127,076 results match your criteria Nephrology Carlton Vic.[Journal]


Targeting PPARα for the Treatment and Understanding of Cardiovascular Diseases.

Cell Physiol Biochem 2018 Dec 12;51(6):2760-2775. Epub 2018 Dec 12.

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα, PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although the roles of these PPARs and their agonists/antagonists were defined in clinical and basic studies, the conflicting results from these studies indicate that more analysis is needed to understand the roles of PPARs. PPARα is a ligand-activated transcription factor that contributes to the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. Read More

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http://dx.doi.org/10.1159/000495969DOI Listing
December 2018

Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 15. Epub 2018 Dec 15.

Dept. of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China; Center of Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address:

Acute kidney injury (AKI) is a frequent complication of sepsis and contributes to increased morbidity and mortality. Urinary tissue inhibitor of metalloproteinases-2 (TIMP2) has been recently recognized as an early biomarker to predict AKI in critically ill patients. However, the biological functions of TIMP2 remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.10.041DOI Listing
December 2018

Renal transplantation and predisposition to opportunistic infections.

Curr Opin Pediatr 2018 Dec 17. Epub 2018 Dec 17.

Division of Pediatric Nephrology, Hypertension and Pheresis, Washington University School of Medicine and St Louis Children's Hospital, St. Louis.

Purpose Of Review: Infections represent a significant source of morbidity and mortality after kidney transplantation in children. We review recent advances in epidemiology, assessment, prevention and treatment for several different infections.

Recent Findings: Infections, such as bacterial urinary tract infection or opportunistic viral infection remain common, may be increasing and represent a large proportion of hospitalization. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000728DOI Listing
December 2018

Labetalol or Amphetamine: A Case of Mistaken Identity With Clinical Consequence.

Am J Ther 2018 Dec 11. Epub 2018 Dec 11.

Division of Cardiology, Westchester Medical Center and New York Medical College, Valhalla, NY.

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http://dx.doi.org/10.1097/MJT.0000000000000901DOI Listing
December 2018

Sex disparities in clinical characteristics and prognosis of immunoglobulin G4-related disease: a prospective study of 403 patients.

Rheumatology (Oxford) 2018 Dec 17. Epub 2018 Dec 17.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing.

Objectives: To study the impact of sex on the clinical presentation of IgG4-related disease (IgG4-RD).

Methods: We prospectively enrolled 403 newly diagnosed IgG4-RD patients. We compared the demographic features, clinical manifestations, organ involvement, laboratory tests and treatment outcomes between female and male patients. Read More

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http://dx.doi.org/10.1093/rheumatology/key397DOI Listing
December 2018

Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients.

Nephrol Dial Transplant 2018 Dec 15. Epub 2018 Dec 15.

Radboud Institute for Health Sciences, Department of Nephrology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Few studies have evaluated the effect of different immunosuppressive strategies on long-term kidney transplant outcomes. Moreover, as they were usually based on historical data, it was not possible to account for the presence of pretransplant donor-specific human-leukocyte antigen antibodies (DSA), a currently recognized risk marker for impaired graft survival. The aim of this study was to evaluate to what extent frequently used initial immunosuppressive therapies increase graft survival in immunological low-risk patients. Read More

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http://dx.doi.org/10.1093/ndt/gfy377DOI Listing
December 2018

The effect of maintaining high hemoglobin levels on long-term kidney function in kidney transplant recipients: a randomized controlled trial.

Nephrol Dial Transplant 2018 Dec 17. Epub 2018 Dec 17.

Department of Transplant Nephrology and Surgery, Kidney Disease Center, Nagoya Daini Red Cross Hospital, Nagoya, Japan.

Background: Posttransplant anemia may be a major determinant of chronic allograft nephropathy. However, the impact of correcting anemia on graft function remains controversial.

Methods: A 3-year follow-up of an open-label, multicenter, randomized controlled trial involving kidney transplantation recipients examined whether sustained maintenance of target hemoglobin (Hb) concentrations at a high level (12. Read More

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http://dx.doi.org/10.1093/ndt/gfy365DOI Listing
December 2018

Differences in peritoneal dialysis technique survival between patients treated with peritoneal dialysis systems from different companies.

