular HIF-1α expression in murine models of ischemia/reperfusion injury and unilateral ureteral obstruction. Read More

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December 2018

Can immune biomarkers predict infections in solid organ transplant recipients? A review of current evidence.

Transplant Rev (Orlando) 2018 Oct 9. Epub 2018 Oct 9.

Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Australia; Department of Nephrology, Monash Medical Centre, Clayton, Victoria 3168, Australia. Electronic address:

Despite improvements in graft survival, solid organ transplantation is still associated with considerable infection induced morbidity and mortality. If we were able to show that serious infection risk was associated with excessive suppression of immune capacity, we would be justified in "personalizing" the extent of immunosuppression by carefully monitored reduction to see if we can improve immune compromize without increasing the risk of rejection. Reliable biomarkers are needed to identify this patients at an increased risk of infection. Read More

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October 2018

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Biochemistry, College of Medicine, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea.

Alzheimer's disease (AD) is a neurodegenerative disease, which is accompanied by memory loss and cognitive dysfunction. Although a number of trials to treat AD are in progress, there are no drugs available that inhibit the progression of AD. As the aggregation of amyloid-β (Aβ) peptides in the brain is considered to be the major pathology of AD, inhibition of Aβ aggregation could be an effective strategy for AD treatment. Read More

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December 2018
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Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo.

Biomed Pharmacother 2019 Jan 30;109:2375-2386. Epub 2018 Nov 30.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

Triptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP has also been shown to act directly on immortalized podocytes in culture to protect them from injury. In the present study, we examined the effect of TP on healthy podocytes both in vitro and in vivo to better understand the action of TP on podocytes. Read More

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January 2019

Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway.

Biomed Pharmacother 2019 Jan 29;109:2309-2317. Epub 2018 Nov 29.

College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118 China. Electronic address:

Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of cancers. Nephrotoxicity induced by cisplatin seriously limits its clinical application. Icariin, a major and remarkable flavonoid isolated from Epimedium koreanum, has been reported to exert anti-oxidative stress and anti-inflammation actions. Read More

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January 2019
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Pterostilbene, a bioactive component of blueberries, alleviates renal fibrosis in a severe mouse model of hyperuricemic nephropathy.

Biomed Pharmacother 2019 Jan 26;109:1802-1808. Epub 2018 Nov 26.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Accumulating evidences indicated that hyperuricemia was an independent risk factor for kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases. In the study, pterostilbene (PTE) as a bioactive component of blueberries was confirmed to possess lowering serum uric acid and renal protective functions by the decrease of serum creatinine, BUN, urine albumin, and urine albumin-to-creatinine ratio (uACR) in a mouse model of hyperuricemic nephropathy (HN). Read More

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January 2019

SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2.

Biomed Pharmacother 2019 Jan 9;109:1327-1338. Epub 2018 Nov 9.

Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. Electronic address:

Background: Sodium glucose cotransporter-2 (SGLT-2) inhibitors have been widely used in the clinic to reduce blood glucose levels by enhancing glucose excretion. However, whether such agents might also reduce glucose absorption via the peritoneal function of human peritoneal mesothelial cells (HPMCs) that also express SGLT-2 is not clear.

Methods: An acute peritoneal dialysis (PD) model in nonuremic rats was established. Read More

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January 2019

In Patients with Chronic Kidney Disease, There Is No Such Thing as 'Stable'.

Authors:
Candice Halinski

Nephrol Nurs J 2016 Sep-Oct;43(5):445-446

Director, Service Line-Clinical, Division of Nephrology, Northwell Health, Manhasset, NY.

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December 2018

Peritoneal Dialysis Catheter Obstruction by Uterine Tubaric Fimbriae in an Adult Woman with Developmental Abnormalities.

Nephrol Nurs J 2016 Sep-Oct;43(5):439-441

Professor of Nephrology, University of Pavia, Chief of Unit of Nephrology, Dialysis and Transplant, Fondazione IRCCS Policlinico, San Matteo, Pavia. Italy.

