129,172 results match your criteria Nephrology dialysis transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association[Journal]


Liver transplant, toxoplasmosis and kidney stones: connecting the dots.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Nephrology, University of Florida College of Medicine, Gainesville, Florida, USA.

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http://dx.doi.org/10.1136/bcr-2019-229197DOI Listing
February 2019

In vitro osteogenic differentiation potential of the human induced pluripotent stem cells augment when grown on graphene oxide-modified nanofibers.

Gene 2019 Feb 14. Epub 2019 Feb 14.

Department of Tissue engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Due to the several limitations that surgeons are faced during bone tissue implantation there are daily increases in introducing new cell-co-polymer composites for use in bone tissue engineering approaches. In this study tried to develop a suitable nanostructured bio-composite for enhancing osteogenic differentiation of the human induced pluripotent stem cells (iPSCs). Polyvinylidene fluoride-Graphene oxide (PVDF-GO) nanofibers was fabricated by electrospinning and then characterized using scanning electron microscope, tensile and viability assays. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.028DOI Listing
February 2019

Five-year outcomes after first- and second-generation drug-eluting stent implantation in all patients undergoing percutaneous coronary intervention.

J Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan.

Background: Use of the everolimus-eluting stent (EES) instead of the sirolimus-eluting stent (SES) has been shown to improve clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) out to 3 years. However, it is not known whether the differences in efficacy and safety outcomes remain constant throughout 5 years.

Methods: This was a retrospective, non-randomized, observational study. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.01.012DOI Listing
February 2019

Circulating CD14CD163CD209 M2-like monocytes are associated with the severity of infection in Helicobacter pylori-positive patients.

Mol Immunol 2019 Feb 13;108:13-22. Epub 2019 Feb 13.

Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun 130021, China; Key Laboratory of Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun 130021, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China. Electronic address:

Helicobacter pylori (H. pylori) initiates a robust host immune response and subsequently results in chronic inflammation in the gastric mucosa. This study monitored the circulating monocyte subsets and measured the plasma levels of IL-10 and IL-12 in response to H. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.017DOI Listing
February 2019

The detection of BKPyV genotypes II and IV after renal transplantation as a simple tool for risk assessment for PyVAN and transplant outcome already at early stages of BKPyV reactivation.

J Clin Virol 2019 Feb 10;113:14-19. Epub 2019 Feb 10.

Institute for Virology, University Hospital Essen, University of Duisburg-Essen Virchowstr. 179, 45147, Essen, Germany.

Background: After reactivation the BK-polyomavirus (BKPyV) associated nephropathy (PyVAN) is observed in 1-10% of renal transplant recipients, of which up to 80% undergo graft failure. BKPyV reactivation after renal transplantation was associated with donor-derived serotypes against which the recipient has no immunological protection. However, PyVAN risk assessment seroactivity testing is a time-consuming and cost intensive process. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.02.002DOI Listing
February 2019

Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells.

Biol Chem 2018 Dec 1. Epub 2018 Dec 1.

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, 601 Huangpu Avenue West, Guangzhou510632,China.

Gelsolin (GSN) is an actin filament-capping protein that plays a key role in cell migration. Here we showed that heterogeneous nuclear ribonucleoprotein K (hnRNPK) regulates GSN expression level by binding to the 3'-untranslated region (3'UTR) of GSN mRNA in non-small cell lung cancers (NSCLC) H1299 cells which are highly metastatic and express high level of GSN. We found that hnRNPK overexpression increased the mRNA and protein level of GSN, whereas hnRNPK knockdown by siRNA decreased the mRNA and protein level of GSN in both H1299 and A549 cells, indicating a positive role of hnRNPK in the regulation of GSN expression. Read More

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http://dx.doi.org/10.1515/hsz-2018-0417DOI Listing
December 2018

The skewed frequency of B-cell subpopulation CD19 CD24 CD38 cells in peripheral blood mononuclear cells is correlated with the elevated serum sCD40L in patients with active systemic lupus erythematosus.

