78,535 results match your criteria Nephritis Radiation


Henoch-schonlein Purpura Nephritis with Renal Interstitial Lesions.

Open Med (Wars) 2018 27;13:597-604. Epub 2018 Nov 27.

Institute of Pathology, Basic Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To investigate the clinical pathology and prognosis & outcome of Henoch-Schonlein purpura nephritis (HSPN) with renal interstitial lesions.

Methods: All 148 patients were analyzed for clinical, renal pathological, and prognostic features. Patients with no, mild, and moderate- severe renal tubulo-interstitial lesions were included in group A, B and C, respectively. Read More

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November 2018

A Report of Chronic Intestinal Pseudo-obstruction Related to Systemic Lupus Erythematosus.

Open Med (Wars) 2018 25;13:562-564. Epub 2018 Nov 25.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Chronic intestinal pseudo-obstruction (CIPO) is a functional gastrointestinal disorder with symptoms of ileus. CIPO can either be idiopathic or secondary to other diseases such as systemic lupus erythematosus (SLE). SLE is involved in many parts of the gastrointestinal system with variable clinical presentations. Read More

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November 2018
1 Read

[Sjögren's Syndrome: Early diagnosis and effective treatment].

Authors:
Torsten Witte

Dtsch Med Wochenschr 2018 Dec 3;143(24):1778-1782. Epub 2018 Dec 3.

Klinik für Immunologie und Rheumatologie der Medizinischen Hochschule Hannover.

Primary Sjögren's syndrome (pSS) is an autoimmune disease affecting the salivary and lachrymal glands. The patients complain of symptoms of dry eyes and dry mouth, but up to 50 % may additionally develop extraglandular manifestations such as arthritis, vasculitis, polyneuropathy, pulmonary fibrosis or interstitial nephritis. Most therapeutic studies on the glandular manifestations of pSS failed to meet their primary endpoints, possibly since many of the patients had already advanced and irreversible disease. Read More

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December 2018
1 Read

Deciphering the SUMO code in the kidney.

J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Nephrology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis. Read More

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December 2018

Bilateral combined anterior and posterior lenticonus in Alport's Syndrome.

Rom J Ophthalmol 2018 Jul-Sep;62(3):228-230

Department of Ophthalmology, Gajra Raja Medical College, Gwalior, India.

Alport's syndrome is an inherited disease characterized by hearing loss, progressive renal failure and ocular abnormalities like anterior lenticonus, corneal opacities, cataract, fleck retinopathies, and temporal retinal thinning. To have anterior and posterior lenticonus in the same eye in this syndrome is a rare finding and only a few such reports are available. Hereby, we report a case of a 22-year-old male with bilateral combined anterior and posterior lenticonus with sensorineural deafness and nephritis leading to the diagnosis of Alport's syndrome. Read More

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December 2018

Descriptive Epidemiology of Acute Pyelonephritis in Korea, 2010-2014: Population-based Study.

J Korean Med Sci 2018 Dec 12;33(49):e310. Epub 2018 Nov 12.

Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.

Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Read More

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December 2018

[Tubulointerstitiel nephritis and Crohn's disease, nephrotoxicity or extraintestinal manifestation of Crohn's disease? About a case].

Nephrol Ther 2018 Nov 29. Epub 2018 Nov 29.

Laboratoire d'anatomie pathologique, CHRU de Nancy, 5, rue de Morvan, 54500 Vandœuvre-lès-Nancy, France.

Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. Read More

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November 2018

Kidney transplantation in systemic lupus erythematosus: Outcomes and prognosis.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Nefrología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, España; Red de Investigación Renal (REDinREN), Madrid, España.

Introduction: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]).

Materials And Methods: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. Read More

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November 2018

[Effect of miR-21 on the expression of interleukin-10 in B cell of patients with Henoch-Schonlein purpura].

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):939-944

Rheumatology & Immunology Department of Shenzhen Children's Hospital, Shenzhen 518038, China.

