48 results match your criteria Neoplastic Brachial Plexopathy

Neoplastic nerve lesions.

Neurol Sci 2022 May 23;43(5):3019-3038. Epub 2022 Feb 23.

Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA.

Though metastasis and malignant infiltration of the peripheral nervous system is relatively rare, physicians should have a familiarity with their presentations to allow for prompt diagnosis and initiation of treatment. This article will review the clinical presentations, diagnostic evaluation, and treatment of neoplastic involvement of the cranial nerves, nerve roots, peripheral nerves, and muscle. Due to the proximity of the neural structure traversing the skull base, metastasis to this region results in distinctive syndromes, most often associated with breast, lung, and prostate cancer. Read More

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Post-thoracotomy neuralgic amyotrophy in a patient with BAP1 tumor predisposition syndrome: Multimodality longitudinal follow-up.

Muscle Nerve 2021 09 9;64(3):E7-E9. Epub 2021 Jun 9.

EMG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

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September 2021

Oral Methadone for Patients With Neuropathic Pain Due to Neoplastic Brachial Plexopathy.

J Palliat Care 2022 Apr 11;37(2):77-82. Epub 2021 May 11.

Palliative Care Unit, Takarazuka Municipal Hospital, Takarazuka, Japan.

The brachial plexus nerves originate from the cervical (C5-C8) and first thoracic (T1) spinal nerves, and innervate muscles and skin of the chest, shoulder, arm and hand. Brachial plexus injuries can occur as a result of shoulder trauma and inflammation. Malignant tumors can also cause neoplastic brachial plexopathy (NBP), and refractory neuropathic pain is the most common symptom of NBP. Read More

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Pulsed Radiofrequency Ablation: An Alternative Treatment Modality for Radiation-Induced Brachial Plexopathy.

Pain Med 2021 03;22(3):749-753

Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Radiation therapy is used as a form of treatment for various neoplastic diseases. There are many potential adverse effects of this therapy, including radiation-induced neurotoxicity. Radiation-induced brachial plexopathy (RIBP) may occur due to the fibrosis of neural and perineural soft tissues, leading to ischemic damage of the axons and Schwann cells. Read More

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Brachial and lumbosacral plexopathies: A review.

Devon I Rubin

Clin Neurophysiol Pract 2020 13;5:173-193. Epub 2020 Aug 13.

Electromyography Laboratory, Mayo Clinic, Jacksonville, FL, USA.

Diseases of the brachial and lumbosacral plexus are uncommon and complex. The diagnosis of plexopathies is often challenging for the clinician, both in terms of localizing a patient's symptoms to the plexus as well as determining the etiology. The non-specific clinical features and similar presentations to other root, nerve, and non-neurologic disorders emphasize the importance of a high clinical index of suspicion for a plexopathy and comprehensive clinical evaluation. Read More

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Neurological and Dexterity Assessments in a Woman with Radiation-Induced Brachial Plexopathy After Breast Cancer.

Oncologist 2020 10 23;25(10):e1583-e1585. Epub 2020 Jun 23.

Physical Therapy Department, St. Paul's Hospital, Vancouver, BC, Canada.

The aim of this case report is to inform clinicians about radiation-induced brachial plexopathy, a rare complication that often presents well after treatment with inconsistent symptoms and manifestations. It is often a diagnosis of exclusion when a neoplastic or other cause cannot be identified. Electrodiagnostic testing is particularly useful. Read More

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October 2020

Malignant synovial sarcoma: An unpredictable cause of brachial plexopathy.

Clin Neurol Neurosurg 2020 06 2;193:105767. Epub 2020 Mar 2.

Department of Neurology, Institute of Human Behavior and Allied Sciences, New Delhi, India.

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Application of CUBE-STIR MRI and high-frequency ultrasound in contralateral cervical 7 nerve transfer surgery.

Br J Neurosurg 2019 Mar 12:1-6. Epub 2019 Mar 12.

a Department of Hand Surgery, Huashan Hospital, Shanghai Medical College , Fudan University , Shanghai , China.

Objective: The objective of the study was to investigate the feasibility of CUBE-SITR MRI and high-frequency ultrasound for the structural imaging of the brachial plexus to exclude neoplastic brachial plexopathy or structural variation and measure the lengths of anterior and posterior divisions of the C7 nerve, providing guidelines for surgeons before contralateral cervical 7 nerve transfer.

