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    5152 results match your criteria Neoplasms of the Endocrine Pancreas

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    Cystic degeneration of neuro endocrine tumor of pancreas and Crohn's disease: true or coincidental association?
    Pan Afr Med J 2016 15;25. Epub 2016 Sep 15.
    Department Of Surgery, FSI Hospital, Marsa, Tunisia.
    Pancreatic endocrine tumors (PETs) or islet cell tumors are rare lesions, the incidence of which is estimated to be less than 1 per 100,000 person-years in the general population. PETs can be divided into functional (exhibit a distinct clinical syndrome due to hormone hypersecretion) and non-functional tumors. The majority of PETs are non-functional. Read More

    Acute pancreatitis after thoracic duct ligation for iatrogenic chylothorax. A case report.
    BMC Surg 2017 Jan 23;17(1). Epub 2017 Jan 23.
    Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1211, Geneva, Switzerland.
    Background: To report the association between thoracic duct ligation and acute pancreatitis. The association between sudden stop of lymphatic flow and pancreatitis has been established in experimental models.

    Case Presentation: A 57-year-old woman operated for thymoma presented a iatrogenic chylothorax. Read More

    A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report.
    Diagn Pathol 2017 Jan 19;12(1):10. Epub 2017 Jan 19.
    Department of Pathology, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, 567 Baekje-daero, Dukjin-gu, Jeonju, 561-756, Republic of Korea.
    Background: Acinar cell carcinoma represents only 1-2% of exocrine pancreatic neoplasms. On exceptionally rare occasions, primary acinar cell carcinoma can occur in ectopic locations. Herein, we report a case of pure pancreatic-type acinar cell carcinoma arising in the stomach. Read More

    Enucleation: A treatment alternative for branch duct intraductal papillary mucinous neoplasms.
    Surgery 2017 Mar 22;161(3):602-610. Epub 2016 Nov 22.
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address:
    Background: Small, asymptomatic, branch-duct intraductal papillary mucinous neoplasms of the pancreas are often kept under surveillance despite their malignant potential. The management of branch-duct intraductal papillary mucinous neoplasm is controversial with regard to indications and extent of any operative intervention. The present study aimed to evaluate enucleation as an alternative operative approach for branch-duct intraductal papillary mucinous neoplasms to exclude and prevent malignancy. Read More

    Giant insulinoma: report of a case and review of published reports.
    Surg Case Rep 2016 Dec 19;2(1):136. Epub 2016 Nov 19.
    Department of Surgery, Hitachi General Hospital, 2-1-1 Jonan-cho, Hitachi, Ibaraki, 317-0077, Japan.
    Background: Larger insulinomas are reportedly more likely to be malignant; however, their biological behavior has not been clearly elucidated. We here report the characteristics and treatment of a giant insulinoma with local invasion and lymph node metastasis. We also review published reports concerning the clinical features of giant insulinomas and comparing their grading with that of pancreatic neuroendocrine tumors. Read More

    A rare case with synchronous gastric gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and uterine leiomyoma.
    World J Surg Oncol 2016 Nov 15;14(1):287. Epub 2016 Nov 15.
    Department of General and Hepato-pancreatic Surgery, University Hospital "Alexandrovska"-Sofia, 1 Georgi Sofiiski Str, 1431, Sofia, Bulgaria.
    Background: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. Read More

    Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma.
    J Cancer Res Clin Oncol 2016 Dec 14;142(12):2585-2591. Epub 2016 Sep 14.
    Department of Internal Medicine III, Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany.
    Purpose: Acinar cell carcinoma (ACC) of the pancreas is a very rare cancer, constituting 1 % of all malignant non-endocrine pancreatic tumors. Only very limited data exist to guide treatment in patients with advanced ACC.

