129,417 results match your criteria Nephrology Carlton Vic.[Journal]


Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice.

Nanomedicine 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea. Electronic address:

The aggregation and accumulation of amyloid beta (Aβ) peptide is believed to be the primary cause of Alzheimer's disease (AD) pathogenesis. Vitamin D-binding protein (DBP) can attenuate Aβ aggregation and accumulation. A biocompatible polymer poly (-lactic acid-co-glycolic acid) (PLGA) can be loaded with therapeutic agents and control the rate of their release. Read More

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http://dx.doi.org/10.1016/j.nano.2019.02.004DOI Listing
February 2019

Increased CD16 expression on NK cells is indicative of antibody-dependent cell-mediated cytotoxicity in chronic-active antibody-mediated rejection.

Transpl Immunol 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands.

Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. The antibodies directed against donor-derived antigens, e.g. Read More

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http://dx.doi.org/10.1016/j.trim.2019.02.005DOI Listing
February 2019

Intrinsic Bone Defects in Cystinotic Mice.

Am J Pathol 2019 Feb 19. Epub 2019 Feb 19.

Bone Physiopathology Group, Multifactorial Disease and Complex Phenotype Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

Cystinosis is a rare lysosomal storage disorder caused by loss of function mutations of the CTNS gene, encoding cystinosin, a symporter that mediates cystine efflux from lysosomes. About 95% of patients with cystinosis display renal Fanconi syndrome, short stature, osteopenia, and rickets . In this study, we investigated whether the absence of cystinosin primarily affects bone remodeling activity, apart from the influences of the Fanconi syndrome on bone mineral metabolism. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.01.015DOI Listing
February 2019

Avascular osteonecrosis in kidney transplant recipients: Risk factors in a recent cohort study and evaluation of the role of secondary hyperparathyroidism.

PLoS One 2019 22;14(2):e0212931. Epub 2019 Feb 22.

Department of Rheumatology, University Hospital, Strasbourg, France.

Avascular osteonecrosis (AVN) is a bone complication that indicates poor functional prognosis. Modern immunosuppressive and steroid-sparing drugs have significantly lowered the occurrence of AVN after kidney transplantation (KT). However, recent data on its incidence rates and risk factors are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212931PLOS
February 2019

Association between circulating mononuclear cell mitochondrial DNA copy number and in-hospital mortality in septic patients: A prospective observational study based on the Sepsis-3 definition.

PLoS One 2019 22;14(2):e0212808. Epub 2019 Feb 22.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang Province; The Third Grade Laboratory under the National State, Administration of Traditional Chinese Medicine, Hangzhou, China.

Purpose: To explore the association between circulating mononuclear cell mitochondrial DNA copy number and the prognosis of sepsis patients based on the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3 definition).

Methods: A total of 200 adult patients who had recently devoloped sepsis were prospectively recruited as the study cohort. Demographic and clinical data were recorded along with a 28-day outcome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212808PLOS
February 2019

Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.

PLoS One 2019 22;14(2):e0212818. Epub 2019 Feb 22.

Department of Nephrology, Ajou University School of Medicine, Suwon, Korea.

Background: Growth Arrest and DNA Damage 45γ (GADD45γ) is a member of the DNA damage-inducible gene family which responds to environmental stresses. Apoptosis is a critical mode of renal tubular cell death in nephrotoxin-induced acute kidney injury. In this study, we investigated the role of GADD45γ in renal tubular cell apoptosis induced by nephrotoxic drugs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212818PLOS
February 2019

Effects of high-volume online mixed-hemodiafiltration on anemia management in dialysis patients.

PLoS One 2019 22;14(2):e0212795. Epub 2019 Feb 22.

Fresenius Medical Care Deutschland GmbH, Clinical &Therapeutical Governance, Bad Homburg, Germany.

