Search Our Scientific Publications & Authors

World J Urol 2020 May 27. Epub 2020 May 27.

Department of Urology, University of California, 333 City Blvd. West, Suite 2100, Irvine, Orange, CA, 92868, USA.

Purpose: To provide the first report of measuring intracalyceal pressures during ureteroscopy (URS).

Methods: A prospective single-center clinical study using a cardiac pressure guidewire to measure intracalyceal pressure during flexible URS was performed. Eight patients (45 calyces) undergoing URS for nephrolithiasis were included. Read More

Kidney Int 2020 Jun;97(6):1070-1073

Department of Medicine, Division of Nephrology, Duke University and Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address:

Urolithiasis 2020 May 20. Epub 2020 May 20.

Department of Urology, School of Medicine, Medicana Bahcelievler Hospital, Biruni University, Istanbul, Turkey.

Stone disease is a unique condition that requires appropriate management in a timely manner as it can result in both emergent conditions and long term effects on kidney functions. In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. The data of 473 patients from 11 centers in 5 different countries underwent interventions for urinary stones during the Covid-19 pandemic was collected and analyzed retrospectively. Read More

Exp Mol Pathol 2020 May 14;115:104450. Epub 2020 May 14.

Department of Geriatric Urology, Xiangya International Medical Center, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, PR China. Electronic address:

Nephrolithiasis is one of the most common and highly recurrent diseases worldwide. Accumulating evidence revealed the elevated miR-155 levels both in serum and urine of nephrolithiasis patients. The aim of our research was to explore the role of miR-155 in CaOx-induced apoptosis in HK-2 cells. Read More

Urolithiasis 2020 May 12. Epub 2020 May 12.

Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.

We have recently encountered patients incorrectly diagnosed with adenine phosphoribosyltransferase (APRT) deficiency due to misidentification of kidney stones as 2,8-dihydroxyadenine (DHA) stones. The objective of this study was to examine the accuracy of stone analysis for identification of DHA. Medical records of patients referred to the APRT Deficiency Research Program of the Rare Kidney Stone Consortium in 2010-2018 with a diagnosis of APRT deficiency based on kidney stone analysis were reviewed. Read More

Medicine (Baltimore) 2020 May;99(19):e19915

Department of Urology, Yangling Demonstration District Hospital, Xianyang, China.

Background: This study will assess the effectiveness and safety of extracorporeal shock wave lithotripsy (ESWL) for patients with kidney stones (KS).

Methods: A comprehensive and systematic literature records search for studies will be conducted in MEDLINE, EMBASE, Cochrane Library, WANGFANG, VIP, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All these databases will be searched from inception to the present without language limitation. Read More

World J Urol 2020 May 4. Epub 2020 May 4.

S.C. Nefrologia e Dialisi, A.O. Ordine Mauriziano di Torino, Largo Turati, 62, 10128, Turin, Italy.

Introduction: In this paper, we investigated whether cholecalciferol supplementation may increase the risk of stone recurrence in patients with calcium nephrolithiasis and Vitamin D deficiency.

Methods: Thirty-three stone formers (56 ± 17 years old, 12 males) with 25(OH)D < 20 ng/mL were considered. Calcium excretion and urine supersaturation with calcium oxalate (ßCaOx) and brushite (ßbsh) were evaluated, both before and after cholecalciferol supplementation. Read More

Urology 2020 Apr 17. Epub 2020 Apr 17.

Einstein Healthcare Network, Department of Urology, Philadelphia, PA; Fox Chase Cancer Center, Division of Urologic Oncology and Urology, Philadelphia, PA.

Objective: To identify how demographic factors, stone-associated medical comorbidities, and treatment predict compliance with 24-hour urine collection.

Materials And Methods: A retrospective medical record review of patients treated for urolithiasis between August 2014 and March 2017 was performed. Patient demographics, medical characteristics, stone factors, type of treatment, and compliance data were included for patients requested to submit a collection. Read More

Urolithiasis 2020 Apr 13. Epub 2020 Apr 13.

Ankara Yıldırım Beyazıt University, Faculty of Medicine, Department of Urology, Ankara State Hospital, Universiteler District, Bilkent Street, No:1, Cankaya, 06800, Ankara, Turkey.

Retrograde intrarenal surgery (RIRS) is one of the minimally invasive main treatment modalities in renal stone disease. There are many factors which affect stone-free rate (SFR). Our study was based on the hypothesis that higher renal parenchymal thickness (RPT) which may include higher average number of nephrons provides better diuresis. Read More

J Pediatr Urol 2020 Feb 22. Epub 2020 Feb 22.

