21,428 results match your criteria Nephrolithiasis


ALLN-177, oral enzyme therapy for hyperoxaluria.

Int Urol Nephrol 2019 Feb 19. Epub 2019 Feb 19.

Feinberg School of Medicine, Northwestern University, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Avenue, Chicago, IL, 60611, USA.

Purpose: To evaluate the potential of ALLN-177, an orally administered, oxalate-specific enzyme therapy to reduce urine oxalate (UOx) excretion in patients with secondary hyperoxaluria.

Methods: Sixteen male and female subjects with both hyperoxaluria and a kidney stone history were enrolled in an open-label study. Subjects continued their usual diets and therapies. Read More

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http://dx.doi.org/10.1007/s11255-019-02098-1DOI Listing
February 2019

Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis.

Sci Rep 2019 Feb 19;9(1):2282. Epub 2019 Feb 19.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, 92093-0747, USA.

Proton pump inhibitors, PPIs, are widely prescribed and sold globally. Although initially intended for time-limited treatment of acute disorders, such as gastric ulcers and esophagitis, PPIs are now commonly used for prolonged durations and are considered safe for over the counter access. Recent studies have raised concern over associations between PPI use and acute kidney injury, chronic kidney disease, end-stage renal disease, and electrolyte abnormalities. Read More

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http://www.nature.com/articles/s41598-019-39335-7
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http://dx.doi.org/10.1038/s41598-019-39335-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381091PMC
February 2019
1 Read

Gene panel sequencing identifies a likely monogenic cause in 7% of 235 Pakistani families with nephrolithiasis.

Hum Genet 2019 Feb 18. Epub 2019 Feb 18.

Division of Nephrology, Department of Medicine, Harvard Medical School, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.

Nephrolithiasis (NL) affects 1 in 11 individuals worldwide and causes significant patient morbidity. We previously demonstrated a genetic cause of NL can be identified in 11-29% of pre-dominantly American and European stone formers. Pakistan, which resides within the Afro-Asian stone belt, has a high prevalence of nephrolithiasis (12%) as well as high rate of consanguinity (> 50%). Read More

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http://dx.doi.org/10.1007/s00439-019-01978-xDOI Listing
February 2019

Treatment and long-term outcome in primary distal renal tubular acidosis.

Nephrol Dial Transplant 2019 Feb 18. Epub 2019 Feb 18.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

Background: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome.

Methods: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. Read More

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http://dx.doi.org/10.1093/ndt/gfy409DOI Listing
February 2019
1 Read
3.577 Impact Factor

Fluconazole as a New Therapeutic Tool to Manage Patients With NPTIIc (SLC34A3) Mutation: A Case Report.

Am J Kidney Dis 2019 Feb 11. Epub 2019 Feb 11.

Centre de Référence des Maladies Rénales Rares, filière ORKID, Service de Néphrologie, Rhumatologie et Dermatologie Pédiatriques; Centre de Référence des Maladies Rares du Calcium et du Phosphate, filière OSCAR; Faculté de Médecine Lyon Est, Université Lyon 1, Lyon; INSERM 1033, Prévention des Maladies Osseuses, Lyon, France. Electronic address:

Mutations in the SLC34A3 gene, encoding the sodium/phosphate cotransporter 2C (NPTIIc), induce decreased renal phosphate reabsorption, hypophosphatemia, decreased fibroblast growth factor 23 and parathyroid hormone, and increased 1,25-dihydroxyvitamin D (1,25[OH]D) levels. The complete phenotype is characterized by hypophosphatemia, hypercalciuria, and nephrolithiasis/nephrocalcinosis, leading to chronic kidney disease and osteoporosis in adults. We report a 15-year-old boy referred for nephrocalcinosis. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.026DOI Listing
February 2019
1 Read

[Genetic factors for monogenic forms of calcium urolithiasis].

Urologiia 2018 Oct(4):154-160

I.M. Sechenov First MSMU of Minzdrav of Russia, Moscow, Russia.

