8,262 results match your criteria Nephrologie & therapeutique[Journal]


Basophil involvement in lupus nephritis: a basis for innovation in daily care.

Nephrol Dial Transplant 2018 Jul 25. Epub 2018 Jul 25.

Centre de Recherche sur l'Inflammation, INSERM UMR1149, CNRS ERL8252, Université Paris Diderot, Sorbonne Paris Cité, Faculté de Médecine site Bichat, Laboratoire d'Excellence Inflamex, DHU FIRE, Paris, France.

Lupus nephritis (LN) affects a large proportion of patients with systemic lupus erythematosus (SLE). LN can lead to end-stage renal disease depending on when it is diagnosed and on the adequacy of the treatment administered to the patient based on the class of LN. Determination of the class and activity of LN is only possible by histological analysis of kidney biopsies. Read More

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http://dx.doi.org/10.1093/ndt/gfy245DOI Listing
July 2018
1 Read

Inflammation - dysregulated inflammatory response and strategies for treatment.

Authors:
K Herold R Mrowka

Acta Physiol (Oxf) 2019 Apr 22:e13284. Epub 2019 Apr 22.

Klinik für Innere Medizin III, AG Experimentelle, Nephrologie, Universitätsklinikum Jena, Jena, Germany.

Inflammation is a natural protective response to microbial infections and tissue injury. It functions to eliminate harmful stimuli and to repair damaged tissue. The inflammatory response is initiated by different inducers of exogenous and endogenous origin. Read More

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http://dx.doi.org/10.1111/apha.13284DOI Listing

Pharmacokinetics and Pharmacodynamics of Once-daily Prolonged-release Tacrolimus in Liver Transplant Recipients.

Clin Ther 2019 Apr 16. Epub 2019 Apr 16.

Département de Pharmacocinétique et Pharmacochimie, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France; UMR8638 CNRS, UFR Pharmacie, Université Paris Descartes, PRES Sorbonne Paris Cité, Paris, France. Electronic address:

Purpose: Limited published data are available regarding the pharmacokinetic (PK) and pharmacodynamic (PD) variables of prolonged-release tacrolimus (PRT) after liver transplantations. The goal of this study was to compare the PK and PD profiles of PRT in early and stable liver transplant recipients by developing a population PK model of PRT and investigating the profile of calcineurin activity (CNA) in the peripheral blood mononuclear cells.

Methods: A conversion from BID immediate-release tacrolimus (IRT) to once-daily PRT based on a one-to-one daily dose was performed at day 7 (D7) and D90 posttransplantation in groups A (n = 12) and B (n = 12), respectively. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.03.006DOI Listing

[Acute kidney injury: from creatinine to KIM‑1?]

Internist (Berl) 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Nephrologie und Rheumatologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

In addition to the early detection of an acute kidney injury (AKI), several problems or questions have to be addressed. These include the identification of the etiology, the severity (functional or structural), the prognosis (recovery or transition to chronic renal failure), the course of the disease (dialysis or not), and the identification of specific treatment options for AKI. The following article provides an overview of established and new AKI biomarkers as well as an outlook on the potential of future biomarker-associated models of AKI. Read More

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http://link.springer.com/10.1007/s00108-019-0602-y
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http://dx.doi.org/10.1007/s00108-019-0602-yDOI Listing
April 2019
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Comparing health-related quality of life in chronic diseases: the importance of analyzing references.

Nat Rev Dis Primers 2019 Apr 18;5(1):28. Epub 2019 Apr 18.

Aix Marseille University, Institut National de la Santé Et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA), Centre de Recherche en Cardio-Vasculaire et Nutrition (C2VN), Marseille, France.

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http://dx.doi.org/10.1038/s41572-019-0082-3DOI Listing

[Laboratory tests for kidney disease].

Authors:
G M Fiedler B Vogt

Internist (Berl) 2019 Apr 17. Epub 2019 Apr 17.

Universitätsklinik für Nephrologie und Hypertonie, Inselspital, Universitätsspital Bern, Universität Bern, 3010, Bern, Schweiz.