Methods: A total of 30 patients with CNS and 20 with brachial plexus injury were enrolled in this retrospective study. All patients underwent brachial plexus CUBE-STIR MRI and high-frequency ultrasound, and the lengths of the anterior and posterior divisions of C7 nerve were measured before surgery. Read More

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Horner's Syndrome as Initial Manifestation of Possible Brachial Plexopathy Neurolymphomatosis.

Front Neurol 2019 22;10. Epub 2019 Jan 22.

Department of Neurology, Ohio State University Wexner Medical Center, Columbus, OH, United States.

Horner's syndrome is an established clinical finding unique to neoplastic brachial plexopathy. We present the case of a patient who developed Horner's syndrome as the first manifestation of neurolymphomatosis (NL) of the brachial plexus that did not have the usually associated bulky adenopathy/Pancoast syndrome phenotype. We discuss the clinical utility of Horner's syndrome with regards to brachial plexopathy of indeterminate etiology, as well as the utility of other diagnostic modalities in NL. Read More

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January 2019

Current status of magnetic resonance neurography in evaluating patients with brachial plexopathy.

Neurol India 2019 Jan-Feb;67(Supplement):S118-S124

Department of Plastic Surgery, King George Medical University, Lucknow, Uttar Pradesh, India.

Magnetic resonance neurography (MRN) is recognized as the imaging modality of choice in the evaluation of patients with brachial plexopathy. It adds vital information to the results of the clinical evaluation and electrodiagnostic tests and facilitates patient management. Its indications include both trauma and non-traumatic forms of plexopathy such as inflammatory, neoplastic and compressive. Read More

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December 2019

Plexus and peripheral nerve metastasis.

Kelly G Gwathmey

Handb Clin Neurol 2018 ;149:257-279

Department of Neurology, University of Virginia, Charlottesville, VA, United States. Electronic address:

Cancer in the form of solid tumors, leukemia, and lymphoma can infiltrate and metastasize to the peripheral nervous system, including the cranial nerves, nerve roots, cervical, brachial and lumbosacral plexuses, and, rarely, the peripheral nerves. This review discusses the presentation, diagnostic evaluation, and treatment options for metastatic lesions to these components of the peripheral nervous system and is organized based on the anatomic distribution. As skull base metastases (also discussed in Chapter 14) result in cranial neuropathies, these will be covered in detail, as well as cancers that directly infiltrate the cranial nerves. Read More

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Neurolymphomatosis of the Brachial Plexus and its Branches: Case Series and Literature Review.

Can J Neurol Sci 2018 03 8;45(2):137-143. Epub 2018 Jan 8.

2Ottawa Hospital Research Institute,Ottawa,Ontario,Canada.

Background: Neurolymphomatosis is a process of neoplastic endoneurial invasion, most strongly associated with non-Hodgkin's lymphoma. It must be distinguished from paraneoplastic, metabolic, nutritional and treatment-related causes of neuropathy that are common in this patient population.

Methods: This brief case series illustrates the protean manifestations of neurolymphomatosis of the brachial plexus, ranging from focal distal mononeuropathy to multifocal brachial plexopathy, either as the index manifestation of lymphoma or as a complication of relapsing disease. Read More

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Idiopathic Brachial Neuritis in a Patient with Multiple Myeloma.

J Clin Diagn Res 2017 Jun 1;11(6):OD11-OD12. Epub 2017 Jun 1.

Department of Neurology, Sisli Hamidiye Etfal Education and Research Hospital, Istanbul, Turkey.

Idiopathic Brachial Neuritis (IBN), is a rare brachial plexopathy with an unknown aetiology. Multiple myeloma is a neoplastic plasma cell disease characterised by bone lesions. In this article, we present the case of a 59-year-old male patient with IBN associated with multiple myeloma, who was admitted to our clinic with right shoulder pain and right arm weakness. Read More

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Clinical impact of magnetic resonance neurography in patients with brachial plexus neuropathies.

Br J Radiol 2016 Nov 19;89(1067):20160503. Epub 2016 Sep 19.

1 Musculoskeletal Imaging Division, Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA.

Objective: To study the impact of brachial plexus MR neurography (MRN) in the diagnostic thinking and therapeutic management of patients with suspected plexopathy.

Methods: MRN examinations of adult brachial plexuses over a period of 18 months were reviewed. Relevant data collection included-patient demographics, clinical history, pre-imaging diagnostic impression, pre-imaging treatment plan, post-imaging diagnosis, post-imaging treatment plan, surgical notes and electrodiagnostic (ED) results. Read More

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November 2016

Pediatric Nerve Biopsy Diagnostic and Treatment Utility in Tertiary Care Referral.

