7,094 results match your criteria Nephrology [Journal]


Modelling diabetic vasculopathy with human vessel organoids.

Authors:
Ryuji Morizane

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Renal Division, Brigham and Women's Hospital, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0125-8DOI Listing
February 2019

Growing mouse kidneys in rats.

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Nephrology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0127-6DOI Listing
February 2019

Fluid flow enhances vascularization and maturation of kidney organoids.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Nephrology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0126-7DOI Listing
February 2019

Differences in association of lower bone mineral density with higher coronary calcification in female and male end-stage renal disease patients.

BMC Nephrol 2019 Feb 18;20(1):59. Epub 2019 Feb 18.

Division of Renal Medicine and Baxter Novum, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.

Background: Risk of cardiac events and cardiovascular disease (CVD) in end-stage renal disease (ESRD) patients are predicted by coronary artery calcification (CAC) independently. It is not clear to what extent low bone mineral density (BMD) is associated with higher risk of CAC and if sex interacts. We investigated the sex-specific associations of CAC score with total body BMD (tBMD) as well as with BMD of different skeletal sub-regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1235-zDOI Listing
February 2019

Intravenous pulse methylprednisolone for induction of remission in severe ANCA associated Vasculitis: a multi-center retrospective cohort study.

BMC Nephrol 2019 Feb 18;20(1):58. Epub 2019 Feb 18.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Background: Intravenous pulse methylprednisolone (MP) is commonly included in the management of severe ANCA associated vasculitis (AAV) despite limited evidence of benefit. We aimed to evaluate outcomes in patients who had, or had not received MP, along with standard therapy for remission induction in severe AAV.

Methods: We retrospectively studied 114 consecutive patients from five centres in Europe and the United States with a new diagnosis of severe AAV (creatinine > 500 μmol/L or dialysis dependency) and that received standard therapy (plasma exchange, cyclophosphamide and high-dose oral corticosteroids) for remission induction with or without pulse MP between 2000 and 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1226-0DOI Listing
February 2019

Cyclin G1 drives maladaptive renal repair.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Nephrology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0124-9DOI Listing
February 2019

Albuminuria: a target for clinical trials in kidney disease?

Nat Rev Nephrol 2019 Feb 14. Epub 2019 Feb 14.

Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0123-xDOI Listing
February 2019

Serum indoxyl sulfate is associated with mortality in hospital-acquired acute kidney injury: a prospective cohort study.

BMC Nephrol 2019 Feb 14;20(1):57. Epub 2019 Feb 14.

Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, 639 Zhizaoju Road, Shanghai, 200011, China.

Background: Protein-bound uremic toxins are associated with poor outcomes in patients with chronic kidney disease. The aim of this study is to investigate the relationship between indoxyl sulfate (IS), a protein-bound solute, and 90-day mortality in patients with acute kidney injury.

Methods: Adults with hospital-acquired AKI (HA-AKI) were enrolled in this prospective cohort study between 2014 and 2015, according to the KDIGO creatinine criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1238-9DOI Listing
February 2019
1 Read

Angiotensin II receptor blockade is associated with preserved muscle strength in chronic hemodialysis patients.

BMC Nephrol 2019 Feb 14;20(1):54. Epub 2019 Feb 14.

Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

Background: Sarcopenia, defined as low muscle mass and strength, is highly prevalent in patients undergoing chronic hemodialysis (HD). However, muscle function and muscle mass do not share the same clinical relevance. In fact, muscle strength was more closely associated with the risk of mortality in chronic HD patients than was muscle mass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1223-3DOI Listing
February 2019

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
February 2019
2 Reads

Identifying on admission patients likely to develop acute kidney injury in hospital.

BMC Nephrol 2019 Feb 14;20(1):56. Epub 2019 Feb 14.

Research, Development, and Innovation, Royal Cornwall Hospitals NHS Trust, Truro, TR1 3HD, UK.

Background: The incidence of Acute Kidney Injury (AKI) continues to increase in the UK, with associated mortality rates remaining significant. Approximately one fifth of hospital admissions are associated with AKI and approximately a third of patients with AKI in hospital develop AKI during their time in hospital. A fifth of these cases are considered avoidable. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1237-xDOI Listing
February 2019
3 Reads

Revisiting racial differences in ESRD due to ADPKD in the United States.

