45,944 results match your criteria Nephrectomy Partial


Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.

Glycoconj J 2018 Dec 10. Epub 2018 Dec 10.

Department of Metabolic Regulation, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Serum sulfatides are critical glycosphingolipids that are present in lipoproteins and exert anticoagulant effects. A previous study reported decreased levels of serum sulfatides in hemodialysis patients and suggested an association with cardiovascular disease. However, the mechanism of changes in serum sulfatides in chronic kidney dysfunction has not been well investigated. Read More

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December 2018

A non-invasive biomarker of type III collagen degradation reflects ischaemia reperfusion injury in rats.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace the functional tissue. We assessed the concentrations of a neo-epitope fragment of COL III generated by matrix metalloproteinase-9 cleavage (C3M) in two rat models resembling the ischaemic injury taking place following kidney transplantation. Read More

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December 2018

Nephrectomy for Metastatic Kidney Tumor in Patients with Differentiated Thyroid Cancer: A Report of Two Cases.

Case Rep Endocrinol 2018 11;2018:7842792. Epub 2018 Nov 11.

Department of Surgery, Yokohama City University School of Medicine, Yokohama, Japan.

The occurrence of renal tumors originating from thyroid cancer is extremely rare with a few effective treatments for renal metastases. Here, we report the cases of two patients with differentiated thyroid cancer who underwent nephrectomy for a metastatic kidney tumor. Case 1 was a 74-year-old man who was diagnosed with right kidney tumor 10 years after initial surgery for papillary thyroid cancer (PTC). Read More

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November 2018

Radical nephrectomy and intracaval thrombectomy for advanced renal cancer with extensive inferior vena cava involvement utilising cardiopulmonary bypass and hypothermic circulatory arrest: Is it worthwhile?

Arab J Urol 2018 Dec 30;16(4):378-385. Epub 2018 Jul 30.

Department of Urology, University Hospital of Wales, Heath Park, Cardiff, UK.

Objective: To report our long-term outcomes of surgical treatment of renal tumours with inferior vena cava (IVC) tumour thrombus above the hepatic veins, utilising cardiopulmonary bypass (CBP) and hypothermic circulatory arrest (HCA), as surgical resection remains the only effective treatment for renal cancers with extensive IVC tumour thrombus.

Patients And Methods: We retrospectively reviewed 48 consecutive patients (median age 58 years) who underwent surgical treatment for non-metastatic renal cancer with IVC tumour thrombus extending above the hepatic veins. Perioperative, histological, disease-free (DFS) and overall survival (OS) data were recorded. Read More

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December 2018

Comparison of Three-Quadrant Transversus Abdominis Plane Block and Continuous Epidural Block for Postoperative Analgesia After Transperitoneal Laparoscopic Nephrectomy.

Anesth Pain Med 2018 Oct 3;8(5):e80024. Epub 2018 Sep 3.

Department of Anesthesiology and Intensive Care, Universitas Indonesia, Jakarta, Indonesia.

Background: Postoperative pain management is important for the early recovery of the living donor patient. Patient-controlled opioid analgesia, epidural analgesia, or a combination of both is the preferred pain management after abdominal surgery although these approaches have serious side effects. The transversus abdominis plane (TAP) block has been increasingly used for postoperative pain management and the addition of dexamethasone to local anesthetic can prolong the duration of action. Read More

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October 2018

Birt-Hogg-Dubé Syndrome Caused by a Novel Mutation in the FLCL Gene.

Case Rep Genet 2018 7;2018:4173704. Epub 2018 Nov 7.

Medical Corps, United States Navy, Pulmonary Department, Naval Medical Center, San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.

Background: Birt-Hogg-Dubé syndrome is a genetic disorder characterized by skin fibrofolliculomas, cystic lung disease, and bilateral renal tumors. It has also been implicated in the formation of tumors in other organs, particularly thyroid and colon. This case presents a young female presenting with only cystic lung disease and kidney tumors, identified as having a never before identified heterozygous mutation in the folliculin () gene which is the likely cause of her syndrome. Read More

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November 2018

Maxillary Sinus Mass as First Presentation of Silent Metastatic Renal Cell Carcinoma.

