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J Korean Med Sci 2020 Jul 6;35(26):e206. Epub 2020 Jul 6.

Division of Nephrology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.

Background: Although emerging evidence suggest acute kidney injury (AKI) progress to chronic kidney disease (CKD), long-term renal outcome of AKI still remains unclear. Acute tubular necrosis (ATN) is the most common cause of AKI due to ischemia, toxin or sepsis. Acute interstitial nephritis (AIN), caused by drugs or autoimmune diseases is also increasingly recognized as an important cause of AKI. Read More

J Intern Med 2020 Jul 2. Epub 2020 Jul 2.

Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.

Background: Hypertensive nephrosclerosis is the presumed underlying cause in many end stage kidney disease (ESKD) patients, but the diagnosis is disputed and based on clinical criteria with low diagnostic accuracy.

Objective: To evaluate and improve the diagnostic process for nephrosclerosis patients.

Methods: We included adults from the population-based HUNT study (n=50,552), Norwegian CKD patients referred for kidney biopsy 1988-2012 (n=7,261), and unselected nephrology clinic patients (n=193) used for matching. Read More

Int J STD AIDS 2020 Jul 1:956462420926881. Epub 2020 Jul 1.

Department of Internal Medicine, Division of Infectious Disease, University of New Mexico Hospital Health Science Center, Albuquerque, NM, USA.

Disseminated is a rare opportunistic infection reported most commonly in advanced human immunodeficiency virus (HIV) infection. Treatment can be further complicated by the occurrence of severe immune reconstitution inflammatory syndrome (IRIS). We present the first case of disseminated multi-drug-resistant in the setting of advanced HIV, complicated by IRIS in the form of granulomatous interstitial nephritis causing acute renal failure. Read More

J Immunother Cancer 2020 Jun;8(1)

Department of Medicine, Division of Nephrology, University Health Network, Toronto, Ontario, Canada

Background: Immune checkpoint inhibitors (ICPi) are a novel and promising anti-cancer therapy. There are limited data on the incidence, risk factors and outcomes of acute kidney injury (AKI) in patients receiving ICPi.

Methods: We conducted a cohort study of patients receiving ICPi at our center between 2010 and 2017 via electronic health record. Read More

J Allergy Clin Immunol Pract 2020 Jun 26. Epub 2020 Jun 26.

Renal Division, Department of Internal Medicine, Massachusetts General Hospital, Boston, MA.

Anti-programmed death-1/ligand-1 (PD-1/PD-L1) directed therapies are transforming cancer care, with durable anti-tumor responses observed in multiple cancer types. Toxicities arising from therapy are autoimmune in nature and may affect essentially any organ system. The immunologic basis of such toxities is complex, with contributions from T cell activation and autoantibody generation. Read More

Ter Arkh 2020 Jun 5;92(5):55-60. Epub 2020 Jun 5.

Sechenov First Moscow State Medical University (Sechenov University).

Recent studies have shown a high risk of chronic kidney disease and associated cardiovascular complications in patients with rheumatoid arthritis (RA), which determines the prognosis. However, the prevalence of chronic kidney disease (CKD) in RA has not been established in the Russians.

Aim: Study was to examine the prevalence, risk factors and histological variants of CKD in RA. Read More

Transplant Proc 2020 Jun 22. Epub 2020 Jun 22.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Many studies have been made on ABO-compatible kidney transplants following hematopoietic stem cell transplantation. However, there have been few reports on ABO-incompatible kidney transplantation following hematopoietic stem cell transplantation (HSCT). We report on the case of a successful ABO-incompatible kidney transplantation with high titers after bone marrow transplantation experienced no infectious episodes. Read More

Ann Pharmacother 2020 Jun 25:1060028020936778. Epub 2020 Jun 25.

Int Cancer Conf J 2020 Jul 22;9(3):127-132. Epub 2020 May 22.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582 Japan.

Nivolumab, an anti-programmed cell death-1 (PD-1) antibody, has attracted increasing attention as a new treatment modality for gastric cancer. Herein, a case of acute kidney injury in a 66-year-old man with gastric cancer treated with nivolumab is presented. Kidney biopsy revealed severe acute interstitial nephritis and mild immunoglobulin A nephropathy. Read More

J Exp Pharmacol 2020 4;12:129-136. Epub 2020 Jun 4.

Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The last-line agent for gram-negative bacteria that have developed resistance towards commonly used antibiotics is polymyxin E (PolyE). The renal toxicity attributed to this agent limits its use, proper dosing, and eventually its clinical efficacy. Although the exact mechanism of PolyE-induced nephrotoxicity is not obvious, some investigations suggest the role of oxidative stress and its associated events in this complication. Read More

Inflamm Bowel Dis 2020 Jun 22. Epub 2020 Jun 22.

Department of Infection and Immunology, Aichi Children's Health and Medical Center, Aichi, Japan.

Stem Cell Res 2020 07 12;46:101876. Epub 2020 Jun 12.

Convergent Research Consortium for Immunologic Disease; Transplant Research Center; Division of Nephrology, Department of Internal Medicine. Electronic address:

The human-induced pluripotent stem cell (KIN-hiPSCs) line (CMCi001-A), derived from peripheral blood mononuclear cells (PBMCs) of a 42-year-old woman with karyomegalic interstitial nephritis (KIN) caused by the mutation of FANCD2/FANCI-Associated Nuclease 1 (FAN1) gene, was generated using Sendai virus. KIN-hiPSCs showed a typical human embryonic stem cell like morphology and expressed all pluripotency-associated markers, and directly differentiated into all three germ layers. Karyotyping of PBMCs of the patient and KIN-hiPSCs showed 47, XXX. Read More

Pathogens 2020 Jun 16;9(6). Epub 2020 Jun 16.

Behavioral Science Foundation, Basseterre KN 0101, Saint Kitts and Nevis.

This study was performed to investigate the potential asymptomatic reservoir status among African green monkeys (AGMs) in the Caribbean island of Saint Kitts, and whether there is any renal pathology associated with exposure. Forty-eight percent of AGMs tested were positive for antibodies by the microscopic agglutination test. DNA was detected in 4% of kidney samples tested using a 32 gene based PCR. Read More

Int J Med Mushrooms 2020 ;22(4):313-323

Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, 130118, P.R. China.

Previous study found that the fruit body of Irpex lacteus has an effect on the prevention and treatment of chronic nephritis. In this study, we systematically investigated the preventive effect of small molecular fraction (SMF) of the fungal fruit body against chronic nephritis. In addition, we analyzed, isolated, and identified the chemical constituents of SMF, and screened the activity of three small peptides isolated in vitro. Read More

Zhonghua Gan Zang Bing Za Zhi 2020 May;28(5):381-385

Department of Infectious Diseases, the First Hospital of Peking University, Beijing 100034, China.

Renal dysfunction is common in patients with decompensated cirrhosis. The types include of prerenal and postrenal, structural kidney disease, interstitial nephritis and functional renal failure, which is related to hemodynamic changes without obvious histopathological changes, the most common of which are acute kidney injury and hepatorenal syndrome. In recent years, there have been updated to some extents in the liver cirrhosis combined with kidney diseases, especially in the definition, classification, pathogenesis, diagnostic criteria, management process of acute kidney injury and hepatorenal syndrome. Read More

J Nephrol 2020 Jun 11. Epub 2020 Jun 11.

Division of Nephrology, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico Milano, Milano, Italy.

The kidney is frequently involved by autoimmune rheumatic diseases. The renal manifestations may be variable, ranging from asymptomatic proteinuria and microscopic haematuria to nephrotic syndrome and rapidly progressive glomerulonephritis or vasculitis. In a number of cases the kidney involvement is related to the treatment of the original disease and may represent a major cause of morbidity and mortality. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620932450

Bassett Medical Center, Cooperstown, NY, USA.

Acute interstitial nephritis is a well-known cause of acute kidney injury, but its association with cocaine use is extremely rare. In this article, we chronicle the case of a patient who developed acute interstitial nephritis secondary to cocaine insufflation. Furthermore, we conducted a systematic literature search of MEDLINE, Cochrane, Embase, and Scopus databases regarding cocaine-induced acute interstitial nephritis. Read More

Trop Doct 2020 Jun 6:49475520929505. Epub 2020 Jun 6.

Department of Infectious Diseases and Clinical Microbiology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Brucellosis is the most common zoonosis in the world. It can affect several organs or systems, of which the genitourinary is the second most common after the musculoskeletal. Renal involvement in brucellosis takes the form of IgA nephropathy, interstitial nephritis, pyelonephritis, mixed cryoglobulinemia and kidney failure. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620933438

Geisinger Commonwealth School of Medicine, Scranton, PA, USA.

