270,259 results match your criteria Neoplastic Brachial Plexopathy


Posterior Extensive Circumferential Decompressive Reconstructive Technique in surgical treatment of Upper Thoracic Spine Compressive Lesions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Orthopedic Surgery and Traumatology and Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt; Minia University Spine Unit (MUSU), Faculty of Medicine, Minia University. Minia University Hospital, Mohammed Badway str., 61111, El-Minia, Egypt. Electronic address:

Background Data: Complexity in ventral surgical exposure, presence of scapula and large para-scapular musculature during posterior surgery are the main obstacles in operative treatment of Upper Thoracic Spine Compressive Lesions (UTSCL) like trauma, tuberculosis and neoplasm. Recently, the advantages of combined ventro-dorsal surgery could be successfully gained using 1-stage posterior salvage technique with enough accessibility to all three spinal columns.

Purpose: Retrospective evaluation of 35 patients with UTSCL treated by Posterior Extensive Circumferential Decompressive Reconstructive (PECDR) procedure. Read More

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December 2018
1 Read

Design, synthesis and anti-tumor evaluation of novel steroidal glycoconjugate with furoxan derivatives.

Steroids 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address:

In this study, eighteen novel steroidal-furoxan derivatives with 3-glycosyl or 3-methoxy moiety (12a-c, 13a-c, 17a-c, 26a-c, 27a-c and 28a-c) were synthesized and their anti-proliferative activity was evaluated against eight drug-sensitive and three drug-resistant cancer cell lines HeLa, A2780, LNCaP, PC-3, MDA-MB-231, MCF-7, SW480, A549, MCF-7/ADR, A2780/CDDP and A2780/T. Most of them displayed significant anti-cancer potency in vitro with IC values at the nanomole level. Among them, 3-methoxy steroidal-furoxan hybrids expressed much better activity than that of 3-glycosyl substitute ones, while estrane and 5α-H-androstane scaffold were slightly more favorable to the improvement of anti-proliferative activity. Read More

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December 2018
3 Reads

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018

A Rare Diagnosis After the Fall of a 96-Year-Old Woman: Doege-Potter Syndrome.

Curr Aging Sci 2018 Dec 5. Epub 2018 Dec 5.

Acute Geriatrics Unit, Monza (MB). Italy.

Introduction: Doege-Potter syndrome (DPS) is a rare but life-threatening paraneoplastic syndrome, characterized by non-islet cell tumor-induced hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT), which secretes an incompletely processed form of insulin-like growth factor 2 (IGF-2).

Results: A 96-year-old woman was admitted with head trauma due to an accidental fall. During her hospital stay she experienced frequent hypoglycemic episodes. Read More

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December 2018

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

Circulating tumor DNA, circulating tumor cells and tumor-related exosomes may offer new opportunities to provide insights into the biological and clinical characteristics of a neoplastic disease. They represent alternative routes for diagnostic and prognostic purposes, and for predicting and longitudinally monitoring response to treatment and disease progression. Hence, circulating biomarkers represent promising noninvasive tools in the scenario of pancreatic cancer, where neither molecular nor clinical predictors of treatment benefit have been identified yet. Read More

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December 2018

Phytol ameliorated benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice via inhibition of oxidative stress and apoptosis.

Environ Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biotechnology, Alagappa University (Science Campus), Karaikudi, Tamil Nadu, India.

In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated group and also in animals post-treated with low concentration (50 mg/kg) of phytol. Read More

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December 2018
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Incidence of fatigue and low-dose corticosteroid use in prostate cancer patients receiving systemic treatment: a meta-analysis of randomized controlled trials.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

Background: Cancer-related fatigue (CRF) is a complex condition that is reported in > 50% of cancer patients. In men with castration-resistant prostate cancer (CRPC), CRF was reported in 12-21% of patients. Approved systemic therapy against CRPC is commonly administered in combination with androgen-deprivation treatment (ADT) and, in some cases, with daily, low-dose corticosteroids. Read More

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December 2018

Preliminary Results of Bone Regeneration in Oromaxillomandibular Surgery Using Synthetic Granular Graft.