J Craniofac Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Otolaryngology, University of Foggia, Foggia.

Renal cell carcinoma accounts for more than 3% of all malignant diseases. Metastatic disease to the head and neck ranges from 15% to 30%. The 5-year survival rate after nephrectomy is 60% to 75%, but with multiorgan metastases the 5-year survival rate is significantly lower, 0% to 7%. Read More

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December 2018

Trends in the treatment of clinical T1 renal cell carcinoma for octogenarians: Analysis of the National Cancer Database.

J Geriatr Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO, United States. Electronic address:

Objective: Treatment of renal cell carcinoma has evolved with emphasis on nephron preservation for small renal masses. Our objective was to evaluate the proportions of treatment types for octogenarians with clinical stage 1 renal cell carcinoma.

Materials And Methods: The National Cancer Database was analyzed from 2004 to 2015. Read More

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December 2018

Renal cell carcinoma and brain metastasis: Questioning the dogma of role for cytoreductive nephrectomy.

Urol Oncol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, SUNY Upstate Medical University, Syracuse, NY; Department of Urology, SUNY Upstate Medical University, Syracuse, NY. Electronic address:

Introduction: Renal cell carcinoma (RCC) brain metastasis is generally viewed as poor prognostic features and often excludes patients from cytoreductive nephrectomy or participation in clinical trials. We aim to evaluate patients presenting with brain metastasis and their outcomes.

Methods: Surveillance Epidemiology and End Results-18 registries database was queried for all patients with metastatic RCC from 2010 to 2014. Read More

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December 2018

Evolution of Robot-assisted Partial Nephrectomy: Techniques and Outcomes from the Transatlantic Robotic Nephron-sparing Surgery Study Group.

Eur Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Onze-Lieve-Vrouw Hospital, Aalst, Belgium; ORSI Academy, Melle, Belgium.

Background: Robot-assisted partial nephrectomy (RAPN) is considered a feasible minimally invasive alternative to open partial nephrectomy (OPN) for the surgical treatment of renal tumors.

Objective: To provide further evidence supporting the effectiveness of RAPN in a contemporary patient population treated at one of three tertiary care centers for robotic surgery and to describe the evolution of RAPN-based technical improvements.

Design, Setting, And Participants: The Transatlantic Robotic Nephron-sparing Surgery (TRoNeS) study group prospectively collected data from 635 patients subjected to RAPN for clinically localized kidney cancer between 2010 and 2016 at three high-volume tertiary care centers. Read More

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December 2018

Outcome of sentinel lymph node biopsy in patients with clinically non-metastatic renal cell carcinoma.

Scand J Urol 2018 Dec 11:1-8. Epub 2018 Dec 11.

a Department of Urology, The Netherlands Cancer Institute , Amsterdam , The Netherlands.

Objective: To investigate the rate of occult SN metastases, oncological outcome, and association of recurrence with the pattern of lymphatic tumour drainage in RCC.

Materials And Methods: A pooled RCC sub-group analysis was conducted of secondary endpoints from a published feasibility and a phase II prospective single-arm SN study to investigate oncological outcome. Patients with cT1-3 (<10 cm) cN0M0 RCC of any sub-type were enrolled. Read More

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December 2018
1 Read

Immunohistochemical expressionof sodium-dependent glucose transporter - 2 (SGLT-2) in clear cell renal carcinoma: possible prognostic implications.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Urology, Dokkyo Medical University, Tochigi, Japan.

Purpose: Glucose is a major energy resource for tumor cell survival and growth, and its influx into cells is mainly carried out by facilitative glucose transporters (GLUTs). Sodium - dependent glucose transporters (SGLTs) have been highlighted as playing important roles in diabetic treatment. However, their potential roles in cancer remain unclear. Read More

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October 2018

Predictors of surgical complications of nephrectomy for urolithiasis.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Divisão de Urologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.