J Cell Biochem 2019 Feb 16. Epub 2019 Feb 16.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

CD19 CD24 CD38 cells play an essential role in maintaining immune homeostasis. CD40 signaling is involved in regulating the induction and function of CD19 CD24 CD38 cells. Changes in B-cell subpopulations and CD19 CD24 CD38 cells have been observed in systemic lupus erythematosus (SLE) patients. Read More

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http://dx.doi.org/10.1002/jcb.28427DOI Listing
February 2019

PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.

J Physiol 2019 Feb 16. Epub 2019 Feb 16.

Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University, Columbus, OH, 43210.

Key Points Summary: Small-conductance Ca -activated K (SK) channels expressed in ventricular myocytes are dormant in health yet become functional in cardiac disease. SK channels are voltage independent and their gating is controlled by intracellular [Ca ] in a biphasic manner. Submicromolar [Ca ] activates the channel via constitutively-bound calmodulin, while higher [Ca ] exerts inhibitory effect during depolarization. Read More

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http://dx.doi.org/10.1113/JP277618DOI Listing
February 2019

Diabetes Management in Older Adults With Chronic Kidney Disease.

Curr Diab Rep 2019 Feb 15;19(3):11. Epub 2019 Feb 15.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose Of Review: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.

Recent Findings: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. Read More

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http://dx.doi.org/10.1007/s11892-019-1128-3DOI Listing
February 2019

Cyclin G1 drives maladaptive renal repair.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0124-9DOI Listing
February 2019

Characteristics of visit-to-visit blood pressure variability in hemodialysis patients.

Hypertens Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.

Visit-to-visit blood pressure variability (VVBPV) is an independent risk factor for cardiovascular morbidity and mortality in the general population. Hemodialysis (HD) patients have a poor prognosis due to an increased prevalence of cardiovascular disease. Intradialytic hypotension is associated with excess mortality, but whether VVBPV influences mortality is still unclear in HD patients. Read More

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http://dx.doi.org/10.1038/s41440-019-0231-9DOI Listing
February 2019

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling.

Exp Mol Med 2019 Feb 15;51(2):18. Epub 2019 Feb 15.

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. Read More

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http://dx.doi.org/10.1038/s12276-019-0217-3DOI Listing
February 2019

Potential pathological role of pro-inflammatory cytokines (IL-6, TNF-α, and IL-17) in xenotransplantation.

Xenotransplantation 2019 Feb 16:e12502. Epub 2019 Feb 16.

Department of Nephrology, Shenzhen Longhua District Central Hospital, Guangdong Medical University Affiliated Longhua District Central Hospital, Shenzhen, China.

The major limitation of organ transplantation is the shortage of available organs from deceased human donors which leads to the deaths of thousands of patients each year. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection and coagulation dysfunction are two major hurdles for the successful survival of pig xenografts in primate recipients. Read More

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http://dx.doi.org/10.1111/xen.12502DOI Listing
February 2019

Clinical Characteristics of Patients with Spondyloarthritis in Japan in Comparison with Other Regions of the World.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