Nephrol Dial Transplant 2018 Dec 14. Epub 2018 Dec 14.

Australia and New Zealand Dialysis and Transplant Registry, Adelaide, SA, Australia.

Background: A number of peritoneal dialysis (PD) systems are available but there have been few studies comparing them. The aim of this study was to examine technique failure and patient survival between different PD company systems.

Methods: The study included all patients who commenced PD between 1995 and 2014 in Australia and New Zealand. Read More

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http://dx.doi.org/10.1093/ndt/gfy340DOI Listing
December 2018

Retinal Vasculopathy With Cerebral Leukodystrophy: Clinicopathologic Features of an Autopsied Patient With a Heterozygous TREX 1 Mutation.

J Neuropathol Exp Neurol 2018 Nov 17. Epub 2018 Nov 17.

Department of Pathology.

Retinal vasculopathy with cerebral leukodystrophy (RVCL) is an autosomal-dominant disorder involving the cerebral, retinal, renal, and other systemic microvessels due to frameshift mutations in the TREX1 gene. Under physiological conditions, the TREX1 protein is localized in the cellular cytoplasm and perinuclear area, but translocates into the nucleus in response to oxidative DNA damage. It has been speculated that aberrant localization of the protein may be associated with systemic microangiopathy in patients with RVCL. Read More

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http://dx.doi.org/10.1093/jnen/nly115DOI Listing
November 2018

Hemolytic uremic syndrome: differential diagnosis with the onset of inflammatory bowel diseases.

Acta Biomed 2018 Dec 17;89(9-S):153-157. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background: Shiga-toxin Escherichia coli productor (STEC) provokes frequently an important intestinal damage that may be considered in differential diagnosis with the onset of Inflammatory Bowel Disease (IBD). The aim of this work is to review in the current literature about Hemolytic Uremic Syndrome (HUS) and IBD symptoms at the onset, comparing the clinical presentation and symptoms, as the timing of diagnosis and of the correct treatment of both these conditions is a fundamental prognostic factor. A focus is made about the association between typical or atypical HUS and IBD and a possible renal involvement in patient with IBD (IgA-nephropathy). Read More

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December 2018

Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.

Acta Biomed 2018 Dec 17;89(9-S):76-80. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background And Aim Of The Work: Historical studies have demonstrated that the prevalence of symptomatic nephrolithiasis is higher in patients with inflammatory bowel disease (IBD), compared to general population. The aim of the review was to analyze literature data in order to identify the main risk conditions described in literature and the proposed treatment.

Methods: A research on the databases PubMed, Medline, Embase and Google Scholar was performed by using the keywords "renal calculi/lithiasis/stones" and "inflammatory bowel diseases". Read More

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December 2018

Ezetimibe in Combination With Simvastatin Reduces Remnant Cholesterol Without Affecting Biliary Lipid Concentrations in Gallstone Patients.

J Am Heart Assoc 2018 Dec;7(24):e009876

4 Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme Karolinska University Hospital Stockholm Sweden.

Background In randomized trials (SHARP [Study of Heart and Renal Protection], IMPROVE -IT [Improved Reduction of Outcomes: Vytorin Efficacy International Trial]), combination of statin and ezetimibe resulted in additional reduction of cardiovascular events. The reduction was greater in patients with type 2 diabetes mellitus (T2 DM ), where elevated remnant cholesterol and high cardiovascular disease risk is characteristic. To evaluate possible causes behind these results, 40 patients eligible for cholecystectomy, randomized to simvastatin, ezetimibe, combined treatment (simvastatin+ezetimibe), or placebo treatment during 4 weeks before surgery, were studied. Read More

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http://dx.doi.org/10.1161/JAHA.118.009876DOI Listing
December 2018

Effects of probiotic supplements on the progression of chronic kidney disease: a meta-analysis.

Nephrology (Carlton) 2018 Dec 18. Epub 2018 Dec 18.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China.