Biomed Res Int 2018 5;2018:8503427. Epub 2018 Nov 5.

Unit of Maxillo-Facial Surgery, University of Rome "Sapienza", Azienda Ospedaliera Universitaria "Sant'Andrea", Rome, Italy.

Traumatic, neoplastic, inflammatory, or infective dental removal promotes a gradual resorption process of bone which leads to a "nonuse" atrophy of the alveolar ridges. Many techniques allows restoring an appropriate bone thickness, but nowadays the attention is focused on the use of natural or synthetic grafts. Numerous studies have been conducted to develop and test new synthetic materials. Read More

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November 2018

Chondrosarcoma: biology, genetics, and epigenetics.

Authors:
Warren A Chow

F1000Res 2018 20;7. Epub 2018 Nov 20.

Department of Medical Oncology & Therapeutics Research, City of Hope, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.

Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone malignancy. The vast majority of chondrosarcomas are conventional chondrosarcomas, and most conventional chondrosarcomas are low- to intermediate-grade tumors (grade 1 or 2) which have indolent clinical behavior and low metastatic potential. Read More

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November 2018
2 Reads

Blood and skin-derived Sezary cells: differences in proliferation-index, activation of PI3K/AKT/mTORC1 pathway and its prognostic relevance.

Leukemia 2018 Dec 5. Epub 2018 Dec 5.

Istituto Dermopatico dell'Immacolata, IDI-IRCCS, 00167, Rome, Italy.

Sézary syndrome (SS) is a rare and aggressive variant of Cutaneous T-Cell Lymphoma characterized by neoplastic distribution mainly involving blood, skin, and lymph-node. Although a role of the skin microenvironment in SS pathogenesis has long been hypothesized, its function in vivo is poorly characterized. To deepen this aspect, here we compared skin to blood-derived SS cells concurrently obtained from SS patients highlighting a greater proliferation-index and a PI3K/AKT/mTORC1 pathway activation level, particularly of mTOR protein, in skin-derived-SS cells. Read More

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December 2018
1 Read

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.

Sci Rep 2018 Dec 5;8(1):17654. Epub 2018 Dec 5.

Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Angiogenesis is crucial for tissue development and homeostasis; however, excessive angiogenesis can lead to diseases, including arthritis and cancer metastasis. Some antiangiogenic drugs are available, but side effects remain problematic. Thus, alternative angiogenesis inhibition strategies are needed. Read More

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December 2018

Fibroinflammatory Liver Injuries as Preneoplastic Condition in Cholangiopathies.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

School of Medicine and Surgery, University of Milan-Bicocca, Via Cadore 48, 20900 Monza, Italy.

The cholangipathies are a class of liver diseases that specifically affects the biliary tree. These pathologies may have different etiologies (genetic, autoimmune, viral, or toxic) but all of them are characterized by a stark inflammatory infiltrate, increasing overtime, accompanied by an excess of periportal fibrosis. The cellular types that mount the regenerative/reparative hepatic response to the damage belong to different lineages, including cholagiocytes, mesenchymal and inflammatory cells, which dynamically interact with each other, exchanging different signals acting in autocrine and paracrine fashion. Read More

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December 2018
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Utility of Cement Augmentation via Percutaneous Fenestrated Pedicle Screws for Stabilization of Cancer Related Spinal Instability.

Oper Neurosurg (Hagerstown) 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Cancer patients experience pathological fractures and the typical poor bone quality frequently complicates stabilization. Methods for overcoming screw failure include utilization of fenestrated screws that permit the injection of bone cement into the vertebral body to augment fixation.

Objective: To evaluate the safety and efficacy of cement augmentation via fenestrated screws. Read More

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December 2018

Impact of stainless-steel welding fumes on proteins and non-coding RNAs regulating DNA damage response in the respiratory tract of Sprague-Dawley rats.

