5,597 results match your criteria Neoplasms of the Endocrine Pancreas


Epidemiology of pancreatic neuroendocrine neoplasms: a gender perspective.

Endocrine 2020 May 28. Epub 2020 May 28.

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Purpose: Pancreatic neuroendocrine neoplasms (PNENs) are a group of clinically rare and heterogeneous tumors of the pancreas. Currently there are no studies investigating the gender difference in PNEN susceptibility. Thus, the purpose of this study was aimed at examining how gender shapes risk factors, clinicopathological features, and comorbidities in PNENs. Read More

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http://dx.doi.org/10.1007/s12020-020-02331-3DOI Listing

Progesteron receptor expression in insulin producing cells of neuroendocrine neoplasms.

J Steroid Biochem Mol Biol 2020 May 11;201:105694. Epub 2020 May 11.

Department of Pathology, Tohoku University Graduate School of Medicine, Miyagi, Japan.

Progesterone receptor (PgR) inhibits cell proliferation in pancreatic neuroendocrine neoplasms (PanNEN). In non-neoplastic pancreas, loss of PgR induces β-cell proliferation and insulin production. However, detailed association between PgR and insulin producing PanNENs is poorly understood. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105694DOI Listing

Study Protocol of the ESAP Study: Endoscopic Papillectomy vs. Surgical Ampullectomy vs. Pancreaticoduodenectomy for Ampullary Neoplasm-A Pancreas2000/EPC Study.

Front Med (Lausanne) 2020 6;7:152. Epub 2020 May 6.

Department of Digestive, Hepatobiliary and Endocrine Surgery, Paris Descartes University, Cochin Hospital, Paris, France.

Lesions of the Ampulla of Vater are a rare condition and represent <10% of peri-ampullary neoplasms. Nevertheless, ampullary adenomas have the potential for malignant transformation to ampullary carcinomas by an adenoma-to-carcinoma sequence. Thus, adequate patient selection and complete resection (R0) of non-invasive ampullary lesions either by endoscopic papillectomy (EP), surgical ampullectomy (SA), or pancreaticoduodenectomy (PD) is essential. Read More

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http://dx.doi.org/10.3389/fmed.2020.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218136PMC

Serotonin-Secreting Neuroendocrine Tumours of the Pancreas.

J Clin Med 2020 May 6;9(5). Epub 2020 May 6.

Pancreatic and Endocrine Digestive Surgical Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, via Giustiniani, 2-35128 Padua, Italy.

Background: Serotonin-secreting pancreatic neuroendocrine tumours (5-HT-secreting pNETs) are very rare, and characterised by high urinary 5-hydroxyindole-acetic acid (5-HIAA) levels (or high serum 5-HT levels).

Methods: Patients with 5-HT-secreting pancreatic neoplasms observed in our unit (1986-2015) were included. Diagnosis was based on urinary 5-HIAA or serum 5-HT levels. Read More

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http://dx.doi.org/10.3390/jcm9051363DOI Listing

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.

PLoS One 2020 16;15(3):e0224344. Epub 2020 Mar 16.

Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America.

A key event in the development of both major forms of diabetes is the loss of functional pancreatic islet β-cell mass. Strategies aimed at enhancing β-cell regeneration have long been pursued, but methods for reliably inducing human β-cell proliferation with full retention of key functions such as glucose-stimulated insulin secretion (GSIS) are still very limited. We have previously reported that overexpression of the homeobox transcription factor NKX6. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224344PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075568PMC

[A Case of Borderline Resectable Pancreatic Adenosquamous Carcinoma Achieving Pathological Complete Response].

Gan To Kagaku Ryoho 2019 Dec;46(13):2425-2427

Dept. of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine.

The patient was a 66-year-old man presenting with epigastric pain and jaundice. PET-CT demonstrated limited-accumulation on the tumor at the head of the pancreas, diagnosed as borderline resectable adenosquamous carcinoma. The patient was treated with preoperative chemoradiation therapy with 2 courses of gemcitabine followed by administration of S-1 and gemcitabine for 13 months, which reduced the tumor size. Read More

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December 2019

Disease-free survival as a measure of overall survival in resected pancreatic endocrine neoplasms.

Endocr Relat Cancer 2020 03 10;27(5):275-283. Epub 2020 Mar 10.

Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute, Milan, Italy

Overall survival (OS) is considered as the standard measure of outcome in oncology. However, considering that resectable pancreatic neuroendocrine neoplasms (Pan-NENs) usually have a long OS, the feasibility of prospective studies is questionable due to a long follow-up period needed. The primary endpoint was to validate the use of disease-free survival (DFS) as a surrogate measure of OS. Read More

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http://dx.doi.org/10.1530/ERC-19-0468DOI Listing

[Inherited tumor syndromes of gastroenteropancreatic and thoracic neuroendocrine neoplasms].

Ann Pathol 2020 Apr 5;40(2):120-133. Epub 2020 Feb 5.

Département de biologie et pathologie médicales, institut Gustave-Roussy, 114, rue Edouard-Vaillant, 94805 Villejuif cedex, France. Electronic address:

About 5% of gastroenteropancreatic and thoracic neuroendocrine neoplasms (NENs) arise in the context of an inherited tumour syndrome. The two most frequent syndromes are: multiple endocrine neoplasia type 1 (MEN1), associated with a large spectrum of endocrine and non endocrine tumours, including duodenopancreatic, thymic and bronchial NENs, and the von Hippel-Lindau syndrome VHL, associated with pancreatic NENs. Two inherited syndromes have a low incidence of NENs: neurofibromatosis type 1 (NF1), associated with duodenal somatostatinomas, and tuberous sclerosis (TSC), associated with pancreatic NENs. Read More

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http://dx.doi.org/10.1016/j.annpat.2020.01.002DOI Listing

Prevalence of Syndecan-1 (CD138) Expression in Different Kinds of Human Tumors and Normal Tissues.

Dis Markers 2019 23;2019:4928315. Epub 2019 Dec 23.

Institute of Pathology, Jakob-Henle-Straße 1 90766 Fürth, Germany.

Syndecan-1 (CD138) is a transmembrane proteoglycan known to be expressed in various normal and malignant tissues. It is of interest because of a possible prognostic role of differential expression in tumors and its role as a target for indatuximab, a monoclonal antibody coupled with a cytotoxic agent. To comprehensively analyze CD138 in normal and neoplastic tissues, we used tissue microarrays (TMAs) for analyzing immunohistochemically detectable CD138 expression in 2,518 tissue samples from 85 different tumor entities and 76 different normal tissue types. Read More

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http://dx.doi.org/10.1155/2019/4928315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954471PMC
May 2020
2.174 Impact Factor

Surgical Management of Solid Pseudopapillary Neoplasms of Pancreas: A Single-Center Experience of 60 Patients.

Dig Surg 2020 Jan 20:1-7. Epub 2020 Jan 20.

Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China,

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare neoplasms, and the selection of surgical approaches is still under debate. The aim of this study was to analyze the clinicopathological characteristics and surgical outcomes of SPN patients and to compare the short-term and long-term outcomes between conventional operations and parenchyma-preserving operations.

Methods: Patients who underwent pancreatic resection for SPNs between February 2010 and May 2019 in Fujian Medical University Union Hospital were identified. Read More

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http://dx.doi.org/10.1159/000505062DOI Listing
January 2020

Long noncoding RNA-mRNA expression profiles and validation in pancreatic neuroendocrine neoplasms.

Clin Endocrinol (Oxf) 2020 Apr 25;92(4):312-322. Epub 2020 Jan 25.

Department of General Surgery (Department of Pancreatic-biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China.

Background: Pancreatic neuroendocrine neoplasms (pNENs) are a group of endocrine tumours arising in the pancreas and deemed to be the most common neuroendocrine tumours. The pathogenesis of pNENs remains unknown. Long noncoding RNAs (lncRNAs) are aberrantly expressed in cancers. Read More

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http://dx.doi.org/10.1111/cen.14156DOI Listing

Irp2 regulates insulin production through iron-mediated Cdkal1-catalyzed tRNA modification.

Nat Commun 2020 01 15;11(1):296. Epub 2020 Jan 15.

Department of Medicine, Division of Hematology, University of Utah, Salt Lake City, UT, 84112, USA.

Regulation of cellular iron homeostasis is crucial as both iron excess and deficiency cause hematological and neurodegenerative diseases. Here we show that mice lacking iron-regulatory protein 2 (Irp2), a regulator of cellular iron homeostasis, develop diabetes. Irp2 post-transcriptionally regulates the iron-uptake protein transferrin receptor 1 (TfR1) and the iron-storage protein ferritin, and dysregulation of these proteins due to Irp2 loss causes functional iron deficiency in β cells. Read More

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http://dx.doi.org/10.1038/s41467-019-14004-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962211PMC
January 2020

A Rare Case of Insulinoma: A Case Report.