Background: Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here we performed a meta-analysis to assess the effects of probiotic supplements on the CKD progression. Read More

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http://dx.doi.org/10.1111/nep.13549DOI Listing
December 2018

Evaluation of the impact of conventional immunosuppressant on the establishment of murine transplantation tolerance - an experimental study.

Transpl Int 2018 Dec 17. Epub 2018 Dec 17.

Department of Urology, Tokyo Women's Medical University, Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Regulatory T cells (Tregs) play a significant role in immune tolerance. Since Treg function deeply depends on Interleukin-2 signaling, calcineurin inhibitors could affect their suppressive potentials, whereas mammalian target of rapamycin (mTOR) inhibitors may have less impact, as mTOR signaling is not fundamental to Treg proliferation. We previously reported a novel mixed hematopoietic chimerism induction regimen that promotes Treg proliferation by stimulating invariant natural killer T cells under CD40 blockade. Read More

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http://dx.doi.org/10.1111/tri.13390DOI Listing
December 2018

Sarcopenia Index Is a Simple Objective Screening Tool for Malnutrition in the Critically Ill.

JPEN J Parenter Enteral Nutr 2018 Dec 18. Epub 2018 Dec 18.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Background: Reliable and valid tools to screen for malnutrition in the intensive care unit (ICU) remain elusive. The sarcopenia index (SI) [(serum creatinine/serum cystatin C) × 100], could be an inexpensive, objective tool to predict malnutrition. We evaluated the SI as a screening tool for malnutrition in the ICU and compared it with the modified-NUTRIC score. Read More

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http://dx.doi.org/10.1002/jpen.1492DOI Listing
December 2018

Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease.

Sci Rep 2018 Dec 18;8(1):17926. Epub 2018 Dec 18.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

In sleep apnea syndrome (SAS), chronic intermittent hypoxia (CIH) is believed to activate the sympathetic nerve system, and is thus involved in cardiovascular diseases (CVD). However, since patients with SAS are often already obese, and have diabetes and/or hypertension (HT), the effects of CIH alone on sympathetic nerve activation and its impacts on CVD are largely unknown. We, therefore, examined the effects of CIH on sympathetic nerve activation in non-obese mice to determine whether renal sympathetic nerve denervation (RD) could ameliorate CIH-mediated cardiovascular effects. Read More

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http://dx.doi.org/10.1038/s41598-018-36159-9DOI Listing
December 2018

Pre-emptive medicine for hypertension and its prospects.

Hypertens Res 2018 Dec 18. Epub 2018 Dec 18.

Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Pre-emptive medicine is a novel medical concept proposed in Japan that aims to precisely predict the onset and progression of diseases and to provide therapeutic interventions during early stages, before symptoms appear. The concept of pre-emptive medicine considers the time-course of a disease in each individual and seeks medical interventions to prevent disease progression. Suitable and promising targets for pre-emptive medicine are non-communicable diseases, including hypertension. Read More

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http://dx.doi.org/10.1038/s41440-018-0177-3DOI Listing
December 2018

Vitamin D deficiency in patients with stages 1 and 2 chronic kidney disease in Southern China.

Niger J Clin Pract 2018 Dec;21(12):1639-1644

Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Aim: We aim to investigate the incidence and associated factors of vitamin D deficiency, a seldom reported factor, in patients with stages 1 and 2 chronic kidney disease (CKD) in southern China.

Methods: We conducted a single-center observational study. Hospitalized patients over 14 years old, who were diagnosed with stages 1 and 2 CKD and had their serum 25-hydroxyvitamin D [25 (OH) D] measured, were included. Read More

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http://dx.doi.org/10.4103/njcp.njcp_158_18DOI Listing
December 2018

Timing of renal replacement therapy initiation for acute kidney injury.

Cochrane Database Syst Rev 2018 Dec 18;12:CD010612. Epub 2018 Dec 18.

Pediatric Nephrology, Ricardo Gutierrez Children's Hospital, Institute for Clinical Effectiveness and Health Policy, Los Incas Av 4174, Buenos Aires, Argentina, 1427.