    Methods: Between 2000 and 2015, 15 patients with ACC were diagnosed and/or treated at our high-volume comprehensive cancer center. Read More

    Clinical trials for BET inhibitors run ahead of the science.
    Drug Discov Today Technol 2016 Mar 21;19:45-50. Epub 2016 Jul 21.
    Department of Medicine, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address:
    Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4, one of the targets of these inhibitors, which is thought to cooperate with MYC, a long-desired target for cancer therapeutics. However, no current inhibitor is selective for BRD4 among the three somatic BET proteins, which include BRD2 and BRD3; their respective functions are partially overlapping and none are functionally redundant with BRD4. Read More

    Clinicopathological Features of Intraductal Papillary Mucinous Neoplasms of Pancreas in a Tertiary Care Center: A 14 Year Retrospective Study.
    J Clin Diagn Res 2016 Aug 1;10(8):EC10-3. Epub 2016 Aug 1.
    Assistant Professor, Department of Hepatopancreaticobiliary (HPB) Surgery, Christian Medical College Hospital , Vellore, Tamil Nadu, India .
    Introduction: Pancreatic surgeries are usually performed for inflammatory conditions and neoplasms. Intraductal Papillary Mucinous Neoplasm (IPMN) account for approximately 5-7% of all pancreatic neoplasms in western literature. To the best of our knowledge, there has been no published literature in Indian subcontinent on IPMN. Read More

    Comparison of postoperative early and late complications between pancreas-sparing duodenectomy and pancreatoduodenectomy.
    Surg Today 2016 Sep 21. Epub 2016 Sep 21.
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan.
    Purpose: Pancreas-sparing duodenectomy (PSD) represents an alternative procedure to pancreatoduodenectomy (PD) for patients with duodenal neoplasms.

    Methods: The postoperative early and late complications of 21 patients who underwent PSD between 1992 and 2014 were compared with those of 44 patients with soft pancreatic parenchyma who underwent PD between 2009 and 2014.

    Results: The median operation time and blood loss were less in the PSD group than in the PD group (P < 0. Read More

    Survival variability of controls and definition of imaging endpoints for longitudinal follow-up of pancreatic ductal adenocarcinoma in rats.
    J Cancer Res Clin Oncol 2017 Jan 12;143(1):29-34. Epub 2016 Sep 12.
    IRCAD, University Hospital of Strasbourg, 1 place de l'hôpital, Strasbourg, France.
    Background: The 3Rs guideline is the gold standard for ethics in animal experimentation. Two of those rules, namely refinement and reduction, require further improvement. The objective of this study was to define pathways to better compliance with these prerequisites. Read More

    Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors.
    Minerva Endocrinol 2016 Dec;41(4):490-8
    Department of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy -
    Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum. Read More

    18F-DOPA PET/CT Physiological Distribution and Pitfalls: Experience in 215 Patients.
    Clin Nucl Med 2016 Oct;41(10):753-60
    From the *Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, IBFM-CNR, Italian National Research Council, Catanzaro; †Department of Biomedicine and Prevention, University "Tor Vergata," Rome; ‡Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila; Departments of §Neuroendocrinology, and ∥Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli, Isernia; ¶Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome, and IRCCS Neuromed, Pozzilli (IS), Italy; and **Department of Nuclear Medicine, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
    Purpose: F-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-DOPA uptake.

    Patients And Methods: We examined 215 patients with F-DOPA PET/CT. Read More

    Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
    Hosp Pract (1995) 2016 Aug 18;44(3):109-19. Epub 2016 Jul 18.
    a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.
    Pancreatic neuroendocrine tumors (PNETs) are neoplasms that arise from the hormone producing cells of the islets of Langerhans, also known as pancreatic islet cells. PNETs are considered a subgroup of neuroendocrine tumors, and have unique biology, natural history and clinical management. These tumors are classified as 'functional' or 'non-functional' depending on whether they release peptide hormones that produce specific hormone- related symptoms, usually in established patterns based on tumor subtype. Read More

    Intraoperative portal vein insulin assay combined with occlusion of the pancreas for complex pancreatogenous hypoglycemia: Two cases report.
    Medicine (Baltimore) 2016 Jun;95(26):e3928
    Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.
    Intraoperative localization and confirmation of complete resection of the hypersecreting tissue are the 2 main challenges in the management of pancreatogenous hypoglycemia. Here, we report our experience with intraoperative portal vein insulin assay combined with occlusion of the pancreas in the management of pancreatogenous hypoglycemia. Clinical courses of 2 patients with biochemical evidence of a pancreatogenous hypoglycemia were studied. Read More

