8,127 results match your criteria Nephrologie & therapeutique[Journal]


[Renal risks of NSAIDs in endurance sports].

Rev Med Suisse 2019 Feb;15(639):444-447

Faculté de médecine, Université de Genève, 1205 Genève 4.

Endurance athletes, either professional or amateur, are consuming non steroidal anti-inflammatory drugs (NSAIDs) during their training and races. The goal is to decrease pain or to prevent a potential pain. These athletes, especially, the amateurs, do not do not know the side effects and have no medical supervision. Read More

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February 2019

[The vascular access of hemodialysis patients - What should the primary care physician know about ?]

Rev Med Suisse 2019 Feb;15(639):439-443

Service de chirurgie thoracique, Département Cœur-Vaisseaux, CHUV, 1011 Lausanne.

The most frequent dialysis modality in Switzerland is hemodialysis. Patients need a proper vascular access for this modality. There are three types of vascular access for hemodialysis : arteriovenous fistula, arteriovenous graft and central venous catheters. Read More

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February 2019

[Hepatorenal syndrome : something new?]

Rev Med Suisse 2019 Feb;15(639):432-435

Service de néphrologie, HUG, 1211 Genève 14.

Hepatorenal syndrome is a serious and frequent complication in patients suffering from liver cirrhosis. Its most severe type is characterized by the rapid occurrence of a functional acute kidney injury. However it is mainly an exclusion diagnosis. Read More

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February 2019

[Prescribing intravenous fluids in hospitalized patients : from need to harm].

Rev Med Suisse 2019 Feb;15(639):427-431

Service de néphrologie et hypertension, Département de médecine interne, CHUV, 1011 Lausanne.

Prescribing intravenous fluids in a hospital setting is a task that each clinician has to endorse in an everyday practice. This task is universal to the point that it is often undervalued, or even neglected during clinical teaching. However, one shouldn't underestimate the risks related to excessive fluid administration, of which the clinician often doesn't know the exact composition. Read More

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February 2019

[Metformin-associated lactic acidosis : myth or reality ?]

Rev Med Suisse 2019 Feb;15(639):422-426

Service de néphrologie, HUG, 1211 Genève 14.

Metformin is the first line therapy for patients with diabete type 2. However, the molecule is known to be responsible for lactic acidosis through its inhibition of the mitochondrial respiratory chain complex, a pathology called MALA (metformin associated lactic acidosis). This complication has been widely discussed in the literature because its development is usually the result of a multifactorial and complex process. Read More

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February 2019

[The skin as « third kidney »].

Rev Med Suisse 2019 Feb;15(639):418-421

Service de néphrologie et d'hypertension, CHUV, 1011 Lausanne.

The skin is the largest human organ playing an important role in protection, thermoregulation and sensation. Recent studies suggest that a new function has to be added: the storage of sodium. There is increasing evidence that sodium can accumulate in the skin, which suggests that the skin contributes to the regulation of sodium balance in humans, and possibly to the control of extracellular volume and blood pressure homeostasis. Read More

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February 2019

Michel Burnier : une carrière dédiée à la néphrologie et l’hypertension.

Rev Med Suisse 2019 Feb;15(639):415-416

Service de néphrologie, CHUV, Lausanne.

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February 2019

Novel ELISA for thrombospondin type 1 domain-containing 7A autoantibodies in membranous nephropathy.

Kidney Int 2019 Mar;95(3):666-679

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 Valbonne Sophia Antipolis, France. Electronic address:

Autoantibodies against phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type 1 domain-containing 7A (THSD7A) are emerging as biomarkers to classify membranous nephropathy (MN) and to predict outcome or response to treatment. Anti-THSD7A autoantibodies are detected by Western blot and indirect immunofluorescence test (IIFT). Here, we developed a sensitive enzyme-linked immunosorbent assay (ELISA) optimized for quantitative detection of anti-THSD7A autoantibodies. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.024DOI Listing

Receptor for advanced glycation end products: a key molecule in the genesis of chronic kidney disease vascular calcification and a potential modulator of sodium phosphate co-transporter PIT-1 expression.

Nephrol Dial Transplant 2019 Feb 18. Epub 2019 Feb 18.

