23,480 results match your criteria Nephrolithiasis

The impact of smart technology on adherence rates and fluid management in the prevention of kidney stones.

Urolithiasis 2021 Jun 11. Epub 2021 Jun 11.

Glickman Urology and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q-10, Cleveland, OH, 44195, USA.

Smart technology (ST) can enhance chronic disease management, yet little is known about the benefits of ST on kidney stone prevention. Our aim was to prospectively evaluate the impact of ST on follow-up adherence rates and urine output (UOP) in patients with nephrolithiasis. Kidney stone patients with low UOP (< 2. Read More

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Macrophage Function in Calcium Oxalate Kidney Stone Formation: A Systematic Review of Literature.

Front Immunol 2021 24;12:673690. Epub 2021 May 24.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Background: The global prevalence and recurrence rate of kidney stones is very high. Recent studies of Randall plaques and urinary components , and including gene manipulation, have attempted to reveal the pathogenesis of kidney stones. However, the evidence remains insufficient to facilitate the development of novel curative therapies. Read More

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[Necrotizing Fasciitis of the Right Thigh Caused by Emphysematous Pyelonephritis Due to a Staghorn Stone : A Case Report].

Hinyokika Kiyo 2021 Apr;67(4):147-152

The Department of Urology, Muroran City General Hospital.

We report a rare case of necrotizing fasciitis in the thigh induced by emphysematous pyelonephritis due to a staghorn stone. A 60-year-old female was diagnosed with a staghorn stone in the right kidney at another clinic. We referred her to another hospital for indication of percutaneous nephrolithotripsy. Read More

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[Efficacy and Safety of Retrograde Ureterorenoscopic Lithotripsy for Patients with Renal or Ureteral Anatomic Abnormalities or Urinary Diversion].

Hinyokika Kiyo 2021 Apr;67(4):133-139

The Department of Urology, Ijinkai Takeda General Hospital.

Retrograde ureterorenoscopic lithotripsy is one of the first-line therapies for urolithiasis. In some cases, however, thisapproach may be difficult to adopt because of factorss uch asrenal/ureteral anatomic abnormalities or urinary diversion. This study aims to investigate the safety and efficacy of retrograde ureterorenoscopic lithotripsy in patients with the above-mentioned conditions. Read More

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Normocalcemic Primary Hyperparathyroidism: Need for a Standardized Clinical Approach.

Endocrinol Metab (Seoul) 2021 Jun 1. Epub 2021 Jun 1.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, USA.

Since normocalcemic primary hyperparathyroidism (NHPT) was first defined at the Third International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism in 2008, many papers have been published describing its prevalence and possible complications. Guidelines for the management of this condition are still lacking, and making the diagnosis requires fulfillment of strict criteria. Recent studies have shown that intermittent oscillations of serum calcium just below and slightly above the normal limits are very frequent, therefore challenging the assumption that serum calcium must be consistently normal to make the diagnosis. Read More

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Results of a Gene Panel Approach in a Cohort of Patients with Incomplete Distal Renal Tubular Acidosis and Nephrolithiasis.

Kidney Blood Press Res 2021 Jun 9:1-6. Epub 2021 Jun 9.

U.O.S. Terapia Conservativa della Malattia Renale Cronica, U.O.C. Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Distal renal tubular acidosis (dRTA) is characterized by an impairment of urinary acidification resulting in metabolic acidosis, hypokalemia, and inappropriately elevated urine pH. If not treated, this chronic condition eventually leads to nephrocalcinosis, nephrolithiasis, impaired renal function, and bone demineralization. dRTA is a well-defined entity that can be diagnosed by genetic testing of 5 genes known to be disease-causative. Read More

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The Unforeseen Diagnosis: Hyperparathyroidism-Jaw Tumour Syndrome Case Report and Review of the Literature.

Case Rep Endocrinol 2021 20;2021:5551203. Epub 2021 May 20.

Milton Keynes University Hospital, Standing Way, Eaglestone, Milton Keynes MK6 5LD, UK.

Hypercalcaemia and its systemic sequelae are a relatively common finding amongst patients in the field of endocrinology. Primary hyperparathyroidism, a frequent cause of hypercalcaemia, is often seen among middle-aged female patients, typically resulting from an underlying single-gland adenoma. Although patients may present with symptoms (nephrolithiasis, musculoskeletal discomfort, dehydration, or mood disturbance, to name a few), hypercalcaemia is rather frequently identified incidentally. Read More

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PKD2 gene variants in Chinese patients with autosomal dominant polycystic kidney disease.

