5,441 results match your criteria Neoplasms of the Endocrine Pancreas


Current concepts in the diagnosis and management of neuroendocrine neoplasms of unknown primary.

Minerva Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Unit.

Neuroendocrine neoplams (NENs) of unknowm primary origin (UPO-NENs) are advanced neoplasms constituting 11%-22% of all NENs that by definition their primary tissue of origin has not been identified with standard diagnostic work-up. Delineating the primary site of origin of UPO-NENs has important implications for selecting the appropriate treatment and overall prognosis. The small bowel, followed by the lung and pancreas are the most prevalent primary sites of origin of UPO-NENs that are uncovered during an extensive and prolonged diagnostic work-up; however, a number of UPO-NENs may still remain occult even after prolonged follow-up. Read More

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https://www.minervamedica.it/index2.php?show=R07Y9999N00A190
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http://dx.doi.org/10.23736/S0391-1977.19.03012-8DOI Listing
April 2019
9 Reads

[Duodenum-preserving pancreatic head resection : A local parenchyma-sparing treatment of benign and premalignant tumors of the pancreatic head].

Chirurg 2019 Mar 21. Epub 2019 Mar 21.

Zentrum für onkologische, endokrinologische und minimalinvasive Chirurgie, Donau-Klinikum, Neu-Ulm, Deutschland.

Background: In contrast to the Kausch-Whipple procedure (pancreatoduodenectomy) duodenum-preserving pancreatic head resection (DPPHR) is associated with tissue sparing and maintenance of the pancreatic metabolic functions.

Aim: According to the results of controlled clinical trials the DPPHR procedure for benign pancreatic neoplasms is associated with low surgery-related complications and maintenance of glucose metabolism and exocrine pancreatic functions. This overview summarizes the clinical results of the use of DPPHR for chronic pancreatitis and benign tumors of the pancreatic head and the status of the clinical evidence of the results. Read More

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http://dx.doi.org/10.1007/s00104-019-0942-0DOI Listing
March 2019
1 Read

3 T MR perfusion of solid pancreatic lesions using dynamic contrast-enhanced DISCO sequence: Usefulness of qualitative and quantitative analyses in a pilot study.

Magn Reson Imaging 2019 Jun 14;59:105-113. Epub 2019 Mar 14.

Diagnostic and Interventional Radiology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. Electronic address:

Purpose: To assess the usefulness of qualitative and quantitative analyses of pancreatic focal diseases by using the dynamic contrast-enhanced Differential Subsampling with Cartesian Ordering (DISCO) sequence at 3 T MR device.

Materials And Methods: Ten patients without pancreatic diseases and twenty-five patients with pathologically confirmed pancreatic focal disease (ductal adenocarcinoma, n = 14; endocrine tumour, n = 8; focal chronic pancreatitis, n = 3), underwent MRI by 3 T-device. Multiphasic contrast-enhanced MR perfusion, consisting of a 3D axial navigator, based free-breathing T1-weighted DISCO sequence, was repeated for 5 min. Read More

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http://dx.doi.org/10.1016/j.mri.2019.03.001DOI Listing
June 2019
1 Read

The utility of Gallium-DOTATATE PET/CT in the detection of von Hippel-Lindau disease associated tumors.

Eur J Radiol 2019 Mar 22;112:130-135. Epub 2018 Nov 22.

Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States; Department of Surgery, The George Washington University, School of Medicine and Health Sciences, Washington, District of Columbia, United States.

Purpose: Patients with von Hippel-Lindau (VHL) disease may develop various tumors, including neuroendocrine tumors of the pancreas (PNETs) and adrenal, central nervous system and retinal hemangioblastomas, kidney tumors and more. Ga-DOTATATE positron emission tomography (PET)/computerized tomography (CT) has been shown to be highly accurate for tumors with cells expressing somatostatin receptors. We aimed to assess the performance of Ga-DOTATATE PET/CT in patients with VHL disease. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.11.023DOI Listing
March 2019
1 Read

[A Case of Male Breast Cancer Suspected of Breast Metastasis from Pancreatic Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):1857-1859

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

History of male breast cancer and pancreatic cancer are important for diagnosis of hereditary breast and ovarian cancer syndrome(HBOC), while advanced pancreatic cancer is reported to have metastasis to mammary gland tissue. A 67-year-old man visited a local hospital because fever and right hypochondrial pain. Computed tomography scan revealed pancreatic cancer with multiple liver metastasis and peritoneal metastasis. Read More

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December 2018
21 Reads

Serum chromogranin A for the diagnosis of gastroenteropancreatic neuroendocrine neoplasms and its association with tumour expression.

