22,588 results match your criteria Nephrolithiasis


[Mesalazine renal lithiasis.]

Arch Esp Urol 2020 Jul;73(6):561-564

Servicio de Medicina Digestiva. Hospital Universitario de la Ribera. Alzira. Valencia. España.

Mesalazine (5-aminosalicylic acid, 5-ASA),is an anti-inflammatory drug well-established as first-line treatment in the management of inflammatory bowel disease. Nephritic colic has been described as an uncommonside effect, but very few mesalazine nephrolithiasis have been published in the literature, probably due to its underdiagnosis for not using appropriate methodology for calculi analysis. We present two cases of lithiasis in patients treated with mesalazine at high dosage, an adverse effect to betaken into account as a drug lithiasis and which is not even mentioned in the patient information leaflet. Read More

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MiR-21 promotes calcium oxalate-induced renal tubular cell injury by targeting PPARA.

Am J Physiol Renal Physiol 2020 Jul 6. Epub 2020 Jul 6.

Department of Urology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, China.

Kidney stone disease is a crystal concretion formed in kidneys which has been associated with an increased risk of chronic kidney disease. MicroRNAs are functionally involved in kidney injury. Data mining using a microRNA array database suggested that miR-21 may be associated with calcium oxalate monohydrate (COM)-induced renal tubular cell injury. Read More

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http://dx.doi.org/10.1152/ajprenal.00132.2020DOI Listing

VIDEO VISITS AS A SUBSTITUTE FOR UROLOGICAL CLINIC VISITS.

Urology 2020 Jun 30. Epub 2020 Jun 30.

Department of Urology, Michigan Medicine; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor.

Objective: To evaluate whether video visits were being used as substitutes to clinic visits prior to COVID-19 at our institution's outpatient urology centers.

Methods: We reviewed 600 established patient video visits completed by 13 urology providers at a tertiary academic center in southeast Michigan. We compared these visits to a random, stratified sample of established patient clinic visits. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.080DOI Listing

Interstitial Cystitis or Painful Bladder Syndrome in a Premenopausal Female Precipitated by Oral Combined Contraceptives.

Cureus 2020 May 29;12(5):e8348. Epub 2020 May 29.

Clinical Sciences, University of Central Florida College of Medicine, Orlando, USA.

It has been well documented that female sex is a significant risk factor for the development of various autoimmune diseases. While the reason for this has been debated, one well-regarded theory is that increased estrogen and decreased testosterone play a role in this predisposition. Interstitial cystitis (IC), also known as painful bladder syndrome (PBS), is an autoimmune disorder that affects over nine million women in the United States. Read More

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http://dx.doi.org/10.7759/cureus.8348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325412PMC

Prediction of stone-free rates following extracorporeal shockwave lithotripsy in a contemporary cohort of patients with stone densities exceeding 1000 HU.

Scand J Urol 2020 Jun 29:1-5. Epub 2020 Jun 29.

Department of Urology, State University of Campinas, Unicamp, Campinas, Brazil.

Nephrolithiasis is a common urologic problem, and its incidence is increasing. Shockwave Lithotripsy (SWL) has better results for patients with stones < 1000 HU. We attempted to identify SWL stone-free (SF) predictors for > 1000 HU stones. Read More

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http://dx.doi.org/10.1080/21681805.2020.1782981DOI Listing

The interest of oral calcium loads test in the diagnosis and management of pediatric nephrolithiasis with hypercalciuria: Experience from a tertiary pediatric centre.

J Pediatr Urol 2020 May 30. Epub 2020 May 30.

Centre de Référence des Maladies Rénales Rares, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Centre de Référence des Maladies Rares Du Calcium et Du Phosphore, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France; Faculté de Médecine Lyon Est, Université Lyon 1, Lyon, France; INSERM 1033 Research Unit, Lyon, France. Electronic address:

Introduction: The use of calcium load has been forgotten in pediatrics until recently whereas it is of utmost importance to have a practical approach to guide management of hypercalciuric nephrolithiasis.

