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    5201 results match your criteria Neoplasms of the Endocrine Pancreas

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    Solid Pseudopapillary Tumor of the Pancreas: An Unusual Cause of Abdominal Pain.
    Cureus 2017 May 16;9(5):e1252. Epub 2017 May 16.
    Department of Gastroenterology, Staten Island University Hospital.
    Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor that accounts for less than one percent of pancreatic tumors. The diagnosis could be challenging as SPN tend to manifest with nonspecific abdominal symptoms, variable radiological features, and inconsistent morphology. The cellular origin of SPN is unclear and might involve ductal, acinar and endocrine stem cells. Read More

    Management of a multiple endocrine neoplasia type 1 during pregnancy: A case report and review of the literature.
    J Exp Ther Oncol 2016 Jul;11(3):217-220
    Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
    Multiple Endocrine Neoplasia Type 1 (MEN1) or Wermer's syndrome is a rare hereditary endocrine syndrome with high penetrance caused by mutations in MEN1 tumor suppressor gene. MEN1 is characterized by hyperplasia or tumoral enlargement in a number of endocrine organs (parathyroid glands, pancreas, pituitary gland, adrenal gland) and it could be hormonally active or inactive. MEN1 is a significant cause of morbidity due to hormone secretion and mass effect. Read More

    Severe chronic diarrhoea secondary to primary lymph node gastrinoma.
    BMJ Case Rep 2017 Apr 26;2017. Epub 2017 Apr 26.
    Gastroenterology, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
    The existence of primary lymph node (LN) gastrinoma is questionable and controversial. In fact, the presence of gastrinoma in such uncommon site raises the possibility of metastasis from another occult primary site. An extensive evaluation and careful follow-up is always warranted. Read More

    ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.
    J Huazhong Univ Sci Technolog Med Sci 2017 Apr 11;37(2):210-216. Epub 2017 Apr 11.
    Department of Gynecology and Obstetrics, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
    This study investigated the abnormal expression of ATP synthase β-subunit (ATPsyn-β) in pancreas islets of rat model of polycystic ovary syndrome (PCOS) with type 2 diabetes mellitus (T2DM), and the secretion function changes after up-regulation of ATP5b. Sixty female SD rats were divided into three groups randomly and equally. The rat model of PCOS with T2DM was established by free access to the high-carbohydrate/high-fat diet, subcutaneous injections of DHEA, and a single injection of streptozotocin. Read More

    Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report.
    Surg Case Rep 2017 Dec 30;3(1):51. Epub 2017 Mar 30.
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka City, Osaka, 537-8511, Japan.
    Background: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were treated with surgery and transcatheter arterial chemoembolization (TACE) that later recurred in the stomach. Read More

    Disseminated Pancreatic Neuroendocrine Neoplasm (NEN) with an Uncommon Localisation in the Central Nervous System. A Case Report.
    Pol J Radiol 2017 1;82:120-125. Epub 2017 Mar 1.
    Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland; Department of Radiology, Clinical University Hospital in Olsztyn, Olsztyn, Poland.
    Background: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1. Read More

    Neuroendocrine Tumors in the Stomach, Duodenum, and Pancreas Accompanied by Novel MEN1 Gene Mutation.
    Korean J Gastroenterol 2017 Mar;69(3):181-186
    Division of Gastroenterology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.
    Multiple endocrine neoplasia type 1 (MEN1) syndrome is a relatively rare disease, characterized by the occurrence of multiple endocrine tumors in the parathyroid and pituitary glands as well as the pancreas. Here, we report a case of MEN1 with neuroendocrine tumors (NETs) in the stomach, duodenum, and pancreas. A 53-year-old man visited our hospital to manage gastric NET. Read More

    East Versus West: Differences in Surgical Management in Asia Compared with Europe and North America.
    Surg Clin North Am 2017 Apr;97(2):453-466
    Department of Gastroentelogical, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Yamaguchi 755-8505, Japan.
    In recent decades, there has been considerable worldwide progress in the treatment of gastric cancer. Gastrectomy with a modified D2 lymphadenectomy (sparing the distal pancreas and spleen) has increasingly gained acceptance as a preferable standard surgical approach among surgeons in the East and the West. Despite growing consensus significant differences still exist in surgical techniques in clinical trials and clinical practices secondary to variations in epidemiology, clinicopathologic features, and surgical outcomes among geographic regions. Read More

