7,239 results match your criteria Nephrology [Journal]


Obesity, kidney dysfunction and hypertension: mechanistic links.

Nat Rev Nephrol 2019 Apr 23. Epub 2019 Apr 23.

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

Excessive adiposity raises blood pressure and accounts for 65-75% of primary hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity, abnormal kidney function and associated increases in tubular sodium reabsorption initiate hypertension, which is often mild before the development of target organ injury. Factors that contribute to increased sodium reabsorption in obesity include kidney compression by visceral, perirenal and renal sinus fat; increased renal sympathetic nerve activity (RSNA); increased levels of anti-natriuretic hormones, such as angiotensin II and aldosterone; and adipokines, particularly leptin. Read More

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http://dx.doi.org/10.1038/s41581-019-0145-4DOI Listing

Modelling the long-term benefits of tolvaptan therapy on renal function decline in autosomal dominant polycystic kidney disease: an exploratory analysis using the ADPKD outcomes model.

BMC Nephrol 2019 Apr 23;20(1):136. Epub 2019 Apr 23.

Otsuka Pharmaceutical Europe Ltd, Gallions Wexham Springs, Framewood Road, Wexham, SL3 6PJ, UK.

Background: The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represents a validated approach to predict natural disease progression over a lifetime horizon. This study describes the implementation of a tolvaptan treatment effect within the ADPKD-OM and explores the potential long-term benefits of tolvaptan therapy in ADPKD.

Methods: The effect of tolvaptan on ADPKD progression was modelled by applying a constant treatment effect to the rate of renal function decline, consistent with that observed in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes trial (TEMPO 3:4; ClinicalTrials. Read More

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http://dx.doi.org/10.1186/s12882-019-1290-5DOI Listing

Recruitment and participant baseline characteristics in the dialysis outcomes in those aged 65 years or older study.

BMC Nephrol 2019 Apr 23;20(1):137. Epub 2019 Apr 23.

Department of Medicine, University of Otago, Dunedin, New Zealand.

Background: Despite an increasing number of older people commencing dialysis the impact of dialysis on their quality of life and survival, remains unclear. The Dialysis Outcomes in those aged over 65 years or older study is an accelerated prospective cohort longitudinal design study, designed to obtain sufficient health related quality of life data, linked to clinical data, to inform clinicians' and patients' decision-making with respect to end stage kidney disease (ESKD), outcomes, and options for management in New Zealand (NZ).

Methods: The study has an accelerated prospective cohort longitudinal design, comprised of cross-sectional and longitudinal components. Read More

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http://dx.doi.org/10.1186/s12882-019-1328-8DOI Listing

Hyponatremia may be an under-recognized complication after desmopressin to reduce uremic bleeding in kidney biopsy.

Nephrology (Carlton) 2019 Apr 21. Epub 2019 Apr 21.

Department of Renal Medicine, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1111/nep.13398DOI Listing

Measuring fibrosis without biopsies.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Apr 18. Epub 2019 Apr 18.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0153-4DOI Listing

Long-term peritoneal dialysis followed by kidney transplantation for Takayasu arteritis: a case report.

BMC Nephrol 2019 Apr 18;20(1):131. Epub 2019 Apr 18.

Division of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo, 150-8935, Japan.

Background: Takayasu arteritis (TA) is a chronic vasculitis of unknown etiology that primarily affects large vessels. Although renal involvement is frequent in TA, patients with TA undergoing renal replacement therapy, especially long-term peritoneal dialysis (PD) and kidney transplantation (KTx), are rarely reported. We herein present the case of an elderly patient with TA treated by PD for more than 5 years and underwent KTx thereafter. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1302-5DOI Listing
April 2019
4 Reads

S1PR2 antagonist ameliorate high glucose-induced fission and dysfunction of mitochondria in HRGECs via regulating ROCK1.

BMC Nephrol 2019 Apr 18;20(1):135. Epub 2019 Apr 18.