Objective: The purpose of this study was to evaluate the practical interest of oral calcium loads to improve the overall management of nephrolithiasis in children.

Methods: We retrospectively studied all pediatric patients having undergone an oral calcium load in our pediatric nephrology unit between September 2015 and April 2017. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.160DOI Listing

A Rare Case of T-Cell Lymphoma Presenting with Bilateral Nephrolithiasis and Acute Renal Failure.

Urology 2020 Jun 24. Epub 2020 Jun 24.

Department of Urology, University of Oklahoma HSC, Children's Hospital at OU Medical Center, Oklahoma City, OK. Electronic address:

We present the rare case of a young boy who was found to have T-cell lymphoma after presenting with flank pain and bilateral nephrolithiasis. He initially underwent bilateral ureteral stent placement but returned with oliguria and acute renal failure. His subsequent workup revealed lymphoma involving both kidneys. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.013DOI Listing

Urolithiasis in Children.

Adv Pediatr 2020 Aug 26;67:105-112. Epub 2020 May 26.

Department of Pediatrics, University of South Florida, 17 Davis Boulevard, Suite 200, Tampa, FL 33606, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yapd.2020.03.004DOI Listing

Letter to the Editor - Reply.

Urology 2020 Jun 23. Epub 2020 Jun 23.

Division of Urology, Duke University Medical Center. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2020.06.012DOI Listing

Association of chronic kidney disease stage with 24-hour urine values among patients with nephrolithiasis.

J Endourol 2020 Jun 24. Epub 2020 Jun 24.

Vanderbilt University Medical Center, 12328, Urology, 1161 21st Ave South, Nashville, Tennessee, United States, 37232;

Introduction Nephrolithiasis is a known risk factor for CKD however it is unknown how CKD affects urinary parameters related to stone risk. The purpose of this study was to assess the relationship of diminishing glomerular filtration rate (GFR) and kidney stone related 24-hour urine (24H urine) composition. Materials and Methods A single-institution retrospective review of patients (n=2,057) who underwent 24H urine analysis was performed. Read More

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http://dx.doi.org/10.1089/end.2020.0403DOI Listing

Seven cases of parathyroid carcinoma and review of the literature.

Hormones (Athens) 2020 Jun 23. Epub 2020 Jun 23.

Department of Endocrinology and Metabolism, Marmara University School of Medicine, Istanbul, Turkey.

Parathyroid cancer is a rare malignancy and an uncommon cause of hyperparathyroidism. In the present study, we present seven cases of parathyroid carcinoma. The female ratio was 5/7 (71. Read More

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http://dx.doi.org/10.1007/s42000-020-00220-yDOI Listing

Clinical-grade Garcinia cambogia extract dissolves calcium oxalate crystals in Drosophila kidney stone models.

Eur Rev Med Pharmacol Sci 2020 Jun;24(11):6434-6445

Division of Nephrology, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Diseases, Guangzhou, China.

Objective: Kidney stone formers have a high rate of stone recurrence after kidney stone removal surgery and there is no effective medication for treatment. Hydroxycitric acid (HCA), which is the major component of Garcinia cambogia extract, can dissolve calcium oxalate crystals in vitro, suggesting that Garcinia cambogia could be used to treat calcium oxalate kidney stone. In this study, we used the Drosophila kidney disease model to evaluate the effect of Garcinia cambogia on the prevention and removal of calcium oxalate stones in vivo. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21542DOI Listing

Nonalcoholic Fatty Liver Disease (NAFLD) is an Independent Risk Factor for Nephrolithiasis in Women: Findings from NHANES III.

J Endourol 2020 Jun 22. Epub 2020 Jun 22.

Albert Einstein Healthcare Network, 6528, Department of Urology, Philadelphia, Pennsylvania, United States.

Objective To determine if radiologically diagnosed nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for nephrolithiasis using data from National Health and Nutrition Examination Survey III (NHANES III). Patients and Methods NHANES III participants aged 20-74 years who underwent hepatobiliary ultrasound were classified as with NAFLD (moderate or severe hepatic steatosis in absence of other known causes of liver disease; n = 2,498) or without NAFLD (controls; n = 9,361). Risk of nephrolithiasis due to NAFLD was estimated using logistic regression with propensity score adjustment. Read More

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http://dx.doi.org/10.1089/end.2020.0486DOI Listing

The influence of dysbiosis on kidney stones that risk up renal cell carcinoma (RCC).

