8,038 results match your criteria Nephrologie & therapeutique[Journal]


Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology.

Methods Mol Biol 2019 ;1901:271-280

INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.

The innate immune complement system is a powerful defense cascade against pathogens, but can induce host tissue damage when overactivated. In pathological conditions, mainly but not restricted to renal diseases, such as lupus nephritis, atypical hemolytic uremic syndrome, and C3 glomerulopathies, complement is overactivated or dysregulated by autoantibodies directed against its components and regulators. Among the key autoantibody targets are the initiator of the classical complement pathway C1q, the alternative pathway regulator Factor H, the components of the alternative pathway C3 convertase complex C3 and Factor B and the convertase complex itself. Read More

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January 2019

Author Correction: Lipid management in patients with chronic kidney disease.

Nat Rev Nephrol 2018 Dec 11. Epub 2018 Dec 11.

CNR- IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases, Ospedali Riuniti, Italy.

In the acknowledgements section of this article as originally published, information on the authors' roles as EURECAm members is missing. The correct acknowledgement is as follows: "This Review was planned as part of the activity of the European Renal and Cardiovascular Medicine working (EURECAm) group and all authors are EURECAm members. A. Read More

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December 2018

Impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation patients followed in general practices in Germany.

Int J Cardiol 2018 Dec 1. Epub 2018 Dec 1.

Medizinische Klinik 2, St. Vincenz Krankenhaus Paderborn, Germany; Working Group: Molekulare Elektrophysiologie, Universitätsklinik Magdeburg, Magdeburg, Germany. Electronic address:

Background: The goal of this study was to analyze the impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation (AF) patients followed in general practices in Germany.

Methods: This study included patients who had received a first prescription of dronedarone, amiodarone, flecainide, propafenone, or sotalol in 1258 general and 62 cardiology practices between January 2010 and March 2017 (index date). The main outcomes of this study were the percentages of patients with myocardial infarction and stroke in the dronedarone group and in the group of individuals who had received other antiarrhythmic drugs within six years of the index date. Read More

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December 2018

Treatment of cardiac sarcoidosis: A comparative study of steroids and steroids plus immunosuppressive drugs.

Int J Cardiol 2018 Nov 30. Epub 2018 Nov 30.

Département de Médecine Interne, Hôpital Bichat, Université Paris Diderot, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Paris, France; Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France; INSERM U1149, Paris, France. Electronic address:

Background: We aimed to compare the efficacy of steroids alone or associated with immunosuppressive drugs for the prevention of relapse in cardiac sarcoidosis (CS).

Methods: In this monocentric multidisciplinary retrospective single center study, all consecutive patients with histologically proven sarcoidosis hospitalized from January 2012 to December 2016 were considered. All patients with symptomatic CS were studied. Read More

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November 2018

Thesaurus for off-label indications for systemic antifungal agents.

Med Mal Infect 2018 Dec 4. Epub 2018 Dec 4.

Service pharmacie, groupement hospitalier Nord, hospices civils de Lyon, Lyon, France; Comité des anti-infectieux, hospices civils de Lyon, Lyon, France.

Objectives: Following the removal of temporary treatment protocol procedures, we developed a thesaurus for off-label indications for systemic antifungals at our facility to update clinical practices and to control off-label prescriptions.

Materials And Methods: Clinical practice guidelines and literature data were analyzed. This work was part of an antifungal stewardship program. Read More

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December 2018
1 Read

[Current Developments in Nutritional Therapy of Intensive Care Patients].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1759-1764. Epub 2018 Dec 3.

Medizinische Klinik III (Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin) Universitätsklinikum, RWTH-Aachen.

