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    5178 results match your criteria Neoplasms of the Endocrine Pancreas

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    Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report.
    Surg Case Rep 2017 Dec 30;3(1):51. Epub 2017 Mar 30.
    Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, Osaka City, Osaka, 537-8511, Japan.
    Background: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were treated with surgery and transcatheter arterial chemoembolization (TACE) that later recurred in the stomach. Read More

    Disseminated Pancreatic Neuroendocrine Neoplasm (NEN) with an Uncommon Localisation in the Central Nervous System. A Case Report.
    Pol J Radiol 2017 1;82:120-125. Epub 2017 Mar 1.
    Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland; Department of Radiology, Clinical University Hospital in Olsztyn, Olsztyn, Poland.
    Background: Neuroendocrine neoplasms (NEN) are rare neoplasms that originate from neuroendocrine cells and are characterized by the potential of hormonal activity. Approximately 70% of these tumours are located in the gastrointestinal system (GI), followed by the bronchi, endocrine glands-like C cells of the thyroid (medullary carcinoma), the parasympathetic and sympathetic system (paragangliomas, pheochromocytoma) and other very rare locations. The prevalence of cerebral metastases in neuroendocrine tumours is estimated by various authors to be approximately 1. Read More

    East Versus West: Differences in Surgical Management in Asia Compared with Europe and North America.
    Surg Clin North Am 2017 Apr;97(2):453-466
    Department of Gastroentelogical, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-kogushi, Yamaguchi 755-8505, Japan.
    In recent decades, there has been considerable worldwide progress in the treatment of gastric cancer. Gastrectomy with a modified D2 lymphadenectomy (sparing the distal pancreas and spleen) has increasingly gained acceptance as a preferable standard surgical approach among surgeons in the East and the West. Despite growing consensus significant differences still exist in surgical techniques in clinical trials and clinical practices secondary to variations in epidemiology, clinicopathologic features, and surgical outcomes among geographic regions. Read More

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas.
    BMC Gastroenterol 2017 Mar 7;17(1):37. Epub 2017 Mar 7.
    Division of Endoscopy, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntogun, Shizuoka, 411-8777, Japan.
    Background: In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who developed dysphagia due to reflux esophagitis with severe esophageal stricture. Treatment for his esophageal stricture and ZES was discussed. Read More

    Laparoscopic splenopancreatectomy for an endocrine tumor with cystic changes: a case report.
    Clin Case Rep 2017 Mar 6;5(3):328-332. Epub 2017 Feb 6.
    Department of Gastrointestinal Surgery Tokai University School of Medicine 143 Shimokasuya Isehara Kanagawa 259-1193 Japan.
    The biological behavior of a cystic pancreatic endocrine neoplasm is less aggressive than that of pancreatic neuroendocrine neoplasms, and its prognosis is better. Limited surgery should be considered for cystic pancreatic endocrine neoplasms that are not accompanied preoperatively by lymph node or distant metastasis. Read More

    7, 8-Dihydroxycoumarin (daphnetin) protects INS-1 pancreatic β-cells against streptozotocin-induced apoptosis.
    Phytomedicine 2017 Jan 1;24:119-126. Epub 2016 Dec 1.
    Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong 519085, China. Electronic address:
    Background And Objective: Daphnetin (7, 8-dihydroxycoumarin), a natural coumarin compound, is known to exhibit antioxidant and anti-inflammatrory effects. However, the underlying mechanisms of its anti-apoptotic and antidiabetic effects yet not been examined. Therefore, the present work studied the anti-apoptotic and anti-diabetic effects of daphnetin by in vitro experiments. Read More

    Cystic degeneration of neuro endocrine tumor of pancreas and Crohn's disease: true or coincidental association?
    Pan Afr Med J 2016 15;25. Epub 2016 Sep 15.
    Department Of Surgery, FSI Hospital, Marsa, Tunisia.
    Pancreatic endocrine tumors (PETs) or islet cell tumors are rare lesions, the incidence of which is estimated to be less than 1 per 100,000 person-years in the general population. PETs can be divided into functional (exhibit a distinct clinical syndrome due to hormone hypersecretion) and non-functional tumors. The majority of PETs are non-functional. Read More

