4,031 results match your criteria Nephrogenic Systemic Fibrosis


Gadolinium-based contrast agents: why nephrologists need to be concerned.

Curr Opin Nephrol Hypertens 2018 Dec 3. Epub 2018 Dec 3.

Kidney Institute of New Mexico.

Purpose Of Review: The hegemony of gadolinium-based contrast agent-induced adverse events stretches beyond those who have renal impairment. 'Nephrogenic' systemic fibrosis is a misnomer: gadolinium-based contrast agents are the known trigger for the disease; kidney impairment is a risk factor. Impaired (true) glomerular filtration may be one catalyst for gadolinium-based contrast agent-induced adverse events, but it is increasingly evident that the same cluster of symptoms occurs in patients with normal renal function. Read More

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December 2018

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
3 Reads

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.

J Am Soc Nephrol 2018 Dec 5. Epub 2018 Dec 5.

III. Department of Medicine,

Background: Nephron number is a major determinant of long-term renal function and cardiovascular risk. Observational studies suggest that maternal nutritional and metabolic factors during gestation contribute to the high variability of nephron endowment. However, the underlying molecular mechanisms have been unclear. Read More

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December 2018
1 Read

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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December 2018

The role of the ureteric bud in the development of the ovine fetal kidney.

J Pediatr Surg 2018 Dec 1;53(12):2502-2506. Epub 2018 Sep 1.

Division of Pediatric Surgery, St. Marianna University School of Medicine, Kawasaki, Japan. Electronic address:

Background: The kidney develops from an intimate interaction between the ureteric bud and the metanephric mass. We attempted to differentially stain the derivatives of the ureteric bud and the metanephric mass in ovine fetuses.

Methods: After appropriate approval, 47 fetal lambs' kidneys at 50 (4), 60 (6), 70 (5), 80 (4), 100 (10), 110 (8), 145 (10) days' gestation (term is 140-145 days) were obtained. Read More

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December 2018

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.

Elife 2018 12 5;7. Epub 2018 Dec 5.

Department of Stem Cell Biology and Regenerative Medicine, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, United States.

A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell organization and interactions within the nephrogenic niche, ultimately determining nephron endowment. In mutants, nephron progenitors dispersed from their restricted niche, intermixing with interstitial progenitors. Read More

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December 2018
2 Reads

The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists.

Metallomics 2018 Dec 5. Epub 2018 Dec 5.

The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Charlestown, Massachusetts 02129, USA.

Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually worldwide. GBCAs are hydrophilic, thermodynamically stable and kinetically inert gadolinium chelates. In clinical MRI, 5-10 millimoles of Gd ion is administered intravenously and the GBCA is rapidly eliminated intact primarily through the kidneys into the urine. Read More

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December 2018
2 Reads

Evaluating the Patient with Reported Gadolinium-Associated Illness.

J Med Toxicol 2018 Nov 29. Epub 2018 Nov 29.

Department of Emergency Medicine, Hartford Hospital, 80 Seymour St, Room 139, Hartford, CT, 06103, USA.

Introduction: Gadolinium-based contrast agents (GBCAs) have been increasingly used in clinical practice since their introduction in the 1980s. Recently, increased public attention has been given to patients who report new symptoms following GBCA exposure. This review details the current knowledge surrounding GBCAs, with a focus on the known and proposed disease states that may be associated with GBCAs. Read More

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November 2018

Regulation of Renal Differentiation by Trophic Factors.

Front Physiol 2018 12;9:1588. Epub 2018 Nov 12.

Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Classically, trophic factors are considered as proteins which support neurons in their growth, survival, and differentiation. However, most neurotrophic factors also have important functions outside of the nervous system. Especially essential renal growth and differentiation regulators are glial cell line-derived neurotrophic factor (GDNF), bone morphogenetic proteins (BMPs), and fibroblast growth factors (FGFs). Read More

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November 2018

Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function exposed to Gd-based contrast agents.

