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Cardiorenal Med 2019 Apr 17;9(4):212-221. Epub 2019 Apr 17.

Kidney Disease Branch, NIDDK, Bethesda, Maryland, USA,

Background: Observational studies show that African American (AA) dialysis patients have longer survival than European Americans. We hypothesized that apolipoprotein L1 (APOL1) genetic variation, associated with nephropathy in AAs, contributes to the survival advantage in AA dialysis patients.

Methods: We examined the association between race and mortality among 37,097 adult dialysis patients, including 54% AAs and 46% European Americans from a large dialysis organization (entry period from July 2001 to June 2006, follow-up through June 2007), within each cause of end-stage renal disease (ESRD) category associated with APOL1 renal risk variants using Cox proportional hazard models. Read More

Chemotherapy 2019 Apr 9;63(6):345-351. Epub 2019 Apr 9.

University of Minnesota College of Pharmacy, Minneapolis, Minnesota, USA,

Background: Antistaphylococcal penicillins have historically been regarded as the drugs of choice for methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). However, recent outcomes data compared to cefazolin treatment are conflicting.

Objective: This study compared treatment failure and adverse effects associated with nafcillin and cefazolin for MSSA BSI. Read More

Mod Pathol 2019 Apr 8. Epub 2019 Apr 8.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Renal biopsy is the gold standard for diagnosis of membranous nephropathy. Circulating PLAR1 antibody found in 75% of patients with membranous nephropathy is very specific for the diagnosis of this disease. Therefore, the question arises whether PLAR1-antibody-positive patients still need a diagnostic renal biopsy. Read More

Ren Fail 2019 Nov;41(1):204-210

b Department of Internal Medicine , Changwon Gyeongsang National University Hospital , Changwon , Republic of Korea.

Acute kidney injury (AKI) associated with acute pyelonephritis (APN) rarely has been reported. The aim of this study was to evaluate the incidence and risk factors of AKI associated with APN. We retrospectively reviewed the medical records of 403 patients over 18-year old age hospitalized for APN management from October 2009 to September 2014 in tertiary care referral center. Read More

Presse Med 2019 Mar 26. Epub 2019 Mar 26.

Assistance publique Hôpitaux de Paris (AP-HP), hôpital Cochin, service de gastroentérologie, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris-Descartes, 12, rue de l'École de médecine, 75006 Paris, France. Electronic address:

Proton pump inhibitors (PPIs) are among the most prescribed drugs in the world. While their efficacy in acute management is indisputable, it has long been suggested that PPI therapy is safe in the long term. In recent years, there has been growing and justified concern about the long-term risks of PPIs. Read More

J Immunol Res 2019 17;2019:3952392. Epub 2019 Feb 17.

Division of Nephrology, Department of Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.

Objective: A retrospective analysis of clinical characteristics and immunological manifestations of primary Sjogren's syndrome (pSS) patients with or without renal involvement was conducted in order to elucidate the potential risk factors of renal damage in pSS and evaluate the condition.

Methods: A total of 1002 patients, who fulfilled the 2002 classification criteria for pSS from the Second Affiliated Hospital of Shanxi Medical University, were enrolled in the cross-sectional study. Clinical, immunological, and histological characteristics were compared between pSS patients with and without renal involvement, and potential risk factors of renal involvements in pSS patients were examined by multivariate analysis. Read More

Oncologist 2019 Mar 22. Epub 2019 Mar 22.

Division of Oncology, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies directed at negative regulatory components on T cells, such as cytotoxic T lymphocyte-associated antigen 4, programmed cell death-1 (PD-1), and its ligand, programmed cell death ligand-1. ICIs initate antitumor immunity; however, these agents are associated with immune-related adverse events (irAEs) that may affect a variety of organs. Renal irAEs most commonly present with asymptomatic acute kidney injury (AKI), which is often detected by routine laboratory testing. Read More

J Comp Pathol 2019 Feb 7;167:26-31. Epub 2019 Jan 7.

Departamento de Medicina Veterinária, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s/n, Dois Irmãos, Recife, Brazil. Electronic address:

The aim of this study was to evaluate the histopathological changes in the urinary system and their correlation with serum biochemical parameters, parasite load and immunodetection of amastigotes in 30 dogs infected naturally by Leishmania infantum. The major histological changes were glomerulonephritis and interstitial nephritis. Serum biochemistry demonstrated that the dogs had progressive loss of renal function. Read More

Clin Exp Nephrol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pediatric Nephrology, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Background: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. The long-term prognosis is variable and depends on renal involvement. The aims of this study were to investigate the clinical and laboratory characteristics of our HSP patients, to identify the risk factors for the development of Henoch-Schönlein purpura nephritis (HSPN) and to assess the efficacy of the Oxford Classification system for predicting renal outcomes. Read More

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

Urol J 2019 Mar 18. Epub 2019 Mar 18.

