Search Our Scientific Publications & Authors

J Urol 2021 Jun 11:101097JU0000000000001911. Epub 2021 Jun 11.

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Purpose: This AUA Guideline focuses on evaluation/counseling/management of adult patients with clinically-localized renal masses suspicious for cancer, including solid-enhancing tumors and Bosniak 3/4 complex-cystic lesions.

Materials/methods: The Renal Mass and Localized Renal Cancer guideline underwent an update literature review which resulted in the 2021 amendment. When sufficient evidence existed, the body of evidence was assigned a strength rating of A (high), B (moderate), or C (low) for support of Strong, Moderate, or Conditional Recommendations. Read More

Int Braz J Urol 2021 Apr 20;47. Epub 2021 Apr 20.

Department of Mongolian Medicine Urology, Affiliated Hospital of Inner Mongolia University for Nationalities, Tongliao,China.

Purpose: The predictors of trifecta achievement in partial nephrectomy (PN) were poorly inquired and remained a controversial area of discovery. To evaluate predictive factors of trifecta achievement in patients undergoing PN.

Materials And Methods: A systematic literature search was performed to identify relevant articles. Read More

Surg Endosc 2021 Jun 11. Epub 2021 Jun 11.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Female gender is known to be protective against acute kidney injury (AKI) after radical or partial nephrectomy and estrogen is considered a protective factor. If estrogen is a major contributor to the protective effects of female gender against renal injury, these protective effects may be diminished in postmenopausal women. Therefore, this retrospective study investigated the influence of female age on gender-related differences in AKI after minimally invasive radical or partial nephrectomy. Read More

Minerva Urol Nephrol 2021 Jun 11. Epub 2021 Jun 11.

Division of Urology, Department of Translational Medicine, Maggiore della Carità Hospital, University of Eastern Piedmont, Novara, Italy -

Background: Prediction of risk of RCC progression after surgery is important for follow-up planning. We identified predictors of progression-free survival (PFS) and cancer-specific survival (CSS) in a large single institutional cohort and investigated patterns and sites of progression according to stage and grade.

Methods: Node-negative non-metastatic clear-cell RCC (ccRCC) patients treated with radical or partial nephrectomy from 2000 to 2020 were included. Read More

Aktuelle Urol 2021 Jun 9. Epub 2021 Jun 9.

Klinik für Urologie und Kinderurologie, Universitätsklinikum des Saarlandes, Homburg/Saar, Deutschland.

Twenty years have passed since the first reports on robot-assisted kidney tumor surgery in 2001. However, robotic surgery has not spread to all German urologic departments yet. Hence, one has to question whether robot-assisted kidney tumor surgery can be considered a standard today. Read More

Medicine (Baltimore) 2021 May;100(19):e25864

Children's Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, Kazan, Russian Federation.

Rationale: Pediatric patients with WTl-associated syndromes (including Wilms' tumor-aniridia syndrome and Denys-Drash syndrome), Perlman syndrome, mosaic aneuploidy, and Fanconi anemia with a biallelic breast cancer type 2 susceptibility protein mutation have the highest risk of developing Wilms' tumor.

Patient Concerns And Diagnosis: We describe a patient with bilateral metachronous Wilms' tumor, ambiguous genitalia characterized by 46, XY disorder of sexual development (DSD) with scrotal hypospadias and bilateral abdominal cryptorchidism, but without nephropathy. At the age of 7 months, the child underwent left nephrectomy with left orchiopexy. Read More

J Surg Case Rep 2021 Jun 4;2021(6):rjab225. Epub 2021 Jun 4.

Colorectal Surgery Unit, Surgery Service, Complejo Asistencial Doctor Sótero Del Río, Santiago 8207257, Chile.

Malakoplakia is a rare disease. Clinical presentation is non-specific, making its diagnosis an incidental finding on histopathological analysis. The aim of this case report is to describe a patient diagnosed with colon, renal and soft tissue malacoplakia mimicking a locally advanced colorectal cancer. Read More

Georgian Med News 2021 Apr(313):12-20

City Clinical Hospital №4, Dnipro, Ukraine.

Objective - to study the character of possible postoperative complications and to define the reason and frequency of postoperative hemorrhage as a complication of partial nephrectomy. From January 2008 to December 2019 were performed 175 partial nephrectomy (PN) by a single surgeon in a high volume center. 41 operations were laparoscopic partial nephrectomy (LPN), 134 - open partial nephrectomy (OPN). Read More

Urol Oncol 2021 Jun 6. Epub 2021 Jun 6.

Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO. Electronic address:

Background: Renal cell carcinoma (RCC) most commonly afflicts older patients while those 40 years old or younger represent an uncommon population. We aim to describe the tumor characteristics and treatment patterns for young kidney cancer patients utilizing the National Cancer Database.

Methods: The National Cancer Database Participant User File for RCC was queried from 2004 to 2016. Read More

Scand J Urol 2021 Jun 7:1-6. Epub 2021 Jun 7.

Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.

Objective: To investigate the safety and efficacy of OTL38, a folate-targeted, intraoperative fluorescence agent, in patients undergoing robotic-assisted laparoscopic partial nephrectomy.

Methods: Patients with proven or suspected localized renal cell carcinoma at a single academic institution were selected from 2016 to 2018. Patients received one dose of OTL38 at 0. Read More

Mol Clin Oncol 2021 Jul 23;15(1):140. Epub 2021 May 23.

The Yale Larynx Laboratory, Department of Surgery, Yale School of Medicine, New Haven, CT 06510, USA.

Renal Cell Carcinoma (RCC) is the most common type of cancer in the kidney and is mostly asymptomatic. Previous studies have supported the important role of sex hormones in RCC pathophysiology and that targeted hormone receptor therapy, such as estrogen receptor targeting, is a promising treatment strategy. However, to the best of our knowledge, it remains unknown whether hormonal therapy, such as controlled ovarian stimulation for fertilization, serves a role in the development and progression of RCC. Read More

Eur Urol 2021 Jun 3. Epub 2021 Jun 3.

Department of Urology, University of Patras, Patras, Greece. Electronic address:

Eur Urol 2021 Jun 1. Epub 2021 Jun 1.

Department of Urology, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Background: Salvage treatment for local recurrence after prior partial nephrectomy (PN) or local tumor ablation (LTA) for kidney cancer is, as of yet, poorly investigated.

Objective: To classify the treatments and standardize the nomenclature of salvage robot-assisted renal surgery, to describe the surgical technique for each scenario, and to investigate complications, renal function, and oncologic outcomes.

Design, Setting, And Participants: Sixty-seven patients underwent salvage robot-assisted renal surgery from October 2010 to December 2020 at nine tertiary referral centers. Read More

BJU Int 2021 Jun 4. Epub 2021 Jun 4.

Urology Unit Careggi Hospital, University of Florence, Florence, Italy.

Objectives: to compare the functional outcomes of on- vs off-clamp robot assisted partial nephrectomy (RAPN) within a randomised controlled trial.

Materials And Methods: the CLOCK (CLamp vs Off Clamp the Kidney during robotic partial nephrectomy; NCT02287987) is a multicentre randomised controlled trial including patients with normal baseline function, two kidneys and masses with RENAL score ≤ 10. Pre- and post-operative renal scintigraphy was prescribed. Read More

Curr Urol 2021 Mar 29;15(1):52-58. Epub 2021 Mar 29.

Department of Urology, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Introduction: Minimally invasive partial nephrectomy is standard of care treatment for small renal masses.

Objective: We evaluated the relationship between subcutaneous and visceral obesity with high-grade postoperative 30-day complications in patients undergoing minimally invasive partial nephrectomy.

Methods: We retrospectively identified 98 patients at our institution from 2014 to 2017 who underwent laparoscopic or robotic-assisted partial nephrectomy due to suspected renal cell carcinoma. Read More

Am J Clin Pathol 2021 Jun 2. Epub 2021 Jun 2.

Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA.

Objectives: Pathologic evaluation of nonneoplastic renal parenchyma in nephrectomy specimens is important for identifying chronic kidney disease and diabetic nephropathy, but increasing utilization of partial nephrectomies has led to less-sampled nonneoplastic parenchyma. The sampled tissue is often composed predominantly of the peritumoral atrophic band (PAB) directly adjacent to the tumor. We sought to determine the characteristics of the PAB and whether it could be used to reliably assess kidney pathology, including diabetic nephropathy. Read More

World J Urol 2021 May 29. Epub 2021 May 29.

Division of Urology, VCU Health, Richmond, VA, 23298-0118, USA.

Purpose: To assess the outcomes of retroperitoneal robot-assisted partial nephrectomy (r-RAPN) in a large cohort of patients with postero-lateral renal masses comparing to those of transperitoneal RAPN (t-RAPN).

Methods: Patients with posterior (R.E. Read More

Cureus 2021 May 23;13(5):e15190. Epub 2021 May 23.

Emergency Medicine, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, SAU.

Xanthogranulomatous pyelonephritis (XGP) is considered to be a rare variant of chronic pyelonephritis, which results in non-functioning kidneys in patients. The exact etiology of this disease is still unknown, and hence even its pathophysiology remains unclear. We present a case of a 27-year-old Saudi male patient who had been bed-bound with a known case of a congenital anomaly with severe kyphoscoliosis, bilateral lower limbs deformity with paraplegia, and a ventriculoperitoneal shunt since childhood. Read More

BJU Int 2021 May 26. Epub 2021 May 26.

Division of Surgery and Interventional Science, University College London.