Oncol Lett 2019 Feb 5;17(2):1497-1504. Epub 2018 Dec 5.

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China.

The aim of the present study was to assess the clinical value of serum chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) and to compare them with tumour expression of CgA. A total of 109 consecutive patients with confirmed GEP-NENs were enrolled in this prospective study between December 2012 and August 2016, including 73 patients with primary or recurrent GEP-NENs and 36 patients with GEP-NENs that were treated following surgery. Furthermore, 30 patients with benign gastrointestinal diseases and 30 healthy volunteers served as control groups. Read More

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http://dx.doi.org/10.3892/ol.2018.9795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341841PMC
February 2019
4 Reads
0.987 Impact Factor

Viscothionin purified from mistletoe (Viscum album var. coloratum Ohwi) induces insulin secretion from pancreatic beta cells.

J Ethnopharmacol 2019 Apr 17;234:172-179. Epub 2019 Jan 17.

Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 580-185, Republic of Korea.

Ethnopharmacological Relevance: Mistletoe (Viscum album), an evergreen parasitic plant, has been widely used as an oriental phytomedicine to treat diabetes mellitus. However, it is unknown which mistletoe constituent exerts the beneficial effect against the disease. In this study, we examined the hypoglycemic activity of mistletoe and investigated whether the polypeptide viscothionin, purified from mistletoe, was responsible for the activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183254
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http://dx.doi.org/10.1016/j.jep.2019.01.014DOI Listing
April 2019
21 Reads

Pancreatic cancer - summary of the session of 6th International Pancreatic Days in Gdynia 27-30 October 2016.

Pol Przegl Chir 2018 Dec;90(6):1-6

Medical University of Gdańsk, Poland Department of General Endocrine and Transplant Surgery.

The session participants were Prof. Caroline Verbeke (CV) from The Department of Pathology Oslo University and Prof. Marcus Wolfgang Büchler (WMB) from the Department of General, Visceral and Transplantation Surgery at the University Hospital Heidelberg. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7408DOI Listing
December 2018
2 Reads

The prognosis and management of neuroendocrine neoplasms-related metastatic bone disease: lessons from clinical practice.

Endocrine 2019 Jan 11. Epub 2019 Jan 11.

The ARDEN NET Centre, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK.

Purpose: To study the evolution and optimal management of metastatic bone disease (mBD) in patients with neuroendocrine neoplasms (NENs).

Methods: Seventy-four patients were recruited from four NEN centers in this observational multicenter study.

Results: Pancreas and small bowel were the most common primaries (30 and 27%, respectively). Read More

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http://dx.doi.org/10.1007/s12020-019-01838-8DOI Listing
January 2019
4 Reads
3.527 Impact Factor

Isolated Langerhans islets: Potential pitfall in solid and pseudopapillary neoplasm resection?

Eur J Surg Oncol 2019 03 21;45(3):487-488. Epub 2018 Dec 21.

APHP GHU Avicenne, Bobigny, France; Universite Paris Nord, UFR SMBH Bobigny, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2018.12.002DOI Listing
March 2019
1 Read

A case of malignant insulinoma responsive to somatostatin analogs treatment.

BMC Endocr Disord 2018 Dec 27;18(1):98. Epub 2018 Dec 27.

Endocrine Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Careggi University Hospital, Florence, Italy.

Background: Insulinoma is a rare tumour representing 1-2% of all pancreatic neoplasms and it is malignant in only 10% of cases. Locoregional invasion or metastases define malignancy, whereas the dimension (> 2 cm), CK19 status, the tumor staging and grading (Ki67 > 2%), and the age of onset (> 50 years) can be considered elements of suspect.