Laboratory of Renal Lithiasis Research, University Institute of Health Sciences Research (IUNICS-IdISBa), University of Balearic Islands, Ctra Valldemossa, Km 7.5, 07122, Palma de Mallorca, Spain.

Introduction: The analysis of 24-h urine is the gold standard to diagnose metabolic abnormalities in the stone-forming patient. However, urinary composition changes throughout the day and analyzing the whole 24-h urine may mask peaks of increased risk of crystallization.

Objective: To examine variations of stone-promoting and stone-inhibiting factors in urine using split 24-h samples from healthy and stone-forming children. Read More

Acta Paediatr 2020 Apr 9. Epub 2020 Apr 9.

Center for Primary Health Care Research, Lund University, Malmö, Sweden.

Aim: To compare incidence of urolithiasis in second-generation immigrant children aged 0-17 years to children of Swedish-born parents.

Methods: A nationwide study of individuals residing in Sweden. Urolithiasis was defined as having at least one registered diagnosis of urolithiasis in the Swedish National Patient Register between January 1, 1998 and December 31, 2015. Read More

Arch Ital Urol Androl 2020 Apr 6;92(1):30-33. Epub 2020 Apr 6.

Department of Biotechnology and Life Sciences, Section of Medical and Surgical Sciences, University of Insubria, Varese, Italy; Faculty of Medicine and Medical Sciences, Ghent University.

Objective: Obesity has been associated with an increased risk of kidney stone formation. The presence of obesity is due to an imbalance between energy intake and energy consumption resulting from physical activity and resting metabolic rate. The purpose of this meta-analysis was to assess the differences in dietary energy intake levels between patients developing urinary stones versus healthy individuals. Read More

J Pediatr Urol 2020 Mar 19. Epub 2020 Mar 19.

Royal Manchester Children's Hospital, Manchester, UK.

Background: The epidemiology and risk factors for paediatric urolithiasis (UL) in developed countries are evolving, with increasing rates of metabolic stone-formers. In the United Kingdom (UK), only a single London cohort has been studied in the past three decades. Regional disease patterns across the UK remain unknown. Read More

Med Sci Monit 2020 Apr 3;26:e919360. Epub 2020 Apr 3.

Department of Pharmacy, Chongqing Three Gorges Central Hospital, Chongqing, China (mainland).

BACKGROUND This study aimed to undertake a network pharmacology analysis to identify the active compounds of the herbal extract Christina Loosestrife, or Lysimachia Christinae (Jin Qian Cao), in the treatment of nephrolithiasis. MATERIAL AND METHODS The active components of Christina Loosestrife were identified from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and analysis platform and the online Taiwan TCM database. The potentially active compounds were screened based on their parenteral bioavailability identified from the TCMSP database. Read More

Curr Urol Rep 2020 Mar 31;21(5):18. Epub 2020 Mar 31.

Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Purpose Of Review: From health systems to individuals, nephrolithiasis is economically burdensome. The aim of the current paper is to characterize the financial burden of disease associated with nephrolithiasis with an emphasis on investigating treatment modality economic efficiency.

Recent Findings: For small volume practices and cases where there is high risk of scope damage, disposable flexible ureteroscope utilization seems to provide economic efficiency. Read More

Medicine (Baltimore) 2020 Mar;99(13):e19611

The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi.

Introduction: Kidney stone is caused by abnormal accumulation of crystalline substances in the kidneys. Kidney stone is one of the urinary system diseases with a high incidence. In this study, we will use the research method of randomized controlled trials to explore the effects of Traditional Chinese medicine combined with western medicine on renal function and urine metabolism in women with kidney stones. Read More

Acta Paediatr 2020 Mar 25. Epub 2020 Mar 25.

University of Oviedo, Oviedo, Spain.

Aim: To describe incomplete distal renal tubular acidosis (iDRTA) in paediatric patients, a term used for the diagnosis of patients who do not develop spontaneous overt metabolic acidosis but are unable to acidify the urine in response to an ammonium chloride load.

Methods: Tests used to explore urinary acidification were revised. In addition, publications in English extracted from 161 entries yielded by a PubMed database search, using 'incomplete distal renal tubular acidosis' as keyword, were reviewed. Read More

World J Urol 2020 Mar 21. Epub 2020 Mar 21.

Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Landshuter Str. 65, 93053, Regensburg, Germany.