    A case of concomitant colitic cancer and intrahepatic cholangiocarcinoma during follow-up for ulcerative colitis.
    Clin J Gastroenterol 2017 Apr 30;10(2):157-162. Epub 2017 Jan 30.
    Division of Hepato-Biliary-Pancreas Surgery, Department of Surgery, University of Miyazaki Faculty of Medicine, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
    Colitis-associated colorectal cancer (CAC) is known to occur in long-standing and extensive ulcerative colitis (UC). Furthermore, UC is known to complicate primary sclerosing cholangitis (PSC), which subsequently results in an increased risk of developing cholangiocarcinoma. We report a case of colitis-associated rectal cancer (CARC) accompanied by intrahepatic cholangiocarcinoma (ICC) based on UC and PSC. Read More

    Acute pancreatitis after thoracic duct ligation for iatrogenic chylothorax. A case report.
    BMC Surg 2017 Jan 23;17(1). Epub 2017 Jan 23.
    Thoracic and Endocrine Surgery, University Hospitals of Geneva, 1211, Geneva, Switzerland.
    Background: To report the association between thoracic duct ligation and acute pancreatitis. The association between sudden stop of lymphatic flow and pancreatitis has been established in experimental models.

    Case Presentation: A 57-year-old woman operated for thymoma presented a iatrogenic chylothorax. Read More

    A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report.
    Diagn Pathol 2017 Jan 19;12(1):10. Epub 2017 Jan 19.
    Department of Pathology, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, 567 Baekje-daero, Dukjin-gu, Jeonju, 561-756, Republic of Korea.
    Background: Acinar cell carcinoma represents only 1-2% of exocrine pancreatic neoplasms. On exceptionally rare occasions, primary acinar cell carcinoma can occur in ectopic locations. Herein, we report a case of pure pancreatic-type acinar cell carcinoma arising in the stomach. Read More

    A rare case of metastasized non-functional pancreatic neuroendocrine tumor with a good long-term survival.
    J Med Life 2016 Oct-Dec;9(4):369-372
    "C. I. Parhon" National Institute of Endocrinology, Bucharest, Romania.
    Background: Non-functional neuroendocrine tumors of the pancreas (NF-pNETs) are a varied group of extremely rare malignancies. The majority of patients already have liver metastases at the diagnosis moment, thus, treatment options are restricted, and the survival rate is reserved. Case report: We presented the case of 59-year-old patient, diagnosed with non-functional well-differentiated pancreatic neuroendocrine tumor grade II (NET G2) with the presence of chromogranin A, synaptophysin and somatostatin receptor 2, together with liver and bone metastases. Read More

    Connexins and pannexins: from biology towards clinical targets.
    Swiss Med Wkly 2016 5;146:w14365. Epub 2016 Dec 5.
    Department of Medicine, Université de Lausanne, Lausanne, Switzerland.
    Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the extracellular medium, via membrane channels made of connexin and pannexin proteins. These channels are a necessary component of all human tissues. Read More

    Enucleation: A treatment alternative for branch duct intraductal papillary mucinous neoplasms.
    Surgery 2017 Mar 22;161(3):602-610. Epub 2016 Nov 22.
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Electronic address:
    Background: Small, asymptomatic, branch-duct intraductal papillary mucinous neoplasms of the pancreas are often kept under surveillance despite their malignant potential. The management of branch-duct intraductal papillary mucinous neoplasm is controversial with regard to indications and extent of any operative intervention. The present study aimed to evaluate enucleation as an alternative operative approach for branch-duct intraductal papillary mucinous neoplasms to exclude and prevent malignancy. Read More