To investigate the effect of microRNAs (miR)-21 on the expression of interleukin (IL)-10 in B cell of patients with Henoch-Schonlein purpura (HSP). From March 2016 to January 2017, twenty-four children with HSP hospitalized in rheumatology and immunology department of Shenzhen Children's Hospital were enrolled into the study, including 12 males and 12 females. Patients were divided into purpura nephritis group (HSPN, 14 cases) and non-nephritis group (NHSPN, 10 cases). Read More

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December 2018
1 Read

Drug Hypersensitivity Reactions Documented in Electronic Health Records within a Large Health System.

J Allergy Clin Immunol Pract 2018 Dec 1. Epub 2018 Dec 1.

Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Background: Hypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.

Objective: To examine HSR epidemiology using longitudinal EHR data from a large United States healthcare system. Read More

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December 2018
2 Reads

MEFV gene variants in children with Henoch-Schönlein Purpura and association with clinical manifestations: a single center Mediterranean experience.

Postgrad Med 2018 Dec 4. Epub 2018 Dec 4.

a Department of Pediatric Rheumatology , Cukurova University Faculty of Medicine , Adana , Turkey.

Objectives: Henoch Schönlein Purpura (HSP) is characterized by non-thrombocytopenic palpable purpura, abdominal pain and arthralgia/arthritis. We aimed to describe the clinical presentations of children with HSP in a single center and compare the prevalence of each manifestations between patients with MEFV variants, particularly in exon 10 and those without.

Methods: This cohort retrospectively included 144 HSP (59 females, 85 males) patients without FMF symptoms and followed for at least 6 months. Read More

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December 2018

Skin anti-inflammatory activity of rose petal extract () through reduction of MAPK signaling pathway.

Food Sci Nutr 2018 Nov 25;6(8):2560-2567. Epub 2018 Oct 25.

Korea Food Research Institute Wanju-gun Korea.

The aim of this study was to investigate the skin anti-inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The plant exerts various biological functions, including antioxidant and anti-microbiological activities. Read More

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November 2018
4 Reads

IgG4-related kidney disease and retroperitoneal fibrosis: An update.

Mod Rheumatol 2018 Nov 30:1-24. Epub 2018 Nov 30.

c Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine , Fukuoka University , Fukuoka , Japan.

The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter. Read More

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November 2018
4 Reads

Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study.

Clin Rheumatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Xicheng District, Beijing, 100044, China.

Objectives: The standard strategy for treating lupus nephritis comprises glucocorticoids together with either intravenous cyclophosphamide or oral mycophenolate mofetil, but the low remission rate is still a challenge in practice. This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy.

Method: A 24-week trial was conducted in 17 rheumatology or nephrology centers in China. Read More

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November 2018
1 Read

Response of Proliferative Lupus Nephritis with Pulse Cyclophosphamide Therapy during Induction Period: A Single Centre Study in Bangladesh.

Mymensingh Med J 2018 Oct;27(4):693-701

Dr Mohammad Bellal Hossain, Medical Officer, Department of Nephrology, Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh.

This prospective study was conducted to assess the response of proliferative lupus nephritis with pulse cyclophosphamide therapy during induction period in the department of Nephrology of Dhaka Medical College, Dhaka, Bangladesh from December 2012 to November 2013. A total of 35 clinically diagnosed SLE patients of class III/IV lupus nephritis were included. But 3 patients were dropped out during follow-up, therefore finally 32 patients (class III = 4, class IV = 28) were studied. Read More

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October 2018

A CD4 T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate.

Nat Med 2018 Nov 26. Epub 2018 Nov 26.

Baylor Institute for Immunology Research, Dallas, TX, USA.

Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE). Follicular helper T cells (T cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers. Read More

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November 2018
1 Read

IL-34 promotes foam cell formation by enhancing CD36 expression through p38 MAPK pathway.

Sci Rep 2018 Nov 26;8(1):17347. Epub 2018 Nov 26.

Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.