Université de Reims Champagne-Ardenne, CNRS UMR 7369 (Matrice Extracellulaire et Dynamique Cellulaire, MEDyC), Reims, France.

Background: Chronic kidney disease (CKD) is associated with increased cardiovascular mortality, frequent vascular calcification (VC) and accumulation of uraemic toxins. Advanced glycation end products and S100 proteins interact with the receptor for advanced glycation end products (RAGE). In the present work, we aimed to investigate the role(s) of RAGE in the CKD-VC process. Read More

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http://dx.doi.org/10.1093/ndt/gfz012DOI Listing
February 2019

Urinary proteome signature of Renal Cysts and Diabetes syndrome in children.

Sci Rep 2019 Feb 18;9(1):2225. Epub 2019 Feb 18.

Mosaiques Diagnostics GmbH, Hannover, Germany.

Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia and genital tract malformations. In the present study, using capillary electrophoresis coupled to mass spectrometry (CE-MS), we investigated the urinary proteome of a pediatric cohort of RCAD patients and different controls to identify peptide biomarkers and obtain further insights into the pathophysiology of this disorder. Read More

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http://dx.doi.org/10.1038/s41598-019-38713-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379363PMC
February 2019

Challenges and opportunities for nephrology in Western Europe.

Kidney Int 2019 Feb 16. Epub 2019 Feb 16.

Oxford Kidney Unit and Transplant Centre, Churchill Hospital, Oxford, UK.

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http://dx.doi.org/10.1016/j.kint.2018.09.028DOI Listing
February 2019

Treatment and long-term outcome in primary distal renal tubular acidosis.

Nephrol Dial Transplant 2019 Feb 18. Epub 2019 Feb 18.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome.

Methods: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. Read More

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http://dx.doi.org/10.1093/ndt/gfy409DOI Listing
February 2019
1 Read
3.577 Impact Factor

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 02 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019
1 Read

Predicting the dose of vancomycin in ICU patients receiving different types of RRT therapy: a model-based meta-analytic approach.

Br J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Unité de Recherche Clinique, Innovation, Pharmacologie, Hôpital Nord, CHU de Saint-Etienne, F-42055, Saint-Etienne, France.

Aim: Previous pharmacokinetic (PK) studies have proposed various dosing regimens for vancomycin in intensive care unit (ICU) patients undergoing renal replacement therapy (RRT), but all are restricted to specific RRT modalities. To be useful in practice, a population PK model would need to predict vancomycin clearance during any RRT modality. Development of such a model is feasible using meta-analysis of published summarised estimates of vancomycin PK parameters. Read More

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http://dx.doi.org/10.1111/bcp.13904DOI Listing
February 2019

Impact on renal resistive index of diabetes in renal transplant donors and recipients: A retrospective analysis of 1827 kidney transplant recipients.

J Clin Hypertens (Greenwich) 2019 Feb 14. Epub 2019 Feb 14.

Néphrologie-Immunologie Clinique, Hôpital Bretonneau, CHRU Tours, Tours, France.

High renal resistive index (RI) is observed in diabetes and is associated with poor patient survival, but whether it is primarily due to renal vascular resistance or systemic vascular alterations is unclear. The respective impact of kidney transplant from diabetic donors or to diabetic recipients on RI would shed some light on this issue. The objective of the study was to analyze the impact of donor and recipient diabetes on RI in order to understand the respective impact of the kidney and the vascular environment. Read More

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http://dx.doi.org/10.1111/jch.13492DOI Listing
February 2019

[What future for renal transplantation facing the challenges of the 2021 transplant program?]

Nephrol Ther 2019 Feb 11. Epub 2019 Feb 11.

Service de néphrologie et transplantation rénale, CHU de Nantes, 44093 Nantes cedex 01, France.

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http://dx.doi.org/10.1016/j.nephro.2019.01.002DOI Listing
February 2019

Fluconazole as a New Therapeutic Tool to Manage Patients With NPTIIc (SLC34A3) Mutation: A Case Report.

Am J Kidney Dis 2019 Feb 11. Epub 2019 Feb 11.