The goals of nutritional therapy for critically ill patients are the enteral or parenteral provision of calories, proteins, electrolytes, vitamins, trace elements and fluids. The metabolism of critically ill patients is characterized by a catabolic stress condition, which is caused by a systemic inflammatory response and is associated with an increased infection rate, occurrence of multiple organ failure and increased mortality.Traditionally, nutritional therapy has been considered as an "adjunctive" therapy for critically ill patients with the primary goal of providing energy to maintain muscle mass. Read More

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December 2018
1 Read

[2018 ESC/ESH Guidelines for the Management of Arterial Hypertension: What's New with Regard to Our Older People?]

Dtsch Med Wochenschr 2018 Dec 3;143(24):1745-1748. Epub 2018 Dec 3.

Klinik für Allgemeine Innere Medizin und Geriatrie, Angiologie, Diabetologie, Endokrinologie, Nephrologie, Krankenhaus Barmherzige Brüder Regensburg.

In the "2018 ESC/ESH Guidelines for the management of arterial hypertension" there are new blood pressure (BP) recommendations with regard to older patients based on randomized controlled trials and well-conducted meta-analyses performed during the last years.It is recommended to base the diagnosis of hypertension on repeated office BP measurements under standardized conditions and in older people in out-of-office BP measurement with ABPM and/or HBPM if logistically and economically feasible. Furthermore lying and standing BP measurements should also be considered in subsequent visits in older people to exclude orthostatic hypotension. Read More

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December 2018

[New Diagnostic Standard in Diabetes Insipidus].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1739-1744. Epub 2018 Dec 3.

Medizinische Klinik III, Klinik für Endokrinologie und Nephrologie, Universitätsklinikum Leipzig.

2018 brings new insights into the differential diagnosis of patients with hypotonic polyuria syndrome. Exact localization of the antidiuretic defect in patients with hypotonic polyuria can be challenging, especially the distinction of primary polydipsia from partial pituitary or renal forms of diabetes insipidus. However, diagnostic precision is vital since therapeutic management differs substantially and false treatment may result in serious consequences. Read More

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December 2018

[Tubulointerstitiel nephritis and Crohn's disease, nephrotoxicity or extraintestinal manifestation of Crohn's disease? About a case].

Nephrol Ther 2018 Nov 29. Epub 2018 Nov 29.

Laboratoire d'anatomie pathologique, CHRU de Nancy, 5, rue de Morvan, 54500 Vandœuvre-lès-Nancy, France.

Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. Read More

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November 2018

Fecal microbiota transplantation to eradicate vancomycin-resistant enterococci colonization in case of an outbreak.

Med Mal Infect 2018 Nov 27. Epub 2018 Nov 27.

Service de maladies infectieuses et tropicales, hôpital Raymond-Poincaré, AP-HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France.

Objective: A rapid and worrying emergence of vancomycin-resistant enterococci (VRE) gut colonization is occurring worldwide and may be responsible for outbreaks, especially in healthcare facilities. While no efficient decolonization strategies are recommended, we assessed fecal microbiota transplantation (FMT) to eradicate VRE colonization.

Patients And Method: Our main objective was to measure the impact of FMT on decolonization of VRE carriers, confirmed by at least two consecutive negative rectal swabs at one-week interval during a 3-month follow-up period. Read More

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November 2018
1 Read

[What is verified in treatment?]

Authors:
H Haller

Internist (Berl) 2018 Dec;59(12):1229

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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December 2018

[Fever in the critically ill : To treat or not to treat].

Authors:
W Druml

Med Klin Intensivmed Notfmed 2018 Nov 28. Epub 2018 Nov 28.

Klinik für Innere Medizin III, Abteilung für Nephrologie, Allgemeines Krankenhaus Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Fever, arbitrarily defined as a core body temperature >38.3 °C, is present in 20-70 % of intensive care unit patients. Fever caused by infections is a physiologic reset of the thermostatic set-point and is associated with beneficial consequences, but may have negative sequelae with temperatures >39. Read More

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November 2018
1 Read

[Renal involvement during monoclonal gammopathies at the teaching hospital of Yopougon in Abidjan, from 2000 to 2016].