Background: Anemia is a major comorbidity of patients with end-stage renal disease and poses an enormous economic burden to health-care systems. High dose erythropoiesis-stimulating agents (ESAs) have been associated with unfavorable clinical outcomes. We explored whether mixed-dilution hemodiafiltration (Mixed-HDF), based on its innovative substitution modality, may improve anemia outcomes compared to the traditional post-dilution hemodiafiltration (Post-HDF). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212795PLOS
February 2019

Pancreatic autoantibodies and CD14+CD16+ monocytes subset are associated with the impairment of ß-cell function after simultaneous pancreas-kidney transplantation.

PLoS One 2019 22;14(2):e0212547. Epub 2019 Feb 22.

Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain.

Pancreatic autoantibodies (AAb) has been associated with a worse pancreas graft survival after simultaneous pancreas-kidney transplantation (SPK). However, due to the variable time for AAb to become positive and the lack of early biomarkers suggesting such autoimmune activation, the mechanisms leading ß-cell destruction remain uncertain. The present study aimed to evaluate the association between post-transplant AAb and the functional impairment of the pancreatic ß-cell and also the association of such AAb with inflammation after SPK. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212547PLOS
February 2019

Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression.

PLoS One 2019 22;14(2):e0212254. Epub 2019 Feb 22.

General Teaching Hospital, 1st Faculty of Medicine, Charles University, Department of Nephrology, Prague, Czech Republic.

Background: IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has serious outcomes with end-stage renal disease developing in 30-50% of patients. The diagnosis requires renal biopsy. Due to its inherent risks, non-invasive approaches are needed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212254PLOS
February 2019
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Implications of Classification of Os Trigonum: A Study Based on Computed Tomography Three-Dimensional Imaging.

Med Sci Monit 2019 Feb 22;25:1423-1428. Epub 2019 Feb 22.

Department of Orthopedic, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The os trigonum is an accessory bone that is not fully fused with the talus during secondary ossification, and is one of the risk factors of posterior malleolus impact syndrome. The purpose of this study was to classify the os trigonum and to guide the diagnosis and treatment of related clinical diseases. MATERIAL AND METHODS Ankle computed tomography (CT) scans of 586 Chinese patients between October 2014 and October 2018 were reviewed. Read More

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http://dx.doi.org/10.12659/MSM.914485DOI Listing
February 2019

Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions.

Aging Cell 2019 Feb 22:e12850. Epub 2019 Feb 22.

U995 - Lille Inflammation Research International Center, INSERM, CHU Lille, University of Lille, Lille, France.

Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). The role of dietary AGEs in aging remains ill-defined, but the predominantly renal accumulation of dietary carboxymethyllysine (CML) suggests the kidneys may be particularly affected. We studied the impact of RAGE invalidation and a CML-enriched diet on renal aging. Read More

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http://dx.doi.org/10.1111/acel.12850DOI Listing
February 2019

Care Transitions Program for High-Risk Frail Older Adults is Most Beneficial for Patients with Cognitive Impairment.

J Hosp Med 2019 Feb 20;14:E1-E8. Epub 2019 Feb 20.

Division of Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Although posthospitalization care transitions programs (CTP) are highly diverse, their overall program thoroughness is most predictive of their success.

Objective: To identify components of a successful homebased CTP and patient characteristics that are most predictive of reduced 30-day readmissions.

Design: Retrospective cohort. Read More

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http://dx.doi.org/10.12788/jhm.3112DOI Listing
February 2019

Updates in Management and Timing of Dialysis in Acute Kidney Injury.

J Hosp Med 2019 Feb 20;14:E1-E7. Epub 2019 Feb 20.

Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California.

Acute kidney injury (AKI) is a common complication in hospitalized patients and is associated with mortality, prolonged hospital length of stay, and increased healthcare costs. This paper reviews several areas of controversy in the identification and management of AKI. Serum creatinine and urine output are used to identify and stage AKI by severity. Read More

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http://dx.doi.org/10.12788/jhm.3105DOI Listing
February 2019

Incidence rate of atrial fibrillation after dialysis initiation and its relationship with cardiovascular events.