Kidney diseases are among the most frequently reported diseases with a poor prognosis that are diagnosed too late. According to current Kidney Disease Improving Global Outcomes (KDIGO) guidelines, diagnosis and risk stratification are mainly based on functional markers (creatinine and cystatin C), which are used to determine the estimated glomerular filtration rate (eGFR) and the analysis of urinary albumin excretion as a marker of kidney damage. These methods have limitations that can complicate the interpretation of the results and can lead to a delay of the diagnosis as well as to a misinterpretation of the prognosis. Read More

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http://dx.doi.org/10.1007/s00108-019-0598-3DOI Listing
April 2019
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Néphropathie diabétique - Prise en charge multidisciplinaire du diabète : recommandations pour la pratique clinique.

Rev Med Suisse 2019 Apr;15(647):841

Unité d'évaluation des soins, Institut universitaire de médecine sociale et préventive, Biopôle 2, route de la Corniche 10, 1010 Lausanne.

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[Ascites and Renal Insufficiency in a 25 Year Old Woman].

Dtsch Med Wochenschr 2019 Apr 15;144(8):544-546. Epub 2019 Apr 15.

Abteilung für Tropenmedizin und Infektiologie und Sektion Nephrologie, Zentrum für Innere Medizin II, Universitätsmedizin Rostock.

Clinical Case:  We report of a 25 year old woman who presented with acute dysuria. She had a normal vaginal delivery three months earlier. She developed increasing ascites and laboratory findings were indicative for acute renal failure. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0819-6331
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http://dx.doi.org/10.1055/a-0819-6331DOI Listing
April 2019
3 Reads

[From what initial assessment of renal function seek advice from the nephrologist?]

Authors:
Maurice Laville

Rev Prat 2019 Mar;69(3):297-299

Service de néphrologie, centre hospitalier Lyon-Sud, université de Lyon, Inserm CarMeN U1060 Réseau TIRCEL Pierre-Bénite, France.

From what initial assessment of renal function seek advice from the nephrologist? The discovery of chronic kidney disease immediately raises the issue of care coordination between the primary care physician and the nephrologist. The role of the nephrologist is to establish the diagnosis of the primary renal disease, to set up its specific treatment, to evaluate renal and global risk, to propose a personalized care program, to provide therapeutic education, and to prepare the patient to replacement therapies in the presence of an advanced or rapidly evolving chronic kidney disease. Depending on the nature of the kidney disease, its stage, its complications, but also the availability of care resources, sharing tasks between caregivers shall adapt over time to fulfil the expectations of the informed patient. Read More

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March 2019
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Suggested guidelines for the diagnosis and management of urea cycle disorders: first revision.

J Inherit Metab Dis 2019 Apr 14. Epub 2019 Apr 14.

Division of Metabolism, Bambino Gesù Children's Hospital, Rome, Italy.

In 2012 we published guidelines summarizing and evaluating late 2011 evidence for diagnosis and therapy of urea cycle disorders (UCDs). With 1:35,000 estimated incidence, UCDs cause hyperammonemia of neonatal (~50%) or late onset that can lead to intellectual disability or death, even while effective therapies do exist. In the 7 years that have elapsed since the first guideline was published, abundant novel information has accumulated, experience on newborn screening for some UCDs has widened, a novel hyperammonemia-causing genetic disorder has been reported, glycerol phenylbutyrate has been introduced as a treatment, and novel promising therapeutic avenues (including gene therapy) have been opened. Read More

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http://dx.doi.org/10.1002/jimd.12100DOI Listing
April 2019
2 Reads

[F-FDG positron emission tomography in non-oncological renal pathology: Current indications and perspectives].

Nephrol Ther 2019 Apr 11. Epub 2019 Apr 11.

Service de néphrologie, centre hospitalier universitaire de Liège, avenue Hippocrate 13, 4000 Liège, Belgique; Groupe interdisciplinaire de géno-protéomique appliquée (GIGA), sciences cardiovasculaires, université de Liège, Liège, Belgique. Electronic address:

Positron emission tomography combined with computed tomography (PET/CT) is a nuclear imaging technique which provides anatomical and functional information. PET/CT is increasingly used in non-oncological nephrology since conventional radiological approaches after injection of contrast agents are relatively contra-indicated in patients with chronic kidney disease (CKD). PET/CT after i. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.11.007DOI Listing
April 2019
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Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors.