Case Presentation: We describe the case of a 68-year-old man presenting symptoms compatible with hypoglycemia. Read More

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http://dx.doi.org/10.1186/s12902-018-0325-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307122PMC
December 2018
3 Reads

Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells.

Cell Physiol Biochem 2018 7;51(5):2185-2197. Epub 2018 Dec 7.

Department of Medicine, The University of Chicago, Chicago, Illinois,

Background/aims: VCP-interacting membrane selenoprotein (VIMP), an ER resident selenoprotein, is highly expressed in β-cells, however, the role of VIMP in β-cells has not been characterized. In this study, we studied the relationship between VIMP deficiency and β-cell survival in MIN6 insulinoma cells.

Methods: To determine the role of VIMP in β-cells, lentiviral VIMP shRNAs were used to knock down (KD) expression of VIMP in MIN6 cells. Read More

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https://www.karger.com/Article/FullText/495865
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http://dx.doi.org/10.1159/000495865DOI Listing
January 2019
3 Reads

Volumetric decrease of pancreas after abdominal irradiation, it is time to consider pancreas as an organ at risk for radiotherapy planning.

Radiat Oncol 2018 Dec 3;13(1):238. Epub 2018 Dec 3.

Department of Radiation Oncology, Dr. Lutfi Kirdar Kartal Education and Research Hospital, Istanbul, Turkey.

Background: Volumetric shrinkage of normal tissues such as salivary glands, kidneys, hippocampus are observed after radiotherapy. We aimed to assess the alterations in pancreatic volume of patients who received abdominal radiotherapy and define pancreas as an organ at risk for radiation treatment planning.

Material-methods: Forty-nine patients operated for gastric adenocarcinoma who received adjuvant abdominal radiotherapy were in the study group, 27 patients with early stage disease who did not need adjuvant treatment after surgery comprised the control group. Read More

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http://dx.doi.org/10.1186/s13014-018-1189-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276196PMC
December 2018
4 Reads

Leptomeningeal metastases of a well-differentiated neuroendocrine tumour: a rare entity.

BMJ Case Rep 2018 Nov 3;2018. Epub 2018 Nov 3.

Department of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

A 73-year-old man, without any medical history, had presented with dark urine and pale stool without pain. Diagnostic imaging revealed a tumour in the pancreas with liver metastases. Histopathological examination showed a well-differentiated pancreatic neuroendocrine tumour. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22655
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http://dx.doi.org/10.1136/bcr-2018-226557DOI Listing
November 2018
19 Reads

The epithelial-mesenchymal transition induces aggressivity of mucinous cystic neoplasm of the pancreas with neuroendocrine component: An immunohistochemistry study.

Pathol Res Pract 2019 Jan 23;215(1):82-89. Epub 2018 Oct 23.

Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, Targu Mures, Romania.

Background: Pancreatic mucinous cystic neoplasms (MCN) are rare tumors that are usually diagnosed in females.

Materials And Methods: In our department, only four of the 109 consecutive cases of pancreatic tumors (3.67%) were diagnosed as MCNs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183107
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http://dx.doi.org/10.1016/j.prp.2018.10.019DOI Listing
January 2019
15 Reads

Gene Therapy for Pancreatic Diseases: Current Status.

Int J Mol Sci 2018 Oct 31;19(11). Epub 2018 Oct 31.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Aasahimachi-Dori, Chuo-Ku, Niigata 951-8510, Japan.

The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various therapeutic methodologies have been established to date, however, the improvement of conventional treatments and establishment of novel therapies are essential to improve the efficacy. Read More

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http://www.mdpi.com/1422-0067/19/11/3415
Publisher Site
http://dx.doi.org/10.3390/ijms19113415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275054PMC
October 2018
9 Reads

Surgical treatment of congenital hyperinsulinism: Results from 500 pancreatectomies in neonates and children.

J Pediatr Surg 2019 Jan 5;54(1):27-32. Epub 2018 Oct 5.

Department of Pediatrics and the Congenital Hyperinsulinism Center, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: Congenital Hyperinsulinism (HI) causes severe hypoglycemia in neonates and children. We reviewed our experience with pancreatectomy for the various types of HI.