The article presents pooled results of domestic and international studies investigating genetic aspects of urolithiasis associated with impaired calcium metabolism. The review highlights the importance of early and accurate diagnosis of hereditary diseases associated with kidney stone formation. Of more than 80 currently known monogenic forms of urolithiasis, the authors provide the list of the most significant forms. Read More

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October 2018
3 Reads

[Multi-tract percutaneous nephrolithotomy in the management of staghorn stones].

Urologiia 2018 Oct(4):96-101

N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology branch of the NMRRC of Minzdrav of Russia, Moscow, Russia.

Aim: To compare the results of a single tract versus multi-tract percutaneous nephrolithotomy (PNL) MATERIALS AND METHODS: Over a period of 6 years, a total of 2,264 PNLs was performed at the N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology, of which 875 PNLs were done for stage K3-K4 staghorn calculi. Read More

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October 2018
4 Reads

Net Acid Excretion and Urinary Organic Anions in Idiopathic Uric Acid Nephrolithiasis.

Clin J Am Soc Nephrol 2019 Feb 11. Epub 2019 Feb 11.

Department of Internal Medicine,

Background And Objectives: Idiopathic uric acid nephrolithiasis, which is closely associated with obesity and the metabolic syndrome, is increasing in prevalence. Unduly acidic urine pH, the quintessential pathophysiologic feature of this disease, is in part explained by inadequate excretion of the principal urinary buffer ammonium. The role of net acid excretion in the pathogenesis of uric acid nephrolithiasis is incompletely understood. Read More

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http://dx.doi.org/10.2215/CJN.10420818DOI Listing
February 2019
2 Reads

Metabolomic and lipidomic characterization of Oxalobacter formigenes strains HC1 and OxWR by UHPLC-HRMS.

Anal Bioanal Chem 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, 32610, USA.

Diseases of oxalate, such as nephrolithiasis and primary hyperoxaluria, affect a significant portion of the US population and have limited treatment options. Oxalobacter formigenes, an obligate oxalotrophic bacterium in the mammalian intestine, has generated great interest as a potential probiotic or therapeutic treatment for oxalate-related conditions due to its ability to degrade both exogenous (dietary) and endogenous (metabolic) oxalate, lowering the risk of hyperoxaluria/hyperoxalemia. Although all oxalotrophs degrade dietary oxalate, Oxalobacter formigenes is the only species shown to initiate intestinal oxalate secretion to draw upon endogenous, circulating oxalate for consumption. Read More

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http://dx.doi.org/10.1007/s00216-019-01639-yDOI Listing
February 2019
1 Read

Exacerbation of Cushing's syndrome during pregnancy: stimulation of a cortisol-secreting adrenocortical adenoma by ACTH originating from the foeto-placental unit.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

A 29-year-old G4A3 woman presented at 25 weeks of pregnancy with progressive signs of Cushing's syndrome (CS), gestational diabetes requiring insulin and hypertension. A 3.4 × 3. Read More

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http://dx.doi.org/10.1530/EDM-18-0115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373782PMC
February 2019
1 Read

Metabolomic Analysis Reveals a Protective Effect of Fu-Fang-Jin-Qian-Chao Herbal Granules on Oxalate-Induced Kidney Injury.

Biosci Rep 2019 Feb 8. Epub 2019 Feb 8.

Changhai Hospital, Second Military Medical University, Shanghai, 200433, China

Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20181833
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http://dx.doi.org/10.1042/BSR20181833DOI Listing
February 2019
5 Reads

Medical and Interventional Management of Upper Urinary Tract Uroliths.

Vet Clin North Am Small Anim Pract 2019 Mar;49(2):157-174

The Animal Medical Center, 510 East 62nd Street, New York, NY 10065, USA.

Nephroliths are often clinically silent. When non-obstructive and of an amenable stone type, dissolution should be attempted. When problematic, nephrolithotomy can be considered. Read More

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http://dx.doi.org/10.1016/j.cvsm.2018.11.004DOI Listing
March 2019
1 Read

Multimodality appearance of multiple endocrine neoplasia type 1: A case report.