    9-cis Retinoic acid modulates myotrophin expression and its miR in physiological and pathophysiological cell models.
    Exp Cell Res 2017 May 12;354(1):25-30. Epub 2017 Mar 12.
    Department of Pharmacy, Heath and Nutritional Sciences, University of Calabria, 87036, Rende, CS, Italy. Electronic address:
    Functional studies indicate that essential cellular processes are controlled by Vitamin A derivatives. Among these the retinoic acid isoforms, all-trans- and 9-cis (9cRA), regulate the expression of various genes in both physiological and pathological conditions. Using several in vitro experimental models such as pancreatic β-cells, pre-adipocytes and breast cancer cells with different phenotypes, we demonstrated the capability of 9cRA to modulate myotrophin (Mtpn) and miR-375 expressions. Read More

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
    BMC Gastroenterol 2017 Mar 7;17(1):37. Epub 2017 Mar 7.
    Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
    Background: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. Read More

    Laparoscopic splenopancreatectomy for an endocrine tumor with cystic changes: a case report.
    Clin Case Rep 2017 Mar 6;5(3):328-332. Epub 2017 Feb 6.
    Department of Gastrointestinal Surgery Tokai University School of Medicine 143 Shimokasuya Isehara Kanagawa 259-1193 Japan.
    The biological behavior of a cystic pancreatic endocrine neoplasm is less aggressive than that of pancreatic neuroendocrine neoplasms, and its prognosis is better. Limited surgery should be considered for cystic pancreatic endocrine neoplasms that are not accompanied preoperatively by lymph node or distant metastasis. Read More

    7, 8-Dihydroxycoumarin (daphnetin) protects INS-1 pancreatic β-cells against streptozotocin-induced apoptosis.
    Phytomedicine 2017 Jan 1;24:119-126. Epub 2016 Dec 1.
    Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong 519085, China. Electronic address:
    Background And Objective: Daphnetin (7, 8-dihydroxycoumarin), a natural coumarin compound, is known to exhibit antioxidant and anti-inflammatrory effects. However, the underlying mechanisms of its anti-apoptotic and antidiabetic effects yet not been examined. Therefore, the present work studied the anti-apoptotic and anti-diabetic effects of daphnetin by in vitro experiments. Read More

    Cystic degeneration of neuro endocrine tumor of pancreas and Crohn's disease: true or coincidental association?
    Pan Afr Med J 2016 15;25. Epub 2016 Sep 15.
    Department Of Surgery, FSI Hospital, Marsa, Tunisia.
    Pancreatic endocrine tumors (PETs) or islet cell tumors are rare lesions, the incidence of which is estimated to be less than 1 per 100,000 person-years in the general population. PETs can be divided into functional (exhibit a distinct clinical syndrome due to hormone hypersecretion) and non-functional tumors. The majority of PETs are non-functional. Read More

    A case of concomitant colitic cancer and intrahepatic cholangiocarcinoma during follow-up for ulcerative colitis.
    Clin J Gastroenterol 2017 Apr 30;10(2):157-162. Epub 2017 Jan 30.
    Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
    Colitis-associated colorectal cancer (CAC) is known to occur in long-standing and extensive ulcerative colitis (UC). Furthermore, UC is known to complicate primary sclerosing cholangitis (PSC), which subsequently results in an increased risk of developing cholangiocarcinoma. We report a case of colitis-associated rectal cancer (CARC) accompanied by intrahepatic cholangiocarcinoma (ICC) based on UC and PSC. Read More

    Acute pancreatitis after thoracic duct ligation for iatrogenic chylothorax. A case report.
    BMC Surg 2017 Jan 23;17(1). Epub 2017 Jan 23.
    Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1211, Geneva, Switzerland.
    Background: To report the association between thoracic duct ligation and acute pancreatitis. The association between sudden stop of lymphatic flow and pancreatitis has been established in experimental models.