Department of Nephrology, Xijing Hospital, Xi'an, Shaanxi 7100032,China.

Primary renal lymphoma(PRL) is an extremely rare form of extranodal lymphoma andexhibitsas single (10-20%), multifocal nodules (60%), renal invasion from contiguous retroperitoneal disease (25-30%), diffuse infiltration (20%) or perirenal involvement (10%)[1] .Here we report a case of bilateral primary renal lymphoma in a 13 year-old boy who presented with homogenous nephromegaly and acute interstitial nephritis(AIN).The renal biopsy revealed primary renal T lymphoblastic lymphoma. Read More

Toxicon 2019 Mar 14;163:1-7. Epub 2019 Mar 14.

Department of Nephrology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, 441000, Hubei, China. Electronic address:

Stinging accidents involving wasp venom are a notable cause of acute kidney injury (AKI) in Asia. However, very little attention has been paid to the understanding of the mechanisms involved in this type of AKI. The aims of this review are to explore the evidence for the mechanisms and the therapeutic role of renal replacement therapy of wasp venom and AKI. Read More

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address:

In older adults, the most common kidney biopsy diagnoses include pauci-immune crescentic glomerulonephritis, membranous nephropathy, and focal segmental glomerulosclerosis. Recently, investigators described a small series of older patients (aged 66-80 years) with acute kidney injury and a kidney biopsy demonstrating tubular basement membrane (TBM) immune deposits of polytypic immunoglobulin G (IgG) and C3, acute tubular injury, and tubulointerstitial inflammation. They identified a circulating antibody against kidney tubular low-density lipoprotein (LDL) receptor-related protein 2 (LRP2; also known as megalin) in patients' sera and colocalization of LRP2 with IgG in TBM deposits. Read More

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

CEN Case Rep 2019 Mar 2. Epub 2019 Mar 2.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, 216-8511, Japan.

Oxaliplatin, a third-generation platinum agent, has been used for the treatment of colon, pancreatic, and stomach cancers in recent years. It carries a reduced risk of acute kidney injury (AKI) compared to the previous platinum agents, including cisplatin and carboplatin. Several cases of oxaliplatin-induced acute tubular necrosis (ATN) have been reported; however, only one case has been reported as acute tubulointerstitial nephritis (ATIN) histopathologically. Read More

Malar J 2019 Mar 1;18(1):58. Epub 2019 Mar 1.

Department of Nephrology, University College Hospital, Galway, Republic of Ireland.

Background: Malarial acute renal failure (MARF) is a component of the severe malaria syndrome, and complicates 1-5% of malaria infections. This form of renal failure has not been well characterized by histopathology.

Case Presentation: A 44 year-old male presented to the emergency department with a 5-day history of fever and malaise after returning from Nigeria. Read More

Pediatr Nephrol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, Canada.

More than 250 drugs carry a small but important dose-independent risk of initiating a delayed-type hypersensitivity reaction that leads to acute tubulointerstitial nephritis (TIN). Clinical manifestations are often non-specific, making epidemiological studies challenging. In severe cases, if cessation of the offending drug is not followed by a prompt improvement in renal function, corticosteroid therapy appears to enhance renal recovery rates. Read More

Indian J Nephrol 2019 Jan-Feb;29(1):50-52

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Monoclonal gammopathy of undetermined significance does not have end organ damage, but a proportion of cases manifest with renal injury when it is called monoclonal gammopathy of renal significance (MGRS). Herein, we describe a case of acute hepatitis E infection, which precipitated the development of MGRS. The patient underwent kidney biopsy for elevated creatinine with clinical suspicion of drug-induced interstitial nephritis. Read More

Int J Rheum Dis 2019 Feb 27. Epub 2019 Feb 27.

Division of Rheumatology, Department of Internal Medicine, Chonnam National University Medical School & Hospital, Gwangju, Korea.

Aim: The aim of this study was to define clinical, histopathologic, and prognostic differences according to the presence of anti-ribosomal P antibody (anti-P) in Korean patients with biopsy-proven lupus nephritis (LN).