Radiol Case Rep 2019 Apr 23;14(4):439-443. Epub 2019 Jan 23.

Advocate Illinois Masonic Medical Center, 836 W Wellington Ave, Chicago, IL 60657, USA.

Multiple endocrine neoplasia type 1 is a rare autosomal dominant disorder classically characterized by a predisposition to tumors of the parathyroid glands, anterior pituitary, and enteropancreatic endocrine cells. We present the clinical details of a patient with diarrhea, nephrolithiasis, erectile dysfunction, and new onset abdominal pain, as well as a discussion of the etiology, pathophysiology, and classical imaging findings of this condition. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352705PMC
April 2019
1 Read

Low Sodium Diet Decreases Stone Formation in Genetic Hypercalciuric Stone-Forming Rats.

Nephron 2019 Feb 6:1-11. Epub 2019 Feb 6.

Division of Nephrology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.

Background: Urine (u) calcium (Ca) excretion is directly dependent on dietary sodium (Na) intake leading to the recommendation for Na restriction in hypercalciuric kidney stone formers. However, there is no direct evidence that limiting Na intake will reduce recurrent stone formation.

Materials And Methods: We used genetic hypercalciuric stone-forming (GHS) rats, which universally form Ca phosphate (P) kidney stones, fed either a low Na (LNa, 0. Read More

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http://dx.doi.org/10.1159/000497117DOI Listing
February 2019
4 Reads

Hyperuricemia, urine uric excretion, and associated complications in thalassemia patients.

Ann Hematol 2019 Feb 5. Epub 2019 Feb 5.

Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Thalassemia patients have a high cell turnover rate due to chronic hemolysis and ineffective erythropoiesis; therefore, hyperuricemia is anticipated. This study aimed to identify the prevalence of hyperuricemia, gout and nephrolithiasis, conditions associated with serum uric acid (SUA), and urine uric acid excretion (UUA) in thalassemia patients. This was a cross-sectional study in patients aged 15 years or older at Chiang Mai University Hospital. Read More

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http://dx.doi.org/10.1007/s00277-019-03630-0DOI Listing
February 2019
2 Reads
2.634 Impact Factor

Metformin prevents nephrolithiasis formation by inhibiting the expression of OPN and MCP-1 in vitro and in vivo.

Int J Mol Med 2019 Jan 30. Epub 2019 Jan 30.

Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Hexi, Tianjin 300211, P.R. China.

Treatment targeting osteopontin (OPN) and monocyte chemoattractant protein 1 (MCP‑1) has been recognized as a novel approach in renal crystal formation. The present study was designed to investigate the suppressive effects of metformin on nephrolithiasis formation and its potential mechanism. The cytotoxicity of metformin on MDCK and HK‑2 cells was determined using a Cell Counting Kit‑8 assay in vitro. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4084DOI Listing
January 2019
1 Read
1.880 Impact Factor

Association of sirtuin 1 gene polymorphisms with nephrolithiasis in Eastern chinese population.

Ren Fail 2019 Nov;41(1):34-41

a Department of Nephrology , Shanghai Changhai Hospital , Shanghai , China.

Sirtuin 1 (SIRT1), an NAD-dependent deacylase, has been identified to be associated with renal tubular inflammatory conditions and metabolic disorders, which are risk factors of nephrolithiasis. To further confirm the role of the SIRT1 in kidney stone formation, the expression of SIRT1 was analyzed based on a mouse model and the genetic polymorphisms of SIRT1 gene was compared between patients with kidney stones and controls. The calcium oxalate (CaOx) crystal-induced renal injury model was established to analyzed the expression of SIRT1 in the kidney tissue of both wild-type and ApoE(-/-) mice. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1568258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366414PMC
November 2019
1 Read

Hereditary renal hypouricemia type 1 and 2 in three spanish children. Revision of published pediatric cases.

