126,640 results match your criteria Nephrology dialysis transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association[Journal]


Effect of Sodium Glucose Co-Transporter-2 Inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus.

Horm Metab Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Biochemistry, Saolta University Health Care Group (SUHCG), Galway University Hospitals, Galway, Ireland.

The aldosterone to renin ratio (ARR) is recommended for case detection of primary aldosteronism (PA). Several factors including medications can undermine its diagnostic accuracy. The objective was to explore the effect of Sodium Glucose Co-Transporter-2 Inhibition on the ARR in patients with type 2 diabetes mellitus (T2DM) who were prescribed a Sodium Glucose Co-Transporter-2 Inhibitor (SGLT-2i) as part of routine clinical care. Read More

View Article
December 2018
1 Read

Virtual Reality Simulation in Peritoneal Dialysis Training: The Beginning of a New Era.

Blood Purif 2018 Dec 6:1-5. Epub 2018 Dec 6.

Weltenmacher GmbH, VR Training-Application, Düsseldorf, Germany.

Background/aim: Peritonitis rates in peritoneal dialysis (PD) vary considerably not only across countries but also between centers in the same country. Patient education has been shown to significantly reduce infection rates but up till now training lacks standardization with patients being trained using different methods and media (e.g. Read More

View Article
December 2018
3 Reads

Direct Effect of Septic Plasma in Human Cell Lines Viability.

Blood Purif 2018 Dec 6:1-7. Epub 2018 Dec 6.

Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, Italy.

Background: Sepsis is a life-threatening condition often associated with a high incidence of multiple organs injury. Several papers suggested the immune response by itself, with the production of humoral inflammatory mediators, is crucial in determining organ injury. However, little is known of how sepsis directly induces organ injury at the cellular levels. Read More

View Article
December 2018
1 Read

Proteomic analysis of olfactory bulb suggests CACNA1E as a promoter of CREB signaling in microbiota-induced depression.

J Proteomics 2018 Dec 3. Epub 2018 Dec 3.

Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing Medical University, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China. Electronic address:

Major depressive disorders impact approximately 17% of the population worldwide, whose high morbidity and considerable adversity have resulted in enormous social and economic burden. In addition, clinically depressed patients often show reduced volume of olfactory bulb (OB) and decreased olfactory sensitivity. Although mounting evidence conveyed that the gut microbiota may implicate the pathophysiology of major depressive disorder (MDD) via the microbe-gut-brain axis, knowledge about its distinctive molecular mechanism is rudimentary. Read More

View Article
December 2018
2 Reads

Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;; Department of Veterans Affairs, Nashville, TN, USA. Electronic address:

Cytochrome CYP450 epoxygenases catalyze the epoxidation of polyunsaturated fatty acids including arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. The arachidonic acid-derived products are potent pro-angiogenic lipids and promote tumor development and growth. On the other hand, eicosapentaenoic acid- and docosahexaenoic acid-derived products inhibit angiogenesis and play a protective role in certain pathological conditions including cancer. Read More

View Article
December 2018
2 Reads

Plasma donor-derived cell-free DNA kinetics after kidney transplantation using a single tube multiplex PCR assay.

PLoS One 2018 6;13(12):e0208207. Epub 2018 Dec 6.

Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.

Background: After transplantation, cell-free DNA derived from the donor organ (ddcfDNA) can be detected in the recipient's circulation. We aimed to quantify ddcfDNA levels in plasma of kidney transplant recipients thereby investigating the kinetics of this biomarker after transplantation and determining biological variables that influence ddcfDNA kinetics in stable and non-stable patients.

Materials And Methods: From 107 kidney transplant recipients, plasma samples were collected longitudinally after transplantation (day 1-3 months) within a multicenter set-up. Read More

View Article
December 2018

Short communication: Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Departments of Internal Medicine, Division of Nephrology and Transplantation and.