BMC Nephrol 2019 Feb 14;20(1):55. Epub 2019 Feb 14.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, 06520, USA.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) affects all races. Whether the progression of ADPKD varies by race remains unclear.

Methods: In this retrospective cohort study from 2004 to 2013 non-Hispanic blacks and non-Hispanic whites of all ages classified in the US Renal Data System (USRDS) with incident ESRD from ADPKD (n = 23,647), hypertension/large vessel disease (n = 296,352), or diabetes mellitus (n = 451,760) were stratified into five-year age categories ranging from < 40 to > 75 (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1241-1DOI Listing
February 2019

Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: a matched cohort study.

BMC Nephrol 2019 Feb 13;20(1):52. Epub 2019 Feb 13.

Department of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.

Background: The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemodialysis (IHD) and peritoneal dialysis (PD), taking age and comorbidity into account. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1245-xDOI Listing
February 2019

Correction to: The elevated levels of urinary angiotensinogen are correlated with the severity of idiopathic membranous nephropathy.

BMC Nephrol 2019 Feb 13;20(1):50. Epub 2019 Feb 13.

Department of Nephrology, Peking University Third Hospital, No. 49, North Garden Road, Haidian District, Beijing, 100191, China.

Following publication of the original article [1], it was reported that, due to a typesetting mistake, the three tables and two figures for this article were included as an Additional file instead of in the body of the article. The original publication of this article has been updated to correct this. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1229-xDOI Listing
February 2019

Post renal transplant anemia: severity, causes and their association with graft and patient survival.

BMC Nephrol 2019 Feb 13;20(1):51. Epub 2019 Feb 13.

Department of Nephrology and Hypertension, Rabin Medical Center, Petah Tikva, Israel.

Background: Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1244-yDOI Listing
February 2019
1 Read

Development and preliminary results on the feasibility of a renal diet specific question prompt sheet for use in nephrology clinics.

BMC Nephrol 2019 Feb 12;20(1):48. Epub 2019 Feb 12.

Department of Clinical Nutrition, Wollongong Hospital, Illawarra Shoalhaven Local Health District, Level 5 Block C, Crown Street, Wollongong, NSW, 2500, Australia.

Background: Adherence to the diet prescription for chronic kidney disease is suboptimal. Interventions to improve dietary adherence suggest that improving communication between the patient and the health professional is fundamental to improving outcomes. Providing patients with a question prompt sheet prior to the consultation has been demonstrated to be an effective method for improving communication between patient and health professional. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1231-3DOI Listing
February 2019

Magnesium lithospermate B improves renal hemodynamics and reduces renal oxygen consumption in 5/6th renal ablation/infarction rats.

BMC Nephrol 2019 Feb 12;20(1):49. Epub 2019 Feb 12.

Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road, Pudong District, Shanghai, 201203, People's Republic of China.

Background: Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia in rats induced by 5/6th renal Ablation/Infarction(A/I).

Methods: Chronic renal failure (CRF) was induced in male SD rats by the 5/6 (A/I) surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1221-5DOI Listing
February 2019
1 Read

Blood volume analysis as a guide for dry weight determination in chronic hemodialysis patients: a crossover study.

BMC Nephrol 2019 Feb 11;20(1):47. Epub 2019 Feb 11.

Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York University School of Medicine, 423 E. 23 St., New York, NY, USA.

Background: Volume overload and depletion both lead to high morbidity and mortality. Achieving euvolemia is a challenge in patients with end stage kidney disease on hemodialysis (HD). Blood volume analysis (BVA) uses radiolabeled albumin to determine intravascular blood volume (BV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1211-7DOI Listing
February 2019

Some nephron progenitors fail to commit.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Nature Reviews Nephrology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0122-yDOI Listing
February 2019

Pre-donation BMI and preserved kidney volume can predict the cohort with unfavorable renal functional compensation at 1-year after kidney donation.

BMC Nephrol 2019 Feb 8;20(1):46. Epub 2019 Feb 8.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensation is critical when baseline kidney function is marginal. We explored the significance of preserved kidney volume (PKV) and known preoperative risk factors for the prediction of unfavorable renal function compensation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368798PMC
February 2019

Cellular signalling by primary cilia in development, organ function and disease.