Semin Cancer Biol 2020 Jun 20. Epub 2020 Jun 20.

Department of Biotechnology, Himachal Pradesh University, Summer Hill, Shimla, 171 005 India. Electronic address:

Kidney stone is a common urological condition, the prevalence and incidence of which has escalated in the last few years due to dietary habits and other related medical conditions such as obesity and diabetes mellitus. It is a chronic disease which leads to loss of kidney function(s) and nephrectomy. Chronic kidney stone disease has been shown to be associated with transitional cell carcinoma (TCC) or renal cell carcinoma (RCC) and kidney tumors have been found to be more frequent among patients with kidney stones. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.06.011DOI Listing

Primary hyperoxaluria Type 1: A case report in an extended family with a novel AGXT gene mutation.

Medicine (Baltimore) 2020 Jun;99(25):e20371

Faculty of Medicine, Cairo University, Cairo, Egypt.

Introduction: Primary hyperoxaluria type 1 (PH1) is a genetic autosomal recessively inherited disorder due to mutation in the alanine-glyoxylate aminotransferase (AGXT) gene. It usually presents in children with nephrolithiasis and/or nephrocalcinosis and progressive renal function impairment and end stage renal disease (ESRD).

Patient Concerns: A 13 years old Saudi boy with history of recurrent urolithiasis since the age of 2 years presented to us with picture of ESRD. Read More

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http://dx.doi.org/10.1097/MD.0000000000020371DOI Listing

Metabolic risk factors in children with kidney stone disease: an update.

Pediatr Nephrol 2020 Jun 20. Epub 2020 Jun 20.

Instituto de Investigaciones Metabólicas (IDIM), Libertad 836, 1er piso (1012), Buenos Aires, Argentina.

Background: The prevalence of kidney stones in children has significantly increased in the past few decades, with concomitant increased morbidity and healthcare costs worldwide. Assessing metabolic risk factors is essential for diagnosis and specific treatment. The objective of this retrospective study is to identify the epidemiological and clinical characteristics of children under 17 years of age, as well as the metabolic risk factors of nephrolithiasis. Read More

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http://dx.doi.org/10.1007/s00467-020-04660-xDOI Listing

Racial Differences in Risk Factors for Kidney Stone Formation.

Clin J Am Soc Nephrol 2020 Jun 19. Epub 2020 Jun 19.

Department of Medicine, Section of Nephrology, University of Chicago, Chicago, Illinois.

Background And Objectives: Incidence of kidney stone disease is rising. It is not known whether mechanisms of stone formation differ across racial groups. Our objective was to identify differing lithogenic risk factors across racial groups in idiopathic nephrolithiasis. Read More

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http://dx.doi.org/10.2215/CJN.12671019DOI Listing

Characteristics of the genotype and phenotype in Chinese primary hyperoxaluria type 1 populations.

Urolithiasis 2020 Jun 18. Epub 2020 Jun 18.

Department of Urology, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, 100050, China.

The aim of our study is to explore the relationship between genotype and phenotype in Chinese PH1 patients and determine the putative mutation hotspot regions. This was a retrospective study regarding 13 Chinese PH1 patients. And all sporadic published researches of Chinese PH1 populations were searched and enrolled based on the inclusive standard. Read More

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http://dx.doi.org/10.1007/s00240-020-01201-xDOI Listing

Hypercalcemia in the Presence of an Ectopic Mediastinal Mass.

J Prim Care Community Health 2020 Jan-Dec;11:2150132720932411

Mayo Clinic, Rochester, MN, USA.