    The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report.
    Hiroshima J Med Sci 2016 Mar;65(1):13-7
    The localization and diagnosis of microgastrinomas in a patient with multiple endocrine neoplasia type 1 is difficult preoperatively. The selective arterial calcium injection (SACI) test is a valid diagnostic method for the preoperative diagnosis of these invisible microgastrinomas. We report a rare case of multiple invisible duodenal microgastrinomas with severe duodenal stenosis diagnosed preoperatively by using the SACI test. Read More

    Complete metastasectomy for renal cell carcinoma: Comparison of five solid organ sites.
    J Surg Oncol 2016 Sep 23;114(3):375-9. Epub 2016 Jun 23.
    Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background And Objectives: Patients with metastatic RCC can undergo metastasectomy to improve survival time. Our goal was to provide and compare characteristics and oncological outcomes of RCC patients who underwent complete metastasectomy at a single organ site.

    Methods: A total of 138 RCC patients were identified as undergoing complete metastasectomy at a single organ site including adrenal, lung, liver, pancreas, or thyroid. Read More

    Single-centre experience of extending indications for percutaneous intraportal islet autotransplantation (PIPIAT) after pancreatic surgery to prevent diabetes: feasibility, radiological aspects, complications and clinical outcome.
    Br J Radiol 2016 Aug 21;89(1064):20160246. Epub 2016 Jun 21.
    1 Department of Radiology, San Raffaele Scientific Institute, Milan, Italy.
    Objective: Islet allotransplantation is a less invasive alternative to surgical pancreas transplantation for Type 1 diabetes, while percutaneous intraportal islet autotransplantation (PIPIAT) is usually performed after pancreatic surgery to prevent diabetes. Our aim was to assess the feasibility, radiological aspects, complications and clinical outcome of PIPIAT following pancreatic surgery for not only chronic pancreatitis but also benign and malignant nodules.

    Methods: From 2008 to 2012, 41 patients were enrolled for PIPIAT 12-48 h after pancreatic surgery (extended pancreatic surgery for chronic pancreatitis and benign/malignant neoplasms). Read More

    A rare case of three different tumors in the same pancreatic specimen: a case report and brief review of the literature.
    J Gastrointest Oncol 2016 Jun;7(3):E52-7
    1 Department of Gastroenterology B, 2 Unit of General and Pancreatic Surgery, Department of Surgery and Pathology, 3 ARC-NET Applied Research on Cancer Center, Department of Pathology and Diagnostics, 4 Department of Radiology, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
    Solid pseudopapillary tumors (SPT) of the pancreas are rare neoplasms mainly affecting young women. Pancreatic serous cystadenomas (SCAs) and pancreatic neuroendocrine tumors (PanNETs) account for about 2% of all pancreatic neoplasms. The combination of these three lesions, to our knowledge, has never been described in literature. Read More

    Robot-assisted spleen preserving pancreatic surgery in MEN1 patients.
    J Surg Oncol 2016 Sep 6;114(4):456-61. Epub 2016 Jun 6.
    Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age.

    Objective: To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques.

    Methods: Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients. Read More

    [Management of gastrinoma].
    Presse Med 2016 Nov 1;45(11):986-991. Epub 2016 Jun 1.
    AP-HP, hôpital Cochin, service de chirurgie digestive hépato-biliaire et endocrienne, Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:
    Gastrinoma is a very rare tumor leading to gastrin hypersecretion and characterised by Zollinger-Ellisson syndrome (ZES) i.e. severe gastric and duodenal ulceration and profuse diarrhea. Read More

    Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma.
    J Korean Med Sci 2016 Jun 11;31(6):1003-6. Epub 2016 Apr 11.
    Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea .
    Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. Read More

    Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report.
    Transplant Proc 2016 Apr;48(3):988-90
    Division of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
    Background: Long-term graft survival of partial pancreas auto-transplantation after total pancreatectomy has not been clarified. The clinical implications of repeat completion pancreatectomy for locally recurrent pancreatic carcinoma in the remnant pancreas after initial pancreatectomy also have not been clarified.

