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J Urol 2022 Jun 24:101097JU0000000000002837. Epub 2022 Jun 24.

Department of Urology, Mayo Clinic, Rochester MN.

Purpose: Conversions from partial (PN) to radical nephrectomy (RN) are uncommon and reports on this topic are rare. In this study we present a detailed analysis of conversions from PN to RN in a single institutional contemporary experience and provide an analysis of preoperative risk factors.

Materials And Methods: Patients who underwent converted (cases) and completed (controls) PN from 2000 to 2015 were matched 1:1 for analysis. Read More

Hinyokika Kiyo 2022 May;68(5):133-138

The Department of Renal and Urologic Surgery, Asahikawa Medical University.

Robot-assisted laparoscopic partial nephrectomy (RAPN) is being used in Japan as a less invasive procedure. RENAL nephrometry (RN) score, Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) Classification and Simplified PADUA Renal (SPARE) nephrometry system are tumor-specific morphometry scoring systems used for predicting the difficulty of partial nephrectomy. Adherent perinephric fat (APF) is one of the patient-specific factors related to the difficulty of partial nephrectomy. Read More

Cancers (Basel) 2022 Jun 20;14(12). Epub 2022 Jun 20.

Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.

Background: To compare the intraoperative and postoperative outcomes of indocyanine green (ICG) administration in robot-assisted partial nephrectomy (RAPN) and report the differences in the results between patients with benign and malignant renal tumors.

Methods: From 2017 to 2020, 132 patients underwent RAPN at our institution, including 21 patients with ICG administration. Clinical data obtained from our institution's RAPN database were retrospectively reviewed. Read More

World J Surg Oncol 2022 Jun 23;20(1):213. Epub 2022 Jun 23.

Department of Urology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, NO. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.

Background: For patients with prior intra-abdominal surgery or multiple arteries, the retroperitoneal robot-assisted partial nephrectomy (rRAPN) is a better choice. The renal ventral tumor poses an additional challenge due to poor tumor exposure. This study is determined to assess the feasibility of an internal traction technique (ITT) in rRAPN for the management of renal ventral tumors. Read More

ANZ J Surg 2022 Jun 22. Epub 2022 Jun 22.

Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.

J Endourol 2022 Jun 21. Epub 2022 Jun 21.

Cleveland Clinic Foundation, Glickman Urologic Institute, 9500 Euclid Ave, Cleveland, Ohio, United States, 44195;

Introduction: As the experience with robot assisted partial nephrectomy (RAPN) grows, the indications have expanded to incorporate previously operated ipsilateral kidneys with recurrent renal masses. We sought to analyze the outcomes of redo RAPN in patients with a recurrent renal mass.

Methods: Using a multi-institutional series, the data of 72 patients who underwent RAPN for a recurrent renal mass between 2010 and 2020 were retrospectively analyzed. Read More

BJU Int 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Objectives: To prospectively compare robotically administered transperitoneal transversus abdominis plane to ultrasound-guided TAP (UTAP) to local anesthesia (LA) for pain control and narcotic use in robotic prostatectomy (RP) and robotic partial nephrectomy (RPN) patients.

Subjects/patients And Methods: Patients undergoing RP or RPN were randomized in a single blind 2:2:1 fashion to RTAP:UTAP:LA, with the study powered to evaluate superiority of UTAP to LA and non-inferiority of RTAP to UTAP. We compared time to deliver the block, operating room time, postoperative pain scores using the visual analog scale (VAS), and intraoperative and postoperative analgesia consumption. Read More

CEN Case Rep 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing, Dongcheng, Beijing, 100730, China.

In very rare cases, horseshoe kidney can present simultaneously with renal hemangioma. Nephron-sparing surgery (NSS) is a minimally invasive surgical procedure for horseshoe kidney with tumor, but it is difficult to operate and has not been reported. We report a 71-year-old female with imaging examination revealed an unexpected horseshoe kidney malformation and a cystic mass in the right kidney before her bladder cancer surgery. Read More

World J Urol 2022 Jun 21. Epub 2022 Jun 21.