A 72-year-old gentleman who presented to the outpatient clinic for a preventive health appointment with symptoms of depression and fatigue was found to have persistent hypercalcemia on routine laboratory monitoring. Initial laboratory testing was consistent with primary hyperparathyroidism with elevation in parathyroid hormone and low vitamin D levels. Further imaging demonstrated an ectopic mediastinal parathyroid adenoma. Read More

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http://dx.doi.org/10.1177/2150132720932411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307481PMC

Uric acid and cardiometabolic diseases.

Clin Hypertens 2020 15;26:13. Epub 2020 Jun 15.

Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181 Republic of Korea.

Hyperuricemia, which has been considered as a cause of gout and nephrolithiasis has recently been suggested to be associated with hypertension, coronary heart disease, heart failure, atrial fibrillation, insulin resistance, and nonalcoholic fatty liver disease. Several clinical and experimental studies have supported uric acid (UA) as an independent risk factor for predicting disease development along with the traditional risk factors. The mechanism by which UA causes cardiometabolic disease has not been fully elucidated to date; however, it has been explained by several hypotheses such as oxidative stress, reduced nitric oxide bioavailability, inflammation, endothelial dysfunction, and so on. Read More

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http://dx.doi.org/10.1186/s40885-020-00146-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294650PMC

NEPHROLITHIASIS AND ELEVATED URINARY AMMONIUM: A MATCHED COMPARATIVE STUDY.

Urology 2020 Jun 13. Epub 2020 Jun 13.

Department of Urology, Vanderbilt University Medical Center, Nashville TN. Electronic address:

Objective: To describe the associations between elevated urinary ammonium and clinical characteristics of kidney stone formers. A 24-hour urine test is recommended in high-risk patients to identify urinary abnormalities and select interventions to reduce the recurrence risk. While elevations in urine ammonium may be seen in acidosis, diarrhea, high protein diets or due to pathogenic bacteria, the clinical characteristics of these patients has not been previously described. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.063DOI Listing

Understanding the relationship between health insurance and kidney stones: an examination of NHANES data.

Can J Urol 2020 Jun;27(3):10238-10243

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

Introduction: To investigate the relationship between socioeconomic factors, specifically insurance status, and kidney stones using a nationally representative cohort.

Materials And Methods: A retrospective secondary data analysis of National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2014 was performed. Using univariate statistics and multiple logistic regressions, we examined the relationship between socioeconomic factors and kidney stone history. Read More

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The Association Between 24-Hour Urine and Stone Recurrence Among High Risk Kidney Stone Formers: A Population Level Assessment.

Urology 2020 Jun 12. Epub 2020 Jun 12.

Department of Urology, University of Washington Medical Center, Seattle, WA. Electronic address:

Objectives: To determine if obtaining a 24-hour urine collection (24HU) in stone formers is associated with decreased recurrent stone episodes.

Methods: Using the MarketScan® database, adults 17-62 years old with nephrolithiasis were identified between 2007-2017 with a minimum of 3 years follow up. High-risk stone formers, those undergoing stone surgery, and those with history of recurrent stones were identified. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.064DOI Listing

Glycemic Status, Insulin Resistance, and the Risk of Nephrolithiasis: A Cohort Study.

Am J Kidney Dis 2020 Jun 10. Epub 2020 Jun 10.

Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. Electronic address:

Rationale & Objective: The effect of glycemic status on nephrolithiasis risk remains controversial. This study sought to examine the association of glycemic status and insulin resistance with incident nephrolithiasis.

Study Design: A retrospective cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.013DOI Listing

Genetics of kidney stone disease.

Nat Rev Urol 2020 Jul 12;17(7):407-421. Epub 2020 Jun 12.

Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Kidney stone disease (nephrolithiasis) is a common problem that can be associated with alterations in urinary solute composition including hypercalciuria. Studies suggest that the prevalence of monogenic kidney stone disorders, including renal tubular acidosis with deafness, Bartter syndrome, primary hyperoxaluria and cystinuria, in patients attending kidney stone clinics is ∼15%. However, for the majority of individuals, nephrolithiasis has a multifactorial aetiology involving genetic and environmental factors. Read More

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http://dx.doi.org/10.1038/s41585-020-0332-xDOI Listing

Otoconia degeneration as a consequence of primary hyperparathyroidism.