    Methods: We have previously reported a 61-year-old woman presenting with re-sectable carcinoma of the remnant pancreas at 3 years after undergoing a pylorus-preserving pancreaticoduodenectomy for invasive ductal carcinoma of the pancreas head. Read More

    [The biological role of sulfatides].
    Postepy Hig Med Dosw (Online) 2016 May 9;70:489-504. Epub 2016 May 9.
    Zakład Biochemii, Katedra Biochemii, Farmakologii i Toksykologii, Uniwersytet Przyrodniczy we Wrocławiu; Laboratorium Glikobiologii i Oddziaływań Międzykomórkowych, Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu.
    Sulfatides (3-O-sulfogalactosylceramides, sulfated galactocerebrosides, SM4) are esters of sulfuric acid with galactosylceramides. These acidic glycosphingolipids, present at the external leaflet of the plasma membrane, are synthesized by a variety of mammalian cells. They are especially abundant in the myelin sheath of oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Read More

    Multiple Endocrine Neoplasia Syndromes: A Comprehensive Imaging Review.
    Radiol Clin North Am 2016 May 10;54(3):441-51. Epub 2016 Mar 10.
    Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA 02114, USA.
    MEN1, MEN2, and MEN4 comprise a series of familial disorders involving the simultaneous occurrence of tumors in more than one endocrine organ, collectively known as multiple endocrine neoplasia. Patients with this family of disorders develop tumors of the parathyroid gland, pancreas, pituitary gland, adrenal gland, and thyroid gland, along with miscellaneous neuroendocrine tumors of the respiratory and gastrointestinal tracts. Although some patients undergo early prophylactic surgical management, particularly in the setting of familial medullary thyroid carcinoma, many develop tumors later in life. Read More

    [Surgical experience on Roux-en-Y pancreaticojejunostomy after local pancreatic head resection for benign tumors of the pancreatic head].
    Zhonghua Wai Ke Za Zhi 2016 May;54(5):376-9
    Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.
    Objective: To explore the value of Roux-en-Y pancreaticojejunostomy after local pancreatic head resection in treating benign tumors of pancreatic head (BTPH).

    Methods: The clinical data of 12 patients diagnosed as BTPH and treated by Roux-en-Y pancreaticojejunostomy after local pancreatic head resection in Department of General Surgery, Peking University Third Hospital from November 2006 to October 2013 were retrospectively analyzed.Of the 12 cases, 5 patients were male, 7 patients were female, the age of patients ranged from 21 to 64 years(average 42. Read More

    EUS - Fine- Needle Aspiration Biopsy (FNAB) in the Diagnosis of Pancreatic Adenocarcinoma: A Review.
    Rom J Intern Med 2016 Jan-Mar;54(1):24-30
    Solid masses of the pancreas represent a variety of benign and malignant neoplasms of the exocrine and endocrine tissues of the pancreas. A tissue diagnosis is often required to direct therapy in the face of uncertain diagnosis or if the patient is not a surgical candidate either due to advanced disease or comorbidities. Endoscopic ultrasound (EUS) is a relatively new technology that employs endoscopy and high-frequency ultrasound (US). Read More

    Recent Updates on Neuroendocrine Tumors From the Gastrointestinal and Pancreatobiliary Tracts.
    Arch Pathol Lab Med 2016 May;140(5):437-48
    From the Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea (Dr Kim); and the Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (Dr Hong).
    Context: -Gastrointestinal (GI) and pancreatobiliary tracts contain a variety of neuroendocrine cells that constitute a diffuse endocrine system. Neuroendocrine tumors (NETs) from these organs are heterogeneous tumors with diverse clinical behaviors. Recent improvements in the understanding of NETs from the GI and pancreatobiliary tracts have led to more-refined definitions of the clinicopathologic characteristics of these tumors. Read More