Background: There is an unmet need for reliable minimally invasive diagnostic biomarkers for immunological allograft monitoring and for the detection of acute kidney transplant rejection. Here, targeted proteomic analysis was applied to compare 92 proteins in sera of belatacept-treated patients who had biopsy-proven, acute T cell-mediated rejection (aTCMR) with patients without aTCMR.

Methods: Proximity extension immunoassay (PEA) was used to measure 92 inflammation-related protein concentrations in the pre-rejection and rejection sera of 11 patients with aTCMR and 9 patients without aTCMR. Read More

View Article
December 2018

Blocking Tyr265 nitration of protein phosphatase 2A attenuates nitrosative stress-induced endothelial dysfunction in renal microvessels.

FASEB J 2018 Dec 6:fj201800885RR. Epub 2018 Dec 6.

Division of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Protein tyrosine (Tyr) nitration, the covalent addition of a nitro group (NO) to Tyr residues, is emerging as a candidate mechanism of endothelial dysfunction. Previous studies have shown that Tyr nitration is primarily induced by nitrosative stress, a process characterized by the production of reactive nitrogen species, especially peroxynitrite anion (ONOO), which is considered a secondary product of NO in the presence of superoxide radicals (O). However, the impact of nitrosative stress-induced Tyr nitration on endothelial dysfunction has not been thoroughly elucidated to date. Read More

View Article
December 2018

Separate and interacting effects of the endogenous circadian system and behaviors on plasma aldosterone in humans.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 6. Epub 2018 Dec 6.

Oregon Institute of Occupational Health Sciences, Oregon Health & Science University.

Introduction: Measurements of aldosterone for diagnosis of primary aldosteronism are usually made from blood sampled in the morning when aldosterone typically peaks. We tested the relative contributions and interacting influences of the circadian system, ongoing behaviors and prior sleep to this morning peak in aldosterone.

Methods: To determine circadian rhythmicity and separate effect of behaviors on aldosterone, 16 healthy participants completed a 5-day protocol in dim-light while all behaviors ranging from sleep to exercise were standardized and scheduled evenly across the 24-h circadian period. Read More

View Article
December 2018

The iranian model as a potential solution for the current kidney shortage crisis.

Authors:
Bahar Bastani

Int Braz J Urol 2018 Aug 6;44. Epub 2018 Aug 6.

Division of Nephrology, Saint Louis University Health Science Center, Saint Louis, MO, USA.

View Article

Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Patras University Hospital, Patras, Greece.

There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. Read More

View Article
December 2018

Antiphospholipid score is a novel risk factor for idiopathic osteonecrosis of the femoral head in patients with systemic lupus erythematosus.

Rheumatology (Oxford) 2018 Dec 6. Epub 2018 Dec 6.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objectives: Idiopathic osteonecrosis of the femoral head (ION) is a common complication of SLE associated with CS therapy. Although the pathogenesis of ION involves local bone ischaemia favoured by thrombophilia, the involvement of aPL in lupus ION remains to be elucidated. We have previously reported the aPL score (aPL-S) as a quantitative marker of aPL and the development of thrombotic events in autoimmune diseases. Read More

View Article
December 2018

Glomerular filtration rate: when to measure and in which patients?

Nephrol Dial Transplant 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Dialysis, Transplantation, University of Liège (CHU ULg), Liège, Belgium.

Of the glomerular, tubular and endocrine functions of the kidney, nephrologists have mostly focused their attention on the glomerular functions-albuminuria and glomerular filtration rate (GFR)-to grade the severity of chronic kidney disease (CKD). Although both albuminuria and GFR are associated with renal and cardiovascular morbidity and mortality, the utility of measured GFR (mGFR) has been questioned. GFR when measured adequately is the most precise measure of glomerular function and can be useful to individualize therapy among patients with CKD. Read More

View Article
December 2018
2 Reads

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

View Article
December 2018
2 Reads

Structure and function insights garnered from in silico modeling of the thrombospondin type-1 domain-containing 7A antigen.

