24,703 results match your criteria Nephrolithiasis


Primary Contributors to Dietary Acid Load in Patients with Urolithiasis.

J Ren Nutr 2022 Jun 22. Epub 2022 Jun 22.

Senior Scientist, University of Wisconsin School of Medicine and Public Health, Department of Urology; and Clinical Nutritionist, UW Health University Hospital and Clinics, 1685 Highland Avenue, 3258 MFCB, Madison, WI 53705-2281.

Objective: In susceptible individuals, high dietary acid load may contribute to the formation of certain types of kidney stones via lowering urine pH and citrate excretion. The objective of this study was to determine the contribution of dietary acid from food groups in people with urolithiasis.

Design: & Methods: Patients with calcium urolithiasis (n=83) who completed food records were used for this retrospective analysis. Read More

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Oxidized forms of uromodulin promote calcium oxalate crystallization and growth, but not aggregation.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Roles of an abundant human urinary protein, uromodulin (UMOD), in kidney stone disease were previously controversial. Recently, we have demonstrated that oxidative modification reverses overall modulatory activity of whole urinary proteins, from inhibition to promotion of calcium oxalate (CaOx) stone-forming processes. We thus hypothesized that oxidation is one of the factors causing those previously controversial UMOD data on stone modulation. Read More

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Lumasiran in the Management of Patients with Primary Hyperoxaluria Type 1: From Bench to Bedside.

Int J Nephrol Renovasc Dis 2022 17;15:197-206. Epub 2022 Jun 17.

U.O.S. Terapia Conservativa della Malattia Renale Cronica, U.O.C. Nefrologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Primary hyperoxaluria (PH) is a rare genetic disease caused by excessive hepatic production and elevated urinary excretion of oxalate that leads to recurrent nephrolithiasis, nephrocalcinosis and, eventually, kidney failure. As glomerular filtration rate declines, oxalate accumulates leading to systemic oxalosis, a debilitating condition with high morbidity and mortality. Although PH is usually diagnosed during infancy, it can present at any age with different phenotypes, ranging from mild symptoms to extremely debilitating manifestations. Read More

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Genetic Variants Involved in the Crystallization Pathway Are Associated with Calcium Nephrolithiasis in the Chinese Han Population.

Genes (Basel) 2022 May 25;13(6). Epub 2022 May 25.

Department of Urology, Huashan Hospital & Institute of Urology, Fudan University, Shanghai 200040, China.

A genome-wide association analysis study (GWAS) in the Japanese population identified 14 significant loci associated with nephrolithiasis. Besides 4 novel loci related to metabolic traits, the 10 remaining loci were associated with kidney or electrolyte-related traits. We aimed to replicate the association of these loci with calcium nephrolithiasis in the Chinese Han population. Read More

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A multi-institutional study evaluating and describing atypical parathyroid tumors discovered after parathyroidectomy.

Laryngoscope Investig Otolaryngol 2022 Jun 19;7(3):901-905. Epub 2022 May 19.

Department of Otolaryngology - Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio USA.

Objective: To describe common intraoperative and pathologic findings of atypical parathyroid tumors (APTs) and evaluate clinical outcomes in patients undergoing parathyroidectomy.

Methods: In this multi-institutional retrospective case series, data were collected from patients who underwent parathyroidectomy from 2000 to 2018 from three tertiary care institutions. APTs were defined according to the AJCC eighth edition guidelines and retrospective chart review was performed to evaluate the incidence of recurrent laryngeal nerve injury, recurrence of disease, and disease-specific mortality. Read More

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Updated evidence of the safety and efficacy of the miniaturized percutaneous nephrolithotomy with holmium laser lithotripsy for the treatment of recurrent nephrolithiasis.

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3886-3892

Hanoi Medical College, Hanoi, Vietnam.

Objective: The objective of the present communication is to report the safety and efficacy of applying miniaturized percutaneous nephrolithotomy (mini-PCNL) in Vietnamese patients with recurrent kidney stones using a miniature nephroscope through a 18F metal access sheath.

Patients And Methods: We performed a retrospective cohort study of patients who were diagnosed with recurrent nephrolithiasis and underwent mini-PCNL after previous treatments between 2017 and 2020. Clinical profile, preoperative characteristics, intraoperative events, and postoperative outcomes were obtained from the hospital database. Read More

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Ureteroscopy with thulium fiber laser lithotripsy results in shorter operating times and large cost savings.

World J Urol 2022 Jun 21. Epub 2022 Jun 21.