Methods: We studied 79 patients who underwent kidney biopsies prior to the start of induction treatment, and who were subsequently treated with immunosuppressive drugs for at least 6 months and followed-up for more than 6 months. Anti-P was measured by immunoblot analysis at the time of renal biopsy. Read More

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):231-234

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Snake bite envenomation is common in tropical countries during the summer. Snake bite-induced acute kidney injury (AKI) has varied histopathological manifestations such as acute cortical necrosis, acute tubular necrosis (ATN), and acute interstitial nephritis. However, snake bite-induced renal medullary angiitis has rarely been reported. Read More

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):157-165

Department of Nephrology, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.

Drug-induced acute interstitial nephritis (DIAIN) is a common cause of acute deterioration of renal function. Early diagnosis and discontinuation of the offending drug usually lead to recovery of renal function. Steroid administration further hastens the recovery. Read More

Rev Prat 2018 Feb;68(2):170-174

Service de néphrologie, hôpital européen Georges-Pompidou, AP-HP, faculté de médecine Paris-Descartes, Paris, France.

Acute interstital nephritis. Acute interstitial nephritis represents 10 to 30% of all biopsy-proven acute kidney injury cases. This disease is characterised by infiltration of renal interstitial tissue by in- flammatory cells, leading to oedema, tubulopathy and subsequent fibrotic lesions. Read More

J Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

Q Li, Department of Endocrine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Bisphenol-A (BPA) is a common environmental pollutant, and exposure to it is associated with proteinuria and may predict the progression of chronic kidney disease，however, the mechanism is not clear. Neutrophil extracellular traps (NETs) is a DNA skeleton coated with various proteases, and it is associated with various autoimmune nephritis. In this study, we examine whether NETs is involved in BPA-induced chronic kidney injury. Read More

Case Rep Nephrol 2019 15;2019:3614980. Epub 2019 Jan 15.

Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Immune-checkpoint-inhibitors (ICPIs) represent a novel class of immunotherapy against several malignancies. These agents are associated with several "immune-mediated" adverse effects, but the reported renal toxicity of ICPIs is less well defined. We present the case of a 60-year-old man with a history of non-small cell lung cancer, who developed acute kidney injury (AKI) approximately 3. Read More

Am J Case Rep 2019 Feb 18;20:212-218. Epub 2019 Feb 18.

Department of Internal Medicine, Mount Sinai Hospital, Chicago, IL, USA.

BACKGROUND The hallmark of bullous pemphigoid (BP) is widespread tense blisters arising on normal or erythematous skin, often with marked pruritus, the diagnosis of which is confirmed by direct immunofluorescence (DIF). BP is an autoimmune process that can be induced, though rarely, by medications. Drug-induced BP often has atypical clinical presentation, which requires a good understanding of other dermatological conditions with similar presentations, in particular, bullous subtype of erythema multiforme. Read More

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

Clin Kidney J 2019 Feb 9;12(1):81-88. Epub 2018 Nov 9.

Department of Pathology, Pitie-Salpetriere Hospital, Paris, France.

Objective: Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to describe the clinic-biological and histopathological characteristics of pembrolizumab-related nephropathy and its response to treatment. Read More

Clin Kidney J 2019 Feb 1;12(1):78-80. Epub 2018 Dec 1.

Department of Microbiology and Immunology, Laboratory of Experimental Transplantation, KU Leuven, Leuven, Belgium.

Checkpoint inhibitors are increasingly used to treat different types of malignancy and have been associated with renal toxicities. In this issue, Izzedine report on the incidence of pembrolizumab-associated renal toxicity in a French single-centre nephrology referral centre. They report an estimated incidence of pembrolizumab-related renal toxicities of 1. Read More

Int J Clin Pharmacol Ther 2019 May;57(5):264-269

Background: There are many side effects of antituberculous drugs, however, renal failure is relatively rare. Therefore, this side effect is thought to be unrecognized by most physicians. We experienced one case of acute renal failure caused by antituberculous therapy (rifampicin). Read More

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, University of California, San Francisco, San Francisco, CA. Electronic address:

Background: While hypersensitivity reactions are well-characterized for certain medications, vancomycin-associated drug-induced hypersensitivity syndrome (DIHS), or drug reaction with eosinophilia and systemic symptoms (DRESS), has yet to be defined.

Objective: To better define the clinical phenotype of vancomycin-associated DIHS.

Methods: A retrospective case series was conducted over an 8-year period at a single, academic institution. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14428

Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, China.

Rationale: Angiotensin receptor blocker (ARB) can increase serum creatinine or potassium levels in patients with renal insufficiency, renal artery stenosis, heart failure or hypovolemia, but hardly cause severe kidney injury in patients without any risk factors. A case of severe acute interstitial nephritis (AIN) induced by valsartan was reported here.