Nat Rev Nephrol 2019 Feb 7. Epub 2019 Feb 7.

Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark.

Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular cues to regulate diverse cellular processes during development and to maintain tissue homeostasis. The sensory capacity of primary cilia relies on the coordinated trafficking and temporal localization of specific receptors and associated signal transduction modules in the cilium. The canonical Hedgehog (HH) pathway, for example, is a bona fide ciliary signalling system that regulates cell fate and self-renewal in development and tissue homeostasis. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41581-019-0116-9
Publisher Site
http://dx.doi.org/10.1038/s41581-019-0116-9DOI Listing
February 2019
7 Reads

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study.

BMC Nephrol 2019 Feb 7;20(1):45. Epub 2019 Feb 7.

Department of Radiology, Pediatric Radiology, University Hospital of Bonn, Bonn, Germany.

Background: Nephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1233-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367765PMC
February 2019
5 Reads

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Nat Rev Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

Uraemic syndrome (also known as uremic syndrome) in patients with advanced chronic kidney disease involves the accumulation in plasma of small-molecule uraemic solutes and uraemic toxins (also known as uremic toxins), dysfunction of multiple organs and dysbiosis of the gut microbiota. As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple biological pathways are affected, including those controlled by solute carrier (SLC) and ATP-binding cassette (ABC) transporters and drug-metabolizing enzymes, many of which are also involved in drug absorption, distribution, metabolism and elimination (ADME). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0111-1DOI Listing
February 2019
3 Reads

The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa.

BMC Nephrol 2019 Feb 6;20(1):44. Epub 2019 Feb 6.

Division of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Background: The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.

Methods: All included patients had histological evidence of either collapsing or non-collapsing focal segmental glomerulosclerosis (FSGS) or podocyte and/or parietal cell hypertrophy or hyperplasia. All patients had evidence of tubulointerstitial inflammation with microcysts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1208-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366071PMC
February 2019
1 Read

Multidimensional pruritus assessment in hemodialysis patients.

BMC Nephrol 2019 Feb 6;20(1):42. Epub 2019 Feb 6.

Medical Nursing Department, Hacettepe University Faculty of Nursing, Sihhiye/Ankara, Turkey.

Background: Pruritus is a distressing, life-limiting symptom in chronic renal failure, affecting 40% of patients. This study aimed to determine uremic pruritus prevalence and investigate the multidimensional impact on hemodialysis patients.

Methods: This descriptive study was performed between March and June 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1234-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366049PMC
February 2019
1 Read

Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report.

BMC Nephrol 2019 Feb 6;20(1):43. Epub 2019 Feb 6.

Department of Nephrology, Okazaki City Hospital, 3-1 Goshoai Koryuzi-cho, Okazaki, Aichi, 444-8553, Japan.

Background: Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy. However, there are few case reports on THSD7A-associated MN with malignancy, and details of its characteristics have not been clarified thoroughly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366086PMC
February 2019
1 Read

Impact of thyroid function on cystatin C in detecting acute kidney injury: a prospective, observational study.

BMC Nephrol 2019 Feb 6;20(1):41. Epub 2019 Feb 6.

Department of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, 96 Dongchuan Road, Guangzhou, 510080, Guangdong Province, People's Republic of China.

Background: Cystatin C (Cys C) used clinically for detecting early acute kidney injury (AKI) was reported to be associated with thyroid function. Therefore, whether the performance of Cys C is affected by thyroid hormones has raised concern in critically ill patients. This study aimed to investigate the impact of thyroid hormones on the diagnostic and predictive accuracy of Cys C for AKI, and hence optimize the clinical application of Cys C. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1201-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364411PMC
February 2019
1 Read

Burden, access and disparities in kidney disease.

Nephrology (Carlton) 2019 Feb 6. Epub 2019 Feb 6.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13557DOI Listing
February 2019
1 Read

Quality of life in caregivers compared with dialysis recipients: the Co-ACTIVE sub-study of the ACTIVE Dialysis trial.

Nephrology (Carlton) 2019 Feb 5. Epub 2019 Feb 5.

The George Institute for Global Health, UNSW, Sydney, Australia.