Center for Experimental Medical Research, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, Hunan, 410013, People's Republic of China.

Aims: Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothelial cell dysfunction remains unclear. This study aims to investigate the effect of S1PR2 blockade on the morphology and function of mitochondria in human renal glomerular endothelial cells (HRGECs). Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1323-0DOI Listing
April 2019
1 Read

Associations of serum and dialysate electrolytes with QT interval and prolongation in incident hemodialysis: the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) study.

BMC Nephrol 2019 Apr 18;20(1):133. Epub 2019 Apr 18.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concentrations of calcium, potassium, and magnesium with corrected QT (QTc) prolongation in incident hemodialysis patients.

Methods: In 330 in-center hemodialysis participants from the PACE study who were followed up for one year, we examined the associations of predialysis serum electrolytes (total calcium [Ca], corrected Ca [cCa], ionized Ca [iCa], potassium [K], magnesium [Mg]), dialysate (dCa and dK), and serum-to-dialysate gradient measures with QTc interval and prolongation (≥460 ms in women and ≥ 450 ms in men).

Results: At the first study visit, 47% had QTc prolongation. Read More

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http://dx.doi.org/10.1186/s12882-019-1282-5DOI Listing
April 2019
1 Read

Improving proteinuria screening with mailed smartphone urinalysis testing in previously unscreened patients with hypertension: a randomized controlled trial.

BMC Nephrol 2019 Apr 18;20(1):132. Epub 2019 Apr 18.

Geisinger Health System, Department of Nephrology, 100 N Academy Ave, Danville, PA17822, USA.

Background: Proteinuria screening is recommended for patients with hypertension to screen for kidney disease and identify those at elevated risk for cardiovascular disease. However, screening rates among hypertensive patients are low. Home testing strategies may be useful in improving proteinuria screening adherence. Read More

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http://dx.doi.org/10.1186/s12882-019-1324-zDOI Listing

NAV-KIDS trial: protocol for a multi-centre, staggered randomised controlled trial of a patient navigator intervention in children with chronic kidney disease.

BMC Nephrol 2019 Apr 18;20(1):134. Epub 2019 Apr 18.

Centre for Kidney Research at The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There is growing evidence of socioeconomic disparities in health outcomes among children with CKD. Patient navigators are trained non-medical personnel who assist patients with chronic conditions journey through the continuum of care and transit across different care settings. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1325-yDOI Listing
April 2019
2 Reads

Intracranial hypertension in a patient with Class V lupus nephritis.

Nephrology (Carlton) 2019 May;24(5):585

Department of Nephrology, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/nep.13432DOI Listing
May 2019
1 Read

Corrigendum.

Authors:

Nephrology (Carlton) 2019 May;24(5):586

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http://dx.doi.org/10.1111/nep.13590DOI Listing

Immune-based combination therapy for metastatic kidney cancer.

Nat Rev Nephrol 2019 Apr 16. Epub 2019 Apr 16.

Division of Translational Oncology, IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy.

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http://dx.doi.org/10.1038/s41581-019-0149-0DOI Listing

Association between prediabetes (defined by HbA1, fasting plasma glucose, and impaired glucose tolerance) and the development of chronic kidney disease: a 9-year prospective cohort study.

BMC Nephrol 2019 Apr 16;20(1):130. Epub 2019 Apr 16.

Division of Cardiology, Department of Internal Medicine, Sanggye Paik Hospital, Inje University, Dongil-ro 1342, Nowon-gu, Seoul, 01757, South Korea.

Background: The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and Epidemiology Study.

Methods: This prospective cohort study included 7728 Korean adults without baseline CKD and type 2 diabetes. Prediabetes was defined by impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and HbA1 level. Read More

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http://dx.doi.org/10.1186/s12882-019-1307-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469043PMC
April 2019
1 Read

Unique metabolic traits identify CCPAP.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Nature Reviews Nephrology, .