Objectives: Nephrectomy due to stone disease may be a challenging procedure owing to the presence of significant inflammation and infection, involving high complication rate. The objective of our study was to identify predictors for complications of nephrectomy for urolithiasis.

Patients And Methods: A retrospective review of 149 consecutive patients > 18y submitted to simple nephrectomy for urolithiasis from January 2006 to July 2012 was performed. Read More

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October 2018

Incidence of surgical wound infection in renal surgery. The effect of antibiotic prophylaxis appropriateness. A prospective cohort study.

Actas Urol Esp 2018 Dec 7;42(10):639-644. Epub 2018 Jul 7.

Unidad de Medicina Preventiva, Hospital Universitario Fundación Alcorcón, Alcorcón, Madrid, España; Centro de Salud Los Cármenes, Madrid, España; Departamento de Medicina Preventiva y Salud Pública, Universidad Rey Juan Carlos, Alcorcón, Madrid, España. Electronic address:

Objective: To assess compliance with the antibiotic prophylaxis protocol for patients who underwent renal surgery and its effect on the incidence of surgical wound infection.

Material And Methods: We performed a prospective cohort study and assessed the overall compliance and each aspect of the antibiotic prophylaxis (start, administration route, antibiotic of choice, duration and dosage) and reported the compliance rates. The qualitative variables were compared with the chi-squared test, and the quantitative variables were compared with Student's t-test. Read More

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December 2018

En bloc laparoscopic radical nephrectomy with inferior vena cava thrombectomy: A single-institution experience.

Int J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Objective: To report the outcomes of laparoscopic radical nephrectomy with inferior vena cava thrombectomy for right renal cell carcinoma at Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan.

Method: A retrospective review of the clinical records of five patients who underwent laparoscopic radical nephrectomy with inferior vena cava thrombectomy for right renal cell carcinoma between 2013 and 2017 was carried out. The surgical procedure included ligation and cutting of the right renal artery, followed by kidney mobilization. Read More

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December 2018
2 Reads

2018 Update on Medical Overuse.

JAMA Intern Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine and Center for Health Policy and Outcomes, Memorial Sloan Kettering Cancer Center, New York, New York.

Importance: Overuse of medical care is a well-recognized problem in health care, associated with patient harm and costs. We sought to identify and highlight original research articles published in 2017 that are most relevant to understanding medical overuse.

Observations: A structured review of English-language articles published in 2017 was performed, coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adult care. Read More

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December 2018
13 Reads

Is transperitoneal laparoscopic radical nephrectomy suitable for patients with a history of abdominal surgery?

Asian J Endosc Surg 2018 Dec 2. Epub 2018 Dec 2.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Laparoscopic radical nephrectomy is the gold standard for treatment of renal cell carcinoma. However, previous abdominal surgery is generally regarded as a contraindication to the laparoscopic approach because it causes intraperitoneal adhesions, which are thought to interfere with subsequent laparoscopic procedures inside the abdominal cavity. Few studies have examined the influence of prior surgery on laparoscopic nephrectomy. Read More

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December 2018

Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis.

Intern Med Rev (Wash D C) 2018 Oct;4(10)

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205.

Given the inherent heterogeneity of the septic patient population and possible comorbid conditions, it is not surprising that the influence of gender on incidence and outcomes are still unclear. The goal of this study was to use a clinically relevant murine model of sepsis, cecal ligation and puncture (CLP) in CD1 mice, with and without uniphrectomy as a comorbid condition to investigate possible gender differences in renal mitochondrial function and dynamics. High resolution respirometry on fresh kidney biopsies was used to measure renal respiratory complex activities. Read More

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October 2018

Successful Treatment of the Gastrointestinal Manifestation of Prototheca in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2018 Aug 10. Epub 2018 Aug 10.

Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary.

Introduction: The Prototheca species are achlorophyllic algae and they are recognized pathogens in animals. They have been reported to cause infections in humans; the majority of the infected patients are immunocompromised. Organ transplant recipients are at risk of infection caused by such unusual organisms. Read More

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Economic Burden of Metastatic Clear-Cell Renal Cell Carcinoma for French Patients Treated With Targeted Therapies.