Centre de Référence des Maladies Rénales Rares, filière ORKID, Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques; Centre de Référence des Maladies Rares du Calcium et du Phosphate, filière OSCAR; Faculté de Médecine Lyon Est, Université Lyon 1, Lyon; INSERM 1033, Prévention des Maladies Osseuses, Lyon, France. Electronic address:

Mutations in the SLC34A3 gene, encoding the sodium/phosphate cotransporter 2C (NPTIIc), induce decreased renal phosphate reabsorption, hypophosphatemia, decreased fibroblast growth factor 23 and parathyroid hormone, and increased 1,25-dihydroxyvitamin D (1,25[OH]D) levels. The complete phenotype is characterized by hypophosphatemia, hypercalciuria, and nephrolithiasis/nephrocalcinosis, leading to chronic kidney disease and osteoporosis in adults. We report a 15-year-old boy referred for nephrocalcinosis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.026DOI Listing
February 2019
1 Read

[Vitamin D deficiency and rickets : screening and treatment, practical aspects for clinicians].

Rev Med Suisse 2019 Feb;15(638):384-389

Unité romande de néphrologie pédiatrique, Hôpital des enfants, 1211 Genève 4.

Vitamin D deficiency is increasing in Switzerland. If cases of rickets are scarce, pediatricians are often dealing with patients presenting vitamin D deficiency. The increase in vitamin D deficiency is certainly due to modification of life habits in recent decades. Read More

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February 2019

[Fever and renal failure in a 38-year-old woman].

Med Klin Intensivmed Notfmed 2019 Feb 11. Epub 2019 Feb 11.

Klinik für Nephrologie, Angiologie, Hypertensiologie und Rheumatologie, KRH Klinikum Siloah, Stadionbrücke 4, 30459, Hannover, Deutschland.

Persistent fever and sepsis require a thorough anamnesis and examination especially in women of childbearing age to determine the presence of implanted devices. We report on a case of a severe septic shock with renal failure in a 38-year-old woman triggered by an infected intrauterine device (IUD). After a symptom-free period of 4 weeks after implantation of the pessary, acute and rapidly progressive nonspecific general symptoms and fever occurred. Read More

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http://dx.doi.org/10.1007/s00063-019-0546-yDOI Listing
February 2019
1 Read

[Lupus nephritis].

Nephrol Ther 2019 Feb 7. Epub 2019 Feb 7.

Service de néphrologie, hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris cedex 18, France; Université Paris Diderot, 5, rue Thomas-Mann, 75013 Paris, France; Inserm U1149, Département hospitalo-universitaire (DHU) Fibrosis-Inflammation-Remodeling (FIRE), 16, rue Henri Huchard, 75890 Paris cedex 18, France. Electronic address:

Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183065
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http://dx.doi.org/10.1016/j.nephro.2018.11.003DOI Listing
February 2019
3 Reads

Abnormal T-cell phenotype in episodic angioedema with hypereosinophilia (Gleich's syndrome): frequency, clinical implication and prognosis.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Service de Médecine Interne, Université Versailles Saint-Quentin-en-Yvelines, Centre de Référence des Syndromes Hyperéosinophiliques (CEREO), Hôpital Foch, Suresnes, France.

Background: Episodic Angioedema with eosinophilia (EAE, Gleich's syndrome) is a rare disorder consisting of recurrent episodes of angioedema, hypereosinophilia and frequent elevated serum Immunoglobin M.

Methods: We conducted a retrospective multicenter nationwide study regarding the clinical spectrum and therapeutic management of patients with EAE in France.

Results: Thirty patients were included with a median age at diagnosis of 41 years [5-84]. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.001DOI Listing
February 2019
3 Reads

[Mimics in rheumatology : Possibilities for mistakes and differential diagnoses].

Authors:
I Kötter

Z Rheumatol 2019 Feb;78(1):4-5

Rheumatologie, Klinische Immunologie, Nephrologie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

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http://dx.doi.org/10.1007/s00393-018-0579-2DOI Listing
February 2019

[Metabolic acidosis : Diagnosis and treatment].

Med Klin Intensivmed Notfmed 2019 Feb 6. Epub 2019 Feb 6.