Mymensingh Med J 2020 Jan;29(1):222-227

Professor Md Mohsen Chowdhury, Professor & Head of Yellow Unit II, Department of Hepatobiliary & Pancreatic Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh; E-mail:

Insulinoma is a rare variety of endocrine neoplasm and is usually benign, solitary, and small in size. The hallmark of this disorder is high endogenous insulin secretion resulting in development of symptoms of hypoglycemia. Insulinomas account for 60% of islet cell tumors (ICT) of the pancreas. Read More

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January 2020

Central Pancreatectomy Versus Distal Pancreatectomy and Pancreaticoduodenectomy for Benign and Low-Grade Malignant Neoplasms: A Retrospective and Propensity Score-Matched Study with Long-Term Functional Outcomes and Pancreas Volumetry.

Ann Surg Oncol 2020 Apr 2;27(4):1215-1224. Epub 2020 Jan 2.

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: It remains controversial whether central pancreatectomy (CP) can preserve the exocrine and endocrine function of the pancreas or not. This study aimed to evaluate the safety and efficacy of CP compared with distal pancreatectomy (DP) and pancreaticoduodenectomy (PD) for benign and low-grade malignant neoplasms.

Methods: This retrospective study enrolled 219 patients who underwent elective CP (n = 55), DP (n = 70), or PD (n = 94) for benign and low-malignant neoplasms in a single university hospital between January 2000 and December 2015. Read More

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http://dx.doi.org/10.1245/s10434-019-08095-zDOI Listing

Gastrinoma in multiple endocrine neoplasia type 1 after total pancreatectomy: A case report.

Medicine (Baltimore) 2019 Dec;98(50):e18275

Outpatient Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Rationale: Surgery for patients with multiple endocrine neoplasia type 1(MEN-1) related gastrinoma remains controversial and total pancreatectomy (TP) has rarely been performed. We reported a case of patient with MEN-1 related gastrinoma treated by TP.

Patient Concerns: A 46-year-old female was admitted to our hospital due to abdominal distension and diarrhea for 2 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000018275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922403PMC
December 2019

Treatment Patterns and Survival among Patients with Metastatic Gastroenteropancreatic Neuroendocrine Tumours in Sweden - a Population-based Register-linkage and Medical Chart Review Study.

J Cancer 2019 17;10(27):6876-6887. Epub 2019 Nov 17.

Former employee at Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are neoplasms derived from the endocrine system in the gastrointestinal tract and pancreas. Treatment options include surgery; pharmacological treatments like somatostatin analogues (SSA), interferon alpha, molecular targeted therapy and chemotherapy; and peptide receptor radionuclide therapy. The objective of this study was to describe treatment patterns and survival among patients with metastatic GEP-NET grade 1 or 2 in Sweden. Read More

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http://dx.doi.org/10.7150/jca.32381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909946PMC
November 2019
2.639 Impact Factor

Surgical management of pancreatic neuroendocrine tumors: an introduction.

Expert Rev Anticancer Ther 2019 12 17;19(12):1089-1100. Epub 2019 Dec 17.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Cochin Hospital, APHP, Paris, France.

: Neuroendocrine tumors of the pancreas (pNETs) represent only 1% to 2% of all pancreatic neoplasms. These tumors can be classified as functional or nonfunctional tumors; as sporadic or from a genetic origin; as neuroendocrine neoplasms or carcinoma. Over the last decade, diagnosis of pNETs has increased significantly mainly due to the widespread use of cross-sectional imaging. Read More

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http://dx.doi.org/10.1080/14737140.2019.1703677DOI Listing
December 2019
5 Reads

PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo.

Lipids Health Dis 2019 Dec 10;18(1):214. Epub 2019 Dec 10.

BioScience Research Centre and Department of Medicine, Gayatri Vidya Parishad Hospital, GVP College of Engineering Campus, Visakhapatnam, 530048, India.

Objective: To study whether minimal doses of arachidonic acid (AA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and lipoxin A4 (LXA4) and brain-derived neurotrophic factor (BDNF), when used in combination can protect RIN5F cells from chemical-induced cytotoxicity. As a corollary, to know whether plasma BDNF and LXA4 are altered in STZ-induced type 2 DM animals.

Materials And Methods: RIN5F cells, alloxan (AL), streptozotocin (STZ), doxorubicin (DB), and benzo(a)pyrene (BP) were used in this study. Read More

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http://dx.doi.org/10.1186/s12944-019-1164-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159172PMC
December 2019

The Role of PET/CT in the Imaging of Pancreatic Neoplasms.