Acta Cardiol 2019 Feb 22:1-9. Epub 2019 Feb 22.

a Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital , Nagoya , Japan.

Aim: This study aimed to investigate the incidence of atrial fibrillation (AF) and its prognosis in the patients after dialysis initiation.

Methods: A total of 1524 patients with chronic kidney disease who were initiated on dialysis were included. Dialysis was initiated between October 2011 and September 2013. Read More

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http://dx.doi.org/10.1080/00015385.2018.1530085DOI Listing
February 2019

ASSOCIATION BETWEEN RANDALL'S PLAQUE STONE ANCHORS AND RENAL PAPILLARY PITS.

J Endourol 2019 Feb 22. Epub 2019 Feb 22.

Indiana University School of Medicine, Dept. of Urology , 1801 North Senate Blvd. , Suite 220 , Indianapolis, Indiana, United States , 46202 ;

Introduction: Renal papillary pits are commonly encountered during ureteroscopy. The mechanism by which such pits arise is unclear. One hypothesis is that pits represent sites where stones overgrowing Randall's plaque (RP) were dislodged. Read More

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http://dx.doi.org/10.1089/end.2018.0589DOI Listing
February 2019

Acid-sensing ion channel 1a is involved in ischaemia/reperfusion induced kidney injury by increasing renal epithelia cell apoptosis.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Acidic microenvironment is commonly observed in ischaemic tissue. In the kidney, extracellular pH dropped from 7.4 to 6. Read More

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http://dx.doi.org/10.1111/jcmm.14238DOI Listing
February 2019

Inhibition of P53/miR-34a improves diabetic endothelial dysfunction via activation of SIRT1.

J Cell Mol Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, Jinan, Shandong, China.

Endothelial dysfunction contributes to diabetic macrovascular complications, resulting in high mortality. Recent findings demonstrate a pathogenic role of P53 in endothelial dysfunction, encouraging the investigation of the effect of P53 inhibition on diabetic endothelial dysfunction. Thus, high glucose (HG)-treated endothelial cells (ECs) were subjected to pifithrin-α (PFT-α)-a specific inhibitor of P53, or P53-small interfering RNA (siRNA), both of which attenuated the HG-induced endothelial inflammation and oxidative stress. Read More

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http://dx.doi.org/10.1111/jcmm.14253DOI Listing
February 2019

Effects of valsartan, benazepril and their combination in overt nephropathy of type 2 diabetes: A prospective, randomized, controlled trial.

Diabetes Obes Metab 2019 Feb 22. Epub 2019 Feb 22.

Department of Renal Medicine, Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò": Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (Bergamo), Italy.

Aims: To evaluate whether angiotensin-converting enzyme (ACE) inhibitor and angiotensin II receptor blocker (ARB) combination therapy is more nephroprotective than ACE inhibitor or ARB monotherapy in people with type 2 diabetes and overt nephropathy.

Materials And Methods: In this prospective, randomized, open, blind-endpoint phase III trial sponsored by the Italian Drug Agency, 103 consenting patients with type 2 diabetes, aged >40 years, with serum creatinine levels 159 to 309 μmol/L, spot morning urinary albumin-creatinine ratio > 1000 mg/g (or > 500 mg/g in those on ACE inhibitor or ARB therapy at inclusion) were stratified by centre and randomized to 4.5-year treatment with valsartan 320 mg/d (n = 36), benazepril 20 mg/d (n = 34) or halved doses of both medications (n = 33). Read More

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http://dx.doi.org/10.1111/dom.13639DOI Listing
February 2019

Expanding analytic possibilities in pediatric solid organ transplantation through linkage of administrative and clinical registry databases.

Pediatr Transplant 2019 Feb 21:e13379. Epub 2019 Feb 21.

Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, Tennessee.