Klinik für Nieren‑, Hochdruck- und Autoimmunerkrankungen, Alb Fils Kliniken, Göppingen, Deutschland.

Acid-base disorders and in particular metabolic acidosis are very common in critically ill patients and contribute significantly to morbidity and mortality. We shed light on the most common causes, the pathophysiology and treatments. Particular attention will be paid to the common practice of substituting sodium bicarbonate in the light of recent study results. Read More

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http://dx.doi.org/10.1007/s00063-019-0538-yDOI Listing
February 2019
1 Read

Conversion from calcineurin inhibitors to belatacept in HLA- sensitized kidney-transplant recipients with low-level donor specific antibodies.

Transplantation 2019 Jan 30. Epub 2019 Jan 30.

Service de Néphrologie -Transplantation rénale Adulte, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes Sorbonne Paris Cité Paris, France.

Background: Belatacept could be the treatment of choice in renal-transplant recipients with renal dysfunction attributed to CNI nephrotoxicity. Few studies have described its use in patients with DSA.

Methods: We retrospectively evaluated conversion from CNIs to belatacept in 29 HLA-immunized RTRs. Read More

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http://dx.doi.org/10.1097/TP.0000000000002592DOI Listing
January 2019
1 Read

[Rare erosive arthritis and dermatitis syndrome in Whipple's disease].

Z Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

Rheumatologie, Immunologie, Nephrologie, AK Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Whipple's disease is a rare infectious disease, which can affect various organ systems. Arthritis is a common symptom and therefore the infection is often misdiagnosed as seronegative rheumatoid arthritis. In rare cases an infection with Tropheryma whipplei can also cause skin lesions, such as subcutaneous nodules, erythema nodosum or vasculitis. Read More

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http://dx.doi.org/10.1007/s00393-019-0602-2DOI Listing
February 2019
3 Reads

Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children.

Pediatr Nephrol 2019 Feb 4. Epub 2019 Feb 4.

Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Background: Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy across subgroups of GFR, age, body mass index (BMI) and gender uncertain. To overcome this, a large cohort of children referred for GFR determination has been established from several European medical centres.

Methods: Three thousand four hundred eight measurements of GFR (mGFR) using plasma clearance of exogenous substances were performed in 2218 children aged 2-17 years. Read More

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http://dx.doi.org/10.1007/s00467-018-4185-yDOI Listing
February 2019
1 Read

[Lyme nephritis in humans: Physio-pathological bases and spectrum of kidney lesions].

Nephrol Ther 2019 Jan 31. Epub 2019 Jan 31.

Service de néphrologie-dialyse, centre hospitalier de Cahors, 335, rue du président-Wilson, 46000 Cahors, France; Département de néphrologie et transplantation d'organes, CHU Rangueil, 1, avenue du Professeur-Jean-Poulhès, 31400 Toulouse, France; Inserm U563, IFR-BMT, CHU Purpan, 105, avenue de Cassalardit, 31300 Toulouse, France; Université Paul Sabatier, route de Narbonne, 31330 Toulouse, France.

Known in less than half a century, borreliosis, or Lyme disease, is a zoonosis caused by the tick bite. It is the most common vector disease in Europe and the United States. Borrelia burgdorferi sensu lato, the bacterium in question, is fitted with a "cunning device" that allows it to trick the immune system and implant the infection chronically. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255183065
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http://dx.doi.org/10.1016/j.nephro.2018.09.004DOI Listing
January 2019
3 Reads

Persistent FDG/PET CT uptake in idiopathic retroperitoneal fibrosis helps identifying patients at a higher risk for relapse.

Eur J Intern Med 2019 Jan 31. Epub 2019 Jan 31.

Département de Médecine Interne, Hôpital Bichat, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Université Paris Diderot, Paris, France; Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France; INSERM U1149, Paris, France. Electronic address:

Background: The aim of this study was to evaluate the prognostic value of persistent retroperitoneal fibrosis FDG uptake using FDG/PET CT in patients with idiopathic retroperitoneal fibrosis (IRF).

