131,630 results match your criteria Nephrology Carlton Vic.[Journal]


Routine Is the Worst Enemy of the Dialysis Patient.

Blood Purif 2019 Apr 18:1-2. Epub 2019 Apr 18.

Clinical Research Branch, Division of Nephrology, Miulli General Hospital, Acquaviva delle Fonti, Italy.

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http://dx.doi.org/10.1159/000498980DOI Listing

Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing

Chronic Kidney Disease in Agricultural Communities.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Informatics, The Ohio State University. Electronic address:

Patients residing in agricultural communities have a high risk of developing chronic kidney disease. In the Great Plains, geo-environmental risk factors (variable climate, temperature, air quality, water quality and drought) combine with agro-environmental risk factors (exposure to fertilizers, soil conditioners, herbicides, fungicides and pesticides) to increase risk for toxic nephropathy. However, research defining the specific influence of agricultural chemicals on the progression of kidney disease in rural communities has been somewhat limited. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.03.036DOI Listing

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice.

PLoS One 2019 18;14(4):e0211559. Epub 2019 Apr 18.

Kidney Disease Section, NIDDK, NIH, Bethesda, Maryland, United States of America.

Apolipoprotein L1 (APOL1) genetic variants G1 and G2, compared to the common allele G0, are major risk factors for non-diabetic kidney disease in African descent populations. APOL1 is a minor protein component of HDL, as well as being expressed in podocytes and vascular cells. Reverse cholesterol transport involves the transport of cholesterol to HDL by cellular ATP-binding cassette; ABCA1 and ABCG1 with subsequent delivery from peripheral tissues to the liver. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211559PLOS

Antipsychotics in the general population and the driver population: comparisons from a population-based registry study.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Valladolid.

Antipsychotics are considered driving-impairing medicines. A population-based registry study design was conceived to assess the year-2016 antipsychotic dispensation in Castile and León, Spain. Weighting was performed to obtain the adjusted antipsychotic consumption for licensed drivers according to age and gender using the Spanish national drivers' license census data. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000263DOI Listing

Annexin A3 depletion overcomes resistance to oxaliplatin in colorectal cancer via the MAPK signaling pathway.

J Cell Biochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

Colorectal cancer (CRC) is a common disease with high mortality and morbidity. Annexin A3 (ANXA3) belongs to the structurally homologous family of Ca and phospholipid-binding proteins. This study aimed to investigate the effects and potential mechanisms of ANXA3 on oxaliplatin (Ox) resistance in CRC. Read More

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http://dx.doi.org/10.1002/jcb.28720DOI Listing

Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

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http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

Assessing the nephrotoxicity of intravenous iodinated contrast agents in patients with chronic renal failure in the absence of interfering acute disease.

Acta Radiol 2019 Apr 18:284185119840764. Epub 2019 Apr 18.

1 Department of Radiology, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Sabadell, Spain.

Background: The existence of contrast-induced nephropathy is widely accepted. Recent studies suggest its incidence has been overestimated.

Purpose: To determine the effect of intravenous iodinated contrast agents on renal function in patients with chronic renal failure without acute disease that can interfere with the assessment of renal function. Read More

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http://dx.doi.org/10.1177/0284185119840764DOI Listing

NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway.

Arch Dermatol Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Previous studies have identified neuron navigator 2(NAV2) as an oncogene in several human tumors. However, the NAV2 gene expression changes and its role in the pathogenesis of cutaneous melanoma have not been clearly illustrated. Further investigations of NAV2 in cutaneous melanoma may provide new mechanistic insight and treatment strategy for this disease. Read More

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http://dx.doi.org/10.1007/s00403-019-01909-wDOI Listing

Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.

Kidney Int Rep 2019 Apr 21;4(4):541-550. Epub 2018 Dec 21.

Department of Pediatrics, Division of Pediatric Nephrology, Duke University, Durham, North Carolina, USA.

Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients.

Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months posttransplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-α, interferon [IFN]-γ, interleukin [IL]-8, IL-1β, IL-6, and IL-17). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183035
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http://dx.doi.org/10.1016/j.ekir.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451195PMC
April 2019
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Reducing red blood cell folate testing: a case study in utilisation management.

BMJ Open Qual 2019 7;8(1):e000531. Epub 2019 Mar 7.

Pathology and Laboratory Medicine, Western University, London, Ontario, Canada.

Mandatory enrichment of wheat flour in Canada with folic acid since 1998 has caused folate deficiency to be rare. There were 3019 red blood cell (RBC) folate tests performed during an 18-month period at London Health Sciences Centre (LHSC)/St. Joseph's Healthcare London (SJHC) without any folate deficiency detected. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440601PMC

Reporting quality of pilot clinical trials in chronic kidney disease patients on hemodialysis: a methodological survey.

Pilot Feasibility Stud 2019 6;5:53. Epub 2019 Apr 6.

3Department of Health Research, Evidence, and Impact, McMaster University, Hamilton, Ontario Canada.

Background: The conduct of high-quality pilot studies can help inform the success of larger clinical trials. Guidelines have been recently developed for the reporting of pilot trials.

Objective: This methodological survey evaluates the completeness of reporting in pilot randomized controlled trials in chronic kidney disease patients on hemodialysis (HD patients) and explores factors associated with better completion of reporting. Read More

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http://dx.doi.org/10.1186/s40814-019-0436-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451784PMC

Prevalence of early stages of heart failure in an elderly risk population: the Copenhagen Heart Failure Risk Study.

Open Heart 2019 27;6(1):e000840. Epub 2019 Feb 27.

Department of Cardiology, Herlev and Gentofte University Hospital, Herlev, Denmark.

Aims: To describe the prevalence of heart failure (HF) stages in elderly outpatients with risk factors for HF but without known HF, and characterise the clinical, biochemical and echocardiographic findings in each stage.

Background: Early stages of HF are underdiagnosed; nevertheless, they are associated with an increased risk of hospitalisation and increased mortality. The prevalence of HF stages in elderly high-risk patients is unknown. Read More

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http://dx.doi.org/10.1136/openhrt-2018-000840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443139PMC
February 2019

Postbiopsy arteriovenous fistula in renal allograft: An ultrasound case study.

Clin Case Rep 2019 Apr 17;7(4):834-835. Epub 2019 Feb 17.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Arteriovenous fistula is a well-known but rarely diagnosed complication of percutaneous renal biopsy. On Doppler sonography, these fistulae are characterized by a region of high velocity shifts and random color assignment due to vibrating interfaces in the perivascular tissue. Most of them resolve spontaneously, while larger symptomatic ones need intervention. Read More

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http://dx.doi.org/10.1002/ccr3.2059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452476PMC

Peritonitis from : An emerging pathogen.

Clin Case Rep 2019 Apr 18;7(4):829-831. Epub 2019 Mar 18.

Department of Family Medicine Kaweah Delta Medical Center Visalia California.

can be misidentified as , due to similar biochemical properties. Automated identification systems and mass spectrometry play a very critical role in isolating atypical organisms like . General guidelines recommend treating peritonitis for 3 weeks without removal of peritoneal dialysis catheter. Read More

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http://dx.doi.org/10.1002/ccr3.2094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452466PMC

An adult case of atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) similar to adult-onset Still's disease.

Clin Case Rep 2019 Apr 12;7(4):801-805. Epub 2019 Mar 12.

Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan.

We present a 55-year-old woman with periodic fever and symptoms similar to adult-onset Still's disease (AOSD). She had a heterogeneous mutation of the gene and colchicine was effective. Atypical familial Mediterranean fever (pyrin-associated autoinflammatory disease) should be considered in patients with periodic fever accompanied by symptoms similar to AOSD. Read More

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http://dx.doi.org/10.1002/ccr3.2102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452483PMC

Refractory exudative pleural effusion in patients with chronic kidney disease not receiving dialysis: A case report.