Database linkage is a common strategy to expand analytic possibilities. Our group recently completed a linkage between the SRTR and PHIS databases for pediatric heart transplant recipients. The aim of this project was to expand the linkage between SRTR and PHIS to include liver, kidney, lung, heart-lung, and small bowel transplants. Read More

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http://dx.doi.org/10.1111/petr.13379DOI Listing
February 2019

Combined Liver-Kidney Transplantation (CLKT) versus Liver Transplant alone (LTA) based on KDIGO stratification of estimated glomerular filtration rate (eGFR): Data from the United Kingdom Transplant Registry - a retrospective cohort study.

Transpl Int 2019 Feb 21. Epub 2019 Feb 21.

The Liver Unit Queen Elizabeth Hospital BirminghamUnited Kingdom.

Patient selection for combined liver-kidney transplantation (CLKT) is a current issue on the background of organ shortage. This study aimed to compare outcomes and post-transplant renal function for patients receiving CLKT and liver transplantation alone (LTA) based on native renal function using eGFR stratification. Using the UK National transplant database (NHSBT) 6035 patients receiving a LTA (N=5912; 98%) or CLKT (N=123; 2%) [2001-2013] were analysed, and stratified by KDIGO stages of eGFR at transplant (eGFR group-strata). Read More

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http://dx.doi.org/10.1111/tri.13413DOI Listing
February 2019

Kidney Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity.

Transpl Int 2019 Feb 21. Epub 2019 Feb 21.

Organ Transplantation Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Inflammatory Bowel Diseases (IBD) is a systemic disorder with possible renal involvement, yet data regarding the outcome of kidney transplantation (KT) in those patients, and IBD course post KT, are scarce. In this retrospective analysis, we studied the outcome of 12 IBD kidney recipients (7 Crohn's disease, 5 ulcerative colitis; primary kidney disease was IgA nephropathy in 5, polycystic disease in 4), compared to two control groups: matched-controls, and a cohort of recipients with similar kidney disease. During a follow-up period of 60. Read More

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http://dx.doi.org/10.1111/tri.13415DOI Listing
February 2019

Comparing Web-Based Video Interventions to Enhance University Student Willingness to Donate Organs: A Randomized Controlled Trial.

Clin Transplant 2019 Feb 21:e13506. Epub 2019 Feb 21.

Center for Reducing Health Disparities, MetroHealth Campus of Case Western Reserve University, Cleveland, Ohio.

Background: The efficacy of video interventions to increase organ donation willingness remains unclear.

Methods: 3-arm web-based randomized controlled trial involving 2261 students at 3 northeastern Ohio universities. Intervention students watched a live-action (n=755) or animated (n=753) donation video. Read More

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http://dx.doi.org/10.1111/ctr.13506DOI Listing
February 2019

Multimodal Elimination for Intoxication with a Lethal Dose of Organic Mercury.

Case Rep Crit Care 2019 16;2019:4275918. Epub 2019 Jan 16.

Department of Cardiology and Angiology, Hannover Medical School, Germany.

We here report on a case of massive organic mercury intoxication in a 40-year-old man that resulted in progressive multiorgan failure. We treated the patient intravenously and enterally with the chelating agent (RS)-2,3-bis(sulfanyl) propane-1-sulfonic acid (DMPS) in addition to hemodialysis. The patient was treated for 6 weeks and could successfully be weaned from mechanical ventilation and hemodialysis. Read More

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http://dx.doi.org/10.1155/2019/4275918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354150PMC
January 2019

Health Professional-Identified Barriers to Living Donor Kidney Transplantation: A Qualitative Study.

Can J Kidney Health Dis 2019 13;6:2054358119828389. Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

Background: Living donor kidney transplantation (LDKT) has several advantages over deceased donor kidney transplantation. Yet rates of living donation are declining in Canada and there exists significant interprovincial variability. Efforts to improve living donation tend to focus on the patient and barriers identified at their level, such as not knowing how to ask for a kidney or lack of education. Read More

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http://dx.doi.org/10.1177/2054358119828389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376531PMC
February 2019

Central Blood Pressure and Pulse Wave Velocity Changes Post Renal Denervation in Patients With Stages 3 and 4 Chronic Kidney Disease: The Regina RDN Study.