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December 2018
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What Are Ethical Issues When Honoring an Older Adult's Decision to Withdraw from Dialysis?

Nephrol Nurs J 2016 Sep-Oct;43(5):429-450

Nephrologist, Cleveland Clinic Florida, Department of Nephrology and Hypertension, Weston, FL.

Over the next decade, nephrology nurses will witness a continual growth of older adults undergoing hemodialysis. At some point after initiating dialysis, some people will request withdrawal from dialysis, which can present ethical challenges for nurses as they engage in shared decision-making with the patient, family, and other healthcare professionals. This article presents an older adult's story from initiation of dialysis to withdrawal from dialysis and discusses an approach to address ethical issues related to withdrawal from dialysis. Read More

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December 2018

Determining Nurse Staffing for Peritoneal Dialysis Care.

Nephrol Nurs J 2016 Sep-Oct;43(5):XXX

Renal Nurse, Hospital São Lucas da PUC Porto Alegre, Brazil.

There is no consensus on the ideal staffing levels for peritoneal dialysis (PD) units. The objective of this two-phase study was to evaluate nurse staffing levels in a PD unit based on activities and time spent performing them. An instrument was created based on nursing activities identified by a focus group, and the time spent performing these activities was measured over a four-month period. Read More

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December 2018

Patient Handoffs in Nephrology Nurse Practice Settings: A Safety Study.

Nephrol Nurs J 2016 Sep-Oct;43(5):379-400

Assistant Professor, Bloomsburg University, Bloomsburg, PA.

Research investigating patient handoff processes has inundated the safety literature, but not in nephrology nurse practice settings. Effective patient handoffs are essential for maintaining patient safety by avoiding errors related to poor information exchange. This mixed methods research study investigated the process of patient handoff across nephrology practice settings and the implications for patient safety and nursing practice. Read More

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December 2018

The Role of the Cytochrome P450 System in Vulnerable Patients: An Opportunity to Improve Outcomes.

Nephrol Nurs J 2016 Jul-Aug;43(4):347-350

Professor of Clinical and Associate Dean for Health Studies, School of Nursing and Health Studies, University of Miami, Coral Gables, FL.

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December 2018

Patient Handoffs: What They Are and How They Contribute to Patient Safety.

Authors:
Tamara M Kear

Nephrol Nurs J 2016 Jul-Aug;43(4):339-342

Assistant Professor of Nursing, Villanova University, Villanova, PA.

Communication and patient handoffs during transitions in care have been increasingly investigated due to their relationships with patient safety, quality of care, and efficiency. Handoffs occur at two points in the delivery of nursing care: nurse transitions in care and patient transitions in care. This article explores the accepted definitions, best practices, and evidence related to patient handoffs and patient safety. Read More

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December 2018

Attitudes of Nephrology Nurses Toward Patient Exercise During Hemodialysis.

Nephrol Nurs J 2016 Jul-Aug;43(4):331-337

Senior Research Fellow at Eastern Health-Deakin University Nursing and Midwifery Research Centre, Victoria, Australia.

Exercise programs are rare in hemodialysis clinics. The study goals were to 1) explore nephrology nurses' attitudes toward exercise; 2) compare the attitudes between nephrology nurses who had been exposed and those who had not been exposed to an patient exercise program; and 3) measure the psychometric properties of a survey tool to measure nephrology nurses' attitudes toward intradialytic exercise. Nephrology nurse attitudes were positive toward patients' exercising; however, they did not believe it was their responsibility to conduct the exercise program. Read More

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December 2018

Exercise and Hemodialysis: The Missing Piece of Tertiary Prevention.

Authors:
Mary Hannan

Nephrol Nurs J 2016 Jul-Aug;43(4):317-321

Beginning a nursing PhD program at the University of Illinois-Chicago, Chicago, IL.