J Toxicol Environ Health A 2018 Dec 3:1-15. Epub 2018 Dec 3.

a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , TN , India.

Substantial evidence has established the negative impact of inhalation exposure to welding fumes on respiratory functions. The aim of the present study was to investigate the effect of welding fume inhalation on expression of molecules that function as sensors, transducers and effectors of DNA damage response (DDR) in the respiratory tract of male Sprague-Dawley rats. Animals were exposed to 50 mg/m stainless steel welding fumes for 1 h/d for 4, 8, and 12 weeks, respectively. Read More

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December 2018

[Imaging characteristics of gastrointestinal neoplastic acute abdomen].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1223-1229

Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China.

Both malignant tumors derived from gastrointestinal tract and metastasis from peritoneal spread, hematogenous dissemination and lymph node can lead to acute abdomen. Such acute abdomen patients have poor prognosis, high mortality, and complex clinical manifestations. It is difficult to make a correct diagnosis in clinical practice. Read More

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November 2018

Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability.

Transl Gastroenterol Hepatol 2018 31;3:84. Epub 2018 Oct 31.

Hepatology Program, CIMA, University of Navarra, Pamplona, Spain.

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. HCCs are molecularly heterogeneous tumors, and this complexity is to a great extent responsible for their poor response to conventional and targeted therapies. In this review we summarize recent evidence indicating that imbalanced expression of mRNA splicing factors can be a relevant source for this heterogeneity. Read More

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October 2018

Application of diffusion tensor imaging in brain lesions: A comparative study of neoplastic and non-neoplastic brain lesions.

Neurol India 2018 Nov-Dec;66(6):1667-1671

Department of Biostatistics and Health Informatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Purpose: To evaluate the role of diffusion tensor imaging (DTI) in the differentiation of neoplastic and non-neoplastic brain lesions, on the basis of DTI parameters, fractional anisotropy (FA) and mean diffusivity (MD) from the lesion (L) and the perilesional edema (PE).

Material And Methods: Patients with newly diagnosed 25 neoplastic [10 high grade gliomas (HGG), 11 metastases, 4 low grade glioma (LGG)] and 25 non-neoplastic [13 tuberculomas and 12 neurocysticercosis (NCC)] brain lesions underwent an MRI, including the DTI sequences. Fractional anisotropy from the lesion (FAL) and mean diffusivity from the lesion (MDL), as well as fractional anisotropy from the perilesional edema (FAPE), and mean diffusivity from the perilesional edema (MDPE) were calculated and quantified using region of interest (ROI) based assessment on DTI derived FA and MD parametric maps. Read More

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December 2018

Exosomal MicroRNA Expression Profiling in Patients with Lung Adenocarcinoma-associated Malignant Pleural Effusion.

Anticancer Res 2018 Dec;38(12):6707-6714

The Department of Respiratory Medicine, The University of Tokyo Hospital, Tokyo, Japan.

Background/aim: Cytological analysis for diagnosing malignant pleural effusion associated with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic biomarkers are needed. The aim of this study was to evaluate the profile of four microRNAs (miRNAs) in exosomes in Ad-MPE and benign (non-neoplastic) pleural effusion (BPE).

Materials And Methods: A total of 56 pleural effusion samples from patients with lung adenocarcinoma and benign diseases were collected. Read More

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December 2018

Embryonal Origin of Metanephric Adenoma and its Differential Diagnosis.

Anticancer Res 2018 Dec;38(12):6663-6667

Department of Urology, Medical School, University of Pecs, Pecs, Hungary

Background/aim: The association of Wilms' tumor (WT), papillary renal cell tumor (PRCT) and mucinous tubular and spindle cell carcinoma (MTSCC) with embryonal rests has already been documented, but the cellular origin of metanephric adenoma (MA) is not yet known. The aim of this study was to understand their developmental evolution and find diagnostic markers.