From the Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; Institute of Rheumatology, Tokyo Women's Medical University; Department of Orthopedic Surgery, Juntendo University School of Medicine; Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine, Tokyo; Department of Orthopedic Surgery, Shiga University of Medical Science, Shiga; Department of Rheumatology, Tonan Hospital, Hokkaido; Department of Orthopedic Surgery, Fujita Health University, Aichi; Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo; Department of Rheumatology, Chubu Rosai Hospital, Aichi; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi; Department of Orthopedics, Osaka Minami Medical Center, Osaka; Department of Rheumatology, Daido Hospital, Aichi; Department of Internal Medicine, Juntendo University Koshigaya Hospital, Saitama; Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine, Osaka, Japan; departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Division of Rheumatology, National University Hospital, Singapore; Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University, Tao-Yuan, Taiwan; Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba, Córdoba, Spain; Department of Rheumatology, Paris Descartes University, Cochin Hospital, Paris, France; INSERM Unit 1183, CRESS, Paris, France; Department of Rheumatology, Leiden University Medical Center, Leiden, the Netherlands. This study was conducted under the umbrella of the International Society for Spondyloarthritis Assessment (ASAS) and the COMOSPA study was supported by the unrestricted grants from Pfizer, AbbVie, and UCB. M.K. received honoraria from AbbVie and Ayumi; K.Y. receives tuition support from Harvard T.H. Chan School of Public Health (partially supported by training grants from Pfizer, Takeda, Bayer, and PhRMA); A.M. has received research grants from Abbvie, Pfizer, and MSD. M. Kishimoto, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Yoshida, MD, MPH, ScD, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health; N. Ichikawa, MD, Institute of Rheumatology, Tokyo Women's Medical University; H. Inoue, MD, Department of Orthopedic Surgery, Juntendo University School of Medicine; Y. Kaneko, MD, Division of Rheumatology, Department of Rheumatology, Keio University School of Medicine; T. Kawasaki, MD, Department of Orthopedic Surgery, Shiga University of Medical Science; K. Matsui, MD, Department of Rheumatology, Tonan Hospital, M. Morita, MD, Department of Orthopedic Surgery, Fujita Health University; M. Suda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; K. Tada, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; N. Takizawa, MD, Department of Rheumatology, Chubu Rosai Hospital; N. Tamura, MD, Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine; A. Taniguchi, MD, Institute of Rheumatology, Tokyo Women's Medical University; Y. Taniguchi, MD, Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School; S. Tsuji, MD, Department of Orthopedics, Osaka Minami Medical Center; Y. Haji, MD, Department of Rheumatology, Daido Hospital; R. Rokutanda, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; H. Yanaoka, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; P.P. Cheung, MD, Division of Rheumatology, National University Hospital; J. Gu, MD, Division of Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University; T.H. Kim, MD, Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases; S.F. Luo, MD, Department of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital and Chang Gung University; M. Okada, MD, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University; C. López Medina, MD, Hospital Universitario Reina Sofía/IMIBIC/University of Córdoba; A. Molto, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; M. Dougados, MD, Department of Rheumatology, Paris Descartes University, Cochin Hospital, and INSERM Unit 1183, CRESS; S. Kobayashi, MD, PhD, Department of Internal Medicine, Juntendo University Koshigaya Hospital; D. van der Heijde, MD, Department of Rheumatology, Leiden University Medical Center; T. Tomita, MD, Department of Orthopedic Biomaterial Science, Osaka University Graduate School of Medicine. Address correspondence to Dr. M. Kishimoto, Immuno-Rheumatology Center, St. Luke's International Hospital, St. Luke's International University, 9-1 Akashicho, Chuo-ku, Tokyo, Japan, 104-8560. E-mail: Accepted for publication October 11, 2018.

Objective: To delineate clinical characteristics of patients with spondyloarthritis (SpA) in Japan in comparison to other areas of the world.

Methods: Using the ASAS-COMOSPA (Assessment of Spondyloarthritis international Society-COMOrbidities in SPondyloArthritis) data, an international cross-sectional observational study of patients with SpA, we analyzed information on demographics, disease characteristics, comorbidities, and risk factors. Patients were classified by region: Japan, other Asian countries (China, Singapore, South Korea, Taiwan), and non-Asian countries (Europe, the Americas, Africa). Read More

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http://dx.doi.org/10.3899/jrheum.180412DOI Listing
February 2019

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510005, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative stress has long been thought to play a role in triggering podocyte damage; however, the underlying mechanism remains poorly understood. Here we show that the Wnt/β-catenin pathway is involved in mediating oxidative stress-induced podocyte dysfunction. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.032DOI Listing
February 2019

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Kidney Int 2019 Feb 8. Epub 2019 Feb 8.