Can J Kidney Health Dis 2019 13;6:2054358119828388. Epub 2019 Feb 13.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.

Background: Central aortic blood pressures and arterial stiffness are better indicators of cardiovascular outcomes than brachial blood pressures. However, their response to renal denervation (RDN) in patients with Stage 3 and Stage 4 chronic kidney disease (CKD) has not yet been examined.

Objective: To evaluate the impact of RDN on central blood pressures (CBP), brachial (office and ambulatory) blood pressures, arterial stiffness, glomerular filtration rate (GFR), 24-hour urine protein, and selective cardiac parameters observed on echocardiograms. Read More

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http://dx.doi.org/10.1177/2054358119828388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376516PMC
February 2019

A Validation Study of Administrative Health Care Data to Detect Acute Kidney Injury in the Pediatric Intensive Care Unit.

Can J Kidney Health Dis 2019 10;6:2054358119827525. Epub 2019 Feb 10.

Department of Pediatrics, Division of Nephrology, Toronto Hospital for Sick Children, University of Toronto, ON, Canada.

Background: Large studies evaluating pediatric acute kidney injury (AKI) epidemiology and outcomes are lacking, partially due to underuse of large administrative health care data.

Objective: To assess the diagnostic accuracy of administrative health care data-defined AKI in children admitted to the pediatric intensive care unit (PICU).

Design: Retrospective cohort study utilizing chart and administrative data. Read More

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http://dx.doi.org/10.1177/2054358119827525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376545PMC
February 2019

Significance of Earlier Initiation of Chemotherapy for Lung Cancer Complicated with Primary or Secondary Nephrotic Syndrome following Its Appropriate Differential Diagnosis.

Case Rep Oncol 2019 Jan-Apr;12(1):53-58. Epub 2019 Jan 11.

Division of Medical Oncology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

We encountered a case of primary lung cancer complicated with membranous nephropathy as primary nephrotic syndrome. Because treatment approaches vary greatly for primary and secondary nephrotic syndrome, a renal biopsy was performed for diagnosis. Much time was required to make a definitive diagnosis of primary nephrotic syndrome, as opposed to paraneoplastic nephrotic syndrome. Read More

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http://dx.doi.org/10.1159/000493851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381920PMC
January 2019

Treatment of Chemotherapy-Induced Thrombotic Microangiopathy with Eculizumab in a Patient with Metastatic Breast Cancer.

Case Rep Oncol 2019 Jan-Apr;12(1):1-6. Epub 2019 Jan 3.

Dialysis Center Ludwigsburg, Ludwigsburg, Germany.

The unexpected occurrence of thrombotic microangiopathy (TMA), characterised by microangiopathic haemolytic anaemia and thrombocytopenia, in a patient with cancer requires urgent diagnosis and appropriate management. TMA in patients with metastatic cancer can be a manifestation of the malignancy itself or a therapeutic complication. Distinguishing the cause of TMA is complicated but clinically important to initiate appropriate treatment of metastatic cancer and avoid potential drug toxicity. Read More

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http://dx.doi.org/10.1159/000495031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381888PMC
January 2019

Treatment of Renal Artery Stenosis in a Solitary Kidney Using Cutting Balloon Angioplasty in a Paediatric Patient.

Clin Med Insights Case Rep 2019 7;12:1179547619828721. Epub 2019 Feb 7.

Department of Interventional Radiology, Queen's Medical Centre (QMC), Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aims: Renovascular hypertension is a rare cause of paediatric hypertension. It is however, a potentially treatable cause particularly when caused by renal artery stenosis (RAS).

Materials And Methods: We present the case of an 11-month-old girl presenting with cardiac dysfunction. Read More

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http://dx.doi.org/10.1177/1179547619828721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376492PMC
February 2019

The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system.

Sci Rep 2019 Feb 21;9(1):2475. Epub 2019 Feb 21.

Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

The Drosophila Ncc69 gene encodes a Na-K-2Cl-cotransporter (NKCC) that is critical for regulating intra- and extracellular ionic conditions in different tissues. Here, we show that the Ncc69 transporter is necessary for fly vision and that its expression is required non-autonomously in glia to maintain visual synaptic transmission. Flies mutant for Ncc69 exhibit normal photoreceptor depolarization in response to a light pulse but lack the ON and OFF-transients characteristic of postsynaptic responses of lamina neurons, indicating a failure in synaptic transmission. Read More

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http://dx.doi.org/10.1038/s41598-019-38850-xDOI Listing
February 2019

Pre-eclampsia: pathogenesis, novel diagnostics and therapies.

Nat Rev Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Departments of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal and fetal morbidity and mortality. The disease presents with new-onset hypertension and often proteinuria in the mother, which can progress to multi-organ dysfunction, including hepatic, renal and cerebral disease, if the fetus and placenta are not delivered. Maternal endothelial dysfunction due to circulating factors of fetal origin from the placenta is a hallmark of pre-eclampsia. Read More

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http://dx.doi.org/10.1038/s41581-019-0119-6DOI Listing
February 2019

PIVOTAL trial: iron loading improves clinical outcomes.

Authors:
Daniel W Coyne

Nat Rev Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Washington University School of Medicine, Division of Nephrology, St Louis, MO, USA.

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http://dx.doi.org/10.1038/s41581-019-0128-5DOI Listing
February 2019

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01.

Nat Commun 2019 Feb 21;10(1):893. Epub 2019 Feb 21.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2. Read More

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http://dx.doi.org/10.1038/s41467-019-08790-1DOI Listing
February 2019

Role for nuclear interleukin-37 in the suppression of innate immunity.

Proc Natl Acad Sci U S A 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, University of Colorado Denver, Aurora, CO 80045;

The IL-1 family member IL-37 broadly suppresses innate inflammation and acquired immunity. Similar to IL-1α and IL-33, IL-37 is a dual-function cytokine in that IL-37 translocates to the nucleus but also transmits a signal via surface membrane receptors. The role of nuclear IL-37 remains unknown on the ability of this cytokine to inhibit innate inflammation. Read More

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http://dx.doi.org/10.1073/pnas.1821111116DOI Listing
February 2019

How to prescribe loop diuretics in oedema.

BMJ 2019 Feb 21;364:l359. Epub 2019 Feb 21.

The Dartmouth Institute for Health Policy & Clinical Practice, The Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1136/bmj.l359DOI Listing
February 2019

C-reactive protein as a prognostic risk factor for loss of arteriovenous fistula patency in hemodialyzed patients.

J Vasc Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Hemodialysis, Arad Municipal Clinical Emergency Hospital, Arad, Romania; Department of Internal Medicine, Faculty of Medicine, "Vasile Goldis" Western University of Arad, Arad, Romania; B. Braun Avitum Dialysis Center Arad, Arad, Romania.

Background: Inflammation is a cardiovascular risk factor in hemodialysis patients, but its influence on vascular access patency is still debatable. Our prospective study investigated this issue.

Methods: A total of 258 patients receiving an arteriovenous fistula (AVF) between 2006 and 2016 at the Municipal Hospital Arad were included. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.100DOI Listing
February 2019

Comparing clinical judgment with the MySurgeryRisk algorithm for preoperative risk assessment: A pilot usability study.

Surgery 2019 Feb 18. Epub 2019 Feb 18.

Precision and Intelligent Systems in Medicine (PRISMA(P)), Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville; Department of Medicine, University of Florida College of Medicine, Gainesville. Electronic address:

Background: Major postoperative complications are associated with increased cost and mortality. The complexity of electronic health records overwhelms physicians' abilities to use the information for optimal and timely preoperative risk assessment. We hypothesized that data-driven, predictive-risk algorithms implemented in an intelligent decision-support platform simplify and augment physicians' risk assessments. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.002DOI Listing
February 2019

Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.