Purpose: Retrograde intrarenal surgery (RIRS) may require extensive X-ray usage. We evaluated the impact of preoperative surgeon briefing regarding the inclusion and evaluation of fluoroscopy time (FT) and dose area product (DAP) in a multicenter study on the applied X-ray usage.

Methods: A prospective multicenter study of 6 tertiary centers was performed. Read More

Urologiia 2020 Mar(1):39-45

Republican specialized scientific and practical medical center of urology, Tashkent, Uzbekistan.

Aim: To determine the complexity of urinary stones from the standpoint of endoscopic surgery in order to create the standard for the postoperative course of endoscopic surgery for urolithiasis.

Material And Methods: A total of 1317 endoscopic operations (PNL, URS), performed for upper urinary tract stones, were analyzed. Treatment results of 290 patients were studied prospectively, taking into account a stone density, determined by MSCT using HU scale. Read More

Chirurgia (Bucur) 2020 Jan-Feb;115(1):63-68

The retrograde flexible ureteroscopic approach is an effective and relatively safe procedure. The aim of this study was to retrospectively evaluate the safety of retrograde flexible ureteroscopic approach in patients with pyelo-caliceal stones on a significant number of cases. Material and method: We retrospectively evaluated 4500 procedures of flexible retrograde ureteroscopic approach for pyelocaliceal lithiasis, operated in two centers. Read More

Medicine (Baltimore) 2020 Mar;99(10):e19403

Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Hsinchu, Taiwan.

Background: Shock wave lithotripsy (SWL), retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PCNL), and minimally invasive PCNL are currently therapeutic options for lower-pole renal stones (LPS). However, the optimal treatment for LPS remains unclear. A comprehensive evaluation of the efficacy and safety of each intervention is needed to inform clinical decision-making. Read More

Eur Urol Focus 2020 Mar 4. Epub 2020 Mar 4.

Department of Urology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address:

Background: Water irrigant is discouraged in ureteroscopy due to risks demonstrated in more invasive endoscopic procedures. However, water is not well studied in ureteroscopy and may provide better visualization than standard saline.

Objective: To determine whether water irrigant increases the risk of hyponatremia compared with saline and provides better visualization in ureteroscopy. Read More

Turk J Urol 2020 03 1;46(2):89-94. Epub 2020 Mar 1.

Urological Surgery Department, University Hospital Southampton NHS Trust, Southampton, UK.

Objective: Management of nephrolithiasis during pregnancy can be challenging because of the potential risks to the mother and fetus. Diagnosis and treatment can be a dilemma owing to the anatomical and physiological changes, besides the limitation in the use of X-rays. The aim of this article was to identify any case series or case reports where percutaneous nephrolithotomy (PCNL) was used as a treatment modality for nephrolithiasis in pregnancy. Read More

Nat Rev Urol 2020 04;17(4):192-193

Nature Reviews Urology, .

Ghana Med J 2019 Dec;53(4):304-307

Department of Urology, 37 Military Hospital, Accra.

Objective: The purpose of this study was to determine the indications and complications of intracorporeal lithotripsy in our institution.

Methods: Retrospective study carried out at the urology unit of the 37 Military Hospital between 2012-2015. 42 patients had intracorporeal lithotripsy out of 359 patients who had surgery within the period. Read More

Urolithiasis 2020 Feb 27. Epub 2020 Feb 27.

Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland.

Objectives: To examine the stone recurrence rate among childhood kidney stone formers in the Icelandic population.

Materials And Methods: We retrospectively examined kidney stone recurrence in a recently reported population-based sample of 190 individuals who experienced their first stone before 18 years of age in the period 1985-2013. Of these 190 individuals, 112 (59%) were females and the median (range) age at the incident stone diagnosis was 15. Read More

Zhonghua Er Ke Za Zhi 2020 Feb;58(2):129-134

Department of Nephrology, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.

To investigate the clinical, imaging and molecular characteristics of primary hyperoxaluria type 1 (PH1) in children and to sum up existing evidence for further understanding the phenotype-genotype correlation of infantile PH1. This retrospective analysis was based on the medical records of children with PH1 diagnosed by gene test in the Department of Nephrology, Guangzhou Women and Children's Medical Center from June 2016 to May 2019. Targeted exome sequencing was performed on tubular disease-related genes of the probands and Sanger sequencing was conducted to validate suspected pathogenic variants of family members. Read More

Nutrients 2020 Feb 20;12(2). Epub 2020 Feb 20.

Geriatric-Rehabilitation Department, Azienda Ospedaliero-Universitaria di Parma, Via Antonio Gramsci 14, 43126 Parma, Italy.