Aim: To compare quality of life (QOL) of caregivers of dialysis patients with the cared for patients and population norms.

Methods: The ACTIVE Dialysis study randomised participants to extended (median 24 hours/week) or standard (median 12 hours/week) haemodialysis hours for 12 months. A subgroup of participants and their nominated caregivers completed QOL questionnaires including the EuroQOL-5 Dimension-3 Level (EQ5D-3L), Short Form-36 (SF-36, also allowing estimation of the SF-6D), as well as a bespoke questionnaire and the Personal Wellbeing Index (PWI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13530DOI Listing
February 2019
1 Read

Kidney disease in the Global Burden of Disease Study 2017.

Nat Rev Nephrol 2019 Feb 5. Epub 2019 Feb 5.

School of Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0120-0DOI Listing
February 2019

Hypoxia causes important changes of extracellular matrix biomarkers and ADAMTS proteinases in the adriamycin-induced renal fibrosis model.

Nephrology (Carlton) 2019 Feb 4. Epub 2019 Feb 4.

Department of Biochemistry, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey.

Aim: Renal fibrosis is a common cause of renal dysfunction with chronic kidney diseases. This process is characterized by excessive production of extracellular matrix (ECM) or inhibition of ECM degradation. ADAMTS proteinases, which are widely presented in mammals, have very critical roles in ECM remodeling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13572DOI Listing
February 2019

Impact of acute kidney injury in expanded criteria deceased donors on post-transplant clinical outcomes: multicenter cohort study.

BMC Nephrol 2019 Feb 4;20(1):39. Epub 2019 Feb 4.

Transplant Research Center, Seoul, South Korea.

Background: The problem of organ shortage is an important issue in kidney transplantation, but the effect of kidney donation on AKI is unclear. The aim of this study was to investigate the impact of acute kidney injury (AKI) on post-transplant clinical outcomes for deceased donor kidney transplantation (DDKT) using standard criteria donors (SCDs) versus expanded criteria donors (ECDs).

Methods: Five-hundred nine KT recipients receiving kidneys from 386 deceased donors (DDs) were included from three transplant centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1225-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360778PMC
February 2019
1 Read

Outcome of kidney function after ischaemic and zero-ischaemic laparoscopic and open nephron-sparing surgery for renal cell cancer.

BMC Nephrol 2019 Feb 4;20(1):40. Epub 2019 Feb 4.

Department of Urology, Charité - University Hospital, Berlin, Germany.

Background: Nephron-sparing surgery (NSS) remains gold standard for the treatment of localised renal cell cancer (RCC), even in case of a normal contralateral kidney. Compared to radical nephrectomy, kidney failure and cardiovascular events are less frequent with NSS. However, the effects of different surgical approaches and of zero ischaemia on the postoperative reduction in renal function remain controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1215-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362593PMC
February 2019
1 Read

A randomized controlled trial of different serum phosphate ranges in subjects on hemodialysis.

BMC Nephrol 2019 Feb 4;20(1):37. Epub 2019 Feb 4.

Manchester Academic Health Science Center, Manchester, UK.

Background: Hyperphosphataemia in dialysis subjects is associated with increased mortality. However cause and effect has not been proven, and the ideal phosphate target range is unknown despite KDOQI's call for studies over 12 years ago. The design and conduct of a randomized controlled trial is challenging because maintaining two groups within differing target ranges of serum phosphate has not been achieved over a long follow-up of 1 year, in a trial setting, before. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1216-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360717PMC
February 2019
1 Read

The views and experiences of older people with conservatively managed renal failure: a qualitative study of communication, information and decision-making.

BMC Nephrol 2019 Feb 4;20(1):38. Epub 2019 Feb 4.

Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.

Background: Older people with advanced kidney disease require information and support from clinicians when deciding whether to have dialysis or conservative (non-dialysis) care. There is evidence that communication practices, information provision and treatment rates vary widely across renal units. However, experiences of communicating with clinicians among patients receiving conservative care are poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1230-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360769PMC
February 2019
2 Reads

A prospective study of daclatasvir and sofosbuvir in chronic HCV-infected kidney transplant recipients.

BMC Nephrol 2019 Feb 4;20(1):36. Epub 2019 Feb 4.