Kidney Int 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Ectopic fat deposition (EFD) in the kidney has been shown to play a causal role in diabetic nephropathy; however, the mechanism underlying EFD remains elusive. By transcriptome analysis, we found decreased expression levels of disulfide-bond A oxidoreductase-like protein (DsbA-L) in the kidneys of diabetic mice (induced by high-fat diet plus Streptozotocin) compared with control mice. Increased expression of adipocyte differentiation-related protein and abnormal levels of collagen I, fibronectin, and phosphorylated 5'AMP-activated kinase (p-AMPK), adipose triglyceride lipase (p-ATGL), and HMG-CoA reductase (p-HMGCR) were also observed in diabetic mice. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.038DOI Listing
February 2019

Not only Alagille syndrome. Syndromic paucity of interlobular bile ducts secondary to HNF1β deficiency: a case report and literature review.

Ital J Pediatr 2019 Feb 21;45(1):27. Epub 2019 Feb 21.

Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza, University of Turin, Piazza Polonia 94, 10126, Turin, Italy.

Background: paucity of interlobular bile ducts is an important observation at liver biopsy in the diagnostic work-up of neonatal cholestasis. To date, other than in the Alagille syndrome, syndromic paucity of interlobular bile ducts has been documented in four cholestatic neonates with HFN1β mutations. A syndromic phenotype, known as renal cysts and diabetes syndrome (RCAD), has been identified. Read More

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http://dx.doi.org/10.1186/s13052-019-0617-yDOI Listing
February 2019

Unilateral renal artery stenosis presented with hyponatremic-hypertensive syndrome - case report and literature review.

BMC Nephrol 2019 Feb 21;20(1):64. Epub 2019 Feb 21.

Division of Nephrology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, No 5, Fu-Shing ST., Kwei-Shan, 33305, Taoyuan, Taiwan.

Background: Renal artery stenosis is one of the secondary causes of pediatric hypertension. Cases with critical unilateral renal artery stenosis manifesting with the hyponatremic hypertensive syndrome are rare and a comprehensive description of this disorder in the pediatric population is lacking in the literature.

Case Presentation: We describe a 4-year-old boy who presented with severe hypertension, profound hyponatremia, hypokalemia, nephrotic range proteinuria, and polyuria. Read More

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http://dx.doi.org/10.1186/s12882-019-1246-9DOI Listing
February 2019

Serum klotho: a potential predictor of cerebrovascular disease in hemodialysis patients.

BMC Nephrol 2019 Feb 21;20(1):63. Epub 2019 Feb 21.

Department of Nephrology, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430033, People's Republic of China.

Background: Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk factors of cerebrovascular disease. The purpose of the present study is to determine the relationship between serum klotho and cerebrovascular disease in patients receiving hemodialysis. Read More

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http://dx.doi.org/10.1186/s12882-019-1232-2DOI Listing
February 2019

Safety and tolerability of sifalimumab, an anti-interferon-α monoclonal antibody, in Japanese patients with systemic lupus erythematosus: a multicentre, phase 2, open-label study.

Mod Rheumatol 2019 Feb 21:1-19. Epub 2019 Feb 21.

i AstraZeneca , USA.

Objectives: To evaluate the safety of sifalimumab in Japanese patients with systemic lupus erythematosus (SLE).

Methods: This phase 2, open-label study consisted of a 52-week initial stage (Stage I) and a long-term extension (Stage II). In Stage I, sequential cohorts of patients received ascending doses of sifalimumab (intravenous [IV] 1. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583832DOI Listing
February 2019

FGF23 and Fetuin-A Interaction and Mesenchymal Osteogenic Transformation.

Int J Mol Sci 2019 Feb 20;20(4). Epub 2019 Feb 20.