    Giant insulinoma: report of a case and review of published reports.
    Surg Case Rep 2016 Dec 19;2(1):136. Epub 2016 Nov 19.
    Department of Surgery, Hitachi General Hospital, 2-1-1 Jonan-cho, Hitachi, Ibaraki, 317-0077, Japan.
    Background: Larger insulinomas are reportedly more likely to be malignant; however, their biological behavior has not been clearly elucidated. We here report the characteristics and treatment of a giant insulinoma with local invasion and lymph node metastasis. We also review published reports concerning the clinical features of giant insulinomas and comparing their grading with that of pancreatic neuroendocrine tumors. Read More

    A rare case with synchronous gastric gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and uterine leiomyoma.
    World J Surg Oncol 2016 Nov 15;14(1):287. Epub 2016 Nov 15.
    Department of General and Hepato-pancreatic Surgery, University Hospital "Alexandrovska"-Sofia, 1 Georgi Sofiiski Str, 1431, Sofia, Bulgaria.
    Background: Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. Read More

    Laparoscopic versus open distal pancreatectomy-a propensity score-matched analysis from the German StuDoQ|Pancreas registry.
    Int J Colorectal Dis 2017 Feb 4;32(2):273-280. Epub 2016 Nov 4.
    Clinic for Surgery, University Clinic Schleswig-Holstein, UKSH Campus Lübeck, 23538, Lübeck, Germany.
    Purpose: The aim of this study was to assess intraoperative, postoperative, and oncologic outcome in patients undergoing laparoscopic distal pancreatectomy (LDP) versus open distal pancreatectomy (ODP) for benign and malignant lesions of the pancreas.

    Methods: Data from patients undergoing distal pancreatic resection were extracted from the StuDoQ|Pancreas registry of the German Society for General and Visceral Surgery. After propensity score case matching, groups of LDP and ODP were compared regarding demography, comorbidities, operative details, histopathology, and perioperative outcome. Read More

    Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma.
    J Cancer Res Clin Oncol 2016 Dec 14;142(12):2585-2591. Epub 2016 Sep 14.
    Department of Internal Medicine III, Comprehensive Cancer Center, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Marchioninistr. 15, 81377, Munich, Germany.
    Purpose: Acinar cell carcinoma (ACC) of the pancreas is a very rare cancer, constituting 1 % of all malignant non-endocrine pancreatic tumors. Only very limited data exist to guide treatment in patients with advanced ACC.

    Methods: Between 2000 and 2015, 15 patients with ACC were diagnosed and/or treated at our high-volume comprehensive cancer center. Read More

    Clinical trials for BET inhibitors run ahead of the science.
    Drug Discov Today Technol 2016 Mar 21;19:45-50. Epub 2016 Jul 21.
    Department of Medicine, Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, United States; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA 02118, United States. Electronic address:
    Several cancer clinical trials for small molecule inhibitors of BET bromodomain proteins have been initiated. There is enthusiasm for the anti-proliferative effect of inhibiting BRD4, one of the targets of these inhibitors, which is thought to cooperate with MYC, a long-desired target for cancer therapeutics. However, no current inhibitor is selective for BRD4 among the three somatic BET proteins, which include BRD2 and BRD3; their respective functions are partially overlapping and none are functionally redundant with BRD4. Read More

    Parenchyma-sparing surgery for pancreatic endocrine tumors.
    Updates Surg 2016 Sep 5;68(3):313-319. Epub 2016 Oct 5.
    Pancreatic Surgery Unit-Hospital Health Direction, Humanitas Research Hospital, Rozzano, MI, Italy.
    Enucleation (EN) and middle pancreatectomy (MP) have been proposed as a treatment for G1 and G2 pancreatic neuroendocrine tumors (PNET). The aim of this study is to analyze the outcomes of parenchyma-sparing surgery (PSS) for PNET in an Italian high-volume center. All patients with a histological diagnosis of PNET who underwent surgical resection in our center between January 2010 and January 2016 were included in the study. Read More

