21,617 results match your criteria Nephrolithiasis


Selective protein enrichment in calcium oxalate stone matrix: a window to pathogenesis?

Urolithiasis 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine/Division of Nephrology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI, 53226, USA.

Urine proteins are thought to control calcium oxalate stone formation, but over 1000 proteins have been reported in stone matrix obscuring their relative importance. Proteins critical to stone formation should be present at increased relative abundance in stone matrix compared to urine, so quantitative protein distribution data were obtained for stone matrix compared to prior urine proteome data. Matrix proteins were isolated from eight stones (> 90% calcium oxalate content) by crystal dissolution and further purified by ultradiafiltration (> 10 kDa membrane). Read More

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http://link.springer.com/10.1007/s00240-019-01131-3
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http://dx.doi.org/10.1007/s00240-019-01131-3DOI Listing
April 2019
1 Read

A Twin Study of Genetic Influences on Nephrolithiasis in Women and Men.

Kidney Int Rep 2019 Apr 29;4(4):535-540. Epub 2018 Nov 29.

Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Background: Nephrolithiasis is a complex phenotype influenced by both genetic and environmental factors. Previously we found a genetic component to stone disease using a sample of male twin pairs. We now report on the genetic contribution to stones in a sample of female and male twin pairs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249183031
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http://dx.doi.org/10.1016/j.ekir.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451147PMC
April 2019
1 Read

Oxygen Venous Embolism After Hydrogen Peroxide Use During Percutaneous Nephrolithotomy.

J Endourol Case Rep 2019 18;5(1):25-27. Epub 2019 Mar 18.

Department of Urology, George Washington University Medical School, Washington, District of Columbia.

Hydrogen peroxide (HO) is a common antiseptic that is available without a prescription in the United States, and it is indicated for minor dermal abrasion; mouth, gum, or dental irritations; and removal of oral secretion. Several other medical uses have also been described, including clot dissolution during endoscopic gastrointestinal evaluation, cleansing of orthopedic surgical sites, and bladder irrigation. However, these uses of HO, as well as high-dose ingestion, have been associated with a wide variety of medical complications, including but not limited to air pulmonary embolism and stroke. Read More

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https://www.liebertpub.com/doi/10.1089/cren.2018.0111
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http://dx.doi.org/10.1089/cren.2018.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461058PMC
March 2019
1 Read

Clinicopathological Spectrum of Xanthogranulomatous Pyelonephritis.

Indian J Nephrol 2019 Mar-Apr;29(2):111-115

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Xanthogranulomatous pyelonephritis (XGP) is an uncommon and distinct type of chronic infective pyelonephritis causing destruction of the kidney, severely affecting the renal function. The perinephric adipose tissue and peritoneum is not uncommonly involved. The study was undertaken to decipher the clinicopathologic spectrum of XGP. Read More

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http://dx.doi.org/10.4103/ijn.IJN_50_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440323PMC

[Modern nephrolithiasis in the complex setting of metaphylaxis : Latest epidemiological data and a nationwide survey in private practices].

Urologe A 2019 Apr 12. Epub 2019 Apr 12.

Klinik und Poliklinik für Urologie, Universitätsklinikum, Friedrich-Schiller-Universität Jena, Jena, Deutschland.

The focus of this work is on aspects of the current management of recurrent nephrolithiasis in private practices and outpatient departments in Germany. We wanted to make a contribution to the epidemiological discourse as well as for an instrument for the self-reflection and complex classification of urolithiasis in everyday practice by a first-time determination of population-based, age- and gender-based data based on the full recording of urological diagnoses and treatments in the federal accounting setting. The analysis of the taken positions in this representative practice survey prove to some extent information and experience deficits in the handling of complicated nephrolithiasis. Read More

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http://link.springer.com/10.1007/s00120-019-0927-0
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http://dx.doi.org/10.1007/s00120-019-0927-0DOI Listing
April 2019
2 Reads

Radiation Dose Reduction of Unenhanced CT Limited to the Kidneys for Follow-Up of Patients With Known Nephrolithiasis Without Symptoms.

AJR Am J Roentgenol 2019 Apr 11:1-4. Epub 2019 Apr 11.

1 Department of Radiology, University of California, Davis, 4860 Y St, Ste 3100, Sacramento, CA 95817.

Objective: The purpose of this study is to identify the landmarks and associated radiation dose reduction for limited CT of the kidneys of patients requiring follow-up for known nephrolithiasis.