Clin Genet 2021 Jun 7. Epub 2021 Jun 7.

Department of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, China.

PKD2 gene variants account for 4.5% to 20% of patients with autosomal dominant polycystic kidney disease (ADPKD). Little is known about the clinical characteristics of PKD2 variants in Chinese patients with ADPKD. Read More

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Towards solving the riddle of nephrolithiasis: a South Africa perspective.

S Afr J Surg 2020 Dec;58(4):213-215

Division of Urology, Groote Schuur Hospital, University of Cape Town, South Africa.

Introduction: South Africa has a rich tradition in urinary tract stone research. This paper asks what research originating from South Africa has contributed to the understanding of the pathophysiology of nephrolithiasis. Many of these contributions are based on the premise that ethnicity variation accounts for dramatic differences in the prevalence of nephrolithiasis and that South Africa represents an ideal place for investigating this variation. Read More

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December 2020

General and dietary oxalate restriction advice reduces urinary oxalate in the stone clinic setting.

S Afr J Surg 2020 Dec;58(4):210-212

Division of Urology, Groote Schuur Hospital, University of Cape Town, South Africa.

Background: Idiopathic hyperoxaluria is a risk factor for developing calcium oxalate nephrolithiasis. Dietary oxalate's effect on urinary oxalate is not well studied. The aim of this study is to assess the effect of advice focused on reducing dietary oxalate in a cohort of idiopathic hyperoxaluric patients. Read More

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December 2020

Renal Papillary Necrosis Associated With Normocalcemic Primary Hyperparathyroidism.

AACE Clin Case Rep 2021 Mar-Apr;7(2):113-116. Epub 2020 Dec 28.

Department of Endocrinology, Diabetes & Metabolism, Walter Reed National Military Medical Center, Bethesda, Maryland.

Objectives: Renal papillary necrosis (RPN) occurring in primary hyperparathyroidism (PHPT) has not been reported. We present a 50-year-old woman who manifested RPN associated with hypercalciuria and normocalcemic PHPT.

Methods: The diagnosis of RPN was based on imaging studies (ultrasound and computed tomography [CT] scan). Read More

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December 2020

Human jackstone arms show a protein-rich, X-ray lucent core, suggesting that proteins drive their rapid and linear growth.

Urolithiasis 2021 Jun 6. Epub 2021 Jun 6.

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.

Jackstone calculi, having arms that extend out from the body of the stone, were first described over a century ago, but this morphology of stones has been little studied. We examined 98 jackstones from 50 different patient specimens using micro-computed tomography (micro CT) and infrared (IR) spectroscopy. Micro CT showed that jackstone arms consisted of an X-ray lucent core within each arm. Read More

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Improving Compliance with 24-H Urine Collections: Understanding Inadequacies in the Collection Process and Risk Factors for Poor Compliance.

Curr Urol Rep 2021 Jun 4;22(8):38. Epub 2021 Jun 4.

Department of Urology, Einstein Healthcare Network, 1200 W. Tabor Road 3 Sley Building/MossRehab, Philadelphia, PA, 19141, USA.

Purpose Of Review: The purpose of this review paper is to describe the 24-h urine collection in terms of its utility, collection process, and common problems with its acquisition.

Recent Findings: Although 24-h urine collections are standard of care for high-risk stone formers, several nuances in test acquisition including inaccurate urine collections 50% of the time and poor patient compliance limit its potential utility. Compliance in obtaining 24-h urine collections has been shown to be improved in patients who have not undergone surgical treatment of urinary calculi, patients with metabolic stone disease or family history of stone disease, Caucasian ethnicity, and in those with more sedentary occupations. Read More

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Extremely rapid stone formation in cystinuria: look out for dietary supplements!

Clin Kidney J 2021 Jun 28;14(6):1694-1696. Epub 2021 Jan 28.

Nephrology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Cystinuria is an autosomal recessive disease characterized by recurrent nephrolithiasis. The prevention of new stones is based on diluting and alkalinizing urine, as well as a low salt and moderate protein intake. The avoidance of food rich in methionine (the precursor of cystine) is also advocated. Read More

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Recidivant infective lithiasis: Is it possible to defeat them?

Arch Esp Urol 2021 Jun;74(5):527-531

Servicio de Urología. Hospital Universitario Fundación Jiménez Díaz. Madrid. España.