Clin Case Rep 2019 Apr 19;7(4):675-679. Epub 2019 Feb 19.

Division of Nephrology, Department of Internal Medicine, School of Medicine, Jeju National University Hospital Jeju National University Jeju City Korea.

Although exudative pleural effusion can be caused by infections, malignancies, and connective tissue diseases, we need to consider uremic pleural effusion and pleuritis in differential diagnosis of exudative lymphocyte predominant pleural effusion in patients with chronic kidney disease not receiving dialysis. Read More

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http://dx.doi.org/10.1002/ccr3.2069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452446PMC

The frequency of Epstein-Barr virus among hemodialysis patients, Ahvaz, Iran.

Iran J Microbiol 2019 Feb;11(1):75-79

School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background And Objectives: Epstein-Barr virus (EBV) has infected more than 90% of adults worldwide. EBV infection is asymptomatic in healthy individuals and is controlled by a robust immune response while in individuals with weakened immunesystems including Hemodialysis (HD) patients and transplant recipients leads to serious illnesses. This study was aimed to investigate the frequency of EBV among the HD patients. Read More

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February 2019

Low serum C3 level, high neutrophil-lymphocyte-ratio, and high platelet-lymphocyte-ratio all predicted poor long-term renal survivals in biopsy-confirmed idiopathic membranous nephropathy.

Sci Rep 2019 Apr 17;9(1):6209. Epub 2019 Apr 17.

Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Idiopathic membranous nephropathy (iMN) is the major cause of end-stage renal disease (ESRD). Recent guidelines suggest limiting immunosuppressants only to high risk patients for ESRD. The present study is aimed at identifying new predictors for the renal outcome of iMN patients. Read More

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http://dx.doi.org/10.1038/s41598-019-42689-7DOI Listing

IgG4-related Periarteritis Successfully Diagnosed by an Alternative Prostate Biopsy: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Japan.

A 56-year-old man was referred to our facility after developing edema in his right leg. Enhanced computed tomography (CT) revealed a periarterial soft tissue mass surrounding the right iliac artery compressing the iliac vein. His elevated serum IgG4 level indicated IgG4-related disease (IgG4-RD). Read More

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http://dx.doi.org/10.2169/internalmedicine.2723-19DOI Listing

Proton-pump Inhibitor-induced Severe Hypomagnesemia and Hypocalcemia are Clinically Masked by Thiazide Diuretic.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Japan.

Hypomagnesemia, a side effect of proton-pump inhibitors (PPIs), can be asymptomatic. The presence of hypocalcemia or hypokalemia is indicative of hypomagnesemia; however, the concomitant use of PPIs and thiazide may mask hypocalcemia. A 79-year-old woman with a history of chronic heart failure and chronic kidney disease developed symptomatic hypocalcemia and hypomagnesemia. Read More

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http://dx.doi.org/10.2169/internalmedicine.2608-18DOI Listing

A 29-year-old Woman with Recurrent Pregnancy-induced Hypertension Based on Vascular Compression of the Medulla Oblongata.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Education and Support for Regional Medicine, Tohoku University Hospital, Japan.

We present a report of a 29-year-old woman with non-dipper type refractory hypertension due to the vascular compression of the medulla oblongata. The patient was diagnosed with hypertension at 17 years of age and underwent emergency Caesarean section at 26 weeks of gestation during 2 pregnancies due to severe high blood pressure. We suspected medullary compression by the curved posterior inferior cerebellar artery as the cause of her intractable hypertension, and she underwent Jannetta's decompression surgery. Read More

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http://dx.doi.org/10.2169/internalmedicine.2382-18DOI Listing

Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Biased agonism is a paradigm that may explain the selective activation of a signaling pathway via a GPCR that activates multiple signals. The autoantibody-induced inactivation of the calcium-sensing receptor (CaSR) causes acquired hypocalciuric hypercalcemia (AHH). Here, we describe an instructive case of AHH in which severe hypercalcemia was accompanied by an increased CaSR antibody titer. Read More

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http://dx.doi.org/10.1172/jci.insight.126449DOI Listing

The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Dermatology.