In this article, we present a case of a young female patient with previously diagnosed lupus pneumonitis, now with a flare and new superimposed COVID-19 infection that was treated with intravenous steroids. On computed tomography scans, she had extensive interstitial lung fibrosis in addition to a positive COVID-19 polymerase chain reaction test requiring 6 L of oxygen via nasal cannula on admission. After administration of methylprednisolone, the patient improved and was weaned off her oxygen requirements and was discharged home. Read More

Ann Afr Med 2020 Apr-Jun;19(2):147-149

Department of Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Sjogren syndrome (SS) is a systemic autoimmune disorder with predominant exocrine gland involvement leading to sicca symptoms. Among extraglandular manifestations, renal disease is the most common. Tubular interstitial nephritis and renal tubular acidosis (RTA) are the common presentations. Read More

IDCases 2020 22;21:e00819. Epub 2020 May 22.

Advocate Illinois Medical Center, Internal Medicine Department, 836 W Wellington Ave, Chicago, IL 60657, United States.

Influenza is an annual epidemic disease that in severe cases can lead to the development of ARDS. Current practice recommends the routine use of neuraminidase inhibitors with emerging evidence for the use of endonuclease inhibitors. We present the case of a 22-year-old female with diabetes and IgG4 tubulo-interstitial nephritis that developed rapidly progressive ARDS from influenza infection requiring ventilatory support and extra corporeal oxygenation in which oseltamivir and baloxavir were used in combination. Read More

BMC Nephrol 2020 Jun 1;21(1):208. Epub 2020 Jun 1.

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan.

Background: The aim of the present study was to evaluate the association between the histology of active and chronic lesions and urinary protein and serum creatinine (SCr) levels, as common clinical endpoints in clinical trials for lupus nephritis (LN).

Methods: In total, 119 patients diagnosed with LN class III, IV, and V, as defined by the International Society of Nephrology/Renal Pathology Society, between 1990 and 2015, were enrolled in the present study. Multiple regression analysis was performed to explore semi-quantitative histological variables associated with urinary protein and SCr levels. Read More

Medicine (Baltimore) 2020 May;99(21):e20464

Department of Nephrology, Rheumatology, Endocrinology and Metabolism.

Introduction: Immune checkpoint inhibitors including nivolumab, an antibody against programmed death-1, have been increasingly introduced in various cancer treatment regimens, and are reported to be associated with immune-related adverse events. Nivolumab-induced renal injury is generally caused by acute interstitial nephritis and is managed by drug discontinuation and steroid therapy. Although this agent can infrequently induce glomerulonephritis, the pathogenesis and therapeutic strategy remain undetermined. Read More

Praxis (Bern 1994) 2020 Jul 29;109(9):731-735. Epub 2020 May 29.

Ultrasound Learning Center (ULC) der European Federation of Ultrasound in Medicine and Biology (EFSUMB) am Institut für Allgemeine Innere Medizin und Nephrologie, Klinik Hirslanden, Zürich.

Renal Monomorphology in COVID-19 with Acute Renal Insufficiency A 78-year-old ventilator-dependent COVID-19 patient developed severe renal failure with an estimated glomerular filtration rate of 20 ml/min per 1.73 m2 and nephrotic proteinuria. Sonography showed echo-dense and enlarged kidneys with high resistance indices (>0. Read More

Ocul Immunol Inflamm 2020 May 28:1-6. Epub 2020 May 28.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine , Chicago, Illinois, USA.

Purpose: To describe clinical manifestations of patients with tubulointerstitial nephritis and uveitis syndrome (TINU) with a focus on posterior segment findings.

Methods: Retrospective chart review.

Results: 17 patients were diagnosed with TINU. Read More

Am J Case Rep 2020 May 27;21:e921445. Epub 2020 May 27.

Department of Nephrology, Virgin Health Hospital, Toledo, Spain.

BACKGROUND Visceral leishmaniasis (VL) is an endemic systemic disease in the Mediterranean countries, including Spain. This vector-borne infection can present with several clinical presentations, from asymptomatic to severe forms. Renal impairment is frequently described in VL but is usually mild and related to interstitial nephritis, being that glomerular involvement is rarely found. Read More

Pediatr Rheumatol Online J 2020 May 24;18(1):39. Epub 2020 May 24.