State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address:

In type 2 cardiorenal syndrome, chronic heart failure is thought to cause or promote chronic kidney disease; however, the underlying mechanisms remain poorly understood. We investigated the role of Wnt signaling in heart and kidney injury in a mouse model of cardiac hypertrophy and heart failure induced by transverse aortic constriction (TAC). At 8 weeks after TAC, cardiac hypertrophy, inflammation, and fibrosis were prominent, and echocardiography confirmed impaired cardiac function. Read More

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http://dx.doi.org/10.1016/j.kint.2018.11.021DOI Listing
February 2019

A Modern Primer on Light Chain Amyloidosis in 592 Patients With Mass Spectrometry-Verified Typing.

Mayo Clin Proc 2019 Feb 13. Epub 2019 Feb 13.

Division of Hematology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To describe the clinical and laboratory characteristics of patients with meticulously typed light chain (AL) amyloidosis.

Patients And Methods: Patients (N=592) with biopsy-proven, mass spectrometry-confirmed AL amyloidosis diagnosed from January 1, 2008, through August 31, 2015, were included.

Results: The median patient age at diagnosis was 63 years. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.08.006DOI Listing
February 2019

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Br J Anaesth 2019 Mar 28;122(3):350-360. Epub 2018 Dec 28.

Department of Physiology and Pharmacology, Stockholm, Sweden; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA; Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA. Electronic address:

Background: Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effects of MaR1 on postoperative neuroinflammation, macrophage activity, and cognitive function in mice. Read More

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http://dx.doi.org/10.1016/j.bja.2018.10.062DOI Listing

The Prognostic Significance of Puncture Timing to Survival of Arteriovenous Fistulas in Hemodialysis Patients: A Multicenter Retrospective Cohort Study.

J Clin Med 2019 Feb 15;8(2). Epub 2019 Feb 15.

Department of Nephrology, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.

(1) Background: A functional shunt is critical to hemodialysis, but the ideal timing of shunt cannulation is still not established. In this study, we assessed the association between ideal puncture timing and shunt survival. (2) Methods: This retrospective cohort study using data from the Taiwan Health and Welfare database, which included 26885 hemodialysis patients with arteriovenous fistulas from 1 July 2008 to 30 June 2012. Read More

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http://dx.doi.org/10.3390/jcm8020247DOI Listing
February 2019

The impact of interventions by pharmacists collected in a computerised physician order entry context: a prospective observational study with a 10-year reassessment.

Swiss Med Wkly 2019 Feb 15;149:w20015. Epub 2019 Feb 15.

Pharmacy Department, Georges-Pompidou European Hospital, APHP, Paris, France / Equipe 22, Centre de Recherche des Cordeliers, UMR, INSERM, Paris, France.

Aims Of The Study: This study assesses clinical interventions by pharmacists prospectively collected from medical and surgical wards, notably the acceptance of interventions, computerised physician order entry (CPOE)related problems, the potential impact of interventions on patient safety evaluated by a multidisciplinary committee, and their evolution over the 10 years since a first assessment.

Methods: A prospective observational study covering 13 months was conducted in a French teaching hospital with a patient information system that integrates an electronic health record (EHR) with a CPOE. Interventions by pharmacists were prospectively recorded using CPOE. Read More

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http://dx.doi.org/10.4414/smw.2019.20015DOI Listing
February 2019

The effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support.

J Crit Care 2019 Feb 5;51:71-76. Epub 2019 Feb 5.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:

Purpose: To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH).

Material And Methods: After intravenous infusion of 1 g meropenem over 3 h repeated every 8 h for at least 3 doses, 2 serial blood and ultrafiltration fluid samples were collected: one over a dose interval of meropenem with DHP-PMX therapy; and the other on the following day over a dose interval of meropenem with no DHP-PMX therapy. Meropenem concentrations were measured by high performance liquid chromatography. Read More

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http://dx.doi.org/10.1016/j.jcrc.2019.02.007DOI Listing
February 2019

Pharmacological urate-lowering approaches in chronic kidney disease.

Eur J Med Chem 2019 Jan 23;166:186-196. Epub 2019 Jan 23.