Department of Urology, Université de Bordeaux, CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France.

Purpose: Robot-assisted partial nephrectomy (RAPN) reduces morbidity, enabling development of Enhanced Recovery After Surgery (ERAS) and day-case protocols. Additional financial costs limit its integration into clinical practice. We evaluated the medico-economic impact of RAPN using a nurse-led coordinated pathway of care (NLC-RAPN). Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Urology, Barwon Health, Geelong, Victoria, Australia.

A man in his 60s was referred to the urology department with an incidental finding of large 75 mm mass within a horseshoe kidney. CT imaging highlighted the well-known aberrant arterial anatomy seen in horseshoe kidney which often causes significant surgical challenges.After careful preoperative planning, the mass was resected successfully during a robot-assisted partial nephrectomy. Read More

Hum Pathol 2022 Jun 17. Epub 2022 Jun 17.

Department of Pathology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Papillary renal neoplasm with reverse polarity (PRNRP) is a newly documented renal entity with an easily recognizable morphology, distinct immunohistochemical profiles, and frequent KRAS mutations. The latest practice guidelines regard PRNRP as a subtype of papillary renal cell carcinoma due to the documented chromosomal alterations of 7, 17, and Y. This study included 20 patients with PRNRP and 30 patients with PRCC. Read More

World J Urol 2022 Jun 20. Epub 2022 Jun 20.

Urology Department of Bordeaux, Bordeaux, France.

Purpose: The management of solitary kidney tumors is a surgical challenge, requiring irreproachable results on both oncological and functional outcomes. The goal of our study was to compare the perioperative results of robotic-assisted partial nephrectomy (RAPN) to open surgery in this indication.

Methods: We led a multicentric study based on the prospectively maintained French national database UroCCR. Read More

BMC Vet Res 2022 Jun 20;18(1):233. Epub 2022 Jun 20.

Department of Small Animal Surgery, Section of Small Animal Clinical Studies, University College Dublin, Belfield, Dublin 4, Ireland.

Background: Canine intrarenal cystic lesions (ICLs) are infrequently reported in the veterinary literature. Several treatment options have been described including cyst fenestration (partial nephrectomy/deroofing) +/- omentalization, sclerotherapy using alcohol as a sclerosing agent, percutaneous cyst drainage (PCD), and ureteronephrectomy. Information regarding presenting clinical signs, physical examination findings, histologic diagnosis and outcomes of dogs with ICLs treated by different methods is limited. Read More

Clin Genitourin Cancer 2022 May 18. Epub 2022 May 18.

Department of Medicine, University of New South Wales, Sydney, Australia.

Introduction: Selective internal radiation therapy (SIRT) is a potential treatment of primary renal cell carcinoma (RCC) deemed unsuitable for conventional therapy. RESIRT is the first-in-human study to evaluate safety and feasibility of SIRT for primary RCC.

Patients And Methods: Patients with RCC, unsuitable for, or who declined conventional therapy, were eligible. Read More

Int J Urol 2022 Jun 15. Epub 2022 Jun 15.

Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: Robot-assisted partial nephrectomy is widely performed for small renal masses, achieving excellent perioperative and intermediate oncological outcomes. However, long-term oncological, functional, and quality of life outcomes after robot-assisted partial nephrectomy remain unclear. In this study, we aimed to evaluate quality of life at 1 year and oncological and functional outcomes of robot-assisted partial nephrectomy after a minimum follow-up of 5 years. Read More

Transl Cancer Res 2022 May;11(5):1141-1145

Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: As the development of various imaging techniques, the incidental detection of renal masses is increasing. Laparoscopic partial nephrectomy (LPN) is the current standard of treatment for renal carcinoma. Though the retroperitoneal laparoscopic partial nephrectomy (RLPN) become the prior choice, the edge of lateroconal fascia blocks the sight and make operation more challenging. Read More

Nephrol Dial Transplant 2022 Jun 15. Epub 2022 Jun 15.

