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    5311 results match your criteria Neoplasms of the Endocrine Pancreas

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    [Surgical strategies for small sporadic neuroendocrine pancreatic tumors].
    Chirurg 2018 Apr 10. Epub 2018 Apr 10.
    Sektionsleitung Endokrine Chirurgie, Klinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg, Deutschland.
    Small (<2 cm) sporadic neuroendocrine pancreatic neoplasms (pNENs) are a heterogeneous group of neoplasms, which can be separated into functionally active or non-functional tumors. Functionally active pNENs release various hormones, such as insulin, gastrin, glucagon and vasoactive intestinal hormones and therefore lead to severe symptoms independent of their size. The main symptoms include hypoglycemia, coma (insulinoma), diarrhea (gastrinoma, VIPoma), intestinal ulcers (gastrinoma) and hyperglycemia (glucagonoma). Read More

    Surgical resection of neuroendocrine tumors of the pancreas (pNETs) by minimally invasive surgery: the laparoscopic approach.
    Gland Surg 2018 Feb;7(1):12-19
    Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
    Neuroendocrine tumors of the pancreas (pNETs) are a rare group of neoplasms that originate from the endocrine portion of the pancreas. Tumors that either secrete or do not secrete compounds, resulting in symptoms, can be classified as functioning and non-functioning pNETs, respectively. The prevalence of such tumors has recently increased due to the use of more sensitive imaging techniques, such as multidetector computed tomography, magnetic resonance imaging and endoscopic ultrasound. Read More

    Second malignancies in patients with myeloproliferative neoplasms: a population-based cohort study of 9379 patients.
    Leukemia 2018 Jan 30. Epub 2018 Jan 30.
    Department of Medicine, Division of Hematology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
    To determine the risk of a wide range of second malignancies in patients with myeloproliferative neoplasms (MPNs), we conducted a large population-based study and compared the results to matched controls. From national Swedish registers, 9379 patients with MPNs diagnosed between 1973 and 2009, and 35,682 matched controls were identified as well as information on second malignancies, with follow-up until 2010. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression and a flexible parametric model. Read More

    Predictive factors of endocrine and exocrine insufficiency after resection of a benign tumour of the pancreas.
    Ann Endocrinol (Paris) 2018 Apr 8;79(2):53-61. Epub 2018 Mar 8.
    CHU de Poitiers, service de chirurgie viscérale, 2, rue de la Milétrie, 86000 Poitiers, France.
    Background: The aim of the present study is to evaluate the risk factors of endocrine and exocrine insufficiency occurring few years after pancreatic resections in a consecutive series of patients who underwent pancreatoduodenectomy (PD), left pancreatectomy (LP) or enucleation for benign neoplasms at a referral centre.

    Methods: Pancreatic exocrine insufficiency (PEI) was defined by the onset of steatorrhea associated with weight loss, and endocrine insufficiency was determinate by fasting plasma glucose. Association between pancreatic insufficiency and clinical, pathological, and perioperative features was studied using univariate and multivariate Cox regression analysis. Read More

    Primary adenosquamous cell carcinoma of the pancreas: the use of endoscopic ultrasound guided - fine needle aspiration to establish a definitive cytologic diagnosis.
    Rev Gastroenterol Peru 2017 Oct-Dec;37(4):370-373
    Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sâo Paulo. Sâo Paulo, Brazil.
    Pancreatic cancer is the second most common malignancy of the gastrointestinal tract in the US, and adenocarcinoma has been identified as the most common type of pancreatic cancer. Different types of pancreatic cancers have been classified: adenocarcinoma, ductal adenosquamous carcinoma, solid pseudopapillary tumors, endocrine neoplasms, acinar cell carcinoma, squamous cell carcinoma, cystic tumors, primary lymphoma of the pancreas, and metastatic lesions of the pancreas. Adenosquamous carcinoma is extremely rare, behave in a very aggressive way and is responsible for the 1 to 4% of the pancreatic exocrine neoplastic lesions. Read More