Pediatr Neurol 2016 05 5;58:3-11. Epub 2016 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Department of Neurology, Mayo Clinic, Rochester, Minnesota; Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Pediatric neuropathies are both unique and similar to their adult counterparts, with genetic varieties thought to be more common. The objective of this work was to assess the utility of nerve biopsy in children at a tertiary referral center in light of availability of current genetic testing.

Methods: We retrospectively reviewed the clinical, nerve biopsy, and genetic testing findings of 316 pediatric (age ≤18 years) patients. Read More

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Clinical Utility of (18)F-FDG PET/CT in brachial plexopathy secondary to metastatic breast cancer.

Indian J Nucl Med 2016 Apr-Jun;31(2):123-7

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India.

Role of fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) in breast cancer is rapidly evolving. Brachial plexopathy is a rare clinical entity in follow-up of operated breast cancer patients, who presents with disease recurrence in the axilla. Conventionally, magnetic resonance imaging is the imaging modality of choice for diagnostic evaluation in these cases and only few case reports/short studies have explored the utility of PET/CT in this clinical indication. Read More

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Brachial Plexus Block for Cancer-Related Pain: A Case Series.

Pain Physician 2015 Sep-Oct;18(5):E917-24

Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA.

Neoplastic brachial plexopathy (NBP) is caused by a cancerous infiltration into the brachial plexus, presenting often as severe pain in the affected upper extremity. Such pain can be resistant to medical treatment. Invasive interventions such as brachial plexus neurolysis with phenol or cordotomy may result in severe complications including permanent neurological damage and death. Read More

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[Brachial plexopathy after breast cancer].

Ugeskr Laeger 2014 Dec;176(25A)

Neurologisk Afdeling F, Aarhus Universitetshospital, Nørrebrogade 44, 8000 Aarhus C.

Neoplastic plexopathy is an unusual, but known cause of neuropathy. This is a case report of a patient, who developed brachial plexopathy years after completing treatment for breast cancer. The patient presented with pain in one arm and, subsequently, developed sensory deficits and muscle atrophy, resulting in severely impaired hand function. Read More

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December 2014

Brachial plexus compression: a rare sequelae of malignant papillary thyroid carcinoma.

Int J Clin Exp Med 2013 1;6(7):606-8. Epub 2013 Aug 1.

Department of Otolaryngology, Head and Neck Surgery, Tulane University School of Medicine New Orleans, LA, USA.

Invasive papillary thyroid carcinoma (PTC) can rarely invade adjacent vital structures. There has been one report on secondary brachial plexopathy associated with locally invasive PTC. Here we report a patient with a large locally invasive PTC associated with secondary neoplastic brachial plexopathy. Read More

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Pulsed radiofrequency treatment within brachial plexus for the management of intractable neoplastic plexopathic pain.

J Anesth 2013 Apr 16;27(2):298-301. Epub 2012 Oct 16.

Multidisciplinary Pain Center, School of Medicine, Aichi Medical University, 21 Karimata, Nagakutecho, Aichigun, Aichi 480-1195, Japan.

We report on the use of pulsed radiofrequency (RF) within the plexus for the management of intractable pain in three patients with metastatic or invasive plexopathy. The patients were a 38-year-old woman with a history of breast cancer 6 years earlier whose computed tomography (CT) scans revealed a mass lesion at the infraclavicular part of the right brachial plexus, a 68-year-old man diagnosed with advanced lung cancer whose CT scans revealed a bone metastasis in the right humerus invading the axillary region of the right brachial plexus, and a 67-year-old woman diagnosed with advanced lung cancer whose CT scans revealed a bone metastasis in the left humerus invading the axillary region of the left brachial plexus. Ultrasound-guided pulsed RF was performed within the interscalene brachial plexus. Read More

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Clinical, Electrophysiological Findings in Adult Patients with Non-traumatic Plexopathies.

Ann Rehabil Med 2011 Dec 30;35(6):807-15. Epub 2011 Dec 30.

Department of Physical Medicine and Rehabilitation, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.

Objective: To ascertain the etiology of non-traumatic plexopathy and clarify the clinical, electrophysiological characteristics according to its etiology.

