Search Our Scientific Publications & Authors

Acta Biomed 2021 May 12;92(2):e2021107. Epub 2021 May 12.

PEDIATRICIAN ONCOLOGIST.

Ependymomas are glial neoplasms of central nervous system originated from the ependymal lining of the brain ventricles and spinal cord central canal, and rarely exfoliated into cerebrospinal fluid (CSF). In this case we report the cytomorphological and immunocytomorphological features of ependymoma in CSF and intraoperative squash preparations, confirmed by histology. Case report. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):486-492

Dept. of Thoracic Oncology, Kobe Minimally Invasive Cancer Center.

Small cell lung cancer(SCLC)frequently develops both brain metastases and bone metastases. Considering the negative effects on quality of life(QOL), it is essential to manage properly these metastases. In patients with limited‒disease(LD) SCLC who have a good response to chemoradiotherapy, prophylactic cranial irradiation(PCI)is given to decrease brain metastases. Read More

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan

A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Read More

Surg Neurol Int 2021 8;12:145. Epub 2021 Apr 8.

Department of Orthopaedic, Spine Division, P.D. Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India.

Background: Intradural extramedullary spinal cord tumors (IESCT) account for approximately two-thirds of largely benign intraspinal neoplasms. They occasionally present with acute neurological deterioration warranting emergent surgical intervention.

Methods: Here, we reviewed a series of 31 patients with intradural extramedullary spinal tumors who underwent surgery from 2012 to 2019. Read More

BMJ Case Rep 2021 May 4;14(5). Epub 2021 May 4.

Neurology Department, Morriston Hospital, Swansea, UK.

Neuromyelitis optica spectrum disorder (NMOSD) is an uncommon antibody-mediated disease of the central nervous system, often associated with aquaporin-4 antibodies (AQP4-Ab). NMOSD may present as a subacute myelopathy, progressing over days with MRI revealing a contiguous inflammatory lesion of the spinal cord, ≥3 vertebral segments, a longitudinally extensive transverse myelitis. We describe an unusual paraneoplastic form of AQP4-Ab NMOSD that developed in a patient with an advanced diffuse large B-cell lymphoma. Read More

J Pak Med Assoc 2021 Feb;71(2(B)):775-777

Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.

Paediatric intramedullary spinal cord lesions are uncommon pathologies, prone to result in dismal prognosis if not managed promptly and aggressively. While children usually present in good functional grades compared to adults, early recognition and treatment is important to improve outcomes. In this review, we present tumour demographics, patient factors, and treatment modalities of intramedullary spinal cord lesions in paediatric patients. Read More

Bone Joint J 2021 May;103-B(5):971-975

Royal Orthopaedic Hospital, Birmingham, UK.

Aims: The aim of this study was to assess the reliability of using MRI scans to calculate the Spinal Instability Neoplastic Score (SINS) in patients with metastatic spinal cord compression (MSCC).

Methods: A total of 100 patients were retrospectively included in the study. The SINS score was calculated from each patient's MRI and CT scans by two consultant musculoskeletal radiologists (reviewers 1 and 2) and one consultant spinal surgeon (reviewer 3). Read More

Neurosurg Focus 2021 May;50(5):E18

1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

Objective: Primary spinal meningiomas represent a rare indolent neoplasm usually situated in the intradural-extramedullary compartment. They have a predilection for afflicting the thoracic spine and most frequently present with sensory and/or motor symptoms. Resection is the first-line treatment for symptomatic tumors, whereas other clinical factors will determine the need for adjuvant therapy. Read More

Int J Mol Sci 2021 Apr 10;22(8). Epub 2021 Apr 10.

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics, such as oxaliplatin (L-OHP). The aim of the present work was to evaluate the potential beneficial effects of 2-pentadecyl-2-oxazoline (PEA-OXA) in a murine model of oxaliplatin-induced peripheral neuropathy (OIPN). OIPN was induced by an intraperitoneally injection of L-OHP in rats on five consecutive days (D0-4) for a final cumulative dose of 10 mg/kg. Read More

Pan Afr Med J 2021 4;38:128. Epub 2021 Feb 4.

Service de Neurochirurgie du Centre Hospitalier Universitaire Yalgado Ouédraogo de Ouagadougou, Ouagadougou, Burkina Faso.

Intraspinal tumors are uncommon. Positive diagnosis is based on medical imaging exams, in particular MRI. Anatomopathological examination allows for definitive diagnosis. Read More

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

Medical Oncology, Cork University Hospital, Cork, Ireland.