    The Epidermal Growth Factor Receptor (EGFR) Inhibitor Gefitinib Reduces but Does Not Prevent Tumorigenesis in Chemical and Hormonal Induced Hepatocarcinogenesis Rat Models.
    Int J Mol Sci 2016 Sep 23;17(10). Epub 2016 Sep 23.
    Institut für Pathologie, Universitätsmedizin Greifswald, 17489 Greifswald, Germany.
    Activation of the epidermal growth factor receptor (EGFR) signaling pathway promotes the development of hepatocellular adenoma (HCA) and carcinoma (HCC). The selective EGFR inhibitor Gefitinib was found to prevent hepatocarcinogenesis in rat cirrhotic livers. Thus, Gefitinib might reduce progression of pre-neoplastic liver lesions to HCC. Read More

    Clinicopathological Features of Intraductal Papillary Mucinous Neoplasms of Pancreas in a Tertiary Care Center: A 14 Year Retrospective Study.
    J Clin Diagn Res 2016 Aug 1;10(8):EC10-3. Epub 2016 Aug 1.
    Assistant Professor, Department of Hepatopancreaticobiliary (HPB) Surgery, Christian Medical College Hospital , Vellore, Tamil Nadu, India .
    Introduction: Pancreatic surgeries are usually performed for inflammatory conditions and neoplasms. Intraductal Papillary Mucinous Neoplasm (IPMN) account for approximately 5-7% of all pancreatic neoplasms in western literature. To the best of our knowledge, there has been no published literature in Indian subcontinent on IPMN. Read More

    Comparison of postoperative early and late complications between pancreas-sparing duodenectomy and pancreatoduodenectomy.
    Surg Today 2017 Jun 21;47(6):705-711. Epub 2016 Sep 21.
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan.
    Purpose: Pancreas-sparing duodenectomy (PSD) represents an alternative procedure to pancreatoduodenectomy (PD) for patients with duodenal neoplasms.

    Methods: The postoperative early and late complications of 21 patients who underwent PSD between 1992 and 2014 were compared with those of 44 patients with soft pancreatic parenchyma who underwent PD between 2009 and 2014.

    Results: The median operation time and blood loss were less in the PSD group than in the PD group (P < 0. Read More

    Indications and results of pancreatic stump duct occlusion after duodenopancreatectomy.
    Updates Surg 2016 Sep 8;68(3):287-293. Epub 2016 Sep 8.
    Divisione di Chirurgia Digestiva, Fondazione Policlinico "A. Gemelli", Istituto di Clinica Chirurgica, Rome, Italy.
    Severe post-operative complications after pancreaticoduodenectomy (PD) are largely due to pancreatic fistula onset. The occlusion of the main pancreatic duct using synthetic glue may prevent these complications. Aim of this study is to describe this technique and to report short- and long-term results as well as the post-operative endocrine and exocrine insufficiency. Read More

    Survival variability of controls and definition of imaging endpoints for longitudinal follow-up of pancreatic ductal adenocarcinoma in rats.
    J Cancer Res Clin Oncol 2017 Jan 12;143(1):29-34. Epub 2016 Sep 12.
    IRCAD, University Hospital of Strasbourg, 1 place de l'hôpital, Strasbourg, France.
    Background: The 3Rs guideline is the gold standard for ethics in animal experimentation. Two of those rules, namely refinement and reduction, require further improvement. The objective of this study was to define pathways to better compliance with these prerequisites. Read More

    Endoscopic imaging in the management of gastroenteropancreatic neuroendocrine tumors.
    Minerva Endocrinol 2016 Dec;41(4):490-8
    Department of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy -
    Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors deriving from the gastrointestinal (GI) neuroendocrine system. Since these neoplasms are usually very small, located deeply within the retroperitoneum or into an extramucosal site of the GI tract and, lastly, because they may be multi-sited, radiological imaging modalities, in combination with endoscopy, are the diagnostic workhorses in patients with GEP-NETs. Endoscopic approach is useful for detection, bioptic diagnosis and curative resection of small GEP-NETs of stomach, duodenum, jejuno-ileum, and colon-rectum. Read More