Background: Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs), and is associated with high death. Renal replacement therapy (RRT) is a blood purification technique used to treat the most severe forms of AKI. The optimal time to initiate RRT so as to improve clinical outcomes remains uncertain. Read More

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http://dx.doi.org/10.1002/14651858.CD010612.pub2DOI Listing
December 2018

Hepatitis C virus infection and chronic renal disease: A review.

Indian J Gastroenterol 2018 Dec 18. Epub 2018 Dec 18.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

Hepatitis C virus (HCV) is a parenterally-transmitted hepatotropic virus that often causes chronic infection, which can progress to cirrhosis and hepatocellular carcinoma. Development of highly effective direct-acting anti-viral agents (DAAs) has led to a paradigm change in the treatment of HCV infection over the last 4-5 years. Patients with chronic kidney disease (CKD) are at a higher risk of acquiring HCV infection. Read More

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http://link.springer.com/10.1007/s12664-018-0920-3
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http://dx.doi.org/10.1007/s12664-018-0920-3DOI Listing
December 2018
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ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients.

Ann Intensive Care 2018 Dec 17;8(1):127. Epub 2018 Dec 17.

Medical Intensive Care Unit, AP-HP, Saint Louis Hospital, Paris, France.

Background: Transient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality.

Design: Retrospective analysis of a prospective database via cause-specific model, with 28-day ICU mortality as primary end point, considering discharge alive as a competing event and taking into account time-dependent nature of renal recovery. Read More

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http://dx.doi.org/10.1186/s13613-018-0467-6DOI Listing
December 2018

Chronic kidney disease following twin-to-twin transfusion syndrome-long-term outcomes.

Pediatr Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

Background: Amongst other sequelae, acute kidney injury (AKI) is a well-recognised post-natal complication of twin-to-twin transfusion syndrome (TTTS). Despite this, there has been a lack of data reporting long-term renal outcomes. Our aim was to report the long-term renal outcomes of infants born with TTTS. Read More

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http://dx.doi.org/10.1007/s00467-018-4176-zDOI Listing
December 2018

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H.

Pediatr Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Pediatric Nephrology Unit, Bordeaux University Hospital, Bordeaux, France.

Background: Hemolytic uremic syndrome (HUS) has been associated with a number of infectious agents. We report here the case of an infant with severe Bordetella pertussis infection who developed HUS.

Case Diagnosis/treatment: A 2-month-old preterm male was admitted for severe Bordetella pertussis infection. Read More

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http://dx.doi.org/10.1007/s00467-018-4174-1DOI Listing
December 2018

Cystatin C and creatinine-based eGFR levels and their correlation to long-term morbidity and mortality in older adults.

Aging Clin Exp Res 2018 Dec 17. Epub 2018 Dec 17.

Department of Geriatrics, Skåne University Hospital, Jan Waldenströms gata 35, 20502, Malmö, Sweden.

Background: The prevailing diagnostic criteria for CKD are age-independent, but have been challenged in light of the eGFR decline associated with normal aging. The stages of CKD communicate magnitude of risk of ESRD, cardiovascular morbidity, and mortality.

Aims: This study aims to provide more insight into the morbidity and mortality associated with eGFR levels corresponding to the current CKD stages in older adults. Read More

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http://dx.doi.org/10.1007/s40520-018-1091-xDOI Listing
December 2018

Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging.

Eur Radiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.

Objective: To explore the value of texture analysis based on diffusion-weighted imaging (DWI), blood oxygen level-dependent MRI (BOLD), and susceptibility-weighted imaging (SWI) in evaluating renal dysfunction.

Methods: Seventy-two patients (mean age 53.72 ± 13. Read More

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http://dx.doi.org/10.1007/s00330-018-5911-3DOI Listing
December 2018

[The mechanisms and clinical potential: sodium-glucose cotransporter 2 (SGLT-2) inhibitors treating diabetic kidney disease].

Sheng Li Xue Bao 2018 Dec;70(6):663-669

Division of Nephrology, Huashan Hospital, and Nephrology Research Institute, Fudan University, Shanghai 200040, China.