Atherosclerosis is characterized as a chronic inflammatory disease and macrophage-derived foam cells play a central role during the pathologic processes. A newly discovered cytokine interleukin-34 (IL-34) is closely associated with various inflammatory and autoimmune diseases. Expression of IL-34 in obesity, inflammatory bowel disease (IBD), rheumatoid arthritis (RA), lupus nephritis and coronary artery diseases (CAD) are significantly elevated. Read More

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November 2018
5 Reads

Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus.

Lupus 2018 Nov 26:961203318815577. Epub 2018 Nov 26.

1 Department of Medicine, Vanderbilt University Medical Center, Nashville, USA.

In systemic lupus erythematosus (SLE), dsDNA antibodies are associated with renal disease. Less is known about comorbidities in patients without dsDNA or other autoantibodies. Using an electronic health record (EHR) SLE cohort, we employed a phenome-wide association study (PheWAS) that scans across billing codes to compare comorbidities in SLE patients with and without autoantibodies. Read More

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November 2018
1 Read

De novo mutations in COL4A5 identified by whole exome sequencing in two girls with Alport syndrome in Korea.

Korean J Pediatr 2018 Nov 26. Epub 2018 Nov 26.

Green Cross Genome, Yongin, Korea, Gyeonggi-do, Korea.

Alport syndrome (ATS) is an inherited glomerular disease caused by mutations in one of the type IV collagen novel chains (α3, α4, and α5). ATS is characterized by persistent microscopic hematuria starting from infancy, eventually leading to either progressive nephritis or end-stage renal disease. There are three known genetic forms of ATS, i. Read More

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November 2018
2 Reads

Comprehensive longitudinal surveillance of the IgG autoantibody repertoire in established systemic lupus erythematosus.

Arthritis Rheumatol 2018 Nov 26. Epub 2018 Nov 26.

Hiller Research Center Rheumatology at University Hospital Düsseldorf, Medical Faculty, Heinrich-Heine-University, Merowingerplatz 1a, 40225, Düsseldorf.

Objective: to appraise the role of epitope spreading in established human systemic lupus erythematosus (SLE).

Methods: IgG-autoantibody reactivity to 398 distinct recombinant proteins was measured in 69 SLE patients over 6 years and compared to 45 controls. Changes in mean fluorescence intensity (MFI), number of autoantibodies to distinct antigens, and reactivity to distinct clones of selected established antigenic targets U1-RNP, Sm, and ribosomal P representing epitope fine mapping were assessed. Read More

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November 2018
2 Reads

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis.

J Cell Biochem 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Objective: This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in the treatment of tinnitus for patients with chronic nephritis.

Methods: A total of 89 adult patients were diagnosed with chronic glomerulonephritis from January 2016 to December 2017. All the patients were randomly divided into two groups, such as the control group and the CYG group. Read More

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November 2018
1 Read
3.263 Impact Factor

Isolation and genomic characterization of a novel chicken-orign orthoreovirus causing goslings hepatitis.

Vet Microbiol 2018 Dec 25;227:69-77. Epub 2018 Oct 25.

College of Animal Science and Technology, Shandong Agricultural University, 61 Daizong Street, Tai'an, Shandong Province, 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai'an, Shandong, 271018, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong, 271018, China. Electronic address:

A severe infectious disease characterized by nephritis, hepatitis and splenitis has attacked goslings around Shandong province in China since 2016. A novel chicken-origin avian orthoreovirus (ARV) was isolated with LMH cells from affected goslings named Reo/Goose/SDPY/1116/17 (SDPY-ARV) strain, and the infection was successfully reproduced experimentally. The ARV-SDPY full genome sequencing was conducted using Next-Generation Sequencing (NGS) technique on Illumina HiSeq platform. Read More

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December 2018
1 Read

The role of microbiota in the pathogenesis of lupus: Dose it impact lupus nephritis?

Pharmacol Res 2018 Nov 22;139:191-198. Epub 2018 Nov 22.

Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Systemic lupus erythematosus (SLE) is a complex, inflammatory, and autoimmune disease triggered by complicated interactions of different factors. A major contributor to morbidity and mortality in SLE is lupus nephritis (LN). To date, the cause of SLE and LN is incompletely understood but a combination of genetic and environmental factors is thought to be involved. Read More

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November 2018
6 Reads
4.408 Impact Factor

CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus.

Sci Rep 2018 Nov 23;8(1):17297. Epub 2018 Nov 23.

Transplantation Research Center, Samsung Biomedical Research Institute, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with an unknown etiology. Recently, it has been elucidated that dysregulated histone deacetylase (HDAC) activity is related to the pathogenesis of inflammatory and autoimmune diseases. Broad-spectrum HDAC inhibitors are effective for the treatment of allergy, cancer, and autoimmune diseases, but they have several adverse side effects. Read More

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November 2018
6 Reads

Clinical markers to predict progression from acute to chronic kidney disease in Mesoamerican nephropathy.

Kidney Int 2018 Dec;94(6):1205-1216

Section of Pediatric Tropical Medicine, Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas, USA. Electronic address:

An epidemic of chronic kidney disease (CKD) of unknown etiology, known as Mesoamerican Nephropathy (MeN), has been ongoing in Latin America for at least two decades. MeN primarily affects young adults without traditional CKD risk factors, and agricultural workers are disproportionately afflicted. We previously identified an acute phase of MeN that involves acute kidney injury (AKI) with tubulointerstitial nephritis and systemic inflammation. Read More

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December 2018
2 Reads

Extracellular traps in kidney disease.

Kidney Int 2018 Dec;94(6):1087-1098

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany. Electronic address:

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent. Read More

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December 2018
4 Reads

Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.

BMC Nephrol 2018 Nov 22;19(1):334. Epub 2018 Nov 22.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, People's Republic of China.

Background: IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a type of systemic vasculitis. This study aimed to explore the clinicopathological features, treatment and renal outcomes of adult IgAV-related nephritis (Henoch-Schönlein purpura nephritis) patients with different degrees of crescent formation.

Methods: Adult patients with biopsy-proven IgAV-related nephritis in Nanjing Jinling Hospital were enrolled and divided into three groups as follows: control (no crescents, n = 257), group 1 (crescents < 25%, n = 381), and group 2 (crescents ≥25%, n = 60). Read More

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November 2018
1 Read

Pediatric lupus nephritis.

J Bras Nefrol 2018 Nov 14. Epub 2018 Nov 14.

Universidade Federal de Minas Gerais, Hospital das Clínicas, Unidade de Nefrologia Pediátrica, Belo Horizonte, MG, Brasil.

Involvement of the kidneys by lupus nephritis (LN) is one of the most severe clinical manifestations seen in individuals with systemic lupus erythematosus (SLE). LN is more frequent and severe in pediatric patients and has been associated with higher morbidity and mortality rates. This narrative review aimed to describe the general aspects of LN and its particularities when affecting children and adolescents, while focusing on the disease's etiopathogenesis, clinical manifestations, renal tissue alterations, and treatment options. Read More

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November 2018
2 Reads

Comparing the 1997 update of the 1982 American College of Rheumatology (ACR-97) and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria for systemic lupus erythematosus (SLE) classification: which enables earlier classification of SLE in an urban Asian population?

Lupus 2018 Nov 21:961203318811599. Epub 2018 Nov 21.

1 Duke-NUS Medical School, Singapore.

Objective: We compared the 1997 update of the 1982 American College of Rheumatology (ACR-97) and the 2012 Systemic Lupus International Collaborating Clinics (SLICC-12) criteria, for earlier classification of systemic lupus erythematosus (SLE) in a multiethnic urban Asian SLE population.