Department of Urology, Aalborg University Hospital, Aalborg, Denmark.

Kidney surgery often includes organ ischemia with risk of acute kidney injury. The present study tested if treatment with combined angiotensin II-AT1 receptor and neprilysin blocker Entresto® (LCZ696-sacubitril/valsartan) protects filtration barrier and kidney function after ischemia and partial nephrectomy in pigs. Single kidney glomerular filtration rate (GFR) by technetium-99m-diethylene-triamine-pentaasetate ([99mTc]Tc-DTPA) clearance was validated (n = 6). Read More

World J Surg Oncol 2022 Jun 15;20(1):202. Epub 2022 Jun 15.

Department of Urology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Introduction: Warm ischemia time (WIT) is a primary concern for robot-assisted laparoscopic partial nephrectomy (RALPN) patients because longer WIT is significantly associated with postoperative deteriorating kidney function. Tumor complexity, determined by the RENAL nephrometry score (RENAL score), can help predict surgical outcomes, but it is unclear what RENAL score and clinical factors affect WIT. This study explored the clinical factors predicting long WIT in experienced surgeon to RALPN. Read More

J Endourol 2022 Jun 14. Epub 2022 Jun 14.

Yonsei University Health System, Urology, Urological Science Institute, 134 Shinchon-dong Seodaemun-gu, Seoul, Korea (the Republic of), 120-752;

Purpose: To compare surgical outcomes between robot-assisted laparoendoscopic single-site surgery using the da Vinci Si or Xi system and the da Vinci SP system for partial nephrectomy.

Material And Methods: From 2008 to 2020, 66 partial nephrectomies were performed using a single-site robotic approach: 44 used the da Vinci Xi or Si system (R-LESS group) and 22 used the da Vinci SP system (SP group). After 1:1 propensity score-matching, surgical outcomes were compared between groups Results: Median patient age was 51. Read More

Int J Urol 2022 Jun 13. Epub 2022 Jun 13.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Front Oncol 2022 26;12:732714. Epub 2022 May 26.

Department of Urology, West China Fourth Hospital of Sichuan University, Chengdu, China.

Background: Minimally invasive partial nephrectomy (MIPN) and focal therapy (FT) are popular trends for small renal masses (SRMs). However, there is currently no systematic comparison between MIPN and FT of SRMs. Therefore, we systematically study the perioperative, renal functional, and oncologic outcomes of MIPN and FT in SRMs. Read More

Asian J Surg 2022 Jun 9. Epub 2022 Jun 9.

Department of Urology, Ewha Womans University Seoul Hospital, Seoul, South Korea.

Objective: To describe surgical technique for single port robotic surgery using the da Vinci SP system and report the perioperative outcomes.

Patients And Methods: Between Jan 2019 and Jan 2021, single-port robotic urologic surgeries were performed in 120 patients by a single surgeon. Clinicopathologic data and perioperative outcomes were collected. Read More

Urology 2022 Jun 9. Epub 2022 Jun 9.

Section of Urologic Oncology, Rutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ. Electronic address:

Objectives: To determine the morbidity, mortality, and costs associated with having concurrent venous thromboembolism (VTE) at the time of surgical resection of a renal mass.

Patients And Methods: We identified 108,430 patients undergoing elective partial or radical nephrectomy for a renal mass from 2013 to 2017 using the Premier Healthcare database. The association of VTE with 90-day complication rates, mortality, ICU admission, readmission, and direct hospital costs (2019 US dollars) was determined with multivariable logistic regression and quantile regression models, respectively. Read More

Cancer Genet 2022 Jun 5;266-267:28-32. Epub 2022 Jun 5.