Kidney Int 2019 Mar 15. Epub 2019 Mar 15.

Centre de Recherche en Transplantation et Immunologie, UMR 1064, INSERM, Université de Nantes, Nantes, France; Institut de Transplantation Urologie Néphrologie, CHU Nantes, Nantes, France; Department of Nephrology and Immunology, Center Hospitalier Universitaire de Nantes, Nantes, France. Electronic address:

Secondary hemolytic uremic syndrome (HUS) is a heterogeneous group of thrombotic microangiopathies associated with various underlying conditions. Whether it belongs to the spectrum of complement-mediated HUS remains controversial. We analysed the presentation, outcome, and frequency of complement gene rare variants in a cohort of 110 patients with secondary HUS attributed to drugs (29%), autoimmune diseases (24%), infections (17%), malignancies (10%), glomerulopathies (9%), extra-renal organ transplantation (8%), and pancreatitis (3%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193016
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http://dx.doi.org/10.1016/j.kint.2019.01.023DOI Listing
March 2019
6 Reads

[Acetate-free bicarbonate dialysate: Which acid in the dialysis buffer?]

Nephrol Ther 2019 Apr;15 Suppl 1:S91-S97

Service de néphrologie/dialyse, hôpital de la Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'hôpital, 75013 Paris, France; Inserm CESP équipe 5, épidémiologie rénale et cardiovasculaire, 94800 Villejuif, France.

The mix of bicarbonate and divalent cations requires a small amount of acid to avoid insoluble precipitation in the dialysate buffer. Small doses of acetic acid (3-7mmol/L) are commonly used. Acetic acid may be replaced by hydrochloric acid or citric acid to achieve acetate-free haemodialysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193001
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http://dx.doi.org/10.1016/j.nephro.2019.02.003DOI Listing
April 2019
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Balancing the genetic risk of APOL1 kidney disease variants.

Nephrol Ther 2019 Apr;15 Suppl 1:S79-S84

Centre de Recherche en Transplantation et Immunologie (CRTI) UMR1064, Inserm, Université de Nantes, 30, boulevard Jean-Monnet, 44093 Nantes cedex 1, France; Institut de Transplantation en Urologie-Néphrologie (ITUN), CHU Nantes, 30, boulevard Jean-Monnet, 44093 Nantes cedex 1, France; École centrale de Nantes, 1, rue de la Noë, 44300 Nantes, France. Electronic address:

African-Americans exhibit an excess risk for chronic and end-stage kidney disease compared to the non-African populations. Two APOL1 genetic variants were shown to account for the majority of this racial disparity in glomerulopathies and other non-diabetic kidney disease. The high-risk genotype has only been reported in populations with recent African ancestry (14 % in African-Americans and up to more than 30 % in West Africa). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193004
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http://dx.doi.org/10.1016/j.nephro.2019.03.007DOI Listing
April 2019
2 Reads

[Non anti-HLA antibodies and acute rejection: A critical viewpoint].

Nephrol Ther 2019 Apr;15 Suppl 1:S53-S59

Service de néphrologie et transplantation rénale adulte, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France; Inserm, U1151, 149, rue de Sèvres, 75015 Paris, France.

In solid organ transplantation, the deleterious effect of antibodies directed against donor HLA antigens, whether preformed or de novo, is well established. Anti-HLA antibodies have been associated not only with the risk of antibody-mediated rejection but also with late graft dysfunction and are now considered to be the leading cause of allograft loss after renal transplantation. In addition to HLA antibodies, the possible involvement of non-HLA antibodies targeting donor endothelial cells has long been the subject of intense research. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193004
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http://dx.doi.org/10.1016/j.nephro.2019.03.003DOI Listing
April 2019
3 Reads

[Infectious complications after kidney transplantation].

Nephrol Ther 2019 Apr;15 Suppl 1:S37-S42

Service de néphrologie et transplantation adulte, hôpital Necker Enfants Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France.

Infectious complications are one of the leading causes of hospitalization and mortality in kidney transplant recipients. They are more frequent during the year following transplantation, and in the elderly. Community infections, such as pyelonephritis and pneumonia, are from far the most common infections. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.010DOI Listing
April 2019
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[In-hospital management of acute complicated urinary tract infections].