Nefrologia 2019 Jan 28. Epub 2019 Jan 28.

Hospital Clínico Universitario, Valencia, España.

Hereditary renal hypouricemia is a rare autosomal recessive genetic disorder that involves an isolated defect in uric acid reabsorption at the renal tubules. Patients present with serum uric acid concentrations of less than 2mg/dl (119 micromol/L) with increased fractional excretion above 10%. Most of the patients are asymptomatic and are detected incidentally. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.08.010DOI Listing
January 2019

Nephrological aspects of surgical weight correction in morbid obesity.

Ter Arkh 2018 Jun;90(6):98-104

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Obesity, including morbid obesity, is a growing worldwide problem. The adverse effect of obesity on the kidneys is associated with the development of comorbid conditions, such as insulin resistance (IR), metabolic syndrome (MS), diabetes mellitus (DM), arterial hypertension (AH), which are the recognized risk factors of chronic kidney disease (СKD). Obesity also causes direct kidney damage with the development of non-immune focal segmental glomerulosclerosis. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-6-2018/15_2731/?
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http://dx.doi.org/10.26442/terarkh201890698-104DOI Listing
June 2018
9 Reads

Nephrolithiasis against type 2 diabetes mellitus: on the effect of hypoglycemic therapy on lithogenesis.

Ter Arkh 2018 Nov;90(10):60-64

N.A. Lopatkin Scientific Research Institute of Urology and Interventional Radiology - branch of the National Medical Research Center of Radio-logy, Ministry of Health of Russia, Moscow, Russia.

Aim: To study the effects of oral hypoglycemic agents that can affect the probability of recurrence of nephrolithiasis.

Materials And Methods: The article is based on the results of examination and treatment of 315 patients suffering from recurrent nephroli-thiasis and medically compensated type 2 diabetes mellitus treated at the N.A. Read More

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http://dx.doi.org/10.26442/terarkh2018901060-64DOI Listing
November 2018
1 Read

Association of vitamin D receptor gene polymorphism with the risk of nephrolithiasis.

Ther Apher Dial 2019 Jan 30. Epub 2019 Jan 30.

Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, China.

Backound: This study aimed to explore the the relationship between vitamin D receptor (VDR) gene polymorphisms and the risk of nephrolithiasis.

Methods: All relevant trials were searched from multiple databases according to predefined criteria, the pooled odds ratio (OR) and corresponding 95% confidence interval (CI) were analyzed using Stata software.

Results: 17 studies involving with 2441 cases and 2296 controls were included. Read More

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http://dx.doi.org/10.1111/1744-9987.12797DOI Listing
January 2019
4 Reads
1.532 Impact Factor

Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation.

Cell Death Discov 2019 28;5:57. Epub 2019 Jan 28.

1Laboratory of Kidney Histomorphology and Molecular Biology, Clinical Nephrology, Department of Medicine-DIMED, University of Padova, Padova, Italy.

Nephrocalcinosis is a clinicopathological entity characterized by microscopic calcium crystals in the renal parenchyma, within the tubular lumen or in the interstitium. Crystal binding to tubular cells may be the cause underlying nephrocalcinosis and nephrolithiasis. Pathological circumstances, such as acute cortical necrosis, may induce healthy cells to acquire a crystal-binding phenotype. Read More

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http://dx.doi.org/10.1038/s41420-019-0138-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349935PMC
January 2019
2 Reads

Successful Distal Urethral Stone Removal in the Emergency Department.

Am J Emerg Med 2019 Jan 25. Epub 2019 Jan 25.

Medical University of South Carolina, Department of Emergency Medicine, United States of America.

Nephrolithiasis is a common pathology encountered in the primary care and emergency department (ED) setting. In 2009 alone, there were over one million ED visits related to nephrolithiasis Higa et al. (2017) [1]. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.01.045DOI Listing
January 2019
1 Read

Impact of the Image Gently Campaign on Computerized Tomography Use for Evaluation of Pediatric Nephrolithiasis.