Toxicol Lett 2018 Nov 23;301:157-167. Epub 2018 Nov 23.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy. Electronic address:

Gadolinium deposition in tissue is linked to nephrogenic systemic fibrosis (NSF): a rare disorder occurring in patients with severe chronic kidney disease and associated with administration of Gd-based contrast agents (GBCAs) for Magnetic Resonance Imaging (MRI). It is suggested that the GBCAs prolonged permanence in blood in these patients may result in a Gd precipitation in peripheral or central organs, where it initiates a fibrotic process. In this study we investigated new sites of retention/precipitation of Gd in a mouse model of renal disease (5/6 nephrectomy) receiving two doses (closely after each other) of a linear GBCA. Read More

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November 2018
3 Reads

Influence of excess ligand on Nephrogenic Systemic Fibrosis associated with nonionic, linear gadolinium-based contrast agents.

Magn Reson Imaging 2018 Nov 21. Epub 2018 Nov 21.

Department of Radiology, Hospital Garcia de Orta, EPE, Almada, Portugal.

Background: The molecular structure, charge, thermodynamic and kinetic stability are approximately the same for gadodiamide and gadoversetamide, the main substantive difference is that gadodiamide is manufactured with 5% free ligand to form Omniscan® and gadoversetamide with 10% free ligand to form OptiMARK®.

Purpose: To determine the relative risk of Nephrogenic Systemic Fibrosis (NSF) between gadodiamide (Omniscan®) and gadoversetamide (OptiMARK®) and to explore the potential contribution of the amount of excess ligand added to their commercial formulations.

Materials And Methods: In this retrospective observational study, the number of doses and NSF cases associated with these agents were calculated based on two different approaches: the number of doses was determined based on pharmaceutical companies' information, and the number of unconfounded NSF cases was obtained from the previously published literature based on a legal database. Read More

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November 2018

Nephrogenic Diabetes Insipidus.

Pediatr Clin North Am 2019 Feb;66(1):227-234

Department of Pediatric Nephrology, Columbia University Medical Center, 3959 Broadway, CHN 1115, New York, NY 10032, USA. Electronic address:

Nephrogenic diabetes insipidus (NDI) results from the inability of the late distal tubules and collecting ducts to respond to vasopressin. The lack of ability to concentrate urine results in polyuria and polydipsia. Primary and acquired forms of NDI exist in children. Read More

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February 2019
6 Reads

[Morphometrical evaluation of fetuses and newborns kidneys status developing under maternal iron deficiency anemaia conditions].

Wiad Lek 2018 ;71(7):1222-1230

Kharkiv National Medical University, Kharkiv, Ukraine.

Objective: Introduction: Kidneys in fetuses and newborns play an important role in the homeostasis regulation and are the most vulnerable to the action of damaging factors from the mother organism, therefore it is important to timely assess their morphofunctional state. The aim: The purpose of the study was to reveal the morphometrical features of fetuses and newborns kidneys from mothers, whose pregnancy was complicated by iron deficiency anemia of varying degrees of severity.

Patients And Methods: Materials and methods: The material of the study was the tissue of kidneys of mature fetuses and newborns from mothers with physiological pregnancy (28 cases), as well as from mothers whose pregnancy was complicated by iron deficiency anemia of varying degrees of severity (85 cases). Read More

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January 2018
2 Reads

Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts.

Am J Physiol Renal Physiol 2018 Nov 14. Epub 2018 Nov 14.

School of Medicine Renal Division, Emory University, United States.

Hypertonicity increases water permeability, independently of vasopressin, in the inner medullary collecting duct (IMCD) by increasing aquaporin-2 (AQP2) membrane accumulation. We investigated whether protein kinase C (PKC) and adenosine monophosphate kinase (AMPK) are involved in hypertonicity-regulated water permeability. Increasing perfusate osmolality from 150-290 mosM and bath osmolality from 290-430 mosM significantly stimulated osmotic water permeability. Read More

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November 2018

Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats.

Clin Exp Nephrol 2018 Nov 13. Epub 2018 Nov 13.

Division of Nephrology and Endocrinology, Tohoku Medical and Pharmaceutical University, 1-15-1, Fukumuro, Miyagino, Sendai, 983-8536, Japan.