    An autoregulatory network between menin and pri-miR-24-1 is required for the processing of its specific modulator miR-24-1 in BON1 cells.
    Mol Biosyst 2016 May;12(6):1922-8
    Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions. MEN1 is characterized by tumours of the parathyroids, of the neuroendocrine cells of the gastroenteropancreatic tract, and of the anterior pituitary. The MEN1 gene, a tumour suppressor gene, encodes the menin protein. Read More

    Metabolic profile in women with polycystic ovary syndrome across adult life.
    Metabolism 2016 May 16;65(5):776-82. Epub 2016 Jan 16.
    Endocrinology and Metabolism Laboratory, West Division, School of Medicine, Hospital San Juan de Dios, University of Chile, Santiago, Chile. Electronic address:
    Objective: To assess insulin sensitivity, insulin secretion and metabolic profile in women with polycystic ovary syndrome (PCOS) in different stages of reproductive life.

    Materials And Methods: In a cross-sectional study, 190 PCOS women (PCOSw) and 99 controls (Cw) aged between 18 and 55years were included. PCOSw and Cw were distributed into 3 stages of reproductive life: early reproductive age (18-34years old), late reproductive age (35-40years old) and perimenopausal period (41-55years old). Read More

    Differential expression of cell-cycle regulators in human beta-cells derived from insulinoma tissue.
    Metabolism 2016 May 23;65(5):736-46. Epub 2016 Feb 23.
    Diabetes Division, St. Josef-Hospital, Ruhr-University Bochum, Gudrunstrasse 56, Bochum 44791, Germany. Electronic address:
    Introduction: The low frequency of beta-cell replication in the adult human pancreas limits beta-cell regeneration. A better understanding of the regulation of human beta-cell proliferation is crucial to develop therapeutic strategies aiming to enhance beta-cell mass.

    Methods: To identify factors that control beta-cell proliferation, cell-cycle regulation was examined in human insulinomas as a model of increased beta-cell proliferation (n=11) and healthy pancreatic tissue from patients with benign pancreatic tumors (n=9). Read More

    Thirty-day outcomes underestimate endocrine and exocrine insufficiency after pancreatic resection.
    HPB (Oxford) 2016 Apr 17;18(4):360-6. Epub 2016 Feb 17.
    Department of Surgery, Division of Surgical Oncology, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:
    Background: Long-term incidence of endocrine and exocrine insufficiency after pancreatectomy is poorly described. We analyze the long-term risks of pancreatic insufficiency after pancreatectomy.

    Methods: Subjects who underwent pancreatectomy from 2002 to 2012 were identified from a prospective database (n = 227). Read More

    Endocrine and metabolic characteristics in polycystic ovary syndrome.
    Dan Med J 2016 Apr;63(4)
    Hirsutism affects 5-25% women, and the condition is most often caused by polycystic ovary syndrome (PCOS). The initial evaluation of hirsute patients should include a thorough medical history, clinical evaluation, and standardized blood samples to diagnose the 5% hirsute patients with rare endocrine disorders. The majority of these examinations can be performed by the patient's general practitioner. Read More

    Granuphilin exclusively mediates functional granule docking to the plasma membrane.
    Sci Rep 2016 Apr 1;6:23909. Epub 2016 Apr 1.
    Laboratory of Molecular Endocrinology and Metabolism, Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan.
    In regulated exocytosis, it is generally assumed that vesicles must stably "dock" at the plasma membrane before they are primed to become fusion-competent. However, recent biophysical analyses in living cells that visualize fluorescent secretory granules have revealed that exocytic behaviors are not necessarily uniform: some granules beneath the plasma membrane are resistant to Ca(2+)-triggered release, while others are accelerated to fuse without a pause for stable docking. These findings suggest that stable docking is unnecessary, and can even be inhibitory or nonfunctional, for fusion. Read More