Mali Med 2018 ;33(1):6-9

Service de Néphrologie, CHU de Yopougon. Adresse : 21 BP 632 Abidjan 21.

Background: Renal involvement is common during monoclonal gammopathies and their occurrence impacts the survival of the patients. Our objective was to describe the renal features during monoclonal gammopathies from 2004 to 2016 at the University Hospital of Yopougon in Abidjan.

Methods: Renal failure was defined as blood creatinine level > 20 mg/L and/or proteinuria > 500 mg/24 hours. Read More

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January 2018
2 Reads

[CME Sonography 84/Answer: Scrotal Node Palpated].

Authors:
Jan Tuma

Praxis (Bern 1994) 2018 Nov;107(24):1360-1362

1 Ultrasound Learning Center (ULC) der European Federation of Ultrasound in Medicine and Biology (EFSUMB) am Institut für Allgemeine Innere Medizin und Nephrologie, Klinik Hirslanden, Zürich.

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November 2018
1 Read

[What do registries compared to clinical trials tell us?]

Nephrol Ther 2018 Nov;14(6S):6S7-6S11

Service de néphrologie et transplantation, Nouvel Hôpital civil, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67091 Strasbourg, France. Electronic address:

The objective of this review is to illustrate the interests of registries in terms of clinical research, using practical examples from the French REIN registry. In addition to their interest in terms of observation and decision-making for public health, registries may also be used to compare structures, and to evaluate causality in clinical research. Indeed, even though randomized controlled trials are the gold standard to assess causality, they may be difficult to perform, with an applicability in daily life that remains to be demonstrated since patients are highly selected patients with a very close follow-up. Read More

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November 2018
3 Reads

[Metabolic complications in chronic kidney disease: hyperphosphatemia, hyperkalemia and anemia].

Nephrol Ther 2018 Nov;14(6S):6S17-6S25

Service de néphrologie, hôpital Necker-Enfants malades, 149, rue de Sèvres 75015 Paris, France. Electronic address:

Metabolic complications of chronic kidney disease (CKD) are frequent; the aims of this review are to present a 2018 update for hyperkalemia, hyperphosphatemia and anemia. Hyperkalemia is defined by a plasma level above 5.0 mmol/L, after ruling out pre-analytical problems such as hemolysis. Read More

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November 2018
1 Read

[From care management decision to set-up of home dialysis: what are the challenges for the nephrologist in assisting the patient?]

Nephrol Ther 2018 Nov;14(6S):6S12-6S16

Centre universitaire des maladies rénales, CHU de Caen, avenue Côte-de-Nacre, CS 30001, 14033 Caen Cedex 9, France. Electronic address:

Since a couple of years, a new paradigm of care has taken place where the patient plays a major role in the choice of his treatment. Patient information in a context where the doctor-patient relationship has drastically changed and where knowledge is continuously growing, is a challenge for the nephrologist. For the patient who decides to undergo home dialysis, numerous questions arise during the decision-making process. Read More

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November 2018
6 Reads

[Technological innovations in dialysis].

Nephrol Ther 2018 Nov;14(6S):6S1-6S6

AURA, 12, rue Franquet, 75015 Paris, France. Electronic address:

The history of dialysis, which started only half a century ago, is rich in developments and technological innovations. Thanks to scientific progress and the development of knowledge in the field of dialysis, patient survival will continue to increase and quality of life will continue to improve. More precise purification, reductions in the size and weight of equipment as well as refinement of filtration membranes are a few of the recent and current breakthroughs, and are challenges for further development. Read More

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November 2018

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases.

Kidney Int 2018 Nov 21. Epub 2018 Nov 21.

