131,736 results match your criteria Nephrology dialysis transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association[Journal]


Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress.

Prostaglandins Other Lipid Mediat 2019 Apr 19. Epub 2019 Apr 19.

Institute for Food Toxicology, University of Veterinary Medicine Hannover, Hannover, Germany; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany. Electronic address:

In mammals, epoxy-polyunsaturated fatty acids (epoxy-PUFA) are enzymatically formed from naturally occurring all-cis PUFA by cytochrome P450 monooxygenases leading to the generation of cis-epoxy-PUFA (mixture of R,S- and S,R-enantiomers). In addition, also non-enzymatic chemical peroxidation gives rise to epoxy-PUFA leading to both, cis- and trans-epoxy-PUFA (mixture of R,R- and S,S-enantiomers). Here, we investigated for the first time trans-epoxy-PUFA and the trans/cis-epoxy-PUFA ratio as potential new biomarker of lipid peroxidation. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2019.04.004DOI Listing

LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum.

Free Radic Biol Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, University of Perugia, 06126, Perugia, Italy.

The role of vitamin E in both enzymatic and free radical-dependent metabolism of polyunsaturated fatty acids (PUFAs) has been well demonstrated. This study proposed a new LC-MS/MS method to quantify the main vitamin E forms, their metabolites and main PUFA species in human blood, since, at present, there are not procedures able to simultaneously determine these two classes of compounds. After the optimization of sample treatment and reverse-phase separation conditions, tandem mass spectrometry detection was evaluated experimenting both positive and negative electrospray ionization modes. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.017DOI Listing

Blood and urine biomarkers in chronic kidney disease: An update.

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Nephrology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Nephrology Department, Serdang Hospital, Selangor, Malaysia.

Introduction: Chronic kidney disease (CKD) is a silent disease. Most CKD patients are unaware of their condition during the early stages of the disease which poses a challenge for healthcare professionals to institute treatment or start prevention. The trouble with the diagnosis of CKD is that in most parts of the world, it is still diagnosed based on measurements of serum creatinine and corresponding calculations of eGFR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193181
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http://dx.doi.org/10.1016/j.cca.2019.04.069DOI Listing
April 2019
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Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function.

PLoS One 2019 22;14(4):e0215617. Epub 2019 Apr 22.

Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: C1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human studies have evaluated circulating levels of this adipokine in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, and coronary artery diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215617PLOS

Enhancing Natural Killer and CD8 T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 T Cells with HLA-E Monospecific Monoclonal Antibodies.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):38-59

4 Department of Pediatrics and Pathology, Children's Hospital, Keck School of Medicine, USC, Los Angeles, California.

Cytotoxic NK/CD8 T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A. The NK/CD8 T cell cytotoxic capability is lost when tumor-associated human leukocyte antigen, HLA-E, binds the CD94/NKG2A receptor, resulting in tumor progression and reduced survival. Read More

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http://dx.doi.org/10.1089/mab.2018.0043DOI Listing

Evidence-Based Reviews: Trends in Nephrology Nursing.

Nephrol Nurs J 2019 Mar-Apr;46(2):249-259

Research Assistant, London Health Sciences Centre, London, Ontario, Canada.

Evidence-based practice (EBP) is one of the essential components of nephrology nursing. Reviews of such evidence are important as a means to synthesize research findings into one meaningful form of data. Publication trends of evidence reviews in nephrology nursing are unknown. Read More

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Standing on the Shoulders of Giants: Innovations in Dialysis.

Nephrol Nurs J 2019 Mar-Apr;46(2):223-233

Renal and Transplant Clinical Nurse Specialist, the University of Washington Medical Center, Seattle, WA.

Prior to the 1960s, chronic hemodialysis was limited by vascular access. Pioneers in dialysis technology created the first artificial kidney, chronic vascular access for hemodialysis, and peritoneal dialysis access. Now it is estimated that 600,000 people in the United States and over 2 million people worldwide receive renal replacement therapy. Read More

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An Interview with Neiltje Gedney - Home Dialyzor and Patient Advocate.