Background: Tolvaptan is an effective treatment for polycystic kidney disease (PKD), but also causes unfortunate polyuria. Hydrochlorothiazide (HCTZ) has been shown to reduce urine volume in nephrogenic diabetes insipidus, raising the possibility that HCTZ could also be effective in reducing tolvaptan-induced polyuria. In this study, we examined the combined administration of HCTZ and tolvaptan. Read More

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November 2018
8 Reads

[Clinicopathologic features of primary renal neuroendocrine carcinoma].

Zhonghua Bing Li Xue Za Zhi 2018 Nov;47(11):851-856

Department of Pathology, School of Basic Medicine of Qingdao University, Qingdao 266003, China.

To investigate the clinicopathologic characteristics, diagnostic features and prognosis of primary renal neuroendocrine carcinoma (NEC). The clinicopathologic data of eight cases of renal NEC was collected from January 2008 to December 2017 from Affiliated Hospital of Qingdao University. Immunohistochemical staining was performed, and follow-up information was analyzed, and the relevant literature reviewed. Read More

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November 2018
3 Reads

Small non-coding RNA expression in mouse nephrogenic mesenchymal progenitors.

Sci Data 2018 Nov 13;5:180218. Epub 2018 Nov 13.

Rangos Research Center, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

MicroRNAs (miRNAs) are small non-coding RNAs that are essential for the regulation of gene expression and play critical roles in human health and disease. Here we present comprehensive miRNA profiling data for mouse nephrogenic mesenchymal progenitors, a population of cells enriched for nephron progenitors that give rise to most cell-types of the nephron, the functional unit of the kidney. We describe a miRNA expression in nephrogenic mesenchymal progenitors, with 162 miRNAs differentially expressed in progenitors when compared to whole kidney. Read More

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November 2018
7 Reads

Papillary Adenomas and Other Small Epithelial Tumors in the Kidney: An Autopsy Study.

Am J Surg Pathol 2018 Nov 9. Epub 2018 Nov 9.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN.

The aim of this work was to study small neoplasms of the epithelium of the renal tubules; kidneys from 402 unselected autopsies were sectioned at 1 to 2 mm intervals. All lesions were examined histologically. A total of 232 papillary adenomas were found in 76 patients (19%), ranging from 1 to 35 adenomas/patient (mean: 3, median: 2). Read More

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November 2018
4 Reads

Safety of Gadolinium Administration in Children.

Pediatr Neurol 2018 Sep 27;86:27-32. Epub 2018 Jul 27.

Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio.

The introduction of paramagnetic contrast in the late 1980s constituted a paradigm shift boosting the efficacy of magnetic resonance imaging. Due to its high magnetic moment, gadolinium-based contrast agent made its way smoothly as the flagship paramagnetic contrast. With the widespread application, reports of untoward effects started to surface. Read More

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September 2018

Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification.

BMC Nephrol 2018 Nov 3;19(1):305. Epub 2018 Nov 3.

IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, 75 Pigdons Road, Geelong, Australia.

Background: Despite lithium being the most efficacious treatment for bipolar disorder, its use has been decreasing at least in part due to concerns about its potential to cause significant nephrotoxicity. Whilst the ability of lithium to cause nephrogenic diabetes insipidus is well established, its ability to cause chronic kidney disease is a much more vexing issue, with various studies suggesting both positive and negative causality. Despite these differences, the weight of evidence suggests that lithium has the potential to cause end stage kidney disease, albeit over a prolonged period. Read More

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November 2018
1 Read

Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2018 Sep 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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September 2018
2 Reads

A case report of infantile cystic nephroblastoma.

Diagn Pathol 2018 Oct 27;13(1):84. Epub 2018 Oct 27.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Background: Nephroblastoma (NB) is a malignant embryonal neoplasm derived from nephrogenic blastemal cells. NB usually forms a solid mass, but in extremely rare cases, it may show cystic changes.

Case Presentation: A six-month-old girl with persistent high fevers was found to have pyuria and bacteriuria. Read More

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October 2018
4 Reads

Decreased H3K9ac level of AT2R mediates the developmental origin of glomerulosclerosis induced by prenatal dexamethasone exposure in male offspring rats.