The employment of sodium-glucose cotransporter 2 (SGLT-2) inhibitors in the treatment of diabetes mellitus and diabetic kidney disease (DKD) becomes a hot topic in recent years. Compared with traditional glucose-lowering drugs, SGLT-2 inhibitors present distinctive advantages in renal and cardiovascular protection. The mechanisms for renal protection include attenuating glomerular hyperfiltration, lowering serum uric acid, alleviating tubular lesions and regulating intrarenal renin-angiotensin-aldosterone system (RAAS) dysfunction. Read More

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December 2018

[Research progress of the uremic toxin indoxyl sulfate in cardiovascular complication of end-stage renal diseases].

Sheng Li Xue Bao 2018 Dec;70(6):657-662

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Cardiovascular disease is one of the most common complications and the main cause of death in patients with chronic kidney disease. Uremic toxins are the primary cause of cardiovascular disease in renal insufficiency. In patients with chronic kidney disease, the protein-bound uremic toxins represented by indoxyl sulfate are difficult to be removed by conventional dialysis and are extremely toxic. Read More

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December 2018

[Urinary biomarkers for chronic kidney disease: a focus on gene transcript].

Sheng Li Xue Bao 2018 Dec;70(6):644-648

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Chronic kidney disease (CKD) is becoming an alarming health burden worldwide, however, there is still lack of early biomarkers and effective treatment options. Thus, in the upcoming era of precision medicine, searching for the sensitive, non-invasive biomarkers has been the cornerstone and major challenge in the management of CKD. Urine contains rich biological information which could be an ideal source for non-invasive biomarkers of CKD. Read More

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December 2018

[Research update of Klotho in kidney injury and repair].

Sheng Li Xue Bao 2018 Dec;70(6):639-643

Department of Nephrology, Affiliated Hospital of Nantong University, Nantong 226001, China.

Klotho is highly expressed in the kidney, while soluble Klotho is detectable in the blood, urine, and cerebrospinal fluid, and has multiple hormone-like functions. The role of Klotho in kidney injury has attracted more and more attentions from researchers. Emerging evidence revealed that the transient deficiency of Klotho is an early event of acute kidney injury (AKI), whereas, in chronic kidney disease, this deficiency is sustained not only in the kidney, but also in other organ systems. Read More

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December 2018

[Current insights into the role of HIF-PHD axis in renal anemia].

Sheng Li Xue Bao 2018 Dec;70(6):623-629

Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Renal anemia, mainly caused by the deficiencies of erythropoietin (EPO) and iron metabolism disorder, is one of the most common complications of chronic kidney disease. Hypoxia-inducible factor (HIF) is a class of transcription factors responsible for maintaining homeostasis during oxygen deprivation. In normoxia, HIF is degraded by prolyl hydroxylase (PHD). Read More

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December 2018
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Hemolytic Uremic Syndrome Associated With O157 Infection in an Allogenic Stem Cell Transplant Recipient.

Mayo Clin Proc Innov Qual Outcomes 2018 Dec 15;2(4):387-391. Epub 2018 Sep 15.

Department of Immunology, Mayo Clinic, Rochester, MN.

We report the development of a Shiga toxin-producing O157 gastrointestinal infection associated with hemolytic uremic syndrome in an allogenic stem cell transplant recipient with a history of gastrointestinal graft-vs-host disease receiving long-term immunosuppression. Read More

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http://dx.doi.org/10.1016/j.mayocpiqo.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260488PMC
December 2018

Phytochemical screening and inhibitory activity of oxalocalcic crystallization of L. leaves.

Heliyon 2018 Dec 10;4(12):e01011. Epub 2018 Dec 10.

Laboratory of Biochemistry, Faculty of Medicine and Pharmacy, University Sidi Mohammed Ben Abdellah, BP 1893, Km 22, Road of Sidi Harazem, Fez, Morocco.

The present study is focused on the experimental verification of the efficiency of L. leaves against the crystallization of calcium oxalate. The inhibition of crystallization has been studied in vitro with the absence and the presence of the different concentrations of the infusion and hydroalcoholic extract of the plant. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e01011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290092PMC
December 2018

Chicago supermarket data and food access analytics in census tract shapefiles for 2007-2014.