Methods: From 1998 to 2018, 500 patients with HI underwent pancreatectomy: 246 for focal HI, 202 for diffuse HI, 37 for atypical HI (16 for Localized Islet Nuclear Enlargement [LINE], 21 for Beckwith-Wiedemann Syndrome), and 15 for insulinoma. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339589PMC
January 2019
2 Reads

Natural History of Small Pancreatic Lesions Suspected to Be Nonfunctioning Pancreatic Neuroendocrine Tumors.

Pancreas 2018 Nov/Dec;47(10):1357-1363

From the Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objectives: Nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are a rare disease but have been diagnosed more frequently than before. The aim of this study was to evaluate the natural course of small NF-PNETs.

Methods: We performed a retrospective analysis of patients with incidentally found small NF-PNETs (<20 mm) from 1999 to 2015. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001187DOI Listing
March 2019
4 Reads

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms

Eur J Endocrinol 2018 10 1;179(4):219-228. Epub 2018 Oct 1.

‘Lendület’ Hereditary Endocrine Tumours Research Group, Hungarian Academy of Sciences – Semmelweis University, Budapest, Hungary

Objective: Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to identify miRNAs with altered expression upon proliferation which can be used as prognostic biomarkers in PanNENs. Read More

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https://eje.bioscientifica.com/view/journals/eje/179/4/EJE-1
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http://dx.doi.org/10.1530/EJE-18-0305DOI Listing
October 2018
14 Reads

Pancreatic mixed acinar-neuroendocrine carcinoma, a unique diagnostic challenge on FNA cytology: A small series of two cases with literature review.

Diagn Cytopathol 2018 Nov 3;46(11):971-976. Epub 2018 Oct 3.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.

Mixed acinar-neuroendocrine carcinoma (MANEC) of the pancreas is a rare tumor. We present two cases of MANEC diagnosed on endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA). The first patient is a 33-year-old male who had a 3. Read More

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http://doi.wiley.com/10.1002/dc.23981
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http://dx.doi.org/10.1002/dc.23981DOI Listing
November 2018
10 Reads

Unmet Needs in Functional and Nonfunctional Pancreatic Neuroendocrine Neoplasms.

Neuroendocrinology 2019 3;108(1):26-36. Epub 2018 Oct 3.

Gastrointestinal and Neuroendocrine Oncology Unit, European Institute of Oncology (IEO), Milan, Italy.

Recently, the European Neuroendocrine Tumor Society (ENETS) held working sessions composed of members of the advisory board and other neuroendocrine neoplasm (NEN) experts to attempt to identify unmet needs in NENs in different locations or with advanced/poorly differentiated NENs. This report briefly summarizes the main proposed areas of unmet needs in patients with functional and nonfunctional pancreatic NENs. Read More

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http://dx.doi.org/10.1159/000494258DOI Listing
October 2018
11 Reads
4.373 Impact Factor

A "Clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques.

Adv Anat Pathol 2019 Jan;26(1):31-39

Departments of Pathology.

Although pathologic lesions in the pancreas are 3-dimensional (3D) complex structures, we currently use thin 2D hematoxylin and eosin stained slides to study and diagnose pancreatic pathology. Two technologies, tissue clearing and advanced microscopy, have recently converged, and when used together they open the remarkable world of 3D anatomy and pathology to pathologists. Advances in tissue clearing and antibody penetration now make even dense fibrotic tissues amenable to clearing, and light sheet and confocal microscopies allow labeled cells deep within these cleared tissues to be visualized. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000215DOI Listing
January 2019
15 Reads

Unmet Needs in Appendiceal Neuroendocrine Neoplasms.

Neuroendocrinology 2019 20;108(1):37-44. Epub 2018 Sep 20.

Department of Pathology, Gustave Roussy Cancer Campus, Villejuif, France.

Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered coincidentally during appendicectomy and usually have a benign clinical course; thus, appendicectomy alone is considered curative. However, in some cases, a malignant potential is suspected, and therefore additional operations such as completion right hemicolectomy are considered. The existing European Neuroendocrine Tumour Society (ENETS) guidelines provide useful data about epidemiology and prognosis, as well as practical recommendations with regards to the risk factors for a more aggressive disease course and the indications for a secondary operation. Read More

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http://dx.doi.org/10.1159/000493894DOI Listing
September 2018
4 Reads
4.373 Impact Factor

The Diagnosis and Clinical Significance of Paragangliomas in Unusual Locations.