Materials And Methods: This retrospective study included all adult patients who underwent CT examination type "CT abdomen + pelvis renal stone" at our institution during 2017. Several exclusion criteria were identified, including scoliosis and congenital renal abnormalities. Read More

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http://dx.doi.org/10.2214/AJR.18.20805DOI Listing
April 2019
4 Reads

Structural characterization and screening of chemical markers of flavonoids in Lysimachiae Herba and Desmodii Styracifolii Herba by ultra high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry based metabolomics approach.

J Pharm Biomed Anal 2019 Apr 3;171:52-64. Epub 2019 Apr 3.

Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang, Hebei 050017, PR China. Electronic address:

In traditional Chinese medicine, Lysimachiae Herba (LH) and Desmodii Styracifolii Herba (DSH) have been widely used for the treatment of calculi, but there is a certain focus in clinical application. Flavonoids as their pharmacologically active substances were focusly studied to make clear of their chemical compositions and reveal the similarities and differences between LH and DHS by analysis of characteristic marker components at the molecular level. An ultra high performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-MS/MS) approach based on metabolite profiling was established. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.003DOI Listing
April 2019
2 Reads

Assessing Cost-Effectiveness of New Technologies in Stone Management.

Urol Clin North Am 2019 May 4;46(2):303-313. Epub 2019 Mar 4.

Urology, University of California San Francisco, San Francisco, CA, USA.

Diagnosis, treatment, and follow-up are all influential in determining the overall cost to the health care system for kidney stones. New innovations in the field of nephrolithiasis have been abundant, including disposable ureteroscopes, ultrasound-guided approaches to percutaneous nephrolithotomy, and advanced laser lithotripters. Identifying cost-effective treatment strategies encourages practitioners to be thoughtful about providing value-based high-quality care and remains on important principle in the treatment of urinary stone disease. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.011DOI Listing
May 2019
1 Read

Emerging Mobile Platforms to Aid in Stone Management.

Urol Clin North Am 2019 May 4;46(2):287-301. Epub 2019 Mar 4.

Department of Urology, Columbia University Medical Center, New York Presbyterian Hospital, 161 Fort Washington Avenue, 11th Floor, New York, NY 10032, USA. Electronic address:

Nephrolithiasis is an increasingly common condition worldwide and mobile technology is revolutionizing how patients with kidney stone are being diagnosed and managed. Emerging platforms include software applications to increase adherence to stone prevention, mobile compatible hardware, online social media communities, and telemedicine. Applications and hardware specifically relevant to increasing hydration, diet modification, medication adherence, and rapid diagnosis (ie, mobile ultrasound and endoscopy) have the greatest potential to reduce stone recurrence and expedite treatment. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.010DOI Listing
May 2019
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Innovations in Ultrasound Technology in the Management of Kidney Stones.

Urol Clin North Am 2019 May 4;46(2):273-285. Epub 2019 Mar 4.

Department of Urology, University of Washington School of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356510, Seattle, WA 98195, USA.

This article reviews new advances in ultrasound technology for urinary stone disease. Recent research to facilitate the diagnosis of nephrolithiasis, including use of the twinkling signal and posterior acoustic shadow, have helped to improve the use of ultrasound examination for detecting and sizing renal stones. New therapeutic applications of ultrasound technology for stone disease have emerged, including ultrasonic propulsion to reposition stones and burst wave lithotripsy to fragment stones noninvasively. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461360PMC
May 2019
1 Read

Radiation Mitigation Techniques in Kidney Stone Management.

Urol Clin North Am 2019 May 4;46(2):265-272. Epub 2019 Mar 4.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Patients with nephrolithiasis are exposed to significant quantities of ionizing radiation with the potential to cause secondary malignancy. This risk is magnified by the high recurrence rate of nephrolithiasis. In this article, we identify the risks of ionizing radiation as they pertain to patients with nephrolithiasis. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.008DOI Listing
May 2019
2 Reads

New Technologies to Aid in Percutaneous Access.

Urol Clin North Am 2019 May;46(2):225-243

Department of Urology, Loma Linda University Health, Loma Linda University Medical Center, 11234 Anderson Street, Room A560, Loma Linda, CA 92354, USA. Electronic address:

Although advances in percutaneous nephrolithotomy have occurred, the initial renal access remains a challenging and high-risk step. This risk and technical difficulty have resulted in a minority of urologists obtaining their own access. Therefore, continued innovation in access techniques that simplify the procedure, lower risk, and reduce radiation exposure is needed. Read More

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http://dx.doi.org/10.1016/j.ucl.2019.01.001DOI Listing
May 2019
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Emerging Technologies in Lithotripsy.