Semin Ultrasound CT MR 2019 Dec 25;40(6):500-508. Epub 2019 Apr 25.

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, Stanford, CA. Electronic address:

Pancreas cancer is a complex disease and its prognosis is related to the origin of the tumor cell as well as the stage of disease at the time of diagnosis. Pancreatic adenocarcinomas derive from the exocrine pancreas and are the fourth leading cause of cancer-related deaths in the United States, while well-differentiated pancreatic neuroendocrine tumors (pNETs) derived from the endocrine part of the pancreas are rare and characterized by a slow growth and good life expectancy. Surgery is the only curative treatment approach, and an accurate assessment of resectability is of paramount importance in order to avoid futile procedures. Read More

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http://dx.doi.org/10.1053/j.sult.2019.04.006DOI Listing
December 2019

Central Distal Pancreatectomy for Benign or Low-Grade Malignant Lesions in the Pancreatic Neck and Proximal Body.

Authors:
Yangjun Li Yujie Li

Am Surg 2019 Nov;85(11):1239-1245

The purpose of this meta-analysis was to compare the clinical outcomes of central pancreatectomy (CP) with distal pancreatectomy (DP). PubMed, Web of Knowledge, and Ovid's database were searched for studies published in English language between January 1990 and December 2018. A meta-analysis was performed to compare the clinical outcomes of CP DP. Read More

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November 2019

Diabetes and cancer: A comprehensive review.

Authors:
Manal Abudawood

J Res Med Sci 2019 25;24:94. Epub 2019 Oct 25.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, KSA.

Diabetes mellitus (DM) is a common worldwide endocrine disorder characterized by hyperglycemia resulting from defects in insulin secretion and insulin action or both. A number of clinical studies have investigated diabetes and its causal relation with neoplasm. Several epidemiological studies have found that diabetic patients have an increased risk of different types of cancers, for example liver, pancreas, gastric (stomach), colorectum, kidney, and breast, and it is predicted that hyperglycemic state observed in diabetic milieu enhances the cancer risk in prediabetic and diabetic individuals. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_242_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856544PMC
October 2019

Long-Term Assessment of Pancreatic Function After Pancreatectomy for Cystic Neoplasms.

J Surg Res 2020 03 15;247:547-555. Epub 2019 Nov 15.

Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas. Electronic address:

Background: With advances in cross-sectional imaging, pancreatic cysts are more frequently diagnosed and have become a common indication for pancreatectomy. The impact of pancreatectomy in these patients is important. The purpose of this study was to assess short-term outcomes, long-term nutritional status, quality of life (QOL), and pancreas function after pancreatectomy for cystic neoplasms. Read More

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http://dx.doi.org/10.1016/j.jss.2019.09.045DOI Listing

Orbital metastases from neuroendocrine neoplasms: clinical implications and outcomes.

Endocrine 2020 Feb 15;67(2):485-493. Epub 2019 Nov 15.

Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

Purpose: Neuroendocrine neoplasms (NENs) may rarely metastasise to the orbit. Published data on epidemiology, incidence and preferred treatment is limited. We present the largest cohort of symptomatic and asymptomatic NEN patients with orbital metastases and data on epidemiological parameters, symptoms as well as diagnostic/treatment modalities used. Read More

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http://dx.doi.org/10.1007/s12020-019-02130-5DOI Listing
February 2020

Atypical ovarian carcinoid tumor with widespread skeletal metastases: a case report of multiple endocrine neoplasia type 1 in a young woman.

BMC Cancer 2019 Nov 14;19(1):1107. Epub 2019 Nov 14.

Department of Pathology, The Second Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, 050000, People's Republic of China.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant inherited condition affecting multiple endocrine organs, resulting in significant morbidity and decreased life expectancy. Early tumor identification allows for timely patient management, reduces morbidity, and improves disease outcomes. Patients with MEN1 typically present with primary hyperparathyroidism caused by multiple parathyroid tumors, however, thymic and bronchial carcinoid tumors are also less common manifestations. Read More

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http://dx.doi.org/10.1186/s12885-019-6332-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857273PMC
November 2019

[Gastroenteropancreatic neuroendocrine tumor microenvironment and related therapy].

Zhonghua Wai Ke Za Zhi 2019 Nov;57(11):866-871

Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.