Autoimmune disease is 4 times more common in women than men. This bias is largely unexplained. Female skin is "autoimmunity prone," showing upregulation of many proinflammatory genes, even in healthy women. Read More

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http://dx.doi.org/10.1172/jci.insight.127291DOI Listing

Hypoglycemia in People with Type 2 Diabetes and CKD.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Kidney Research Institute.

Background And Objectives: Among people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.

Design, Setting, Participants & Measurements: We enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1. Read More

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http://dx.doi.org/10.2215/CJN.11650918DOI Listing

Hepatorenal Syndrome.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatorenal syndrome is a severe complication of end-stage cirrhosis characterized by increased splanchnic blood flow, hyperdynamic state, a state of decreased central volume, activation of vasoconstrictor systems, and extreme kidney vasoconstriction leading to decreased GFR. The contribution of systemic inflammation, a key feature of cirrhosis, in the development of hepatorenal syndrome has been highlighted in recent years. The mechanisms by which systemic inflammation precipitates kidney circulatory changes during hepatorenal syndrome need to be clarified. Read More

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http://dx.doi.org/10.2215/CJN.12451018DOI Listing

Disseminated subcutaneous nodules and destructive polyarthritis.

BMJ 2019 Apr 17;365:l1344. Epub 2019 Apr 17.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1136/bmj.l1344DOI Listing

A turning point for chronic kidney disease in diabetes.

Lancet 2019 Apr 12. Epub 2019 Apr 12.

Providence Medical Research Center, Providence Health Care, Spokane, WA 99204, USA; Nephrology Division, Kidney Research Institute and Institute of Translational Health Sciences, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)30855-4DOI Listing

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial.

Lancet 2019 Apr 12. Epub 2019 Apr 12.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.

Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. Read More

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http://dx.doi.org/10.1016/S0140-6736(19)30772-XDOI Listing

Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury.

Stem Cell Res Ther 2019 Apr 17;10(1):119. Epub 2019 Apr 17.

Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells is based on their paracrine/endocrine activity, including release of bioactive factors that act on injured renal cells and presentation of proangiogenic, antiapoptotic, antioxidative, and immunomodulatory effects. Recently, multiple studies have confirmed that extracellular vesicles (EVs) are a kind of vesicle rich in a broad variety of biologically active molecules, including lipids, proteins, and, in particular, nucleic acids. Read More

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http://dx.doi.org/10.1186/s13287-019-1227-8DOI Listing

Modulating autophagy in mesenchymal stem cells effectively protects against hypoxia- or ischemia-induced injury.

Stem Cell Res Ther 2019 Apr 17;10(1):120. Epub 2019 Apr 17.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerates cellular building blocks; thus, autophagy maintains cellular and tissue homeostasis in all eukaryotic cells. In general, adaptive autophagy increases when cells confront stressful conditions to improve the survival rate of the cells, while destructive autophagy is activated when the cellular stress is not manageable and elicits the regenerative capacity. Hypoxia-reoxygenation (H/R) injury and ischemia-reperfusion (I/R) injury initiate excessive autophagy and endoplasmic reticulum (ER) stress and consequently induce a string of damage in mammalian tissues or organs. Read More

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http://dx.doi.org/10.1186/s13287-019-1225-xDOI Listing

Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells.

Cell Commun Signal 2019 Apr 17;17(1):37. Epub 2019 Apr 17.

Division of Nephrology, Department of Medicine, McMaster University, Hamilton, Canada.

Background: We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is involved in regulating matrix production, we had identified significant upregulation of the antifibrotic protein follistatin in cav-1 knockout MC. Follistatin inhibits the profibrotic effects of several members of the transforming growth factor beta superfamily, in particular the activins. Read More

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http://dx.doi.org/10.1186/s12964-019-0351-5DOI Listing

Uncoupling Protein 2 Increases Blood Pressure in DJ -1 Knockout Mice.