Materials And Methods: CD57, KRT7, AMACR, SCEL, WT1 and CDH17 expression was analysed by immunohistochemistry in the four types of tumors and the associated pre-neoplastic lesions. Read More

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December 2018

Effect of Combined Epigenetic Treatments and Ectopic NIS Expression on Undifferentiated Thyroid Cancer Cells.

Anticancer Res 2018 Dec;38(12):6653-6662

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Background: Poorly differentiated (PDTC) and anaplastic thyroid (ATC) cancer cells are characterized by the acquisition of epigenetic abnormalities, leading to the silencing of both the sodium iodide co-transporter and the Coxsackie adenovirus receptor. As aberrant histone acetylation and DNA methylation represent epigenetic mechanisms involved in neoplastic transformation, our study investigated the anticancer properties of epigenetic modifiers in thyroid carcinoma.

Materials And Methods: The cytotoxicity and gene expression modulation of histone deacetylase and DNA methyltransferase inhibitors were evaluated in both PDTC and ATC. Read More

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December 2018
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The new tool "" in advanced systemic mastocytosis.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):127-136

Divisions of Hematology and.

Mastocytosis is a rare disease characterized by KIT-driven expansion and accumulation of neoplastic mast cells in various tissues. Although mediator symptoms related to mast cell activation can impose a symptom burden in cutaneous disease and across the spectrum of systemic mastocytosis subtypes, the presence of an associated hematologic neoplasm and/or organ damage denotes advanced disease and the potential for increased morbidity and mortality. In addition to the revised 2016 World Health Organization classification of mastocytosis, a new diagnostic and treatment toolkit, tethered to enhanced molecular characterization and monitoring, is poised to transform the management of patients with advanced systemic mastocytosis (advSM). Read More

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November 2018

Characteristics of hyperfibrinolysis in dogs and cats demonstrated by rotational thromboelastometry (ROTEM).

Vet J 2018 Dec 5;242:67-73. Epub 2018 Nov 5.

Section of Anaesthesiology, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zurich, Winterthurerstr. 258c, CH-8057 Zürich, Switzerland.

Hyperfibrinolysis (HFL) is a pathophysiological mechanism that has not been described in dogs or cats extensively. The aim of this study was to describe rotational thromboelastometry (ROTEM) parameters and underlying diagnosis in dogs and cats with HFL and evaluate association with bleeding diathesis. The ROTEM database was retrospectively searched for EXTEM (ROTEM activated with proprietary tissue factor) tracings with maximum lysis at 60min ≥15%. Read More

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December 2018

Utility of flow cytometry in canine primary cutaneous and matched nodal mast cell tumor.

Vet J 2018 Dec 12;242:15-23. Epub 2018 Oct 12.

Department of Veterinary Sciences, University of Turin, Largo P. Braccini 2, 10095 Grugliasco, Turin, Italy. Electronic address:

Mast cell tumors (MCT) are among the most frequent tumors in dogs, but studies regarding canine mast cell immunophenotype are lacking. The aim of this study was to assess the feasibility of flow cytometric analysis of MCTs, to describe canine MCTs immunophenotype(s), and to evaluate the ability of flow cytometry to detect mast cells in lymph node aspirates. Thirty-four primary canine MCTs and 12 draining lymph nodes were evaluated regarding the expression of CD117, IgE, CD11b, CD18, CD44, CD34, CD25 and CD45. Read More

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December 2018

Evidences against vesicle-dependent trafficking and involvement of extracellular proteasomes into cell-to-cell communications.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Institute of Cytology, Russian Academy of Sciences, St-Petersburg, 194064, Russia. Electronic address:

The ubiquitin proteasome system is involved in the regulation of most basic intracellular processes, and deregulation of this system can results in certain kinds of human diseases. Proteolytic core this system, the 20S proteasome, has been found in physiological fluids of both healthy humans and patients suffering from a variety of inflammatory, autoimmune, and neoplastic diseases. The concentration of these extracellular proteasomes has been found to correlate with the diseased state, being of a prognostic significance. Read More

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November 2018

Lower number of 5-hydroxymethylcytosine-expressing cells in plasma cell myeloma than in reactive plasma cell hyperplasia: a useful immunohistochemical approach for identification of neoplastic plasma cells.