Toxicology 2018 Oct 22;411:32-42. Epub 2018 Oct 22.

Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan, 430071, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, 430071, China. Electronic address:

This study aimed to demonstrate that prenatal dexamethasone exposure (PDE) can induce kidney dysplasia in utero and adult glomerulosclerosis in male offspring, and to explore the underlying intrauterine programming mechanisms. Pregnant rats were subcutaneously administered dexamethasone 0.2 mg/kg. Read More

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October 2018
4 Reads

Key features of the nephrogenic zone in the fetal human kidney-hardly known but relevant for the detection of first traces impairing nephrogenesis.

Authors:
Will W Minuth

Cell Tissue Res 2018 Oct 18. Epub 2018 Oct 18.

Institute of Anatomy, University of Regensburg, 93053, Regensburg, Germany.

In healthy newborn babies, nephrogenesis proceeds unnoticed until birth. With start of the perinatal period, morphogenetic activity in the renal outer cortex consisting of an inner maturation zone and an outer nephrogenic zone is downregulated by unknown signals. One of the results is that the entire nephrogenic zone as well as the contained progenitor cells and niches disintegrate. Read More

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October 2018

Parallel generation of easily selectable multiple nephronal cell types from human pluripotent stem cells.

Cell Mol Life Sci 2018 Oct 11. Epub 2018 Oct 11.

Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Human pluripotent stem cells (hPSCs) provide a source for the generation of defined kidney cells and renal organoids applicable in regenerative medicine, disease modeling, and drug screening. These applications require the provision of hPSC-derived renal cells by reproducible, scalable, and efficient methods. We established a chemically defined protocol by application of Activin A, BMP4, and Retinoic acid followed by GDNF, which steered hPSCs to the renal lineage and resulted in populations of SIX2/CITED1 metanephric mesenchyme- (MM) and of HOXB7/GRHL2 ureteric bud (UB)-like cells already by 6 days. Read More

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October 2018
1 Read

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.

J Am Soc Nephrol 2018 Nov 10;29(11):2658-2670. Epub 2018 Oct 10.

Institute of Hypertension, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China;

Background: The bile acid-activated receptors, including the membrane G protein-coupled receptor TGR5 and nuclear farnesoid X receptor (FXR), have roles in kidney diseases. In this study, we investigated the role of TGR5 in renal water handling and the underlying molecular mechanisms.

Methods: We used tubule suspensions of inner medullary collecting duct (IMCD) cells from rat kidneys to investigate the effect of TGR5 signaling on aquaporin-2 (AQP2) expression, and examined the effects of TGR5 in mice with lithium-induced nephrogenic diabetes insipidus (NDI) and knockout () mice. Read More

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November 2018
3 Reads

[Non-iodinated contrast media nephrotoxicity].

Nephrol Ther 2018 Nov 6;14(6):484-490. Epub 2018 Oct 6.

Service Icar, hôpital de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France; Service de néphrologie, hôpital de la Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris, France.

The development of interventional radiology techniques regularly exposes patients to the potential renal toxocity of iodinated contrast media. Faced with this risk of nephrotoxicity, gadolinium-based contrast agents have long been considered as a safe alternative to iodinated contrast media, especially in sensitive or at risk patients. However, these gadolinium-based contrast agents are not devoid of nephrotoxicity and present another risk, a complication related to renal failure, the nephrogenic systemic fibrosis. Read More

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November 2018
1 Read

Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals.

Eur Radiol 2018 Oct 1. Epub 2018 Oct 1.

Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK.

Objectives: Recent safety concerns regarding gadolinium-based contrast agents (GdCAs) concluded with the suspension of some agents from the European market, yet a clinical consequence remains unknown. We used electronic health records to investigate the incidence of potential toxicity to gadoteric acid (Dotarem®) within our local population, including those with renal insufficiency (RI).

Methods: Data for patients who underwent contrast-enhanced MRI were identified, stratified by renal function at time of scan and retrospectively followed using routinely collected health data. Read More

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October 2018
1 Read

Progranulin Deficient Mice Develop Nephrogenic Diabetes Insipidus.