Renal oncocytoma represents between 6-12% of T1 renal tumours in surgical series (1-2). Contemporary imaging cannot differentiate oncocytoma from malignant renal cell carcinoma (RCC). Uptake of renal tumour biopsy in clinical practice has been variable (3) and surgery with partial or radical nephrectomy is the first-line in the management of RCC (4,5). Read More

World J Surg Oncol 2021 May 25;19(1):156. Epub 2021 May 25.

Department of Urology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

Background: Renal cell carcinoma (RCC) is a common malignant tumour of the genitourinary system. We aimed to analyse the potential value of metastasis-related biomarkers, circulating tumour cells (CTCs) and the proliferative marker Ki-67 in the diagnosis of RCC.

Methods: Data from 24 laparoscopic radical nephrectomies (RNs) and 17 laparoscopic partial nephrectomies (PNs) were collected in 2018. Read More

Clin Nephrol 2021 May 25. Epub 2021 May 25.

Background: A reninoma is a rare benign renal tumor that leads to secondary aldosteronism, secondary hypertension, and hypokalemia due to excessive renin secretion.

Case Presentation: We report a case of a patient presenting with typical endophytic reninoma and describe her diagnosis and treatment. Following 3D reconstruction from computed tomography images combined with pre-operative planning via 3D printing technology, partial nephrectomy was performed; the scope of resection was accurately evaluated to achieve precise tumor excision. Read More

J Korean Med Sci 2021 May 24;36(20):e135. Epub 2021 May 24.

Department of Urology, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Korea.

Background: To compare open partial nephrectomy (OPN) and robot-assisted partial nephrectomy (RAPN) in the management of renal tumors larger than 4 cm.

Methods: Clinical records of 220 patients who underwent OPN or RAPN for a single renal tumor ≥ 4.0 cm with a normal contralateral kidney were reviewed. Read More

Curr Urol Rep 2021 May 25;22(7):36. Epub 2021 May 25.

Department of Urology, L'Institut Mutualiste Montsouris, Paris, France.

Purpose Of Review: To compare laparoscopic partial nephrectomy (LPN) and robot-assisted partial nephrectomy (RAPN) performed in two European tertiary centers using the classic optimal surgical definition - "MIC" - and a new optimal surgical definition: the "Novel TRIFECTA" (NT) concept. We sought to strengthen the PN evidence and to test the NT's performance.

Recent Findings: The study population comprehended 505 cases of localized kidney cancer from two tertiary centers between 2012 and 2019. Read More

World J Urol 2021 May 24. Epub 2021 May 24.

S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China.

Purpose: The COVID-19 pandemic has led to the cancellation or deferment of many elective cancer surgeries. We performed a systematic review on the oncological effects of delayed surgery for patients with localised or metastatic renal cell carcinoma (RCC) in the targeted therapy (TT) era.

Method: The protocol of this review is registered on PROSPERO(CRD42020190882). Read More

Eur Urol Focus 2021 May 21. Epub 2021 May 21.

ORSI Academy, Melle, Belgium; Department of Urology, OLV, Aalst, Belgium.

Yonago Acta Med 2021 May 10;64(2):184-191. Epub 2021 May 10.

Division of Urology, Department of Surgery, School of Medicine, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan.

Background: We evaluated the influence of prior abdominal surgery on perioperative outcomes in patients who underwent robot-assisted partial nephrectomy in initial Japanese series.

Methods: We reviewed patients with small renal tumors who underwent robot-assisted partial nephrectomy from October 2011 to September 2020 at our institution. Patients with prior abdominal surgery were compared with those without prior surgery based on perioperative outcomes. Read More

BMC Cancer 2021 May 24;21(1):592. Epub 2021 May 24.

Department of Urology, Seoul National University Bundang Hospital (SNUBH), 166 Gumi-Ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 463-707, Korea.

Background: There are limited data concerning patients treated with sequential bilateral kidney surgery. Current guidelines still lack an optimal surgical sequencing approach. We evaluated renal functional outcomes after sequential partial nephrectomy (PN) and radical nephrectomy (RN) in patients with bilateral renal cell carcinoma (RCC). Read More

Surg Radiol Anat 2021 May 22. Epub 2021 May 22.

Department of Urology, Faculty of Medicine, Faculty Tunis Manar, Charles Nicolle Hospital, Tunis, Tunisia.

Purpose: Partial nephrectomy is gaining, nowadays, more interest in oncologic kidney surgery. This type of surgery requires the good knowledge of vascular renal anatomy to make it safe and to guarantee good functional and oncological outcomes. This paper exposes the clinical implication of the arterial renal anatomy in nephron-sparing surgery. Read More

Aging (Albany NY) 2021 05 19;13(10):14304-14321. Epub 2021 May 19.

Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

Renal cell carcinoma is characterized by high immunogenicity and infiltration of immune cells. CD45RO+CD8+ T cells are well known as a critical role in host defense of the immune environment. However, their role in clear cell renal carcinoma (ccRCC) remains unknown. Read More

Eur Urol Focus 2021 May 17. Epub 2021 May 17.

Department of Urology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.