Pathology 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address:

Plasma cell myeloma (PCM) is a haematological malignancy defined by aberrant proliferation of plasma cells in the bone marrow. For the diagnosis of PCM, immunostaining of light chains or surface marker analyses by flow cytometry is needed but sometimes difficult. Aberrant methylation at the carbon-5 position of cytosine results in 5-methylcytosine (5-mC), which is a well-known epigenetic hallmark of cancer in mammals. Read More

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November 2018

Primary Meningeal Rhabdomyosarcoma of the Spinal Cord of a Young Dog with Neuromelanocytosis and Multiple Cutaneous Neurofibromas.

J Comp Pathol 2018 Nov 25;165:57-61. Epub 2018 Oct 25.

Frederick National Laboratory for Cancer Research, National Cancer Institute, Fort Detrick, Frederick, Maryland, USA.

A 7-week-old male black Labrador retriever puppy was presented for post-mortem examination following progressive hindlimb paralysis and multiple masses within the skin. A highly compressive and infiltrative intradural mass was found within the T9-T11 spinal cord. Microscopical and immunohistochemical analysis revealed features compatible with spindle cell rhabdomyosarcoma (RMS). Read More

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November 2018

Association between Degree of Anaplasia and Degree of Inflammation with the Expression of COX-2 in Feline Injection Site Sarcomas.

J Comp Pathol 2018 Nov 24;165:45-51. Epub 2018 Oct 24.

Image Analysis Laboratory, School of Veterinary Sciences, National University of La Plata, La Plata, Argentina; Laboratory of Descriptive, Experimental and Comparative Histology and Embryology, School of Veterinary Sciences, National University of La Plata, La Plata, Argentina; National Research Council of Science and Technology, CABA, Buenos Aires, Argentina.

Feline injection site sarcomas (FISSs) are mesenchymal neoplasms that develop at the sites of delivery of vaccines or other injectable products. Vaccine adjuvants can trigger an intense and persistent inflammatory response that may lead to neoplastic transformation. The proinflammatory role of cyclo-oxygenase (COX)-2 is well known and its overexpression has prognostic value in multiple neoplastic processes. Read More

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November 2018

Malignant Cutaneous Peripheral Nerve Sheath Tumour with Rhabdomyosarcomatous Differentiation (Triton Tumour) in a Domestic Cat.

J Comp Pathol 2018 Nov 18;165:1-5. Epub 2018 Oct 18.

Department of Pathobiology and Population Sciences, The Royal Veterinary College, Hatfield, Hertfordshire, UK.

Divergent differentiation is encountered frequently within human malignant peripheral nerve sheath tumours (MPNSTs). The new component is often a rhabdomyosarcoma, but in animals this specific form of divergent differentiation within MPNSTs has only been reported once (in a dog). Incisional wedge biopsy of a locally extensive, ventral abdominal wall mass, which extended from the dermis to the subcutis, from a 12-year-old female domestic shorthaired cat, was performed. Read More

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November 2018
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Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2018 Nov 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

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November 2018

Insulinoma-associated protein 1 immunostaining on cytology specimens: an institutional experience.

Hum Pathol 2018 Nov 28. Epub 2018 Nov 28.

Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, USA.

Neuroendocrine tumors (NET) are epithelial neoplasms with prominent neuroendocrine differentiation. Cytologic examination and utilization of immunohistochemical (IHC) markers are important diagnostic tools for the evaluation of these tumors. Herein we report our experience with the application of INSM1 in cytology samples. Read More

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November 2018

Integrated Analysis of Mouse and Human Gastric Neoplasms Identifies Conserved microRNA Networks in Gastric Carcinogenesis.

Gastroenterology 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL, United States; Department of Veterans Affairs, Miami Healthcare System, Miami, FL, United States; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, United States.