Methods: In this monocentric retrospective cohort study, all patients admitted for IRF from January 2009 to December 2017 underwent a FDG/PET CT at diagnosis and during follow up. Metabolic activity of IRF was assessed by retroperitoneal fibrosis FDG uptake measured as maximal standardized uptake value (SUVmax). Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.019DOI Listing
January 2019
1 Read

Costimulatory blockade molecules and B-cell-mediated immune response: current knowledge and perspectives.

Kidney Int 2019 Jan 31. Epub 2019 Jan 31.

Service de Néphrologie et Transplantation, Pôle Cancérologie-Immunité-Transplantation-Infectiologie, Paris-Est Creteil, France; Institut National de la Santé et de la Recherch Médicale, U955, Equipe 21 and Université Paris-Est, Créteil, France. Electronic address:

There is an urgent need for therapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor-specific human leukocyte antigen antibodies and patients who develop de novo donor-specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In the last decade, both experimental and clinical studies highlighted the major impact of costimulation molecules in the control of immune responses both in the field of transplantation and autoimmune disease. Read More

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http://dx.doi.org/10.1016/j.kint.2018.10.028DOI Listing
January 2019

[Renal, vascular and urological variations and abnormalities in living kidney donor candidates].

Prog Urol 2019 Jan 28. Epub 2019 Jan 28.

Centre de transplantation d'organes, CHUV, rue du Bugnon 46, 1011 Lausanne, Suisse.

Introduction: The aim of this study was to determine the prevalence of anatomic variations (renal, vascular and urological) and acquired renal pathologies in living kidney donor candidates (LKDC).

Methods: This is a retrospective study of all LKDC referred to our center between April 2003 and September 2014. Of the 491 LKDC, 189 were initially excluded for medical reasons (n=140) or others reasons (n=49), without undergoing a radiological assessment. Read More

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http://dx.doi.org/10.1016/j.purol.2018.12.001DOI Listing
January 2019
1 Read

[Hyperkalemia - causes, diagnostic evaluation and treatment].

Authors:
Ralph Kettritz

Dtsch Med Wochenschr 2019 Feb 31;144(3):180-184. Epub 2019 Jan 31.

Nephrologie und Internistische Intensivmedizin, Charité-Universitätsmedizin Berlin und Experimental and Clinical Research Center a joint cooperation between the Charité Medical Faculty and the Max-Delbrück Center for Molecular Medicine Berlin-Buch.

Potassium is pivotal for membrane potentials and controls the functioning of a variety of organs, including nerves and muscles. The vast majority of potassium resides within cells. Disorders that compromise potassium influx into cells and decrease renal elimination cause hyperkalemia. Read More

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http://dx.doi.org/10.1055/a-0641-9552DOI Listing
February 2019
1 Read

[Muscular polyarteritis nodosa-a case-based review].

Z Rheumatol 2019 Jan 29. Epub 2019 Jan 29.

Rheumatologie, Klinische Immunologie, Nephrologie, Asklepios Klinik Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Background: Myalgia is a common but unspecific set of symptoms that may be caused by orthopedic, neurological and internal medical conditions, often resulting in a diagnostic challenge. Muscular polyarteritis nodosa (PAN) is a rare differential diagnosis of myalgia with elevated serological inflammatory markers.

Objective: Based on three clinical cases and the literature this review describes the essential clinical and diagnostic features of muscular PAN. Read More

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http://dx.doi.org/10.1007/s00393-019-0595-xDOI Listing
January 2019
1 Read

C3 glomerulopathy - understanding a rare complement-driven renal disease.

Nat Rev Nephrol 2019 Mar;15(3):129-143

Molecular Otolaryngology and Renal Research Laboratories and the Departments of Internal Medicine and Pediatrics (Divisions of Nephrology), Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy - dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) - have overlapping clinical and pathological features suggestive of a disease continuum. Dysregulation of the complement alternative pathway is fundamental to the manifestations of C3 glomerulopathy, although terminal pathway dysregulation is also common. Read More

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http://www.nature.com/articles/s41581-018-0107-2
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http://dx.doi.org/10.1038/s41581-018-0107-2DOI Listing
March 2019
11 Reads
8.542 Impact Factor

Choosing end-stage kidney disease treatment with elderly patients: are data available?

Nephrol Dial Transplant 2019 Jan 24. Epub 2019 Jan 24.

