7,774 results match your criteria Nephrectomy Radical


Only three cycles of nivolumab showed remarkable durable response and reversible myeloradiculoneuropathy in a patient with metastatic papillary renal cell carcinoma type 2.

IJU Case Rep 2021 May 17;4(3):139-142. Epub 2021 Feb 17.

Department of Urology Oita University Faculty of Medicine Yufu Oita Japan.

Introduction: The efficacy of nivolumab for non-clear cell renal cell carcinoma is still unclear. We present a rare case of metastatic papillary renal cell carcinoma remarkably responded to nivolumab but developed myeloradiculoneuropathy as immune-related adverse event.

Case Presentation: The patient had previously undergone radical nephrectomy for right renal mass and was diagnosed as papillary renal cell carcinoma type 2, pT3bN0M0. Read More

View Article and Full-Text PDF

Relationship between miR-155 expression and clear cell papillary renal cell carcinoma in the dialyzed kidney.

IJU Case Rep 2021 May 15;4(3):127-131. Epub 2021 Mar 15.

Department of Urology School of Medicine Iwate Medical University Yahaba Japan.

Introduction: Clear cell papillary renal cell carcinoma often develops in the context of the dialyzed kidney (end-stage renal disease). However, the relationship between clear cell papillary renal cell carcinoma and microRNA expression in patients with end-stage renal disease remains unclear.

Case Presentation: A left renal tumor measuring 22 mm was detected and a radical nephrectomy was performed on a 50-year-old man who had received hemodialysis for the past 6 years. Read More

View Article and Full-Text PDF

Angiomyolipoma rupture: does size always matter?

Cent European J Urol 2021 25;74(1):48-50. Epub 2021 Feb 25.

University of Zielona Góra, Collegium Medicum, Department of Urology, Zielona Góra, Poland.

Angiomyolipoma (AML) is the most common benign renal neoplasm. Although asymptomatic lesions rarely lead to clinical dilemma, the management of ruptured tumours can become challenging. The size of the tumour has been widely accepted as a prognostic factor for intervention but there exists some evidence against considering the size as the only prognostic factor for intervention in AML. Read More

View Article and Full-Text PDF
February 2021

Laparoendoscopic single-site simultaneous bilateral nephrectomy: first reported case series.

Cent European J Urol 2021 15;74(1):44-47. Epub 2021 Jan 15.

Clinic Institute of Nephrology and Urology (ICNU), Universidad de Barcelona, Barcelona, Spain.

Bilateral renal tumors in patients on dialysis are usually managed with bilateral nephrectomy. With traditional laparoscopy, this procedure requires the insertion of multiple trocars. Laparoendoscopic single-site surgery (LESS) uses a single umbilical incision to insert multiple instruments and is also employed for extraction of specimens. Read More

View Article and Full-Text PDF
January 2021

Evaluation of comorbidity indices in determining the most suitable candidates for uro-oncological surgeries in elderly men.

Cent European J Urol 2021 5;74(1):24-38. Epub 2021 Mar 5.

Health Science University, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Department of Urology, Ankara, Turkey.

Introduction: We aimed to evaluate the superiority of different comorbidity indices in determining the most suitable elderly male candidates for uro-oncological operations. While making this assessment, we also aimed to determine the risk factors that may affect surgery-related major complications and overall survival.

Material And Methods: Data of 543 male patients, 60 years or older, who underwent uro-oncological surgery (radical cystectomy, radical prostatectomy, radical or partial nephrectomy, transurethral resection of bladder tumor) between September 2009 and January 2019 were retrospectively evaluated. Read More

View Article and Full-Text PDF

Primary malignant teratoma of the kidney: a rare case report and literature review.

Transl Androl Urol 2021 Apr;10(4):1807-1812

Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Teratomas originate from pluripotent cells and can differentiate along one or more embryonic germ lines. Renal teratoma is infrequent and malignant renal teratoma is even rarer. Experience in the diagnosis and treatment of this uncommon malignancy is seriously limited. Read More

View Article and Full-Text PDF

Xanthogranulomatous pyelonephritis in an eight year old male child: A case report and review of the literature.