J Urol 2019 Jan 31. Epub 2019 Jan 31.

Department of Urology, University of Michigan, Ann Arbor, Michigan.

Purpose: The Image Gently® campaign was launched by several radiological societies in 2007 to promote safe imaging in children. A goal of the campaign was to reduce ionizing radiation exposure in children. Given the recurrent nature of kidney stones, affected children are at risk for unnecessary ionizing radiation exposure from computerized tomography. Read More

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http://dx.doi.org/10.1097/JU.0000000000000030DOI Listing
January 2019
2 Reads

Total serum magnesium in cats with chronic kidney disease with nephrolithiasis.

J Feline Med Surg 2019 Jan 29:1098612X18823588. Epub 2019 Jan 29.

Internal Medicine, School of Veterinary Medicine and Animal Science/University of Sao Paulo, Sao Paulo, Brazil.

Objectives: Magnesium has been 'the forgotten ion' for many years. Over the past decade, however, the role of magnesium in essential physiological functions and several illness conditions have been elucidated. Nevertheless, the investigation of magnesium in cats with chronic kidney disease (CKD) and nephrolithiasis is yet to be determined. Read More

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http://dx.doi.org/10.1177/1098612X18823588DOI Listing
January 2019
1 Read

De novo nephrolithiasis causing acute renal transplant dysfunction.

Am J Transplant 2019 Feb;19(2):603-605

Division of Nephrology, Department of Medicine, Western University, London, ON, Canada.

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http://dx.doi.org/10.1111/ajt.15235DOI Listing
February 2019
1 Read

Hepatoid adenocarcinoma of the renal pelvis in a 59-year-old male with nephrolithiasis: Case report and review of the literature.

Curr Probl Cancer 2019 Jan 17. Epub 2019 Jan 17.

Department of Urology, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of SUN YAT-SEN University, Jiangmen, Guangdong, China.

Background: Hepatoid adenocarcinoma arising from urological system is extremely rare, and the pathogenesis and therapeutic regimen have been poorly understood.

Case Report: we report a unique case of ɑ-fetaprotein (AFP)-producing neoplasm of renal pelvis associated with nephrolithiasis. A 59-year-old male patient was diagnosed with right renal tumor and nephrolithiasis with no evidence of lesions in his digestive or reproductive system. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2018.12.007DOI Listing
January 2019
2 Reads

Meeting report of the "Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017".

J Nephrol 2019 Jan 24. Epub 2019 Jan 24.

Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

A symposium on kidney stones and mineral metabolism held on December 2017 in Brussels, Belgium was the first international multidisciplinary conference of the International Collaborative Network on Kidney Stones and Mineral Metabolism. This meeting addressed epidemiology, underlying pathophysiological mechanisms, genetics, pathological, as well as clinical and research topics. The participants included clinicians and recognized experts in the field from Europe and the United States interacted closely during the symposium which promoted a chance to explore new frontiers in the field of kidney stone disease. Read More

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http://dx.doi.org/10.1007/s40620-019-00587-1DOI Listing
January 2019
1 Read

Trends in renal calculus composition and 24-hour urine analyses in patients with neurologically derived musculoskeletal deficiencies.

Int Braz J Urol 2019 Jan 4;45. Epub 2019 Jan 4.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Purpose: To better characterize metabolic stone risk in patients with neurologically derived musculoskeletal deficiencies (NDMD) by determining how patient characteristics relate to renal calculus composition and 24-hour urine parameters.

Materials And Methods: We performed a retrospective cohort study of adult patients with neurologically derived musculoskeletal deficiencies presenting to our multidisciplinary Kidney Stone Clinic. Patients with a diagnosis of NDMD, at least one 24-hour urine collection, and one chemical stone analysis were included in the analysis. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0531DOI Listing
January 2019
1 Read

Sirt3 suppresses calcium oxalate-induced renal tubular epithelial cell injury via modification of FoxO3a-mediated autophagy.

Cell Death Dis 2019 Jan 15;10(2):34. Epub 2019 Jan 15.

Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.

High oxalic acid and calcium oxalate (CaOx)-induced renal tubular epithelial cell (TEC) injury plays a key role in nephrolithiasis. However, the mechanism remains unknown. Gene array analysis of the mice nephrolithiasis model indicated significant downregulation of sirtuin 3 (Sirt3) and activation of mitogen-activated protein kinase (MAPK) pathway. Read More

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http://www.nature.com/articles/s41419-018-1169-6
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http://dx.doi.org/10.1038/s41419-018-1169-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377683PMC
January 2019
13 Reads

Inherited proximal tubular disorders and nephrolithiasis.

Urolithiasis 2019 Feb 23;47(1):35-42. Epub 2019 Jan 23.

Royal Free Hospital/Medical School, Centre for Nephrology, University College London, London, NW3 2PF, UK.

The proximal tubule is responsible for reclaiming water, phosphates and amino acids from the tubular filtrate. There are genetic defects in both phosphate and amino acid transporters leading to nephrolithiasis. This review also explores genetic defects in regulators of phosphate and calcium transport in this nephron segment that lead to stone formation. Read More

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http://dx.doi.org/10.1007/s00240-018-01103-zDOI Listing
February 2019
1 Read

Association between Dyslipidemia and Nephrolithiasis Risk in a Chinese Population.

Urol Int 2019 Jan 23:1-10. Epub 2019 Jan 23.

Department of Gastroenterology, The Changshu Hospital Affiliated to Soochow University, Changshu, China.

Purpose: To evaluate the association between dyslipidemia and nephrolithiasis risk in a Chinese population.

Materials And Methods: Fasting plasma lipid profiles were measured in a case-control study of 540 nephrolithiasis cases and 656 kidney stone-free controls.

Results: Triglycerides (TG) levels were significantly higher, but total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels were significantly lower in nephrolithiasis patients than those in the control group (each p < 0. Read More

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https://www.karger.com/Article/FullText/496208
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http://dx.doi.org/10.1159/000496208DOI Listing
January 2019
4 Reads
1.151 Impact Factor

Management of normocalcemic primary hyperparathyroidism.

Best Pract Res Clin Endocrinol Metab 2018 Dec 28;32(6):837-845. Epub 2018 Sep 28.

Metabolic Bone Diseases Unit, Division of Endocrinology, Department of Medicine, College of Physician and Surgeons, Columbia University, 630 West 168th St, New York, NY, 10032, USA. Electronic address:

Traditional hypercalcemic primary hyperparathyroidism is a common endocrine disease. Patients with a history of nephrolithiasis or a suspected metabolic bone disease are increasingly being identified with elevated PTH concentrations in the setting of consistently normal serum and ionized calcium concentrations. In the absence of secondary causes of hyperparathyroidism, a diagnosis of normocalcemic primary hyperparathyroidism is reasonable. Read More

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http://dx.doi.org/10.1016/j.beem.2018.09.009DOI Listing
December 2018
1 Read

[A CASE REPORT: LITHIASIS OF THE LEFT ECTOPIC PELVIC KIDNEY].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):54-57

The Department of Urology, Osaka Police Hospital.

We report a case of lithiasis of the left ectopic pelvic kidney. A 70-year-old man was admitted to our department for left lower back pain. He has been aware of gross hematuria since three or four years before. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.54DOI Listing
February 2019
1 Read

[A CASE OF RETROPERITONEAL HEMORRHAGE CAUSED BY THE INSERTION OF A URETERAL ACCESS SHEATH. A RARE COMPLICATION ASSOCIATED WITH FLEXIBLE TRANSURETHRAL LITHOTRIPSY (fTUL)].

Nihon Hinyokika Gakkai Zasshi 2018 ;109(1):50-53

Department of Urology, Toyohashi Municipal Hospital.