    18F-DOPA PET/CT Physiological Distribution and Pitfalls: Experience in 215 Patients.
    Clin Nucl Med 2016 Oct;41(10):753-60
    From the *Neuroimaging Research Unit, Institute of Molecular Bioimaging and Physiology, IBFM-CNR, Italian National Research Council, Catanzaro; †Department of Biomedicine and Prevention, University "Tor Vergata," Rome; ‡Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila; Departments of §Neuroendocrinology, and ∥Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli, Isernia; ¶Radiation Oncology Unit, Sant' Andrea Hospital, University Sapienza, Rome, and IRCCS Neuromed, Pozzilli (IS), Italy; and **Department of Nuclear Medicine, Santa Maria Della Misericordia Hospital, Rovigo, Italy.
    Purpose: F-DOPA PET/CT is potentially helpful in the management of patients with low-grade brain tumors, movement disorders, and somatic neuroendocrine tumors. We describe the whole-body physiological distribution of F-DOPA uptake.

    Patients And Methods: We examined 215 patients with F-DOPA PET/CT. Read More

    Short- and long-term outcomes after enucleation of pancreatic tumors: An evidence-based assessment.
    Pancreatology 2016 Nov - Dec;16(6):1092-1098. Epub 2016 Jul 9.
    Department of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China.
    Background And Objective: Enucleation of pancreatic tumors is rarely performed. The aim of this study was to evaluate the published evidence for its short- and long-term outcomes.

    Methods: PubMed (MEDLINE) and EMBASE databases were searched from 1990 to March 2016. Read More

    Pancreatic neuroendocrine tumors: contemporary diagnosis and management.
    Hosp Pract (1995) 2016 Aug 18;44(3):109-19. Epub 2016 Jul 18.
    a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.
    Pancreatic neuroendocrine tumors (PNETs) are neoplasms that arise from the hormone producing cells of the islets of Langerhans, also known as pancreatic islet cells. PNETs are considered a subgroup of neuroendocrine tumors, and have unique biology, natural history and clinical management. These tumors are classified as 'functional' or 'non-functional' depending on whether they release peptide hormones that produce specific hormone- related symptoms, usually in established patterns based on tumor subtype. Read More

    Tyrosine Phosphorylation of Focal Adhesion Anchoring Proteins Enhances Human Pancreatic Cancer Cell Invasion.
    Pancreas 2016 08;45(7):e37-9
    Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan Department of Surgery Tsuru Municipal Hospital Tsuru, Japan Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan Department of Medical Oncology Shinko Hospital Kobe, Japan Department of Gastrointestinal Breast & Endocrine Surgery University of Yamanashi Faculty of Medicine Chuo, Japan.

    CD4(+) T cell-dominant insulitis in acute-onset Type 1 diabetes mellitus associated with intraductal papillary mucinous adenoma.
    Endocr J 2016 Sep 5;63(9):841-847. Epub 2016 Jul 5.
    Department of Internal Medicine, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tachikawa 190-8531, Japan.
    The loss of insulin-producing pancreatic β-cells in Type 1 diabetes mellitus (DM) is presumably the result of a T cell-mediated process. In general, CD8(+) T cells are the predominant lymphocytes in the insulitis lesions, and CD4(+) T cell-dominant insulitis is very rare. We present a case of a 72-year-old woman presented with excessive thirst and a 3-month history of weight loss. Read More