Kidney Research Laboratory, Division of Nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Chronic kidney disease (CKD) has become a global public health issue and uric acid (UA) remains a major risk factor of CKD. As the main organ for the elimination of UA, kidney owned a group of urate transporters in tubular epithelium. Kidney disease hampered the UA excretion, and the accumulation of serum UA in return harmed the renal function. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.043DOI Listing
January 2019

Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Increasing of the interferon-γ gene expression during polyomavirus BK infection in kidney transplant patients.

Microb Pathog 2019 Feb 12. Epub 2019 Feb 12.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Polyomavirus BK infection is a common complication and a major cause of morbidity after kidney transplantation. Surveillance of kidney transplant recipients was threatened by reactivation of polyomavirus BK infection can lead to polyomavirus BK-associated nephropathy (PVN). Antiviral immunoregulatory markers like Gamma interferon (IFN-γ) might also affect the polyomavirus BK pathogenesis for its role in antiviral host defense, graft rejection, and regulative of the adaptive immune responses. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.015DOI Listing
February 2019

Identification of microRNA-mRNA networks involved in cisplatin-induced renal tubular epithelial cells injury.

Eur J Pharmacol 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, 100730, China. Electronic address:

Cisplatin is a widely used chemotherapeutic drug that often causes acute kidney injury (AKI) in cancer patients. The contribution of miRNAs to the cisplatin-induced renal tubular epithelial cell injury remains largely unknown. Here we performed an integrative network analysis of miRNA and mRNA expression profiles to shed light into the underlying mechanism of cisplatin-induced renal tubular epithelial cell injury. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.015DOI Listing
February 2019
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Donor organ intervention before kidney transplantation: Head-to-head comparison of therapeutic hypothermia, machine perfusion, and donor dopamine pretreatment. What is the evidence?

Am J Transplant 2018 Jul 31. Epub 2018 Jul 31.

Department of Immunology, University of Heidelberg, Germany.

Therapeutic hypothermia, hypothermic pulsatile machine perfusion (MP), and renal-dose dopamine administered to stable brain-dead donors have shown efficacy to reduce the dialysis requirement after kidney transplantation. In a head-to-head comparison of the three major randomized controlled trials in this field, we estimated the number-needed-to-treat for each method, evaluated costs and inquired into special features regarding long-term outcomes. The MP and hypothermia trials used any dialysis requirement during the first post-operative week, while the dopamine trial assessed >1 dialysis session as primary endpoint. Read More

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http://dx.doi.org/10.1111/ajt.15317DOI Listing

A Prospective Multi-Center Observational Study of Cell-Mediated Immunity as a Predictor for Cytomegalovirus Infection in Kidney Transplant Recipients.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, United States.

T-cell immunity is essential for the control of cytomegalovirus (CMV) infection post-transplant. We evaluated a CMV-specific peptide-based ELISPOT assay to determine whether assay results could predict subsequent CMV events. Adult kidney transplant recipients at 43 centers underwent ELISPOT testing to enumerate IFN-γ binding spot forming units (sfu) after stimulation of cells with an overlapping peptide pool of CMV pp65 and IE-1 proteins at the end of antiviral prophylaxis (EOP) and various timepoints thereafter. Read More

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http://dx.doi.org/10.1111/ajt.15315DOI Listing
February 2019

Modelling Graft Loss in Patients with Donor-Specific Antibody at Baseline using the Birmingham-Mayo (BirMay) Predictor: Implications for Clinical Trials.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN.

Predicting which renal allografts will fail and the likely cause of failure is important in clinical trial design to either enrich patient populations to be or as surrogate efficacy endpoints for trials aimed at improving long-term graft survival. This study tests our previously Birmingham-Mayo model (termed the BirMay Predictor) developed in a low-risk kidney transplant population in order to predict the outcome of patients with DSA at the time of transplantation and identify new factors to improve graft loss prediction in DSA+ patients. We wanted define ways to enrich the population for future therapeutic intervention trials. Read More

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http://dx.doi.org/10.1111/ajt.15312DOI Listing
February 2019

Single cell immune profiling in transplantation research.