Int J Surg Case Rep 2021 Apr 30;82:105943. Epub 2021 Apr 30.

Faculty of Medicine, Kilimanjaro Christian Medical University College, Box 2240, Moshi, Tanzania; Department of Urology, Kilimanjaro Christian Medical Centre, Box 3010, Moshi, Tanzania.

Introduction And Importance: Xanthogranulomatous pyelonephritis is an extremely rare but known form of chronic pyelonephritis resulting from prolonged suppuration of the kidney. Pre-operatively, it may mimic renal tuberculosis or neoplastic lesions including renal cell carcinoma due to its vague clinical presentation, equivocal laboratory and radiological investigations. Due to its rarity and academic interest, herein we report such a rare case we recently encountered in our clinical practice. Read More

View Article and Full-Text PDF

Validation of a German translation of the CARE questionnaire and its implementation as electronic PROM to assess patient-reported postoperative convalescence and recovery after major urological surgery.

World J Urol 2021 May 8. Epub 2021 May 8.

Department of Urology and Urological Surgery, Medical Faculty, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: To validate a German translation of the convalescence and recovery evaluation (CARE) as an electronic patient-reported outcome measure (ePROM) and use it to assess recovery after major urological surgery.

Methods: The CARE questionnaire was provided to patients scheduled for major urological surgery preoperatively, at discharge and 6 weeks postoperatively, using an ePROM system. Cronbach's alpha, inter-scale correlations and confirmatory factor analysis (CFA) were used to validate the translation. Read More

View Article and Full-Text PDF

Unplanned open conversion during radical or partial nephrectomy: Comparing outcomes and trends.

Urology 2021 May 4. Epub 2021 May 4.

Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO. Electronic address:

Objectives: To compare perioperative outcomes between open conversion and planned open surgical approach and to investigate trends.

Materials And Methods: The National Cancer Database (NCDB) was queried for cT1 and cT2 RCC treated by radical (RN) or partial (PN) nephrectomy between 2010 and 2016. We retrospectively analyzed patient demographics, clinical tumor characteristics, and perioperative outcomes between unplanned open conversion and planned open approaches for RN and PN. Read More

View Article and Full-Text PDF

Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a Single Institutional Experience with Clinicopathological and Molecular Characteristics.

Hum Pathol 2021 May 4. Epub 2021 May 4.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905. Electronic address:

Aims: Low-grade oncocytic tumor of the kidney (LOT) is characterized by cytoplasmic eosinophilia and a CK7-positive/CD117-negative immunophenotype. Morphologically, they exhibit overlapping features with oncocytoma and chromophobe renal cell carcinoma (chRCC). Our aim was to obtain long-term clinical follow-up data, clinicopathological and molecular characteristics, and incidence of LOT. Read More

View Article and Full-Text PDF

Utility of preoperative vascular embolization of renal tumors with left renal vein tumor thrombus.

Actas Urol Esp 2021 May 3. Epub 2021 May 3.

Unidad de Tumores Renales con Afectación Venosa (TRAV), Servicio de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.

Introduction And Objectives: Preoperative renal artery embolization (PRAE) for large renal masses may be performed prior to nephrectomy in order to simplify the procedure and reduce intraoperative bleeding. The objective of this work is to determine the role of PRAE on intraoperative bleeding and postoperative complications in left renal tumors with tumor thrombus limited to the left renal vein (level 0).

Material And Methods: Retrospective analysis to evaluate 46 patients who underwent left radical nephrectomy and thrombectomy for the treatment of renal cell carcinoma with level 0 tumor thrombus during the period 1990-2020. Read More

View Article and Full-Text PDF

CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma.

Cancers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

Department of Urology, University Hospital Bonn, 53127 Bonn, Germany.