Aging Dis 2018 Oct 1;9(5):817-830. Epub 2018 Oct 1.

1Clinical Pharmacology, Goethe-University Hospital Frankfurt am Main, Germany.

Loss-of-function mutations of progranulin are associated with frontotemporal dementia in humans, and its deficiency in mice is a model for this disease but with normal life expectancy and mild cognitive decline on aging. The present study shows that aging progranulin deficient mice develop progressive polydipsia and polyuria under standard housing conditions starting at middle age (6-9 months). They showed high water licking behavior and doubling of the normal daily drinking volume, associated with increased daily urine output and a decrease of urine osmolality, all maintained during water restriction. Read More

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October 2018
5 Reads

Diagnosis and management of central diabetes insipidus in adults.

Clin Endocrinol (Oxf) 2018 Sep 30. Epub 2018 Sep 30.

Academic Department of Endocrinology, Beaumont Hospital/RCSI Medical School, Dublin, Ireland.

Central diabetes insipidus (CDI) is characterized by hypotonic polyuria due to impairment of AVP secretion from the posterior pituitary. In clinical practice, it needs to be distinguished from renal resistance to the antidiuretic effects of AVP (nephrogenic DI), and abnormalities of thirst appreciation (primary polydipsia). As nephrogenic diabetes insipidus is rare in adults, unless they are treated with lithium salts, the practical challenge is how to differentiate between CDI and clinical disorders of excess thirst. Read More

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September 2018
1 Read

Outcome of two patients with bilateral nephroblastomatosis/Wilms tumour treated with an add-on 13-cis retinoic acid therapy - Case report.

Pediatr Hematol Oncol 2018 Sep 27:1-7. Epub 2018 Sep 27.

a Department of Pediatric Hematology and Oncology , St. Anna Children's Hospital, Medical University of Vienna , Vienna , Austria.

Although the fate of nephrogenic rests varies, they are known to be precursors of Wilms tumour. Thus, nephrogenic rests require adequate treatment to prevent malignant transformation. We added 13-cis retinoic acid to the standard chemotherapy with vincristine and actinomycin-D in two patients with bilateral nephrogenic rests/nephroblastomatosis. Read More

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September 2018

Genetic deletion of ADP-activated P2Y receptor ameliorates lithium-induced nephrogenic diabetes insipidus in mice.

Acta Physiol (Oxf) 2018 Sep 26:e13191. Epub 2018 Sep 26.

Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah.

Aim: Therapeutic use of lithium in bipolar disorder is limited by the development of nephrogenic diabetes insipidus (NDI). We reported that pharmacological blockade of P2Y receptor (R) with clopidogrel or prasugrel significantly ameliorated lithium-induced NDI in rodents. Using mice genetically lacking P2Y -R we evaluated whether the observed amelioration is mediated through P2Y -R METHODS: P2ry12 mouse line (C57/BL6) was rederived from cryopreserved embryos of the knockout (KO) mice generated by Deltagen Inc. Read More

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September 2018
2 Reads
4.380 Impact Factor

[Mimetics of systemic sclerosis].

Z Rheumatol 2018 Sep 25. Epub 2018 Sep 25.

Klinik für Rheumatologie und klinische Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Background: Systemic sclerosis (SSc) is characterized by heterogeneous clinical symptoms. Peripheral skin fibrosis can be a common symptom. Nevertheless, a variety of diseases with different etiologies are associated with a thickening of the skin and make the initial diagnosis of systemic sclerosis more difficult. Read More

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September 2018
10 Reads

Post-marketing surveillance of gadobutrol for contrast-enhanced magnetic resonance imaging in Japan.

Jpn J Radiol 2018 Nov 19;36(11):676-685. Epub 2018 Sep 19.

Radiology, Bayer AG, Müllerstraße 178, 13353, Berlin, Germany.

Purpose: To evaluate the safety of gadobutrol for magnetic resonance imaging in a prospective, non-interventional, post-marketing surveillance in Japan.