Clin Genitourin Cancer 2018 Nov 7. Epub 2018 Nov 7.

Department of Pharmacy, University Hospital, Besançon, France; INSERM, EFS BFC, UMR1098, Interactions hôte-greffon-tumeur, Ingénierie Cellulaire et Génique, University Bourgogne Franche-Comté, Besançon, France. Electronic address:

Background: Targeted therapies have transformed the treatment of metastatic clear-cell renal cell carcinoma (mccRCC). Despite the importance of mccRCC, studies on its economic burden in daily practice are sparse. The purpose of this retrospective study was to evaluate cost of illness for 224 patients with mccRCC included in the cohort published by Thiery-Vuillemin et al (Factors influencing overall survival for patients with metastatic clear-cell renal cell-carcinoma in daily practice. Read More

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November 2018
1 Read

Predictors of complications following retroperitoneoscopic total and partial nephrectomy.

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

The Royal Hospital for Children, Glasgow, Scotland. Electronic address:

Introduction: Recent reports in the literature suggest an increased risk of complications with retroperitoneal as opposed to transperitoneal approach to partial nephrectomy (PN) and total nephrectomy (TN). We are a large unit performing predominantly retroperitoneoscopic PN and TN. We aim to review our outcomes and perform analysis to elucidate the predictors of complications following the retroperitoneal approach for extirpative kidney surgery. Read More

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November 2018
1 Read

A Comparison of Excisional Volume Loss Calculation Methods to Predict Functional Outcome After Partial Nephrectomy.

J Endourol 2018 Dec 1. Epub 2018 Dec 1.

Icahn School of Medicine at Mount Sinai, Urology, New York, New York, United States ;

Introduction Functional parenchymal kidney volume loss (FVL) is a significant predictor of kidney function decline after partial nephrectomy (PN). Here, we sought to assess two different methods for quantifying FVL post PN: imaging based tissue segmentation (TS) vs. ex vivo analysis. Read More

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December 2018

Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window1.

Acta Cir Bras 2018 Nov;33(11):1016-1026

Veterinay Medical, Animal Experimentation Division, Clinical Hospital, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre-RS, Brazil. Substantive scientific and intellectual contributions to the study, critical revision.

Purpose: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell.

Methods: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal). Read More

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November 2018

Association of Prevalence of Benign Pathologic Findings After Partial Nephrectomy With Preoperative Imaging Patterns in the United States From 2007 to 2014.

JAMA Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, Stanford University Medical Center, Stanford, California.

Importance: Although the intent of nephron-sparing surgery is to eradicate malignant tumors found on preoperative imaging, benign masses often cannot be differentiated from malignant tumors. However, in the past there have been discrepancies in the reported percentages of benign masses removed by partial nephrectomy (PNx).

Objective: To investigate the annual trend of prevalence of benign pathologic findings after PNx and to investigate what potential factors are associated with this prevalence. Read More

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December 2018

[Cytoreductive nephrectomy for metastatic renal cell carcinoma - obsolete?]

Urologe A 2018 Dec 4. Epub 2018 Dec 4.

Urologische Klinik und Poliklinik, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.

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December 2018

Factors Influencing Cyst Infection in Autosomal Dominant Polycystic Kidney Disease.

Nephron 2018 Dec 4:1-12. Epub 2018 Dec 4.

Department of Nephrology, Toranomon Hospital, Tokyo, Japan.

Background: Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often difficult to treat. However, the factors influencing cyst infection are still unknown. Therefore, we investigated clinical factors related to the duration of hospitalization and death due to cyst infection. Read More

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December 2018
5 Reads

An analysis of SPECT/CT non-visualization of sentinel lymph nodes in renal tumors.

EJNMMI Res 2018 Dec 3;8(1):105. Epub 2018 Dec 3.

Department of Urology, The Netherlands Cancer Institute, Postbus 90203, 1006 BE, Amsterdam, The Netherlands.