Nephrol Ther 2019 Apr;15 Suppl 1:S27-S32

Unité de bactériologie, groupe hospitalier Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil cedex, France; Université Paris-Est-Créteil-Val-de-Marne, avenue du Général-de-Gaulle, 94010 Créteil cedex, France.

Upper tract urinary tract infections that require hospitalization have been the focus of national recommendations in 2018 by the French society of infectious diseases (Spilf). We here propose to discuss several complex-challenging situations: severe infection with sepsis, pyelonephritis in the pregnant woman, management of infections involving multiresistant bacteria and infection in polycystic kidney disease. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.02.002DOI Listing
April 2019
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[Adult IgA vasculitis (Henoch-Schönlein purpura)].

Nephrol Ther 2019 Apr;15 Suppl 1:S13-S20

Service de néphrologie et de transplantation, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France; Inserm U1149, CRI, faculté de médecine Xavier-Bichat, 16, rue Henri-Huchard, 75018 Paris, France. Electronic address:

IgA vasculitis is a systemic vasculitis affecting small vessels. IgA vasculitis usually affect children whereas it is rare in adults (150 to 200 for 1) in which the disease is often more serious with more frequent and severe nephritis. Prevalence of adult IgA vasculitis is unknown and its annual incidence is 1 in 1 million. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193000
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http://dx.doi.org/10.1016/j.nephro.2019.02.001DOI Listing
April 2019
2 Reads

[Treatment of AL amyloidosis].

Nephrol Ther 2019 Apr;15 Suppl 1:S115-S121

Service de néphrologie et transplantation, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France; Centre de référence « Amylose AL et autres maladies par dépôt d'immunoglobulines monoclonales », 2, rue de la Milétrie, 86021 Poitiers, France.

AL amyloidosis is caused by the conversion of monoclonal immunoglobulin light chains into amyloid fibrillar aggregates that deposit in tissue and lead to organ dysfunction. Diagnosis is histological and relies primarily on non-invasive biopsies, showing Congo red-positive amorphous deposits containing immunoglobulin light chains, most commonly of lambda isotype. The clinical presentation is extremely polymorphous, due to the large number of organs that can be affected by the disease. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.002DOI Listing
April 2019
1 Read

[Dialysis monitor and low-cost haemodialysis].

Nephrol Ther 2019 Apr;15 Suppl 1:S109-S113

Association rein artificiel mutualisé Thận-Nhân-Tạo (RAM-TNT), Maison des associations, boîte n(o) 57, 11, rue Caillaux, 75013 Paris, France.

An experimental model of a hemodialysis monitor has been developed to perform ultrafiltration control, and urea and creatinine clearance tests. This model allowed us to develop an original device that separates the used dialysate from fresh dialysate and to define the characteristics of an industrial prototype which ultimate objective is to reduce the costs of haemodialysis treatment in low and middle-income countries. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.02.006DOI Listing

[Prescribing the dose of dialysis].

Nephrol Ther 2019 Apr;15 Suppl 1:S101-S107

Service de néphrologie hémodialyse, centre hospitalier universitaire de Rouen, 147, avenue du Maréchal-Juin, 76230 Rouen cedex, France.

The concept of dose of dialysis is relatively recent. It evaluates the adequacy of extrarenal clearance, in order to provide the best chances of survival to chronic dialysis patients. Although it presents drawbacks, urea Kt/V is recognized as the most clinically relevant indicator. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17697255193004
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http://dx.doi.org/10.1016/j.nephro.2019.03.001DOI Listing
April 2019
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[CGM-Continuous Glucose Monitoring-Statement of the Austrian Diabetes Association (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

This position statement represents the recommendations of the Austrian Diabetes Association regarding the clinical diagnostic and therapeutic application, safety and benefits of continuous subcutaneous glucose monitoring systems in patients with diabetes, based on current evidence. Read More

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http://link.springer.com/10.1007/s00508-019-1465-x
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http://dx.doi.org/10.1007/s00508-019-1465-xDOI Listing
April 2019
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[Nutrition for diabetic patients (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