A 77-year-old man with a right kidney stone was admitted to our hospital. A ureteroscope was introduced into the ureter without dilation under direct vision. We then performed flexible transurethral lithotripsy (f-TUL) using a ureteral access sheath and successfully fragmented the stone and extracted almost all the stone fragments without any complications. Read More

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http://dx.doi.org/10.5980/jpnjurol.109.50DOI Listing
February 2019
2 Reads

Are Emergently Placed Nephrostomy Tubes Suitable for Subsequent Percutaneous Endoscopic Renal Surgery?

Urology 2019 Jan 15. Epub 2019 Jan 15.

Department of Urology, George Washington University Medical School, (GWUH), Washington, DC.

Objective: To determine the percentage of emergently placed nephrostomy tubes (NT) that were subsequently deemed usable for definitive percutaneous nephrolithotomy or percutaneous antegrade ureteroscopy in patients presenting with nephrolithiasis.

Methods: A multi-institutional retrospective database review was completed to identify patients who underwent emergent NT placement and then subsequent percutaneous nephrolithotomy or percutaneous antegrade ureteroscopy. Demographic, operative, and postoperative data were collected. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.006DOI Listing
January 2019
5 Reads

A prospective study evaluating impact on renal function following percutaneous nephrolithotomy using Tc99m ethylenedicysteine renal scan: Does multiplicity of access tracts play a role?

Investig Clin Urol 2019 Jan 27;60(1):21-28. Epub 2018 Nov 27.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

Purpose: A prospective study evaluating impact of percutaneous nephrolithotomy (PCNL) on renal function following PCNL using ethylenedicysteine (EC) renal scan. Does multiplicity of access tracts play a role?

Materials And Methods: A prospective observational study was done and patients undergoing PCNL for renal calculi at our urology department were selected. Renal Tc99m EC scan was done pre-surgery and at 3 months follow-up. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4111/icu.2019.60
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http://dx.doi.org/10.4111/icu.2019.60.1.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318208PMC
January 2019
4 Reads

Editorial Comment.

Authors:
Kirill Shiranov

J Urol 2019 02;201(2):356-357

CDC Zdorovie, Rostov-on-Don, Russia.

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http://dx.doi.org/10.1097/01.JU.0000553000.50724.d4DOI Listing
February 2019
1 Read

Editorial Comment.

Authors:
Ryan S Hsi

J Urol 2019 02;201(2):356

Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1097/01.JU.0000552999.43100.d4DOI Listing
February 2019
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Changing Trends in the Treatment of Nephrolithiasis in the Real World.

J Endourol 2019 Feb 13. Epub 2019 Feb 13.

1 Department of Urology, Stanford University Medical Center, Stanford, California.

Introduction: Changes in the surgical treatment of nephrolithiasis, owing to recent technical advances and innovations, have made treatments more effective and less invasive. In this retrospective, observational cohort study, we identified the changing trends in the treatment of nephrolithiasis.

Materials And Methods: We included patients with newly diagnosed nephrolithiasis who received any treatment in the United States, including extracorporeal shockwave lithotripsy (SWL), retrograde intrarenal surgery (RIRS), percutaneous nephrolithotomy (PCNL), and open surgery, from January 2007 to December 2014. Read More

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https://www.liebertpub.com/doi/10.1089/end.2018.0667
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http://dx.doi.org/10.1089/end.2018.0667DOI Listing
February 2019
5 Reads
2.095 Impact Factor

Randomized controlled trial of vitamin D supplementation in older people to optimize bone health.

Am J Clin Nutr 2019 Jan;109(1):207-217

MRC Elsie Widdowson Laboratory, Cambridge, United Kingdom.

Background: Vitamin D insufficiency is common in older people and may lead to increased bone resorption, bone loss, and increased falls and fractures. However, clinical trials assessing the effect of vitamin D supplementation on bone mineral density (BMD) have yielded conflicting results.

Objectives: This study examined the effect of vitamin D supplementation on BMD at the hip, using dual-energy X-ray absorptiometry. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqy280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358029PMC
January 2019
13 Reads

Activation of liver X receptor suppresses osteopontin expression and ameliorates nephrolithiasis.