    Expression of Beclin 1 and Bcl-2 in pancreatic neoplasms and its effect on pancreatic ductal adenocarcinoma prognosis.
    Oncol Lett 2017 Dec 18;14(6):7849-7861. Epub 2017 Oct 18.
    Department of Pancreas and Endocrine Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China.
    Aberrant expression of Beclin 1 and B-cell lymphoma-2 (Bcl-2) has been identified in a variety of human tumors; however, little information is available for pancreatic neoplasms. The present study analyzed the expression of Beclin 1 and Bcl-2 in pancreatic ductal adenocarcinoma (PDAC) and solid pseudopapillary neoplasm (SPN) of the pancreas, and evaluated their prognostic significance for PDAC. The present study included 117 PDAC, 43 SPN and 32 chronic pancreatitis (CP) cases. Read More

    gene mutations in endocrine tumors.
    Endocr Relat Cancer 2018 Mar 12;25(3):R197-R208. Epub 2018 Jan 12.
    Division of PathologyDepartment of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada.
    In this review, the importance of the gene in the function of endocrine cells is discussed. There is conclusive evidence that mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian and testicular tumors. Read More

    Common genetic variants associated with pancreatic adenocarcinoma may also modify risk of pancreatic neuroendocrine neoplasms.
    Carcinogenesis 2018 Mar;39(3):360-367
    Genomic Epidemiology Group, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
    Pancreatic neuroendocrine neoplasms (pNEN) account for less than 5% of all pancreatic neoplasms and genetic association studies on susceptibility to the disease are limited. We sought to identify possible overlap of genetic susceptibility loci between pancreatic ductal adenocarcinoma (PDAC) and pNEN; therefore, PDAC susceptibility variants (n = 23) from Caucasian genome-wide association studies (GWAS) were genotyped in 369 pNEN cases and 3277 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium to evaluate the odds associated with pNEN risk, disease onset and tumor characteristics. Main effect analyses showed four PDAC susceptibility variants-rs9854771, rs1561927, rs9543325 and rs10919791 to be associated with pNEN risk. Read More

    Benign Tumors of the Pancreas-Radical Surgery Versus Parenchyma-Sparing Local Resection-the Challenge Facing Surgeons.
    J Gastrointest Surg 2018 Mar 3;22(3):562-566. Epub 2018 Jan 3.
    Department of General and Visceral Surgery, University of Ulm, c/o Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
    Pancreaticoduodenectomy and left-sided pancreatectomy are the surgical treatment standards for tumors of the pancreas. Surgeons, who are requested to treat patients with benign tumors, using standard oncological resections, face the challenge of sacrificing pancreatic and extra-pancreatic tissue. Tumor enucleation, pancreatic middle segment resection and local, duodenum-preserving pancreatic head resections are surgical procedures increasingly used as alternative treatment modalities compared to classical pancreatic resections. Read More

    Short-term outcomes and risk factors for pancreatic fistula after pancreatic enucleation: A single-center experience of 142 patients.
    J Surg Oncol 2018 Feb 27;117(2):182-190. Epub 2017 Dec 27.
    Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
    Background: Enucleation is increasingly used for benign or low-grade pancreatic neoplasms. Enucleation preserves the pancreatic parenchyma as well as decreases the risk of long-term endocrine and exocrine dysfunction, but may be associated with a higher rate of postoperative pancreatic fistula (POPF). The aim of this study was to assess short-term outcomes, in particular, POPF. Read More

    Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review.
    Autops Case Rep 2017 Oct-Dec;7(4):51-57. Epub 2017 Dec 8.
    St. John Hospital and Medical Center, Department of Pathology. Detroit, MI, USA.
    Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare and poorly described pancreatic malignancy. It is comprised of mononuclear, pleomorphic, and undifferentiated cells as well as osteoclast-like giant cells (OGC's). It constitutes less than 1% of pancreatic non-endocrine neoplasia and is twice as likely to occur in females as in males. Read More

    Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms.
    Endocr Metab Immune Disord Drug Targets 2017 12 13. Epub 2017 Dec 13.
    University Hospital - Endocrine Oncology Uppsala. Sweden.
    Well-established criteria for evaluating the response to treatment and the appropriate follow-up of individual patients are critical in clinical oncology. The current evidence-based data on these issues in terms of the management of gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are unfortunately limited. This document by the Italian Association of Clinical Endocrinologists (AME) on the criteria for the follow-up of GEP-NEN patients is aimed at providing comprehensive recommendations for everyday clinical practice based on both the best available evidence and the combined opinion of an interdisciplinary panel of experts. Read More