Background: Sentinel lymph node biopsy (SLNB) after intratumoral injection of Tc labeled nanocolloid and imaging with scintigraphy and SPECT/CT in renal tumors is feasible. However, sentinel lymph node (SN) non-detection rate with scintigraphy and SPECT/CT is high. The aim of the study was to determine factors affecting non-visualization (NV) of SN imaging in renal tumors. Read More

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December 2018

Segmental testicular infarction following nephrectomy.

Radiol Case Rep 2019 Feb 28;14(2):278-281. Epub 2018 Nov 28.

Department of Radiology, Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, Whitechapel, E1 1BB, UK.

Segmental testicular infarction is a rare diagnosis and there are few documented cases in the literature. Those cases that have been reported are usually in the setting of epididymitis, hypercoaguable states, vasculitis, sickle cell disease, post orchidopexy or vasectomy, and idiopathic. We report a case of a patient who developed segmental testicular infarction that was managed conservatively, following nephrectomy for a ruptured kidney and the associated ultrasonographic appearances. Read More

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February 2019

Preoperative apolipoprotein B/A1 ratio is an independent prognostic factor in metastatic renal cell carcinoma.

Urol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, PR China. Electronic address:

Objectives: We aimed to explore the prognostic value of preoperative apolipoprotein B/apolipoprotein A1 (Apo B/A1) ratio in metastatic renal cell carcinoma (mRCC).

Materials And Methods: Between January 2006 and December 2016, patients with mRCC who underwent cytoreductive nephrectomy at the Chinese PLA General Hospital were enrolled. The clinical-pathological parameters were collected retrospectively, and the preoperative Apo B/A1 ratios of two different subgroups were compared. Read More

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November 2018

Predictive value of preoperative monocyte-lymphocyte ratio among patients with localized clear renal cell carcinoma of ≤7 cm on preoperative imaging.

Medicine (Baltimore) 2018 Nov;97(48):e13433

Department of Urology and Urological Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

We investigated the prognostic ability of preoperative monocyte-lymphocyte ratio for oncologic outcomes in non-metastatic clear cell renal cell carcinoma of ≤7 cm on preoperative computed tomography (CT).We retrospectively reviewed 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤7 cm (2005-2014). We included 1137 patients after exclusion of benign pathology, non-clear cell, morbidity affecting inflammatory markers, metastasis, regional lymphadenopathy, positive margin, and follow up <12 months. Read More

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November 2018

Management of Patients with renal mass lesions based on renal biopsy cytology results.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

Northwestern University, Chicago, IL. Electronic address:

The benefit of renal biopsy, especially in patients with a history of malignancy (HOM), has not been well-studied. We studied the clinical management of 339 renal masses following fine needle aspirate (FNA) and/or core needle biopsy (CNB) with touch preparation. 41% of patients had HOM, which did not increase the incidence of renal malignancy. Read More

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November 2018
1 Read

Adjuvant therapy after nephrectomy for renal cell carcinoma.

Authors:
Alain Ravaud

Asia Pac J Clin Oncol 2018 Nov;14 Suppl 5:33-36

Department of Medical Oncology, Hôpital Saint-André, Bordeaux, France.

Adjuvant treatment with vascular endothelial growth factor receptor tyrosine kinase inhibitor in renal cell carcinoma after nephrectomy has been reported through three clinical trials: S-TRAC, ASSURE and PROTECT. Only S-TRAC has been significantly positive on primary end-point disease-free survival under sunitinib compared to placebo, whereas ASSURE and PROTECT did not show any gain under sunitinib, sorafenib or pazopanib. This short review presents the differences between the trials and provides hypotheses on why S-TRAC may have been positive. Read More

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November 2018
4 Reads

Efficacy, safety, and prognostic indicators of first-line sunitinib in patients with metastatic renal cell carcinoma: A single center experience.

J Cancer Res Ther 2018 Oct-Dec;14(6):1303-1311

Department of Clinical Oncology, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Background: We assessed the efficacy and safety of sunitinib as the first-line treatment in metastatic renal cell carcinoma (mRCC) patients. The predictors of survival and efficacy in mRCC as identified from previous studies, including the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic RCC Database Consortium (IMDC) factors, were also evaluated.