Service de Néphrologie Transplantation Adultes, Hôpital Necker-Enfants Malades, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Paris, France; INSERM U1151, Institut Necker Enfants Malades, Hôpital Necker-Enfants Malades, Paris, France. Electronic address:

Mitochondrial diseases represent a significant clinical challenge. Substantial efforts have been devoted to identifying therapeutic strategies for mitochondrial disorders, but effective interventions have remained elusive. Recently, we reported attenuation of disease in a mouse model of the human mitochondrial disease Leigh syndrome through pharmacological inhibition of the mechanistic target of rapamycin (mTOR). Read More

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November 2018
2 Reads

Dialysis drains as a possible source for carbapenem-resistant pathogens causing an ICU outbreak.

Infection 2018 Nov 21. Epub 2018 Nov 21.

Klinik für Anästhesiologie and Intensivmedizin, Universität Duisburg-Essen and Universitätsklinikum Essen, Essen, Germany.

Objective Design: We describe a case series of patients colonized with KPC-producing Enterobacteriaceae related to dialysis drains at patient's bedside.

Setting: The study was set at the intensive care unit (ICU) of a tertiary referral hospital.

Patients: In March 2016, we discovered four ICU patients to be colonized with KPC-producing Enterobacteriaceae in routine screening. Read More

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November 2018
2 Reads

Tocilizumab treatment in refractory polyarteritis nodosa: a case report and review of the literature.

Rheumatol Int 2018 Nov 21. Epub 2018 Nov 21.

Asklepios Klinik Altona, Rheumatologie, Klinische Immunologie, Nephrologie, Paul-Ehrlich-Straße 1, 22763, Hamburg, Germany.

Polyarteritis nodosa (PAN) is a rare systemic vasculitis affecting multiple organs. Current standard treatment includes the use of glucocorticoids and cyclophosphamide. Unfortunately, some patients do not respond to this treatment and other therapeutic options are needed. Read More

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November 2018
6 Reads

Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis.

J Child Neurol 2018 Nov 21:883073818807787. Epub 2018 Nov 21.

1 Department of Neurology, University of California San Francisco, San Francisco, CA, USA.

Background:: Efferent visual dysfunction in children could lead to impaired quality of life at home and school. Eye-tracking can detect subtle efferent dysfunction missed on bedside examination but has not been validated in the pediatric multiple sclerosis population.

Objective:: We sought to determine the feasibility of eye-tracking in children and associations with multiple sclerosis. Read More

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November 2018
6 Reads

Impact of Assisted Peritoneal Dialysis Modality on Outcomes: A Cohort Study of the French Language Peritoneal Dialysis Registry.

Am J Nephrol 2018 21;48(6):425-433. Epub 2018 Nov 21.

Néphrologie, CHU Caen, Avenue de la Côte de Nacre, Caen,

Background: Patients on peritoneal dialysis (PD) can be assisted by a nurse or a family member and treated either by automated PD (APD) or continuous ambulatory PD (CAPD). The aim of this study was to evaluate the effect of PD modality and type of assistance on the risk of transfer to haemodialysis (HD) and on the peritonitis risk in assisted PD patients.

Method: This was a retrospective study based on data from the French Language PD Registry. Read More

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November 2018
1 Read

[Approach to the syndrome of inappropriate antidiuretic hormone secretion (SIADH)].

Rev Med Suisse 2018 Nov;14(628):2116-2120

Service de médecine interne, CHUV, 1011 Lausanne.

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is defined by euvolemic hyponatremia due to an inappropriate retention of free water under the effect of antidiuretic hormone. It is underdiagnosed despite well-defined criteria. Diagnosis involves a precise evaluation of volemia and the elimination of differential diagnoses. Read More

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November 2018
13 Reads

Minimal change nephrotic syndrome in patients infected with human immunodeficiency virus: a retrospective study of 8 cases.

BMC Nephrol 2018 Nov 20;19(1):331. Epub 2018 Nov 20.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et de Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000, Créteil, France.

Background: Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific features of this uncommon association remain to be determined.

Methods: We conduct a retrospective study. Read More

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November 2018
6 Reads

[Tuberculous bursitis of the shoulder in a patient with chronic renal insufficiency: about a case].