Exercise is an important element of preventative health, but it is not commonly practiced by patients on hemodialysis. This article summarizes the research on potential physiologic and psychological benefits of exercise for patients on hemodialysis and discusses recommendations of how exercise counseling can be conducted by nephrology nurses. Read More

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December 2018

Nephrology Nursing in Rwanda: Creating the Future Through Education and Organizational Partnership.

Nephrol Nurs J 2016 Jul-Aug;43(4):311-315

Visiting Faculty at University of Rwanda and ICU Clinical Educator at Rwanda Military Hospital, Human Resources for Health Program in partnership with the New York University Rory Meyers College of Nursing.

The Human Resources for Health Program was launched in Rwanda in 2012 as a sevenyear initiative to improve healthcare services and decrease overall dependence on foreign aid. In partnership between U.S. Read More

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December 2018

Nephrology Nursing: Be All That You Can Be.

Nephrol Nurs J 2016 Jul-Aug;43(4):283-329

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December 2018

Uromodulin in a pathway between decreased renal urate excretion and albuminuria.

Am J Hypertens 2018 Dec 14. Epub 2018 Dec 14.

Centre de recherche du CHUM, Montréal, Quebec, Canada.

Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e. Read More

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December 2018

Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome.

Rheumatology (Oxford) 2019 Jan;58(1):103-109

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.

Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More

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January 2019

Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia.

Cell Signal 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Chronic kidney disease (CKD) is a global health problem with a profound impact on quality of life. Cardiovascular disease is established as a major cause of morbidity and mortality in patients with CKD. Dyslipidemia is frequently observed in CKD patients, suggesting a causal relation between dyslipidemia and cardiovascular disease in CKD patients. Read More

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December 2018

Improving Patient Experience and Treatment Adherence in the Adult, Outpatient Hemodialysis Population.

J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.

Valley Nephrology Associates, Roanoke, Virginia (Drs Saunders and Ahmadzadeh and Ms Wright); Duke University School of Nursing, Durham, North Carolina (Drs Bush and Granger); and Duke Heart Center Nursing Research Program, Durham, North Carolina (Dr Granger).

Background: The commonly employed medication reconciliation process leaves room for mismanagement of medications in the complex end-stage renal disease patient population.

Purpose: The purpose of this quality improvement project was to implement and evaluate a multidisciplinary education and feedback intervention designed to improve self-management for adults with end-stage renal disease.

Methods: A pre-post, same subject repeated measures design was used to evaluate the intervention. Read More

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December 2018

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland.

Pol J Microbiol 2018 ;67(4):517-524

Chair and Department of Nephrology, Jagiellonian University , Cracow , Poland.

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli ( E. coli ) as the main etiological factor in different age groups. Read More

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January 2018

[The pathway of vasopressin as a pharmacological target in nephrology: a narrative review].

G Ital Nefrol 2018 Dec;35(6)

U.O.C. Nefrologia, Università cattolica del sacro cuore. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. Read More

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December 2018

[Methodology for determining workforce in health nephrologic unit in ITALY. Update of lows].

G Ital Nefrol 2018 Dec;35(6)

Membro del Direttivo SIN, esperto di organizzazione sanitaria, ex responsabile controllo di gestione ospedale di Perugia, ex coordinatore governo clinico SIN.

Nephrology continues to be in transition. While rates of kidney diseases and injury continue to rise, changes in the general health care system and the delivery of kidney care make it unclear how increases in need will be translated into demand for nephrologists. The changes in the delivery system also raise questions as to the future roles and career paths for nephrologists. Read More

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December 2018

Assessing extracellular volume excess in dialysis patients.

Ther Apher Dial 2018 Dec 13. Epub 2018 Dec 13.

Medical Services, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.

We read the recent article by Yoowannakul et al. [1] with great interest but we are at disagreement with some of their approach and conclusions. The Authors "found no association between overhydration and right ventricular volumes" using bioimpedance with the cardiac MRI, while they also "found that NT pro-BNP …was associated with left sided cardiac chamber sizes… but not right ventricular dimensions, which would suggest that NT-pro-BNP does not reflect plasma volume". Read More

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December 2018

Low copeptin levels in patients with intradialytic hypotension.