J Clin Med 2018 Sep 13;7(9). Epub 2018 Sep 13.

Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada.

Paragangliomas are neuroendocrine neoplasms, derived from paraganglia of the sympathetic and parasympathetic nervous systems. They are most commonly identified in the head and neck, being most frequent in the carotid body, followed by jugulotympanic paraganglia, vagal nerve and ganglion nodosum, as well as laryngeal paraganglia. Abdominal sites include the well-known urinary bladder tumors that originate in the Organ of Zuckerkandl. Read More

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http://www.mdpi.com/2077-0383/7/9/280
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http://dx.doi.org/10.3390/jcm7090280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162705PMC
September 2018
23 Reads

Perioperative complications of adrenalectomy - 12 years of experience from a single center/teaching hospital and literature review.

Arch Med Sci 2018 Aug 20;14(5):1010-1019. Epub 2018 Jul 20.

1 Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.

Introduction: The perioperative complication rate of adrenalectomy varies between 1.7% and 30.7% in the medical literature. Read More

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http://dx.doi.org/10.5114/aoms.2018.77257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111348PMC
August 2018
24 Reads

Solid pseudopapillary neoplasms of the pancreas do not express major pancreatic markers in pediatric patients.

Hum Pathol 2019 Jan 18;83:29-35. Epub 2018 Aug 18.

Department of Pathology, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, and Université Paris Descartes, 75015 Paris, France. Electronic address:

Solid pseudopapillary neoplasms (SPNs) of the pancreas are classified as "exocrine" pancreatic tumors by the World Health Organization. However, despite numerous studies using immunohistochemistry, electron microscopy, animal models, and molecular biology, the histogenesis of SPN remains unclear. At the same time, our knowledge of human pancreas development has significantly increased. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.08.010DOI Listing
January 2019
4 Reads

Solid Pseudo-Papillary Tumor Mimicking as Complicated Pseudocyst: Multimodality Imaging and Pathological Correlation.

Clin Nucl Med 2018 Oct;43(10):e368-e371

Radiology, Medical Imaging, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.

Pancreatic neoplasm is very rare in the pediatric population. Malignant tumors represent less than 0.2% of pediatric cancer-related mortality. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002225DOI Listing
October 2018
4 Reads

[Endocrine Organ Dysfunction with Immune-Checkpoint Inhibitors].

Gan To Kagaku Ryoho 2018 Jul;45(7):1031-1035

The First Dept. of Medicine, Dept. of Diabetes, Endocrinology and Metabolism, Wakayama Medical University.

Cytotoxic T-lymphocyte associated antigen 4(CTLA-4), programmed death 1(PD-1), and programmed death-ligand 1 (PD-L1)are referred to as immune-checkpoints. CTLA-4 is located on the surface of activated T-cells, therefore inhibiting binding of CD28 to B7 molecule on antigen presenting cells. The CTLA-4 pathway predominantly acts in lymph nodes. Read More

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July 2018
23 Reads

Bacterial supernatants elevate glucose-dependent insulin secretion in rat pancreatic INS-1 line and islet β-cells via PI3K/AKT signaling.

Mol Cell Biochem 2019 Feb 23;452(1-2):17-27. Epub 2018 Jul 23.

Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zurich, Plattenstrasse 11, 8032, Zurich, Switzerland.

Diabetes and periodontitis are considered associated chronic diseases, and hyperinsulinemia in prediabetes has been shown to be present in normoglycemic animals with periodontitis. As periodontal bacterial species are significant sources of endotoxemia and may directly stimulate insulin secretion, we hypothesized that increased bacterial virulence may exert an adverse effect on rat pancreatic β-cell function via PI3K/AKT signaling. INS-1 cells and isolated pancreatic islets were cultured separately with the following supernatants: Streptococcus anginosus, Streptococcus mutans, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas gingivalis (P. Read More

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http://dx.doi.org/10.1007/s11010-018-3408-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373304PMC
February 2019
1 Read

Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway.