Pan Afr Med J 2018 27;30:182. Epub 2018 Jun 27.

Service de Chirurgie Orthopédique et Traumatologique, CHU Habib Bourguiba de Sfax,Tunisie.

Tuberculosis of the shoulder is rare. It encompasses all articular and periarticular tuberculouses of the shoulder. Its insidious evolution, mimicking inflammatory and degenerative diseases, reflects the frequency of its diagnostic delay. Read More

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December 2018
4 Reads

Biologika in der Therapie kindlicher chronisch-entzündlicher Darmerkrankungen.

Authors:
Philip Bufler

Drug Res (Stuttg) 2018 Nov 19;68(S 01):S15. Epub 2018 Nov 19.

Klinik für Pädiatrie m. S. Gastroenterologie, Nephrologie und Stoffwechselerkrankungen, Charité - Universitätsmedizin Berlin.

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November 2018

[New 2018 European guidelines for the management of hypertension and comparison with the 2017 American guidelines].

Rev Med Liege 2018 Nov;73(11):583-591

Service de Néphrologie-Dialyse-Hypertension et Transplantation, CHU de Liège, Belgique.

New European guidelines for high blood pressure management have just been published in 2018, modifying those published in 2013 and may be seen as a response to those published by the American societies late 2017. The latter proposed a new definition of hypertension (blood pressure equal or higher than 130/80 mmHg), a therapeutic approach based on the evaluation of the cardiovascular risk, and a blood pressure target inferior to130/80 mmHg in all patients, even those older than 80 years still valid. The European guidelines, on the contrary, maintain the definition threshold of hypertension to a blood pressure equal or higher than 140/90 mmHg. Read More

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November 2018
7 Reads

[CME Sonography 84: Scrotal Node Palpated].

Authors:
Jan Tuma

Praxis (Bern 1994) 2018 Nov;107(23):1249-1250

1 Ultrasound Learning Center (ULC) der European Federation of Ultrasound in Medicine and Biology (EFSUMB) am Institut für Allgemeine Innere Medizin und Nephrologie, Klinik Hirslanden, Zürich.

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November 2018

Rituximab and Fibrillary Glomerulonephritis: Interest of B Cell Reconstitution Monitoring.

J Clin Med 2018 Nov 9;7(11). Epub 2018 Nov 9.

AP-HP (Assistance Publique-Hôpitaux de Paris), Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare Syndrome Néphrotique Idiopathique, Hôpital Henri-Mondor/Albert-Chenevier, F-94000 Créteil, France.

Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by glomerular deposition of randomly arranged non-amyloid fibrils. FGN has a poor renal prognosis and its optimal treatment is a medical challenge. Rituximab therapy has recently emerged as a promising approach even though its mechanism of action remains hypothetical. Read More

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November 2018
4 Reads

[Metabolic acidosis in critical care : theoretical and practical aspects].

Rev Med Suisse 2018 Nov;14(626):2025-2029

Service de médecine intensive adulte, CHUV, 1011 Lausanne.

Acid-base disorders, and metabolic acidosis in particular, are frequently encountered in critical care typically in shock states, metabolic diseases decompensations or intoxications. Their systematic and careful evaluation frequently helps identifying underlying disease and guide clinical management. In most instances, therapy should focus on the underlying disease. Read More

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November 2018
4 Reads

Patients' wishes, pregnancy and vascular access: When one size does not fit all.

J Vasc Access 2018 Nov;19(6):518-520

4 Nephrology and Dialysis Unit, Ospedale San Carlo Borromeo, Department of Clinical and Biomedical Sciences 'Luigi Sacco', University of Milan, Milan, Italy.

Pregnancy in dialysis patients is a rare but important event that challenges our knowledge and demands re-thinking many aspects of our practice, including vascular access. This editorial briefly discusses some open questions on vascular access in this situation that challenge the motto 'fistula first' and underline the need for personalised approaches. Information on vascular access in pregnant women is scant. Read More

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November 2018
2 Reads

Maternal HLA-G*01:01:01:04 protects from anti-HLA-class II immunization in pregnant women.