Acidifying treatment and control of urinary pH may be an effective strategy to address recurrent lithiasic disease secondary to infective calculi. We present the case of a 39-year-old man with bilateral urolithiasis that led to episodes of complicated Reno ureteral colic.After undergoing multiple treatments by retrograde endourological surgery, he presented recurrence and progression of lithiasis disease, finally requiring percutaneous approach for treatment of a coralliform stone, after which he was free of lithiasis. Read More

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The effect of renal localization on the fate of clinically insignificant residual fragments after retrograde intrarenal surgery: A prospective 1-year follow-up study.

Arch Esp Urol 2021 Jun;74(5):511-518

Clinic of Urology. Diskapi Yildirim Beyazit Training and Research Hospital. University of Health Sciences. Ankara. Turkey.

Objectives: Even after a successful retrograde intrarenal surgery (RIRS), clinically insignificant residual fragments (CIRF) could not pass from the kidney. We aimed to find out the differences on the fate of CIRF according to being in the lower pole or other renal localizations.

Methods: 81 patients whose stones were fragmented completely by RIRS were subdivided into two groups as group 1 (lower pole with 41 patients) and group 2 (upper pole, midpole, and renal pelvis with 40 patients). Read More

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[Assessment of radiopaque kidney stone treatment: Combination of extracorporeal shock wave lithotripsy and Fagolitos Plus®. Preliminary case control description.]

Arch Esp Urol 2021 Jun;74(5):489-493

Servicio de Urología. Hospital Universitario Clínico San Cecilio. Granada. España. Instituto IBS Granada. Granada. España.

Introduction: The nutritional supplement called Fagolitos plus® contains hydroxycitric acid as main component, in addition to zinc, magnesium, vitamin A and vitamin B6. It is necessary to study new molecules as chemolytic treatment in calcium lithiasis or that facilitate its fragmentation with the help of other instrumental treatments.

Objective: The objective of this study is to evaluate the effectiveness of the combined treatment of Fagolitos plus® and extracorporeal lithotripsy in the fragmentation of the lithiasis. Read More

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Factors Affecting Tissue Cavitation during Burst Wave Lithotripsy.

Ultrasound Med Biol 2021 May 30. Epub 2021 May 30.

Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle, Washington, USA.

Burst wave lithotripsy (BWL) is a technology under clinical investigation for non-invasive fragmentation of urinary stones. Under certain ranges of ultrasound exposure parameters, this technology can cause cavitation in tissue leading to renal injury. This study sought to measure the focal pressure amplitude needed to cause cavitation in vivo and determine its consistency in native tissue, in an implanted stone model and under different exposure parameters. Read More

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Critical Reappraisal of Methods for Measuring Urine Saturation with Calcium Salts.

Molecules 2021 May 25;26(11). Epub 2021 May 25.

Dipartimento di Chimica, Università di Torino, via P. Giuria 7, 10125 Torino, Italy.

: Metabolic and physicochemical evaluation is recommended to manage the condition of patients with nephrolithiasis. The estimation of the saturation state (β values) is often included in the diagnostic work-up, and it is preferably performed through calculations. The free concentrations of constituent ions are estimated by considering the main ionic soluble complexes. Read More

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Incidence and Characteristics of Kidney Stones in Patients on Ketogenic Diet: A Systematic Review and Meta-Analysis.

Diseases 2021 May 25;9(2). Epub 2021 May 25.

Department of Medicine, Mayo Clinic, Division of Nephrology and Hypertension, Rochester, MN 55905, USA.

Very-low-carbohydrate diets or ketogenic diets are frequently used for weight loss in adults and as a therapy for epilepsy in children. The incidence and characteristics of kidney stones in patients on ketogenic diets are not well studied. A systematic literature search was performed, using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from the databases' inception through April 2020. Read More

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Transporters and tubule crystals in the insect Malpighian tubule.

Curr Opin Insect Sci 2021 May 24;47:82-89. Epub 2021 May 24.

Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, 200 First Street SW, Rochester, MN 55905, USA; Nephrology and Hypertension, Mayo Clinic College of Medicine and Science, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

The insect renal (Malpighian) tubules are functionally homologous to the mammalian kidney. Accumulating evidence indicates that renal tubule crystals form in a manner similar to mammalian kidney stones. In Drosophila melanogaster, crystals can be induced by diet, toxic substances, or genetic mutations that reflect circumstances influencing or eliciting kidney stones in mammals. Read More

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Treatment options for managing obesity in chronic kidney disease.

Curr Opin Nephrol Hypertens 2021 May 25. Epub 2021 May 25.