Universite Lyon, UCBL, INSERM CarMeN, CENS, Service de Néphrologie-Nutrition-Dialyse, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.

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http://dx.doi.org/10.1093/ndt/gfy404DOI Listing
January 2019

[Antithrombotic treatment in acute coronary syndrome and atrial fibrillation].

Herz 2019 Feb;44(1):29-34

Gerinnungspraxis im Cardio Centrum Mainz, Mainz, Deutschland.

The number of patients with atrial fibrillation (AF) is increasing due to the aging of the population. In addition, the number of patients with AF and indications for oral anticoagulation (OAC) for the prevention of stroke, who need dual antiplatelet treatment (DAPT) with acetylsalicylic acid (ASA) plus a PY inhibitor because of an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) is also increasing. In the past these patients received a triple therapy (TT) for 3-12 months. Read More

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http://dx.doi.org/10.1007/s00059-019-4781-zDOI Listing
February 2019

Low incidence of acute rejection within 6 months of kidney transplantation in HIV-infected recipients treated with raltegravir: the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE trial.

HIV Med 2019 Mar 27;20(3):202-213. Epub 2019 Jan 27.

Nephrology and Kidney Transplantation Department, Assistance Publique-Hôpitaux de Paris, Institut Francilien de Recherche en Néphrologie et Transplantation, Groupe Hospitalier Henri-Mondor/Albert-Chenevier, Créteil, France.

Objectives: High rates of clinical acute rejection after kidney transplantation have been reported in people living with HIV (PLHIV), probably as a consequence of drug interactions. We therefore investigated the incidence of acute rejection within 6 months of transplantation in HIV-infected recipients treated with a protease-inhibitor-free raltegravir-based regimen.

Methods: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS) 153 TREVE (NCT01453192) study was a prospective multicentre single-arm trial in adult PLHIV awaiting kidney transplantation, with viral load < 50 HIV-1 RNA copies/mL, CD4 T-cell count > 200 cells/μL, and HIV-1 strains sensitive to raltegravir, aiming to demonstrate 6-month clinical acute rejection rates < 30%. Read More

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http://dx.doi.org/10.1111/hiv.12700DOI Listing
March 2019
2 Reads

Myostatin and Insulin-Like Growth Factor 1 Are Biomarkers of Muscle Strength, Muscle Mass, and Mortality in Patients on Hemodialysis.

J Ren Nutr 2019 Jan 25. Epub 2019 Jan 25.

Department of Clinical Chemistry, University of Liège (ULg CHU), Liège, Belgium.

Objective: Muscle strength is frequently altered in hemodialysis patients. In the present work, five potential muscle biomarkers have been studied in their ability to assess muscular strength, muscular mass and to predict mortality of hemodialysis patients: activin-A, procollagen III N-terminal peptide, follistatin, myostatin and insulin-like growth factor-1 (IGF-1).

Design And Methods: Three independent cohorts of prevalent hemodialysis patients (2 from Liège, Belgium and 1 from Marseille, France) were considered in this observational prospective study. Read More

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http://dx.doi.org/10.1053/j.jrn.2018.11.010DOI Listing
January 2019
1 Read

Severe Chronic Kidney Disease Is Associated with a Lower Efficiency of Bariatric Surgery.

Obes Surg 2019 Jan 26. Epub 2019 Jan 26.

Service d'Endocrinologie, Diabétologie et Nutrition, Hôpital Bichat-Claude Bernard, HUPNVS, AP-HP, 46 Rue Henri Huchard, 75018, Paris, France.

Background: Obesity is a risk factor for chronic kidney disease (CKD) and a relative contraindication for renal transplantation. Bariatric surgery (BS) is an option to address this issue but we hypothesize that severe CKD is associated with a loss of efficacy of BS which could justify recommending it at an earlier stage of the CKD.

Methods: A retrospective study (n = 101 patients) to test primarily for differences in weight loss at 6 and 12 months according to estimated glomerular filtration rate categories (eGFR < 30 including patients on dialysis, 30-60, 60-90, and ≥ 90 ml/min/1. Read More

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http://dx.doi.org/10.1007/s11695-019-03703-zDOI Listing
January 2019
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Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs.

iScience 2019 Feb 11;12:168-181. Epub 2019 Jan 11.