Patient Concerns: A 62-year-old female with nausea for 1 month and acute deterioration of kidney function for 2 weeks was admitted. Read More

Arthritis Res Ther 2019 Jan 29;21(1):40. Epub 2019 Jan 29.

Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Background: Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE) and is characterized by glomerulosclerosis, interstitial fibrosis, and tubular atrophy, along with severe persistent proteinuria. DZ2002 is a reversible S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor with potent therapeutic activity against lupus nephritis in mice. However, the molecular events underlying the renal protective effects of DZ2002 remained unclear. Read More

Clin Nephrol 2019 Jan 28. Epub 2019 Jan 28.

Transbound Emerg Dis 2019 Jan 26. Epub 2019 Jan 26.

Unidad Mixta Pasteur + INIA (UMPI), Institut Pasteur de Montevideo, Montevideo, Uruguay.

Acute leptospirosis is an infrequent disease in sheep that can cause jaundice, haemolysis, haemoglobinuria, hepatitis and nephritis. In most reports the diagnoses have been made by clinical, pathological or serological evidence without isolation or direct identification of the agent. Here, we report one confirmed and one presumptive outbreak of acute leptospirosis in suckling lambs from two unrelated sheep farms in Uruguay with mortalities of 9/60 (15%) and 9/163 (5. Read More

Kidney Int 2019 Feb;95(2):429-438

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Kidney biopsy is the gold standard to diagnose membranous nephropathy (MN). Approximately 70%-80% of patients with primary MN have anti-phospholipase A2 receptor (PLA2R) antibodies. We hypothesized that PLA2R antibody testing without kidney biopsy may be a valid strategy to make a non-invasive diagnosis of MN in patients with a negative work-up for secondary causes. Read More

Nephrology (Carlton) 2019 Jan 20. Epub 2019 Jan 20.

Department of Nephrology and Hypertension, Groote Schuur Hospital, University of Cape Town, Western Cape, South Africa.

Introduction: South Africa continues to be burdened by human immunodeficiency virus [HIV] and tuberculosis [TB]. In Cape Town, the epidemic of HIV-TB co-infection is as high as 70%. Granulomatous interstitial nephritis [GIN] has increased in frequency on renal biopsy. Read More

Clin J Am Soc Nephrol 2019 Jan 18. Epub 2019 Jan 18.

Kandy Teaching Hospital, Kandy, Sri Lanka.

Background And Objectives: A kidney disease of unknown cause is common in Sri Lanka's lowland (dry) region. Detailed clinical characterizations of patients with biopsy-proven disease are limited, and there is no current consensus on criteria for a noninvasive diagnosis.

Design, Setting, Participants, & Measurements: We designed a prospective study in a major Sri Lankan hospital servicing endemic areas to ascertain pathologic and clinical characteristics of and assess risk factors for primary tubulointerstitial kidney disease. Read More

BMC Nephrol 2019 Jan 16;20(1):22. Epub 2019 Jan 16.

Department of Nephrology, Serdang Hospital, 43400, Seri Kembangan, Selangor, Malaysia.

Background: Although there is a large volume of literature regarding the definition and epidemiology of. Type 2 diabetes nephropathy (T2DN). There has been a paucity of data focused on the rate of transition of T2 DN. Read More

J Radiol Case Rep 2018 Nov 30;12(11):18-24. Epub 2018 Nov 30.

Department of Urology, Hospital Universitario Sanitas La Moraleja, Universidad Francisco de Vitoria, Madrid, Spain.

Xanthogranulomatous pyelonephritis is a rare form of chronic pyelonephritis in which the involved areas of the kidneys are destroyed and replaced by foam cells. It usually occurs in immunocompromised middle-aged females with ureteral obstruction or chronic urinary tract infection induced by the formation of renal stones. We herein report the case of a 44-year-old woman, with a history of left kidney staghorn calculi and recurrent urinary tract infections. Read More

Indian J Nephrol 2018 Nov-Dec;28(6):477-481

Laboratory of Pathology Souss, Agadir, Morocco.

Allopurinol-induced drug reactions with eosinophilia and systemic symptoms (DRESS) is a severe illness related to hypersensitivity syndrome characterized by fever, skin rash, lymph node enlargement, hematological abnormalities, especially eosinophilia and atypical lymphocytosis, and single or multiple organ involvement. The syndrome is difficult to diagnose in view of its clinical heterogeneity and long latency period within 8 weeks after start treatment. We report a case of DRESS syndrome in a 64-year-old man, induced by allopurinol treatment for asymptomatic hyperuricemia, started 8 weeks earlier but stopped only 3 days after because of the onset of rash. Read More

Int J Pediatr 2018 16;2018:9256528. Epub 2018 Dec 16.