    Intraoperative portal vein insulin assay combined with occlusion of the pancreas for complex pancreatogenous hypoglycemia: Two cases report.
    Medicine (Baltimore) 2016 Jun;95(26):e3928
    Department of Hepatobiliary Surgery, China-Japan Friendship Hospital, Beijing, China.
    Intraoperative localization and confirmation of complete resection of the hypersecreting tissue are the 2 main challenges in the management of pancreatogenous hypoglycemia. Here, we report our experience with intraoperative portal vein insulin assay combined with occlusion of the pancreas in the management of pancreatogenous hypoglycemia. Clinical courses of 2 patients with biochemical evidence of a pancreatogenous hypoglycemia were studied. Read More

    The Selective Arterial Calcium Injection Test is a Valid Diagnostic Method for Invisible Gastrinoma with Duodenal Ulcer Stenosis: A Case Report.
    Hiroshima J Med Sci 2016 Mar;65(1):13-7
    The localization and diagnosis of microgastrinomas in a patient with multiple endocrine neoplasia type 1 is difficult preoperatively. The selective arterial calcium injection (SACI) test is a valid diagnostic method for the preoperative diagnosis of these invisible microgastrinomas. We report a rare case of multiple invisible duodenal microgastrinomas with severe duodenal stenosis diagnosed preoperatively by using the SACI test. Read More

    Complete metastasectomy for renal cell carcinoma: Comparison of five solid organ sites.
    J Surg Oncol 2016 Sep 23;114(3):375-9. Epub 2016 Jun 23.
    Urology Service, Memorial Sloan Kettering Cancer Center, New York, New York.
    Background And Objectives: Patients with metastatic RCC can undergo metastasectomy to improve survival time. Our goal was to provide and compare characteristics and oncological outcomes of RCC patients who underwent complete metastasectomy at a single organ site.

    Methods: A total of 138 RCC patients were identified as undergoing complete metastasectomy at a single organ site including adrenal, lung, liver, pancreas, or thyroid. Read More

    Single-centre experience of extending indications for percutaneous intraportal islet autotransplantation (PIPIAT) after pancreatic surgery to prevent diabetes: feasibility, radiological aspects, complications and clinical outcome.
    Br J Radiol 2016 Aug 21;89(1064):20160246. Epub 2016 Jun 21.
    1 Department of Radiology, San Raffaele Scientific Institute, Milan, Italy.
    Objective: Islet allotransplantation is a less invasive alternative to surgical pancreas transplantation for Type 1 diabetes, while percutaneous intraportal islet autotransplantation (PIPIAT) is usually performed after pancreatic surgery to prevent diabetes. Our aim was to assess the feasibility, radiological aspects, complications and clinical outcome of PIPIAT following pancreatic surgery for not only chronic pancreatitis but also benign and malignant nodules.

    Methods: From 2008 to 2012, 41 patients were enrolled for PIPIAT 12-48 h after pancreatic surgery (extended pancreatic surgery for chronic pancreatitis and benign/malignant neoplasms). Read More

    A rare case of three different tumors in the same pancreatic specimen: a case report and brief review of the literature.
    J Gastrointest Oncol 2016 Jun;7(3):E52-7
    1 Department of Gastroenterology B, 2 Unit of General and Pancreatic Surgery, Department of Surgery and Pathology, 3 ARC-NET Applied Research on Cancer Center, Department of Pathology and Diagnostics, 4 Department of Radiology, The Pancreas Institute, University and Hospital Trust of Verona, Verona, Italy.
    Solid pseudopapillary tumors (SPT) of the pancreas are rare neoplasms mainly affecting young women. Pancreatic serous cystadenomas (SCAs) and pancreatic neuroendocrine tumors (PanNETs) account for about 2% of all pancreatic neoplasms. The combination of these three lesions, to our knowledge, has never been described in literature. Read More

    Robot-assisted spleen preserving pancreatic surgery in MEN1 patients.
    J Surg Oncol 2016 Sep 6;114(4):456-61. Epub 2016 Jun 6.
    Department of Endocrine Surgical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Multiple Endocrine Neoplasia type 1 (MEN1) patients often undergo multiple pancreatic operations at a young age.