Division of Urology, Maine Medical Center, 100 Brickhill Ave, South Portland, ME, 04106, USA.

Purpose: Prolonged ureteroscopy (URS) is associated with complications including ureteral perforation, stricture, and urosepsis. As laser lithotripsy is one of the most common urologic procedures, small cost savings per case can have a large financial impact. This retrospective study was designed to determine if Thulium fiber laser (TFL) lithotripsy decreases operative time and costs compared to standard Holmium:YAG (Ho:YAG) lithotripsy without pulse modulation. Read More

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Comparative effectiveness of high-power holmium laser lithotripsy for pediatric patients with kidney and ureteral stones.

J Pediatr Urol 2022 Jun 2. Epub 2022 Jun 2.

Department of Surgery, Division of Pediatric Urology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Background: The comparative effectiveness of high-power laser technology for kidney stone surgery in pediatric patients is poorly understood. We compared outcomes for the 120 W Holmium:yttrium-aluminum-garnet (Ho:YAG) laser with MOSES technology to 30 W Ho:YAG laser for pediatric patients undergoing ureteroscopy with laser lithotripsy for kidney and ureteral stones.

Objective: We evaluated the outcomes of the new MOSES laser technology as compared to low-power Ho:YAG lasers commonly used for kidney stone treatment in the pediatric population. Read More

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Associations of Obesity and Neighborhood Factors With Urinary Stone Parameters.

Am J Prev Med 2022 Jul;63(1S1):S93-S102

Department of Pediatrics, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.

Introduction: Obesity is associated with kidney stone disease, but it is unknown whether this association differs by SES. This study assessed the extent to which obesity and neighborhood characteristics jointly contribute to urinary risk factors for kidney stone disease.

Methods: This was a retrospective analysis of adult patients with kidney stone disease evaluated with 24-hour urine collection (2001-2020). Read More

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AKI in a Patient with Urinary Tract Infection, Urinary Crystals, and a Bladder Stone.

Kidney360 2022 Apr 3;3(4):790-792. Epub 2022 Mar 3.

Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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Sex Differences and the Risk of Kidney Stones.

Semin Nephrol 2022 Mar;42(2):230-235

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

A significant increase in the prevalence of kidney stones has been observed worldwide. In the past decades, this expansion was more pronounced among women than men. The precise mechanisms involved in the differences in the risk profile of stone disease between men and women have not been fully elucidated. Read More

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Clinical Course of Patients with Bartter Syndrome.

Iran J Kidney Dis 2022 May;16(3):162-170

1Intrdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Brazil.

Introduction: Bartter syndrome (BS) is a salt losing tubulopathy due to impairment of the transport mechanisms at the thick ascending limb of the Henle's loop. The aim of this study was to report the clinical course of patients with BS.

Methods: Patients with BS were followed from 1996 to 2020 and enrolled to a systematic protocol to confirm primary BS by evaluating the metabolic derangements, nephrolithiasis and nephrocalcinosis. Read More

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Twinkling-guided ultrasound detection of polymethyl methacrylate as a potential breast biopsy marker: a comparative investigation.

Eur Radiol Exp 2022 Jun 17;6(1):26. Epub 2022 Jun 17.

Department of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St, SW, Rochester, MN, 55905, USA.

Since its first description 25 years ago, color Doppler twinkling has been a compelling ultrasound feature in diagnosing urinary stones. While the fundamental cause of twinkling remains elusive, the distinctive twinkling signature is diagnostically valuable in clinical practice. It can be inferred that if an entity twinkles, it empirically has certain physical features. Read More

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The dilemma of 12/14F ureteral access sheath (UAS) usage: a case control study.

BMC Urol 2022 Jun 15;22(1):84. Epub 2022 Jun 15.

Department of Urology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Background: The insertion of a ureteral access sheath (UAS) is a frequent procedure during flexible ureteroscopy (fURS) to facilitate kidney stone treatment. The aim of this study was to investigate the influence of 12/14 French (F) UAS on fURS outcomes.

Methods: We performed a retrospective monocentric analysis of fURS procedures conducted at the Department of Urology (University Hospital Schleswig-Holstein, Lübeck, Germany) for kidney stone treatment via lithotripsy or basket stone retrieval between September 2013 and June 2017. Read More

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Fluconazole in hypercalciuric patients with increased 1,25(OH)D levels: the prospective, randomized, placebo-controlled, double-blind FLUCOLITH trial.

Trials 2022 Jun 16;23(1):499. Epub 2022 Jun 16.