    Neuroendocrine Neoplasms: Dichotomy, Origin and Classifications.
    Visc Med 2017 Oct 16;33(5):324-330. Epub 2017 Oct 16.
    Consultation Center for Pancreatic and Endocrine Tumors, Institute of Pathology, Technical University München, Munich, Germany.
    Neuroendocrine neoplasms (NENs) are heterogeneous tumors with a common phenotype. There are two fundamentally different groups of NENs: well-differentiated, low-proliferating NENs, called neuroendocrine tumors (NETs) or carcinoids, and poorly differentiated, highly proliferating NENs, called small- or large-cell neuroendocrine carcinomas (NECs). This NEN dichotomy is probably due to an origin from different neuroendocrine progenitor cells. Read More

    Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model.
    J Vis Exp 2017 Oct 16(128). Epub 2017 Oct 16.
    Department of Pathology and Laboratory Medicine, Weill Cornell Medicine;
    Metastatic cancer accounts for 90% of deaths in patients with solid tumors. There is an urgent need to better understand the drivers of cancer metastasis and to identify novel therapeutic targets. To investigate molecular events that drive the progression from primary cancer to metastasis, we have developed a bitransgenic mouse model, RIP-Tag; RIP-tva. Read More

    Update in the Therapy of Advanced Neuroendocrine Tumors.
    Curr Treat Options Oncol 2017 Nov 16;18(12):72. Epub 2017 Nov 16.
    Neuroendocrine Tumor Unit, Endocrinology and Metabolism Department, Division of Medicine, Hadassah-Hebrew University Medical Center, P.O.B. 12000, 91120, Jerusalem, Israel.
    Opinion Statement: Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. Read More

    A case report of mixed acinar-endocrine carcinoma of the pancreas treated with S-1 chemotherapy: Does it work or induce endocrine differentiation?
    Medicine (Baltimore) 2017 Nov;96(45):e8534
    aDepartment of Gastroenterology and Hepatology, Kobe City Medical Center West Hospital bDepartment of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
    Rationale: Acinar cell carcinomas (ACCs) and mixed acinar-endocrine carcinomas (MAECs) of the pancreas are rare, accounting for only 1% of pancreatic tumors. Although both typically present at an advanced stage, chemotherapeutic regimes have not yet been standardized.

    Patient Concerns: A 65-year-old man presented with a large mass in the pancreatic tail with multiple liver metastases. Read More

    Binding pancreaticogastrostomy anastomosis in central pancreatectomy: A single center experience.
    Medicine (Baltimore) 2017 Nov;96(45):e8354
    Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China.
    A growing number of central pancreatectomies are performed. However, reconstruction of pancreaticoenteral digestive continuity after central pancreatectomy remains debated. This study evaluates the short-term outcomes of binding pancreaticogastrostomy anastomosis in central pancreatectomy. Read More

    Ki67 labeling index: assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms.
    Virchows Arch 2018 Mar 13;472(3):341-349. Epub 2017 Nov 13.
    Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
    In 1983, a monoclonal antibody, Ki67, was generated, that labeled the nuclei of proliferating non-neoplastic and neoplastic cells. The name Ki67 derived from the city of Kiel (Ki) where the antibody was produced in the university department of pathology and refers to the number of the original clone (67). Systematic assessment of the proliferative activity of tumors using Ki67 started in the 1990s, when Ki67, which only worked on frozen tissue, was complemented by the antibody MIB-1 that also worked in formalin-fixed tissues. Read More

    The utility of Ga-DOTATATE positron-emission tomography/computed tomography in the diagnosis, management, follow-up and prognosis of neuroendocrine tumors.
    Future Oncol 2018 Jan 26;14(2):111-122. Epub 2017 Oct 26.
    Sackler Faculty of Medicine, Tel Aviv University, Israel.
    Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by 'cold' somatostatin analogs for therapy or by 'hot' radiolabeled somatostatin analogs for tumor localization and treatment. Read More

    Cystic pancreatic neuroendocrine tumors (cPNETs): a systematic review and meta-analysis of case series.
    Rev Esp Enferm Dig 2017 Nov;109(11):778-787
    General Surgery, Clínica Universidad de Navarra, España.
    Cystic pancreatic neuroendocrine tumors represent 13% of all neuroendocrine tumors. The aim of this study is to analyze the phenotype and biologic behavior of resected cystic neuroendocrine tumors. A systematic review and meta-analysis were conducted until September 2016 using a search in Medline, Scopus, and EMBASE with the terms "cystic pancreatic endocrine neoplasm", "cystic islets tumors" and "cystic islets neoplasms". Read More

    Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer.
    Biochem Biophys Res Commun 2017 12 16;494(1-2):113-119. Epub 2017 Oct 16.
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, PR China. Electronic address:
    Dysregulated potassium (K) channels have previously been shown to promote the development and progression of many types of cancers. Meanwhile, K channels are particularly important in regulating the endocrine and exocrine functions of pancreas. However, the expression pattern and prognostic significance of K channels in pancreatic ductal adenocarcinoma (PDAC) remain unknown. Read More

    Imaging and Screening of Pancreatic Cancer.
    Radiol Clin North Am 2017 Nov;55(6):1223-1234
    Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
    Given the low disease prevalence of both exocrine and endocrine cancers in the general population, screening is not recommended. However, in as many as 25% of cases there is a precursor lesion or an identifiable genetic predisposition. For these patients at increased risk, screening with imaging is recommended. Read More

    Enucleation of non-invasive tumors in the proximal pancreas: indications and outcomes compared with standard resections.
    J Zhejiang Univ Sci B 2017 Oct.;18(10):906-916
    Department of Surgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
    Objective: The aim of this study was to evaluate the safety and efficiency of enucleation (EU) for proximal pancreatic non-invasive neoplasms.

    Methods: Patients with solitary non-invasive neoplasms in the proximal pancreas from January 1998 to April 2014 at the Second Affiliated Hospital of Zhejiang University, Hangzhou, China were included. Different operations and outcomes were analyzed. Read More

    [High grade insulinoma detected in a patient with a 5-year history of severe hypoglycemias].
    Pan Afr Med J 2017 4;27:250. Epub 2017 Aug 4.
    Service de Chirurgie Viscérale A, CHU Hassan II, Fès, Maroc.
    Functional endocrine tumors of the pancreas are rare. Among them insulinomas are the most common types. The majority of the patients with insulinoma are between 30 and 60 years of age and 59% of them are women. Read More

    Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.
    Nat Commun 2017 10 3;8(1):767. Epub 2017 Oct 3.
    The Diabetes Obesity and Metabolism Institute, The Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
    Although diabetes results in part from a deficiency of normal pancreatic beta cells, inducing human beta cells to regenerate is difficult. Reasoning that insulinomas hold the "genomic recipe" for beta cell expansion, we surveyed 38 human insulinomas to obtain insights into therapeutic pathways for beta cell regeneration. An integrative analysis of whole-exome and RNA-sequencing data was employed to extensively characterize the genomic and molecular landscape of insulinomas relative to normal beta cells. Read More

    Genetic analysis of parathyroid and pancreatic tumors in a patient with multiple endocrine neoplasia type 1 using whole-exome sequencing.
    BMC Med Genet 2017 10 2;18(1):106. Epub 2017 Oct 2.
    Division of Intractable Diseases, Center for Biomedical Sciences, Korea National Institute of Health, 187 Osongsaengmyeing2-ro, Cheongju-si, Chungcheongbuk-do, 28159, South Korea.
    Background: Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant hereditary disorder characterized by the presence of endocrine tumors affecting the parathyroid, pancreas, and pituitary. A heterozygous germline inactivating mutation in the MEN1 gene (first hit) may be followed by somatic loss of the remaining normal copy or somatic mutations in the MEN1 gene (second hit). Whole-exome sequencing has been successfully used to elucidate the mutations associated with the different types of tumors. Read More

    Endocrine and neuroendocrine cytopathology.
    Minerva Endocrinol 2017 Sep 25. Epub 2017 Sep 25.
    Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.
    Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. Read More

    Pancreatic neuroendocrine tumor with complete replacement of the pancreas by serous cystic neoplasms in a patient with von Hippel-Lindau disease: a case report.
    Surg Case Rep 2017 Sep 25;3(1):105. Epub 2017 Sep 25.
    Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.
    Background: von Hippel-Lindau disease is a dominantly inherited multi-system syndrome with neoplastic hallmarks. Pancreatic lesions associated with von Hippel-Lindau include serous cystic neoplasms, simple cysts, and neuroendocrine tumors. The combination of pancreatic neuroendocrine tumors and serous cystic neoplasms is relatively rare, and the surgical treatment of these lesions must consider both preservation of pancreatic function and oncological clearance. Read More

    Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response.
    Endocrinology 2017 10;158(10):3162-3173
    School of Health and Biomedical Sciences, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia.
    The metabolic syndrome is associated with an increase in the activation of the renin angiotensin system, whose inhibition reduces the incidence of new-onset diabetes. Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes β-cell inflammation and dysfunction, which may be an early step in the development of type 2 diabetes. The aim of this study was to determine how AngII causes β-cell dysfunction. Read More

    [Multiple endocrine neoplasia].
    Dtsch Med Wochenschr 2017 Sep 8;142(18):1379-1389. Epub 2017 Sep 8.
    Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. Read More

    O-(2-F-fluoroethyl)-l-tyrosine (F-FET) uptake in insulinoma: first results from a xenograft mouse model and from human.
    Nucl Med Biol 2017 Oct 12;53:21-28. Epub 2017 Jul 12.
    Université de Strasbourg, CNRS, IPHC, UMR 7178, F-67000, Strasbourg, France.
    Introduction: Herein we have evaluated the uptake of O-(2-F-fluoroethyl)-l-tyrosine (F-FET) in insulinoma in comparison with those of 6-F-fluoro-3,4-dihydroxy-l-phenylalanine (F-FDOPA) providing first data from both murine xenograft model and one patient with proved endogenous hyperinsulinemic hypoglycemia.

    Methods: Dynamic F-FET and carbidopa-assisted F-FDOPA PET were performed on tumor-bearing nude mice after subcutaneous injection of RIN-m5F murine beta cells and on a 30-year-old man with type-1 multiple endocrine neoplasia and hyperinsulinemic hypoglycemia defined by a positive fasting test.

    Results: Seven and three nude mice bearing a RIN-m5F insulinoma xenograft were respectively studied by F-FET and F-FDOPA μPET. Read More

    Lack of Association for Reported Endocrine Pancreatic Cancer Risk Loci in the PANDoRA Consortium.
    Cancer Epidemiol Biomarkers Prev 2017 Aug;26(8):1349-1351
    Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms for which very little is known about either environmental or genetic risk factors. Only a handful of association studies have been performed so far, suggesting a small number of risk loci. To replicate the best findings, we have selected 16 SNPs suggested in previous studies to be relevant in PNET etiogenesis. Read More

    Pancreatic Imaging.
    Endocrinol Metab Clin North Am 2017 Sep 12;46(3):761-781. Epub 2017 Jun 12.
    Department of Radiology, UMass Memorial Medical Center, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address:
    Imaging of the endocrine pancreas is dominated by neuroendocrine tumors, a diverse category of neoplasms that may or may not cause symptoms from hormone hypersecretion. These tumors may also be evidence of several different genetic syndromes. Understanding the usefulness of different imaging modalities and entities that simulate neuroendocrine tumors is key for both radiologists and referring physicians. Read More

    Perioperative management of endocrine insufficiency after total pancreatectomy for neoplasia.
    Langenbecks Arch Surg 2017 Sep 21;402(6):873-883. Epub 2017 Jul 21.
    Department of Medicine, Division of Endocrinology, University of Illinois at Chicago and Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
    Purpose: Indications for total pancreatectomy (TP) have increased, including for diffuse main duct intrapapillary mucinous neoplasms of the pancreas and malignancy; therefore, the need persists for surgeons to develop appropriate endocrine post-operative management strategies. The brittle diabetes after TP differs from type 1/2 diabetes in that patients have absolute deficiency of insulin and functional glucagon. This makes glucose management challenging, complicates recovery, and predisposes to hospital readmissions. Read More

    Functional and morphological evolution of remnant pancreas after resection for pancreatic adenocarcinoma.
    Medicine (Baltimore) 2017 Jul;96(28):e7495
    Department of Surgery, Inha University School of Medicine, Incheon, Republic of Korea.
    Functional and morphological evolution of remnant pancreas after resection for pancreatic adenocarcinoma is investigated.The medical records of 45 patients who had undergone radical resection for pancreatic adenocarcinoma from March 2010 to September 2013 were reviewed retrospectively. There were 34 patients in the pancreaticoduodenectomy (PD) group and 10 patients in the distal pancreatectomy (DP) group. Read More

    Regional Metastatic Behavior of Nonfunctional Pancreatic Neuroendocrine Tumors: Impact of Lymph Node Positivity on Survival.
    Pancreas 2017 Aug;46(7):898-903
    From the *Liver and Pancreas Surgery, Portland Providence Cancer Institute; †Providence Portland Medical Center; ‡Division of Liver and Pancreas Surgery, The Oregon Clinic, Portland, OR; and §Overlake Hospital Medical Center, Bellevue, WA.
    Objectives: Literature addressing the significance of lymph node positivity in the management of nonfunctional pancreatic neuroendocrine tumors (PNETs) is conflicting.