Evidence demonstrates that medical diabetes treatment has to be accompanied by lifestyle modifications. Structured nutrition interventions and increased physical activity will help patients to normalise, respectively maintain their body weight.The main target of a medical nutrition therapy aims at achieving normal or nearly normal blood glucose levels, prevention of delay of diabetes associated complications. Read More

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http://link.springer.com/10.1007/s00508-019-1470-0
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http://dx.doi.org/10.1007/s00508-019-1470-0DOI Listing
April 2019
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[Position statement: surgery and diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung für Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

This position statement reflects the opinion of the Austrian Diabetes Association concerning the perioperative management of patients with diabetes mellitus based on the available scientific evidence. The paper covers necessary preoperative examinations from an internal/diabetological point of view as well as the perioperative metabolic control by means of oral antidiabetics and/or insulin therapy. Read More

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http://dx.doi.org/10.1007/s00508-019-1459-8DOI Listing

[Hospital diabetes management (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Diabetologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Auenbruggerplatz 15, 8036, Graz, Österreich.

This position statement presents the recommendations of the Austrian Diabetes Association for diabetes management of adult patients during inpatient stay. It is based on the current evidence with respect to blood glucose targets, insulin therapy and treatment with oral antidiabetic drugs during inpatient hospitalization. Additionally, special circumstances such as intravenous insulin therapy, concomitant therapy with glucocorticoids and use of diabetes technology during hospitalization are discussed. Read More

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http://link.springer.com/10.1007/s00508-019-1447-z
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http://dx.doi.org/10.1007/s00508-019-1447-zDOI Listing
April 2019
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[Diabetes education and counselling in adult patients with diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

1. Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

Diabetes education and self-management play a critical role in diabetes care. Patient empowerment aims to actively influence the course of the disease by self-monitoring and subsequent treatment modification as well as the ability of patients to integrate diabetes into their daily life and to appropriately adapt it to their life style situation. Diabetes education has to be made accessible for all persons with the disease. Read More

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http://dx.doi.org/10.1007/s00508-019-1449-xDOI Listing
April 2019
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[Migration and diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

5. Medizinische Abteilung mit Endokrinologie, Rheumatologie und Akutgeriatrie, Wilhelminenspital der Stadt Wien, Montlearstraße 37, 1160, Wien, Österreich.

The article deals with the demographic data of migration in Austria and with therapeutic advice concerning drug therapy and diabetes education for patients with migration background. In this context sociocultural specifics are discussed. These suggestions are seen complementary to the general treatment guidelines of the Austrian Diabetes Association. Read More

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http://link.springer.com/10.1007/s00508-019-1446-0
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http://dx.doi.org/10.1007/s00508-019-1446-0DOI Listing
April 2019
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["Diabesity"-Obesity and type 2 diabetes (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Medizinische Abteilung mit Diabetologie, Endokrinologie und Nephrologie, Krankenanstalt Rudolfstiftung, Wien, Österreich.

For several years obesity and type 2 diabetes have been increasingly summarized under the name "diabesity". This is due to the fact that in most cases obesity precedes diabetes and is the most important risk factor for the worldwide increase of type 2 diabetes. The body mass index (BMI) is a very crude measure of body fatness in individuals. Read More

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http://dx.doi.org/10.1007/s00508-018-1418-9DOI Listing
April 2019
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[Antihyperglycemic treatment guidelines for diabetes mellitus type 2 (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin und Gastroenterologie, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Österreich.

Hyperglycemia significantly contributes to complications in patients with diabetes mellitus. While lifestyle interventions remain cornerstones of disease prevention and treatment, most patients with type 2 diabetes will eventually require pharmacotherapy for glycemic control. The definition of individual targets regarding optimal therapeutic efficacy and safety as well as cardiovascular effects is of great importance. Read More

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http://dx.doi.org/10.1007/s00508-019-1471-zDOI Listing

[Insulin pump therapy in children, adolescents and adults, guidelines (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Abteilung für Innere Medizin, Privatklinik Wehrle-Diakonissen, Salzburg, Österreich.