Patients And Methods: Data from 56 patients with mRCC, treated with sunitinib at our institute (2006-2014), were analyzed retrospectively. Read More

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November 2018
1 Read

Clinicopathological Features and Survival Data of Localized Renal Masses in Young Adults

Asian Pac J Cancer Prev 2018 Nov 29;19(11):3233-3236. Epub 2018 Nov 29.

Department of Urology, Medical Faculty, Yuzunci Yıl University, Van, Turkey. Email:

Purpose: Renal tumors are rarely seen in young adults. In this study, was aimed to report the data of 18-40 years old patients with Renal Cell Carcinoma (RCC) whom we operated. Material and Method: We retrospectively reviewed the data of patients between the ages of 18 and 40 years old patients who have renal masses. Read More

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November 2018
3 Reads

[Diagnosis and management of small solid renal masses].

Rev Med Suisse 2018 Nov;14(629):2160-2163

Service d'urologie, Département de chirurgie, HUG, 1211 Genève 14.

Discovery of small solid renal masses via echography, CT-scan or MRI is common in current medical practice, with more than 70 % found incidentally. Although they include benign lesions, most are renal cell carcinomas. A radiological assessment, associated if necessary with a percutaneous renal biopsy, leads to their diagnosis in the vast majority of cases. Read More

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November 2018

A family with PTEN mutations with malignancy and an unusually high number of offspring with autism spectrum disorder: a case report.

J Med Case Rep 2018 Nov 28;12(1):353. Epub 2018 Nov 28.

Institute of Cardiovascular Research, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK.

Background: Cowden's syndrome (OMIM:158350), a rare genetic disorder (incidence ~ 1:250,000), is caused by mutations of the tumor suppressor gene PTEN. In this report, we describe clinical manifestations of a 56-year-old patient diagnosed with Cowden's syndrome and his family with PTEN mutations. The family has an unusually high number of offspring with autism spectrum disorder. Read More

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November 2018
1 Read

SDH-deficient renal cell carcinoma - clinical, pathologic and genetic correlates: a case report.

BMC Urol 2018 Nov 27;18(1):109. Epub 2018 Nov 27.

Division of Urology, Department of Surgery, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.

Background: Succinate dehydrogenase (SDH)- deficient renal cell carcinoma (RCC) is a newly identified rare subtype of RCC, having only gained acceptance from the World Health Organization in 2016. To the best of our knowledge, there are only 55 reported cases worldwide. Here, we report a new case of SDH-deficient RCC. Read More

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November 2018
3 Reads

The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis.

J Cell Physiol 2018 Nov 27. Epub 2018 Nov 27.

Cardiac Surgery and Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The interplay between H S and nitric oxide (NO) is thought to contribute to renal functions. The current study was designed to assess the role of NO in mediating the renoprotective effects of hydrogen sulfide in the 5/6 nephrectomy (5/6 Nx) animal model. Forty rats were randomly assigned to 5 experimental groups: (a) Sham; (b) 5/6 Nx; (c) 5/6Nx+sodium hydrosulfide-a donor of H S, (5/6Nx+sodium hydrosulfide [NaHS]); (d) 5/6Nx+NaHS+ L-NAME (a nonspecific nitric oxide synthase [NOS] inhibitor); (e) 5/6Nx+NaHS+aminoguanidine (a selective inhibitor of inducible NOS [iNOS]). Read More

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November 2018
1 Read

Predicting Renal Function Outcomes After Partial and Radical Nephrectomy.

Eur Urol 2018 Nov 23. Epub 2018 Nov 23.

Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Partial nephrectomy (PN) is generally favored for cT1 tumors over radical nephrectomy (RN) when technically feasible. However, it can be unclear whether the additional risks of PN are worth the magnitude of renal function benefit.