Recent studies have shown that patients with kidney stone disease, and particularly calcium oxalate nephrolithiasis, exhibit dysbiosis in their fecal and urinary microbiota compared with controls. The alterations of microbiota go far beyond the simple presence and representation of , a well-known symbiont exhibiting a marked capacity of degrading dietary oxalate and stimulating oxalate secretion by the gut mucosa. Thus, alterations of the intestinal microbiota may be involved in the pathophysiology of calcium kidney stones. Read More

J Urol 2020 05 12;203(5):875. Epub 2020 Feb 12.

J Endourol 2020 Apr 6. Epub 2020 Apr 6.

UC San Diego Health, San Diego, California.

Cystinuria is a genetic disorder with both autosomal recessive and incompletely dominant inheritance. The disorder disrupts cystine and other dibasic amino acid transport in proximal tubules of the kidney, resulting in recurrent kidney stone formation. Currently, there are no consensus guidelines on evaluation and management of this disease. Read More

Am J Physiol Renal Physiol 2020 02;318(2):F506

Department of Urology and Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Am J Physiol Renal Physiol 2020 02;318(2):F507-F508

Division of Urology, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China.

Urologia 2020 May 10;87(2):57-64. Epub 2020 Feb 10.

Department of Medical Genetics, Sechenov University, Moscow, Russia.

The article summarizes the findings of Russian and international studies of the genetic aspects of polygenic urolithiasis associated with impairment of calcium metabolism. The article analyzes the genetic risk factors of polygenic nephrolithiasis that show significant association with the disease in case-control studies and Genome-Wide Association Studies (16 genes). We described the gene functions involved in concrement formation in polygenic nephrolithiasis. Read More

BMC Infect Dis 2020 Feb 5;20(1):105. Epub 2020 Feb 5.

Latvian Biomedical Research and Study Centre, Ratsupites Str 1, k-1, Riga, LV-1067, Latvia.

Background: Urogenital tuberculosis (TB) is rare in children and usually develops due to reactivation of the foci in the genitourinary tract after the latency period following initial infection. Urogenital TB in children has no pathognomonic clinical features that can result in overlooking or misdiagnosing this clinical entity. Here, we report important findings regarding the pathogenesis and transmission of TB by using genotyping and whole-genome sequencing (WGS) in a study of renal TB case in a child. Read More

Int Braz J Urol 2020 Mar-Apr;46(2):273-274

Serviço de Urologia, Hospital das Clínicas da Faculdade de Medicina da USP - HCFMUSP, São Paulo, SP, Brasil.

Int Braz J Urol 2020 Mar-Apr;46(2):271-272

Serviço de Urologia, Hospital das Clínicas da Faculdade de Medicina da USP - HCFMUSP, São Paulo, SP, Brasil.

Urologe A 2020 Mar;59(3):289-293

Regiomed-Klinikum Coburg, Regiomed Medical School Coburg, Universität Split, Ketschendorfer Str. 33, 96450, Coburg, Deutschland.

Compared with adults, urolithiasis is quite rare in children (1-2% of all urinary stones occur during childhood). In principle, all therapy modalities for adults can also be used in children. However, due to some anatomic and functional peculiarities in children, the differential indication for the various treatment modalities differ. Read More

Urologiia 2019 12(6):21-25

Department of urology of FGBOU VO North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.

Aim: to determine the efficiency of using a non-biological dismountable 3D-model of the collecting system with color segmentation for better understanding of its anatomy by residents and to determine the optimal tactics of percutaneous nephrolithotomy (PNL).

Materials And Methods: 3D-models of the collecting system were developed based on CT data of 5 patients with staghorn stones, for whom PNL was planned. CT images were obtained in the Dicom format. Read More

Am J Emerg Med 2020 Jan 8. Epub 2020 Jan 8.

Division of Urologic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Introduction: We sought quantify racial disparities in use of analgesia amongst patients seen in Emergency Departments for renal colic.

Methods: We identified all individuals presenting to the Emergency Department with urolithiasis from 2003 to 2015 in the nationally representative Premier Hospital Database. We included patients discharged in ≤1 day and excluded those with chronic pain or renal insufficiency. Read More

Urolithiasis 2020 Jan 24. Epub 2020 Jan 24.

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Via G. Moscati 31, 00168, Roma, Italia.

Due to the difficulty of collecting 24-h urines in the stone-forming patient, some authors have suggested other types of urine collection, but their usefulness is not yet well studied. The objective of this study is to evaluate the variation of urinary supersaturation (SS) throughout the day and to analyze whether timed urine collections offer accurate information. 48 urine samples were collected from 12 young adults. Read More

Nihon Hinyokika Gakkai Zasshi 2019 ;110(1):41-46

Department of Urology, Toranomon Hospital.