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http://www.nature.com/articles/s41581-019-0151-6
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http://dx.doi.org/10.1038/s41581-019-0151-6DOI Listing
April 2019
1 Read

Predictors of short-term successful discontinuation of continuous renal replacement therapy: results from a prospective multicentre study.

BMC Nephrol 2019 Apr 15;20(1):129. Epub 2019 Apr 15.

Department of Intensive Care, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Background: Prediction of successful discontinuation of continuous renal replacement therapy (CRRT) might reduce complications of over- and under-treatment. The aim of this study was to identify renal and non-renal predictors of short-term successful discontinuation of CRRT in patients in whom CRRT was stopped because renal recovery was expected and who were still in the Intensive Care Unit (ICU) at day 2 after stop CRRT.

Methods: Prospective multicentre observational study in 92 patients alive after discontinuation of CRRT for acute kidney injury (AKI), still in the ICU and free from renal replacement therapy (RRT) at day 2 after discontinuation. Read More

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http://dx.doi.org/10.1186/s12882-019-1327-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466643PMC
April 2019
1 Read

Secular trends in end-stage kidney disease requiring renal replacement therapy in Japan: Japanese Society of Dialysis Therapy Registry data from 1983 to 2016.

Nephrology (Carlton) 2019 Apr 13. Epub 2019 Apr 13.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.

Aim: We aimed to describe secular trends in the incidence of end stage kidney disease (ESKD) requiring renal replacement therapy (RRT) in Japan, and to assess the effect of population aging on the incidence of ESKD.

Methods: The national incidence of ESKD requiring RRT was calculated using published data and Japan's population statistics. Age-standardized incidence was calculated by direct standardization using the World Standard Population. Read More

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http://dx.doi.org/10.1111/nep.13595DOI Listing

Bone Turnover Markers Predict Type of Bone Histomorphometry and Bone Mineral Density in Asian Chronic Hemodialysis Patients.

Nephrology (Carlton) 2019 Apr 13. Epub 2019 Apr 13.

Division of Nephrology, Department of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital.

Background: Although the levels of intact parathyroid hormone (iPTH) are well-controlled following the KDIGO guideline, the incidence of osteoporosis and fracture are still high in hemodialysis (HD) patients. This study was conducted to investigate the correlation between bone turnover markers, bone mineral density (BMD), and bone histomorphometry in HD patients.

Methods: Twenty-two chronic HD patients were enrolled. Read More

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http://dx.doi.org/10.1111/nep.13593DOI Listing
April 2019
1 Read

Is IgA Nephropathy Different in Different Ethnic Populations?

Nephrology (Carlton) 2019 Apr 11. Epub 2019 Apr 11.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

IgA nephropathy (IgAN) is one of the commonest global patterns of primary glomerulonephritis and remains a leading cause of chronic kidney disease and end stage renal disease. The sole diagnostic criterion of IgAN remains the presence of dominant mesangial IgA deposits on kidney biopsy. Beyond this defining feature, there is significant heterogeneity in the epidemiology, clinical presentation, renal progression and long term outcomes of IgAN in different ethnic populations. Read More

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http://dx.doi.org/10.1111/nep.13592DOI Listing
April 2019
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miR-10b suppresses cell invasion and metastasis through targeting HOXA3 regulated by FAK/YAP signaling pathway in clear-cell renal cell carcinoma.

BMC Nephrol 2019 Apr 11;20(1):127. Epub 2019 Apr 11.

Department of Urology, Xiangya Hospital, Central South University, No. 87, Xiangya Road, Changsha, 410000, Hunan Province, People's Republic of China.

Background: MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. However, the direct target of miR-10b in ccRCC and the related molecular mechanisms has not yet been revealed. Read More

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http://dx.doi.org/10.1186/s12882-019-1322-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458703PMC
April 2019
1 Read

Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis.

BMC Nephrol 2019 Apr 11;20(1):128. Epub 2019 Apr 11.

The Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Rd, Hangzhou, Zhejiang, 310003, People's Republic of China.

Background: Mitochondrial DNA (mtDNA) released into extracellular subsequent to cell injury and death can promote inflammation in patients and animal models. However, the effects of peritoneal dialysate cell-free mtDNA on intraperitoneal inflammation and peritoneal solute transport rate (PSTR) in peritoneal dialysis (PD) patients remain unclear.

Methods: We select the incident patients who began PD therapy between January 1, 2009, and December 30, 2010. Read More

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http://dx.doi.org/10.1186/s12882-019-1284-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458606PMC

Novel homozygous OSGEP gene pathogenic variants in two unrelated patients with Galloway-Mowat syndrome: case report and review of the literature.

BMC Nephrol 2019 Apr 11;20(1):126. Epub 2019 Apr 11.

Molecular Biology Laboratory, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Cartagena 340-350, 08025, Barcelona, Catalonia, Spain.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies. WDR73 pathogenic variants were described as the first genetic cause of GAMOS and, very recently, four novel causative genes, OSGEP, LAGE3, TP53RK, and TPRKB, have been identified.

Case Presentation: We present the clinical and genetic characteristics of two unrelated infants with clinical suspicion of GAMOS who were born from consanguineous parents. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1317-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458604PMC
April 2019
2 Reads

Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.

BMC Nephrol 2019 Apr 10;20(1):125. Epub 2019 Apr 10.

Division of Pediatric Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA.

Background: There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of patients with aHUS treated with eculizumab.

Methods: Patients with aHUS who participated in any of five parent eculizumab trials and received at least one eculizumab infusion were eligible for enrollment in a long-term follow-up study. Read More

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http://dx.doi.org/10.1186/s12882-019-1314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456946PMC
April 2019
1 Read

Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study.

BMC Nephrol 2019 Apr 8;20(1):122. Epub 2019 Apr 8.

Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, School of Medical Sciences, Kumasi, Ghana.

Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana. Read More

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http://dx.doi.org/10.1186/s12882-019-1316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454740PMC
April 2019
1 Read

IL17A and IL17F genes polymorphisms are associated with histopathological changes in transplanted kidney.

BMC Nephrol 2019 Apr 8;20(1):124. Epub 2019 Apr 8.

Department of Physiology, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111, Szczecin, Poland.

Background: Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated that the rs2275913 IL17A and the rs11465553 IL17F gene polymorphism are associated with kidney allograft function. Read More

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http://dx.doi.org/10.1186/s12882-019-1308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454731PMC
April 2019
1 Read

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

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http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454690PMC
April 2019
1 Read

Impact of salt taste dysfunction on interdialytic weight gain for hemodialysis patients; a cross-sectional study.

BMC Nephrol 2019 Apr 5;20(1):121. Epub 2019 Apr 5.

Department of Nephrology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Little is known about salt taste dysfunction among hemodialysis (HD) patients. This study aimed to elucidate the prevalence of salt taste dysfunction and its relationship with interdialytic weight gain (IDWG) among HD patients.

Methods: A single-center cross-sectional study involving 99 maintenance HD patients was conducted in September 2015. Read More

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http://dx.doi.org/10.1186/s12882-019-1312-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451217PMC

Structure and function of polycystins: insights into polycystic kidney disease.

Nat Rev Nephrol 2019 Apr 4. Epub 2019 Apr 4.

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Institut de Pharmacologie Moléculaire et Cellulaire, Labex ICST, Valbonne, France.

Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid-filled renal cysts that disrupt renal architecture and function, ultimately leading to kidney failure in the majority of patients. Although the genetic basis of ADPKD is now well established, the physiological function of polycystins remains obscure and a matter of intense debate. The structural determination of both the homomeric PC2 and heteromeric PC1-PC2 complexes, as well as the electrophysiological characterization of PC2 in the primary cilium of renal epithelial cells, provided new valuable insights into the mechanisms of ADPKD pathogenesis. Read More

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http://www.nature.com/articles/s41581-019-0143-6
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http://dx.doi.org/10.1038/s41581-019-0143-6DOI Listing
April 2019
6 Reads

Serum klotho is inversely associated with metabolic syndrome in chronic kidney disease: results from the KNOW-CKD study.