Objective: To develop preoperative tools to predict long-term estimated glomerular filtration rate (eGFR) beyond 30d following PN and RN, separately. Read More

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November 2018
6 Reads

Chronic kidney cortical damage is associated with baseline kidney function and albuminuria in patients managed with radical nephrectomy for kidney tumours.

Pathology 2018 Nov 23. Epub 2018 Nov 23.

Princess Alexandra Hospital, Brisbane, Qld, Australia; Centre for Kidney Disease Research, University of Queensland, Brisbane, Qld, Australia; Translational Research Institute, Brisbane, Qld, Australia.

This study evaluated the relationship between histological markers of chronic kidney damage in patients undergoing radical nephrectomy for kidney tumours and preoperative kidney function, degree of albuminuria, and changes in glomerular volume. A schema to grade chronic kidney damage could be used to identify patients at risk of developing CKD following nephrectomy. Non-neoplastic cortical tissue was sourced from 150 patients undergoing radical nephrectomy for suspected kidney cancer. Read More

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November 2018
11 Reads

Mono, bi- and tri-exponential diffusion MRI modelling for renal solid masses and comparison with histopathological findings.

Cancer Imaging 2018 Nov 26;18(1):44. Epub 2018 Nov 26.

Magnetic Detection & Imaging, University of Twente, Drienerlolaan 5, 7522 NB, Enschede, Netherlands.

Purpose: To compare diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM), and tri-exponential models of the diffusion magnetic resonance imaging (MRI) signal for the characterization of renal lesions in relationship to histopathological findings.

Methods: Sixteen patients planned to undergo nephrectomy for kidney tumour were scanned before surgery at 3 T magnetic resonance imaging (MRI), with T-weighted imaging, DTI and diffusion weighted imaging (DWI) using ten b-values. DTI parameters (mean diffusivity [MD] and fractional anisotropy [FA]) were obtained by iterative weighted linear least squared fitting of the DTI data and bi-, and tri-exponential fit parameters (D, fand D, ff) using a nonlinear fit of the multiple b-value DWI data. Read More

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November 2018
2 Reads

Effect of Combined Treatment of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-Reperfusion Injury in Patients Undergoing Partial Nephrectomy: Pilot Study.

J Clin Med 2018 Nov 23;7(12). Epub 2018 Nov 23.

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine, Suwon 164, Korea.

We evaluated postoperative renal function in patients with/without combined therapy of ketorolac and remote ischemic preconditioning during partial nephrectomy. Sixteen patients were randomly allocated to either the ketorolac combined with RIPC group (KI, = 8) or control group ( = 8). The KI group received both remote ischemic preconditioning before surgery and intravenous ketorolac of 1 mg/kg before renal artery clamping. Read More

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November 2018
1 Read

Gadolinium tissue deposition in the periodontal ligament of mice with reduced renal function exposed to Gd-based contrast agents.

Toxicol Lett 2018 Nov 23;301:157-167. Epub 2018 Nov 23.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy. Electronic address:

Gadolinium deposition in tissue is linked to nephrogenic systemic fibrosis (NSF): a rare disorder occurring in patients with severe chronic kidney disease and associated with administration of Gd-based contrast agents (GBCAs) for Magnetic Resonance Imaging (MRI). It is suggested that the GBCAs prolonged permanence in blood in these patients may result in a Gd precipitation in peripheral or central organs, where it initiates a fibrotic process. In this study we investigated new sites of retention/precipitation of Gd in a mouse model of renal disease (5/6 nephrectomy) receiving two doses (closely after each other) of a linear GBCA. Read More

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November 2018
3 Reads

Pediatric partial nephrectomy for upper urinary tract duplication anomalies: a comparison between different surgical approaches and techniques.

Urology 2018 Nov 23. Epub 2018 Nov 23.

Division of Pediatric Urology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Objective: To review and compare four different surgical approaches for partial nephrectomy of a nonfunctioning moiety in children with upper urinary tract duplication anomalies.