J Am Heart Assoc 2019 May;8(9):e011856

3 Research Center for Genetic Medicine Children's National Health System Washington DC.

Background The redox-sensitive chaperone DJ -1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal-selective depletion and germline deletion of DJ -1 increases blood pressure in mice. This study aimed to determine the mechanisms involved in the oxidative stress-mediated hypertension in DJ -1 mice. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.011856
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http://dx.doi.org/10.1161/JAHA.118.011856DOI Listing
May 2019
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MicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease.

FASEB J 2019 Apr 17:fj201900363R. Epub 2019 Apr 17.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms due to the selective loss of midbrain dopaminergic neurons. The evidence for a chronic inflammatory reaction mediated by microglial cells in the brain is particularly strong in PD. In our previous study, we have shown that brain-specific microRNA-124 (miR-124) is significantly down-regulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD and that it can also inhibit neuroinflammation during the development of PD. Read More

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http://dx.doi.org/10.1096/fj.201900363RDOI Listing

The Effects of Short-Term Immunosuppressive Therapy on Redox Parameters in the Livers of Pregnant Wistar Rats.

Int J Environ Res Public Health 2019 Apr 16;16(8). Epub 2019 Apr 16.

Department of Histology and Embryology, Pomeranian Medical University in Szczecin, Powst. Wlkp. 72, 70-111 Szczecin, Poland.

Immunosuppressive drugs are widely used to avoid graft rejection, but they are also known to be strongly hepatotoxic. The goal of the current study was to determine: (i) the immunoexpression of SOD1, CAT, GPX1; (ii) the concentration of MDA, GSH; (iii) the activity of SOD, CAT, GPX, in the native liver of a pregnant female rats undergoing immunosuppressive therapy. The study was based on archival material obtained from Department of Nephrology, Transplantology and Internal Medicine of the Independent Public Clinical Hospital No. Read More

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http://dx.doi.org/10.3390/ijerph16081370DOI Listing

Intensive care unit management: Renal replacement therapy, ventilator management, volume assessment, and optimal management of hypotension.

Clin Liver Dis (Hoboken) 2017 Mar 30;9(3):69-72. Epub 2017 Mar 30.

Departments of Internal Medicine and Surgery, Hepatology and Critical Care Medicine University of Kansas Medical Center Kansas City KS.

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http://dx.doi.org/10.1002/cld.621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467146PMC

Treating hepatitis C viral infection in patients with chronic kidney disease: When and how.

Clin Liver Dis (Hoboken) 2017 Mar 30;9(3):55-59. Epub 2017 Mar 30.

University of Miami Miller School of Medicine Division of Nephrology and Hypertension and the Miami Veterans Administration Hospital Miami FL.

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http://doi.wiley.com/10.1002/cld.617
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http://dx.doi.org/10.1002/cld.617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467141PMC
March 2017
1 Read

Diagnostic approach to renal failure in cirrhosis.

Clin Liver Dis (Hoboken) 2013 Jun 21;2(3):128-131. Epub 2013 Jun 21.

Gastrointestinal Units, Institute of Digestive and Metabolic Diseases, Hospital Clinic, University of Barcelona, Barcelona, Spain.

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http://doi.wiley.com/10.1002/cld.202
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http://dx.doi.org/10.1002/cld.202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448636PMC
June 2013
1 Read

Renal failure and liver transplantation.

Clin Liver Dis (Hoboken) 2013 Jun 21;2(3):106-108. Epub 2013 Jun 21.

Nephrology Division, University of Arizona, Tucson, AZ 85724.

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http://dx.doi.org/10.1002/cld.170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448629PMC

Acute Allograft Renal Vein Thrombosis: A Case Report.

Oman Med J 2014 Sep;29(5):e079

Nephrology Unit, Department of Medicine, Sultan Qaboos University Hospital, PO Box. 35, PC 123 Al-Khodh, Muscat, Sultante of Oman.