Proteins 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Nephrology Section, Boston University Medical Center, Boston, MA.

The thrombospondin type-1 domain containing 7A (THSD7A) protein is known to be one of the antigens responsible for the autoimmune disorder idiopathic membranous nephropathy. The structure of this antigen is currently unsolved experimentally. Here we present a homology model of the extracellular portion of the THSD7A antigen. Read More

View Article
December 2018
6 Reads

The impact of functioning hemodialysis arteriovenous accesses on renal graft perfusion: Results of a pilot study.

J Vasc Access 2018 Dec 6:1129729818817248. Epub 2018 Dec 6.

1 Kidney Transplant Unit, Nephrology Department, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

Introduction:: After a kidney transplant, it is unknown whether the maintenance of a functioning hemodialysis arteriovenous access could have deleterious effects on renal grafts. We hypothesize that maintaining an arteriovenous access can deviate a significant proportion of the cardiac output from the renal graft. The aim of this study was to investigate whether a temporary closure of the arteriovenous access could lead to an increase in graft perfusion. Read More

View Article
December 2018

Validation of a New North American Islet Donor Score for Donor Pancreas Selection and Successful Islet Isolation in a Medium-Volume Islet Transplant Center.

Cell Transplant 2018 Dec 6:963689718816989. Epub 2018 Dec 6.

1 Department of Surgery, University of Chicago, Chicago, IL, USA.

The selection of optimal pancreas donors is one of the key factors in determining the ultimate outcome of clinical islet isolation. North American Islet Donor Score (NAIDS) allows for estimating the chance of the success of islet isolation. It was developed based on the data from over 1000 donors from 11 islet isolation centers and validated in the University of Alberta, Edmonton, on the cohort from the most active islet transplant center. Read More

View Article
December 2018

High renal DC-SIGN cell density is associated with severe renal lesions and poor prognosis in patients with Immunoglobulin A Nephropathy.

Histopathology 2018 Dec 5. Epub 2018 Dec 5.

Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, Hubei, China.

Background And Objectives: In this observational cohort study, we assessed the prognostic value of DC-SIGN cells in pathogenesis and progression of IgA nephropathy (IgAN).

Design, Setting, Participants, & Measurements: A total of 139 adult IgAN patients were enrolled in this study from June 2009 to June 2010. We characterized DC-SIGN cells by immunohistochemistry or immunofluorescence in renal biopsy tissue. Read More

View Article
December 2018

Hepatic Autophagy Deficiency Compromises FXR Functionality and Causes Cholestatic Injury.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Autophagy is important for hepatic homeostasis, nutrient regeneration and organelle quality control. We investigated the mechanisms by which liver injury occurred in the absence of autophagy function. We found that mice deficient in autophagy due to the lack of Atg7 or Atg5, key autophagy-related genes, manifested intracellular cholestasis with increased levels of serum bile acids, a higher ratio of TMCA/TCA in the bile, increased hepatic bile acid load, abnormal bile canaliculi and altered expression of hepatic transporters. Read More

View Article
December 2018
1 Read

Urine proteomic profiling in patients with nephrolithiasis and cystinuria.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Nephrology Division, New York University Langone Medical Center, New York, NY, USA.

Purpose: The purpose of the study was to assess the differences in the concentration and function of urinary proteins between patients with cystine stones (CYS) and healthy controls (HC). We postulated that CYS and HC groups would demonstrate different proteomic profiles.

Methods: A pilot study was performed comparing urinary proteomes of 10 patients with CYS and 10 age- and gender-matched HC, using liquid chromatography-mass spectrometry. Read More

View Article
December 2018
1 Read

The effect of chronic kidney disease on lipid metabolism.

Int Urol Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Division of Nephrology, Department of Medicine, Koc University School of Medicine, 34010, Istanbul, Turkey.