    Case Presentation: A 57-year-old woman operated for thymoma presented a iatrogenic chylothorax. Read More

    Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis.
    Diabetes 2017 Feb;66(2):235-240
    Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Glucagon is usually viewed as an important counterregulatory hormone in glucose metabolism, with actions opposing those of insulin. Evidence exists that shows glucagon is important for minute-to-minute regulation of postprandial hepatic glucose production, although conditions of glucagon excess or deficiency do not cause changes compatible with this view. In patients with glucagon-producing tumors (glucagonomas), the most conspicuous signs are skin lesions (necrolytic migratory erythema), while in subjects with inactivating mutations of the glucagon receptor, pancreatic swelling may be the first sign; neither condition is necessarily associated with disturbed glucose metabolism. Read More

    A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report.
    Diagn Pathol 2017 Jan 19;12(1):10. Epub 2017 Jan 19.
    Department of Pathology, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, 567 Baekje-daero, Dukjin-gu, Jeonju, 561-756, Republic of Korea.
    Background: Acinar cell carcinoma represents only 1-2% of exocrine pancreatic neoplasms. On exceptionally rare occasions, primary acinar cell carcinoma can occur in ectopic locations. Herein, we report a case of pure pancreatic-type acinar cell carcinoma arising in the stomach. Read More

    Chemoembolization of Neuroendocrine Liver Metastases Using Streptozocin and Tris-acryl Microspheres: Embozar (EMBOsphere + ZAnosaR) Study.
    Cardiovasc Intervent Radiol 2017 Mar 29;40(3):394-400. Epub 2016 Dec 29.
    Department of Hepatogastroenterology and Oncology, Hopital Ambroise Pare, 9, Avenue Charles de Gaulle, 92104, Boulogne Cedex, France.
    Purpose: The purpose of this prospective observational study was to evaluate the efficacy and tolerability of transarterial chemoembolization (TACE) for neuroendocrine liver metastases using a combination of streptozocin, Lipiodol, and tris-acryl microspheres.

    Patients And Methods: A total of 16 men and 9 women aged 59.6 ± 11. Read More

    Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology.
    World J Gastroenterol 2016 Dec;22(45):9944-9953
    Stefano Crippa, Stefano Partelli, Marco Palucci, Francesca Muffatti, Olga Adamenko, Massimo Falconi, Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Vita e Salute University, 20132 Milan, Italy.
    Neuroendocrine carcinomas (NEC) of the pancreas are defined by a mitotic count > 20 mitoses/10 high power fields and/or Ki67 index > 20%, and included all the tumors previously classified as poorly differentiated endocrine carcinomas. These latter are aggressive malignancies with a high propensity for distant metastases and poor prognosis, and they can be further divided into small- and large-cell subtypes. However in the NEC category are included also neuroendocrine tumors with a well differentiated morphology but ki67 index > 20%. Read More

    A rare case of metastasized non-functional pancreatic neuroendocrine tumor with a good long-term survival.
    J Med Life 2016 Oct-Dec;9(4):369-372
    "C. I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
    Background: Non-functional neuroendocrine tumors of the pancreas (NF-pNETs) are a varied group of extremely rare malignancies. The majority of patients already have liver metastases at the diagnosis moment, thus, treatment options are restricted, and the survival rate is reserved. Case report: We presented the case of 59-year-old patient, diagnosed with non-functional well-differentiated pancreatic neuroendocrine tumor grade II (NET G2) with the presence of chromogranin A, synaptophysin and somatostatin receptor 2, together with liver and bone metastases. Read More

    Connexins and pannexins: from biology towards clinical targets.
    Swiss Med Wkly 2016 5;146:w14365. Epub 2016 Dec 5.
    Department of Medicine, Université de Lausanne, Lausanne, Switzerland.
    Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Read More