Hum Immunol 2018 Nov 7. Epub 2018 Nov 7.

Aix Marseille Univ, CNRS, EFS, ADES, "Biologie des Groupes Sanguins", Marseille, France; Etablissement Français du Sang PACA Corse, Marseille, France. Electronic address:

Factors determining anti-HLA immunization are poorly understood, although anti-HLA immunization following pregnancy is well described. The HLA-G molecule has been extensively described for its implication in immunological tolerance, especially during pregnancy. Transplant studies show an association between HLA-G haplotypes and alloimmunization. Read More

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November 2018
4 Reads

Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies.

Cytokine 2019 Jan 7;113:446-452. Epub 2018 Nov 7.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Lyon, France; Inserm, U1111 Lyon, France; Ecole Normale Supérieure de Lyon, Lyon, France; Université Lyon 1, Lyon, France; CNRS, UMR5308, Lyon, France; Service d'Immunologie biologique, Hospices Civils de Lyon and Université Claude-Bernard Lyon 1, Lyon, France; Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l'enfant RAISE, Hôpital Femme Mère Enfant, Bron, France.

Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SLE). Yet, detection of type I IFN in these patients remains challenging as its amount is usually very low in patients' sera. Read More

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January 2019
7 Reads

Improving survival in end-stage renal disease: A case study.

Stat Methods Med Res 2018 Nov 9:962280218811357. Epub 2018 Nov 9.

1 Hospices Civils de Lyon, Pôle Santé Publique, Service de Biostatistique-Bioinformatique, Lyon, France.

Background: With the increase of life expectancy, *On behalf of the REIN registry. end-stage renal disease (ESRD) is affecting a growing number of people. Simultaneously, renal replacement therapies (RRTs) have considerably improved patient survival. Read More

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November 2018
6 Reads

[MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde (German version)].

Authors:
P Boor

Pathologe 2018 Nov 8. Epub 2018 Nov 8.

Institut für Pathologie, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.

Background: Macrophage migration-inhibitory factor (MIF) is a cytokine best known for its proinflammatory and disease-aggravating role in a number of conditions, including atherosclerosis, autoimmune diseases, sepsis, and glomerulonephritides.

Objectives: In our studies we aimed to define the role of MIF on local renal resident cells, in particular the renal epithelium.

Results: We have shown that MIF exerts local effects on glomerular cells, in particular the parietal epithelial cells and mesangial cells, promoting their pathological proliferation and aggravating disease course of a murine model of immune-mediated glomerulonephritis. Read More

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November 2018
3 Reads

sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction.

Mediators Inflamm 2018 8;2018:3952526. Epub 2018 Oct 8.

Département de Biochimie-Hormonologie, CHU Montpellier, Université de Montpellier, Montpellier, France.

Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Read More

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October 2018
6 Reads

[Life-threatening hypercalcemia and acute kidney injury induced by etanercept].

Nephrol Ther 2018 Nov 29;14(6):478-482. Epub 2018 Jun 29.

Service de néphrologie, université catholique de Louvain, cliniques universitaires Saint-Luc, 10, avenue Hippocrate, 1200 Bruxelles, Belgique. Electronic address:

Drug-induced sarcoidosis-like disease is a rare, but not exceptional, side effect of anti-tumor necrosis factor (anti-TNF) agents. The organs most commonly involved are lungs, skin and lymph nodes. Kidney involvement is exceptional. Read More

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November 2018
8 Reads

[Calcific uremic arteriolopathy in hemodialysis patient, review of literature through five cases reports].

Nephrol Ther 2018 Nov 29;14(6):439-445. Epub 2018 Jun 29.