Background & Aims: microRNAs (miRNAs) are small non-coding RNAs that bind to 3'UTR regions of mRNAs to promote their degradation or block their translation. Mice with disruption of the trefoil factor 1 gene (Tff1) develop gastric neoplasms. We studied these mice to identify conserved miRNA networks involved in gastric carcinogenesis. Read More

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November 2018

Lhermitte-Duclos Disease with Cervical Arteriovenous Fistula.

J Neurol Surg A Cent Eur Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Division of Neurosurgery, Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

Lhermitte-Duclos disease is a rare condition with less than 250 cases reported in the literature. It was considered a neoplastic or hamartomatous growth in the cerebellum. It commonly presents with symptoms of high intracranial pressure or obstructive hydrocephalus. Read More

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December 2018
1 Read

The Therapeutic Potential of Cannabinoids in Dermatology

Skin Therapy Lett 2018 11;23(6):1-5

Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, USA

Cannabinoids have demonstrated utility in the management of cancer, obesity, and neurologic disease. More recently, their immunosuppressive and anti-inflammatory properties have been identified for the treatment of several dermatologic conditions. This review thus assesses the therapeutic potential of phytocannabinoids, endoocannabinoids, and chemically synthetic cannabinoids in the management of cutaneous disease. Read More

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November 2018
2 Reads

Pressure Ulcer in Intensive Care Units: a case-control study.

Rev Bras Enferm 2018 Nov-Dec;71(6):3027-3034

Faculdade de Medicina de São José do Rio Preto. São José do Rio Preto, São Paulo, Brasil.

Objective: To evaluate the relationship between presence/absence of Pressure Ulcer, socio-demographic factors and hospitalization.

Method: Case-control study, performed through multiple logistic regression based on information from the adverse event reporting system and the hospital information system, between September/2014 and August/2015.

Results: Among the risk factors, after adjustment, age greater than or equal to 60 years, hospitalization due to infectious, parasitic and neoplastic diseases, periods of hospitalization longer than seven days and being hospitalized in ICU other than ICU covenant were highlighted. Read More

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February 2018
1 Read

Cognition, functionality and symptoms in patients under home palliative care.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):922-927

Physician from PUCSP, Master of Bioethics, Doctor of Medicine, Professor, Medicine School, PUCPR; Londrina (PR), Brasil.

Objective: Evaluating the degree of cognition, functionality, presence of symptoms and medications prescribed for patients under palliative home care.

Method: Descriptive, cross-sectional study where 55 patients under palliative home care were interviewed. Cognition was evaluated using the Mini-Mental state examination (MM), with patients being separated into two groups: with preserved cognitive ability (MM>24), or altered (MM <24). Read More

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October 2018
2 Reads

The Rare Neurocutaneous Disorders: Update on Clinical, Molecular, and Neuroimaging Features.

Top Magn Reson Imaging 2018 Dec;27(6):433-462

Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

Phakomatoses, also known as neurocutaneous disorders, comprise a vast number of entities that predominantly affect structures originated from the ectoderm such as the central nervous system and the skin, but also the mesoderm, particularly the vascular system. Extensive literature exists about the most common phakomatoses, namely neurofibromatosis, tuberous sclerosis, von Hippel-Lindau and Sturge-Weber syndrome. However, recent developments in the understanding of the molecular underpinnings of less common phakomatoses have sparked interest in these disorders. Read More

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December 2018
5 Reads

Tumor risk and surveillance for children with hereditary disorders affecting growth.

Curr Opin Endocrinol Diabetes Obes 2018 Dec 3. Epub 2018 Dec 3.

Division of Endocrinology, The Hospital for Sick Children.

Purpose Of Review: Hereditary disorders affecting growth (both overgrowth and growth retardation) are frequently associated with heightened risk of neoplastic disease. This review summarizes the tumor spectra associated with these conditions and identifies disease-specific screening approaches.

Recent Findings: An understanding of the molecular events underlying many of these growth disorders has evolved significantly over the past several years. Read More

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December 2018
1 Read

Divergent impact of actin isoforms on cell cycle regulation.