A 59-year-old man with a known breast cancer type 1 gene mutation and a 2-year history of metastatic prostate cancer to bone and lymph nodes presented with a sudden onset of thunderclap headache, photophobia and a left sided facial droop. He was being treated at the time with the poly ADP ribose polymerase inhibitor Rucaparib. Of note, 6 weeks prior to this presentation, he had been diagnosed with malignant spinal cord compression at T3-T6, he underwent an emergency decompressive laminectomy and had received palliative postoperative radiotherapy. Read More

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):17-25

Voino-Yasenetsky Research and Practical Center for Specialized Medical Care, Moscow, Russia.

The purpose of this study was to assess the influence of resection quality on overall survival and disease-free survival in children with atypical teratoid-rhabdoid tumors (ATRT). The study included children younger than 18 years old for the period from 2008 to 2019. There were 134 interventions in 105 patients with ATRT including 11 redo resections («second-look» surgery) and 18 procedures for tumor recurrence. Read More

J Korean Neurosurg Soc 2021 Apr 16. Epub 2021 Apr 16.

Division of Pediatric Neurosurgery, Department of Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objective: Few studies exist on primary spinal cord tumors (PSCTs) in pediatric patients. The purpose of this study was to perform descriptive analysis and detailed survival analysis for PSCTs.

Methods: Between 1985 and 2017, 126 pediatric patients (male : female, 56 : 70) with PSCTs underwent surgery in a single institution. Read More

Nat Commun 2021 04 12;12(1):2184. Epub 2021 Apr 12.

Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, WC1E 6DD, UK.

Glioblastomas are hierarchically organised tumours driven by glioma stem cells that retain partial differentiation potential. Glioma stem cells are maintained in specialised microenvironments, but whether, or how, they undergo lineage progression outside of these niches remains unclear. Here we identify the white matter as a differentiative niche for glioblastomas with oligodendrocyte lineage competency. Read More

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Department of Orthopaedic Surgery, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia.

Anaesthesia for patients with huge mediastinal mass is very challenging due to the cardiorespiratory embarrassment that may occur. We present a patient with this condition, which was complicated by total airway obstruction, intraoperatively. We discuss the importance of patient positioning and the role of spontaneous ventilation. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Mar;35(3):224-228

Department of Otolaryngology Head and Neck Surgery，Affiliated Hospital of Qingdao University，Qingdao，266003，China.

To explore the therapeutic effect and prognostic risk factors of olfactory neuroblastoma. Retrospective analysis of clinical data of 31 patients with olfactory neuroblastoma. The Kaplan-Meier method was used for survival analysis to calculate the overall survival rate and progress-free survival rate. Read More

Neurohospitalist 2021 Apr 16;11(2):170-174. Epub 2020 Oct 16.

Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA.

Primary central nervous system lymphoma (PCNSL) is an uncommon variant of extra-nodal non-Hodgkin's lymphoma. Three regions can be involved in PCNSL: the brain, the spine, or the vitreus and retina. Spinal PCNSL is rare. Read More

J Clin Neurosci 2021 Apr 1;86:79-84. Epub 2021 Feb 1.

Department of Neurological Surgery, University of Virginia Health System, Charlottesville, VA, USA.

Neurofibromatosis type 2 (NF2) is a rare, hereditary tumor syndrome, often requiring repeated surgeries for multiple lesions with significant cumulative morbidity. As such, non-operative management should be considered when possible for this patient population. The aim of this study is to provide a systematic review of the literature regarding this treatment strategy. Read More

Nervenarzt 2021 Apr 25;92(4):293-306. Epub 2021 Mar 25.

Experimental and Clinical Research Center, Max Delbrück Center for Molecular Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Berlin, Deutschland.

Myelitis is an acute or subacute inflammatory syndrome of the spinal cord. Myelopathy, often used as a synonym and presenting with similar symptoms in clinical practice, can be caused by numerous, not primarily inflammatory etiologies and might also show a progressive disease course. Within the last decade the spectrum of autoimmune myelitis was significantly broadened as was the spectrum of diagnostic methods. Read More

BMJ Case Rep 2021 Mar 19;14(3). Epub 2021 Mar 19.

Medicine, East Sussex Healthcare NHS Trust, Saint Leonards-on-Sea, UK.

Plasmablastic myeloma is a rare variant of multiple myeloma characterised by neoplastic proliferation of single clone of plasma cells producing monoclonal immunoglobulins. A 60-year-old man presented to hospital with a 6-week history of chest pain, back pain, leg weakness and numbness. Imaging revealed a 75 mm left lobular lung mass with chest wall invasion, metastatic bony and soft-tissue deposits and spinal cord compression at T5 level. Read More

BMJ Case Rep 2021 Mar 17;14(3). Epub 2021 Mar 17.