Med Hypotheses 2020 Jun 7;144:109982. Epub 2020 Jun 7.

Department of Surgery, Division of Otolaryngology, Head and Neck Surgery, University of Connecticut Health, 263 Farmington Avenue, Farmington, CT 06030, USA. Electronic address:

Primary hyperparathyroidism (PHPT) is a common endocrine condition which disrupts physiologic calcium regulation. PHPT causes persistent hypercalcemia via the elevated and constant secretion of parathyroid hormone. Due to the effects of parathyroid hormone on target organs such as the bones, kidneys and gastrointestinal tract, untreated PHPT can lead to complications such as decreased bone mineral density, nephrolithiasis, and chronic abdominal pain, respectively. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109982DOI Listing

Multidisciplinary management of adult cloacal exstrophy complications: A challenging case of nephrolithiasis and abdominal wall extrusion of a catheterizable ileal pouch.

Urol Case Rep 2020 Nov 19;33:101265. Epub 2020 May 19.

Department of Urology, Einstein Healthcare Network, Philadelphia, PA, 19141, USA.

Cloacal exstrophy is a rare congenital syndrome which comprises multiple genitourinary, gastrointestinal and musculoskeletal anomalies. The long-term effects following childhood cloacal exstrophy management is poorly characterized in living adults. In this report, a 42-year-old female born with cloacal exstrophy presented after numerous prior surgical reconstructions with abdominal extrusion of a catheterizable ileal pouch and bilateral staghorn calculi. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276429PMC
November 2020

ADPKD, Tolvaptan, and Nephrolithiasis Risk.

Clin J Am Soc Nephrol 2020 Jun 11. Epub 2020 Jun 11.

Division of Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.2215/CJN.07610520DOI Listing

Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan.

Clin J Am Soc Nephrol 2020 Jun 11. Epub 2020 Jun 11.

Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Background And Objectives: Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity. Recently, Tolvaptan has been introduced for the treatment of ADPKD, but whether it is associated with alterations of the urinary lithogenic risk profile remains unknown.

Design, Setting, Participants, & Measurements: We conducted an analysis of participants enrolled in the Bern ADPKD registry, a prospective observational cohort study. Read More

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http://dx.doi.org/10.2215/CJN.13861119DOI Listing

Associations between nephrolithiasis and diabetes mellitus, hypertension and gallstones: A meta-analysis of cohort studies.

Nephrology (Carlton) 2020 Jun 11:e13740. Epub 2020 Jun 11.

Department of Urology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Aim: To review and clarify the strengths and directions of associations between nephrolithiasis and hypertension (HTN), diabetes mellitus (DM) and gallstones (GS) given the inconsistent results reported in cohort studies.

Methods: Relevant literature was searched in PubMed and EMBASE from inception to July 2019, for cohort studies that examined the relationships between kidney stones and these three diseases among adults. Pooled relative risks (RRs) were calculated by maximally adjusted risk estimates using a random effect model. Read More

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http://dx.doi.org/10.1111/nep.13740DOI Listing

Obesity and Kidney Stone Procedures.

Rev Urol 2020 ;22(1):24-29

Department of Urology, University of Alabama-Birmingham Birmingham, AL.

Obesity is a chronic disease that has increased in prevalence in the United States and is a risk factor for the development of nephrolithiasis. As with other medical conditions, obesity should be considered when optimizing surgical management and choosing kidney stone procedures for patients. In this review, we outline the various procedures available for treating stone disease and discuss any discrepancies in outcomes or complications for the obese cohort. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265183PMC
January 2020

Pediatric Nephrolithiasis: Risk Factors, Evaluation, and Prevention.