Urol Clin North Am 2019 May 4;46(2):215-223. Epub 2019 Mar 4.

Department of Urology, Indiana University, Methodist Hospital, 1801 Senate Boulevard, Suite 220, Indianapolis, IN 46202, USA. Electronic address:

This comprehensive review updates the advances in extracorporeal lithotripsy, including improvements in external shockwave lithotripsy and innovations in ultrasound based lithotripsy, such as burst wave lithotripsy, ultrasonic propulsion, and histotripsy. Advances in endoscopic technology and training have changed the surgical approach to nephrolithiasis; however, improvements and innovations in extracorporeal lithotripsy maintain its status as an excellent option in appropriately selected patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00940143183019
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http://dx.doi.org/10.1016/j.ucl.2018.12.012DOI Listing
May 2019
2 Reads

Emerging Laser Techniques for the Management of Stones.

Urol Clin North Am 2019 May 4;46(2):193-205. Epub 2019 Mar 4.

Department of Urology, University of Michigan, NCRC Building 16, Room 114W, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.

Next-generation holmium laser systems provide the user with a range of parameters that can help optimize fragmentation efficiency. Ureteroscopic strategies broadly consist of fragmentation with active retrieval, or dusting, which uses low pulse energy settings to break stones into fine fragments for spontaneous passage. Techniques for dusting include dancing, chipping, and popcorning. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.005DOI Listing
May 2019
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Innovations in Disposable Technologies for Stone Management.

Urol Clin North Am 2019 May;46(2):175-184

Department of Urology, University of Minnesota, 420 Delaware Street SE, MMC 394 Mayo, Minneapolis, MN 55455, USA. Electronic address:

Disposable stone retrieval devices are an inherent element of modern-day stone management. Efforts are being made in several different areas to improve the efficiency of stone removal. Ureteral access sheaths with pressure control features as well as suction capabilities are being explored as one such mechanism. Read More

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http://dx.doi.org/10.1016/j.ucl.2018.12.003DOI Listing
May 2019
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Complications Encountered with Non-adherence to Regular Follow-up in the Long-term Medical Management of Hyperparathyroidism.

Cureus 2019 Jan 26;11(1):e3966. Epub 2019 Jan 26.

Internal Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, USA.

Primary hyperparathyroidism is the third most commonly encountered endocrine disorder after diabetes and thyroid diseases. There has been a constant debate between medical and surgical management of the disorder. Guidelines clearly indicate surgical management over medical management in symptomatic patients and asymptomatic patients below 50 years of age. Read More

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http://dx.doi.org/10.7759/cureus.3966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436886PMC
January 2019
1 Read

Stiripentol protects against calcium oxalate nephrolithiasis and ethylene glycol poisoning.

J Clin Invest 2019 Apr 4;130. Epub 2019 Apr 4.

Increased urinary oxalate excretion (hyperoxaluria) promotes the formation of calcium oxalate crystals. Monogenic diseases due to hepatic enzymes deficiency result in chronic hyperoxaluria, promoting end-stage renal disease in children and young adults. Ethylene glycol poisoning also results in hyperoxaluria promoting acute renal failure and frequently death. Read More

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http://dx.doi.org/10.1172/JCI99822DOI Listing
April 2019
4 Reads

Re: Urine Proteomic Profiling in Patients with Nephrolithiasis and Cystinuria.

Authors:
Dean G Assimos

J Urol 2019 Apr 1:101097JU0000000000000265. Epub 2019 Apr 1.

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http://dx.doi.org/10.1097/JU.0000000000000265DOI Listing
April 2019
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Predictors of nephrolithiasis, osteoporosis and mortality in primary hyperparathyroidism.

J Clin Endocrinol Metab 2019 Mar 27. Epub 2019 Mar 27.

Edinburgh Centre for Endocrinology and Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK.

Context: Primary Hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with an increased risk of cardiovascular disease and mortality. Read More

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http://dx.doi.org/10.1210/jc.2018-02483DOI Listing
March 2019
2 Reads

[Accidentally diagnosed distal renal tubular acidosis with nephrocalcinosis - a case report].