Background: Circular RNA (circRNA) plays an important role in the carcinogenesis of various tumors. It is assumed that circRNAs have a high tissue and tumor specificity, thus they are discussed as cancer biomarkers. The knowledge about circRNAs in clear cell renal carcinoma (ccRCC) is limited so far, and thus we studied the expression profile of seven circRNAs (circCOL5A1, circEHD2, circEDEM2, circEGNL3, circNETO2, circSCARB1, circSOD2) in a cohort of ccRCC patients. Read More

View Article and Full-Text PDF

Can we Avoid the Unnecessary Loss of nephrons in the Management of Small Solid Renal Masses? Additional Clinical Parameters to Predict Benign-malign Distinction.

Sisli Etfal Hastan Tip Bul 2021 17;55(1):53-61. Epub 2021 Mar 17.

Department of Urology, University of Health Science Turkey, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Turkey.

Objectives: We aimed to investigate the predictive value of additional parameters for distinguishing benign-malign tumors and to prevent the loss of nephrons in small (≤4 cm) solid renal masses.

Methods: The data of 56 patients underwent partial or radical nephrectomy between September 2009 and December 2017 due to diagnosis of localized renal cell carcinoma were retrospectively analyzed. Demographic datas, histopathological tumor types, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), mean platelet volume (MPV), the Framingham risk score and its components, postoperative follow-up results were recorded. Read More

View Article and Full-Text PDF

Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.

Cancer Treat Res Commun 2021 18;27:100374. Epub 2021 Apr 18.

Department of Urology. Hospital Clínico Universitario de Valencia, Av. Blasco Ibáñez, 17, 46010. Valencia- España. Electronic address:

Introduction: Renal cell carcinoma (RCC) accounts for 2-3% of all tumors being the most frequent solid lesion in the kidney.

Objective: To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness.

Patients And Methods: Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. Read More

View Article and Full-Text PDF

A Nationwide Survey on the Impact of COVID-19 Pandemic on Minimal Invasive Surgery in Urology Practice.

Int J Clin Pract 2021 May 1:e14309. Epub 2021 May 1.

Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Urology, Istanbul, Turkey.

Objective: The beta-coronavirus (COVID-19) pandemic has changed the clinical approach of 93% of urologists worldwide, and this situation has affected the use of laparoscopic and robot-assisted laparoscopic methods, which are known as minimally invasive surgery (MIS). This study aimed to determine the effects of the COVID-19 pandemic on MIS in urology practice at national level.

Design, Setting And Participants: A total of 234 urologists in Turkey participated in an online survey between August 22 and September 23, 2020. Read More

View Article and Full-Text PDF

Superselective Ischemia in Robotic Partial Nephrectomy Does Not Provide Better Long-term Renal Function than Renal Artery Clamping in a Randomized Controlled Trial (EMERALD): Should We Take the Risk?

Eur Urol Focus 2021 Apr 27. Epub 2021 Apr 27.

Urology Department, Grenoble University Hospital, Grenoble, France.

Background: Superselective clamping of tumor-targeted arteries aims to eliminate ischemia of the remnant kidney while keeping tumor bed bloodless during excision.

Objective: To evaluate the impact of superselective clamping on long-term renal function, compared with renal artery early unclamping.

Design, Setting, And Participants: A randomized monocentric single-blind trial (1:1) was conducted from February 2018 to August 2019. Read More

View Article and Full-Text PDF

Prognostic Factors and Current Treatment Strategies for Renal Cell Carcinoma Metastatic to the Brain: An Overview.

Cancers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Department of Biomedical Sciences and Human Oncology, University of Bari, 70122 Bari, Italy.

Renal cell carcinoma (RCC) is one of primary cancers that frequently metastasize to the brain. Brain metastasis derived from RCC has the propensity of intratumoral hemorrhage and relatively massive surrounding edema. Moreover, it confers a grim prognosis in a great percentage of cases with a median overall survical (mOS) around 10 months. Read More

View Article and Full-Text PDF

Role of the Laparoscopic Approach for Complex Urologic Surgery in the Era of Robotics.

J Clin Med 2021 Apr 21;10(9). Epub 2021 Apr 21.