Methods: Patients from a retrospective, nested case-control study of the influence of lupus nephritis on mortality in SLE were studied. For each patient, dates of first manifestations of each criteria (both ACR-97 and SLICC-12) were recorded, and the date of disease classification using ACR-97 or SLICC-12 criteria was compared to determine which criteria resulted in earlier classification. Read More

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November 2018
2 Reads

The Jakinibs in systemic lupus erythematosus: progress and prospects.

Authors:
Chi Chiu Mok

Expert Opin Investig Drugs 2018 Nov 21:1-8. Epub 2018 Nov 21.

a Department of Medicine , Tuen Mun Hospital , Hong Kong , SAR China.

Introduction: Multiple pathways are involved in the pathogenesis of systemic lupus erythematosus (SLE). The Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway mediates the intracellular signals of more than 60 cytokines, growth factors and hormones from the type I/II cytokine receptors. Dysregulation of the cytokines is a hallmark of SLE; inhibition of downstream signaling mediated by the JAKs is an attractive therapeutic option. Read More

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November 2018
6 Reads

Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses.

Ann Rheum Dis 2018 Nov 20. Epub 2018 Nov 20.

Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, USA

Objective: Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) VIB9600 (previously known as MEDI9600) that blocks IgG immune complex-mediated cellular activation for clinical development.

Methods: VIB9600 was humanised and optimised from the IV. Read More

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November 2018
1 Read

An IgA1-lambda-type monoclonal immunoglobulin deposition disease associated with membranous features in a patient with IgG4-related kidney disease: a case report.

BMC Nephrol 2018 Nov 20;19(1):330. Epub 2018 Nov 20.

Department of Nephrology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minamikoshigaya, Koshigaya, Saitama, 343-8555, Japan.

Background: IgG4-related disease (IgG4-RD) is a newly recognized fibroinflammatory condition. The kidney is one of the organs commonly affected by IgG4-RD. Tubulointerstitial nephritis (TIN) is the main feature, and membranous nephropathy (MN) has also been described frequently. Read More

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November 2018
7 Reads

Systemic lupus erythematosus among male patients in Malaysia: how are we different from other geographical regions?

Lupus 2018 Nov 20:961203318812676. Epub 2018 Nov 20.

5 Department of Immunology and Microbiology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur.

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease which predominantly affects females. The disease characteristics in male SLE patients are reported to be distinct and may vary across ethnicities and geographical regions.

Objective: To determine and compare the clinical phenotype and organ damage between male and female patients with SLE in Malaysia. Read More

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November 2018
4 Reads

Increased susceptibility against Cryptococcus neoformans of lupus mouse models (pristane-induction and FcGRIIb deficiency) is associated with activated macrophage, regardless of genetic background.

J Microbiol 2018 Nov 19. Epub 2018 Nov 19.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The severity of cryptococcosis in lupus from varying geneticbackgrounds might be different due to the heterogeneity of lupus-pathogenesis. This study explored cryptococcosis in lupus mouse models of pristane-induction (normal geneticbackground) and FcGRIIb deficiency (genetic defect). Because the severity of lupus nephritis, as determined by proteinuria and serum creatinine, between pristane and FcGRIIb-/- mice were similar at 6-month-old, Cryptococcus neoformans was intravenously administered in 6-month-old mice and were age-matched with wild-type. Read More

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November 2018
1 Read

Not all inflammation in a renal allograft is rejection.

Clin Case Rep 2018 Nov 23;6(11):2285-2286. Epub 2018 Sep 23.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

High index of suspicion for adenovirus infection is required in renal graft dysfunction, especially in the setting of hematuria. Histology can mimic acute rejection, which creates a diagnostic dilemma. Tissue adenovirus immunostains, though usually reliable, may not be always positive like in our case. Read More

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November 2018
5 Reads

Lupus Nephritis.

Pediatr Clin North Am 2019 Feb;66(1):87-99

Department of Pathology and Immunology, Baylor College of Medicine, Texas Children's Hospital, 6621 Fannin Street, Suite AB195, Houston, TX 77030, USA.