Service de néphrologie-hémodialyse et transplantation rénale, université Cadi Ayyad, CHU Mohammed VI, BP 2360 Principal, avenue Ibn Sina, Marrakech, Maroc.

Calcific uremic arteriolopathy, also called calciphylaxis, is a rare and severe disorder that presents with skin ischemia and necrosis, sometimes it presents with systemic necrosis, the process is secondary to the obliteration of the arterioles first by sub-intimal calcium deposits and then by thrombosis. These lesions can often lead to death due to infectious complications and comorbidities such as diabetes, obesity, arteritis, diffuse vascular calcifications, heart disease and undernutrition. The diagnosis is suggested by the characteristic ischemic skin lesions and their distribution, often bilateral and painful, associeted with calcific uremic arteriolopathy risk factors (phosphocalcic abnormalities, anti-vitamin K). Read More

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November 2018
7 Reads

Pregnancy in Chronic Kidney Disease: Need for Higher Awareness. A Pragmatic Review Focused on What Could Be Improved in the Different CKD Stages and Phases.

J Clin Med 2018 Nov 5;7(11). Epub 2018 Nov 5.

Department of Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Pregnancy is possible in all phases of chronic kidney disease (CKD), but its management may be difficult and the outcomes are not the same as in the overall population. The prevalence of CKD in pregnancy is estimated at about 3%, as high as that of pre-eclampsia (PE), a better-acknowledged risk for adverse pregnancy outcomes. When CKD is known, pregnancy should be considered as high risk and followed accordingly; furthermore, since CKD is often asymptomatic, pregnant women should be screened for the presence of CKD, allowing better management of pregnancy, and timely treatment after pregnancy. Read More

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November 2018
19 Reads

23rd Nantes Actualités Transplantation: "Genomics and Immunogenetics of Kidney and Inflammatory Diseases - Lessons for Transplantation".

Transplantation 2018 Nov 5. Epub 2018 Nov 5.

Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes, Nantes, France.

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November 2018

Etanercept concentration and immunogenicity do not influence the response to Etanercept in patients with juvenile idiopathic arthritis.

Semin Arthritis Rheum 2018 Sep 17. Epub 2018 Sep 17.

Unité de Recherche Clinique Paris Descartes Necker Cochin, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Tarnier, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, EA 7323, Paris, France.

Objective: To investigate the relationship of clinical response of Juvenile Idiopathic Arthritis (JIA) to etanercept (ETN) with ETN levels, and the presence of anti-drug antibodies to ETN (ADAb).

Methods: Prospective study of JIA patients under 18 years old. Clinical and pharmacological data were collected at two visits. Read More

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September 2018
6 Reads

[Hyperthyroidism-induced calciphylaxis: A case report].

Nephrol Ther 2018 Dec 29;14(7):548-553. Epub 2018 Oct 29.

Service de néphrologie, groupe hospitalier La Pitié-Salpêtrière, 75013 Paris, France. Electronic address:

Background: Calciphylaxis or calcific uremic arteriolopathy (CUA) is a cutaneous disease with ulcerations secondary to calcification of cutaneous and subcutaneous small arteries and arterioles. It is a rare but severe disease with significant morbidity and mortality affecting 1 to 4% of dialysis patients. The circumstances of occurrence are multiple. Read More

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December 2018
4 Reads

Development and validation of a renal risk score in ANCA-associated glomerulonephritis.

Kidney Int 2018 Dec 29;94(6):1177-1188. Epub 2018 Oct 29.

Institut für Pathologie, Universitätsklinikum Hamburg Eppendorf, Hamburg, Germany.

Predicting renal outcome in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) remains a major challenge. We aimed to identify reliable predictors of end-stage renal disease (ESRD) and to develop and validate a clinicopathologic score to predict renal outcome in ANCA-associated GN. In a prospective training cohort of 115 patients, the percentage of normal glomeruli (without scarring, crescents, or necrosis within the tuft) was the strongest independent predictor of death-censored ESRD. Read More

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December 2018

2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC).