    Enucleation: A treatment alternative for branch duct intraductal papillary mucinous neoplasms.
    Surgery 2017 Mar 22;161(3):602-610. Epub 2016 Nov 22.
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address:
    Background: Small, asymptomatic, branch-duct intraductal papillary mucinous neoplasms of the pancreas are often kept under surveillance despite their malignant potential. The management of branch-duct intraductal papillary mucinous neoplasm is controversial with regard to indications and extent of any operative intervention. The present study aimed to evaluate enucleation as an alternative operative approach for branch-duct intraductal papillary mucinous neoplasms to exclude and prevent malignancy. Read More

    Autophagy protects against cholesterol-induced apoptosis in pancreatic β-cells.
    Biochem Biophys Res Commun 2017 Jan 16;482(4):678-685. Epub 2016 Nov 16.
    Department of Endocrinology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China. Electronic address:
    Autophagy is believed to play an important role in maintaining homeostasis in pancreatic β-cells during insulin resistance. This study investigated the role of autophagy in β-cell damage induced by cholesterol and its possible activation mechanism. Rat and mouse pancreatic β-cell lines INS-1 and βTC-6 were incubated with cholesterol alone or in combination with autophagy inhibitors E-64d/Pepstatin A or bafilomycin A1. Read More

    Giant insulinoma: report of a case and review of published reports.
    Surg Case Rep 2016 Dec 19;2(1):136. Epub 2016 Nov 19.
    Department of Surgery, Hitachi General Hospital, 2-1-1 Jonan-cho, Hitachi, Ibaraki, 317-0077, Japan.
    Background: Larger insulinomas are reportedly more likely to be malignant; however, their biological behavior has not been clearly elucidated. We here report the characteristics and treatment of a giant insulinoma with local invasion and lymph node metastasis. We also review published reports concerning the clinical features of giant insulinomas and comparing their grading with that of pancreatic neuroendocrine tumors. Read More

    Effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer.
    J Int Med Res 2017 Feb 18;45(1):38-50. Epub 2016 Nov 18.
    1 Department of Internal Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Korea.
    Objective To investigate the cardiometabolic effects of a severe hypothyroid state induced by withdrawal of thyroid hormone replacement before radioactive iodine therapy. Methods Patients with thyroid cancer who were scheduled to receive radioactive iodine ablation were enrolled. Cardiometabolic parameters were measured using blood samples taken immediately before levothyroxine withdrawal, 4 weeks following withdrawal (on radiotherapy day), and 4 weeks following reinstitution of levothyroxine. Read More

    A rare case with synchronous gastric gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and uterine leiomyoma.
    World J Surg Oncol 2016 Nov 15;14(1):287. Epub 2016 Nov 15.
    Department of General and Hepato-pancreatic Surgery, University Hospital "Alexandrovska"-Sofia, 1 Georgi Sofiiski Str, 1431, Sofia, Bulgaria.
    Background: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. Read More

    Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.
    Int J Colorectal Dis 2017 Feb 4;32(2):273-280. Epub 2016 Nov 4.
    Clinic for Surgery, University Clinic Schleswig-Holstein, UKSH Campus Lübeck, 23538, Lübeck, Germany.
    Purpose: The aim of this study was to assess intraoperative, postoperative, and oncologic outcome in patients undergoing laparoscopic distal pancreatectomy (LDP) versus open distal pancreatectomy (ODP) for benign and malignant lesions of the pancreas.

    Methods: Data from patients undergoing distal pancreatic resection were extracted from the StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery. After propensity score case matching, groups of LDP and ODP were compared regarding demography, comorbidities, operative details, histopathology, and perioperative outcome. Read More

    Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma.
    J Cancer Res Clin Oncol 2016 Dec 14;142(12):2585-2591. Epub 2016 Sep 14.
    Department of Internal Medicine III, Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany.
    Purpose: Acinar cell carcinoma (ACC) of the pancreas is a very rare cancer, constituting 1 % of all malignant non-endocrine pancreatic tumors. Only very limited data exist to guide treatment in patients with advanced ACC.