    Methods: The National Cancer Data Base was queried for patients who underwent surgical resection of nonfunctional PNETs between 1998 and 2011. Clinical data and overall survival were analyzed using χ and Cox proportional hazards regression. Read More

    Successful pregnancy after mucinous cystic neoplasm with invasive carcinoma of the pancreas in a patient with polycystic ovarian syndrome: a case report.
    J Med Case Rep 2017 Jul 11;11(1):188. Epub 2017 Jul 11.
    Department of Medicine, Orlando Regional Healthcare, Orlando, FL, USA.
    Background: The incidence of invasive cancer within a mucinous cystic neoplasm of the pancreas varies between 6 and 36%. Polycystic ovarian syndrome is a disorder characterized by hyperandrogenism and anovulatory infertility. One surgical treatment that can restore endocrine balance and ovulation in polycystic ovarian syndrome is partial ovarian destruction. Read More

    Treatment of a mixed acinar-endocrine carcinoma with uptake on Gallium-DOTATOC positron emission tomography-computed tomography: A case report.
    Oncol Lett 2017 Jul 24;14(1):547-552. Epub 2017 May 24.
    Department of Gastroenterology and Digestive Oncology, Ghent University Hospital, 9000 Ghent, Belgium.
    The case of a 35-year old female patient with a diagnosis of metastatic mixed acinar-endocrine carcinoma (MAEC) is investigated in the present study. The patient was believed to have a well-differentiated neuroendocrine tumor (NET) with a high Ki-67 index and uptake on Gallium-DOTATOC positron emission tomography-computed tomography for 9 years, and was treated accordingly. The patient had long lasting disease control by treatment with sunitinib, and a response was observed in numerous lesions with peptide receptor radionuclide therapy (PRRT). Read More

    Comparison of pancreatic beta cells and alpha cells under hyperglycemia: Inverse coupling in pAkt-FoxO1.
    Diabetes Res Clin Pract 2017 Sep 19;131:1-11. Epub 2017 May 19.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan, South Korea; Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, South Korea.
    Type 2 diabetes manifests beta cell deficiencies and alpha cell expansion which is consistent with relative insulin deficiency and glucagon oversecretion. The effects of hyperglycemia on alpha cells are not as understood in comparison to beta cells. Hyperglycemia increases oxidative stress, which induces Akt activation or FoxO activation, depending on cell type. Read More

    Synchronous Solid Pseudopapillary Tumor and Insulinoma in an Adolescent MEN1 Patient Presenting with Diagnostic Dilemmas.
    J Clin Res Pediatr Endocrinol 2017 Dec 30;9(4):375-379. Epub 2017 Jun 30.
    İstanbul University İstanbul Faculty of Medicine, Department of Adolescent Medicine and Pediatrics, İstanbul, Turkey.
    Multiple endocrine neoplasia (MEN1) is a rare autosomal dominant disorder characterized by primary hyperparathyroidism, enteropancreatic neuroendocrine tumors, and anterior pituitary adenomas. A 16-year-old male presented to the emergency outpatient clinic with tonic convulsions. Physical examination in the postconvulsive period was unremarkable and revealed a muscular, postpubertal adolescent. Read More

    Management of Incidental Adrenal Masses: A White Paper of the ACR Incidental Findings Committee.
    J Am Coll Radiol 2017 Aug 23;14(8):1038-1044. Epub 2017 Jun 23.
    Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
    The ACR Incidental Findings Committee presents recommendations for managing adrenal masses that are incidentally detected on CT or MRI. These recommendations represent an update to the adrenal component of the JACR 2010 white paper on managing incidental findings in the adrenal glands, kidneys, liver, and pancreas. The Adrenal Subcommittee, constituted by abdominal radiologists and an endocrine surgeon, developed this algorithm. Read More