Neuroendocrine tumor(NET) is a kind of highly heterogeneous and ubiquitous tumor, frequently localized in the gastrointestinal tract and pancreas. Surgery combined with regional ablation, endocrine therapy,chemotherapy and targeted therapy presents a favorable prognosis when treated with G1 or G2 gastroenteropancreatic neuroendocrine tumor(GEP-NET). However, there are only limited therapeutic strategies for metastatic unresectable tumors and poorly differentiated NEC,which are closely related to the special tumor microenvironment of neuroendocrine tumors. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.11.014DOI Listing
November 2019
1 Read

[Multiple endocrine neoplasia type 1: about a case].

Pan Afr Med J 2019 19;33:238. Epub 2019 Jul 19.

Service d'Endocrinologie, Diabétologie et Maladies Métaboliques, CHU Mohamed VI Marrakech, Maroc.

Multiple endocrine neoplasia type 1 (MEN1) is a rare disease, defined as a tumor developing in at least two endocrine glands including the anterior pituitary gland, the parathyroid glands and the duodenopancreatic endocrine tissue. This disorder, inherited in an autosomal dominant pattern, is caused by mutations in the MEN1 gene encoding the tumor suppressor menin and located on chromosome 11q13. However, sporadic cases account for 8-14%. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.238.18053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814935PMC
November 2019
1 Read

Burkitt's Lymphoma Involving Multiple Hormone-Producing Organs on FDG PET/CT.

Clin Nucl Med 2019 Dec;44(12):995-997

Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Lymphoma involving many different organs can be occasionally observed. However, lymphoma involvement of multiple hormone-producing organs is rare. In this report, we described our FDG PET/CT findings in a 21-year-old man whose Burkitt's lymphoma involved not only lymph nodes, the spleen, the brain, and the bones, but also 4 organs in the endocrine system, including the thyroid, right adrenal, the pancreas, and the right testicle. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002807DOI Listing
December 2019

Intravital imaging of vascular anomalies and extracellular matrix remodeling in orthotopic pancreatic tumors.

Int J Cancer 2020 04 23;146(8):2209-2217. Epub 2019 Nov 23.

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Pancreatic cancers, both adenocarcinomas and endocrine tumors are characterized by varying levels of aberrant angiogenesis and fibrotic microenvironment. The difficulty to deliver drugs and treat the disease has been attributed in part to the vascular architecture and tissue/ECM density. Here we present longitudinal three-dimensional intravital imaging of vascular and tumor microenvironment remodeling in spontaneous transgenic tumors (RIP1-Tag2 insulinomas) and orthotopically injected tumors (KPC adenocarcinomas). Read More

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http://dx.doi.org/10.1002/ijc.32759DOI Listing

La néoplasie endocrinienne multiple de type 1 : mise au point après le congrès de l’ENETS 2019: Multiple Endocrine Neoplasia Type 1: Development after the ENETS 2019 Congress.

Ann Endocrinol (Paris) 2019 Sep;80 Suppl 1:S19-S28

Service endocrinologie et maladies métaboliques, pôle cardio-vasculaire et métabolique, CHU Larrey-Rangueil, Toulouse, France.

Multiple Endocrine Neoplasia Type 1 (NEM1) is related to mutations of the menin gene. It is an autosomal dominant disease. Its prevalence is about 1/30 000 with a hugh penetrance. Read More

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http://dx.doi.org/10.1016/S0003-4266(19)30113-1DOI Listing
September 2019
1 Read

Pancreatoblastoma: Cytologic and histologic analysis of 12 adult cases reveals helpful criteria in their diagnosis and distinction from common mimics.

Cancer Cytopathol 2019 Nov 3;127(11):708-719. Epub 2019 Oct 3.

Department of Pathology, Koç University Hospital, Istanbul, Turkey.

Background: Pancreatoblastoma (PBL) is a rare malignant pancreatic tumor seen predominantly in childhood, and its cytologic diagnosis remains challenging.

Methods: Twelve fine-needle-aspirations from 11 adults were analyzed.

Results: In total, 6 men and 5 women (median age, 45 years; age range, 32-60 years) had tumors measuring a median 5. Read More

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http://dx.doi.org/10.1002/cncy.22187DOI Listing
November 2019
1 Read

Impact of tumor size and nodal status on recurrence of nonfunctional pancreatic neuroendocrine tumors ≤2 cm after curative resection: A multi-institutional study of 392 cases.

J Surg Oncol 2019 Dec 30;120(7):1071-1079. Epub 2019 Sep 30.

Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: The current study sought to define the impact of lymph node metastasis (LNM) relative to tumor size on tumor recurrence after curative resection for nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) ≤2 cm.