The major cause of death among chronic kidney disease patients is cardiovascular diseases. Cardiovascular and kidney disease are interrelated and increase the severity of each other. Dyslipidemia is one the major causes of cardiovascular disease among chronic kidney disease patients along with diabetes and hypertension. Read More

View Article
December 2018

Growth of children with biliary atresia living with native livers: impact of corticoid therapy after portoenterostomy.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Pediatric Liver and Gut Research Group, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.

We addressed growth of biliary atresia (BA) patients living with native livers between ages 0-6 and effects of post-surgical corticosteroid treatment on growth. Growth charts of 28 BA patients born in Finland between 1987 and 2017 were retrospectively evaluated. Dosage and length of corticosteroid treatment and hydrocortisone substitution were reviewed. Read More

View Article
December 2018

Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway.

Inflammation 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Affiliated Hospital of Southwest Medical University, No. 25, Tai Ping Street, Jiangyang District, 646000, Luzhou, China.

Schisandrin B (SchB) is an active compound extracted from the Chinese herb Schisandra chinensis and shows excellent anti-inflammatory activity. This study was performed to examine the effects of SchB in a rat model of IgA nephropathy (IgAN). IgAN was established in Sprague-Dawley rats by immunization with lipopolysaccharide (LPS), bovine serum albumin, and carbon tetrachloride. Read More

View Article
December 2018

A Report of Chronic Intestinal Pseudo-obstruction Related to Systemic Lupus Erythematosus.

Open Med (Wars) 2018 25;13:562-564. Epub 2018 Nov 25.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Read More

View Article
November 2018
1 Read

Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway.

J Cancer 2018 18;9(22):4150-4155. Epub 2018 Oct 18.

Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.

: Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor worldwide, with a high mortality rate at advanced stages. In this study, we investigated the effect of niclosamide on cell growth and drug sensitivity in human HCC and elucidated the underlying mechanism. Three human HCC cell lines (HepG2, QGY-7703 and SMMC-7721) were used to evaluate the effect of niclosamide. Read More

View Article
October 2018

Zishenwan Decreases Kidney Damage in Recurrent Urinary Tract Infection through the Inhibition of Toll-Like Receptor 4 Signal.

Evid Based Complement Alternat Med 2018 5;2018:5968657. Epub 2018 Nov 5.

Suzhou Academy of Wumen Chinese Medicine, Suzhou 215000, China.

Objectives: To investigate the mechanism of the protective effect of Zishenwan on pyelonephritis rats.

Methods: In the rat model of pyelonephritis, protective effects of Zishenwan, the content of secretory immunoglobulin A (SIg A), and interleukins were detected by ELISA. The expressions of TLR4-NFB pathway were detected by Western blot in renal and urinary tract mucosa. Read More

View Article
November 2018
1 Read

Thrombotic Microangiopathy with Severe Proteinuria Induced by Lenvatinib for Radioactive Iodine-Refractory Papillary Thyroid Carcinoma.

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More

View Article
November 2018

Bartter syndrome: causes, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 9;11:291-301. Epub 2018 Nov 9.

Nephrology Division, Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, Brazil,

Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Mutations of several genes encoding the transporters and channels involved in salt reabsorption in the thick ascending limb cause different types of Bartter syndrome. A poor phenotype-genotype relationship due to the interaction with other cotransporters and different degrees of compensation through alternative pathways is currently reported. Read More

View Article
November 2018
1 Read

Estimated GFR: time for a critical appraisal.

Nat Rev Nephrol 2018 Dec 5. Epub 2018 Dec 5.

Nephrology and Dialysis Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Since 1957, over 70 equations based on creatinine and/or cystatin C levels have been developed to estimate glomerular filtration rate (GFR). However, whether these equations accurately reflect renal function is debated. In this Perspectives article, we discuss >70 studies that compared estimated GFR (eGFR) with measured GFR (mGFR), involving ~40,000 renal transplant recipients and patients with chronic kidney disease (CKD), type 2 diabetes mellitus or polycystic kidney disease. Read More

View Article
December 2018

Randomized trial of intravenous iron-induced hypophosphatemia.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

AMAG Pharmaceuticals, Inc., Waltham, Massachusetts, USA.