Nephrol Nurs J 2019 Mar-Apr;46(2):173-176

spent seven years as a peritoneal dialysis nurse with DaVita and is currently working with a private practice nephrology physician office.

This article describes one woman's journey to home hemodialysis therapy. Her training and trials in adjusting to the therapy led to a passion for promoting improvements in dialysis for herself and others. Ms. Read More

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Evolution of Nephrology Nursing as Reflected in the Early Nursing Literature.

Authors:
Karen C Robbins

Nephrol Nurs J 2019 Mar-Apr;46(2):145-154

Associate Editor of the Nephrology Nursing Journal.

This article provides a historical overview of some of the early nursing literature. These articles reveal early perceptions and writings about renal anatomy and physiology, and nursing implications for care, including acute and chronic kidney disease, peritoneal and hemodialysis, and kidney transplantation. Read More

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Every Nurse Is a Leader: Building on 50 Years of Nephrology Nursing Leadership.

Authors:
Tamara M Kear

Nephrol Nurs J 2019 Mar-Apr;46(2):101-154

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American Nephrology Nurses Association - Celebrating 50 Years!

Authors:
Beth Ulrich

Nephrol Nurs J 2019 Mar-Apr;46(2):93

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Efficacy of furosemide for treatment of liver cirrhosis: A systematic review protocol of randomized controlled trial.

Medicine (Baltimore) 2019 Apr;98(16):e15300

Department of Nephrology, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China.

Background: Previous clinical studies have reported that furosemide can be used to treat liver cirrhosis (LC) effectively. However, no study systematically explored this issue. This systematic review aims to investigate the efficacy and safety of furosemide for treatment of LC. Read More

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http://dx.doi.org/10.1097/MD.0000000000015300DOI Listing

Long-segment central venous occlusion in a hemodialysis patient treated by segmented sharp recanalization strategy: A case report.

Medicine (Baltimore) 2019 Apr;98(16):e15208

Division of Nephrology, Department of Internal Medicine.

Introduction: Among hemodialysis population, central vein occlusion (CVO) is a common complication. Percutaneous transluminal angioplasty has become the mainstay treatment these days. But the treatment of long-segment central venous occlusion remains difficult. Read More

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http://dx.doi.org/10.1097/MD.0000000000015208DOI Listing

A case report of cyclosporine-induced myopathy with subacute muscular atrophy as initial presentation.

Medicine (Baltimore) 2019 Apr;98(16):e15206

Department of Nephrology.

Rationale: Cyclosporine A (CsA) is a potent immunosuppressive agent originally used to prevent rejection after organ transplantation but now more frequently used for treatment of refractory autoimmune diseases. It can induce adverse effects, such as nephrotoxicity, gastrointestinal reactions, and gingival hyperplasia whist myopathy with subacute muscular atrophy are rare.

Patient Concerns: A 55-year-old male patient with idiopathic membranous nephropathy treated with cyclosporine A at 3 mg/kg/d and prednisone at 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000015206DOI Listing

Immune Checkpoint Inhibitors-Related Cardiotoxicity.

Am J Ther 2019 Apr 16. Epub 2019 Apr 16.

Division of Cardiology, Westchester Medical Center, New York Medical College, Valhalla, NY.

Background: Immunotherapy is a significant breakthrough in cancer therapy in the last decade. Immunotherapy is better tolerated compared with chemotherapy. However, it does have side effects, and one of the rare and serious side effects of immunotherapy is cardiotoxicity. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000988DOI Listing

Balancing the risk and rewards of utilizing organs from hepatitis C viremic donors.

Curr Opin Organ Transplant 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Liver Center, Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts, USA.

Purpose Of Review: Owing to long waitlist times and high waitlist morbidity and mortality, strategies to increase utilization of hepatitis C viremic-deceased donor organs are under investigation in kidney, liver, heart, and lung transplantation.