Pol Merkur Lekarski 2019 Mar;46(273):146-148

Medical University of Warsaw, Poland: Department of Pediatrics and Nephrology.

Distal renal tubular acidosis is a defect of acidification of urine in distal tubule. Full-blown form is characterized by polyuria, growth deficiency, nephrolithiasis or nephrocalcinosis. Mutations in genes encoding Cl-/HCO3 - exchanger (autosomal dominant) or H+-ATPase (autosomal recessive) are the most frequent in children. Read More

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March 2019
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Long-Term Adherence to Medications in Secondary Prevention of Urinary Tract Stones.

J Endourol 2019 Mar 26. Epub 2019 Mar 26.

Rabin medical center, urology , Keren kayemet st , Petach Tikva, Israel , 65222 ;

Purpose: To reduce the high recurrence rate of nephrolithiasis, patients are routinely prescribed secondary chemoprevention therapy with alkali citrate (Alkasolve® , Sam-On Ltd., Israel) for uric acid stones and hypocitraturia or Hydrochlorthiazide (Disothiazide®; Dexcel Ltd., Israel) for hypercalciuria. Read More

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http://dx.doi.org/10.1089/end.2019.0040DOI Listing
March 2019
1 Read

Complete Ultrasound-guided Percutaneous Nephrolithotomy in Prone and Supine Positions: A Randomized Controlled Study.

Urology 2019 Mar 19. Epub 2019 Mar 19.

Department of Urology, Benha University Hospital, Egypt.

Objectives: To evaluate the safety, efficacy, adverse events, and feasibility of ultrasound guided percutaneous nephrolithotomy (US-PCNL) in the management of large renal stones in supine and prone positions and to point out the practical considerations related to these techniques in comparison with standard PCNL.

Patients And Methods: This study was conducted between August 2013 to September 2018 as a prospective randomized and controlled study. A total of 392 consecutive patients with nephrolithiasis >2 cm were randomly assigned to undergo ultrasound PCNL in prone (P-US-PCNL) (132 patients); supine position (S-US-PCNL) (129 patients) or conventional PCNL (C-PCNL) (131 patients). Read More

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http://dx.doi.org/10.1016/j.urology.2019.03.004DOI Listing
March 2019
4 Reads

Staging a great escape -Incidentally detected renal urothelial carcinoma with extensive squamous metaplasia presenting as pyonephrosis.

J Cancer Res Ther 2019 Mar;15(Supplement):S159-S162

Department of Surgery, Maulana Azad Medical College, New Delhi, India.

Incidentally, detected upper urinary tract urothelial carcinoma is a rare entity. We report the case of a 70-year-old female patient who presented with flank pain, pyuria, fever, and a unilateral nonfunctioning kidney with nephrolithiasis and pyonephrosis on pyelography. Routine imaging failed to identify a mass lesion. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_628_17DOI Listing
March 2019
1 Read

Sex differences in the temperature dependence of kidney stone presentations: a population-based aggregated case-crossover study.

Urolithiasis 2019 Mar 21. Epub 2019 Mar 21.

Center for Pediatric Clinical Effectiveness, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.

Previous studies assumed a uniform relationship between heat and kidney stone presentations. Determining whether sex and other characteristics modify the temperature dependence of kidney stone presentations has implications for explaining differences in nephrolithiasis prevalence and improving projections of the effect of climate change on nephrolithiasis. We performed an aggregated case-crossover study among 132,597 children and adults who presented with nephrolithiasis to 68 emergency departments throughout South Carolina from 1997 to 2015. Read More

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http://dx.doi.org/10.1007/s00240-019-01129-xDOI Listing
March 2019
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The efficacy of flexible ureteroscopy lithotripsy and miniaturized percutaneous nephrolithotomy for the treatment of renal and proximal ureteral calculi of ≤2 cm: A retrospective study.

Medicine (Baltimore) 2019 Mar;98(11):e14535

Peking University China-Japan Friendship School of Clinical Medicine.

To assess the clinical effect of miniaturized percutaneous nephrolithotomy (MPCNL) and flexible ureteroscopy lithotripsy (FURL) for the treatment of renal and proximal ureteral calculi of ≤2 cm.A retrospective analysis was carried out on clinical data of 106 patients with kidney or upper urethral calculi. Among these patients, 58 underwent the MPCNL, and 48 received FURL. Read More

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http://dx.doi.org/10.1097/MD.0000000000014535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426591PMC
March 2019
3 Reads

Percutaneous Nephrolithotomy Access: A Systematic Review of Intraoperative Assistive Technologies.