Department of Urology, Kyoto University Hospital, 54 Shogoinkawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Birt-Hogg-Dubé syndrome is an autosomal dominant disease caused by germline mutations in the folliculin gene (FLCN), characterized by skin fibrofolliculomas, pulmonary cysts, and multiple renal tumors. We report the case of a 51-year-old woman with multiple bilateral renal tumors resected by bilateral open partial nephrectomy. Following pathological diagnosis of hybrid oncocytic/chromophobe tumors, targeted next-generation sequencing of FLCN of the patient's blood revealed a novel missense mutation (c. Read More

Can J Urol 2022 Jun;29(3):11142-11149

Division of Urology, Department of Surgery, Saint Louis University, St Louis, Missouri, USA.

Introduction: We aimed to examine stage-specific oncologic outcomes for young versus conventional-age patients with localized disease in a modern cohort.

Materials And Methods: The Surveillance, Epidemiology and End Results database was queried for patients with T1-T2N0M0 kidney cancer from 1975-2016, including clear cell, papillary, and chromophobe renal cell carcinoma. Patients were stratified into ≤ 40 years-old or > 40 years-old cohorts and underwent definitive treatment via percutaneous ablation, partial nephrectomy, or radical nephrectomy. Read More

Ther Apher Dial 2022 Jun 11. Epub 2022 Jun 11.

Department of Urology, Japanese Red Cross Medical Center, Tokyo, Japan.

JAMA Netw Open 2022 Jun 1;5(6):e2216379. Epub 2022 Jun 1.

Tom Baker Cancer Centre, Department of Medical Oncology, University of Calgary, Calgary, Canada.

Importance: The association between treatment with first-line immuno-oncology (IO) combination therapies and physician-assessed objective imaging response among patients with metastatic renal cell carcinoma (mRCC) remains uncharacterized.

Objective: To compare the likelihood of objective imaging response (ie, complete or partial response) to first-line IO combination ipilimumab-nivolumab (IOIO) therapy vs approved IO with vascular endothelial growth factor inhibitor (IOVE) combination therapies among patients with mRCC.

Design, Setting, And Participants: This multicenter international cohort study was nested in routine clinical practice. Read More

J Urol 2022 Jun 10:101097JU0000000000002812. Epub 2022 Jun 10.

Pennsylvania Presbyterian Medical Center, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Active surveillance (AS) with the possibility of delayed intervention (DI) is emerging as a safe alternative to immediate intervention for many patients with small renal masses (SRMs). However, limited comparative data exist to inform the most appropriate management strategy for SRMs.

Methods: Decision analytic Markov modeling was performed to estimate the health outcomes and costs of four management strategies for 65-year-old patients with an incidental SRM: AS (with possible DI), immediate partial nephrectomy (PN), radical nephrectomy (RN), and thermal ablation (TA). Read More

J Urol 2022 Jun 10:101097JU0000000000002798. Epub 2022 Jun 10.

Division of Urology, McMaster Institute of Urology, McMaster University, Hamilton, Ontario, Canada.

Purpose: Percutaneous ablation therapy (AT) and partial nephrectomy (PN) are successful management strategies for T1a renal cancer. Our objective was to compare AT to PN with respect to recurrence-free survival (RFS) and overall survival (OS).

Materials And Methods: Patients post PN or AT for cT1aN0M0 renal cancer from 2011 - 2021 were identified from the national Canadian Kidney Cancer Information System (CKCis). Read More

J Endourol 2022 Jun 7. Epub 2022 Jun 7.

Yale School of Medicine, 12228, Urology, New Haven, Connecticut, United States;

Objective To investigate if peri-tumor and/or intra-tumor vasculature is associated with high grade tumor histology for renal cell carcinoma. Methods A retrospective review at a tertiary care facility was performed of patients who underwent radical nephrectomy or partial nephrectomy for a renal tumor between January 2015 to December 2020. Data of tumor characteristics was collected from final pathology reports. Read More