Department of Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, People's Republic of China.

Background: Sjögren syndrome (SS) is a rare disease in pediatrics, and little attention has been paid to the clinical feature in these patients. To date, there are few cases concern about neurological and nephrological disorders in childhood Sjögren syndrome. We describe a case of Sjögren syndrome in a 12-year-old girl who developed neurological disorders and interstitial nephritis and review the literature currently available on this topic. Read More

Lancet 2020 05;395(10237):1659-1668

Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.

Urinary tract infections (UTIs) in children are among the most common bacterial infections in childhood. They are equally common in boys and girls during the first year of life and become more common in girls after the first year of life. Dividing UTIs into three categories; febrile upper UTI (acute pyelonephritis), lower UTI (cystitis), and asymptomatic bacteriuria, is useful for numerous reasons, mainly because it helps to understand the pathophysiology of the infection. Read More

Emerg Radiol 2020 May 22. Epub 2020 May 22.

Dipartimento di Biomedicina, Neuroscienze e Diagnostica avanzata (BIND), University Hospital "Paolo Giaccone", Via del Vespro, 129, 90127, Palermo, Italy.

Contrast-enhanced CT is not routinely indicated in uncomplicated urinary infections, but it may be necessary in patients with specific risk factors (i.e., diabetes, immunocompromised patients, history of stones, or prior renal surgery) or in patients not responding to antibiotics and in detecting complications of pyelonephritis. Read More

Medicina (B Aires) 2020 ;80(3):229-240

Sociedad Argentina de Infectología, Argentina.

The Argentine Society of Infectious Diseases and other scientific societies have updated these recommendations based on data on urinary tract infections in adults obtained from a prospective multicenter study conducted in Argentina during 2016-2017. Asymptomatic bacteriuria should be treated only in pregnant women, who should also be systematically investigated; the antibiotics of choice are nitrofurantoin, amoxicillin, clavulanic/amoxicillin, cephalexin and trimethoprim-sulfamethoxazole. In procedures involving injury to the urinary tract with bleeding, it is recommended to request urine culture and, in the presence of bacteriuria, antimicrobial treatment according to sensitivity should be prescribed from immediately before up to 24 hours after the intervention. Read More

Pathol Int 2020 May 17. Epub 2020 May 17.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

A 70-year-old Japanese man with diabetes mellitus was referred to our hospital for treatment of renal dysfunction. Renal biopsy revealed that the tubular basement membrane (TBM) showed extreme thickening histologically, and selective polyclonal immunoglobulin G deposition on the thickened TBM, whereas no immunoglobulin deposition was found in the glomeruli in an immunofluorescence study. In electron microscopy, a powdery type of electron dense material, which was similar to that seen in Randall-type monoclonal immunoglobulin deposition disease (MIDD), was observed on the tubular epithelial side of the TBM. Read More

Semin Arthritis Rheum 2020 May 15. Epub 2020 May 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No 1, Shuaifuyan, Wangfujing St, Beijing 100730, China. Electronic address:

Background: Renal Fanconi syndrome (FS) is rare in primary Sjӧgren's syndrome (pSS). We aimed to describe the clinicopathological characteristics of pSS associated FS (pSS-FS) and its responses to treatment.

Methods: We reported 25 cases of pSS-FS patients and retrospectively reviewed their clinical records, kidney pathology and follow-up data. Read More

Comb Chem High Throughput Screen 2020 May 17. Epub 2020 May 17.

Department of Rheumatology, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005. China.

Objective: Vasculitis is the basic pathological change of systemic lupus erythematosus(SLE). Radix Paeoniae Rubra (RPR), a traditional Chinese herb with the function of reducing blood stasis, has antiinflammatory and immunoregulatory properties. This study explored the effects of RPR on the kidneys of lupus-like symptoms of mrl (MRL/lpr) mice from the perspective of intercellular cell adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1(VCAM-1) and platelet endothelial cell adhesion molecule-1(PECAM-1). Read More

Pediatr Res 2020 May 14. Epub 2020 May 14.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Background: To evaluate the apoptosis inhibitor of macrophage (AIM) deposition patterns on the kidneys of children with IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) and to investigate the clinical usefulness of serum and/or urinary AIM levels as biomarkers for the disease activity.