    Solid Pseudopapillary Tumor of the Pancreas: An Unusual Cause of Abdominal Pain.
    Cureus 2017 May 16;9(5):e1252. Epub 2017 May 16.
    Department of Gastroenterology, Staten Island University Hospital.
    Solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor that accounts for less than one percent of pancreatic tumors. The diagnosis could be challenging as SPN tend to manifest with nonspecific abdominal symptoms, variable radiological features, and inconsistent morphology. The cellular origin of SPN is unclear and might involve ductal, acinar and endocrine stem cells. Read More

    Intestinal heterotopic pancreas involved by simultaneous PanIN-2 lesion and endocrine microadenoma: a unique case.
    J Gastrointestin Liver Dis 2017 Jun;26(2):199-202
    Pathology Department, Victor Babes University of Medicine and Pharmacy;Pathology Department, Pius Brinzeu County Clinical Hospital, Timisoara, Romania.
    We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. Read More

    THE PHYSIOLOGY BEHIND DIABETES MELLITUS IN PATIENTS WITH PHEOCHROMOCYTOMA: A REVIEW OF THE LITERATURE.
    Endocr Pract 2017 Aug 14;23(8):999-1005. Epub 2017 Jun 14.
    Objective: This paper reviews the physiologic mechanisms responsible for glucose intolerance and diabetes mellitus in patients with pheochromocytoma.

    Methods: Google Scholar and PubMed were searched using the following key words: "diabetes," "pheochromocytoma," "adrenoreceptors," and "hyperglycemia." All the articles that were retrieved and reviewed were in the English language. Read More

    Pancreatic Polypeptide Cell Proliferation in the Pancreas and Duodenum Coexisting in a Patient With Pancreatic Adenocarcinoma Treated With a GLP-1 Analog.
    Pancreas 2017 Jul;46(6):820-824
    From the *Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE; †Department of Pathology, Spartanburg Medical Center; ‡Gibbs Cancer Center, Spartanburg Regional Hospital System; and §Department of Surgery, Gibbs Cancer Center, Spartanburg, SC; and ∥UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE.
    A partial pancreaticogastrodudenectomy was performed on a 66-year old man with type 2 diabetes mellitus because of an invasive, moderately differentiated adenocarcinoma in the head of the pancreas. In the adjacent grossly normal tissue of the uncinate process, there was a massive proliferation of pancreatic polypeptide (PP) cells confined to this region and showed invasive pattern. Strikingly, in the heaped area of his duodenum, there was a strikingly large number of PP, glucagon, a few insulin cells in a mini-islet-like patterns composed of glucagon and insulin cells. Read More

    Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells.
    PLoS One 2017 8;12(6):e0179353. Epub 2017 Jun 8.
    Institute of Public Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
    Human induced pluripotent stem cells (hiPSCs) may provide potential resource for regenerative medicine research, including generation of insulin-producing cells for diabetes research and insulin production. Testosterone (T) is an androgen hormone which promotes protein synthesis and improves the management of type 2 diabetes in clinical studies. Concurrently, co-existed hyperandrogenism and hyperinsulinism is frequently observed in polycystic ovary syndrome, congenital adrenal hyperplasia and some of Wermer's syndrome. Read More

    Risk and protective factors for the occurrence of sporadic pancreatic endocrine neoplasms.
    Endocr Relat Cancer 2017 Aug 31;24(8):405-414. Epub 2017 May 31.
    Digestive and Liver Disease UnitSant' Andrea Hospital, Sapienza University of Rome, Rome, Italy
    Pancreatic neuroendocrine neoplasms (PNENs) represent 10% of all pancreatic tumors by prevalence. Their incidence has reportedly increased over recent decades in parallel with that of pancreatic adenocarcinoma. PNENs are relatively rare, and of the few institutions that have published potential risk factors, findings have been heterogeneous. Read More

    Perivascular epithelial cell tumor (PEComa) of the pancreas: A case report and review of literature.
    Medicine (Baltimore) 2017 Jun;96(22):e7050
    aDepartment of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing bDepartment of Oncology, Bozhou People's Hospital, Bozhou cDepartment of Abdominal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen Cancer Hospital, Shenzhen dState Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing eDepartment of Medical Oncology, Affiliated Hospital of Qinghai University, Xining, China.
    Rationale: Perivascular epithelial cell tumors (PEComas) of the pancreas are rare mesenchymal tumors and, to our knowledge, only 20 cases have been reported to date.

    Patient Concerns: We report a 43-year-old female who presented with upper abdominal pain for 1 year. She underwent an exploratory laparotomy at a local hospital, which failed to resect the tumor. Read More

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