Methods: Patients who underwent curative resection for ≤2-cm NF-pNETs were identified from a multi-institutional database. Risk factors associated with tumor recurrence as well as LNM were identified. Read More

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http://dx.doi.org/10.1002/jso.25716DOI Listing
December 2019
3 Reads

CT- and MRI-Based Assessment of Body Composition and Pancreatic Fibrosis Reveals High Incidence of Clinically Significant Metabolic Changes That Affect the Quality of Life and Treatment Outcomes of Patients with Chronic Pancreatitis and Pancreatic Cancer.

Medicina (Kaunas) 2019 Sep 27;55(10). Epub 2019 Sep 27.

Institute for Digestive System Research, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania.

Both chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) may lead to cachexia, sarcopenia, and osteoporosis due to different mechanisms. Neither patient gender, age, nor body weight are good predictors of these metabolic changes having a significant negative impact on the quality of life (QOL) and treatment outcomes. The aim of this study was to evaluate radiological changes in body composition and to compare them with manifestations of exocrine and endocrine pancreatic insufficiency, body mass, and QOL among patients with CP and PDAC. Read More

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http://dx.doi.org/10.3390/medicina55100649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843405PMC
September 2019
1 Read

Neuroendocrine Neoplasms of the Small Bowel and Pancreas.

Neuroendocrinology 2020 27;110(6):444-476. Epub 2019 Sep 27.

Department of Surgery and Cancer, Imperial College London, London, United Kingdom,

The traditionally promulgated perspectives of neuroendocrine neoplasms (NEN) as rare, indolent tumours are blunt and have been outdated for the last 2 decades. Clear increments in their incidence over the past decades render them increasingly clinically relevant, and at initial diagnosis many present with nodal and/or distant metastases (notably hepatic). The molecular pathogenesis of these tumours is increasingly yet incompletely understood. Read More

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http://dx.doi.org/10.1159/000503721DOI Listing
September 2019
3 Reads

Predictors of antiproliferative effect of lanreotide autogel in advanced gastroenteropancreatic neuroendocrine neoplasms.

Endocrine 2020 Jan 25;67(1):233-242. Epub 2019 Sep 25.

Centre for Gastroenterology, Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation Trust, London, UK.

Purpose: The antiproliferative properties of lanreotide autogel (LAN) in gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) were demonstrated in the CLARINET study. However, there is limited literature regarding factors that affect progression-free survival (PFS) in patients with GEP NENs treated with LAN.

Methods: We identified a total of 191 treatment-naive patients with advanced GEP NENs and positive SSTR uptake on imaging (Octreoscan or Gallium DOTATATE Positron Emission Tomography [GaPET]) who received first-line LAN monotherapy, albeit at various starting doses (60, 90 or 120 mg/month). Read More

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http://dx.doi.org/10.1007/s12020-019-02086-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968981PMC
January 2020
2 Reads

Operative resection in early stage pancreatic neuroendocrine tumors in the United States: Are we over- or undertreating patients?

Surgery 2020 01 16;167(1):180-186. Epub 2019 Sep 16.

Department of Surgery, Division of General Surgery and Surgical Oncology, Endocrine Surgery Research Program, The University of Chicago Medicine, IL. Electronic address:

Background: Many current guidelines recommend nonoperative management for pancreatic neuroendocrine tumors <2 cm. The objective of this study was to evaluate the utilization and outcomes of resection for these pancreatic neuroendocrine tumors in the United States.

Methods: Using the National Cancer Database (2004-2014), 3,243 cases of T1 (≤2. Read More

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http://dx.doi.org/10.1016/j.surg.2019.04.061DOI Listing
January 2020
1 Read

Surgical management of Zollinger-Ellison syndrome: Classical considerations and current controversies.

World J Gastroenterol 2019 Aug;25(32):4673-4681

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100730, China.

Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion causing severe recurrent acid-related peptic disease. Excessive secretion of gastrin can now be effectively controlled with powerful proton pump inhibitors, but surgical management to control gastrinoma itself remains controversial. Based on a thorough literature review, we design a surgical algorithm for ZES and list some significant consensus findings and recommendations: (1) For sporadic ZES, surgery should be routinely undertaken as early as possible not only for patients with a precisely localized diagnosis but also for those with negative imaging findings. Read More

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http://dx.doi.org/10.3748/wjg.v25.i32.4673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718045PMC
August 2019
4 Reads

deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells.

Proc Natl Acad Sci U S A 2019 10 16;116(40):19983-19988. Epub 2019 Sep 16.