Methods: Immunohistochemical study was performed in the kidneys of 37 patients with IgAN and 10 patients with HSPN. Serum and urinary AIM levels in the patients and 20 healthy controls (HCs) were quantified by enzyme-linked immunosorbent assay. Read More

Cureus 2020 Apr 7;12(4):e7583. Epub 2020 Apr 7.

Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, Albuquerque, USA.

Infectious mononucleosis, a syndrome characterized by the triad of pharyngitis, fever, and lymphadenopathy, is caused in the majority of cases by Epstein-Barr virus and usually presents in adolescents and young adults. The disease is for the most part self-limited with full recovery; however, life-threatening complications can occur. Manifestations of Epstein-Barr virus associated infectious mononucleosis can be variable and at times atypical, leading to a delay in diagnosis and consequently unnecessary tests and treatment. Read More

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):549-552

Advanced Research Center (Genetics), Narayana Medical College, Nellore, Andhra Pradesh, India.

Sarcoidosis is a systemic disease characterized by non caseating granulomatous inflammation. Sarcoidosis can affect any organ, but it most commonly involves the lungs and lymph nodes. The exact incidence of renal involvement in sarcoidosis remains unclear, but it is found to be rare. Read More

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):335-341

Department of Nephrology, The Kidney Centre Post Graduate Training Institute, Karachi, Pakistan.

Tubulo-interstitial nephritis (TIN) is an important cause of acute renal failure which may progresses to chronic kidney disease (CKD). TIN is often under diagnosed with there are no specific signs and symptoms. As this entity has paramount importance, so we evaluated the frequency and etiological of TIN both acute TIN (ATIN) and chronic tububulo-interstitial nephritis (CTIN) in renal biopsies. Read More

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):312-319

Department of Internal Medicine 2, SRH Wald-Klinikum Gera, Gera, Germany.

Proton-pump inhibitors (PPIs) are the most effective therapy for gastric acid- related diseases. They are generally well tolerated with rare, often self-limiting adverse reactions. On the other hand, there is growing concern regarding the increased public access and inappropriate PPI use. Read More

Forensic Sci Med Pathol 2020 May 11. Epub 2020 May 11.

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00161, Rome, Italy.

Meningoencephalitis is the most common neurological complication related to Epstein-Barr virus (EBV), and in immunocompetent adults, it is most commonly self-limited. We describe a case of fatal EBV infection characterized by meningoencephalitis, foci of myocarditis and interstitial nephritis in an immunocompetent 74-year-old man. The postmortem diagnosis was made based on the presence of EBV DNA in the cerebrospinal fluid and by immunohistochemical assay that showed spots of intracellular positivity to anti-EBV antibody in brain tissue. Read More

Am J Med Sci 2020 Apr 17. Epub 2020 Apr 17.

Department of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.

Immunoglobulin A (IgA) nephropathy is one of the most common glomerulonephritis characterized by the deposition of IgA in glomerular mesangium. Karyomegalic interstitial nephritis (KIN) is a rare interstitial nephritis with potential hereditary factors. IgA nephropathy concomitant with KIN has not yet been reported. Read More

Am J Kidney Dis 2020 Jul 5;76(1):144-147. Epub 2020 May 5.

University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address:

We report a case of a patient who developed dialysis-requiring acute kidney injury (AKI) after the use of canagliflozin. A 66-year-old man with type 2 diabetes who was recovering from left knee septic arthritis at a rehabilitation facility was admitted with oliguric AKI 5 days after starting treatment with canagliflozin, an inhibitor of sodium/glucose cotransporter 2 (SGLT2). The patient presented with hematuria, non-nephrotic-range proteinuria, and serum creatinine level of 6. Read More

Medicine (Baltimore) 2020 May;99(19):e19960

Department of Orthopedic, Chi Mei Medical Center, Tainan, Taiwan.

Objectives: This meta-analysis assessed the efficacy and safety of novel β-lactam/β-lactamase inhibitor combinations in the treatment of complicated urinary tract infection (cUTI)/acute pyelonephritis (APN).