Childhood-onset systemic lupus erythematosus (SLE) is a subset of SLE with an onset before 18 years of age. Patients with early onset SLE tend to have a greater genetic component to their disease cause, more multisystemic involvement, and a more severe disease course, which includes greater risks for developing nephritis and end-stage kidney disease. Five- and 10-year mortality is lower than in adult-onset SLE. Read More

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February 2019
6 Reads

Tubulointerstitial Nephritis.

Pediatr Clin North Am 2019 Feb;66(1):111-119

Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA.

Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. Read More

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February 2019
8 Reads

Immunoglobulin A Nephropathy and Immunoglobulin A Vasculitis.

Pediatr Clin North Am 2019 Feb;66(1):101-110

Department of Pediatrics, Medical University of South Carolina, 96 Jonathan Lucas Street, 428 CSB, MSC 608, Charleston, SC 29425, USA. Electronic address:

Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are common glomerulopathies in the pediatric population that deserve special attention. In some cases the primary care provider can follow the patient but others need more intensive management. Delaying this treatment can lead to worse morbidity. Read More

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February 2019
1 Read

NLRC5: potential novel non-invasive biomarker for predicting and reflecting the progression of IgA nephritis.

J Transl Med 2018 Nov 19;16(1):317. Epub 2018 Nov 19.

Department of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Kaifu District, Changsha, 410008, Hunan, China.

Background: The nucleotide oligomerization domain-like receptor subfamily C5 (NLRC5) is primarily expressed in the adaptive and innate immune systems. NLRC5 was recently discovered to regulate immunity and inflammatory responses. Abnormal immune and inflammatory responses are considered critical pathogenesis in IgA nephritis (IgAN). Read More

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November 2018

Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus.

Lupus 2018 Nov 19:961203318812679. Epub 2018 Nov 19.

1 Grupo de Nefrología, Universidad Simón Bolívar, Barranquilla, Colombia.

Background: Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune disorder characterized by an exacerbated expression of cytokines and chemokines in different tissues and organs. Renal involvement is a significant contributor to the morbidity and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy, an invasive procedure with a high risk of complications. Therefore, the development of alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus erythematosus is a priority. Read More

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November 2018
5 Reads

Update on Lupus Nephritis for GPs.

Authors:
M McClure R Jones

Lupus 2018 Oct;27(1_suppl):11-14

Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge.

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October 2018
1 Read

Infections in newly diagnosed Spanish patients with systemic lupus erythematosus: data from the RELES cohort.

Lupus 2018 Dec;27(14):2253-2261

1 Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain.

Objectives: Using data of patients from the inception cohort Registro Español de Lupus Eritematoso Sistémico (RELES), we aimed to analyse the incidence of severe infection in the first two years of follow-up and how predictors of infection change during the course of systemic lupus erythematosus (SLE).

Material And Methods: The study included 282 patients. Markers of lupus activity, prednisone doses and immunosuppressive therapy were compared between patients with and without infections in the first and second year of the disease. Read More

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December 2018
3 Reads

A Case of Systemic Sarcoidosis Presenting with Renal Involvement Caused by Various Sarcoidosis-associated Pathophysiological Conditions.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Nephrology, Graduate School of Biomedical Sciences, Tokushima University, Japan.

A 61-year-old man was diagnosed with sarcoidosis involving the lungs, eyes, parotid gland and extrathoracic lymph nodes complicated by chronic kidney injury and hypercalcemia. Kidney biopsy showed non-specific interstitial nephritis and nephrosclerosis. However, immunohistochemical staining of cell surface markers revealed a multinucleated giant macrophage surrounded by T-cells, suggesting granulomatous interstitial nephritis. Read More

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November 2018
5 Reads

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases.

Mol Immunol 2018 Dec 15;104:90-99. Epub 2018 Nov 15.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Section of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4 T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4 T cell subset named T17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Read More

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December 2018
2 Reads

Late-onset biopsy-proven lupus nephritis without other associated autoimmune diseases: severity and long-term outcome.