Renal graft thrombosis is a serious and devastating complication of renal transplant that ultimately results in graft loss. It is associated with acute and hyper-acute rejections; however, the underlying cause in large proportion of patients remains unknown. We report a case of a young male who underwent live related kidney transplant but lost the graft on the operating table due to renal vein thrombosis (RVT). Read More

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http://dx.doi.org/10.5001/omj.2014.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451753PMC
September 2014

Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing

Corrigendum.

Authors:

Nephrology (Carlton) 2019 May;24(5):586

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http://dx.doi.org/10.1111/nep.13590DOI Listing

Kidney Disease Awareness and Knowledge among Survivors ofAcute Kidney Injury.

Am J Nephrol 2019 Apr 17;49(6):449-459. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Vanderbilt Center for Kidney Diseases (VCKD) and Integrated Program for AKI Research (VIP-AKI), Nashville, Tennessee, USA.

Background: Acute kidney injury (AKI) survivors are at risk for chronic kidney disease, recurrent AKI, and cardiovascular disease. The transition from hospital to ambulatory care is an opportunity to reduce these sequelae by launching self-care plans through effective patient education. How well AKI survivors are informationally prepared to apply kidney-specific self-care is unknown. Read More

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https://www.karger.com/Article/FullText/499862
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http://dx.doi.org/10.1159/000499862DOI Listing
April 2019
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Key Updates in Cardio-Nephrology from 2018: Springboard to a Bright Future.

Cardiorenal Med 2019 Apr 17;9(4):222-228. Epub 2019 Apr 17.

Baylor University Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1159/000498916DOI Listing

Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.

Cell Rep 2019 Apr;27(3):699-707.e4

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) proteins work in concert to regulate the levels of reactive oxygen species (ROS). The Keap1-Nrf2 antioxidant system also participates in T cell differentiation and inflammation, but its role in innate T cell development and functions remains unclear. We report that T cell-specific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.052DOI Listing

Chronic kidney disease in patients infected with human immunodeficiency virus (HIV) in an urban cohort.

PLoS One 2019 17;14(4):e0215575. Epub 2019 Apr 17.

Nephrology Training Program at Houston Methodist Hospital, Houston, Texas, United States of America.

Background And Objectives: HIV-infected patients are at risk for developing chronic kidney disease (CKD), defined by estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m2. Our purpose was to understand the genesis of CKD in HIV patients from a large urban clinic in Houston, Texas, USA, and to characterize progression of CKD in the cohort. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215575PLOS

AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis and ameliorates ischemic AKI .

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Medicine / Nephroloy, University of Illinois, Chicago, United States.

We have reported that preconditioning renal tubular cells (RTCs) with A-769662 (a pharmacologic activator of AMPK) reduces apoptosis of RTCs induced by subsequent stress, and ameliorates the severity of ischemic AKI in mice. In this study we examined the role of the PI3K/Akt pathway in mediating these effects. To confirm that any observed novel effects of A-769662 are mediated specifically by AMPK, we developed knockdown ("KD") RTCs using shRNA. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00553.2018
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http://dx.doi.org/10.1152/ajprenal.00553.2018DOI Listing
April 2019
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Adenosine kinase inhibition protects against cisplatin-induced nephrotoxicity.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department Of Nephrology, The First Affiliated Hospital of Nanjing Medical University.

Numerous studies have demonstrated that several mechanisms, including oxidative stress, DNA damage and inflammatory responses, are closely linked to cisplatin-induced nephrotoxicity. Adenosine, emerging as a key regulatory molecule, is mostly protective in the pathophysiology of inflammatory diseases. Previous study showed that some of the adenosine receptors led to renal protection against ischemia-reperfusion injury. Read More

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https://www.physiology.org/doi/10.1152/ajprenal.00385.2018
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http://dx.doi.org/10.1152/ajprenal.00385.2018DOI Listing
April 2019
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