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, ImNeuenheimer Feld 364, 69120 Heidelberg, Germany. Electronic address:

Pioneering human induced pluripotent stem cell (iPSC)-based pre-clinical studies have raised safety concerns and pinpointed the need for safer and more efficient approaches to generate and maintain patient-specific iPSCs. One approach is searching for compounds that influence pluripotent stem cell reprogramming using functional screens of known drugs. Our high-throughput screening of drug-like hits showed that imidazopyridines-analogs of zolpidem, a sedative-hypnotic drug-are able to improve reprogramming efficiency and facilitate reprogramming of resistant human primary fibroblasts. Read More

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http://dx.doi.org/10.1016/j.isci.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354736PMC
February 2019
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Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?

Clin Biochem 2019 Jan 25. Epub 2019 Jan 25.

Sorbonne Université, UPMC Université Paris 06, INSERM UMRS_1155, Paris, France.; AP-HP, Service de Néphrologie et Dialyse, Hôpital Tenon, Paris, France.

The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.01.006DOI Listing
January 2019
4 Reads

[Erratum to: CEUS-diagnosis of solid renal tumors].

Radiologe 2019 Feb;59(2):154

Institut für Radiologie, Krankenhaus Landshut-Achdorf, Landshut, Deutschland.

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http://dx.doi.org/10.1007/s00117-019-0494-9DOI Listing
February 2019
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[Isolated diastolic hypotension in hemodialysis: Risk factor for novel cardiovascular complications and all-cause mortality].

Ann Cardiol Angeiol (Paris) 2019 Jan 22. Epub 2019 Jan 22.

Service de néphrologie, dialyse et transplantation rénale, hôpital militaire d'instruction Mohammed V, Rabat, Maroc.

Intra dialytic hypotension is the most common complication in hemodialysis. However, isolated diastolic hypotension (IDH) in hemodialysis is asymptomatic and its detection requires repeated monitoring of blood pressure during dialysis sessions. To study this phenomenon, we conducted a prospective study over a period of 5 years in 45 chronic hemodialysis patients. Read More

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http://dx.doi.org/10.1016/j.ancard.2018.09.010DOI Listing
January 2019
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[An unusual cause of kidney disease in a diabetic patient].

Rev Med Liege 2019 Jan;74(1):15-19

Service de Néphrologie, CHU Sart Tilman, Liège, Belgique.

Diabetic nephropathy is a complication of diabetes that affects 25-40 % of diabetic patients. This complication is usually associated with other microangiopathic disorders. We describe a case of a patient suffering from type 2 diabetes with proteinuria, and no signs of retinopathy. Read More

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January 2019
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Belatacept in kidney transplantation and its limitations.

Expert Rev Clin Immunol 2019 Jan 24:1-9. Epub 2019 Jan 24.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation Rénale, CHU Grenoble-Alpes , Grenoble , France.

Introduction: Since the approval of belatacept in 2011 for use in the setting of de novo kidney transplantation, this CD80/86 - CD28 co-stimulation blocker has been shown to be a valuable treatment option for maintenance immunosuppression. Areas covered: In this setting, belatacept has been associated with superior glomerular filtration rate as compared to calcineurin inhibitor-based treatments because of the absence of nephrotoxicity. Additionally, belatacept avoids the cardiovascular side effects (e. Read More

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http://dx.doi.org/10.1080/1744666X.2019.1574570DOI Listing
January 2019
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Cytotoxic CD8 T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons.

Proc Natl Acad Sci U S A 2019 Feb 23;116(6):2312-2317. Epub 2019 Jan 23.

The Neuroscience Institute of Montpellier, Inserm UMR1051, University of Montpellier, Saint Eloi Hospital, 34090 Montpellier, France;

Adaptive immune response is part of the dynamic changes that accompany motoneuron loss in amyotrophic lateral sclerosis (ALS). CD4 T cells that regulate a protective immunity during the neurodegenerative process have received the most attention. CD8 T cells are also observed in the spinal cord of patients and ALS mice although their contribution to the disease still remains elusive. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1815961116
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http://dx.doi.org/10.1073/pnas.1815961116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369778PMC
February 2019
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Cyclin G1 and TASCC regulate kidney epithelial cell G-M arrest and fibrotic maladaptive repair.