Blood Press 2018 12;27(6):314-340

ac CHU de Limoges , Limoges , France.

These practice guidelines on the management of arterial hypertension are a concise summary of the more extensive ones prepared by the Task Force jointly appointed by the European Society of Hypertension and the European Society of Cardiology. These guidelines have been prepared on the basis of the best available evidence on all issues deserving recommendations; their role must be educational and not prescriptive or coercive for the management of individual subjects who may differ widely in their personal, medical and cultural characteristics. The members of the Task Force have participated independently in the preparation of these guidelines, drawing on their academic and clinical experience and by objective examination and interpretation of all available literature. Read More

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December 2018
10 Reads

[CME Sonography 83/Answers: Incidental Finding].

Praxis (Bern 1994) 2018;107(22):1231-1234

1 Ultrasound Learning Center (ULC) der European Federation of Ultrasound in Medicine and Biology (EFSUMB) am Institut für Allgemeine Innere Medizin und Nephrologie, Klinik Hirslanden, Zürich.

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January 2018

B cell depletion therapy dampens CD8+ T cell response in ANCA-associated vasculitis.

Arthritis Rheumatol 2018 Oct 30. Epub 2018 Oct 30.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

Objective: To compare the effects of rituximab (RTX) and conventional immunosuppressants (CIS) on CD4 , regulatory (Treg) and CD8 T cells in ANCA-associated vasculitis (AAV).

Methods: Thorough immunophenotypic analysis of CD4 , Treg and CD8 cells of 51 AAV patients. Cytokine/chemokine production of in vitro stimulated CD8 T cells was assessed using a multiplex immunoassay. Read More

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October 2018
2 Reads

The Impact of Invariant NKT Cells in Sterile Inflammation: The Possible Contribution of the Alarmin/Cytokine IL-33.

Front Immunol 2018 15;9:2308. Epub 2018 Oct 15.

INSERM U1082 - IRATI Group, Poitiers, France.

Although the contribution of iNKT cells to induction of sterile inflammation is now well-established, the nature of the endogenous compounds released early after cellular stress or damage that drive their activation and recruitment remains poorly understood. More precisely, iNKT cells have not been described as being reactive to endogenous non-protein damage-associated molecular-pattern molecules (DAMPs). A second subset of DAMPs, called alarmins, are tissue-derived nuclear proteins, constitutively expressed at high levels in epithelial barrier tissues and endothelial barriers. Read More

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October 2018
5 Reads

Long-term outcome of diarrhea-associated hemolytic uremic syndrome is poorly related to markers of kidney injury at 1-year follow-up in a population-based cohort.

Pediatr Nephrol 2018 Oct 27. Epub 2018 Oct 27.

Service de Pédiatrie, Centre de référence Maladies Rénales Rares du Sud-ouest (SoRare), CHU de Bordeaux, Bordeaux, France.

Background: Hemolytic uremic syndrome due to Shiga toxin-producing E. coli (STEC-HUS) is the main cause of acute kidney injury in young children. Most fully recover kidney function; however, some develop long-term sequelae. Read More

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October 2018
3 Reads

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.

Nat Commun 2018 10 26;9(1):4483. Epub 2018 Oct 26.

Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, INSERM, Université de Nantes, Nantes, 44093, France.

Targeting the expansion of pathogenic memory immune cells is a promising therapeutic strategy to prevent chronic autoimmune attacks. Here we investigate the therapeutic efficacy and mechanism of new anti-human IL-7Rα monoclonal antibodies (mAb) in non-human primates and show that, depending on the target epitope, a single injection of antagonistic anti-IL-7Rα mAbs induces a long-term control of skin inflammation despite repeated antigen challenges in presensitized monkeys. No modification in T cell numbers, phenotype, function or metabolism is observed in the peripheral blood or in response to polyclonal stimulation ex vivo. Read More

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October 2018
14 Reads