Method: We performed a retrospective analysis of 63 non-traumatic plexopathy patients that had been diagnosed by nerve conduction studies (NCS) and needle electromyography (EMG). Clinical, electrophysiological, imaging findings were obtained from medical records. Read More

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December 2011

Electrodiagnostic findings heralding neoplastic brachial plexopathy.

PM R 2012 Mar;4(3):238-40

Division of Neuromuscular Disorders, Department of Neurology, The Ohio State University, 395 W 12th Ave, Columbus, OH 43210, USA.

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Neoplastic brachial plexopathy detected by ultrasonography in a patient with chronic cervicobrachialgia.

J Rehabil Med 2012 Feb;44(2):181-3

Department of Physical Medicine and Rehabilitation, Turkish Armed Forces Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey.

Objective: We report here a case of neoplastic brachial plexopathy detected by musculoskeletal ultrasonography in a patient with chronic cervicobrachialgia.

Methods/results: A 71-year-old man presented at Gülhane Military Medical Academy, Turkish Armed Forces Rehabilitation Center, Ankara, Turkey with a one-year history of cervicobrachial pain radiating to the left arm and numbness in the medial aspect of the left arm and hand. He could not tolerate magnetic resonance imaging because his pain was exacerbated by cervical extension. Read More

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February 2012

Neuromuscular complications.

Handb Clin Neurol 2012 ;105:781-803

Kaiser Franz Josef Hospital, Vienna, Austria.

Although direct neoplastic involvement of muscle tis-sue is surprisingly rare, considering the large amount of body mass that is represented by muscle tissue, the most important and unresolved muscle effect is muscle cachexia.Other associations, such as inflammatory, paraneo-plastic, toxic, and several extremely rare associations,have been described. Drug-induced toxicity and radiation recall syndrome need to be taken into consideration when muscle symptoms appear in patients with cancer. Read More

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Frequency and outcome of neoplastic brachial plexopathy: single institution experience.

Ir Med J 2011 Mar;104(3):76-8

Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7.

Symptomatic neoplastic brachial plexopathy (NBP) is estimated to occur in about 0.4% of all patients with cancer. The aim of this review was to determine the incidence of NBP occurring in patients referred for magnetic resonance imaging (MRI). Read More

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Brachial plexus and nerves about the shoulder.

Semin Musculoskelet Radiol 2010 Nov 11;14(5):523-46. Epub 2010 Nov 11.

Cattedra di Radiologia-DISC, Università di Genova, Largo Rosanna Benzi 8, Genoa, Italy.

Ultrasound (US) and MR imaging have been shown able to detect in-depth features of brachial plexus anatomy and to localize pathological lesions in disorders where electrophysiology and physical findings are nonspecific or nonlocalizing. High-end gradient technology, phased array coils, and selection of an appropriate protocol of pulse sequences are the main requirements to evaluate the brachial plexus nerves with MR imaging and to distinguish between intrinsic and extrinsic pathological changes. A careful scanning technique based on anatomical landmarks is required to image the brachial plexus nerves with US. Read More

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November 2010

Neurologic manifestations of neoplastic and radiation-induced plexopathies.

Kurt A Jaeckle

Semin Neurol 2010 Jul 24;30(3):254-62. Epub 2010 Jun 24.

Department of Neurology and Oncology, Mayo Clinic Florida, Jacksonville, Florida 32224, USA.

Metastatic plexopathy is often a disabling accompaniment of advanced systemic cancer, and may involve any of the peripheral nerve plexuses. Brachial plexopathy most commonly occurs in carcinoma of the breast and lung; lumbosacral plexopathy is most common with colorectal and gynecologic tumors, sarcomas, and lymphomas. Neoplastic plexopathy is often characterized initially by severe, unrelenting pain followed by development of weakness and focal sensory disturbances. Read More

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Diagnostic value and surgical implications of the magnetic resonance imaging in the management of adult patients with brachial plexus pathologies.

Surg Radiol Anat 2008 Mar 20;30(2):91-101. Epub 2007 Dec 20.

Department of Neuroradiology, IRCCS San Raffaele, Università Vita e Salute, Via Olgettina 60, 20132, Milan, Italy.

The imaging of the brachial plexus (BP) cannot easily be achieved because of the extension of the region to be studied, the different tissue compositions of the adjacent anatomic structures and the necessity to work with thin tissue slices. Here is a description of the brachial plexus MRI (bpMRI) protocol that we use for the pre-operative evaluation of patients affected by the following brachial plexus (BP) pathologies: neoplastic, post-traumatic, inflammatory. The surgical implications are discussed. Read More

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