Ther Apher Dial 2018 Dec 14. Epub 2018 Dec 14.

Gazi University Faculty of Medicine, Department of Nephrology, Ankara, Turkey.

Background: Intradialytic hypotension (IDH) is related with high morbidity and mortality. There is evidence that arginine-vasopressin (AVP) responses could play a role. Copeptin is the reliable biomarker of AVP. Read More

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December 2018

Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

Pustulotic arthro-osteitis, occasionally complicated with palmoplantar pustulosis, affects patients' activities of daily living. Granulocyte and monocyte adsorption apheresis selectively removes activated granulocytes and monocytes by means of extracorporeal circulation. Although the efficacy of granulocyte and monocyte adsorption apheresis in the treatment of generalized pustular psoriasis has been proved, very few reports have assessed its efficacy in the treatment of palmoplantar pustulosis and pustulotic arthro-osteitis. Read More

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December 2018
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LncRNA NEAT1 promotes extracellular matrix accumulation and epithelial-to-mesenchymal transition by targeting miR-27b-3p and ZEB1 in diabetic nephropathy.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People's Republic of China.

Diabetic nephropathy (DN) is a kind of microvascular complications of diabetes. Long noncoding RNAs (lnRNAs) can participate in the development of various diseases, including DN. However, the function of lncRNA NEAT1 is unclear. Read More

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December 2018

Outcome of Sirolimus based Immunosuppression, Fifteen Years Post Live-Donor Kidney Transplantation: Single Center Experience.

Clin Transplant 2018 Dec 13:e13463. Epub 2018 Dec 13.

Urology and Nephrology Center, Nephrology division, Mansoura University, Egypt.

In a prospective randomized controlled trial, between May 2001 and January 2003, 132 live donor kidney transplant recipients were randomized to receive sirolimus primary immunosuppression, either in combination with low dose tacrolimus (TAC group) or in combination with mycophenolate mofetil (MMF group). We have previously reported on two and five year- follow up results, with favorable patient and graft outcomes obtained in both groups. In view of recent published reports of increased risk of inferior outcomes among sirolimus- treated patients, we herein present results of an observational extension of the previously randomized patients 15 years post -transplantation. Read More

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December 2018

Late CMV infections after kidney transplantation under the preemptive strategy: risk factors and clinical aspects.

Transpl Infect Dis 2018 Dec 13:e13035. Epub 2018 Dec 13.

Division of Infectious Diseases, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil.

Background: Late CMV infections (LCMV) after the cessation of prophylaxis are well described. We aimed to assess clinical and epidemiological data on late occurring CMV infections in the absence of CMV prophylaxis in a cohort of kidney transplant patients.

Methods: In a cohort of kidney transplant recipients not employing CMV specific prophylaxis, patients with CMV infections occurring after the six month of transplantation were compared to patients with CMV infections diagnosed within the first six months (early infections). Read More

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December 2018

Optimizing the Clinical Utility of Sirolimus-Based Immunosuppression for Kidney Transplantation.

Clin Transplant 2018 Dec 13:e13464. Epub 2018 Dec 13.

Clínica Universitaria Colombia, Fundacion Universitária de Ciencias de la Salud, Bogotá, Colombia.

While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long-term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection-associated death. Immunosuppression strategies are needed to balance risks of acute and subclinical rejection with long-term benefits of improved kidney function. Sirolimus, an inhibitor of mammalian target of rapamycin, is used for immunosuppression in kidney transplantation. Read More

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December 2018

Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds.

Macromol Biosci 2018 Dec 13:e1800412. Epub 2018 Dec 13.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99,, 3584, CG Utrecht, The Netherlands.

The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on active tubular secretion. Biofabricated tissues could make a valuable contribution, but kidneys are highly intricate and multifunctional organs. Read More

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December 2018