This position statement is based on current evidence available on the safety and benefits of continuous subcutaneous insulin infusion therapy (CSII, pump therapy) in diabetes with an emphasis on the effects of CSII on glycemic control, hypoglycaemia rates, occurrence of ketoacidosis, quality of life and the use of insulin pump therapy in pregnancy. The current article represents the recommendations of the Austrian Diabetes Association for the clinical praxis of insulin pump treatment in children, adolescents and adults. Read More

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http://dx.doi.org/10.1007/s00508-019-1485-6DOI Listing
April 2019
1 Read

[Diagnosis and insulin therapy of type 1 diabetes mellitus (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

ICMR - Institute for Cardiovascular and Metabolic Research, Johannes Kepler Universität Linz, Linz, Österreich.

This guideline summarizes diagnosis of type 1 diabetes, including accompanying autoimmune disorders, insulin therapy regimens and glycemic target values. Read More

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http://dx.doi.org/10.1007/s00508-019-1493-6DOI Listing

[Diabetic kidney disease (Update 2019) : Position paper of the Austrian Diabetes Association and the Austrian Society for Nephrology].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Österreich.

Recent epidemiological investigations have shown that approximately 2-3% of all Austrians suffer from diabetes with renal involvement, i. e. 250,000 people in Austria are affected. Read More

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http://link.springer.com/10.1007/s00508-018-1425-x
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http://dx.doi.org/10.1007/s00508-018-1425-xDOI Listing
April 2019
4 Reads

[Individualising antihypertensive therapy in patients with diabetes. A guideline by the Austrian Diabetes Association (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

VIVIT Institut, Landeskrankenhaus Feldkirch, Feldkirch, Österreich.

Hypertension is one of the most important comorbidities of diabetes, contributing significantly to death and leads to macrovascular and microvascular complications. When assessing the medical priorities for patients with diabetes, treating hypertension should be a primary consideration. In the present review practical approaches to hypertension in diabetes, including individualized targets for preventing specific complications are discussed according to current studies and guidelines. Read More

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http://dx.doi.org/10.1007/s00508-019-1460-2DOI Listing

Vitamin D, bone alkaline phosphatase and parathyroid hormone in healthy subjects and haemodialysed patients from West Africa: impact of reference ranges and parathyroid hormone generation assays on the KDIGO guidelines.

Clin Kidney J 2019 Apr 5;12(2):288-293. Epub 2018 Sep 5.

Department of Nephrology, Dialysis and Transplantation, University of Liège, CHU de Liège, Liège, Belgium.

Background: The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend targets based on multiples of the upper limit of normal (ULN) of parathyroid hormone (PTH) concentration. However, the ULN has not always been correctly established by manufacturers. While it is known that the ULN is supposed to be higher in African Americans than in Caucasians, it is largely unknown in Africans. Read More

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https://academic.oup.com/ckj/article/12/2/288/5091022
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http://dx.doi.org/10.1093/ckj/sfy074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452202PMC
April 2019
3 Reads

Long-term outcome in inherited nephrogenic diabetes insipidus.

Clin Kidney J 2019 Apr 13;12(2):180-187. Epub 2018 Apr 13.

Department of Pediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Background: Inherited nephrogenic diabetes insipidus (NDI) is a rare disorder characterized by impaired urinary concentrating ability. Little clinical data on long-term outcome exists.

Method: This was a single-centre retrospective medical record review of patients with a diagnosis of NDI followed between 1985 and 2017. Read More

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https://academic.oup.com/ckj/article/12/2/180/4969891
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http://dx.doi.org/10.1093/ckj/sfy027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452213PMC
April 2019
3 Reads

Outcomes in patients with atypical hemolytic uremic syndrome treated with eculizumab in a long-term observational study.

BMC Nephrol 2019 Apr 10;20(1):125. Epub 2019 Apr 10.

Division of Pediatric Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, 2015 Uppergate Drive NE, Atlanta, GA, 30322, USA.

Background: There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of patients with aHUS treated with eculizumab.

Methods: Patients with aHUS who participated in any of five parent eculizumab trials and received at least one eculizumab infusion were eligible for enrollment in a long-term follow-up study. Read More

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http://dx.doi.org/10.1186/s12882-019-1314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456946PMC
April 2019
1 Read

Emerging Roles of Aryl Hydrocarbon Receptors in the Altered Clearance of Drugs during Chronic Kidney Disease.