Am J Transplant 2019 Feb 15. Epub 2019 Feb 15.

Stanford University, Department of Medicine/Nephrology, Palo Alto, CA, 94305.

Recently developed single-cell profiling technologies hold promise to provide new insights including analysis of population heterogeneity and linkage of antigen receptors with gene expression. These technologies produce complex data sets that require knowledge of bioinformatics for appropriate analysis. In this minireview, we discuss several single-cell immune profiling technologies for gene and protein expression, including cytometry by time-of-flight, RNA sequencing, and antigen receptor sequencing, as well as key considerations for analysis that apply to each. Read More

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http://dx.doi.org/10.1111/ajt.15316DOI Listing
February 2019

Single nucleotide polymorphisms in renal transplantation: Can't see the wood for the trees.

Transplantation 2019 Feb 7. Epub 2019 Feb 7.

Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/TP.0000000000002661DOI Listing
February 2019

Genotypic variants influencing acute allograft rejection; inherited susceptibility also matters.

Transplantation 2019 Feb 7. Epub 2019 Feb 7.

Kidney Transplant Unit, Nephrology department, Bellvitge University Hospital, IDIBELL, Barcelona, Spain.

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http://dx.doi.org/10.1097/TP.0000000000002660DOI Listing
February 2019

Renal Replacement Therapy in the ICU.

Crit Care Med 2019 Feb 13. Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ.

Objectives: The incidence of acute kidney injury in critically ill patients is increasing steeply. Acute kidney injury in this setting is associated with high morbidity and mortality. There is no doubt that renal replacement therapy for the most severe forms of acute kidney injury can be life saving, but there are a number of uncertainties about the optimal application of renal replacement therapy for patients with acute kidney injury. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003701DOI Listing
February 2019
1 Read

Dietary protein intake and kidney function decline after myocardial infarction: the Alpha Omega Cohort.

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Post-myocardial infarction (MI) patients have a doubled rate of kidney function decline compared with the general population. We investigated the extent to which high intake of total, animal and plant protein are risk factors for accelerated kidney function decline in older stable post-MI patients.

Methods: We analysed 2255 post-MI patients (aged 60-80 years, 80% men) of the Alpha Omega Cohort. Read More

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http://dx.doi.org/10.1093/ndt/gfz015DOI Listing
February 2019

Near-drowning: new perspectives for human hypoxic acute kidney injury.

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine D, Rambam Health Care Campus and Ruth & Bruce Rappaport Faculty of Medicine, Technion-IIT, Haifa, Israel.

Concepts regarding hypoxic acute kidney injury (AKI) are derived from widely used warm ischemia-reflow (WIR) models, characterized by extensive proximal tubular injury and associated with profound inflammation. However, there is ample clinical and experimental data indicating that hypoxic AKI may develop without total cessation of renal blood flow, with a different injury pattern that principally affects medullary thick limbs in the outer medulla. This injury pattern likely reflects an imbalance between blood and oxygen supply and oxygen expenditure, principally for tubular transport. Read More

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http://dx.doi.org/10.1093/ndt/gfz016DOI Listing
February 2019
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Association of Nonsteroidal Anti-inflammatory Drug Prescriptions With Kidney Disease Among Active Young and Middle-aged Adults.

JAMA Netw Open 2019 Feb 1;2(2):e187896. Epub 2019 Feb 1.

Division of Primary Care and Population Health, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Importance: Concern about the renal effects of nonsteroidand al anti-inflammatory drugs (NSAIDs) among young, healthy adults has been limited, but more attention may be warranted given the prevalent use of these agents.

Objective: To test for associations between dispensed NSAIDs and incident acute kidney injury and chronic kidney disease while controlling for other risk factors.

Design, Setting, And Participants: This retrospective, longitudinal cohort study used deidentified medical and administrative data on 764 228 active-duty US Army soldiers serving between January 1, 2011, and December 31, 2014. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.7896DOI Listing
February 2019

Con: vascular access surveillance in mature fistulas: is it worthwhile?