Materials And Methods: A retrospective review of all pediatric patients who underwent open (OPN), laparoscopic (LPN), robotic (RPN), or laparoendoscopic single site (LESS-PN) partial nephrectomy for the treatment of a nonfunctioning moiety in a duplicated collecting system at two medical centers between 2007 and 2017. Patient demographics, perioperative data, surgical techniques, complications, and results were compared. Read More

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November 2018
4 Reads

Rare cases of ectopic ureter: Analysis from a single centre with review of the literature.

Turk J Urol 2018 Nov 21:1-6. Epub 2018 Nov 21.

Department of Urology, Institute of Post Graduate Medical Education and Research, Kolkata, India.

Objective: Purpose of our study was to aggregate and analyse rare cases of Ectopic Ureter (EU), their association with other anomalies, clinical features, diagnosis and management.

Material And Methods: A total of nine patients with rare presentation of EU were evaluated. Combination of endoscopic and imaging modalities was used as required to define the anatomy and devise the best surgical approach in these cases. Read More

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November 2018
2 Reads

Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports.

J Med Case Rep 2018 Nov 25;12(1):351. Epub 2018 Nov 25.

Department of Radiation Therapy, Centre Léon Bérard, Lyon, France.

Background: Renal cell carcinoma represents 3-5% of adult malignant tumors. Metastases are found in 30-40% of patients and brain metastases occurred in more than 10% of them. Despite significant progress in medical treatment, patients with brain metastases still have a limited survival. Read More

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November 2018
2 Reads

Robot-assisted resection of ectopic kidney in children: An anatomical illustration.

J Pediatr Urol 2018 Oct 27. Epub 2018 Oct 27.

Department of Urology, Ghent University Hospital, Belgium. Electronic address:

Introduction: Failure of kidney migration during embryonic life results in an ectopic kidney, with an incidence varying from 1 in 500 to 1 in 1200. Pelvic kidney can be a rare cause of recurrent urinary tract infection (UTI), warranting nephrectomy in some cases.

Material And Methods: A 7-year-old girl with a history of recurrent UTIs and vaginal discharge was diagnosed with a dysplastic afunctional ectopic kidney located in the pelvis, with ureter draining into the cervix or vaginal wall. Read More

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October 2018
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Assessment of volume preservation performed before or after partial nephrectomy accurately predicts postoperative renal function: Results from a prospective multicenter study.

Urol Oncol 2019 Jan 23;37(1):33-39. Epub 2018 Nov 23.

Michigan State University College of Human Medicine, Grand Rapids, MI; Spectrum Health Hospital System, Grand Rapids, MI. Electronic address:

Purpose: Partial nephrectomy (PN) is standard for small renal masses, improving renal function by preserving renal parenchyma compared with radical nephrectomy. Recent work demonstrated that postoperative surgeon assessment of volume preservation (SAVP) and 3D imaging measurements agree and correlate with postoperative function. We hypothesize preoperative assessment of volume preservation (PAVP) with PN based on preoperative imaging will reliably indicate postoperative renal function. Read More

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January 2019
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[French ccAFU guidelines - Update 2018-2020: Management of kidney cancer].

Prog Urol 2018 Nov 26;28(12S):S3-S31. Epub 2018 Oct 26.

Comité de cancérologie de l'Association française d'urologie, groupe rein, maison de l'urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital européen Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

Objective: To update the French guidelines on kidney cancer.

Methods: A systematic review of the literature between 2015 and 2018 was performed. The most relevant articles regarding the diagnosis, the classification, surgical treatment, medical treatment and follow-up of kidney cancer were retrieved and included in the new guidelines. Read More

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November 2018
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Pure Single-Site Robot-Assisted Partial Nephrectomy Using The SP Surgical System: Initial Clinical Experience.

Urology 2018 Nov 22. Epub 2018 Nov 22.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: To describe the technique of pure single-site trans-peritoneal robotic partial nephrectomy using the da Vinci SP surgical system.

Methods: Three consecutive patients who were diagnosed with contrast-enhanced renal masses amenable of partial nephrectomy were scheduled for robot-assisted partial nephrectomy to be performed using the SP Surgical System. Data collection received institutional review board approval (IRB 13-780). Read More

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November 2018
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