Centre de Référence des Maladies Rénales Rares, filières maladies rares ORKID and ERK-Net, Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques, Hôpital Femme Mère Enfant, Boulevard Pinel, 69677, Bron, Cedex, France.

Background: Hypercalciuria is one of the most frequent metabolic disorders associated with nephrolithiasis and/or nephrocalcinosis possibly leading to chronic kidney disease (CKD) and bone complications in adults. Orphan diseases with different underlying primary pathophysiology share inappropriately increased 1,25(OH)D levels and hypercalciuria, e.g. Read More

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Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review.

Crit Rev Food Sci Nutr 2022 Jun 16:1-66. Epub 2022 Jun 16.

Natural Products for Neuroprotection and Anti-Ageing Research Unit, Chulalongkorn University, Bangkok, Thailand.

Age-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various disease conditions. Read More

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Decompensation of Cirrhosis: An Unusual Cause.

Cureus 2022 May 9;14(5):e24851. Epub 2022 May 9.

Gastroenterology, Jaslok Hospital and Research Centre, Mumbai, IND.

We describe a case of a 69-year-old woman, a known case of compensated Hepatitis C cirrhosis, presenting with recurrent urinary tract infection (UTI) secondary to . She had recently tested positive for bacteremia associated with UTI, managed with antibiotics. Two weeks later, she presented with fever and burning micturition with signs of abdominal distension and pedal edema suggestive of decompensation of cirrhosis. Read More

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Analysis and Characterization of Lactobacillus paragasseri and Lacticaseibacillus paracasei: Two Probiotic Bacteria that Can Degrade Intestinal Oxalate in Hyperoxaluric Rats.

Probiotics Antimicrob Proteins 2022 Jun 14. Epub 2022 Jun 14.

School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.

In the present study, we characterized the probiotic properties of two commercially available bacterial strains, Lactobacillus paragasseri UBLG-36 and Lacticaseibacillus paracasei UBLPC-87, and evaluated their ability to degrade oxalate in vitro and in a hyperoxaluria-induced nephrolithiasis rat model. UBLG-36 harboring two oxalate catabolizing genes, oxalyl coenzyme A decarboxylase (oxc) and formyl coenzyme A transferase (frc), was previously shown to degrade oxalate in vitro effectively. Here, we show that UBLPC-87, lacking both oxc and frc, could still degrade oxalate in vitro. Read More

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Decision-making and improvements in health-related quality of life in patients with kidney stones: comparing surgery versus observation using a mixed methods analysis.

Urolithiasis 2022 Jun 14. Epub 2022 Jun 14.

Department of Urology, Vanderbilt University Medical Center, 1161 21st Ave. South, A-1302 Medical Center North, Nashville, TN, 37232-2765, USA.

The experience of patients who choose observation or surgery for kidney stones has not been well established. We compared these patients using qualitative interviews, the Wisconsin Quality of Life questionnaire (WISQOL), and the Cambridge Renal Stone Patient Reported Outcome Measure (CReSP). Adult patients with upper tract urinary calculi for whom observation or intervention were options underwent qualitative interviews at baseline and at 2 months. Read More

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Understanding Causes for Admission in Planned Ambulatory Percutaneous Nephrolithotomy.

J Endourol 2022 Jun 14. Epub 2022 Jun 14.

University of California San Diego Health System, 21814, Urology, San Diego, California, United States;

Introduction: For treatment of nephrolithiasis, ambulatory percutaneous nephrolithotomy (aPCNL) is growing in popularity for select patients. The aim of this study was to investigate the safety and efficacy of a set of aPCNL selection criteria as well as search for predictors of failed aPCNL resulting in inpatient admission.

Methods And Materials: We reviewed all PCNL patients from 2016-2020. Read More

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[The assistant effects of porcine fibrin sealant in improving stone clearance rate in flexible ureteroscopy lithotripsy in porcine kidney model].

Zhonghua Yi Xue Za Zhi 2022 Jun;102(22):1660-1665

Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

To investigate the feasibility of using a porcine fibrin sealant to wrap and remove kidney calculi fragments through an isolated porcine kidney model. In the isolated porcine kidney stone model (implanted with 100 mg, air dried, ≤1 mm human stone fragments, =6;implanted with 100 mg, air dried, ≤3 mm human stone fragments, =6), the ureteral soft mirror combined with the 12/14Fr UAS was used to test the effect of stone extraction using only two stone extraction methods: basket extraction (control group, ≤1 mm stone fragments, =3; ≤3 mm stone fragments, =3) and basket-sealant extraction (test group, ≤1 mm stone fragments, =3; ≤3 mm stone fragments, =3). Compare the stone removal rate and operation time of the two stone retrieval methods. Read More

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Association Between Healthy Eating Index-2015 and Kidney Stones in American Adults: A Cross-Sectional Analysis of NHANES 2007-2018.