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Division of Nephrology, University Health Network-Toronto General Hospital, Toronto, ON, Canada.

The risks and benefits of hemodialysis arteriovenous (AV) access surveillance have been debated since the introduction of AV access surveillance techniques. The debate is fuelled by the lack of robust, high-quality evidence with consistent and comparable patient-important outcomes. Additionally, there is a lack of clarity regarding the diagnostic cut points for AV access stenosis using the various surveillance techniques, questions about the appropriateness of the 'knee-jerk' response to intervention on a stenosis >50% regardless of the presence of clinical indicators and whether the intervention results in desired patient-important outcomes. Read More

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http://dx.doi.org/10.1093/ndt/gfz004DOI Listing
February 2019

Anti-myeloperoxidase antibody positivity in patients without primary systemic vasculitis.

Clin Exp Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

UCL Centre for Nephrology, Royal Free Hospital, London, UK.

Objectives: We aimed to elucidate the frequency and associations of MPO-ANCA positivity in patients without ANCA-associated vasculitis (AAV), in a large urban, multi-ethnic teaching hospital.

Methods: Retrospective review of 200 patients identified as MPO-ANCA positive over a five-year period at Royal Free Hospital, London, UK.

Results: The incidence of anti-MPO positivity in patients without AAV was 39. Read More

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February 2019

Clinical features of thirty-two patients with anti-melanoma differentiation-associated gene 5 antibodies.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology and Immunology of the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objectives: To investigate the clinical characteristics of patients positive for anti-melanoma differentiation-associated gene 5 (MDA5) antibodies, and to analyse the potential pathogenesis of anti-MDA5 antibodies.

Methods: The clinical manifestations, serological tests, imaging features, treatments, and prognoses of 32 anti-MDA5 antibody-positive patients diagnosed in the Rheumatology and Immunology Department of the Second Affiliated Hospital of Chongqing Medical University from September 2015 to August 2018 were analysed.

Results: Of the 32 anti-MDA5 antibody-positive patients, eleven patients were clinically diagnosed with interstitial pneumonia with autoimmune features (IPAF), ten patients were diagnosed with clinically amyopathic dermatomyositis (CADM), six patients were diagnosed with dermatomyositis (DM) and five patients were diagnosed with anti-synthetase syndrome (ASS). Read More

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February 2019

Oseltamivir for prophylaxis of influenza in vaccinated hemodialysis patients.

Infect Control Hosp Epidemiol 2019 Feb 15:1-2. Epub 2019 Feb 15.

Division of Medical Microbiology, Department of Laboratory Medicine,AZ Sint-Jan Brugge-Oostende AV,Brugge,Belgium.

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http://dx.doi.org/10.1017/ice.2019.11DOI Listing
February 2019

The Relationship between Prostate Cancer and Metformin Consumption: A Systematic Review and Meta-Analysis study.

Curr Pharm Des 2019 Feb 15. Epub 2019 Feb 15.

Department of Medical Surgical, Faculty of Nursing and Midwifery, Shahrekord University of Medical Sciences, Shahrekord. Iran.

Introduction: Prostate cancer is the most common malignant cancer in men worldwide and after lung cancer is the second leading cause of cancer deaths in men. The purpose of this study was to investigate the relationship between prostate cancer and metformin consumption in men.

Method: The current study is a systematic and meta-analysis review based on the PRISMA statement. Read More

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http://dx.doi.org/10.2174/1381612825666190215123759DOI Listing
February 2019

The role of sodium glucose cotransporter-2 (SGLT-2) inhibitors in heart failure and chronic kidney disease in type 2 diabetes.

Curr Med Res Opin 2019 Feb 15:1-13. Epub 2019 Feb 15.

e Division of Nephrology , St. Michael's Hospital , Toronto , Ontario , Canada.

Background: Heart failure (HF) and chronic kidney disease (CKD) are responsible for substantial morbidity and mortality in individuals with type 2 diabetes (T2D).