Data Brief 2018 Dec 6;21:2482-2488. Epub 2018 Nov 6.

Center for Translational Metabolism and Health, Institute of Public Health & Medicine, Northwestern University, 633N. St. Clair, 18th Floor, Chicago, IL 60611, USA.

Longitudinal analysis of supermarkets over time is essential to understanding the dynamics of foodscape environments for healthy living. Supermarkets for 2007, 2011, and 2014 for the City of Chicago were curated and further validated. The average distance to all supermarkets along the street network was constructed for each resident-populated census tract. Read More

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http://dx.doi.org/10.1016/j.dib.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288981PMC
December 2018

Determining Fractional Urate Excretion Rates in Hyponatremic Conditions and Improved Methods to Distinguish Cerebral/Renal Salt Wasting From the Syndrome of Inappropriate Secretion of Antidiuretic Hormone.

Front Med (Lausanne) 2018 30;5:319. Epub 2018 Nov 30.

Division of Nephrology and Hypertension, Department of Medicine, NYU Winthrop Hospital, Mineola, NY, United States.

Our evaluation of hyponatremic patients is in a state of confusion because the assessment of the volume status of the patient and determinations of urine sodium concentrations (UNa) >30-40 mEq/L have dominated our approach despite documented evidence of many shortcomings. Central to this confusion is our inability to differentiate cerebral/renal salt wasting (C/RSW) from the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), syndromes with diametrically opposing therapeutic goals. The recent proposal to treat most or all hyponatremic patients makes differentiation even more important and reports of C/RSW occurring without cerebral disease leads to a clinically important proposal to change cerebral to renal salt wasting (RSW). Read More

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http://dx.doi.org/10.3389/fmed.2018.00319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284366PMC
November 2018

Levamisole adulterated cocaine associated ANCA vasculitis: review of literature and update on pathogenesis.

J Community Hosp Intern Med Perspect 2018 11;8(6):339-344. Epub 2018 Dec 11.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Levamisole is an antihelminth drug and a common cocaine contaminant, present in an estimated 71% of cocaine samples in the US. Levamisole-contaminated cocaine has been linked to an ANCA-associated vasculitis with cutaneous, renal, and pulmonary manifestations. We report the case of a 46 year old woman with known cocaine exposure who presents with recurrent, large purpuric and maculopapular rash of the extremities and face and review existing cases of levamisole/cocaine-associated ANCA vasculitis, We summarize the clinical presentation, treatment, and outcomes of levamisole induced vasculitis. Read More

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http://dx.doi.org/10.1080/20009666.2018.1536242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292360PMC
December 2018

The Prevalence of Risk Factors for the Development of Bacteraemia in Children.

Open Access Maced J Med Sci 2018 Nov 8;6(11):2023-2029. Epub 2018 Nov 8.

Department of Pediatric Infection Disease, Bahrami Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Aim: The objective of this study was to evaluate the frequency of risk factors for bacteremia in children less than 15 years of age was determined in Bahrami Hospital during 2013-2016.

Methods: This study conducted on 84 children aged 3 months' to15 years old, who hospitalised in the pediatrics ward and the PICU in Bahrami Hospital from 2012 to 2016. Our study consisted of 46 boys (54. Read More

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http://dx.doi.org/10.3889/oamjms.2018.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290420PMC
November 2018

Functional Prediction of Chronic Kidney Disease Susceptibility Gene PRKAG2 by Comprehensively Bioinformatics Analysis.

Front Genet 2018 3;9:573. Epub 2018 Dec 3.

Jinzhou Medical University, Jinzhou, China.

The genetic predisposition to chronic kidney disease (CKD) has been widely evaluated especially using the genome-wide association studies, which highlighted some novel genetic susceptibility variants in many genes, and estimated glomerular filtration rate to diagnose and stage CKD. Of these variants, rs7805747 in PRKAG2 was identified to be significantly associated with both serum creatinine and CKD with genome wide significance level. Until now, the potential mechanism by which rs7805747 affects CKD risk is still unclear. Read More

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http://dx.doi.org/10.3389/fgene.2018.00573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287114PMC
December 2018

miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma.