    Methods: Between 2000 and 2015, 15 patients with ACC were diagnosed and/or treated at our high-volume comprehensive cancer center. Read More

    Clinical trials for BET inhibitors run ahead of the science.
    Drug Discov Today Technol 2016 Mar 21;19:45-50. Epub 2016 Jul 21.
    Department of Medicine, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address:
    Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4, one of the targets of these inhibitors, which is thought to cooperate with MYC, a long-desired target for cancer therapeutics. However, no current inhibitor is selective for BRD4 among the three somatic BET proteins, which include BRD2 and BRD3; their respective functions are partially overlapping and none are functionally redundant with BRD4. Read More

    Human exposure to endocrine disrupting compounds: Their role in reproductive systems, metabolic syndrome and breast cancer. A review.
    Environ Res 2016 Nov 7;151:251-264. Epub 2016 Aug 7.
    Water and Soil Quality Research Group, Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain; Catalan Institute for Water Research (ICRA), Parc Científic i Tecnològic de la Universitat de Girona, Emili Grahit 101, Edifici H2O, 17003 Girona, Spain. Electronic address:
    Endocrine disrupting chemicals (EDCs) are released into the environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDCs have major risks for humans by targeting different organs and systems in the body (e. Read More

    Antioxidation of Cerium Oxide Nanoparticles to Several Series of Oxidative Damage Related to Type II Diabetes Mellitus In Vitro.
    Med Sci Monit 2016 Oct 18;22:3792-3797. Epub 2016 Oct 18.
    Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin, China (mainland).
    BACKGROUND It is well known that cerium oxide nanoparticles (CeNPs) have intense antioxidant activity. The antioxidant property of CeNPs are widely used in different areas of research, but little is known about the oxidative damage of Cu2+ associated with Type II diabetes mellitus (T2DM). MATERIAL AND METHODS In our research, the function of CeNPs was tested for its protection of β-cells from the damage of Cu2+ or H2O2. Read More

    [Multiple Endocrine Neoplasia I (Wermers Syndrome), Forms of Clinical Manifestation, 5 Case Studies].
    Vnitr Lek Fall 2016;62(9 Suppl 3):140-149
    Multiple Endocrine Neoplasia (MEN) is a condition in which several endocrine organs of an individual are affected by adenoma, hyperplasia and less often carcinoma, either simultaneously or at different stages of life. Two existing syndromes, MEN1 and MEN2 (2A, 2B), in literature is also mentioned MEN4, are associated also with other non-endocrine disorders. MEN1 (Wermer syndrome) affects the pituitary, parathyroid, and pancreatic area. Read More

    Parenchyma-sparing surgery for pancreatic endocrine tumors.
    Updates Surg 2016 Sep 5;68(3):313-319. Epub 2016 Oct 5.
    Pancreatic Surgery Unit-Hospital Health Direction, Humanitas Research Hospital, Rozzano, MI, Italy.
    Enucleation (EN) and middle pancreatectomy (MP) have been proposed as a treatment for G1 and G2 pancreatic neuroendocrine tumors (PNET). The aim of this study is to analyze the outcomes of parenchyma-sparing surgery (PSS) for PNET in an Italian high-volume center. All patients with a histological diagnosis of PNET who underwent surgical resection in our center between January 2010 and January 2016 were included in the study. Read More

    The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models.
    Int J Mol Sci 2016 Sep 23;17(10). Epub 2016 Sep 23.
    Institut für Pathologie, Universitätsmedizin Greifswald, 17489 Greifswald, Germany.
    Activation of the epidermal growth factor receptor (EGFR) signaling pathway promotes the development of hepatocellular adenoma (HCA) and carcinoma (HCC). The selective EGFR inhibitor Gefitinib was found to prevent hepatocarcinogenesis in rat cirrhotic livers. Thus, Gefitinib might reduce progression of pre-neoplastic liver lesions to HCC. Read More