J Endourol 2019 Apr 16. Epub 2019 Apr 16.

3 Division of Urology, University of Montreal Health Center (CHUM), Montreal, Canada.

Percutaneous nephrolithotomy (PCNL) is the current gold standard for the treatment of large and complex renal stone disease. It is a complex procedure that requires skill and experience. The most challenging step and key requisite of a successful PCNL is establishing optimal access to the renal collecting system with imaging modalities. Read More

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http://dx.doi.org/10.1089/end.2019.0085DOI Listing
April 2019
1 Read

External validation of the ROKS nomogram in a surgical cohort.

J Endourol 2019 Mar 18. Epub 2019 Mar 18.

1685 Highland AveMadison, Wisconsin, United States , 53705 ;

Objective: To assess the performance of Recurrence of Kidney Stone (ROKS) nomogram in identifying first-time stone formers who will require future stone procedures.

Methods: From January 2009 to February 2016, 2287 patients underwent surgical treatment for nephrolithiasis at our institution and 498 of them were eligible for this study. We defined recurrence as repeat surgery for symptomatic nephrolithiasis. Read More

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http://dx.doi.org/10.1089/end.2018.0893DOI Listing
March 2019
1 Read

A human proximal tubule-on-a-chip to study renal disease and toxicity.

Biomicrofluidics 2019 Jan 1;13(1):014107. Epub 2019 Feb 1.

Department of Biomedical Engineering, Binghamton University, Binghamton, New York 13902, USA.

Renal disease is a global problem with unsustainable health-care costs. There currently exists a lack of accurate human renal disease models that take into account the complex microenvironment of these tissues. Here, we present a reusable microfluidic model of the human proximal tubule and glomerulus, which allows for the growth of renal epithelial cells in a variety of conditions that are representative of renal disease states including altered glomerular filtration rate, hyperglycemia, nephrolithiasis, and drug-induced nephrotoxicity (cisplatin and cyclosporine). Read More

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http://dx.doi.org/10.1063/1.5083138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404920PMC
January 2019
3 Reads

Low Income and Nonwhite Race Are Strongly Associated with Worse Quality of Life in Patients with Nephrolithiasis.

J Urol 2019 Mar 13:101097JU0000000000000233. Epub 2019 Mar 13.

University of California-San Francisco , San Francisco , California.

Purpose: Kidney stones are a source of significant morbidity which have been shown to negatively impact health related quality of life. We sought to understand the association between health related quality of life, socioeconomic status and race among patients with kidney stones.

Materials And Methods: Patients with stones at a total of 11 stone centers across the United States completed the WISQOL (Wisconsin Stone Quality of Life) questionnaire. Read More

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http://dx.doi.org/10.1097/JU.0000000000000233DOI Listing
March 2019
5 Reads

Re: Prevalence of Nephrolithiasis in Patients with Chronic Liver Disease: A Case-Control Study.

Authors:
Dean G Assimos

J Urol 2019 Mar 13:10109701JU000055465016930bf. Epub 2019 Mar 13.

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http://dx.doi.org/10.1097/01.JU.0000554650.16930.bfDOI Listing
March 2019
1 Read

Sex-independent expression of chloride/formate exchanger Cfex (Slc26a6) in rat pancreas, small intestine, and liver, and male-dominant expression in kidneys.

Arh Hig Rada Toksikol 2018 Dec;69(4):286-303

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Chloride/formate exchanger (CFEX; SLC26A6) mediates oxalate transport in various mammalian organs. Studies in Cfex knockout mice indicated its possible role in development of male-dominant hyperoxaluria and oxalate urolithiasis. Rats provide an important model for studying this pathophysiological condition, but data on Cfex (rCfex) localisation and regulation in their organs are limited. Read More

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http://dx.doi.org/10.2478/aiht-2018-69-3157DOI Listing
December 2018
1 Read
0.727 Impact Factor

The association of nephrolithiasis with prescription opioid use
.

Clin Nephrol 2019 Apr;91(4):231-236

Objective: To characterize opioid utilization among those with nephrolithiasis in a national cohort.