Authors:
Sermin A Saadeh

Pediatr Ann 2020 Jun;49(6):e262-e267

Pediatric nephrolithiasis is a disease of increasing prevalence and economic burden, with data showing a rising trend among girls and adolescents. Kidney stones in children tend to have a high recurrence rate related to underlying risk factors, and the aim of evaluation should be to understand such causes so that targeted therapy can be provided to decrease recurrence and complications. Metabolic, anatomic, and genetic abnormalities as well as environmental risk factors have all been implicated in the pathogenesis of nephrolithiasis. Read More

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http://dx.doi.org/10.3928/19382359-20200518-01DOI Listing

Tissue-engineered Parathyroid Gland and Its Regulatory Secretion of Parathyroid Hormone.

J Tissue Eng Regen Med 2020 Jun 8. Epub 2020 Jun 8.

Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, R.P. China.

Parathyroid glands (PTGs) are important endocrine organs being mainly responsible for the secretion of parathyroid hormone (PTH) to regulate the balance of calcium (Ca) /phosphorus (P) ions in the body. Once PTGs get injured or removed, their resulting defect or loss of PTH secretion should disturb the level of Ca/P in blood, thus damaging other related organs (bone, kidney, etc.) and even causing death. Read More

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http://dx.doi.org/10.1002/term.3080DOI Listing

iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol.

Biomed Res Int 2020 15;2020:6137947. Epub 2020 May 15.

Department of Urology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China 410011., China.

Nephrolithiasis is a frequent chronic urological condition with a high prevalence and recurrence rate. Proteomics studies on urolithiasis rat models are highly important in characterizing the pathophysiology of kidney stones and identifying potential approaches for preventing and treating kidney stones. The isobaric tags for relative and absolute quantification (iTRAQ) were performed to identify differentially expressed proteins (DEPs) in the kidney between urolithiasis rats and control rats. Read More

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http://dx.doi.org/10.1155/2020/6137947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246402PMC

Association between sex hormones and kidney stones: analysis of the National Health and Nutrition Examination Survey.

World J Urol 2020 Jun 5. Epub 2020 Jun 5.

Department of Urology, University of Miami, Miami, FL, USA.

Purpose: Increasing age, male gender, and metabolic syndrome are associated with kidney stone formation. As sex hormones change with age, gender, and metabolic syndrome, we hypothesized that sex hormones may underlie the physiologic changes affecting stone formation.

Methods: We analyzed the relationships between testosterone, estradiol, and history of kidney stones using data from 10,193 participants in the Continuous National Health and Nutrition Examination Survey (NHANES) database from 2013-2016. Read More

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http://dx.doi.org/10.1007/s00345-020-03286-wDOI Listing
June 2020
2.666 Impact Factor

The gut microbiota profile of adults with kidney disease and kidney stones: a systematic review of the literature.

BMC Nephrol 2020 Jun 5;21(1):215. Epub 2020 Jun 5.

University of Wollongong, School of Medicine, Faculty of Science, Medicine and Health, Wollongong, New South Wales, 2522, Australia.

Background: There is mounting evidence that individuals with kidney disease and kidney stones have an abnormal gut microbiota composition. No studies to date have summarised the evidence to categorise how the gut microbiota profile of these individuals may differ from controls. Synthesis of this evidence is essential to inform future clinical trials. Read More

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http://dx.doi.org/10.1186/s12882-020-01805-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275316PMC

A rare cause of nephrocalcinosis in an infant: Answers.

Pediatr Nephrol 2020 Jun 4. Epub 2020 Jun 4.

Pediatric Gastroenterology, Hepatology and Nutrition Unit, Division of Pediatrics, Hospital Regional Universitario de Málaga, Málaga, Spain.

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http://dx.doi.org/10.1007/s00467-020-04615-2DOI Listing

Dietary pattern analysis among stone formers: resemblance to a DASH-style diet.

J Bras Nefrol 2020 Jun 1. Epub 2020 Jun 1.

Universidade Federal de São Paulo, Programa de Nutrição, São Paulo, Brasil.

Recent epidemiological studies have shown that dietary patterns may have a more persistent impact on the risk of stone formation than single nutrients of the diet. Dietary Approaches to Stop Hypertension (DASH), a low-sodium and fruits/vegetables-rich diet, has been associated with a lower risk of nephrolithiasis, due to altered urinary biochemistry. This observational study aimed to investigate whether the dietary pattern of stone formers (SF) resembled a DASH-diet and its influence on urinary lithogenic parameters. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0183DOI Listing

Back pain "red flags": which are most predictive of serious pathology in the Emergency Department?