Sci Transl Med 2019 Jan;11(476)

Renal Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

Fibrosis contributes to the progression of chronic kidney disease (CKD). Severe acute kidney injury can lead to CKD through proximal tubular cell (PTC) cycle arrest in the G-M phase, with secretion of profibrotic factors. Here, we show that epithelial cells in the G-M phase form target of rapamycin (TOR)-autophagy spatial coupling compartments (TASCCs), which promote profibrotic secretion similar to the senescence-associated secretory phenotype. Read More

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http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.aa
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http://dx.doi.org/10.1126/scitranslmed.aav4754DOI Listing
January 2019
4 Reads
15.843 Impact Factor

[Appropriateness of complementary exams in the initial assessment of acute kidney injury].

Rev Med Suisse 2019 Jan;15(635):211-214

Service de néphrologie, Hôpital de la Tour, Avenue J.-D. Maillard 3, 1217 Meyrin.

Current protocols recommend an initial assessment of acute kidney injury often extensive, not very useful in the majority of cases. A review of the literature allowed us to propose a management algorithm limiting these investigations integrating a « less is more » approach. The cornerstone of this algorithm is the urinary dipstick, inexpensive and easy to perform, used as a screening test. Read More

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January 2019
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[Clinical management of patients with hemophilia A in nephrology: Diagnostic and therapeutic challenges illustrated by the cases of 2 patients].

Nephrol Ther 2019 Jan 16. Epub 2019 Jan 16.

Centre de néphrologie et transplantation rénale, hôpital de la conception, 147, boulevard Baille, Assistance publique-Hôpitaux de Marseille, 13005 Marseille, France; Center for cardiovascular and nutrition research (C2VN), Inra 1260, Inserm 1263, Aix-Marseille Université, Campus Timone, 13005 Marseille, France. Electronic address:

Hemophilia A is an X-linked genetic hemorrhagic disorder characterized by a factor VIII deficiency. The availability of secured substitution products has led to a dramatic improvement of life expectancy in hemophiliac patients. Nowadays, adult hemophiliac patients may develop Chronic Kidney Disease (CKD) resulting from age-related comorbidities (hypertension, obesity, diabetes). Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.002DOI Listing
January 2019
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Obesity phenotype and patient-reported outcomes in moderate and severe chronic kidney disease: a cross-sectional study from the CKD-REIN cohort study.

Qual Life Res 2019 Jan 18. Epub 2019 Jan 18.

INSERM, CHU Nancy, Université de Lorraine, CIC-1433, Epidémiologie clinique, 54000, Nancy, France.

Purpose: To evaluate the association between obesity phenotypes and health-related quality of life (HRQoL) in non-dialysis-dependent CKD patients.

Methods: Data from the national CKD-REIN cohort which included 3033 patients with stage 3-4 CKD were used. Patients were divided into three groups: non-obese (NO) patients (BMI < 30 kg/m), metabolically healthy obese (MHO) (BMI ≥ 30 kg/m and ≤ 1 criterion NCEP/ATP III), and metabolically unhealthy obese (MUO) (BMI ≥ 30 kg/m and ≥ 2 criteria NCEP/ATP III). Read More

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http://link.springer.com/10.1007/s11136-019-02110-2
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http://dx.doi.org/10.1007/s11136-019-02110-2DOI Listing
January 2019
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[Renal toxicity of lithium].

Authors:
Aude Servais

Nephrol Ther 2019 Jan 15. Epub 2019 Jan 15.

Service de néphrologie adulte, hôpital Necker, université Paris Descartes, 149, rue de Sèvres, 75015 Paris, France. Electronic address:

Besides its efficiency, lithium has a narrow therapeutic index and can result in considerable toxicity. Among the potential side effects, two types of renal toxicity are observed: a decreased renal concentrating ability and a chronic renal failure. Lithium-induced polyuria is frequent, estimated to affect up to 40% of patients, and develops usually early. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.11.001DOI Listing
January 2019
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