Cell Cycle 2018 Dec 5. Epub 2018 Dec 5.

b Blokhin Russian Cancer Research Center , Moscow , Russia.

We have shown that cytoplasmic actin isoforms play different roles in neoplastic cell transformation. β-Cytoplasmic actin acts as a tumor suppressor, affecting epithelial differentiation, cell growth, cell invasion and tumor growth of colon and lung carcinoma cells. In contrast, γ-cytoplasmic actin enhances malignant features of tumor cells whose actin network regulation is carried out via the γ-actin isoform. Read More

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December 2018
1 Read

Proinvasive extracellular matrix remodeling for tumor progression.

Arch Pharm Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Life Science, Research Institute for Natural Sciences, Hanyang University, Seoul, 04763, Republic of Korea.

Cancer is a systemic disease in which neoplastic cells interact with multiple types of non-neoplastic stromal cells as well as non-cellular components. The extracellular matrix (ECM) is a non-cellular component that is aberrantly regulated in many types of tumor microenvironments. Since the ECM generally maintains the tissue structure and provides mechanical forces in the tumor microenvironment, it has been simply assumed to act as a physical barrier for cancer metastasis and have a passive role in cancer progression. Read More

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December 2018
1 Read

A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer.

J Cell Commun Signal 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.

While 3D cellular models are useful to study biological processes, gel-embedded organoids have large variability. This paper describes high-yield production of large (~1 mm diameter), scaffold-free, highly-spherical organoids in a one drop-one organoid format using MCF10A cells, a non-tumorigenic breast cell line. These organoids display a hollow lumen and secondary acini, and express mammary gland-specific and progenitor markers, resembling normal human breast acini. Read More

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December 2018

Carnosic acid, Tangeretin, and Ginkgolide-B Anti-Neoplastic Cytotoxicity in Dual Combination with Dexamethasone-[anti-EGFR] in Pulmonary Adenocarcinoma (A549).

Anticancer Agents Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Basic Sciences, College of Veterinary Medicine at Wise Center, Mississippi State University, Mississippi State, Mississippi 39762. United States.

Background - Traditional chemotherapeutics of low-molecular weight diffuse passively across intact membrane structures of normal healthy cells found in tissues and organ systems in a non-specific unrestricted manner which largely accounts for the induction of most sequelae which restrict dosage, administration frequency, and duration of therapeutic intervention. Molecular strategies that offer enhanced levels of potency, greater efficacy and broader margins-of-safety include the discovery of alternative candidate therapeutics and development of methodologies capable of mediating properties of selective "targeted" delivery. Materials-and-Methods - The covalent immunopharmaceutical, dexamethasone-(C21-phosphoramidate)-[anti-EGFR] was synthesized utilizing organic chemistry reactions that comprised a multi-stage synthesis regimen. Read More

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December 2018
2 Reads

Robot-assisted resection of gastric duplication cysts in a child: a detailed case report.

Pediatr Med Chir 2018 Dec 4;40(2). Epub 2018 Dec 4.

Department of Pediatric Surgery, "Spirito Santo" Hospital, Pescara; "G. d'Annunzio" University, Chieti-Pescara.

Gastric duplication cysts (GDCs) represent 4-9% of alimentary tract duplications. Early diagnosis and surgical excision are essential to avoid morbidity or neoplastic degeneration. Roboticassisted excision of GDCs has never been described in childhood. Read More

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December 2018
5 Reads

Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice.

Am J Physiol Endocrinol Metab 2018 Dec 4. Epub 2018 Dec 4.

University of Ottawa, Canada.

Obesity-induced inflammation associated with increased risk for colorectal cancer (CRC). The role of diet and exercise in modulating increased CRC risk in obesity, and the potential role of altered hematopoiesis as a contributor to these effects remain unknown. The purpose of this study was to examine how weight loss induced during CRC induction with or without exercise alter CRC initiation and their relationship to altered hematopoiesis. Read More

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December 2018
2 Reads

High p-mTOR expression is associated with recurrence and shorter disease-free survival in atypical meningiomas.