A 59-year-old female experienced gross hematuria and right back pain, and she visited our hospital in March 2015. Abdominal computed tomography (CT) showed bilateral renal pelvic calculi; the right stone was 15 mm and the left stone was 18 mm in diameter. She had ulcerative colitis and had been taking salazosulfapyridine (SASP) for about 30 years. Read More

Nat Rev Urol 2020 02;17(2):64

Nature Reviews Urology, .

Arch Esp Urol 2020 Jan;73(1):47-53

Department of Urology. Gulhane Training and Research Hospital. Ankara. Turkey.

Objectives: To evaluate the effect of silodosin on stages of the flexible ureterorenoscopy (F-URS) procedures.

Methods: Between November 2015 and August 2017, a total of 76 patients suffering from 10-30 mm kidney stone were enrolled in this randomized prospective study. Patients were randomly divided into 2 groups for treatment: Group 1 had F-URS with preoperative daily uptake of 8 mg silodosin for 10 days, and group 2 had F-URS without silodosin uptake. Read More

Arch Esp Urol 2020 Jan;73(1):26-31

Departamento de Urología. Hospital Universitario de Torrejón. Madrid. España.

Objective: To evaluate the impact of a new renal lithiasis classification on the stone free rate. The new system would allow standarization of comparison between different series of percutaneous nephrolithotomy.

Material And Methods: Patients undergoing NPCL between November 2011 and November 2016 were retrospectively analyzed. Read More

Hinyokika Kiyo 2019 Dec;65(12):507-511

The Department of Urology, Ijinkai Takeda General Hospital.

Metabolic syndrome, such as obesity and hyperglycemia, are associated with kidney stones, and there is an association between body mass index (BMI) and urolithiasis. Treatment of urinary calculi in obese patients is not rare, but radiography images are often unclear. Here we report a case of a morbidly obese patient (BMI, 54 kg/m2) with a ureteral stone, who successfully underwent transurethral ureterolithotripsy (TUL). Read More

J Pediatr Urol 2019 Dec 19. Epub 2019 Dec 19.

Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Drive, Suite 4230, Indianapolis, IN, 46202, USA.

Introduction And Objective: Endourological and percutaneous approaches are the standard of care for treatment of pediatric urolithiasis. However, in certain situations, an endoscopic-assisted robotic pyelolithotomy (EARP) can be an acceptable alternative. Limited data exist on pediatric EARP; thus, the authors describe their experience. Read More

Am J Emerg Med 2019 Dec 23. Epub 2019 Dec 23.

Department of Pharmacy, University of Rochester Medical Center, 601 Elmwood Ave., Box 638, Rochester, NY 14642, United States of America; Department of Emergency Medicine, University of Rochester Medical Center, 601 Elmwood Ave., Box 655, Rochester, NY 14642, United States of America.

Purpose: Evaluate opioid prescribing before and after emergency department (ED) renal colic guideline implementation focused on multi-modal pain management.

Methods: Retrospective study of ED patients who received analgesia for urolithiasis before and after guideline implementation. The guideline recommends oral acetaminophen, intravenous (IV) ketorolac, and a fluid bolus as first line, IV lidocaine as second line, and opioids as refractory therapy to control pain. Read More

J Urol 2020 04 13;203(4):657. Epub 2020 Jan 13.

J Zoo Wildl Med 2020 Jan;50(4):956-965

Northwest ZooPath, Monroe, WA 98272, USA.

Nephrolithiasis has been reported in several aquatic mammals including bottlenose dolphins (), small clawed otters (), European river otters (), North American river otters (), northern elephant seals (), Florida manatees (), and California sea lions (). Compositions of calculi in previous cases were predominantly calcium oxalate or ammonium acid urate. Xanthine urolithiasis is rare in veterinary medicine. Read More

J Vet Intern Med 2020 Mar 11;34(2):754-760. Epub 2020 Jan 11.

Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia.

Background: We aimed to identify a simple test for excessive calciuresis and predict calcium oxalate (CaOx) disease in Miniature Schnauzers. We investigated the impact of postprandial time on the urine calcium to creatinine ratio (UCa/Cr) in male dogs of this breed, with the goal of improving the utility of the UCa/Cr.

Hypotheses: (1) Significant differences will exist in preprandial and postprandial UCa/Cr between CaOx urolith-forming and control Schnauzers. Read More