Eur Spine J 2020 Jun 3. Epub 2020 Jun 3.

La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Melbourne, Australia.

Purpose: To determine the frequency of red flag signs and symptoms in patients presenting with back pain to the Emergency Department (ED) and association with serious pathologies and investigations performed.

Methods: This retrospective observational study evaluated consecutive patients presenting with back pain to a Melbourne ED over a 14-month period. Data regarding red flags, patient characteristics, ED-initiated investigations, and diagnoses were extracted from medical records. Read More

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http://dx.doi.org/10.1007/s00586-020-06452-1DOI Listing

Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study.

BMC Endocr Disord 2020 Jun 3;20(1):79. Epub 2020 Jun 3.

Institute and department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No.639 Zhizaoju Road, Shanghai, China.

Background: Uric acid (UA) is the end product of purine metabolism, which is thought to be related to many human diseases, such as nephrolithiasis, gout, cardiovascular disease (CVD), type 2 diabetes mellitus, metabolic syndrome. However, the relationship between serum UA (SUA) and 25(OH) D is still unclear in the eastern Chinese population.

Methods: We did a population-based observational investigation, which included 12,770 residents living in eastern China. Read More

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http://dx.doi.org/10.1186/s12902-020-00560-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268462PMC

Formulation, Optimization, and Evaluation of Allopurinol-Loaded Bovine Serum Albumin Nanoparticles for Targeting Kidney in Management of Hyperuricemic Nephrolithiasis : Formulation, optimization, and evaluation of ABNPs for kidney targeting.

AAPS PharmSciTech 2020 Jun 2;21(5):164. Epub 2020 Jun 2.

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India.

The aim of present research work was to design, fabricate, optimize, and evaluate allopurinol (ALLO)-loaded bovine serum albumin nanoparticles (ABNPs) for kidney targeting of the drug and exploring the potential of fabricated ABNPs for management of hyperuricemia-related nephrolithiasis. ABNP formulation was prepared by employing desolvation technique, and its optimization was conducted by 2-factor-3-level central composite design (CCD) in order to achieve minimum particle size (PSA) and polydispersity index (PDI), maximum entrapment efficiency (EE), and zeta potential (ZP). Further, the optimized formulation (ABNPs) was also assessed for in vitro drug release study, TEM, DSC, XRD analysis, FTIR spectroscopy, and in vivo animal study. Read More

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http://dx.doi.org/10.1208/s12249-020-01695-zDOI Listing
June 2020
1.776 Impact Factor

Association of simple renal cysts and chronic kidney disease with large abdominal aortic aneurysm.

BMC Nephrol 2020 May 29;21(1):201. Epub 2020 May 29.

Vascular Surgery Clinic, Klinik für Gefäßchirurgie, Campus Charité Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany.

Background: Abdominal aortic aneurysms (AAA) primarily affect men over 65 years old who often have many other diseases, with similar risk factors and pathobiological mechanisms to AAA. The aim of this study was to assess the prevalence of simple renal cysts (SRC), chronic kidney disease (CKD), and other kidney diseases (e.g. Read More

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http://dx.doi.org/10.1186/s12882-020-01841-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257207PMC

Macrohematuria during diabetic ketoacidosis at onset of type 1 diabetes: a case report of nephrolithiasis.

Acta Diabetol 2020 May 28. Epub 2020 May 28.

Department of Pediatrics, Santa Maria delle Croci Hospital, Ravenna, Italy.

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http://dx.doi.org/10.1007/s00592-020-01545-1DOI Listing
May 2020
2.399 Impact Factor

Characterization of intracalyceal pressure during ureteroscopy.

World J Urol 2020 May 27. Epub 2020 May 27.

Department of Urology, University of California, 333 City Blvd. West, Suite 2100, Irvine, Orange, CA, 92868, USA.

Purpose: To provide the first report of measuring intracalyceal pressures during ureteroscopy (URS).