    Clinicopathological Features of Intraductal Papillary Mucinous Neoplasms of Pancreas in a Tertiary Care Center: A 14 Year Retrospective Study.
    J Clin Diagn Res 2016 Aug 1;10(8):EC10-3. Epub 2016 Aug 1.
    Assistant Professor, Department of Hepatopancreaticobiliary (HPB) Surgery, Christian Medical College Hospital , Vellore, Tamil Nadu, India .
    Introduction: Pancreatic surgeries are usually performed for inflammatory conditions and neoplasms. Intraductal Papillary Mucinous Neoplasm (IPMN) account for approximately 5-7% of all pancreatic neoplasms in western literature. To the best of our knowledge, there has been no published literature in Indian subcontinent on IPMN. Read More

    Comparison of postoperative early and late complications between pancreas-sparing duodenectomy and pancreatoduodenectomy.
    Surg Today 2017 Jun 21;47(6):705-711. Epub 2016 Sep 21.
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan.
    Purpose: Pancreas-sparing duodenectomy (PSD) represents an alternative procedure to pancreatoduodenectomy (PD) for patients with duodenal neoplasms.

    Methods: The postoperative early and late complications of 21 patients who underwent PSD between 1992 and 2014 were compared with those of 44 patients with soft pancreatic parenchyma who underwent PD between 2009 and 2014.

    Results: The median operation time and blood loss were less in the PSD group than in the PD group (P < 0. Read More

    Indications and results of pancreatic stump duct occlusion after duodenopancreatectomy.
    Updates Surg 2016 Sep 8;68(3):287-293. Epub 2016 Sep 8.
    Divisione di Chirurgia Digestiva, Fondazione Policlinico "A. Gemelli", Istituto di Clinica Chirurgica, Rome, Italy.
    Severe post-operative complications after pancreaticoduodenectomy (PD) are largely due to pancreatic fistula onset. The occlusion of the main pancreatic duct using synthetic glue may prevent these complications. Aim of this study is to describe this technique and to report short- and long-term results as well as the post-operative endocrine and exocrine insufficiency. Read More

    Survival variability of controls and definition of imaging endpoints for longitudinal follow-up of pancreatic ductal adenocarcinoma in rats.
    J Cancer Res Clin Oncol 2017 Jan 12;143(1):29-34. Epub 2016 Sep 12.
    IRCAD, University Hospital of Strasbourg, 1 place de l'hôpital, Strasbourg, France.
    Background: The 3Rs guideline is the gold standard for ethics in animal experimentation. Two of those rules, namely refinement and reduction, require further improvement. The objective of this study was to define pathways to better compliance with these prerequisites. Read More

    Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors.
    Minerva Endocrinol 2016 Dec;41(4):490-8
    Department of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy -
    Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum. Read More

    Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through Autophagy and EDC3 Protein in Insulinoma INS-1E Cells.
    Oxid Med Cell Longev 2016 17;2016:2594703. Epub 2016 Jul 17.
    Department of Biomedical Engineering, Yonsei-Fraunhofer Medical Device Laboratory, Yonsei University, Wonju, Gangwon-do 26493, Republic of Korea.
    2-DG triggers glucose deprivation without altering other nutrients or metabolic pathways and then activates autophagy via activation of AMPK and endoplasmic reticulum (ER) stress. We investigated whether 2-DG reduced intracellular insulin increased by melatonin via autophagy/EDC3 in insulinoma INS-1E cells. p-AMPK and GRP78/BiP level were significantly increased by 2-DG in the presence/absence of melatonin, but IRE1α level was reduced in 2-DG treatment. Read More

    18F-DOPA PET/CT Physiological Distribution and Pitfalls: Experience in 215 Patients.
    Clin Nucl Med 2016 Oct;41(10):753-60
    From the *Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, IBFM-CNR, Italian National Research Council, Catanzaro; †Department of Biomedicine and Prevention, University "Tor Vergata," Rome; ‡Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila; Departments of §Neuroendocrinology, and ∥Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli, Isernia; ¶Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome, and IRCCS Neuromed, Pozzilli (IS), Italy; and **Department of Nuclear Medicine, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
    Purpose: F-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-DOPA uptake.