Mol Cell Biochem 2019 Feb 18;452(1-2):83-94. Epub 2018 Jul 18.

Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.

The objective was to investigate the mechanism of the protective effect of silibinin on amylin/Aβ-induced INS-1 cell apoptosis, with special reference to the roles of glucagon-like peptide-1 receptor (GLP-1R) and protein kinase A (PKA). The effects of silibinin on apoptosis, insulin secretion, GLP-1R, and PKA expression in the INS-1 cells treated with amylin/Aβ were examined. INS-1 cells exposed to amylin showed increased TUNEL-positive ratio, reduced expression of GLP-1R and PKA. Read More

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http://dx.doi.org/10.1007/s11010-018-3414-9DOI Listing
February 2019
3 Reads

Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells.

J Biol Chem 2018 09 16;293(37):14210-14223. Epub 2018 Jul 16.

From the Departments of Biological Sciences and Biomedical Sciences, George Washington University, Washington, D. C. 20052

Human islet amyloid polypeptide (hIAPP) is the principal constituent of amyloid deposits and toxic oligomers in the pancreatic islets. Together with hyperglycemia, hIAPP-derived oligomers and aggregates are important culprits in type 2 diabetes mellitus (T2DM). Here, we explored the role of the cell's main proteolytic complex, the proteasome, in hIAPP turnover in normal and stressed β-cells evoked by chronic hyperglycemia. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.002414
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http://dx.doi.org/10.1074/jbc.RA118.002414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139561PMC
September 2018
10 Reads

Current treatment strategies for patients with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs).

Clin Diabetes Endocrinol 2018 11;4:16. Epub 2018 Jul 11.

Neuroendocrine Tumor Unit, Endocrinology and Metabolism Department, Division of Medicine, Hadassah-Hebrew University Medical Center, P.O.B. 12000, 91120 Jerusalem, Israel.

Background: Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. Read More

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http://dx.doi.org/10.1186/s40842-018-0066-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042326PMC
July 2018
12 Reads

Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms.

Eur J Endocrinol 2018 Jul 13. Epub 2018 Jul 13.

A Patocs, "Lendulet" Hereditary Endocrine Tumors Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.

Objective Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas, however their prognosis differs significantly upon their proliferative state which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expression. Our aim was to identify miRNAs with altered expression upon proliferation which can be used as prognostic biomarkers in PanNENs. Read More

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http://dx.doi.org/10.1530/EJE-18-0305DOI Listing
July 2018
6 Reads

Ectopic insulinomas in the pelvis secondary to rectum neuroendocrine tumour.

BMJ Case Rep 2018 Jun 29;2018. Epub 2018 Jun 29.

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.

We describe a middle-aged woman with recurrent hypoglycaemia, who confirmed with rectum G1 neuroendocrine tumour (NET) 6 years ago. Biochemical assay showed high concentration of serum insulin and C-peptide associated with hypoglycaemia. Because of recurrent hypoglycaemia in June 2015, she underwent a resection of the tail of the pancreas. Read More

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http://dx.doi.org/10.1136/bcr-2018-224281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040560PMC
June 2018
28 Reads

Pro-inflammatory cytokines attenuate glucose-stimulated insulin secretion from INS-1E insulinoma cells by restricting mitochondrial pyruvate oxidation capacity - Novel mechanistic insight from real-time analysis of oxidative phosphorylation.

PLoS One 2018 28;13(6):e0199505. Epub 2018 Jun 28.

School of Biomedical and Healthcare Sciences, University of Plymouth, Plymouth, United Kingdom.

Pro-inflammatory cytokines cause pancreatic beta cell failure during the development of type 2 diabetes. This beta cell failure associates with mitochondrial dysfunction, but the precise effects of cytokines on mitochondrial respiration remain unclear. To test the hypothesis that pro-inflammatory cytokines impair glucose-stimulated insulin secretion (GSIS) by inhibiting oxidative ATP synthesis, we probed insulin release and real-time mitochondrial respiration in rat INS-1E insulinoma cells that were exposed to a combination of 2 ng/mL interleukin-1-beta and 50 ng/mL interferon-gamma. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199505PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023166PMC
April 2019
37 Reads

Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses.