Recent Findings: Direct-acting antiviral medications for hepatitis C virus infection have high cure rates and are well tolerated. Small, single-center trials in kidney and heart transplant recipients have demonstrated that with early posttransplant direct-acting antiviral therapy, 100% of uninfected recipients of hepatitis C viremic organs have been cured of infection after transplantation. Read More

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http://dx.doi.org/10.1097/MOT.0000000000000651DOI Listing

Teaching modes and social-epistemological dimensions in medical Massive Open Online Courses: Lessons for integration in campus education.

Med Teach 2019 Apr 22:1-10. Epub 2019 Apr 22.

a Center for Innovation in Medical Education, Leiden University Medical Center , Leiden University , Leiden , The Netherlands.

Purpose: Medical Massive Open Online Courses (MOOCs) have been integrated into formal campus teaching by several universities. However, teaching attributes of medical MOOCs have not been systematically investigated. Additionally, guidelines are needed to inform integration practices. Read More

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http://dx.doi.org/10.1080/0142159X.2019.1592140DOI Listing

[Facilitative glucose transporters: expression, distribution and the relationship to diseases].

Sheng Li Xue Bao 2019 Apr;71(2):350-360

Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an 710021, China.

Facilitative glucose transporters (GLUT) are proteins that mediate glucose transmembrane transport in the form of facilitated diffusion, which play an important role in regulating cell energy metabolism. There are many breakthroughs in researches of facilitative GLUT in recent years. It has been known that there are 14 subtypes of facilitative GLUT with obvious tissue specificity in distribution and physiological function. Read More

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April 2019
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The effects of cool dialysate on quality of sleep among patients undergoing hemodialysis: A randomized clinical trial.

J Educ Health Promot 2019 14;8:56. Epub 2019 Mar 14.

Department of Nursing, School of Nursing and Midwifery, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Introduction: Low quality of sleep is a common problem among hemodialysis patients. This study was conducted to evaluate the effect of a cold dialysis solution on the quality of sleep in patients undergoing hemodialysis.

Methodology: This double-blind clinical trial was performed on 26 hemodialysis patients with chronic renal failure and sleep disorders in the dialysis center of Sabzevar, Iran, in 2016-2017. Read More

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http://dx.doi.org/10.4103/jehp.jehp_205_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442248PMC

Systemic p-ANCA vasculitis with fatal outcome, arising in the setting of methimazole use.

Clin Nephrol Case Stud 2019 16;7:23-26. Epub 2019 Apr 16.

Department of Pathology and Laboratory Medicine and.

Here we report a fatal case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) due to methimazole use in a 64-year-old woman. She was initially hospitalized for abdominal pain and possible colitis, and subsequently developed hematuria, renal failure, and hemoptysis. The serologic work-up revealed positive antinuclear antibody (ANA) and perinuclear-antineutrophilic cytoplasm antibodies (p-ANCA), with positive antimyeloperoxidase. Read More

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http://dx.doi.org/10.5414/CNCS109759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470634PMC

Successful Tenckhoff catheter salvage in a patient with peritoneovesical fistula: A case report.

Clin Nephrol Case Stud 2019 16;7:17-22. Epub 2019 Apr 16.

Department of Nephrology, Sri Ramachandra Medical College, Chennai.

Introduction: Many techniques are available for inserting peritoneal dialysis (PD) or continuous ambulatory peritoneal dialysis (CAPD) catheters, with varying possible complications. We report a case of bladder perforation that was managed with catheter salvage.

Case Report: A 48-year-old man with end-stage renal disease (ESRD) underwent CAPD catheter placement percutaneously, with tip in the pelvis. Read More

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http://dx.doi.org/10.5414/CNCS109656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472324PMC

Influence of hemodialysis on pramipexole pharmacokinetics: Lessons from two cases and literature review.

Clin Nephrol Case Stud 2019 22;7:11-16. Epub 2019 Mar 22.

Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain Brussels.