Toxins (Basel) 2019 Apr 7;11(4). Epub 2019 Apr 7.

Aix Marseille Université, INSERM, C2VN, 13005 Marseille, France.

Chronic kidney disease (CKD) is a major public health problem, since 300,000,000 people in the world display a glomerular filtration rate (GFR) below 60 mL/min/1.73m². Patients with CKD have high rates of complications and comorbidities. Read More

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http://dx.doi.org/10.3390/toxins11040209DOI Listing

Schwere Candida-Balanoposthitis unter gleichzeitiger Therapie mit Secukinumab und dem Antidiabetikum Empagliflozin (Natrium-Glukose-Cotransporter 2 - SGLT2-Inhibitor).

J Dtsch Dermatol Ges 2019 04;17(4):456-458

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Halle (Saale).

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http://dx.doi.org/10.1111/ddg.13807_gDOI Listing

Epitope load identifies kidney transplant recipients at risk of allosensitization following minimization of immunosuppression.

Kidney Int 2019 Mar 5. Epub 2019 Mar 5.

Laboratoire d'Immunologie et Histocompatibilité Hôpital Saint-Louis, Paris, France; INSERM UMRs 1160, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France.

Human leukocyte antigen (HLA) mismatching and minimization of immunosuppression are two major risk factors for the development of de novo donor-specific antibodies, which are associated with reduced kidney graft survival. Antibodies do not recognize whole HLA antigens but rather individual epitopes, which are short sequences of amino acids in accessible positions. However, compatibility is still assessed by the simple count of mismatched HLA antigens. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193011
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http://dx.doi.org/10.1016/j.kint.2018.12.029DOI Listing
March 2019
4 Reads

Intra-patient viral evolution in polyomavirus-related diseases.

Philos Trans R Soc Lond B Biol Sci 2019 May;374(1773):20180301

1 Centre de Recherche en Transplantation et Immunologie UMR 1064, INSERM, Université de Nantes , 44093 Nantes cedex 01 , France.

Human polyomaviruses show relatively little genetic polymorphism between isolates, indicating that these viruses are genetically stable between hosts. However, it has become increasingly clear that intra-host molecular evolution is a feature of some polyomavirus (PyV) infections in humans. Mutations inducing premature stop codons in the early region of the integrated Merkel cell PyV genome lead to the expression of a truncated form of the large tumour (LT) antigen that is critical for the transformation of Merkel cell carcinoma (MCC) cells. Read More

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http://dx.doi.org/10.1098/rstb.2018.0301DOI Listing
May 2019
3 Reads

[Middle-molecule uremic toxins: A renewed interest].

Nephrol Ther 2019 Apr;15(2):82-90

Service de néphrologie-hémodialyse, hôpital Ambroise Paré, AP-HP, 9, avenue du Général de Gaulle, 92104 Boulogne-Billancourt, France; Équipe 5 CESP, UVSQ, Inserm U1018, Paris Saclay, 16, avenue Paul Vaillant-Couturier, 94800 Villejuif, France.

Cardiovascular mortality in patients with chronic kidney disease remains a major problem. The uremic toxins among which the molecules of middle molecular weight are counted contribute significantly to this high mortality, alongside the traditional risk factors. They generate and maintain a chronic inflammatory state called low-level chronic inflammatory state. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.09.003DOI Listing

Selective Costimulation Blockade With Antagonist Anti-CD28 Therapeutics in Transplantation.

Transplantation 2019 Apr 2. Epub 2019 Apr 2.

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France.

Nephrotoxicity of calcineurin inhibitors and uncontrolled effector function of alloreactive T lymphocytes are main drivers of transplant dysfunctions. T lymphocytes either directly damage tissues or indirectly promote inflammation and antibody responses. Beside inhibitors of calcium-dependent pathways and anti-metabolites, modulators of T cell co-stimulation are elected pharmacological tools to enable interference with immune-mediated transplant dysfunctions. Read More

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http://dx.doi.org/10.1097/TP.0000000000002740DOI Listing
April 2019
1 Read

Growth Patterns After Kidney Transplantation in European Children Over the Past 25 Years: An ESPN/ERA-EDTA Registry Study.