Methods: This review discusses the significance of these comorbidities of T2D and current options for managing them, with a focus on sodium-glucose cotransporter-2 (SGLT-2) inhibitors. Based on a focused literature search of cardiovascular outcomes trials (CVOTs), this review assessed the effects of SGLT-2 inhibitors in individuals with T2D with or without established cardiovascular disease (CVD). Read More

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http://dx.doi.org/10.1080/03007995.2019.1576479DOI Listing
February 2019

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turchia.

Background: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long term results in children with PUV.

Methods: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03272-7DOI Listing
February 2019
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Topical tacrolimus and steroids modulate T cells in acute rejection of hand allotransplantation: Two case reports.

Microsurgery 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Acute rejection is not uncommon after vascularized composite allotransplantation. We reported the effects of adjunctive topical immunosuppressant with topical tacrolimus (Protopic®) and steroid cream (Clobetasol®) in the management of acute rejection in two hand transplantation patients. Case 1 is a 45-year-old male with distal forearm deficit 4 years ago and Case 2 is a 30-year-old male with a proximal forearm deficiency 2 years ago, respectively. Read More

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http://dx.doi.org/10.1002/micr.30439DOI Listing
February 2019

The apical Na -HCO cotransporter Slc4a7 (NBCn1) does not contribute to bicarbonate transport by mouse salivary gland ducts.

J Cell Physiol 2019 Feb 14. Epub 2019 Feb 14.

Secretory Mechanisms and Dysfunctions Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland.

The HCO secretion mechanism in salivary glands is unclear but is thought to rely on the co-ordinated activity of multiple ion transport proteins including members of the Slc4 family of bicarbonate transporters. Slc4a7 was immunolocalized to the apical membrane of mouse submandibular duct cells. In contrast, Slc4a7 was not detected in acinar cells, and correspondingly, Slc4a7 disruption did not affect fluid secretion in response to cholinergic or β-adrenergic stimulation in the submandibular gland (SMG). Read More

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http://dx.doi.org/10.1002/jcp.28306DOI Listing
February 2019

Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy.

Rheumatol Ther 2019 Feb 14. Epub 2019 Feb 14.

Nephrology Division, University Hospital Limerick, Graduate Entry Medical School, Health Research Institute, University of Limerick, Limerick, Ireland.

Introduction: The rate of adverse renal events has been shown to be higher in patients treated with lesinurad plus a xanthine-oxidase inhibitor (XOI) than in patients treated only with a XOI. We reassessed the risks for various adverse renal events from a different perspective and devised a hypothesis to explain the results.

Methods: We used data from phase 3 trials that were publicly available from the full prescribing information document and estimated the relative risk and the number needed to treat for increased serum creatinine (sCri), renal failure, and renal lithiasis. Read More

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http://dx.doi.org/10.1007/s40744-019-0143-9DOI Listing
February 2019

The role of neurotrophins in psychopathology and cardiovascular diseases: psychosomatic connections.

J Neural Transm (Vienna) 2019 Feb 14. Epub 2019 Feb 14.

Department of Family Medicine, Semmelweis University, Budapest, Hungary.

Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. Read More

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http://dx.doi.org/10.1007/s00702-019-01973-6DOI Listing
February 2019

Diagnosing Post-transplant Diabetes - The Need for Capillary Glucose Monitoring.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):852-853

Department of Endocrinology, Narayana Health City, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/ijem.IJEM_584_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330854PMC
February 2019

Flash Glucose Monitoring in Subjects with Diabetes on Hemodialysis: A Pilot Study.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):848-851

Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.

Background: In patients with diabetes related end-stage renal disease (ESRD) on hemodialysis, blood glucose management can be challenging due to the kinetics of glucose and insulin in addition to other factors. The glucose monitoring systems which measure glucose levels continuously may be useful to study the glucose profile of patients with diabetes undergoing hemodialysis. Our study is designed to use ambulatory glucose profile to study the glucose pattern - during, before, and after a session of hemodialysis. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_520_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330844PMC
February 2019