Background: Hypophosphatemia can complicate intravenous iron therapy, but no head-to-head trials compared the effects of newer intravenous iron formulations on risks and mediators of hypophosphatemia.

Methods: In a randomized, double-blinded, controlled trial of adults with iron deficiency anemia from February 2016 to January 2017, we compared rates of hypophosphatemia in response to a single FDA-approved course of ferric carboxymaltose (n = 1,000) or ferumoxytol (n = 997). To investigate pathophysiological mediators of intravenous iron-induced hypophosphatemia, we nested within the parent trial a physiological substudy (ferric carboxymaltose, n = 98; ferumoxytol, n = 87) in which we measured fibroblast growth factor 23 (FGF23), calcitriol, and parathyroid hormone (PTH) at baseline and 1, 2, and 5 weeks later. Read More

View Article
December 2018
2 Reads

Inhibition of stromal cell-derived factor-1α/CXCR4 signaling restores the blood-retina barrier in pericyte-deficient mouse retinas.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Animal Radiology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.

In diabetic retinopathy (DR), pericyte dropout from capillary walls is believed to cause the breakdown of the blood-retina barrier (BRB), which subsequently leads to vision-threatening retinal edema. While various proinflammatory cytokines and chemokines are upregulated in eyes with DR, their distinct contributions to disease progression remain elusive. Here, we evaluated roles of stromal cell-derived factor-1α (SDF-1α) and its receptor CXCR4 in the BRB breakdown initiated by pericyte deficiency. Read More

View Article
December 2018

How common are neurocognitive disorders in patients with chronic kidney disease and diabetes? Results from a cross-sectional study in a community cohort of patients in North Wales, UK.

BMJ Open 2018 Dec 4;8(12):e023520. Epub 2018 Dec 4.

Department of Nephrology, Betsi Cadwaladr University Health Board, Rhyl, UK.

Objective: Chronic kidney disease (CKD) affects nearly 9% of global populations and is strongly associated with older age. Neurocognitive disorders (NCDs), which include mild cognitive impairment and dementia, are rising as a result of ageing populations throughout the world. This investigation's aim is to report the frequency of mild to major NCD in a clinical cohort of adults with mild to moderate CKD and diabetes. Read More

View Article
December 2018

Cumulative network-meta-analyses, practice guidelines and actual prescriptions of drug treatments for postmenopausal osteoporosis: a study protocol for cumulative network meta-analyses and meta-epidemiological study.

BMJ Open 2018 Dec 4;8(12):e023218. Epub 2018 Dec 4.

Department of Health Promotion and Human Behavior, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Cumulative network meta-analysis (NMA) is a method to provide a global comparison of multiple treatments with real-time update to evidence users. Several studies investigated the ranking of cumulative NMA and the recommendations of practice guidelines. However, to the best of our knowledge, no study has evaluated the cumulative NMA ranking and prescription patterns. Read More

View Article
December 2018
1 Read

T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: T cell dysfunction occurs in many diseases, especially in chronic virus infection and cancers. However, up to now, little is known on the distinctions in T cell exhaustion between cancer and chronic virus infection. The objective of this study is to explore the transcriptional similarities and differences in exhausted CD8 +T cell between chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Read More

View Article
December 2018

microRNA expression pattern as an ancillary prognostic signature for radiotherapy.

J Transl Med 2018 Dec 5;16(1):341. Epub 2018 Dec 5.

Department of Biomedical Sciences and Engineering, Institute of Systems Biology and Bioinformatics, National Central University, Taoyuan, Taiwan.

Background: In view of the limited knowledge of plasma biomarkers relating to cancer resistance to radiotherapy, we have set up screening, training and testing stages to investigate the microRNAs (miRNAs) expression profile in plasma to predict between the poor responsive and responsive groups after 6 months of radiotherapy.