Molecular Diabetology, Paul Langerhans Institute Dresden (PLID) of the Helmholtz German Center for Diabetes Research (DZD e.V.) Munich, University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, 01307 Dresden, Germany.

Pancreatic β cells store insulin within secretory granules which undergo exocytosis upon elevation of blood glucose levels. Crinophagy and autophagy are instead responsible to deliver damaged or old granules to acidic lysosomes for intracellular degradation. However, excessive consumption of insulin granules can impair β cell function and cause diabetes. Read More

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http://dx.doi.org/10.1073/pnas.1903678116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778207PMC
October 2019
2 Reads

68Ga-DOTATATE: Significance of Uptake in the Tail of the Pancreas in Patients Without Lesions.

Clin Nucl Med 2019 Nov;44(11):851-854

From the Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center.

Purpose: To measure the SUVs in the tail of the pancreas compared with normal liver parenchyma and somatostatin receptor-positive lesions.

Materials And Methods: Ga-DOTATATE PET/low mAs CT of 35 patients were reviewed.

Results: There was no significant difference (P = 0. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002757DOI Listing
November 2019
1 Read

Contemporary surgical management of the Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1.

Best Pract Res Clin Endocrinol Metab 2019 10 31;33(5):101318. Epub 2019 Aug 31.

Department of Visceral, Thoracic, and Vascular Surgery, Philipps University Marburg, Baldingerstr, 35037 Marburg, Germany.

About 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphatic metastases, the survival is generally good with an aggressive course of disease in only about 20% of patients. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101318DOI Listing
October 2019
2 Reads

Unmet needs in the international neuroendocrine tumor (NET) community: Assessment of major gaps from the perspective of patients, patient advocates and NET health care professionals.

Int J Cancer 2020 03 25;146(5):1316-1323. Epub 2019 Oct 25.

Neuroendocrine Tumor Research Foundation (NETRF), Boston, MA.

Due to the increasing incidence and prevalence of neuroendocrine tumors (NETs), there is a need to assess any gaps in awareness and care. A survey was undertaken in 2017 to identify perceived unmet needs from the perspectives of patients/families, patient advocates and health care professionals (HCPs). The survey consisted of 33-37 questions (depending on type of respondent) across four areas: information, care, treatments and research. Read More

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http://dx.doi.org/10.1002/ijc.32678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004101PMC

Pancreatic Polypeptide-Secreting Tumour of the Proximal Pancreas (PPoma)-Ultra Rare Pancreatic Tumour: Clinically Malign, Histologically Benign.

Medicina (Kaunas) 2019 Aug 23;55(9). Epub 2019 Aug 23.

Medical Faculty of Niš, University of Niš, 18000 Niš, Serbia.

Here we report a rare case of a pancreatic polypeptide-secreting tumour (PPoma) discovered by accident during an autopsy. These PPomas occur in less than 2% of all pancreatic neoplasms and are almost exclusively silent, i.e. Read More

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http://dx.doi.org/10.3390/medicina55090523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780158PMC
August 2019
2 Reads

A rational approach to postoperative surveillance for resected non-functional pancreatic neuro-endocrine tumours.

Pancreatology 2019 Oct 16;19(7):1000-1007. Epub 2019 Aug 16.

Department of Hepatobiliary Surgery, Hepatopancreatobiliary (HPB) Surgical Unit, Addenbrooke's Hospital, Cambridge, UK. Electronic address:

Background: Non-functional pancreatic neuroendocrine tumours (NF-PNETs) are rare and have highly variable outcomes. Current guidelines recommend surveillance for NF-PNETs <2 cm. Patients who ultimately have surgical resection are at risk of disease recurrence, and data to support postoperative surveillance protocols are lacking. Read More

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http://dx.doi.org/10.1016/j.pan.2019.08.005DOI Listing
October 2019

A rare case of rectal cancer with perianal metastasis: a case report.

World J Surg Oncol 2019 Aug 20;17(1):149. Epub 2019 Aug 20.

Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, City, Miyazaki, Japan.

Background: Cancer metastasis from colon cancer to an anal fistula is very rare. We herein reported a rare case in which local excision was performed for metastatic anal fistula cancer originating from rectal cancer.

Case Presentation: A 68-year-old man was referred to our institution with a diagnosis of rectal cancer. Read More

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http://dx.doi.org/10.1186/s12957-019-1692-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700774PMC
August 2019
4 Reads

The ENETS TNM staging and grading system accurately predict prognosis in patients with rectal NENs.