Background: Restless legs syndrome (RLS) is not a rare condition in patients on long-term dialysis. Pramipexole is a small molecule used in the treatment of idiopathic and uremic RLS. Although some information concerning the efficacy and safety of pramipexole in uremic patients is available, data concerning the pharmacokinetics of pramipexole in hemodialysis (HD) are lacking. Read More

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http://dx.doi.org/10.5414/CNCS109641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448051PMC

Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy.

Case Rep Transplant 2019 17;2019:9839780. Epub 2019 Mar 17.

Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.

Gastrointestinal mucormycosis is a rare infection in solid organ transplant recipients. Our patient, a 79-year-old male, presented with severe dysphagia and odynophagia about 2 weeks after receiving a renal transplant. An upper gastrointestinal (UGI) endoscopy revealed esophagitis and gastric ulceration, the cultures from which grew Rhizopus species. Read More

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http://dx.doi.org/10.1155/2019/9839780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441519PMC

Suppression of Gut Bacterial Translocation Ameliorates Vascular Calcification through Inhibiting Toll-Like Receptor 9-Mediated BMP-2 Expression.

Oxid Med Cell Longev 2019 17;2019:3415682. Epub 2019 Mar 17.

Department of Physiology and Pathophysiology, School of Basic Medical Science, Peking University Health Science Center, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing 100191, China.

Aims: Vascular calcification (VC) is a primary risk factor for cardiovascular mortality in chronic renal failure (CRF) patients; thus, effective therapeutic targets are urgently needed to be explored. Here, we identified the role of intestinal bacterial translocation in CRF-related VC.

Methods And Results: Antibiotic supplementation by oral gavage significantly suppressed intestinal bacterial translocation, CRF-related VC, and aortic osteogenic gene and Toll-like receptor (TLR) gene expression in CRF rats. Read More

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http://dx.doi.org/10.1155/2019/3415682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441534PMC

Meta-analysis comparing the effects of statins on the risk of diarrhea.

Proc (Bayl Univ Med Cent) 2018 Oct 19;31(4):447-452. Epub 2018 Sep 19.

Division of Nephrology and Hypertension, Department of Medicine, Mayo ClinicRochesterMinnesota.

A literature search was performed through May 2017. Studies that compared the risk of developing infection (CDI) and/or the clinical outcomes of CDI in patients who received statin treatment versus those who did not receive statins were included. Ten observational studies with 37,109 patients were included. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
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http://dx.doi.org/10.1080/08998280.2018.1472994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459672PMC
October 2018
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The serum sclerostin level is positively associated with the aortic augmentation index in patients on peritoneal dialysis.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;31(2):102-106

Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Objective: Sclerostin is a canonical Wingless (Wnt)/β-catenin signaling pathway inhibitor and had been associated with high arterial stiffness in patients with chronic kidney disease. The aortic augmentation index (AIx), a noninvasive method of assessing central hemodynamics/wave reflections, has been widely used as a clinical index of arterial stiffness. The aim of this study was to evaluate the relationship between fasting serum sclerostin levels and AIx values in peritoneal dialysis (PD) patients. Read More

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http://www.tcmjmed.com/text.asp?2019/31/2/102/235334
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http://dx.doi.org/10.4103/tcmj.tcmj_90_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450146PMC
April 2019
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Experience with telepathology in combination with diagnostic assistance systems in countries with restricted resources.

J Telemed Telecare 2019 Apr 21:1357633X19840475. Epub 2019 Apr 21.

3 IPath Telemedicine Network gemeinnützige GmbH, Aurich, Germany.

Introduction: We describe the use of telepathology in countries with restricted resources using two diagnosis assistance systems (Isabel and Memem7) in addition to the diagnoses made by experts in pathology via the iPath-Network.

Methods: A total of 156 cases, largely from Afghanistan, were analysed; 18 cases had to be excluded because of poor image quality.

Results: Of the remaining 138 cases (100%), a responsible physician provided a tentative diagnosis for 61. Read More

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http://journals.sagepub.com/doi/10.1177/1357633X19840475
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http://dx.doi.org/10.1177/1357633X19840475DOI Listing
April 2019
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Lidocaine-Propitocain Cream, a Eutectic Mixture of Local Anesthetics, Effectively Relieves Pain Associated with Vascular Access Intervention Therapy in Patients Undergoing Hemodialysis: A Placebo-Controlled, Double-Blind, Crossover Study.