Methods: PubMed, Web of Science, EBSCO (Elton B. Stephens Co. Read More

Adv Gerontol 2020 ;33(1):113-120

Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky pr., Syktyvkar 557001, Komi Republic, Russian Federation, e-mail:

The purpose of the work is to study the characteristics of the course of chronic kidney disease in elderly patients based on the analysis of the register of chronic kidney disease (CKD) for 2015-2018. in the Department of Nephrology, the Komi Republican Clinical Hospital. There are 484 patients in the register, of whom 231 are men (47,7%), 253 women (52,3%). Read More

World J Clin Oncol 2020 Apr;11(4):190-204

Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029094, Bahia, Brazil.

Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits the efficacy of cancer treatment. The kidney is an important elimination pathway for many antineoplastic drugs and their metabolites, which occurs by glomerular filtration and tubular secretion. Chemotherapeutic agents, both conventional cytotoxic agents and molecularly targeted agents, can affect any segment of the nephron including its microvasculature, leading to many clinical manifestations such as proteinuria, hypertension, electrolyte disturbances, glomerulopathy, acute and chronic interstitial nephritis, acute kidney injury and at times chronic kidney disease. Read More

Rheumatology (Oxford) 2020 Apr 30. Epub 2020 Apr 30.

Rheumatology Department, Cliniques Universitaires Saint-Luc and Pôle de Pathologies Rhumatismales Inflammatoires et Systémiques, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain.

Objectives: In patients with LN, clinical and histological responses to treatment have been shown to be discordant. We investigated whether per-protocol repeat kidney biopsies are predictive of LN relapses and long-term renal function impairment.

Methods: Forty-two patients with incident biopsy-proven active proliferative (class III/IV±V) LN from the database of the UCLouvain were included in this retrospective study. Read More

J Bras Nefrol 2020 Apr 27. Epub 2020 Apr 27.

Dr.RMLIMS, Department of Pathology, Vibhuti Khand, Gomti Nagar, Lucknow, 226010, India.

Imatinib, which inhibits tyrosine kinase activity of Bcr-Abl protein, is a standard form of treatment for chronic myeloid leukemia (CML). Through its immunomodulatory effect it affects T cell function in a number of ways. It inhibits antigen-induced T cell activation and proliferation. Read More

Front Immunol 2020 15;11:671. Epub 2020 Apr 15.

Department of Biomedical Engineering, University of Houston, Houston, TX, United States.

CD163 is a marker for alternatively activated macrophages, which have been implicated in the pathogenesis of lupus nephritis (LN). In our preliminary screening of urine proteins in LN, urine soluble CD163 (sCD163) was significantly elevated in patients with active LN. To evaluate the potential of sCD163 as a biomarker in LN, urine sCD163 was assayed in patients with active LN, active non-renal lupus patients (ANR), inactive SLE and healthy controls (HC), using ELISA and normalized to urine creatinine. Read More

Am J Nephrol 2020 22;51(6):483-492. Epub 2020 Apr 22.

Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, China.

Background: A revision of the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification for lupus nephritis has been published in 2018. The current study aimed to verify the utility of this system.

Materials And Methods: A total of 101 lupus nephritis patients from a large Chinese cohort who underwent renal biopsy in Peking University First Hospital were reevaluated by 2 renal pathologists, who had no knowledge of the clinical findings. Read More

Adv Exp Med Biol 2020 ;1244:287-293

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

With the increasing use of immunotherapy, there has been an associated increased survival in many cancers but has also resulted in unregulated organ-specific toxicities. In this chapter, we discuss the renal toxicities associated with a checkpoint inhibitor (CPI) from the typical acute tubulointersitial nephritis to glomerulonephritis, their proposed mechanisms, and treatments. We also discuss the use of CPI and reactivation of preexisting auto-immune diseases and focus on renal cell cancer in setting of Chronic kidney disease (CKD). Read More

Histopathology 2020 Apr 16. Epub 2020 Apr 16.

The University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

Aims: Immune checkpoint inhibitors (ICIs) have revolutionised the treatment of advanced malignancies by boosting immune-mediated destruction of neoplastic cells, but are associated with side effects stemming from generalised immune system activation against normal tissues. Checkpoint ligand expression in non-tumoral cells of tissues affected by immune-related adverse effects has been described in ICI-associated hypophysitis, myocarditis, and acute interstitial nephritis. We aimed to investigate the tissue expression of the immune checkpoint receptor programmed cell death-1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), in PD-1 inhibitor-associated colitis (PD1i colitis). Read More