Methods: Plasma was collected prior to and after radiotherapy, and the microRNA profiles were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) arrays. Candidate miRNAs were validated by single qRT-PCR assays from the training and testing set. Read More

View Article
December 2018
1 Read

Virus- and cell type-specific effects in orthohantavirus infection.

Virus Res 2018 Nov 30. Epub 2018 Nov 30.

Department of Nephrology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Orthohantaviruses Hantaan (HTNV) and Puumala (PUUV) virus cause hemorrhagic fever with renal syndrome (HFRS), that is characterized by acute renal failure with often massive proteinuria and by morphological changes of the tubular and glomerular apparatus. Orthohantaviral N protein is found in renal cells and plays a key role in replication. However, the replication in human renal cells is not well characterized. Read More

View Article
November 2018
1 Read

Protein-energy wasting and asymmetric dimethylarginine in peritoneal dialysis patients.

Acta Biochim Pol 2018 Dec 3. Epub 2018 Dec 3.

Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdańsk, Poland.

Cardiovascular (CVS) morbidity and mortality in the peritoneal dialysis patients (PD) is 10-30-fold higher than in the general population. A relatively low level of adiponectin and a higher level of leptin are important predictors of vascular complications as well as CVS events in PD patients. The asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is an important risk factor of CVS morbidity and mortality. Read More

View Article
December 2018
2 Reads

High Glucose Alters Fetal Rat Islet Transcriptome and Induces Progeny Islet Dysfunction.

J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

K Kua, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, United States.

Offspring of diabetic mothers are susceptible to developing type 2 diabetes due to pancreatic islet dysfunction. However, the initiating molecular pathways leading to offspring pancreatic islet dysfunction are unknown. We hypothesized that maternal hyperglycemia alters offspring pancreatic islet transcriptome and negatively impacts offspring islet function. Read More

View Article
December 2018

Efficacy of dual antiplatelet therapy for preventing recurrence of arterial thrombosis in patients with antiphospholipid syndrome.

Rheumatology (Oxford) 2018 Nov 30. Epub 2018 Nov 30.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Objective: Warfarin is regarded as the standard treatment for preventing thrombotic events in APS, but the recurrence rate is still high. Dual antiplatelet therapy (DAPT) has been shown to be effective for the prevention of acute coronary syndrome or stroke. The objective of this study was to evaluate the efficacy of DAPT for the prevention of thrombosis recurrence in APS patients with history of arterial thrombosis. Read More

View Article
November 2018

Metagenomic virome sequencing in living donor-recipient kidney transplant pairs revealed JC Polyomavirus transmission.

Clin Infect Dis 2018 Dec 2. Epub 2018 Dec 2.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

Background: Before kidney transplantation, donors and recipients are routinely screened for viral pathogens using specific tests. Little is known about unrecognized viruses of the urinary tract that potentially result in transmission. Using an open metagenomic approach, we aimed to comprehensively assess virus transmission in living donor kidney transplantation. Read More

View Article
December 2018
2 Reads

Fasting blood glucose is predictive of hypertension in a general Japanese population.

J Hypertens 2019 Jan;37(1):167-174

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

Objective: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design.

Methods: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. Read More

View Article
January 2019
2 Reads

Development of a predictive model using endoscopic features for gastric cytomegalovirus infection in renal transplant patients.

Transplantation 2018 Nov 30. Epub 2018 Nov 30.

Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Background: Cytomegalovirus (CMV) is a common viral pathogen in transplant patients that often targets the stomach. However, the endoscopic characteristics of gastric CMV infection are not well established. We aimed to develop a predictive model using endoscopic findings for gastric CMV infection in renal transplant patients. Read More

View Article
November 2018

Subclinical Antibody Mediated Rejection after Kidney Transplantation: Treatment Outcomes.