Materials And Methods: Gadobutrol was administered in accordance with Japanese prescribing information over a 2-year enrollment period, using a standardized questionnaire to collect information. The primary outcome was the incidence of adverse reactions (ARs) following gadobutrol injection. Read More

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November 2018
10 Reads

Gadolinium Retention After Contrast-Enhanced MRI.

JAMA 2018 Nov;320(18):1853-1854

Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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November 2018

Nephrogenic systemic fibrosis: in a child with primary hyperoxaluria.

Clin Exp Dermatol 2019 01 9;44(1):70-72. Epub 2018 Sep 9.

Department of Pathology, Health Science University Şişli Hamidiye Etfal Training and Research Hospital, Etfal sok. Şişli, Istanbul, 34100, Turkey.

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January 2019

Percutaneous renal artery stent implantation in the treatment of atherosclerotic renal artery stenosis.

Exp Ther Med 2018 Sep 13;16(3):2331-2336. Epub 2018 Jul 13.

Department of Acupuncture, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, Jiangsu 225300, P.R. China.

We aimed to investigate the clinical curative effect of percutaneous renal artery stent implantation (PTRAS) in the treatment of atherosclerotic renal artery stenosis (ARAS), and to analyze the factors influencing the curative effect of PTRAS. A total of 230 patients with unilateral or bilateral renal artery stenosis were retrospectively analyzed. According to whether adverse cardiogenic or nephrogenic events occurred, 230 patients were divided into two groups to analyze the risk factors of adverse cardiogenic or nephrogenic events. Read More

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September 2018
1 Read
0.941 Impact Factor

Roles of the TGF-β⁻VEGF-C Pathway in Fibrosis-Related Lymphangiogenesis.

Int J Mol Sci 2018 Aug 23;19(9). Epub 2018 Aug 23.

Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan.

Lymphatic vessels drain excess tissue fluids to maintain the interstitial environment. Lymphatic capillaries develop during the progression of tissue fibrosis in various clinical and pathological situations, such as chronic kidney disease, peritoneal injury during peritoneal dialysis, tissue inflammation, and tumor progression. The role of fibrosis-related lymphangiogenesis appears to vary based on organ specificity and etiology. Read More

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August 2018
3 Reads

Dechelation (Transmetalation): Consequences and Safety Concerns With the Linear Gadolinium-Based Contrast Agents, In View of Recent Health Care Rulings by the EMA (Europe), FDA (United States), and PMDA (Japan).

Authors:
Val M Runge

Invest Radiol 2018 Oct;53(10):571-578

From the Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, University Hospital, University of Bern, Bern, Switzerland.

The issue of dechelation (transmetallation) in vivo after administration of the linear gadolinium-based contrast agents, and potential safety concerns, is considered on the basis of an extensive, focused literature review. Early indications of potential problems included the high level of excess ligand used in the formulation of 2 agents (indeed the 2 least stable thermodynamically) and interference with laboratory tests when blood was drawn from patients relatively soon after administration of these same agents. The advent of nephrogenic systemic fibrosis in the late 2000s raised additional major concerns. Read More

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October 2018
4 Reads

Complete Nephrogenic Diabetes Insipidus After Prolonged Sevoflurane Sedation: A Case Report About 3 Cases.

A A Pract 2018 Aug 16. Epub 2018 Aug 16.

From the Departments of Intensive Care and.

Volatile anesthetic agents, such as sevoflurane, are increasingly used for long-term sedation in intensive care units worldwide, with improved clinical outcomes reported in recent studies due to favorable pharmacological properties. Despite possible renal toxicity related to the production of plasma inorganic fluoride and concerns related to reversible impairment of renal concentrating abilities, renal injury associated with sevoflurane sedation has rarely been reported in the intensive care unit setting. We hereby report 3 cases of nephrogenic diabetes insipidus associated with prolonged sevoflurane sedation using the AnaConDa device and review the possible mechanisms of renal toxicity. Read More

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August 2018
1 Read

Double Trouble - Severe Hypernatremia Secondary to Central Diabetes Insipidus Complicated by Hypercalcemic Nephrogenic Diabetes Insipidus: A Case Report.