Renal Research Laboratory Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Recently, we found a strict bone association between Fibroblast growth factor 23 (FGF23) and Fetuin-A, both involved in cardiovascular and mineral bone disorders. In this study, an uninvestigated bone marrow positivity for both was found. Though the role of exogenous FGF23 on mesenchymal cells (MSCs) was reported, no information is as yet available on the possible production of this hormone by MSCs. Read More

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http://dx.doi.org/10.3390/ijms20040915DOI Listing
February 2019

Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Division of Nephrology, RWTH Aachen University, 52074 Aachen, Germany.

Vitamin K is an essential bioactive compound required for optimal body function. Vitamin K can be present in various isoforms, distinguishable by two main structures, namely, phylloquinone (K1) and menaquinones (K2). The difference in structure between K1 and K2 is seen in different absorption rates, tissue distribution, and bioavailability. Read More

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http://dx.doi.org/10.3390/ijms20040896DOI Listing
February 2019

Pim-1 as a therapeutic target in human lupus nephritis.

Arthritis Rheumatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Rheumatology and Immunology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

Objective: Lupus nephritis (LN) is a major determinant of morbidity and mortality in systemic lupus erythematosus (SLE). Pim-1 regulates lymphocyte proliferation and activation. The role of Pim-1 in autoimmune disease remains unclear. Read More

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http://dx.doi.org/10.1002/art.40863DOI Listing
February 2019

Early use of PEPA dialyzer for light chains removal and for the recovery from myeloma cast nephropathy: A case report.

Hemodial Int 2019 Feb 21. Epub 2019 Feb 21.

Nephrology Dialysis and Renal Transplantation Unit, L. & A. Seràgnoli, S.Orsola University Hospital, Bologna, Italy.

Chemotherapy and extracorporeal treatment reduce serum free light chains (FLCs) allowing the recovery of acute kidney injury (AKI) caused by myeloma cast nephropathy (MCN). We report the first case of recovery from AKI in a patient with MCN who underwent the removal of FLCs using the PEPA filter, with an undisclosed cut-off, combined with chemotherapy for multiple myeloma (MM). Read More

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http://dx.doi.org/10.1111/hdi.12733DOI Listing
February 2019

Eleven novel SLC12A1 variants and an exonic mutation cause exon skipping in Bartter syndrome type I.

Endocrine 2019 Feb 21. Epub 2019 Feb 21.

Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, No.5 Donghai Middle Road, 266071, Qingdao, People's Republic of China.

Introduction: Bartter syndrome type I (BS1) has been rarely reported in large groups. On the other hand, the phenomenon of exon skipping, in which exonic mutations result in abnormal splicing, has been reported to be associated with various diseases. Specifically, mutations that result in the disruption of exonic splicing enhancers (ESEs) and/or the creation of exonic splicing silencers (ESSs) can promote exon skipping. Read More

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http://dx.doi.org/10.1007/s12020-019-01856-6DOI Listing
February 2019

A child with bilateral multiple renal cysts presenting with ascites and pleural effusion: Answers.

Pediatr Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Haseki Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-4198-1DOI Listing
February 2019

A child with bilateral multiple renal cysts presenting with ascites and pleural effusion: Questions.

Pediatr Nephrol 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Haseki Education and Research Hospital, University of Health Sciences, Istanbul, Turkey.

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http://dx.doi.org/10.1007/s00467-019-4196-3DOI Listing
February 2019

Recent evidence for direct oral anticoagulants in chronic kidney disease.

Curr Opin Nephrol Hypertens 2019 Feb 14. Epub 2019 Feb 14.

The George Institute for Global Health, UNSW Sydney.

Purpose Of Review: The direct oral anticoagulants (DOACs) have emerged as an effective and safe alternative to vitamin K antagonists (VKAs) for stroke and venous thromboembolism (VTE) prevention. However, patients with chronic kidney disease (CKD) experience an increase in the risk of both thromboembolism and bleeding, and the risk-benefit profile of DOACs, particularly in advanced CKD remains a source of ongoing debate. This review summarizes the recent evidence on the effects of DOACs in CKD across a range of clinical indications including newly emerging indications. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000493DOI Listing
February 2019