J Biol Chem 2018 08 25;293(32):12516-12524. Epub 2018 Jun 25.

From the Research Institute of the McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada,

One feature of diabetes is the failure of pancreatic β cells to produce insulin, but the molecular mechanisms leading to this failure remain unclear. Increasing evidence supports a role for protein kinase R-like endoplasmic reticulum kinase (PERK) in the development and function of healthy pancreatic β cells. Previously, our group identified the adaptor protein Nck1 as a negative regulator of PERK. Read More

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http://dx.doi.org/10.1074/jbc.RA118.002728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093234PMC
August 2018
1 Read

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors.

Diabetes 2018 08 24;67(8):1471-1480. Epub 2018 Jun 24.

Section of Endocrinology and Metabolism, Department of Internal Medicine, Yale University, New Haven, CT

Insulin-dependent diabetes may occur in patients with cancers who are treated with checkpoint inhibitors (CPIs). We reviewed cases occurring over a 6-year period at two academic institutions and identified 27 patients in whom this developed, or an incidence of 0.9%. Read More

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/dbi1
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http://dx.doi.org/10.2337/dbi18-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054443PMC
August 2018
24 Reads

Neoplasms of the Neuroendocrine Pancreas: An Update in the Classification, Definition, and Molecular Genetic Advances.

Adv Anat Pathol 2019 Jan;26(1):13-30

Departments of Pathology, Massachusetts General Hospital, Boston, MA.

This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000201DOI Listing
January 2019
28 Reads

Incidental Neuroendocrine Tumor Discovered After Total Pancreatectomy Intended for Islet Autotransplantation: Important Considerations for Surgical Decision-Making.

Pancreas 2018 07;47(6):778-782

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota Medical School, Minneapolis, MN.

Total pancreatectomy (TP) is a treatment option for patients experiencing chronic pancreatitis (CP) refractory to medical management. Patients who are candidates for TP benefit from islet autotransplantation (IAT), which preserves available β-cell mass and thereby reduces the risk of brittle diabetes. Malignancy is an absolute contraindication for IAT to prevent the transplantation of occult malignant cells. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001069DOI Listing
July 2018
6 Reads

Quantitative determination of pancreas size using anatomical landmarks and its clinical relevance: A systematic literature review.

Clin Anat 2018 Sep 18;31(6):913-926. Epub 2018 Oct 18.

Department of Surgery, University of Auckland, Auckland, 1023, New Zealand.

There have been many reports of altered pancreas size in diseases of the endocrine and exocrine pancreas, but few attempts to quantify such changes. The aim of this study was to conduct a systematic literature review, documenting the methodology, and quantitative data in studies reporting on pancreas size. Three electronic databases (Embase, Scopus, and MEDLINE) were searched by two reviewers independently. Read More

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http://dx.doi.org/10.1002/ca.23217DOI Listing
September 2018
6 Reads

Not only stem cells, but also mature cells, particularly neuroendocrine cells, may develop into tumours: time for a paradigm shift.

Therap Adv Gastroenterol 2018 27;11:1756284818775054. Epub 2018 May 27.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Stem cells are considered the origin of neoplasms in general, and malignant tumours in particular, and the stage at which the stem cells stop their differentiation determines the degree of malignancy. However, there is increasing evidence supporting an alternative paradigm. Tumours may develop by dedifferentiation from mature cells able to proliferate. Read More

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http://dx.doi.org/10.1177/1756284818775054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974566PMC
May 2018
19 Reads

Diabetes after pancreaticoduodenectomy: can we predict it?

J Surg Res 2018 07 20;227:211-219. Epub 2018 Mar 20.

Department of Gastrointestinal Surgery and Liver Transplantation, All India Institute of Medical Sciences, New Delhi, India.

Background: There is limited literature about the perioperative factors which can predict endocrine insufficiency after pancreaticoduodenectomy (PD). The primary aim was to correlate percentage pancreatic remnant volume (%RV) after PD in nondiabetic patients with the development of new-onset impaired glucose tolerance/diabetes mellitus (IGT/DM). The secondary aim was to identify the risk factors for new-onset IGT/DM. Read More

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http://dx.doi.org/10.1016/j.jss.2018.02.010DOI Listing
July 2018
4 Reads

[Insulinoma found in patient with apparent mental disorder: a case report].