    Objective: To describe robot-assisted and laparoscopic spleen-preserving pancreatic surgery in MEN1 patients, and to compare both techniques.

    Methods: Robot-assisted pancreatectomies of the DutchMEN1 study group and the Université de Lorraine, Nancy, France were compared to a historical cohort of laparoscopic treated MEN1 patients. Read More

    [Management of gastrinoma].
    Presse Med 2016 Nov 1;45(11):986-991. Epub 2016 Jun 1.
    AP-HP, hôpital Cochin, service de chirurgie digestive hépato-biliaire et endocrienne, Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:
    Gastrinoma is a very rare tumor leading to gastrin hypersecretion and characterised by Zollinger-Ellisson syndrome (ZES) i.e. severe gastric and duodenal ulceration and profuse diarrhea. Read More

    Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma.
    J Korean Med Sci 2016 Jun 11;31(6):1003-6. Epub 2016 Apr 11.
    Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea .
    Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. Read More

    Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report.
    Transplant Proc 2016 Apr;48(3):988-90
    Division of Digestive and General Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
    Background: Long-term graft survival of partial pancreas auto-transplantation after total pancreatectomy has not been clarified. The clinical implications of repeat completion pancreatectomy for locally recurrent pancreatic carcinoma in the remnant pancreas after initial pancreatectomy also have not been clarified.

    Methods: We have previously reported a 61-year-old woman presenting with re-sectable carcinoma of the remnant pancreas at 3 years after undergoing a pylorus-preserving pancreaticoduodenectomy for invasive ductal carcinoma of the pancreas head. Read More

    Diabetes mellitus and pre-diabetes are frequently undiagnosed and underreported in patients referred for pancreatic surgery. A prospective observational study.
    Pancreatology 2016 Jul-Aug;16(4):671-6. Epub 2016 May 6.
    Department of Endocrinology, Diabetology and Metabolism, Antwerp University Hospital, Belgium.
    Objective: Previous reports on the prevalence of diabetes in pancreatic cancer and chronic pancreatitis patients are based on inconsistent and equivocal criteria. The objective of this study is to prospectively assess with conclusive methods the preoperative glycaemic status of patients undergoing pancreatic surgery. We hypothesise that most of those patients are unaware of these disturbances in glycaemic status and that the prevalence is underestimated. Read More

    [The biological role of sulfatides].
    Postepy Hig Med Dosw (Online) 2016 May 9;70:489-504. Epub 2016 May 9.
    Zakład Biochemii, Katedra Biochemii, Farmakologii i Toksykologii, Uniwersytet Przyrodniczy we Wrocławiu; Laboratorium Glikobiologii i Oddziaływań Międzykomórkowych, Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu.
    Sulfatides (3-O-sulfogalactosylceramides, sulfated galactocerebrosides, SM4) are esters of sulfuric acid with galactosylceramides. These acidic glycosphingolipids, present at the external leaflet of the plasma membrane, are synthesized by a variety of mammalian cells. They are especially abundant in the myelin sheath of oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Read More

    Using the Root of the Mesentery to Guide a Novel Operative Approach for Laparoscopic Insulinoma Resection.
    J Laparoendosc Adv Surg Tech A 2016 Jul 12;26(7):557-9. Epub 2016 May 12.
    General Department, QiLu Hospital of Shandong University , Jinan, China .
    Insulinoma is a functioning endocrine neoplasm appearing primarily in the tail and body of the pancreas, although it is also rarely found in the uncinate process. The sole treatment for insulinoma is surgical resection. However, for insulinoma in the uncinate process, traditional laparoscopic surgery is controversial owing to the fact that it is a complex operation and carries a high surgical risk. Read More