Ther Apher Dial 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Vascular access intervention therapy (VAIVT) is necessary to maintain vascular access in patients undergoing hemodialysis. VAIVT-associated vasodilatation is painful. However, few reports have focused on effective pain relief at the time of VAIVT. Read More

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http://dx.doi.org/10.1111/1744-9987.12813DOI Listing

Hyponatremia may be an under-recognized complication after desmopressin to reduce uremic bleeding in kidney biopsy.

Nephrology (Carlton) 2019 Apr 21. Epub 2019 Apr 21.

Department of Renal Medicine, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1111/nep.13398DOI Listing

Evidence-Based Strategies and Recommendations for Preservation of Central Venous Access in Children.

JPEN J Parenter Enteral Nutr 2019 Apr 21. Epub 2019 Apr 21.

VANGUARD, Venous Access (VANGUARD) Task Force, Society of Interventional Radiology (SIR), Pittsburgh, Pennsylvania, USA.

Children with chronic illness often require prolonged or repeated venous access. They remain at high risk for venous catheter-related complications (high-risk patients), which largely derive from elective decisions during catheter insertion and continuing care. These complications result in progressive loss of the venous capital (patent and compliant venous pathways) necessary for delivery of life-preserving therapies. Read More

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http://dx.doi.org/10.1002/jpen.1591DOI Listing

Clinical outcomes after ABO-incompatible renal transplantation: a systematic review and meta-analysis.

Lancet 2019 Apr 18. Epub 2019 Apr 18.

Clinic of Nephrology and Hypertension, Diabetology and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. Electronic address:

Background: ABO-incompatible renal transplantation (ABOi-rTx) is increasingly used to overcome organ shortage. Evidence about its non-inferiority in comparison with ABO-compatible renal transplantation (ABOc-rTx) needs to be analysed at early and late timepoints. We aimed to investigate differences in outcome after ABOi-rTX and ABOc-rTX. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32091-9DOI Listing

Severe quetiapine voluntary overdose successfully treated with a new hemoperfusion sorbent.

Int J Artif Organs 2019 Apr 22:391398819837686. Epub 2019 Apr 22.

2 Nephrology, Dialysis and Transplantation Unit, Azienda Ospedaliera-Universitaria di Bologna, Bologna, Italy.

Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. Read More

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http://dx.doi.org/10.1177/0391398819837686DOI Listing

18-Oxocortisol Synthesis in Aldosterone-Producing Adrenocortical Adenoma and Significance of KCNJ5 Mutation Status.

Hypertension 2019 Apr 22:HYPERTENSIONAHA11812064. Epub 2019 Apr 22.

From the Division of Nephrology, Endocrinology and Vascular Medicine, Department of Medicine (Y.T., R.M., M.K., S.I., F.S.), Tohoku University Hospital, Sendai, Miyagi, Japan.

Peripheral 18-oxocortisol (18oxoF) level could contribute to the detection of aldosterone-producing adenoma (APA) in patients with primary aldosteronism. However, peripheral 18oxoF varies among such patients, which is a big drawback concerning its clinical application. We studied 48 cases of APA, 35 harboring KCNJ5 mutation, to clarify the significance of clinical and pathological parameters about peripheral 18oxoF. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12064DOI Listing

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

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http://dx.doi.org/10.1111/apha.13286DOI Listing
April 2019
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MiR-204-5p: a novel candidate urinary biomarker of Xp11.2 translocation renal cell carcinoma.

Cancer Sci 2019 Apr 21. Epub 2019 Apr 21.

Department of Molecular Genetics.