Materials And Methods: We performed cross sectional analysis of participants in the Medical Expenditure Panel Surveys during 2008 - 2014. Sample weights were employed for analysis of complex survey design. Read More

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http://dx.doi.org/10.5414/CN109717DOI Listing
April 2019
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Total Surface Area Influences Stone Free Outcomes in Shock Wave Lithotripsy for Distal Ureteral Calculi.

J Endourol 2019 Apr 13. Epub 2019 Apr 13.

Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Introduction: Current American Urological Association guidelines recommend ureteroscopy (URS) as primary management of distal ureteral stones and shock wave lithotripsy (SWL) as a secondary option. Utilization of SWL in the management of nephrolithiasis in North America has decreased. We hypothesized that SWL continues to be an effective option in the management of distal ureteral calculi and studied data from our center in patients who received SWL for distal ureteral stones. Read More

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https://www.liebertpub.com/doi/10.1089/end.2019.0120
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http://dx.doi.org/10.1089/end.2019.0120DOI Listing
April 2019
6 Reads

Renal Colic Imaging: Myths, Recent Trends, and Controversies.

Can Assoc Radiol J 2019 Mar 7. Epub 2019 Mar 7.

NYU Winthrop-University Hospital, Mineola, New York, USA.

There has been a substantial increase in the utilization of imaging, particularly of multi-detector computed tomography (MDCT), for the evaluation of patients with suspected urolithiasis over the past 2 decades. While the diagnostic accuracy of computed tomography (CT) for urolithiasis is excellent, it has also resulted in substantial medical expenditures and increased ionizing radiation exposure. This is especially concerning in patients with known nephrolithiasis and in younger patients. Read More

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http://dx.doi.org/10.1016/j.carj.2018.09.008DOI Listing
March 2019
5 Reads

Vitamin D Supplementation and Risk of Hypercalciuria in Stone Formers.

Iran J Kidney Dis 2019 Jan;13(1):27-31

Department of Nephrology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Whether administrating of vitamin D supplements increases the risk of hypercalciuria is still unanswered. The aim of the present study was to determine whether use of vitamin D supplementation might increase the risk of hypercalciuria.

Methods And Materials: This interventional study was conducted on 30 who suffered from vitamin D insufficiency and deficiency and also had a history of nephrolithiasis. Read More

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January 2019
3 Reads

Vitamin D metabolism in dogs with and without hypercalciuric calcium oxalate urolithiasis.

J Vet Intern Med 2019 Mar 9;33(2):758-763. Epub 2019 Mar 9.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota.

Background: There are abnormalities in vitamin D metabolism in people with calcium nephrolithiasis, but limited data are available on vitamin D status in dogs with calcium oxalate (CaOx) urolithiasis.

Objective: To compare serum concentrations of vitamin D metabolites in dogs with and without hypercalciuric CaOx urolithiasis.

Animals: Thirty-eight dogs with (n = 19) and without (n = 19) a history of CaOx urolithiasis and hypercalciuria. Read More

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http://dx.doi.org/10.1111/jvim.15442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430952PMC
March 2019
2 Reads

A preliminary survey of practice patterns across several European kidney stone centers and a call for action in developing shared practice.

Urolithiasis 2019 Mar 8. Epub 2019 Mar 8.

U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Via G. Moscati 31, 00168, Roma, Italy.

Currently an evidence-based approach to nephrolithiasis is hampered by a lack of randomized controlled trials. Thus, there is a need for common platforms for data sharing and recruitment of patients to interventional studies. A first step in achieving this objective would be to share practice methods and protocols for subsequent standardization in what is still a heterogeneous clinical field. Read More

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http://dx.doi.org/10.1007/s00240-019-01119-zDOI Listing
March 2019
1 Read

Large incidental gastrointestinal stromal tumors in a patient presenting with acutely symptomatic nephrolithiasis: A case report.

Radiol Case Rep 2019 May 26;14(5):555-560. Epub 2019 Feb 26.

Cooper University Hospital, Division of Body Imaging, Department of Radiology, 1 Cooper Plaza, Camden, NJ 08103, USA.

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms, representing approximately 1%-2% of all primary gastrointestinal malignancies. Incidental GISTs are often less than 1 cm when discovered and have been reported predominantly in obese patients undergoing surgery for other medical indications. We present the rare case of a large incidental GIST in a nonobese patient with acutely symptomatic nephrolithiasis. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393756PMC
May 2019
1 Read

Only Size Matters in Stone Patients: Computed Tomography Controlled Stone-Free Rates after Mini-Percutaneous Nephrolithotomy.