Am J Case Rep 2018 Aug 18;19:973-977. Epub 2018 Aug 18.

Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, USA.

BACKGROUND Patients with malignancies often have electrolyte abnormalities. We present a case of a patient with central diabetes insipidus secondary to metastatic pituitary invasion complicated by hypercalcemic nephrogenic diabetes insipidus. CASE REPORT We present a case of 40-year-old female with a history of stage IV breast cancer with skeletal and leptomeningeal metastasis, who was admitted with polyuria, polydipsia, and recent onset of confusion. Read More

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August 2018
2 Reads

[Clinicopathologic features of glomus tumor of the kidney].

Zhonghua Bing Li Xue Za Zhi 2018 Aug;47(8):580-584

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To investigate the clinicopathologic and differential diagnostic features of glomus tumor of the kidney. Four cases of glomus tumor of the kidney were collected from the archives of Peking University Third Hospital, the Second Hospital of Tianjin Medical University, Ningbo Yinzhou Second Hospital and Zhejiang Provincial People's Hospital between January 2012 to June 2017; the clinical and radiologic features, histomorphology, immunohistochemistry, ultrastucture and prognosis were analyzed and the relevant literature was reviewed. Patients consisted of 2 men and 2 women with ages ranging from 37 years to 66 years (mean 55 years). Read More

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August 2018
1 Read

A COMBINED OUTPATIENT AND INPATIENT OVERNIGHT WATER DEPRIVATION TEST IS EFFECTIVE AND SAFE IN DIAGNOSING PATIENTS WITH POLYURIA-POLYDIPSIA SYNDROME.

Endocr Pract 2018 Nov 14;24(11):963-972. Epub 2018 Aug 14.

Objective: The water deprivation test (WDT) is widely used for the differential diagnosis of the polyuria-polydipsia syndrome (PPS). However, it is inconvenient and may not always be precise in differentiating partial forms of diabetes insipidus (DI) from primary polydipsia (PP). The aim of this study was to evaluate the results of a combined outpatient and inpatient overnight WDT protocol that included an overnight unsupervised period concerning its feasibility and safety. Read More

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November 2018

Gadolinium-based contrast agents in children.

Pediatr Radiol 2018 08 4;48(9):1188-1196. Epub 2018 Aug 4.

Nemours Children's Hospital, Nemours Children's Health System, University of Central Florida College of Medicine, Orlando, FL, USA.

Gadolinium-based contrast agents (GBCAs) are widely used in medical imaging, with greater than 300 million doses administered since their introduction. The risk of adverse reactions is very low, and GBCAs were thought to be very safe until the discovery of nephrogenic systemic fibrosis (NSF). Since that time, gadolinium has been found to deposit throughout the body, including the brain, where it is visible on non-contrast T1-weighted MR images in people with normal renal function. Read More

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August 2018
1.650 Impact Factor

Four Japanese Patients with Congenital Nephrogenic Diabetes Insipidus due to the Mutations.

Case Rep Pediatr 2018 3;2018:6561952. Epub 2018 Jul 3.

Department of Pediatrics, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.

Almost 90% of nephrogenic diabetes insipidus (NDI) is caused by mutations in the arginine vasopressin receptor 2 gene () on the X chromosome. Herein, we reported clinical and biochemical parameters in four cases of three unrelated Japanese families and analyzed the status of the Two of the four patients had poor weight gain. However, in the male and female sibling cases, neither had poor weight gain while toddlers, but in the male sibling, episodes of recurrent fever, polyuria, and polydipsia led to the diagnosis of NDI at 4 years of age. Read More

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July 2018
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Chemical validation and optimization of pharmacoperones targeting vasopressin type 2 receptor mutant.

Biochem J 2018 Sep 25;475(18):2941-2953. Epub 2018 Sep 25.

Lead Identification Division, Translational Research Institute and Department of Molecular Medicine, Scripps Research Institute, Jupiter, FL 33458, U.S.A.