Xp11.2 translocation renal cell carcinoma (Xp11 tRCC) is a rare sporadic pediatric kidney cancer caused by constitutively active TFE3 fusion proteins. Tumors in patients with Xp11 tRCC tend to recur and undergo frequent metastasis, in part due to lack of methods available to detect early stage disease. Read More

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http://dx.doi.org/10.1111/cas.14026DOI Listing
April 2019
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Factors Predicting Kidney Delayed Graft Function Among Recipients of Simultaneous Liver-Kidney Transplantation: Single Center Experience.

Clin Transplant 2019 Apr 21:e13569. Epub 2019 Apr 21.

Division of Transplantation and Hepatobiliary Surgery, University of Florida, FL, USA.

Background: Kidney delayed graft function (kDGF) remains a challenging problem following simultaneous liver and kidney transplantation (SLKT) with a reported incidence up to 40%. Given the scarcity of renal allografts, it is crucial to minimize the development of kDGF among SLKT recipients to improve patient and graft outcomes. We sought to assess the role of preoperative recipient and donor/graft factors on developing kDGF among recipients of SLKT. Read More

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http://dx.doi.org/10.1111/ctr.13569DOI Listing

Lipopolysaccharide in systemic circulation induces activation of inflammatory response and oxidative stress in cardiorenal syndrome type 1.

J Nephrol 2019 Apr 20. Epub 2019 Apr 20.

Department of Nephrology, Dialysis and Transplantation, St Bortolo Hospital, International Renal Research Institute Vicenza, Via Rodolfi, 37, 36100, Vicenza, Italy.

Background: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury. In this study, we evaluate the role of lipopolysaccharide (LPS) and various inflammatory markers in the developing acute kidney injury (AKI) in acute heart failure (AHF) patients.

Methods: We enrolled 31 AHF patients and 20 CRS type 1 (the cause of AKI was presumed to be related to cardiac dysfunction) and 17 healthy volunteers without AHF, AKI or CKD, as control group (CTR). Read More

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http://dx.doi.org/10.1007/s40620-019-00613-2DOI Listing

Renal handling of zinc in chronic kidney disease patients and the role of circulating zinc levels in renal function decline.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine, Service of Nephrology and Hypertension, Lausanne University Hospital (CHUV) and University of Lausanne Lausanne, Switzerland.

Background: Zinc deficiency is commonly encountered in chronic kidney disease (CKD). The aims of this study were to assess whether zinc deficiency was related to increased renal excretion of zinc and to the progression of CKD.

Methods: Plasma and 24-h urinary zinc levels, urinary electrolytes and uromodulin were measured in 108 CKD patients and 81 individuals without CKD. Read More

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http://dx.doi.org/10.1093/ndt/gfz065DOI Listing

Association of changes in bone mineral parameters with mortality in haemodialysis patients: insights from the ARO cohort.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department of Nephrology, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany.

Background: There is little information in haemodialysis (HD) patients on whether temporal changes in serum calcium, phosphate or intact parathyroid hormone (iPTH) are associated with mortality.

Methods: We analysed associations of phosphate, total calcium and iPTH with all-cause and cardiovascular mortality in 8817 incident HD patients from the European second Analyzing Data, Recognizing Excellence and Optimizing Outcomes (AROii) cohort enrolled in 2007-09, which were prospectively followed for a median of 3 years, using time-dependent Cox proportional hazards models. We evaluated changes in risk over time depending on changes in phosphate, calcium or iPTH. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz060DOI Listing
April 2019
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A newly established clinical registry of minimal change disease and focal and segmental glomerulosclerosis in Germany.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1093/ndt/gfz046DOI Listing

Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.

BMJ Open 2019 Apr 20;9(4):e024210. Epub 2019 Apr 20.

Division of Population Medicine, School of Medicine, Wales Centre for Primary and Emergency Care Research (PRIME Centre Wales), Cardiff University, Cardiff, UK.

Introduction: Current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear.UTI is relatively common but difficult to diagnose in children as symptoms are non-specific. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02421
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-024210DOI Listing
April 2019
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Splenic artery aneurysm in a patient of autosomal dominant polycystic kidney disease: beyond tenuous concomitance!