Department of Urology, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

(1) Introduction: The advent of robotic surgery led to the assumption that laparoscopic surgery would be replaced entirely. However, the high costs of robotic surgery limit its availability. The aim of the current study was to assess the feasibility of the 3D laparoscopic approach for the most complex urological procedures. Read More

View Article and Full-Text PDF

Renal Cell Carcinoma with or without Tumor Thrombus Invading the Liver, Pancreas and Duodenum.

Cancers (Basel) 2021 Apr 3;13(7). Epub 2021 Apr 3.

Department of Surgery, Miami Transplant Institute, University of Miami Miller school of Medicine, Miami, FL 33136, USA.

Background: The purpose of this study is to report the outcomes of a series of patients with locally advanced renal cell carcinoma (RCC) who underwent radical nephrectomy, tumor thrombectomy, and visceral resection.

Patients And Methods: 18 consecutive patients who underwent surgical treatment in the period 2003-2019 were included. Neoplastic extension was found extending into the pancreas, duodenum, and liver in 9(50%), 2(11. Read More

View Article and Full-Text PDF

Efficacy of Cabozantinib in Metastatic Papillary Renal Cell Carcinoma Following Ineffective Treatment With Initial Therapy of Nivolumab and Ipilimumab.

In Vivo 2021 May-Jun;35(3):1743-1747

Department of Urology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

Sunitinib is listed as first-line therapy for non clear-cell renal cell carcinoma (RCC) in several guidelines. However, in the era of immunotherapy, there is an urgent need for updated evidence for the treatment of metastatic non clear-cell RCC. Herein, we present three cases of patients with type 2 papillary RCC who were effectively treated with cabozantinib. Read More

View Article and Full-Text PDF
January 2021

Multidisciplinary surgical approach to renal cancer with vena cava invasion and pulmonary embolism.

Rozhl Chir 2021 ;100(2):88-93

Introduction: Renal cancer is unique for many reasons. One reason is that renal cell carcinoma can grow directly into the drainage veins of the kidney, which enter the inferior vena cava leading to the heart. This growth of tumor cells into the veins is called a tumor thrombus and is a locally aggressive renal cancer. Read More

View Article and Full-Text PDF

Upper urinary tract surgery and radical prostatectomy with Senhance robotic system: Single center experience-First 100 cases.

Int J Med Robot 2021 Apr 26. Epub 2021 Apr 26.

Department of Urology, University Hospital Center Zagreb, Zagreb, Croatia.

Background: The Senhance robotic surgery system is a novel robotic platform used in several European and World centres. We present our experience in urologic surgery using this platform.

Patients And Methods: From May 2019 to December 2020, we performed 30 operations of upper urinary tract (UUT) and 70 extraperitoneal radical robotic prostatectomies (RRP). Read More

View Article and Full-Text PDF

Is preoperative neutrophil-to-lymphocyte ratio a red flag which can predict high-risk pathological characteristics in renal cell carcinoma?

Urol Ann 2021 Jan-Mar;13(1):47-52. Epub 2021 Jan 19.

Department of Biochemistry, Kasturba Medical College Hospital, Mangalore, Karnataka, India.

Introduction: Renal cell carcinoma (RCC) is known to invoke both immunological and inflammatory responses. While the neutrophils mediate the tumor-induced inflammatory response, the lymphocytes bring about the various immunological events associated with it. The neutrophil-to-lymphocyte ratio (NLR) is a simple indicator of this dual response. Read More

View Article and Full-Text PDF
January 2021

Management of colon-invading renal cell carcinoma: Operative technique and systematic review.

Urol Ann 2021 Jan-Mar;13(1):1-8. Epub 2021 Jan 19.

Department of Urology, Beaumont Hospital, Dublin, Ireland.

Invasion into adjacent organs by non-metastatic renal cell carcinoma (RCC) occurs in 1% of patients suitable for resection. Colonic invasion is rare and presents technical challenges. No prospective data exists to guide management of these patients. Read More

View Article and Full-Text PDF
January 2021

Oncocytic Papillary Renal Cell Carcinoma in an 11-year-old girl.

Urology 2021 Apr 20. Epub 2021 Apr 20.