Oncogene 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiation Oncology, Arthur G. James Hospital/Ohio State Comprehensive Cancer Center, Columbus, OH, 43210, USA.

Glioblastomas (GBMs) are the most aggressive primary brain tumors, with an average survival of less than 15 months. Therefore, there is a critical need to develop novel therapeutic strategies for GBM. This study aimed to assess the prognostic value of miR-4516 and investigate its oncogenic functions and the underlying cellular and molecular mechanisms in GBM. Read More

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http://dx.doi.org/10.1038/s41388-018-0601-9DOI Listing
December 2018

Pulmonary Artery Systolic Pressure Measured Intraoperatively by Right Heart Catheterization Is a Predictor of Kidney Transplant Recipient Survival.

Ann Transplant 2018 Dec 18;23:867-873. Epub 2018 Dec 18.

Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

BACKGROUND The effect of pulmonary artery systolic pressure (PASP) measured by Swan-Ganz right heart catheter (SG-RHC) on kidney transplant recipient survival has not been previously studied. The objective of this study was to assess the relationships between PASP measured via SG-RHC, done intraoperatively at the time of initiating anesthesia at the beginning of kidney transplant surgery, and patient survival. Multiple comorbidities, time on dialysis before the transplantation, and graft function were also analyzed in our study. Read More

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http://dx.doi.org/10.12659/AOT.911176DOI Listing
December 2018

Hot topics in Fabry disease.

Postgrad Med J 2018 Dec 17. Epub 2018 Dec 17.

Department of Internal Medicine, Divisions of Nephrology and Cardiology, University Hospital Würzburg, Würzburg, Germany

Fabry disease is a rare inborn error of the enzyme α-galactosidase (α-Gal) and results in lysosomal substrate accumulation in tissues with a wide range of clinical presentations. The disease has attracted a lot of interest over the last years, in particular since enzyme replacement therapy (ERT) has become widely available in 2001. With rising awareness and rising numbers of (diagnosed) patients, physicians encounter new challenges. Read More

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http://dx.doi.org/10.1136/postgradmedj-2018-136056DOI Listing
December 2018

Should Canadian medical schools have trainees funded by Saudi Arabia?

CMAJ 2018 Dec;190(50):E1485

Associate professor, Division of Nephrology, Department of Medicine, Queen's University, Kingston, Ont.

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http://dx.doi.org/10.1503/cmaj.70797DOI Listing
December 2018

Projecting ESRD Incidence and Prevalence in the United States through 2030.

J Am Soc Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Arbor Research Collaborative for Health, Ann Arbor, Michigan; and Departments of.

Background: Population rates of obesity, hypertension, diabetes, age, and race can be used in simulation models to develop projections of ESRD incidence and prevalence. Such projections can inform long-range planning for ESRD resources needs.

Methods: We used an open compartmental simulation model to estimate the incidence and prevalence of ESRD in the United States through 2030 on the basis of wide-ranging projections of population obesity and ESRD death rates. Read More

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http://dx.doi.org/10.1681/ASN.2018050531DOI Listing
December 2018

Good Guys, Bad Guys, Guesses, and Near Misses in Nephrology.

Clin J Am Soc Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Division of Nephrology, Department of Medicine and

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http://dx.doi.org/10.2215/CJN.13801118DOI Listing
December 2018

Effects of Dapagliflozin on Circulating Markers of Phosphate Homeostasis.

Clin J Am Soc Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Division of Nephrology, and Departments of Internal Medicine and

Background And Objectives: The sodium glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin is a novel drug for the treatment of diabetes mellitus. Recent studies suggest that SGLT-2 inhibitors affect phosphate homeostasis, but their effects on phosphate-regulating hormones in patients with diabetic kidney disease are still unclear.

Design, Setting, Participants, & Measurements: We performed a analysis of a double-blind, randomized, crossover trial in patients with type 2 diabetes with early-stage diabetic kidney disease on stable renin-angiotensin-aldosterone system blockade, with an albumin-to-creatinine ratio between 100 and 3500 mg/g, eGFR≥45 ml/min per 1. Read More

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http://dx.doi.org/10.2215/CJN.04530418DOI Listing
December 2018

Effects of Molidustat in the Treatment of Anemia in Chronic Kidney Disease.