    Granulomatous Insulitis as a Cause of Acute-Onset Insulin-Dependent Diabetes Mellitus in a Patient With a Pancreatic Endocrine Carcinoma.
    Int J Surg Pathol 2016 Oct 8;24(7):648-52. Epub 2016 May 8.
    New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY, USA
    Autoimmune destruction of β cells is the cause of most cases of type 1 diabetes mellitus. Lymphocytic insulitis has been documented in the early phases of this disease as well as in recurrent diabetes after pancreas transplantation and in certain viral infections. We report a unique case of granulomatous insulitis in a patient with an endocrine tumor of the pancreas that clinically manifested as acute-onset insulin-dependent diabetes mellitus. Read More

    Multiple Endocrine Neoplasia Syndromes: A Comprehensive Imaging Review.
    Radiol Clin North Am 2016 May 10;54(3):441-51. Epub 2016 Mar 10.
    Division of Abdominal Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, White 270, Boston, MA 02114, USA.
    MEN1, MEN2, and MEN4 comprise a series of familial disorders involving the simultaneous occurrence of tumors in more than one endocrine organ, collectively known as multiple endocrine neoplasia. Patients with this family of disorders develop tumors of the parathyroid gland, pancreas, pituitary gland, adrenal gland, and thyroid gland, along with miscellaneous neuroendocrine tumors of the respiratory and gastrointestinal tracts. Although some patients undergo early prophylactic surgical management, particularly in the setting of familial medullary thyroid carcinoma, many develop tumors later in life. Read More

    [Surgical experience on Roux-en-Y pancreaticojejunostomy after local pancreatic head resection for benign tumors of the pancreatic head].
    Zhonghua Wai Ke Za Zhi 2016 May;54(5):376-9
    Department of General Surgery, Peking University Third Hospital, Beijing 100191, China.
    Objective: To explore the value of Roux-en-Y pancreaticojejunostomy after local pancreatic head resection in treating benign tumors of pancreatic head (BTPH).

    Methods: The clinical data of 12 patients diagnosed as BTPH and treated by Roux-en-Y pancreaticojejunostomy after local pancreatic head resection in Department of General Surgery, Peking University Third Hospital from November 2006 to October 2013 were retrospectively analyzed.Of the 12 cases, 5 patients were male, 7 patients were female, the age of patients ranged from 21 to 64 years(average 42. Read More

    EUS - Fine- Needle Aspiration Biopsy (FNAB) in the Diagnosis of Pancreatic Adenocarcinoma: A Review.
    Rom J Intern Med 2016 Jan-Mar;54(1):24-30
    Solid masses of the pancreas represent a variety of benign and malignant neoplasms of the exocrine and endocrine tissues of the pancreas. A tissue diagnosis is often required to direct therapy in the face of uncertain diagnosis or if the patient is not a surgical candidate either due to advanced disease or comorbidities. Endoscopic ultrasound (EUS) is a relatively new technology that employs endoscopy and high-frequency ultrasound (US). Read More

    Recent Updates on Neuroendocrine Tumors From the Gastrointestinal and Pancreatobiliary Tracts.
    Arch Pathol Lab Med 2016 May;140(5):437-48
    From the Department of Pathology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea (Dr Kim); and the Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea (Dr Hong).
    Context: -Gastrointestinal (GI) and pancreatobiliary tracts contain a variety of neuroendocrine cells that constitute a diffuse endocrine system. Neuroendocrine tumors (NETs) from these organs are heterogeneous tumors with diverse clinical behaviors. Recent improvements in the understanding of NETs from the GI and pancreatobiliary tracts have led to more-refined definitions of the clinicopathologic characteristics of these tumors. Read More

    An autoregulatory network between menin and pri-miR-24-1 is required for the processing of its specific modulator miR-24-1 in BON1 cells.
    Mol Biosyst 2016 May;12(6):1922-8
    Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy.
    Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions. MEN1 is characterized by tumours of the parathyroids, of the neuroendocrine cells of the gastroenteropancreatic tract, and of the anterior pituitary. The MEN1 gene, a tumour suppressor gene, encodes the menin protein. Read More

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