Urol Int 2019 Mar 7:1-6. Epub 2019 Mar 7.

University Hospital for Urology, Klinikum Oldenburg, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany,

Objective: To examine and predicting stone-free rates (SFRs) after minimally invasive-percutaneous nephrolithotomy (mini-PNL) based on computed tomography (CT), instead of X-ray or ultrasound control.

Patients And Methods: We identified 146 mini-PNL patients with pre- and postoperative CT scans. Patient and stone characteristics were assessed. Read More

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http://dx.doi.org/10.1159/000497442DOI Listing
March 2019
1 Read

Normocalcemic Primary Hyperparathyroidism in Adults Without a History of Nephrolithiasis or Fractures: A Prospective Study.

Horm Metab Res 2019 Mar 6. Epub 2019 Mar 6.

Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

The prevalence and the diagnostic criterion of "normocalcemic" primary hyperparathyroidism (NPHPT) are still uncertain and there is no consensual definition. This prospective study evaluated the prevalence of NPHPT in 676 adults without a history of fractures or nephrolithiasis and who would be submitted to thyroidectomy, the impact of adopting different cut-off values for 25-hydroxyvitamin D and estimated glomerular filtration rate (eGFR), and the agreement between biochemical diagnosis and the surgical finding of altered parathyroid glands. NPHPT was diagnosed in patients with normal total and ionized calcium and elevated PTH (in 2 measurements) and without a known cause of secondary HPT, including eGFR<40 ml/min/1. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0859-1020
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http://dx.doi.org/10.1055/a-0859-1020DOI Listing
March 2019
6 Reads

A Retrospective Study of Kidney Stone Recurrence in Adults.

J Clin Med Res 2019 Mar 13;11(3):208-212. Epub 2019 Feb 13.

Department of Urology Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated With Guangzhou University of Chinese Medicine, Zhongshan City, China.

Background: Nephrolithiasis or kidney stone disease (KSD) is a common disorder worldwide. Despite the availability of a variety of effective management strategies, KSD recurrence remains a problem. In the present study, we investigated the KSD recurrence after the treatment of the first stone episode. Read More

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http://dx.doi.org/10.14740/jocmr3753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396780PMC
March 2019
4 Reads

Mice With a Brd4 Mutation Represent a New Model of Nephrocalcinosis.

J Bone Miner Res 2019 Mar 4. Epub 2019 Mar 4.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Nephrolithiasis (NL) and nephrocalcinosis (NC), which comprise renal calcification of the collecting system and parenchyma, respectively, have a multifactorial etiology with environmental and genetic determinants and affect ∼10% of adults by age 70 years. Studies of families with hereditary NL and NC have identified >30 causative genes that have increased our understanding of extracellular calcium homeostasis and renal tubular transport of calcium. However, these account for <20% of the likely genes that are involved, and to identify novel genes for renal calcification disorders, we investigated 1745 12-month-old progeny from a male mouse that had been treated with the chemical mutagen N-ethyl-N-nitrosourea (ENU) for radiological renal opacities. Read More

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http://dx.doi.org/10.1002/jbmr.3695DOI Listing
March 2019
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Defining a clinically significant struvite stone: a non-randomized retrospective study.

Int Urol Nephrol 2019 Apr 4;51(4):585-591. Epub 2019 Mar 4.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Objective: To study the association between a stone's struvite content and clinical outcomes and to determine a clinically significant cutoff for defining struvite stones.

Materials And Methods: This was a retrospective study of all patients who underwent ureteroscopy or PCNL at our institution between 2012 and 2017 and had any component of struvite in the stone analysis. Patients were divided into four groups based on percent struvite content: A (1-25%), B (26-50%), C (51-75%), and D (76-100%). Read More

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http://dx.doi.org/10.1007/s11255-019-02117-1DOI Listing
April 2019
3 Reads

Kidney Stones and Risk of Narcotic Use.

J Urol 2019 Feb 25:101097JU0000000000000197. Epub 2019 Feb 25.

Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts.

Purpose: The rise in opioid related deaths and addiction has been linked to physician prescribing. Opioids are commonly prescribed to patients with renal colic due to nephrolithiasis. The aim of this study was to describe the relationship between nephrolithiasis and opioid use in the United States. Read More

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http://dx.doi.org/10.1097/JU.0000000000000197DOI Listing
February 2019
10 Reads

Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.