Dig Liver Dis 2019 12 9;51(12):1725-1730. Epub 2019 Aug 9.

University Denis Diderot - Paris VII, Paris, France; Department of Gastroenterology and Pancreatology, Beaujon Hospital, APHP, ENETs Center of Excellence, Clichy, France.

Background: Factors associated with rectal NENs prognosis are poorly investigated.

Aim: To evaluate the prognostic role of the ENETs staging and grading systems in rectal NENs.

Methods: Tertiary referral, multicenter, retrospective study. Read More

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http://dx.doi.org/10.1016/j.dld.2019.07.011DOI Listing
December 2019
1 Read

Avoiding Pitfalls in Insulinomas by Preoperative Localization with a Dual Imaging Approach.

Am Surg 2019 Jul;85(7):742-746

Insulinomas are rare endocrine malignancies of the pancreas that require surgical resection but can be difficult to localize preoperatively. We sought to review and improve the accuracy of preoperative localization techniques at our institution. We retrospectively reviewed all insulinomas that underwent resection at our institution between 1998 and 2016. Read More

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July 2019
1 Read

Acute Deletion of METTL14 in β-Cells of Adult Mice Results in Glucose Intolerance.

Endocrinology 2019 10;160(10):2388-2394

Department of Medicine, The University of Chicago, Chicago, Illinois.

N6-Methyladenosine (m6A) is the most common and abundant mRNA modification that involves regulating the RNA metabolism. However, the role of m6A in regulating the β-cell function is unclear. Methyltransferase-like 14 (METTL14) is a key component of the m6A methyltransferase complex. Read More

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http://dx.doi.org/10.1210/en.2019-00350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760293PMC
October 2019

Clinical applications of (epi)genetics in gastroenteropancreatic neuroendocrine neoplasms: Moving towards liquid biopsies.

Rev Endocr Metab Disord 2019 09;20(3):333-351

Center for Oncological Research (CORE), University of Antwerp and Antwerp University Hospital, Universiteitsplein 1, 2610, Wilrijk, Belgium.

High-throughput analysis, including next-generation sequencing and microarrays, have strongly improved our understanding of cancer biology. However, genomic data on rare cancer types, such as neuroendocrine neoplasms, has been lagging behind. Neuroendocrine neoplasms (NENs) develop from endocrine cells spread throughout the body and are highly heterogeneous in biological behavior. Read More

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http://dx.doi.org/10.1007/s11154-019-09508-wDOI Listing
September 2019
3 Reads

Pre- and intraoperative diagnostic requirements, benefits and risks of minimally invasive and robotic surgery for neuroendocrine tumors of the pancreas.

Best Pract Res Clin Endocrinol Metab 2019 10 10;33(5):101294. Epub 2019 Jul 10.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital, APHP, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, France. Electronic address:

Pancreatic neuroendocrine tumours (PanNET) are rare tumours, accounting for 1%-2% of all pancreatic neoplasms. These tumors are classified as functioning neuroendocrine tumours (F-PanNETs) or non-functioning (NF-PanNETs) depends on whether the tumour is associated with clinical hormonal hypersecretion syndrome or not. In the last decades, diagnosis of PanNETs has increased significantly due to the widespread of cross-sectional imaging. Read More

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http://dx.doi.org/10.1016/j.beem.2019.101294DOI Listing
October 2019
5 Reads

Reappraisal of a 2-Cm Cut-Off Size for the Management of Cystic Pancreatic Neuroendocrine Neoplasms: A Multicenter International Study.

Ann Surg 2019 Jul 24. Epub 2019 Jul 24.

Department of Digestive, Pancreatic and Endocrine Surgery, Cochin Hospital, APHP, Paris, France.

MINI: The characteristics of cystic pancreatic neuroendocrine neoplasms (cPanNENs) are largely unknown, and their clinical management remains unclear; specifically, an observational strategy for asymptomatic cPanNENs ≤2 cm has been proposed by recent guidelines, but evidence is scarce and limited to single institutional series. In this international cohort study of 263 resected cPanNENs from 16 institutions worldwide, a preoperative size >2 cm was independently associated with aggressive behavior both in the whole cohort and in the subset of asymptomatic patients; notably, only 1 of 61 asymptomatic cPanNENs ≤2 cm was aggressive. Based on these results, a watch-and-wait policy for sporadic asymptomatic cPanNENs ≤2 cm seems justified and safe. Read More

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http://dx.doi.org/10.1097/SLA.0000000000003508DOI Listing
July 2019
2 Reads