Department of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Augustenburger Platz, 13353, Berlin, Germany.

Background: Only a few prospective trials exist regarding the use of novel direct-acting antiviral agents (DAAs) in kidney transplant recipients (KTR) with chronic hepatitis C virus (HCV) infection.

Methods: This prospective single-center trial evaluated treatment with daclatasvir (DCV) and sofosbuvir (SOF) over 12 weeks in 16 adult chronic HCV infected KTR and eGFR > 30 ml/min/1.73m. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1218-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360788PMC
February 2019
1 Read

Outcomes and practice patterns with hemodiafiltration in Shanghai: a longitudinal cohort study.

BMC Nephrol 2019 Feb 1;20(1):34. Epub 2019 Feb 1.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Background: Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF practice patterns and associated mortality risk in Shanghai. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-019-1219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359843PMC
February 2019
4 Reads

Clinical outcomes of hemodialysis patients in a public-private partnership care framework in Italy: a retrospective cohort study.

BMC Nephrol 2019 Feb 1;20(1):35. Epub 2019 Feb 1.

Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.

Background: Innovative care models such as public-private partnerships (PPPs) may help meet the challenge of providing cost-effective high-quality care for the steadily growing and complex chronic kidney disease population since they combine the expertise and efficiency of a specialized dialysis provider with the population care approach of a public entity. We report the five-years main clinical outcomes of a population of patients treated on hemodialysis within a PPP-care model in Italy.

Methods: This descriptive retrospective cohort study consisted of all consecutive hemodialysis patients treated in the NephroCare-operated Nephrology and Dialysis unit of the Seriate Hospital in 2012-2016, which exercises a PPP-care model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1224-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359808PMC
February 2019

Bioimpedance spectroscopy-guided fluid management in peritoneal dialysis patients with residual kidney function: a randomized controlled trial.

Nephrology (Carlton) 2019 Jan 31. Epub 2019 Jan 31.

Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine.

Aim: Bioimpedance spectroscopy (BIS) allows volume status to be assessed objectively. This study evaluated the effect of BIS-guided fluid management on residual kidney function (RKF), volume status, and cardiovascular events in peritoneal dialysis (PD) patients.

Methods: A multicenter, prospective, randomized, controlled trial was conducted over 12 months in 2013-2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13571DOI Listing
January 2019

The genetic changes of Wilms tumour.

Nat Rev Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Wellcome Sanger Institute, Cambridge, UK.

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41581-019-0112-0DOI Listing
January 2019

Long term metabolic and renal outcomes of kidney donors compared to controls with excellent kidney function.

BMC Nephrol 2019 Jan 31;20(1):30. Epub 2019 Jan 31.

Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Only few studies of living kidney donors have included controls that were similarly healthy, including excellent kidney function.

Methods: In this study, we aimed to estimate long term metabolic and renal outcome in a cohort of 211 living donors compared to two control groups: paired-matched controls, and another control group of 2534 healthy individuals with excellent kidney function.

Results: Donors presented with higher estimated Glomerular Filtration Rate (eGFR): (97. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1214-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357355PMC
January 2019
1 Read

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

BMC Nephrol 2019 Jan 31;20(1):29. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Foothills Medical Center, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada.

Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies. Recently, patients with linear IgG IF staining, undetectable circulating anti-GBM antibodies and glomerular changes atypical for anti-GBM disease have been described as "atypical anti-GBM disease", with a distinctly more benign clinical course than typical anti-GBM disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357502PMC
January 2019
2 Reads

The value of maintaining normokalaemia and enabling RAASi therapy in chronic kidney disease.

BMC Nephrol 2019 Jan 31;20(1):31. Epub 2019 Jan 31.

Department of Cardiology, Royal Free Hospital, London, UK.

Background: People with chronic kidney disease (CKD) are at an increased risk of developing hyperkalaemia due to their declining kidney function. In addition, these patients are often required to reduce or discontinue guideline-recommended renin-angiotensin-aldosterone system inhibitor (RAASi) therapy due to increased risk of hyperkalaemia. This original research developed a model to quantify the health and economic benefits of maintaining normokalaemia and enabling optimal RAASi therapy in patients with CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1228-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357372PMC
January 2019
1 Read

Electronic health records accurately predict renal replacement therapy in acute kidney injury.