    Patients And Methods: We examined 215 patients with F-DOPA PET/CT. Read More

    Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1.
    J Endocrinol 2016 Sep 18;230(3):347-55. Epub 2016 Jul 18.
    Department of Basic Medical SciencesMedical College, Xiamen University, Xiamen, China
    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited syndrome characterized by multiple tumors in the parathyroid glands, endocrine pancreas and anterior pituitary. Recent clinical studies have revealed a strong association between MEN1 syndrome and the risk of developing diabetes mellitus; however, the underlying mechanisms remain unknown. In this study, heterozygous Men1 knockout (Men1(+/-)) mice were used as MEN1 models to investigate MEN1-associated glucose metabolic phenotypes and mechanisms. Read More

    Short- and long-term outcomes after enucleation of pancreatic tumors: An evidence-based assessment.
    Pancreatology 2016 Nov - Dec;16(6):1092-1098. Epub 2016 Jul 9.
    Department of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China.
    Background And Objective: Enucleation of pancreatic tumors is rarely performed. The aim of this study was to evaluate the published evidence for its short- and long-term outcomes.

    Methods: PubMed (MEDLINE) and EMBASE databases were searched from 1990 to March 2016. Read More

    Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
    Hosp Pract (1995) 2016 Aug 18;44(3):109-19. Epub 2016 Jul 18.
    a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.
    Pancreatic neuroendocrine tumors (PNETs) are neoplasms that arise from the hormone producing cells of the islets of Langerhans, also known as pancreatic islet cells. PNETs are considered a subgroup of neuroendocrine tumors, and have unique biology, natural history and clinical management. These tumors are classified as 'functional' or 'non-functional' depending on whether they release peptide hormones that produce specific hormone- related symptoms, usually in established patterns based on tumor subtype. Read More

    Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.
    Pancreas 2016 08;45(7):e37-9
    Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan Department of Surgery Tsuru Municipal Hospital Tsuru, Japan Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan Department of Medical Oncology Shinko Hospital Kobe, Japan Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan.

    CD4(+) T cell-dominant insulitis in acute-onset Type 1 diabetes mellitus associated with intraductal papillary mucinous adenoma.
    Endocr J 2016 Sep 5;63(9):841-847. Epub 2016 Jul 5.
    Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tachikawa 190-8531, Japan.
    The loss of insulin-producing pancreatic β-cells in Type 1 diabetes mellitus (DM) is presumably the result of a T cell-mediated process. In general, CD8(+) T cells are the predominant lymphocytes in the insulitis lesions, and CD4(+) T cell-dominant insulitis is very rare. We present a case of a 72-year-old woman presented with excessive thirst and a 3-month history of weight loss. Read More

    Intraoperative portal vein insulin assay combined with occlusion of the pancreas for complex pancreatogenous hypoglycemia: Two cases report.
    Medicine (Baltimore) 2016 Jun;95(26):e3928
    Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.
    Intraoperative localization and confirmation of complete resection of the hypersecreting tissue are the 2 main challenges in the management of pancreatogenous hypoglycemia. Here, we report our experience with intraoperative portal vein insulin assay combined with occlusion of the pancreas in the management of pancreatogenous hypoglycemia. Clinical courses of 2 patients with biochemical evidence of a pancreatogenous hypoglycemia were studied. Read More

    The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report.
    Hiroshima J Med Sci 2016 Mar;65(1):13-7
    The localization and diagnosis of microgastrinomas in a patient with multiple endocrine neoplasia type 1 is difficult preoperatively. The selective arterial calcium injection (SACI) test is a valid diagnostic method for the preoperative diagnosis of these invisible microgastrinomas. We report a rare case of multiple invisible duodenal microgastrinomas with severe duodenal stenosis diagnosed preoperatively by using the SACI test. Read More

    Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response.
    Biochim Biophys Acta 2016 09 22;1861(9 Pt A):1151-60. Epub 2016 Jun 22.
    Department of Medical Cell Biology, Uppsala University, Box 571, 75123 Uppsala, Sweden.
    Long-term exposure of beta cells to saturated fatty acids impairs insulin secretion and increases apoptosis. In contrast, unsaturated fatty acids protect beta-cells from the long-term negative effects of saturated fatty acids. We aimed to identify the mechanisms underlying this protective action of unsaturated fatty acids. Read More

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