J Cell Physiol 2019 Jan 8. Epub 2019 Jan 8.

Division of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Nephrolithiasis is a common disease of the urinary system, of which idiopathic calcium oxalate (CaOx) kidney stones, in particular, are one of the special types. In the initial stages of CaOx kidney stone formation, Randall's plaques (RPs) develop. Liver X receptors (LXRs) inhibit oxidative stress and inflammatory in other diseases; nevertheless, the role of LXRs in nephrolithiasis has yet to be elucidated. Read More

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http://doi.wiley.com/10.1002/jcp.28101
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http://dx.doi.org/10.1002/jcp.28101DOI Listing
January 2019
6 Reads
3.839 Impact Factor

Opiate Exposure and Predictors of Increased Opiate Use After Ureteroscopy.

J Endourol 2019 Feb 8. Epub 2019 Feb 8.

1 Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.

Objective: Kidney stone formers are at risk for opioid dependence. The aim of this study is to describe opiate exposure and determine predictors of prolonged opiate use among kidney stone formers after surgery.

Materials And Methods: A retrospective review was performed among patients who underwent ureteroscopy for upper tract stone disease. Read More

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http://dx.doi.org/10.1089/end.2018.0796DOI Listing
February 2019
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Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada.

Background: The incidence of nephrolithiasis in children and adolescents is increasing and appears to double every 10 years. The most important role of the pediatric nephrologist is to diagnose and modify various metabolic and non-metabolic risk factors, as well as prevent long-term complications especially in the case of recurrent nephrolithiasis.

Objective: The purpose of this review is to summarize the existing literature on the etiology and management of pediatric nephrolithiasis. Read More

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http://dx.doi.org/10.1007/s00467-018-4179-9DOI Listing
January 2019
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Microbiome-metabolome reveals the contribution of gut-kidney axis on kidney disease.

J Transl Med 2019 Jan 3;17(1). Epub 2019 Jan 3.

School of Pharmacy, Faculty of Life Science & Medicine, Northwest University, No. 229 Taibai North Road, Xi'an, 710069, Shaanxi, China.

Dysbiosis represents changes in composition and structure of the gut microbiome community (microbiome), which may dictate the physiological phenotype (health or disease). Recent technological advances and efforts in metagenomic and metabolomic analyses have led to a dramatical growth in our understanding of microbiome, but still, the mechanisms underlying gut microbiome-host interactions in healthy or diseased state remain elusive and their elucidation is in infancy. Disruption of the normal gut microbiota may lead to intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1756-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317198PMC
January 2019
6 Reads
3.930 Impact Factor

Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate.

Free Radic Biol Med 2018 Dec 29;134:9-22. Epub 2018 Dec 29.

Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Hyperoxaluria induces oxidative stress, and inflammation causes renal epithelial cell injury in nephrolithiasis, suggesting that reduced oxalate toxicity may be beneficial. This study aimed to investigate whether nuclear factor (erythroid-derived 2)-like 2 (Nrf2, also called Nfe2l2) induced by dimethyl fumarate (DMF) could protect renal epithelial cells against oxalate-mediated injury both in vivo and in vitro. Glyoxylic acid monohydrate was intraperitoneally injected into Sprague-Dawley rats with or without intragastric administration of DMF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183157
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.033DOI Listing
December 2018
10 Reads
5.736 Impact Factor

Early Stone Manipulation in Urinary Tract Infection Associated with Obstructing Nephrolithiasis.

Case Rep Urol 2018 25;2018:2303492. Epub 2018 Nov 25.

Division of Urology, Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA.

A urinary tract infection (UTI) and sepsis secondary to an obstructing stone are one of the few true urological emergencies. The accepted management of infected ureteral stones includes emergent decompression of the collecting system as well as antibiotic therapy. Despite this, no consensus guidelines clarify the optimal time to undergo definitive stone management following decompression. Read More

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http://dx.doi.org/10.1155/2018/2303492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286750PMC
November 2018
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