    Spectrum and Classification of Cystic Neoplasms of the Pancreas.
    Surg Oncol Clin N Am 2016 Apr;25(2):339-50
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA. Electronic address:
    As patients are living longer and axial imaging is more widespread, increasing numbers of cystic neoplasms of the pancreas are found. Intraductal papillary mucinous neoplasms and mucinous cystic neoplasms are the most common. The revised Sendai guidelines provide a safe algorithm for expectant management of certain cystic neoplasms; however, studies are ongoing to identify further subgroups that can be treated nonoperatively. Read More

    Complications of pancreato-duodenectomy.
    Rozhl Chir 2016 Feb;95(2):53-9
    Unlabelled: Pancreato-duodenectomy (PD) is the procedure of choice for management of resectable periampullary and pancreatic cancers and some patients with chronic pancreatitis. PD is one of the most major GI/ HPB surgical procedures performed involving resection of multiple organs and reconstruction with multiple anastomoses. While mortality of PD has been brought down to less than 5% morbidity still remains high. Read More

    Insulin Resistance and β-cell Function Calculated by Homeostasis Model Assessment in Lean, Overweight, and Obese Women with Polycystic Ovary Syndrome.
    J Reprod Med 2016 Jan-Feb;61(1-2):3-10
    Objective: To evaluate the homeostasis model assessment (HOMA) measurement of insulin resistance (IR) and pancreatic β-cell function (%β) and compare those values between groups of healthy-weight, over-weight, and obese women with polycystic ovary syndrome (PCOS).

    Study Design: Retrospective cohort study of women aged 24-48 with PCOS, diagnosed according to 2004 Rotterdam criteria. Participants were grouped by BMI. Read More

    Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration.
    Stem Cells Transl Med 2016 May 17;5(5):694-702. Epub 2016 Mar 17.
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA Center for Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Unlabelled: Human induced pluripotent stem cells (iPSCs) and derived progeny provide invaluable regenerative platforms, yet their clinical translation has been compromised by their biosafety concern. Here, we assessed the safety of transplanting patient-derived iPSC-generated pancreatic endoderm/progenitor cells. Transplantation of progenitors from iPSCs reprogrammed by lentiviral vectors (LV-iPSCs) led to the formation of invasive teratocarcinoma-like tumors in more than 90% of immunodeficient mice. Read More

    Diagnostic Difficulties in a Pediatric Insulinoma: A Case Report.
    Medicine (Baltimore) 2016 Mar;95(11):e3045
    From the Mother and Child Department (IM, SD, GA, II); Surgery Department (MRD); and Oncology Department (LM), "Gr. T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
    Insulinomas are functional neuroendocrine pancreatic tumors rarely encountered in pediatric pathology. Insulinomas are usually solitary and sporadic, but may occur in association with multiple endocrine neoplasia type 1. Whipple's triad-hypoglycemia, simultaneous compatible adrenergic and/or neurological signs, and relief of symptoms upon the administration of glucose-remains the fundamental diagnostic tool. Read More

    Pathology and Surgical Treatment of High-Grade Pancreatic Neuroendocrine Carcinoma: an Evolving Landscape.
    Curr Oncol Rep 2016 May;18(5):28
    Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Rikshospitalet, Postbox 4950, Nydalen, 0424, Oslo, Norway.
    Pancreatic neuroendocrine neoplasms (PNENs) are rare, accounting for less than 5% of all pancreatic tumors. High-grade pancreatic neuroendocrine carcinomas (hgPNECs) represent about 5% of all PNENs. They show highly aggressive behavior with dismal prognosis. Read More

    Identification of tissue-specific cell death using methylation patterns of circulating DNA.
    Proc Natl Acad Sci U S A 2016 Mar 14;113(13):E1826-34. Epub 2016 Mar 14.
    Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel;
    Minimally invasive detection of cell death could prove an invaluable resource in many physiologic and pathologic situations. Cell-free circulating DNA (cfDNA) released from dying cells is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. However, existing methods rely on differences in DNA sequences in source tissues, so that cell death cannot be identified in tissues with a normal genome. Read More

    Irisin immunohistochemistry in gastrointestinal system cancers.
    Biotech Histochem 2016 10;91(4):242-50. Epub 2016 Mar 10.
    j Firat University, School of Medicine , Department of Neurology , Elazig , Turkey.
    Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. Read More