Transplantation 2019 Apr 1. Epub 2019 Apr 1.

Pediatric Nephrology Unit, Bordeaux University Hospital, Bordeaux, France.

Background: Improved management of growth impairment might have resulted in less growth retardation after pediatric kidney transplantation (KT) over time. We aimed to analyze recent longitudinal growth data after KT in comparison to previous eras, its determinants, and the association with transplant outcome in a large cohort of transplanted children using data from the ESPN/ERA-EDTA Registry.

Methods: A total of 3,492 patients transplanted before 18 years from 1990-2012 were included. Read More

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http://dx.doi.org/10.1097/TP.0000000000002726DOI Listing
April 2019
2 Reads

[CME: Nephrotic Syndrome in Adults: Presentation, Diagnosis, Therapy].

Praxis (Bern 1994) 2019 ;108(5):347-355

1 Klinik für Innere Medizin, Stadtspital Triemli Zürich.

CME: Nephrotic Syndrome in Adults: Presentation, Diagnosis, Therapy Abstract. The nephrotic syndrome is defined by renal protein loss with hypalbuminaemia and edema. Hyperlipoproteinemia and thrombophilia are not diagnostic criteria, but are frequently associated conditions. Read More

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http://dx.doi.org/10.1024/1661-8157/a003223DOI Listing
January 2019
2 Reads

IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.

J Clin Invest 2019 Apr 2;130. Epub 2019 Apr 2.

OSE Immunotherapeutics, Nantes, France.

It remains unknown what causes inflammatory bowel disease (IBD), including signaling networks perpetuating chronic gastrointestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC), in humans. According to an analysis of up to 500 patients with IBD and 100 controls, we report that key transcripts of the IL-7 receptor (IL-7R) pathway are accumulated in inflamed colon tissues of severe CD and UC patients not responding to either immunosuppressive/corticosteroid, anti-TNF, or anti-α4β7 therapies. High expression of both IL7R and IL-7R signaling signature in the colon before treatment is strongly associated with nonresponsiveness to anti-TNF therapy. Read More

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http://dx.doi.org/10.1172/JCI121668DOI Listing
April 2019
2 Reads
13.215 Impact Factor

[Treat to target-participation of the patient].

Z Rheumatol 2019 Apr 1. Epub 2019 Apr 1.

Praxisgemeinschaft Rheumatologie Nephrologie, Erlangen, Deutschland.

An increase in general health literacy and a targeted patient information are important prerequisites for coping with the chronic disease in people with inflammatory rheumatic diseases. The education programs of the Working Group of Regional Cooperative Rheumatism Centers in the German Society for Rheumatology (AGRZ), such as StruPI, the offers of the German Rheumatism League (Deutsche Rheuma-Liga) and other elements provide a framework for those affected and their relatives, in which a participative decision-making (PEF) on equal terms can be possible. The physician-patient communication changes in the sense of a PEF and hopefully leads to a sustainably better patient compliance. Read More

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http://dx.doi.org/10.1007/s00393-019-0629-4DOI Listing
April 2019
1 Read

[Potential value of placental angiogenic factors as biomarkers in preeclampsia for clinical physicians].

Nephrol Ther 2019 Mar 30. Epub 2019 Mar 30.

Service de néphrologie et de dialyse de l'hôpital Américain de Paris, 63, boulevard Victor Hugo, 92200 Neuilly-sur-Seine, France; Service de néphrologie et de dialyse, hôpital Bichat, 46, rue Henri Huchard, 75018 Paris, France.

The role of angiogenic factors in the onset of clinical manifestations of preeclampsia was demonstrated in 2003 by the implication of sFlt-1, PlGF and VEGF, and in 2006 by the implication of soluble endoglin. Placental ischemia and inflammation observed in preeclampsia alter both the production and progression of angiogenic factors during pregnancy. During the first trimester, the combination of PlGF with clinical, biophysical and biological factors results in a better test than the conventional one. Read More

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http://dx.doi.org/10.1016/j.nephro.2018.10.005DOI Listing
March 2019
3 Reads