Front Nutr 2022 24;9:820190. Epub 2022 May 24.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Purpose: To explore the association between Healthy Eating Index (HEI)-2015 and kidney stones in an American adult population.

Materials And Methods: National Health and Nutrition Examination Survey (NHANES) datasets from 2007 to 2018 were used. Participants aged ≥ 20 years who reported kidney stone history and dietary recall were included. Read More

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Efficacy of Adjuvant Tamsulosin for Improving the Stone-Free Rate after Extracorporeal Shock Wave Lithotripsy in Renal Stones: A Randomized Controlled Trial.

Int J Clin Pract 2022 31;2022:3757588. Epub 2022 Jan 31.

Universidad de Guanajuato, Leon, Mexico.

Introduction: Extracorporeal shock wave lithotripsy (ESWL) is an effective treatment for urolithiasis. Tamsulosin is capable of causing dilation and facilitating the migration of stones. The aim of this study is to evaluate the efficacy of adjuvant treatment with tamsulosin for improving the stone-free rate after a single session of ESWL in the treatment of kidney stones. Read More

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Application of Suctioning Ureteral Access Sheath during Flexible Ureteroscopy for Renal Stones Decreases the Risk of Postoperative Systemic Inflammatory Response Syndrome.

Int J Clin Pract 2022 12;2022:9354714. Epub 2022 Mar 12.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: To clarify the efficiency and outcomes of suctioning ureteral access sheath (UAS) during flexible ureteroscopic lithotripsy (fURL) for the management of renal stones.

Methods: Between January 2017 and January 2019, a total of 444 patients with renal stones undergoing fURL were divided into suctioning UAS and nonsuctioning UAS groups. The outcomes of patients in both groups were compared using a matched-pair analysis (1 : 1 scenario). Read More

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Self-Medication with Drotaverine among Patients with Common Abdominal Symptoms and Treatment Efficacy from the Perspectives of Patients and General Practitioners-An Observational, Retrospective, Cross-Sectional Study Using Real-World Data.

J Clin Med 2022 Jun 1;11(11). Epub 2022 Jun 1.

PEX PharmaSequence Sp. z o.o., Ul. Klobucka 23, 02-699 Warszawa, Poland.

In Poland, drotaverine is the most frequently purchased antispasmodic, yet there is a paucity of real-world data on its use. We evaluated the profiles of patients who used drotaverine, and we investigated prescription patterns among general practitioners (GPs). In this cross-sectional, questionnaire-based study, we asked patients who purchased drotaverine about their reasons for using it, its perceived efficacy, satisfaction with treatment, and physician consultation. Read More

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Primary hyperoxaluria and genetic linkages: an insight into the disease burden from Pakistan.

Urolithiasis 2022 Jun 9. Epub 2022 Jun 9.

Department of Pathology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Autosomal recessive disorders are prevalent in Pakistan, a developing South Asian country where consanguineous marriages are common. This study seeks to determine the prevalence of monogenic causes in children presenting with nephrocalcinosis and nephrolithiasis at a dialysis and transplant center in Karachi, Pakistan. A retrospective analysis was conducted in children aged 1-18 years presenting with nephrocalcinosis, between 2010 and 2019. Read More

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Efficacy of PCNL in the resolution of symptoms of nephrolithiasis.

Urolithiasis 2022 Jun 8. Epub 2022 Jun 8.

Department of Urology, AIIMS, Bhubaneshwar, Odisha, India.

Patients undergo Percutaneous Nephrolithotomy (PCNL) for the resolution of pain, but at times, other symptoms such as hematuria, dysuria, nausea, emotional distress, and anxiety are also the presenting symptoms. While pain resolution after successful surgery is generally the focus, the resolution rate of other symptoms after surgery is not described. Our study aims to determine the efficacy of PCNL for the resolution of other symptoms. Read More

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Sex disparities and the risk of urolithiasis: a large cross-sectional study.

Ann Med 2022 Dec;54(1):1627-1635

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Urolithiasis is one of the most common diseases in urology, with a lifetime prevalence of 14% and is more prevalent in males compared to females. We designed to explore sex disparities in the Chinese population to provide evidence for prevention measures and mechanisms of stone formation.

Materials And Methods: A total of 98232 Chinese individuals who had undergone a comprehensive examination in 2017 were included. Read More

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December 2022