Rev Gastroenterol Peru 2018 Jan-Mar;38(1):82-84

Facultad de Medicina, Universidad Nacional de San Agustín. Arequipa, Perú; Sociedad Científica de Estudiantes de Medicina Agustinos (SOCIEMA). Arequipa, Perú.

Pancreatic Insulinoma is a neuroendocrine tumor of the beta cells of the islets of Langerhans, has an incidence of 4 cases per 1 000 000 persons. We report the case of a 36-year-old woman with altered behavior associated with melancholy. Psychiatry describes an abnormal mental examination and diagnosed double depression; however, the patient had the Whipple triad and insulin/glucose ratio higher than 0. Read More

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November 2018
6 Reads

Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract: 2018 Update.

Clin Lab Med 2018 06;38(2):367-384

Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo-SUNY, Buffalo General Hospital A-701, 100 High Street, Buffalo, NY 14203, USA. Electronic address:

Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Read More

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http://dx.doi.org/10.1016/j.cll.2018.03.003DOI Listing
June 2018
12 Reads

An unusual finding in a desmoid-type fibromatosis of the pancreas: a case report and review of the literature.

J Med Case Rep 2018 May 12;12(1):123. Epub 2018 May 12.

Department of Endocrine and Breast Surgery, First Affiliated Hospital of Chongqing Medical University, No.1 Yixueyuan Rd, Yuzhong District, Chongqing, 400016, People's Republic of China.

Background: Desmoid-type fibromatoses are rare benign and fibrous tumors that account for approximately 0.03% of total neoplasms. Within this category of neoplasms, pancreatic desmoid-type fibromatosis is an extremely rare subgroup, accounting for approximately 5% of desmoid-type fibromatoses. Read More

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http://dx.doi.org/10.1186/s13256-018-1635-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948877PMC
May 2018
7 Reads

Peptide Receptor Radionuclide Therapy for Advanced Gastroenteropancreatic Neuroendocrine Tumors - from oncology perspective.

Nucl Med Rev Cent East Eur 2018 ;21(2)

Maria Sklodowska-Curie Memorial Cancer Center and Institiute of Oncology, Wawelska 15, 02-034 Warszawa, Poland.

Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e. Read More

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https://journals.viamedica.pl/nuclear_medicine_review/articl
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http://dx.doi.org/10.5603/NMR.2018.0019DOI Listing
September 2018
19 Reads

Proteins of the retinoblastoma pathway, FEN1 and MGMT are novel potential prognostic biomarkers in pancreatic adenocarcinoma.

Pathol Res Pract 2018 Jun 1;214(6):840-847. Epub 2018 May 1.

Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland. Electronic address:

Background: We studied the expression of some major proteins involved in cell-cycle regulation and DNA repair, the roles of which are not well known in pancreatic ductal adenocarcinoma (PDAC), but which have a significant impact on carcinogenesis of many other cancers.

Methods: We immunohistochemically assessed expression levels of the cell-cycle regulators Rb1, p16 and cyclin-dependent kinase 4 (CDK4), and the DNA repair enzymes O6-methylguanine-DNA-alkyltransferase (MGMT) and flap endonuclease-1 (FEN1) separately in malignant tissue and benign tissue from resection margins in 102 cases of PDAC. Nearly all (95. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183015
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http://dx.doi.org/10.1016/j.prp.2018.04.016DOI Listing
June 2018
8 Reads

Association of Androgen Excess with Glucose Intolerance in Women with Polycystic Ovary Syndrome.

Biomed Res Int 2018 8;2018:6869705. Epub 2018 Mar 8.

Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, China.

Women with polycystic ovary syndrome (PCOS) show high prevalence of glucose intolerance. This study aimed to investigate the association of androgen excess with glucose intolerance in PCOS. A total of 378 women with PCOS participated in the study. Read More

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http://dx.doi.org/10.1155/2018/6869705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863307PMC
September 2018
15 Reads