Department of Urology, University of Balamand, Saint George Hospital University Medical Center, Beirut 1100 2807, Lebanon. Electronic address:

Oncocytic Papillary Renal Cell Carcinoma (OPRCC) is a rare variant of renal cell carcinoma with overlapping characteristics type 1 and 2 of papillary renal carcinoma. Based on the literature, OPRCC is predominantly present in adult males. OPRCC has a specific genetic affiliation with the Fumarate Hydratase gene requiring all patients diagnosed with OPRCC to undergo genetic testing. Read More

View Article and Full-Text PDF

Application of the indocyanine green fluorescence imaging method in laparoscopic resection of a solitary retroperitoneal metastasis of renal cell carcinoma: A case report.

Asian J Endosc Surg 2021 Apr 23. Epub 2021 Apr 23.

Department of Urology, Shiga University of Medical Science, Ōtsu, Japan.

Fluorescence image-guided surgery has improved intraoperative identification of anatomic structures including visualization of vascular anatomy. Herein, indocyanine green (ICG) fluorescence imaging was applied to identify of a recurrent small tumor of renal cell carcinoma (RCC) during laparoscopic surgery. The patient underwent left laparoscopic radical nephrectomy via the retroperitoneal approach for RCC (clear cell carcinoma, pT1bN0M0) at the age of 39 years. Read More

View Article and Full-Text PDF

Late metastasis of renal cell carcinoma cloaked in a non-healing foot ulcer: A very rare presentation.

Urol Case Rep 2021 Sep 31;38:101670. Epub 2021 Mar 31.

Department of Urology, Centre Hospitalier Wallonie Picarde, Tournai, Belgium.

A 67-year-old male who underwent right radical nephrectomy 15 years prior to current diagnosis for pT2bN0M0 ccRCC presented with an isolated purulent ulcer on left foot. Data was collected from records, radiological scans and histological reviews. The non-healing ulcer did not respond to antibiotic therapy and surgical debridement. Read More

View Article and Full-Text PDF
September 2021

Comparison between minimally-invasive partial and radical nephrectomy for the treatment of clinical T2 renal masses: results of a 10-year study in a tertiary care center.

Minerva Urol Nephrol 2021 Apr 22. Epub 2021 Apr 22.

Division of Urology, Department of Oncology, School of Medicine, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy.

Background: Even if partial nephrectomy (PN) is nowadays considered the standard for managing cT1 renal masses, its role in the management of cT2 kidney tumors is controversial. We aimed to compare oncologic and functional outcomes of minimally invasive radical nephrectomy (RN) and PN in cT2 renal masses.

Methods: Patients with cT2 renal masses underwent minimally-invasive PN or RN performed by a highly experienced single surgeon from 2009 to 2019 were considered. Read More

View Article and Full-Text PDF

A three-feature prediction model for metastasis-free survival after surgery of localized clear cell renal cell carcinoma.

Sci Rep 2021 Apr 21;11(1):8650. Epub 2021 Apr 21.

Department of Oncology and Radiotherapy, Fican West Cancer Centre, University of Turku and Turku University Hospital, Hämeentie 11, Post Box 52, 20521, Turku, Finland.

After surgery of localized renal cell carcinoma, over 20% of the patients will develop distant metastases. Our aim was to develop an easy-to-use prognostic model for predicting metastasis-free survival after radical or partial nephrectomy of localized clear cell RCC. Model training was performed on 196 patients. Read More

View Article and Full-Text PDF

Human immunodeficiency virus-related renal cell carcinoma: a retrospective study of 19 cases.

Infect Agent Cancer 2021 Apr 21;16(1):26. Epub 2021 Apr 21.

Department of Urology, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Purpose: We aimed to investigate basic information, clinical findings, treatments for tumor, pathology, and outcomes of HIV-positive patients diagnosed with renal cell carcinoma (RCC).

Patients And Methods: We collected 19 patients from 2012 to 2020 who are diagnosed with RCC with HIV-positive. A retrospective analysis was performed on their hospitalization course and tumor-related parameters, including basic information, clinical findings, HIV-associated data, pathology, treatments for tumor, and outcomes. Read More

View Article and Full-Text PDF