College of Pharmacy, King Saud Bin Abdul-Aziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Vancomycin and piperacillin-tazobactam (PTZ) are commonly used as empirical therapy for patients with health care associated infections. Vancomycin has been recognized as a nephrotoxic agent and in a few cases in the literature PTZ has been associated with interstitial nephritis nevertheless; the combination of these agents has routinely been used for many years. However, there have been some observational studies that showed high rates of acute kidney injury (AKI) in patients receiving vancomycin and PTZ concomitant treatment compared to patients receiving vancomycin alone. Read More

Geriatr Gerontol Int 2019 Mar 8;19(3):259-264. Epub 2019 Jan 8.

Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

Aim: Neutrophil extracellular traps play key roles in the necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the relationships between neutrophil extracellular traps formation and the distribution and phase of vasculitis are not well understood. In the present study, we clarified the clinicopathological characteristics of older AAV patients, as well as the expression of citrullinated histone H3 (citH3), a marker of neutrophil extracellular traps, in autopsied AAV patients. Read More

Kidney Res Clin Pract 2018 Dec 31;37(4):347-355. Epub 2018 Dec 31.

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.

Background: Nephrotic syndrome (NS) is the most common glomerulopathy in children. Acute kidney injury (AKI) is a common complication of NS, caused by severe intravascular volume depletion, acute tubular necrosis, interstitial nephritis, or progression of NS. However, the incidence and risk factors of childhood-onset NS in Korea are unclear. Read More

Clin Nephrol 2019 Mar;91(3):187-191

Telavancin is a lipoglycopeptide semi-synthetic derivative of vancomycin used for select infections caused by Gram-positive bacteria including . Human clinical trials suggest that telavancin is potentially nephrotoxic, however there is no histopathologic description of acute kidney injury (AKI) in humans. An animal model has recently characterized the histologic changes associated with telavancin-induced AKI as proximal tubular injury with numerous phagolysosomes. Read More

J Immunother Cancer 2019 Jan 6;7(1). Epub 2019 Jan 6.

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1468, Houston, TX, 77030, USA.

Rationale & Objective: The approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents. The literature on the nephrotoxicity of CPI is limited. Here, we present cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects. Read More

BMC Vet Res 2019 Jan 5;15(1). Epub 2019 Jan 5.

Department of Virology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.

Background: The diagnosis of previous cases of feline tuberculosis in Turkey has been made based solely on pathological changes without isolation of the causative agent. This case report details the first case of feline tuberculosis in Turkey for which the causative agent (Mycobacterium bovis) was confirmed with microbiological isolation, morphological evaluation, molecular (PCR) characterization and antibiotic sensitivity.

Case Presentation: Systemic tuberculosis was diagnosed via postmortem examination of a 5-year-old stray male cat. Read More

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1366-1370

Department of Histopathology, Sir Ganga Ram Hospital, New Delhi, India.

BK virus is a polyoma virus which remains in latent phase in the urinary tract, particularly in the renal tubular epithelial cells. In immunosuppressed patients, it is activated and manifests as tubule-interstitial nephritis causing renal allograft dysfunction. A total of 402 patients who underwent renal allograft biopsy from 2013 to 2016 were included in this study; six patients were diagnosed to have BK virus nephropathy. Read More

Ann Hepatobiliary Pancreat Surg 2018 Nov 27;22(4):310-320. Epub 2018 Nov 27.

Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Backgrounds/aims: Compared with a single urinary biomarker, a composite of multiple urinary biomarkers may be more helpful for differentiating tubulointerstitial inflammation from interstitial fibrosis/tubular atrophy (IFTA) in kidney allografts.

Methods: In this cross-sectional cohort study, we collected urine samples from 115 patients with for-cause biopsy, 53 patients with stable allografts, and 50 living kidney donors. We measured the urinary levels of transglutaminase 2 (TG2), syndecan-4 (SDC4), alpha 1 microglobulin (A1M), interferon-inducible protein 10 (IP-10), interleukin 6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Read More

Adv Exp Med Biol 2018;1085:197-198

Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

Patients present with X-linked inheritance; Alport syndrome occurs in approximately 1 in 50,000 newborns. The systemic features include progressive interstitial nephritis, renal failure by the fifth decade, and neurosensory deafness. Read More

J Urol 2019 01;201(1)