BMC Nephrol 2019 Apr 3;20(1):119. Epub 2019 Apr 3.

Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Korea.

Background: Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. Read More

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http://dx.doi.org/10.1186/s12882-019-1297-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446407PMC
April 2019
1 Read

Urinary angiostatin: a novel biomarker of kidney disease associated with disease severity and progression.

BMC Nephrol 2019 Apr 3;20(1):118. Epub 2019 Apr 3.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, 100853, China.

Background: This study aimed to evaluate the value of urinary angiostatin levels for assessing disease severity and progression of IgA nephropathy (IgAN).

Methods: Urinary angiostatin was identified as one of the distinct proteins in samples of patients with IgAN analyzed by Raybiotech protein array, and further confirmed by enzyme-linked immunosorbent assay (ELISA).

Results: Urinary angiostatin levels were significantly higher in IgAN patients than that in healthy controls (HC) subjects and lower than in disease controls (DC) patients. Read More

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http://dx.doi.org/10.1186/s12882-019-1305-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446319PMC
April 2019
2 Reads
1.520 Impact Factor

Small intestinal perforation due to a huge gastrointestinal stromal tumor in a kidney transplant recipient: a case report and literature review.

BMC Nephrol 2019 Apr 3;20(1):120. Epub 2019 Apr 3.

Department of Urology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Background: Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant recipient with perforation of small intestine.

Case Presentation: A 64-year-old male presented at our hospital with right colic pain; he had received an ABO incompatible kidney transplant 6 years earlier and was treated with cyclosporine, mycophenolate mofetil, and methylprednisolone. Read More

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http://dx.doi.org/10.1186/s12882-019-1310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448240PMC
April 2019
3 Reads
1.520 Impact Factor

A need-based approach to self-management education for adults with co-morbid diabetes and chronic kidney disease.

BMC Nephrol 2019 Apr 2;20(1):113. Epub 2019 Apr 2.

School of Public Health and Preventive Medicine, Monash University, Alfred Centre, 99 Commercial Road, Melbourne, 3004, Australia.

Background: Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the self-management education needs for patients with co-morbid diabetes and CKD and 2) co-develop an educational resource meeting the self-management education needs of patients with co-morbid diabetes and CKD.

Methods: Patients with co-morbid diabetes and CKD attending a co-designed, patient-centred outpatient diabetes and kidney clinic at a tertiary metropolitan hospital were recruited for semi-structured interviews. Read More

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http://dx.doi.org/10.1186/s12882-019-1296-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444589PMC
April 2019
1.520 Impact Factor

Phenprocoumon based anticoagulation is an underestimated factor in the pathogenesis of calciphylaxis.

BMC Nephrol 2019 Apr 2;20(1):114. Epub 2019 Apr 2.

Department of Nephrology, University Hospital of Marburg, UKGM GmbH, Baldingerstraße 1, 35033, Marburg, Germany.

Background: Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evaluation of such factors may be obscured when calciphylaxis diagnosis is based just on clinical features. Read More

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http://dx.doi.org/10.1186/s12882-019-1301-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444830PMC
April 2019
4 Reads

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study.

BMC Nephrol 2019 Apr 2;20(1):117. Epub 2019 Apr 2.

Cohort Study Team, Center for Cluster Development and Coordination, Foundation for Biomedical Research and Innovation at Kobe, 2-2 Minatojima Minamimachi, Chuo-ku, Hyogo, 650-0047, Japan.

Background: Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate estimated glomerular filtration rate (eGFR). We aimed to clarify the relationship between SUA levels and kidney function assessed by cystatin C in a Japanese general community population without chronic kidney disease (CKD).