Clin J Am Soc Nephrol 2018 Dec 17. Epub 2018 Dec 17.

Departments of Research and Development, and Pharmaceuticals, Bayer AG, Wuppertal, Germany.

Background And Objectives: The efficacy and safety of molidustat, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, have been evaluated in three 16-week, phase 2b studies in patients with CKD and anemia who are not on dialysis (DaIly orAL treatment increasing endOGenoUs Erythropoietin [DIALOGUE] 1 and 2) and in those who are on dialysis (DIALOGUE 4).

Design, Setting, Participants, & Measurements: DIALOGUE 1 was a placebo-controlled, fixed-dose trial (25, 50, and 75 mg once daily; 25 and 50 mg twice daily). DIALOGUE 2 and 4 were open-label, variable-dose trials, in which treatment was switched from darbepoetin (DIAGLOGUE 2) or epoetin (DIALOGUE 4) to molidustat or continued with the original agents. Read More

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http://dx.doi.org/10.2215/CJN.02510218DOI Listing
December 2018

Pre-eclampsia Educational Tool Impact on Knowledge, Anxiety, and Satisfaction in Pregnant Women: A Randomized Trial.

J Obstet Gynaecol Can 2018 Dec 14. Epub 2018 Dec 14.

Division of Internal Medicine, Centre Hospitalier Universitaire de Sherbrooke, University of Sherbrooke, Sherbrooke, QC. Electronic address:

Objective: This study aimed to evaluate the impact of educational tools concerning pre-eclampsia on knowledge, anxiety, and women's satisfaction.

Methods: The investigators conducted an RCT from March to July 2014 at the Centre Hospitalier Universitaire de Sherbrooke (Sherbrooke, QC) by comparing ambulatory pregnant women (20-32 weeks of gestation) who were receiving educational tools on pre-eclampsia with control subjects who received routine care. Tools consisted of an informative pamphlet, a video, and a pictographic magnet, all validated by a multidisciplinary team. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.10.003DOI Listing
December 2018

Role of Lung Ultrasound in Adjusting Ultrafiltration Volume in Hemodialysis Patients.

Ultrasound Med Biol 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Ultrasonics, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China. Electronic address:

Chronic fluid over-hydration is common in dialysis patients. It is associated with mortality and cardiovascular events. Optimal methods for adjusting fluid volume status and ideal dry weight remain uncertain. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.10.025DOI Listing
December 2018

The role of an electronic alert system to detect acute kidney injury in hospitalized patients: DETECT-H Project.

Nefrologia 2018 Dec 14. Epub 2018 Dec 14.

International Renal Research Institute of Vicenza (IRRIV), Vicenza, Italy; Department of Nephrology Dialysis & Transplantation, San Bortolo Hospital, Vicenza, Italy.

Background And Aims: Acute kidney injury (AKI) is associated with higher mortality and length of stay (LOS) for hospitalized patients. To improve outcomes, an electronic detection system could be a useful tool for early diagnosis.

Methods: A fully automated real-time system for detecting decreased glomerular filtration rate in adult patients was developed in our hospital, DETECT-H project. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.08.011DOI Listing
December 2018

Galloway-Mowat syndrome in Taiwan: OSGEP mutation and unique clinical phenotype.

Orphanet J Rare Dis 2018 Dec 17;13(1):226. Epub 2018 Dec 17.

Department of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Chung-Shan North Road, Taipei, Taiwan.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disease characterized by the combination of glomerulopathy with early-onset nephrotic syndrome and microcephaly with central nervous system anomalies. Given its clinical heterogeneity, GAMOS is believed to be a genetically heterogenous group of disorders. Recently, it has been reported that mutations in KEOPS-encoding genes, including the OSGEP gene, were responsible for GAMOS. Read More

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http://dx.doi.org/10.1186/s13023-018-0961-9DOI Listing
December 2018