    Pancreatic neuroendocrine tumor mimicking a malignant intraductal papillary mucinous neoplasm.
    Pancreatology 2016 Mar-Apr;16(2):290-2. Epub 2016 Feb 23.
    AP-HP, Hôpitaux Universitaires Est Parisien, Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathologiques, Paris, France; Université Pierre et Marie Curie, Paris 6, Paris, France. Electronic address:

    [Surgical treatment of benign, premalignant and low-risk tumors of the pancreas : Standard resection or parenchyma preserving, local extirpation].
    Chirurg 2016 Jul;87(7):579-84
    Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Deutschland.
    Cystic neoplasms and neuroendocrine adenomas of the pancreas are detected increasingly more frequently and in up to 50 % as asymptomatic tumors. Intraductal papillary mucinous neoplasms, mucinous cystic neoplasms and solid pseudopapillary neoplasms are considered to be premalignant lesions with different rates of malignant transformation. The most frequent neuroendocrine adenomas are insulinomas. Read More

    Pancreatic Cancer Genetics.
    Int J Biol Sci 2016 28;12(3):314-25. Epub 2016 Jan 28.
    Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
    Although relatively rare, pancreatic tumors are highly lethal [1]. In the United States, an estimated 48,960 individuals will be diagnosed with pancreatic cancer and 40,560 will die from this disease in 2015 [1]. Globally, 337,872 new pancreatic cancer cases and 330,391 deaths were estimated in 2012 [2]. Read More

    Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells.
    PLoS One 2016 26;11(2):e0149995. Epub 2016 Feb 26.
    Department of Biochemistry and Molecular Biology, The Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
    Constitutive expression of active Akt (Akttg) drives hyperplasia and hypertrophy of pancreatic β-cells, concomitantly with increased insulin secretion and improved glucose tolerance, and at a later stage the development of insulinoma. To determine which functions of Akt are mediated by ribosomal protein S6 (rpS6), an Akt effector, we generated mice that express constitutive Akt in β-cells in the background of unphosphorylatable ribosomal protein S6 (rpS6P-/-). rpS6 phosphorylation deficiency failed to block Akttg-induced hypertrophy and aneuploidy in β-cells, as well as the improved glucose homeostasis, indicating that Akt carries out these functions independently of rpS6 phosphorylation. Read More

    Genomic analyses identify molecular subtypes of pancreatic cancer.
    Nature 2016 Mar 24;531(7592):47-52. Epub 2016 Feb 24.
    Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.
    Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing. Expression analysis defined 4 subtypes: (1) squamous; (2) pancreatic progenitor; (3) immunogenic; and (4) aberrantly differentiated endocrine exocrine (ADEX) that correlate with histopathological characteristics. Squamous tumours are enriched for TP53 and KDM6A mutations, upregulation of the TP63∆N transcriptional network, hypermethylation of pancreatic endodermal cell-fate determining genes and have a poor prognosis. Read More

    Pancreatic neuroendocrine tumors in twelve baboons (Papio spp.).
    J Med Primatol 2016 Apr 22;45(2):85-91. Epub 2016 Feb 22.
    Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
    Background: Pancreatic neuroendocrine tumors (PNETs) are rare in nonhuman primates and in humans.

    Methods: Twenty-one PNETs from twelve female baboons (Papio spp.) from the Southwest National Primate Research Center were evaluated using histopathology and immunohistochemistry. Read More

    Islet Cell Tumors of the Pancreas.
    Gastroenterol Clin North Am 2016 Mar 13;45(1):83-100. Epub 2016 Jan 13.
    Division of Gastroenterology, Department of Medicine Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1069, New York, NY 10029, USA. Electronic address:
    Islet cell tumors of the pancreas, also known as pancreatic neuroendocrine tumors, constitute less than 5% of pancreatic tumors, and 7% of all neuroendocrine tumors. Most are non-functional, and patients often present with metastatic disease. Functional tumors present with distinct clinical syndromes. Read More

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