Methods: We conducted a community-based cross-sectional study that included 1086 healthy participants, aged 40-74 years, without CKD and not undergoing treatment of hyperuricemia, who had participated in the baseline survey of the Kobe Orthopedic and Biomedical Epidemiological (KOBE) study. Read More

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http://dx.doi.org/10.1186/s12882-019-1291-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446294PMC
April 2019
2 Reads

Patient-reported advantages and disadvantages of peritoneal dialysis: results from the PDOPPS.

BMC Nephrol 2019 Apr 2;20(1):116. Epub 2019 Apr 2.

St. Michael's Hospital, Toronto, ON, Canada.

Background: Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the advantages and disadvantages of PD and clinical outcomes.

Methods: In this cohort study, 2760 PD patients in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) completed a questionnaire on their PD experience, between 2014 and 2017. Read More

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http://dx.doi.org/10.1186/s12882-019-1304-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446371PMC
April 2019
1 Read

Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study.

BMC Nephrol 2019 Apr 2;20(1):115. Epub 2019 Apr 2.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: Blood urea nitrogen (BUN) is one of the substances that affects the calculated serum osmolality (cSosm). A previous study demonstrated that BUN and cSosm were independently associated with the development of chronic kidney disease (CKD) in patients with preserved kidney function. In advanced CKD stages, there is a concomitant increase in cSosm and BUN levels. Read More

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http://dx.doi.org/10.1186/s12882-019-1306-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444850PMC
April 2019
1 Read

VE-PTP phosphatase: a new target for diabetic kidney disease.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0147-2DOI Listing

A novel SGLT1-mediated mechanism of hyperglycaemia-induced hyperfiltration.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Apr 1. Epub 2019 Apr 1.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0146-3DOI Listing
April 2019
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Use of the KDQOL-36™ for assessment of health-related quality of life among dialysis patients in the United States.

BMC Nephrol 2019 Apr 1;20(1):112. Epub 2019 Apr 1.

DaVita Clinical Research, 825 S 8th St, Minneapolis, MN, 55404, USA.

Background: Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) survey is widely used for this assessment. KDQOL-36™ completion rates, and the distributions of scores and item responses, have not been examined in a large, nationally representative cohort of dialysis patients. Read More

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http://dx.doi.org/10.1186/s12882-019-1295-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444438PMC

Natalia Tomilina - personality and profession.

Authors:
Elena Zakharova

BMC Nephrol 2019 Apr 1;20(1):111. Epub 2019 Apr 1.

Nephrology, Moscow City Hospital n.a. S.P. Botkin, Moscow, Russian Federation.

Natalina Tomilina, a pioneer of Russian nephrology, is a clinician, researcher, teacher, organizer, leader, and a real pioneer, who has worked in nephrology from the very beginning of its development in Russia and continues to inspire new generations of Russian nephrologists. Her interests are very broad: from the physiology and pathophysiology of water and electrolyte balance and tubular dysfunctions to the management of transplant rejection, and from nephropathology to the treatment of idiopathic glomerulonephritis and ANCA-associated vasculitis…. to name a few. Read More

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http://dx.doi.org/10.1186/s12882-019-1303-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442427PMC

Increased cancer risk in patients undergoing dialysis: a population-based cohort study in North-Eastern Italy.

BMC Nephrol 2019 Mar 28;20(1):107. Epub 2019 Mar 28.

Cancer Epidemiology Unit, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, via Franco Gallini 2, 33081, Aviano, (PN), Italy.

Background: In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo malignancies (DNMs) among dialysis patients in the Friuli Venezia Giulia region, north-eastern Italy.

Methods: A population-based cohort study among 3407 dialysis patients was conducted through a record linkage between local healthcare databases and the cancer registry (1998-2013). Read More

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http://dx.doi.org/10.1186/s12882-019-1283-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437907PMC
March 2019
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Living-donor transplantation leads to a major improvement in physical functioning: an observational study on the impact on potential donors and their recipients.