Lupus 2018 Nov 15:961203318811603. Epub 2018 Nov 15.

1 Department of Rheumatology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Background/purpose: Lupus nephritis (LN) usually develops within the first years of systemic lupus erythematosus (SLE) onset and rarely after that. There are scarce studies comparing early- versus late-onset nephritis (before versus after five years of SLE diagnosis). The aim of this study was to compare the severity and long-term outcome (after 7 years) in these two, late-onset and early-onset, nephritis groups. Read More

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November 2018
4 Reads

Expression of CMIP in podocytes is restricted to specific classes of lupus nephritis.

PLoS One 2018 15;13(11):e0207066. Epub 2018 Nov 15.

AP-HP (Assistance Publique des Hôpitaux de Paris), Groupe Hospitalier Henri-Mondor, Department of Nephrology and Renal Transplantation, Créteil, France.

Lupus glomerulopathies are classified into various histological patterns, which probably result from different pathophysiological origins. Podocyte injury can be demonstrated in lupus nephritis but its clinical relevance is far little appreciated and is often masked by proliferative lesions and inflammatory cell infiltrations. Two patterns of podocyte lesions may be considered, either occurring in the context of renal inflammation or reflecting podocyte dysfunction in non-proliferative and non-inflammatory glomerulopathies. Read More

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November 2018
5 Reads

Immunoglobulin G subclass 3 in ISN/RPL lupus nephritis classification
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Clin Nephrol 2018 Nov 15. Epub 2018 Nov 15.

Objectives: In lupus nephritis, the immune complex plays a very important role in kidney disease progression, and immunoglobulin G subclass 3 (IgG3) may play an important role in endothelial damage as lupus nephropathy progresses. We evaluated the association between IgG3 positivity and lupus nephritis activity.

Materials And Methods: We identified 71 biopsies taken from 57 patients who had lupus nephritis with enough tissue to allow light and immunofluorescence microscopy. Read More

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November 2018
3 Reads

Pharmacokinetics of free and total mycophenolic acid in adult lupus nephritis patients-implications for therapeutic drug monitoring.

Eur J Clin Pharmacol 2018 Nov 14. Epub 2018 Nov 14.

Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211a, 50-556, Wrocław, Poland.

Purpose: To evaluate the relationship between total and free MPA pharmacokinetic (PK) parameters and renal outcome markers, and to verify whether conducting therapeutic drug monitoring (TDM) in lupus nephritis (LN) patients would be of value in routine clinical practice.

Methods: Eighty-four samples were collected from sixteen LN patients. Total and free MPA concentrations were measured at predose, 0. Read More

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November 2018
2 Reads

Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature.

Pediatr Rheumatol Online J 2018 Nov 14;16(1):71. Epub 2018 Nov 14.

Department of Pediatrics, Division of Rheumatology, University of Alabama at Birmingham, 1600 7th Ave S, CPPN G10, Birmingham, AL, 35233, USA.

Background: Henoch-Schonlein purpura (HSP) is a small vessel vasculitis that is characterized by non-thrombocytopenic purpura, abdominal pain, arthritis, and glomerulonephritis. Typically, HSP is self-limited requiring only supportive care, but more severe cases may require corticosteroid (CS) treatment. Rarely, a subset of these patients has persistent rash, arthritis, abdominal involvement, or renal disease despite treatment with CS, or has disease recurrence on CS tapering. Read More

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November 2018
9 Reads

Oral acyclovir induced hypokalemia and acute tubular necrosis a case report.

BMC Nephrol 2018 Nov 14;19(1):324. Epub 2018 Nov 14.

Servicio de Nefrología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Acyclovir is one of the most common prescribed antiviral drugs. Acyclovir nephrotoxicity occurs in approximately 12-48% of cases. It can present in clinical practice as acute kidney injury (AKI), crystal-induced nephropathy, acute tubulointerstitial nephritis, and rarely, as tubular dysfunction. Read More

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November 2018
2 Reads