A series of compounds formerly identified by high-throughput screening was studied for their ability to serve as pharmacoperones for the vasopressin type 2 receptor (V2R) mutant L83Q, which is known to cause nephrogenic diabetes insipidus (NDI). Three compounds were particularly effective in rerouting the mutant receptor in a concentration-dependent manner, were neither agonists nor antagonists, and displayed low cellular toxicity. Compound 1 was most effective and can be used as a molecular probe for future studies of how small molecules may affect NDI caused by mutant V2R. Read More

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September 2018
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A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus.

N Engl J Med 2018 Aug;379(5):428-439

From the University of Leipzig, Department of Endocrinology and Nephrology (W.F., A.T.), and Leipzig University Medical Center, Integrated Research and Treatment Center Adiposity Diseases (W.F.), Leipzig, the Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg (I.C., M.K., M.F.), and the Clinical Trial Center (U.M.) and Central Laboratory (M.F.), University Hospital Würzburg, Würzburg, Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-Universität, Munich (J.S.), the Department of Neurosurgery, University Hospital Hamburg-Eppendorf, Hamburg (J.F.), and Experimental and Clinical Endocrinology, University Hospital Lübeck, Lübeck (G.B.) - all in Germany; the Clinic of Endocrinology, Diabetology and Metabolism (J.R., I.S., B.W., E.C., M.C.-C.) and the Clinical Trial Unit (D.R.V.), Department of Clinical Research, University of Basel and University Hospital Basel, Basel, the Department of Endocrinology, Kantonsspital St. Gallen, St. Gallen (T.D., S.B.), the Department of Endocrinology, Inselspital Bern, Bern (E.C.), the Department of Endocrinology, Luzerner Kantonsspital, Lucerne (C.H., S.F.), and the Division of Endocrinology, Diabetology and Metabolism, Medical University Clinic, Kantonsspital Aarau, Aarau (B.M.) - all in Switzerland; and Faculdade de Medicina da UFMG, Universidade Federal de Minas Gerais (J.D., A.R.-O.), and Hermes Pardini Institute (J.D.), Belo Horizonte, Brazil.

Background: The indirect water-deprivation test is the current reference standard for the diagnosis of diabetes insipidus. However, it is technically cumbersome to administer, and the results are often inaccurate. The current study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor-derived surrogate of arginine vasopressin. Read More

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August 2018
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Intracranial pathologies associated with central diabetes insipidus in infants.

J Pediatr Endocrinol Metab 2018 Jul 27. Epub 2018 Jul 27.

University of Tennessee Health Science Center, Memphis, TN, USA.

Background Idiopathic central diabetes insipidus (CDI) has been associated with intracranial pathologies that do not involve the structural pituitary gland or hypothalamus. The objective was to study the association between non-structural hypothalamic/pituitary intracranial pathologies (NSHPIP) with CDI and to review etiologies that may be contributory to the development of CDI. Methods A retrospective query of our intra-institutional database from 2006 to 2015. Read More

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July 2018
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Tamoxifen Decreases Lithium-Induced Natriuresis in Rats With Nephrogenic Diabetes Insipidus.

Front Physiol 2018 12;9:903. Epub 2018 Jul 12.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Lithium is widely used in the treatment of bipolar affective disorders, but often causes nephrogenic diabetes insipidus (NDI), a condition characterized by a severe urinary concentrating defect. Lithium-induced NDI is associated with dysregulation of the amiloride-sensitive epithelial sodium channel (ENaC), which is essential for renal sodium reabsorption. Sex hormones have been shown to affect the expression of aquaporin-2 (AQP2) and sodium transporters. Read More

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[Renal complications of lithium use: to cease or to continue?]

Ned Tijdschr Geneeskd 2018 May 29;162. Epub 2018 May 29.

GGZ inGeest, Amsterdam.

Lithium is the most effective maintenance therapy for patients with bipolar disorder. Important renal adverse effects of chronic lithium use include nephrogenic diabetes insipidus (prevalence circa 20%) and chronic kidney disease (prevalence circa 10-20% after 5-9 years of lithium use). Chronic lithium use is linked with slowly progressive chronic kidney disease, though it rarely leads to end-stage renal failure (prevalence of 0. Read More

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May 2018
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