BMC Nephrol 2019 Jan 31;20(1):32. Epub 2019 Jan 31.

Division of Nephrology, University Medicine Cluster, National University Hospital, Level 10 Medicine Office, NUHS Tower Block, 1E Kent Ridge Road, Singapore, 119228, Singapore.

Background: Electronic health records (EHR) detect the onset of acute kidney injury (AKI) in hospitalized patients, and may identify those at highest risk of mortality and renal replacement therapy (RRT), for earlier targeted intervention.

Methods: Prospective observational study to derive prediction models for hospital mortality and RRT, in inpatients aged ≥18 years with AKI detected by EHR over 1 year in a tertiary institution, fulfilling modified KDIGO criterion based on serial serum creatinine (sCr) measures.

Results: We studied 3333 patients with AKI, of 77,873 unique patient admissions, giving an AKI incidence of 4%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1206-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357378PMC
January 2019
1 Read

The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation.

BMC Nephrol 2019 Jan 31;20(1):33. Epub 2019 Jan 31.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation.

Methods: This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1222-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357388PMC
January 2019
1 Read

Acute kidney injury in patients with myocardial infarction undergoing percutaneous coronary intervention using radial versus femoral access.

BMC Nephrol 2019 Jan 30;20(1):28. Epub 2019 Jan 30.

Division of Internal Medicine, Department of Cardiology and Angiology, University Medical Center Maribor, Ljubljanska ulica 5, 2000, Maribor, Slovenia.

Background: Data on radial access (RA) as an independent risk factor for acute kidney injury (AKI) in myocardial infarction (MI) patients are conflicting. Our aim was to assess how RA influences the incidence of AKI in MI patients undergoing percutaneous coronary intervention (PCI).

Methods: Data from 3842 MI patients undergoing PCI at our institution from January 2011 to December 2016, of which 35. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1210-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354416PMC
January 2019

FGF-23 in untreated nephrotic syndrome and effects of the renin-angiotensin-aldosterone system.

Authors:
Michael Pazianas

Nephrology (Carlton) 2019 Feb;24(2):273

Department of Orthopaedics, Rheumatology and Musculoskeletal Diseases, Institute of Musculoskeletal Sciences, Oxford University, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13266DOI Listing
February 2019
1 Read

A rare diagnosis of primary native kidney non-hodgkin's lymphoma after kidney transplantation.

Nephrology (Carlton) 2019 Feb;24(2):272

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nep.13426DOI Listing
February 2019

Hemophagocytic lymphohistiocytosis followed by an episode of peritoneal dialysis associated peritonitis: a case report.

BMC Nephrol 2019 Jan 29;20(1):27. Epub 2019 Jan 29.

Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China; and Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, 8 Xishiku Street; Xicheng District, Beijing, China.

Background: Hemophagocytic lymphohistiocytosis (HLH) is characterized by excessive activation of the immune system due to infection, autoimmune diseases, or malignancy. As an aggressive and life-threatening clinical syndrome, HLH secondary to peritoneal dialysis associated peritonitis (PDAP) has never been reported.

Case Presentation: A 34-year-old female peritoneal dialysis (PD) patient was hospitalized for fever, progressively multi-organ damage (including cytopenias, abnormalities of coagulation and liver enzyme) after an episode of organism-specific peritonitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1217-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352365PMC
January 2019

"Knowledge is power" - A framework for partnering with consumers in developing and delivering a scientific meeting in nephrology.

Nephrology (Carlton) 2019 Jan 29. Epub 2019 Jan 29.

Australia and New Zealand Dialysis and Transplant Registry, South Australian Health and Medical Research Institute, SA, Australia.

Involving consumers (patients, carers and family members) across all stages of research is gaining momentum in the nephrology community. Scientific meetings present a partnership opportunity with consumers for dissemination of research findings. The Better Evidence And Translation - Chronic Kidney Disease (BEAT-CKD) research collaboration, in partnership with Kidney Health Australia, convened two consumer sessions at the 54th Australian and New Zealand Society of Nephrology Annual Scientific Meeting held in September 2018. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/nep.13570
Publisher Site
http://dx.doi.org/10.1111/nep.13570DOI Listing
January 2019
3 Reads