Methods: A prospective single-center clinical study using a cardiac pressure guidewire to measure intracalyceal pressure during flexible URS was performed. Eight patients (45 calyces) undergoing URS for nephrolithiasis were included. Read More

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http://dx.doi.org/10.1007/s00345-020-03259-zDOI Listing

Kidney stones: KI at the crossroads of nephrology and urology.

Kidney Int 2020 Jun;97(6):1070-1073

Department of Medicine, Division of Nephrology, Duke University and Duke Clinical Research Institute, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2020.03.019DOI Listing

[Argentine Intersociety Consensus on Urinary Infection 2018-2019 - Part II].

Medicina (B Aires) 2020 ;80(3):241-247

Sociedad Argentina de Infectología, Argentina.

The second part of the Inter-Society Argentine Consensus on Urinary Tract Infection (UTI) includes the analysis of special situations. In patients with urinary catheter, urine culture should be requested only in the presence of UTI symptomatology, before instrumentation of the urinary tract, or as a post-transplant control. The antibiotics recommended for empirical treatment in patients without risk factors are third-generation cephalosporins or aminoglycosides. Read More

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June 2020
0.421 Impact Factor

How does the COVID-19 pandemic affect the preoperative evaluation and anesthesia applied for urinary stones? EULIS eCORE-IAU multicenter collaborative cohort study.

Urolithiasis 2020 Aug 20;48(4):345-351. Epub 2020 May 20.

Department of Urology, School of Medicine, Medicana Bahcelievler Hospital, Biruni University, Istanbul, Turkey.

Stone disease is a unique condition that requires appropriate management in a timely manner as it can result in both emergent conditions and long term effects on kidney functions. In this study it is aimed to identify the up-to-date practice patterns related to preoperative evaluation and anesthesia for stone disease interventions during COVID-19 pandemic. The data of 473 patients from 11 centers in 5 different countries underwent interventions for urinary stones during the Covid-19 pandemic was collected and analyzed retrospectively. Read More

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http://dx.doi.org/10.1007/s00240-020-01193-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239347PMC

Dietary Recommendations for Bariatric Patients to Prevent Kidney Stone Formation.

Nutrients 2020 May 16;12(5). Epub 2020 May 16.

Nephrology Division, Universidade Federal de São Paulo, São Paulo 04023-062, Brazil.

Bariatric surgery (BS) is one of the most common and efficient surgical procedures for sustained weight loss but is associated with long-term complications such as nutritional deficiencies, biliary lithiasis, disturbances in bone and mineral metabolism and an increased risk of nephrolithiasis, attributed to urinary metabolic changes resultant from low urinary volume, hypocitraturia and hyperoxaluria. The underlying mechanisms responsible for hyperoxaluria, the most common among all metabolic disturbances, may comprise increased intestinal oxalate absorption consequent to decreased calcium intake or increased dietary oxalate, changes in the gut microbiota, fat malabsorption and altered intestinal oxalate transport. In the current review, the authors present a mechanistic overview of changes found after BS and propose dietary recommendations to prevent the risk of urinary stone formation, focusing on the role of dietary oxalate, calcium, citrate, potassium, protein, fat, sodium, probiotics, vitamins D, C, B6 and the consumption of fluids. Read More

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http://dx.doi.org/10.3390/nu12051442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284744PMC

Lithotriptic effect of Safūf Hajar-al Yahūd in patients of Hasat-ul Kilya (Nephrolithiasis) - an open prospective clinical validation trial.

J Complement Integr Med 2020 May 19. Epub 2020 May 19.

Central Council for Research in Unani Medicine, New Delhi, Ministry of AYUSH, Govt of India, India.

Background Hasat-ul Kilya (Nephrolithiasis) is one of the most common chronic conditions and has been known to the mankind since antiquity. The incidence is increasing globally with geographic, racial and gender variation in its occurrence. Medical management of Nephrolithiasis still poses a considerable challenge for modern medical practice. Read More

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http://dx.doi.org/10.1515/jcim-2019-0301DOI Listing