Section of Nephrology, Department of Medicine, Selzman Institute for Kidney Health, Baylor College of Medicine, Houston University of Texas at Austin, Austin Section of Nephrology, Michael E. DeBakey Veterans Affairs Medical Center Institute of Clinical and Translational Research, Baylor College of Medicine VA Health Services Research and Development Center for Innovations in Quality, Effectiveness, and Safety, Houston, Texas, USA.

Purpose Of Review: Obesity is a risk factor for the development and progression of chronic kidney disease (CKD). In this review, we provide a comprehensive overview of various management options (lifestyle intervention, medications, and bariatric surgery) to address obesity in those with CKD.

Recent Findings: Few clinical trials have examined the benefits of lifestyle modifications in those with preexisting CKD and suggest potential renal and cardiovascular benefits in this population. Read More

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Donor kidney lithiasis and back-table endoscopy: a successful combination.

Acta Chir Belg 2021 May 31:1-4. Epub 2021 May 31.

Department of Urology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Introduction: Urolithiasis in renal allografts is relatively rare with an incidence of 0.17-4.40%. Read More

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Secondary stone formation 8 weeks after percutaneous nephrolithotomy treatment: A case report.

Medicine (Baltimore) 2021 May;100(21):e26091

Department of Urology, Affiliated Longhua People's Hospital.

Introduction: This work reports a patient with recurrent renal calculi subjected to three surgeries in half a year to be in the same position, and the high-throughput sequencing data showed different species in the renal pus and urine samples, which suggested that partial renal infection or stone formation can be judged by the bacteria in urine.

Patient Concerns: The female patient aged 43 years was referred to the authors' department on April 13, 2020, due to left waist pain and fever for 3 days.

Diagnosis: Kidney stones and hydronephrosis were determined by a urinary system computed tomography scan. Read More

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[Detection of kidney stones - Imaging and laboratory chemistry including urine analysis].

Jan Tuma

Ther Umsch 2021 Jun;78(5):207-213

EFSUMB Ultrasound Learning Center, Klinik Hirslanden, Zürich.

Detection of kidney stones - Imaging and laboratory chemistry including urine analysis Nephrolithiasis is often the first manifestation of renal colic. This is usually caused by ureteral stones, but also by blood clots, lost papillary necrosis, tumor-related ureteral stenosis or urogenital TB. Today, kidney stones are primarily detected by ultrasound. Read More

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[Metabolic investigation of stone formers].

Ther Umsch 2021 Jun;78(5):235-240

Abteilung Urologie, CHUV, Lausanne.

Metabolic investigation of stone formers Once a kidney stone has passed, patients must be carefully evaluated in order to identify the underlying cause of the disease and to guide preventive measures and treatment. General recommendations can be offered to all kidney stone formers, but personalized counseling and follow-up adaptations need to be guided by in-depth assessment. Metabolic evaluation for recurrent stone formers is based on 24 h urine collection. Read More

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[Recurrence prevention of kidney stones - pharmacologic and dietary measures].

Daniel G Fuster

Ther Umsch 2021 Jun;78(5):241-246

Universitätsklinik für Nephrologie und Hypertonie, Inselspital Bern.

Recurrence prevention of kidney stones - pharmacologic and dietary measures Kidney stone episodes are traumatic events for affected patients and the risk of recurrence is high. Both prevalence and incidence of kidney stone disease are rising globally, and associated cost are gigantic. Hence, effective, well-tolerated and cheap measures for recurrence prevention are of utmost importance. Read More

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[Risk factors for urolithiasis].

Nilufar Mohebbi

Ther Umsch 2021 Jun;78(5):223-227

Praxis und Dialysezentrum Zürich-City AG, Zürich.

Risk factors for urolithiasis The prevalence and incidence of kidney stones has continuously increased over the last years. Recent evidence suggests that kidney stones have a substantial morbidity including chronic kidney disease and end stage kidney disease as well as significantly increased risk for cardiovascular diseases. Thus, risk stratification - especially of high-risk patients - is mandatory in the management of kidney stone patients. Read More

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[And which stone type are you?]

Ther Umsch 2021 Jun;78(5):229-234

Universitätsklinik für Nephrologie und Hypertonie, Inselspital Bern.

And which stone type are you? Knowledge about the stone type is essential for therapy, prophylaxis and prognosis of kidney stone disease. Stone types can completely change in the course of a stone disease and therefore every kidney stone should be analyzed. This narrative review deals with some aspects of methods for analysis and types of kidney stones, with frequencies of different stone types as well as with general and specific mechanisms of kidney stone formation and seeks to stimulate a more in-depth study of this topic. Read More

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