Transplantation 2018 Nov 30. Epub 2018 Nov 30.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Background: Antibody-mediated rejection (ABMR) is a leading cause of morbidity and mortality after kidney transplantation. Early diagnosis and treatment of subclinical ABMR based on the donor-specific antibody (DSA) testing may result in better outcomes.

Methods: We tested this hypothesis in 220 kidney transplant recipients who underwent an indication or DSA-based surveillance protocol biopsies between 03/01/2013 and 12/31/2016. Read More

View Article
November 2018

Measuring alloantibodies: a matter of quantity and quality.

Curr Opin Organ Transplant 2018 Nov 30. Epub 2018 Nov 30.

Regional HLA Laboratory, Laboratory Medicine Program, University Health Network.

Purpose Of Review: This review is intended to describe both the usefulness and limitations of mean fluorescence intensity (MFI) as a semiquantitative measure for assessing the presence, relative strength, and clinical impact of human leukocyte antigen (HLA) alloantibodies, as well as the other qualitative features of antibodies that are important considerations in assessing patient risk.

Recent Findings: Using MFI as a quantitative measure is complicated by procedural variation between HLA laboratories. Standardized serum manipulations such as EDTA treatment or serum dilution results in better definition of relationships between MFI and antibody titer or complement activation, bringing the HLA community closer to consensus regarding strategies for defining positivity. Read More

View Article
November 2018

Bacterial sepsis triggers an antiviral response that causes translation shutdown.

J Clin Invest 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine.

In response to viral pathogens, the host upregulates antiviral genes that suppress translation of viral mRNAs. However, induction of such antiviral responses may not be exclusive to viruses, as the pathways lie at the intersection of broad inflammatory networks that can also be induced by bacterial pathogens. Using a model of Gram-negative sepsis, we show that propagation of kidney damage initiated by a bacterial origin ultimately involves antiviral responses that result in host translation shutdown. Read More

View Article
December 2018

Epidemiology and Outcomes of Dengue in Kidney Transplant Recipients: A 20-year Retrospective Analysis and Comparative Literature Review.

Clin Transplant 2018 Dec 2:e13458. Epub 2018 Dec 2.

Division of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: Kidney transplant (KT) recipients in dengue-endemic areas are at risk of exposure. We investigated the epidemiology and outcomes from dengue in KT recipients at our transplant center and conducted a literature review.

Materials And Methods: We conducted a 20-year retrospective study of KT recipients who were diagnosed with laboratory-confirmed dengue from January 1997 to September 2017 according to the 2009 WHO classification. Read More

View Article
December 2018

Asymmetric dimethylarginine targets MAPK pathway to regulate insulin resistance in liver by activating inflammation factors.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Insulin resistance is associated with impaired glucose uptake and altered protein kinase B (Akt) signaling. Previous studies have suggested asymmetric dimethylarginine (ADMA) and inflammation are two distinguish factors that correlate with insulin resistance (IR). How ADMA and inflammation factors interact and synchronize in the regulation of IR in liver remain to be elucidated. Read More

View Article
December 2018

Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver Kidney Transplants.

Liver Transpl 2018 Dec 2. Epub 2018 Dec 2.

Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX.

The number of simultaneous liver kidney transplant (SLKT) and the concomitant use of induction therapy have increased over the last decade. However, there is little data comparing outcomes amongst induction agents in the context of maintenance immunosuppression regimen consisting of tacrolimus and mycophenolic acid (TAC/MPA). We queried the OPTN registry for SLKT recipients maintained on TAC/MPA at discharge in the U. Read More

View Article
December 2018

Deciphering the SUMO code in the kidney.

J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Nephrology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis. Read More

View Article
December 2018

Childhood IgA Nephropathy Successfully Treated with Targeted-Release Budesonide: A Case Report.

J Paediatr Child Health 2018 Dec;54(12):1403

Department of Nephrology, Perth Children's Hospital, Australia.

View Article
December 2018