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

Splenic artery aneurysm (SAA) is rare, with risk of rupture especially if diameter is >2 cm. It is usually asymptomatic and detected incidentally on imaging either in young pregnant women or elderly cirrhotic patients. Extracranial vascular abnormalities known to be associated with autosomal dominant polycystic kidney disease (ADPKD) include ascending aortic aneurysms, dissections of coronary and vertebral arteries and rarely SAA. Read More

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http://dx.doi.org/10.1136/bcr-2018-228552DOI Listing

Deceptively asymptomatic cryptococcaemia in a renal transplant recipient: the lull before a storm.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Cryptococcal infection constitutes around 3% of opportunistic infections in solid organ transplant recipients. Most common organ affected in renal transplant recipients (RTRs) is central nervous system and usually presents with chronic meningoencephalitis (CME). Ischaemic stroke as a consequence of cryptococcal meningoencephalitisis rare and possibly due to the involvement of intracranial vessel by exudates causing vasculitis-related thrombosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-228115DOI Listing

Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

J Pediatr Urol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Nephrology, University Hospital Vall d'Hebron, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain; School of Medicine, Universitat Autonoma de Barcelona, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain.

Introduction: Pediatric donation is underutilized because of presumed increased risk of vascular thrombosis (VT) and graft loss. Using young pediatric donors (YPDs) for young pediatric recipients (YPRs) is suggested to be even at greater risk and therefore precluded in many centers. The aim of this study was to analyze the outcome of kidney transplantation (KT) from YPD to age-matched YPR. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.015DOI Listing

Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.

Toxicology 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmacy, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Myocarditis is a serious hazard to human life and is difficult to treat due to the proliferation of inflammatory lesions in the myocardium. Leonurine (LE) is a plant phenolic alkaloid extracted from Herba leonuri that has demonstrated cardioprotective effects in many preclinical experiments. However, whether LE can be used for myocarditis therapy has not been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183070
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http://dx.doi.org/10.1016/j.tox.2019.04.011DOI Listing
April 2019
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Antimalarials in IgA Nephropathy: Did Our Supportive Therapy Armamentarium Just Increase?

Authors:
Jürgen Floege

Am J Kidney Dis 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology, Medizinische Klinik II, RWTH University Hospital Aachen, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2019.02.022DOI Listing

Effects of Water Loading on Observed and Predicted Plasma Sodium, and Fluid and Urine Cation Excretion in Healthy Individuals.

Am J Kidney Dis 2019 Apr 17. Epub 2019 Apr 17.

Section of Nephrology, Department of Internal Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

Rationale & Objective: The discovery of sodium storage without concurrent water retention suggests the presence of an additional compartment for sodium distribution in the body. The osmoregulatory role of this compartment under hypotonic conditions is not known.

Study Design: Experimental interventional study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.021DOI Listing
April 2019
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Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Clinic for Nephrology and Critical Care Medicine, Campus Virchow-Klinikum, Charité Universitätsmedizin Berlin, Germany; Center for Cardiovascular Research, Medical Faculty of the Charité Berlin, Berlin, Germany.

Anti-angiotensin II type 1 receptor (AT1R) antibodies have been associated with allograft rejection. We hypothesized that circulating AT1R antibodies might identify kidney transplant recipients at increased risk of allograft rejection and loss who are not identified by the HLA system. We prospectively enrolled 1845 kidney transplant recipients from two centers. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.030DOI Listing

SON haploinsufficiency causes impaired pre-mRNA splicing of CAKUT genes and heterogeneous renal phenotypes.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama, USA. Electronic address:

Although genetic testing is increasingly used in clinical nephrology, a large number of patients with congenital abnormalities of the kidney and urinary tract (CAKUT) remain undiagnosed with current gene panels. Therefore, careful curation of novel genetic findings is key to improving diagnostic yields. We recently described a novel intellectual disability syndrome caused by de novo heterozygous loss-of-function mutations in the gene encoding the splicing factor SON. Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.025DOI Listing