BMC Nephrol 2019 Mar 29;20(1):109. Epub 2019 Mar 29.

Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center+, PO Box 5800, 6202 AZ, Maastricht, The Netherlands.

Background: Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these parameters between kidney transplant recipients and their living donors by examining changes in these parameters in the first post-operative year in both groups.

Methods: Twenty-two kidney transplant recipients and 22 healthy kidney donors were included in this prospective longitudinal study with a follow-up until twelve months. Read More

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http://dx.doi.org/10.1186/s12882-019-1299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440145PMC

Impact of diabetes on sarcopenia and mortality in patients undergoing hemodialysis.

BMC Nephrol 2019 Mar 28;20(1):105. Epub 2019 Mar 28.

Department of Nephrology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate the onset and progression of sarcopenia. We, therefore, investigated the prevalence of sarcopenia in patients undergoing hemodialysis (HD) and confirmed the impact of diabetes mellitus (DM) on this population. Read More

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http://dx.doi.org/10.1186/s12882-019-1271-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437886PMC

The role of podocyte damage in the etiology of ischemia-reperfusion acute kidney injury and post-injury fibrosis.

BMC Nephrol 2019 Mar 28;20(1):106. Epub 2019 Mar 28.

Department of Nephrology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.

Background: To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims included using the model to explore the role of podocyte injury in AKI and post-injury fibrosis.

Methods: Fifty BALB/C mice were randomly divided into control group (Ctr), sham group (sham), AKI 20 group (renal ischemia, 20 min reperfusion), AKI 30 group (renal ischemia, 30 min reperfusion) and AKI 40 group (renal ischemia, 40 min reperfusion). Read More

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http://dx.doi.org/10.1186/s12882-019-1298-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438002PMC
March 2019
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Patient and provider experience and perspectives of a risk-based approach to multidisciplinary chronic kidney disease care: a mixed methods study.

BMC Nephrol 2019 Mar 29;20(1):110. Epub 2019 Mar 29.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

Methods: The KFRE was implemented to guide access to multidisciplinary care for CKD patients in Alberta, Canada, based on their 2-year risk of kidney failure. We used a mixed methods approach to investigate patients' and providers' perspectives and experiences 1 year following KFRE implementation. Read More

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http://dx.doi.org/10.1186/s12882-019-1269-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440153PMC
March 2019
2 Reads

Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study.

BMC Nephrol 2019 Mar 29;20(1):108. Epub 2019 Mar 29.

Department of Geriatrics, Diakonessenhuis Utrecht, Utrecht, The Netherlands.

Background: Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on quality of life (QoL) in older patients is sparse. In the GOLD (Geriatric assessment in OLder patients starting Dialysis) Study the trajectory of QoL was assessed in patients starting dialysis or MCM. Read More

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http://dx.doi.org/10.1186/s12882-019-1268-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440027PMC
March 2019
1 Read

URAT1 mutations cause renal hypouricaemia combined with Fanconi syndrome in a Chinese patient.

Nephrology (Carlton) 2018 Aug;23(8):797-798

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1111/nep.13190DOI Listing

Novel increasing dose regimen of tolvaptan for autosomal dominant polycystic kidney disease in patient with low tolerability.

Nephrology (Carlton) 2018 Aug;23(8):798-799

Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/nep.13196DOI Listing
August 2018
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Orthostatic proteinuria due to smartphone use in bed.

Nephrology (Carlton) 2018 Aug;23(8):797

Department of Pediatrics, Juntendo University Faculty of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/nep.13170DOI Listing

Non-proteinuric renal al amyloidosis in waldenström's macroglobulinemia.

Nephrology (Carlton) 2019 Apr;24(4):490-491

Nephrology Department, Rouen University Hospital, Normandie University, UNIROUEN, INSERM U1096, Rouen, France.

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http://dx.doi.org/10.1111/nep.13428DOI Listing