BMJ Open 2019 Mar 1;9(3):e025453. Epub 2019 Mar 1.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: To estimate the current prevalence of cardiovascular disease risk factors (CRFs) and renal disorders across serum uric acid (SUA) quartiles, and evaluate the relationships between SUA and CRFs and renal diseases in Shanghai population.

Study Design: Observational, cross-sectional study.

Setting: Data were obtained from the physical check-up of local residents at three hospitals in Shanghai. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429858PMC
March 2019
5 Reads

Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department.

Ann Emerg Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Emergency Medicine, Albert Einstein College of Medicine, Montefiore, Bronx, NY.

Study Objective: We compare the efficacy and safety of intravenous lidocaine with that of hydromorphone for the treatment of acute abdominal pain in the emergency department (ED).

Methods: This was a randomized, double-blind, clinical trial conducted in 2 EDs in the Bronx, NY. Adults weighing 60 to 120 kg were randomized to receive 120 mg of intravenous lidocaine or 1 mg of intravenous hydromorphone. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.01.021DOI Listing
February 2019
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Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway.

J Transl Med 2019 Feb 28;17(1):62. Epub 2019 Feb 28.

Department of Urology, Shanghai Changhai Hospital, Shanghai, 200433, China.

Background: The morbidity of nephrolithiasis is 2-3 times higher in males than in females, suggesting that androgen plays a key role in nephrolithiasis. The death of renal tubular epithelial cells (TECs) is an important pathophysiological process contributing to the development of nephrolithiasis. Therefore, the aim of this study is to investigate whether androgen directly induces TECs apoptosis and necrosis and its underlying mechanisms in kidney stone formation. Read More

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http://dx.doi.org/10.1186/s12967-019-1821-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394048PMC
February 2019
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Medical dissolution therapy for the treatment of uric acid nephrolithiasis.

World J Urol 2019 Feb 27. Epub 2019 Feb 27.

Department of Urology, The Ohio State University Wexner Medical Center, 915 Olentangy River Road, Columbus, OH, 43212, USA.

Introduction: Uric acid (UA) nephrolithiasis represents 10% of kidney stones in the US with low urine pH and high saturation of UA as the main risk factors for stone development. Dissolution therapy for UA kidney stones via urinary alkalization has been described as a treatment option. We present our experience in treating UA nephrolithiasis with medical dissolution therapy. Read More

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http://dx.doi.org/10.1007/s00345-019-02688-9DOI Listing
February 2019
2 Reads

Laparoscopic Transperitoneal Nephrectomy in Non-functioning Severe Hydronephrotic Kidneys With or Without Renal Stone.

Cureus 2018 Dec 13;10(12):e3729. Epub 2018 Dec 13.

Urology, University of Health Sciences Tepecik Training and Research Hospital, Izmir, TUR.

Aim To investigate the effects of the additional presence of nephrolithiasis on the results of laparoscopic simple nephrectomy in patients with severe hydronephrotic non-functional kidneys. Patients and methods A total of 43 patients in whom severe hydronephrosis had been determined on spiral computerized tomography, who had a renal function of lower than 10% according to the dimercaptosuccinic acid (DMSA) renal scintigraphy, and who had undergone a laparoscopic simple nephrectomy due to persistent renal pain and/or recurrent urinary tract infection and/or unresolved hypertension with multidrug treatment, were included in the study. The patients were divided into two groups based on the presence of renal stone as those with stone formation (Group 1) and those without stone formation (Group 2). Read More

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http://dx.doi.org/10.7759/cureus.3729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384035PMC
December 2018
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Oxalate induces type II epithelial to mesenchymal transition (EMT) in inner medullary collecting duct cells (IMCD) and stimulate the expression of osteogenic and fibrotic markers in kidney medulla .

Oncotarget 2019 Feb 1;10(10):1102-1118. Epub 2019 Feb 1.

Nephrology Division, Department of Medicine, Federal University of São Paulo, São Paulo, SP, Brazil.

EMT occurs in response to a number of stresses conditions as mechanical stretch, cancer, hypoxia, oxidative stress (ROS), among others. EMT describes a phenotypical change induced in epithelial cells. It is characterized by increases in motility, extracellular matrix synthesis, proliferation, and invasiveness. Read More

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http://dx.doi.org/10.18632/oncotarget.26634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383687PMC
February 2019