Department of Neurology, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Superficial siderosis is a rare disorder characterised by the deposition of haemosiderin on the surface of the central nervous system. Cognitive dysfunction has sporadically been reported in relation with superficial siderosis. We present a 61-year-old man with cognitive dysfunction in the presence of the typical radiological image of temporal and cerebellar superficial siderosis, most likely due to pseudomeningocoele 14 years after resection of a meningioma at the cervicothoracic junction. Read More

J Int Med Res 2021 Mar;49(3):300060521999566

Department of Pathology, Inje University School of Medicine, Busan Paik Hospital, Busan, Republic of Korea.

Chordomas are rare, locally aggressive bone malignancies with poor prognoses. However, those with minimal or no bone involvement are more easily resectable because of their well-delineated margins and thus have better prognoses. Such extraosseous chordomas of the spine are localized both intradurally and extradurally. Read More

Cancer Treat Rev 2021 Mar 19;94:102168. Epub 2021 Feb 19.

Department of Medical Oncology, ENETS Centre of Excellence, The Christie NHS Foundation Trust, Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. Electronic address:

Objective: This systematic review and meta-analysis aimed to develop an evidence-based summary of current knowledge of bone metastases (BMs) in neuroendocrine neoplasms (NENs), inform diagnosis and treatment and standardise management between institutions.

Methods: PubMed, Medline, EMBASE and meeting proceedings were searched for eligible studies reporting data on patients with BMs and NENs of any grade of differentiation and site; poorly-differentiated large/small cell lung cancer were excluded. Data were extracted and analysed using STATA v. Read More

Brain 2021 03;144(2):357-360

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

J Neuroimmunol 2021 04 20;353:577523. Epub 2021 Feb 20.

Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, USA; West Virginia Clinical Transitional Science, Morgantown, WV, USA. Electronic address:

Objective: To report a unique case and literature review of post COVID-19 associated transverse myelitis and dysautonomia with abnormal MRI and CSF findings.

Background: Coronavirus disease have been reported to be associated with several neurological manifestations such as stroke, Guillain-Barré syndrome, meningoencephalitis amongst others. There are only few reported cases of transverse myelitis with the novel coronavirus (n-CoV-2) and only one reported case identifying dysautonomia in COVID-19 patient. Read More

Travel Med Infect Dis 2021 Mar-Apr;40:102000. Epub 2021 Feb 25.

Emergency Neurology Unit, IRCCS C. Mondino Foundation, Pavia, Italy.

Brain Behav 2021 Apr 27;11(4):e02020. Epub 2021 Feb 27.

Department of Neurology, Tokushima University Hospital, Tokushima, Japan.

Background: Transection-induced axonal retrograde degeneration, in contrast to Wallerian degeneration, has not been widely recognized in clinical practice.

Aims Of The Study: To assess a potential of corticospinal tractography for detecting axonal retrograde degeneration.

Methods: We assessed the corticospinal tractography of a 74-year-old woman with monoplegia of the lower limb due to a unilateral thoracic spinal cord tumor. Read More

Acta Ortop Mex 2020 Sep-Oct;34(5):293-297

Neurosurgery Department. Hospital Regional de Alta Especialidad del Bajío, Universidad de Guanajuato. León, Gto., México.

Introduction: Multiple myeloma represents 1% of all cancers and 10% of hematological cancers. Up to 80-90% of cases will have skeletal involvement and the spine is the most frequently involved site. Any intervention must be aimed to improve the patients functional prognosis and will impact their quality of life. Read More

Neuroepidemiology 2021 25;55(2):109-118. Epub 2021 Feb 25.

Department of Neuropsychiatry, Assiut University Hospital, Faculty of Medicine, Aswan, Egypt.

Background: COVID-19 can be accompanied by acute neurological complications of both central and peripheral nervous systems (CNS and PNS). In this study, we estimate the frequency of such complications among hospital inpatients with COVID-19 in Assiut and Aswan university hospitals.

Materials And Methods: We screened all patients with suspected COVID-19 admitted from 1 June to 10 August 2020 to the university hospitals of Assiut and Aswan in Upper Egypt. Read More

An Bras Dermatol 2021 Mar-Apr;96(2):184-187. Epub 2021 Feb 4.

Dermatology Service, CES University, Medellín, Antioquia, Colombia.

Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper respiratory tract and skin, the latest with few cases reported in the literature and related with human immunodeficiency virus infection and acquired immune deficiency syndrome. The authors present the first case of a Colombian adult patient with human immunodeficiency virus infection and multifocal Epstein Barr virus-associated smooth muscle tumors in the skin and epidural region, confirmed by histopathology, immunohistochemistry and in situ hybridization studies. Read More