Neuropathology 2018 Dec 3. Epub 2018 Dec 3.

Biomedical and Odontoiatric Sciences, and of Morphological and Functional Images, University of Messina, Messina, Italy.

Due to their widely variable clinical behavior, the post-surgical treatment of atypical meningiomas is controversial. Therefore, prognostic factors able to identify high-risk cases, which may benefit from adjuvant treatments, are warranted. Mammalian target of rapamycin (mTOR) belongs to the PI3K-AKT pathway. Read More

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December 2018

Primary Cutaneous vs Secondary Cutaneous Follicular Lymphomas: A Comparative Study Focused on BCL2, CD10 and t (14;18) Expression.

J Cutan Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Hospital del Mar. Parc de Salut Mar. IMIM, Barcelona, Spain.

Background: Primary cutaneous follicular center-cell lymphoma (PCFCL) is one of the most common types of cutaneous B-cell lymphoma. Differences in immunohistochemical expression of BCL2 and CD10 antigens along with the presence of t(14:18) translocation in neoplastic cells have been postulated as relevant clues in differentiating PCFCL from cutaneous lesions secondary to a systemic follicular lymphoma (SCFL). The aim of this study is to evaluate the significance and usefulness of these parameters in a large series of patients. Read More

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December 2018
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Solitary Lytic Bone Metastasis: A Rare Presentation of Small Lymphocytic Leukemia.

Case Rep Hematol 2018 30;2018:6154709. Epub 2018 Oct 30.

Department of Hematology/Oncology, Joan C. Edwards School of Medicine Marshall University, 1600 Medical Center Dr, Huntington, WV 25701, USA.

Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) is a hematologic malignancy characterized by an over accumulation of incompetent neoplastic lymphocytes. Bone metastasis in CLL/SLL is very rare. We report a case of a 76-year-old Caucasian female presented with an unresolving pulmonary infiltrate with mediastinal lymphadenopathy concerning for malignancy. Read More

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October 2018
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Gynaecological cancers and leptin: A focus on the endometrium and ovary.

Facts Views Vis Obgyn 2018 Mar;10(1):5-18

Ovarian Cancer Laboratory, Veterans Affairs Medical Center, Kansas City, MO 64128, United States.

Obesity has an influence on the risk and prognosis of different types of cancers of the female reproductive tract. In the uterus, a common site for neoplasms is the endometrium, the inner lining tissue. Generally, obesity has been documented to be involved in endometrioid carcinoma of the endometrium. Read More

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March 2018
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Prevalence and association of human papillomavirus, Epstein-Barr virus and Merkel Cell polyomavirus with neoplastic esophageal lesions in northern Iran.

Caspian J Intern Med 2018 ;9(4):353-360

Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Background: Studies concerning on esophageal squamous cell carcinoma (ESCC) etiological factors have been done for several decades, however, results reported from various investigations were not consistent. The present investigation aimed to explore the presence of 3 oncogenic viruses, human papilloma virus (HPV), Epstein-Barr virus (EBV) and Merkel cell polyomavirus (MCPyV) in the neoplastic and non- neoplastic esophageal lesions collected from Mazandaran, a high risk area of Iran.

Methods: In total, 168 esophageal specimens (100 with ESCC confirmed diagnosis and 68 without esophageal malignancy) were analyzed for HPV, EBV and MCPyV by Real Time PCR. Read More

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January 2018
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Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center.

Chin J Cancer Res 2018 Oct;30(5):546-552

Endoscopy Unit of Department of Gastroenterology, São Paulo Cancer Institute, University of São Paulo Medical School (ICESP-HCFMUSP), São Paulo 01246-000, Brazil.

Objective: Probe-based confocal laser endomicroscopy (pCLE) technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution images at the cellular and microvascular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric lesions.

Methods: Twenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Read More

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October 2018
2 Reads