Search Our Scientific Publications & Authors

Indian J Pathol Microbiol 2022 May;65(Supplement):S125-S134

Department of Pathology and Lab Medicine, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Diagnosis of central nervous system (CNS) granulomas is challenging. The etiology may be infectious or non-infectious. The infectious causes are due to mycobacteria, fungi, parasites and rarely bacteria. Read More

World Neurosurg 2022 May 9. Epub 2022 May 9.

Subdirection of basic research, Instituto Nacional de Cancerología. San Fernando Avenue 22, Belisario Domínguez Sección XVI. México City 14080, México. Electronic address:

Benign tumors that grow in the spinal canal are heterogeneous neoplasms with low incidence; from these, meningiomas and nerve sheath tumors (neurofibromas and schwannomas) account for 60% to 70% of all primary spinal tumors. Benign spinal canal tumors provoke nonspecific clinical manifestations, mostly related to the affected level of the spinal cord. These tumors present a challenge for the patient and healthcare professionals for they are often difficult to diagnose, and the high frequency of posttreatment complications. Read More

BMJ Case Rep 2022 May 10;15(5). Epub 2022 May 10.

Monash Imaging, Monash Health, Clayton, Victoria, Australia.

Spinal Cord Ser Cases 2022 May 9;8(1):51. Epub 2022 May 9.

Northwest Regional Spinal Injuries Centre, District General Hospital, Southport, PR8 6PN, UK.

Introduction: Chronic irritation caused by urinary catheter may predispose to metaplastic changes in the bladder and very rarely, nephrogenic metaplasia.

Case Presentation: A 53-year-old lady with T-2 paraplegia and urethral catheter drainage for 27 years presented with haematuria. MRI of pelvis, performed seven years ago, showed a 10 cm intramural fibroid within the anterior aspect of the uterine body which was pushing the collapsed urinary bladder containing the Foley catheter to the left. Read More

J Radiol Case Rep 2022 Mar 1;16(3):15-22. Epub 2022 Mar 1.

Anatomical Pathology Department, Faculty of Medicine, Universitas Airlangga, Indonesia.

Intramedullary cavernous angioma is a rare vascular malformation compared to cerebral cavernous malformation. The incidence of cavernous angioma is about 3 - 5% of all central nervous system lesions, 5 - 12% of all spinal vascular lesions, and 1% of all intramedullary lesions in pediatric patients. Although intramedullary cavernous angioma has the same histological picture as cerebral cavernous angioma, the natural history, and surgical approach are different from cerebral cavernous angioma. Read More

Radiat Oncol 2022 May 7;17(1):86. Epub 2022 May 7.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Purpose: This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 metastases) with a conventional C-arm linear accelerator.

Materials And Methods: This study retrospectively analyzed 10 patients with multiple brain metastases (40-120 metastases, median 76), who underwent WBRT and SIB using helical tomotherapy (HT). The prescribed doses were 40 Gy/20 f and 60 Gy/20 f for WBRT and SIB, respectively. Read More

Dis Markers 2022 25;2022:9978282. Epub 2022 Apr 25.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, Anhui Province, China.

Nasopharyngeal carcinoma (NPC) is a clinically multiple malignant tumor. At present, with the increase in the infection rate of Epstein-Barr virus, the incidence of nasopharyngeal carcinoma is also increasing day by day. To explore the effect of body size change on off-center cervical point and face doses in patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy, in total, 100 patients with NPC from January 2019 to May 2020 in our hospital were selected for retrospective analysis, and they all received intensity-modulated radiation therapy. Read More

Surg Neurol Int 2022 22;13:160. Epub 2022 Apr 22.

Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.

Background: Primary spinal glioblastomas are extremely rare neoplasms and account for only 0.2% of glioblastoma cases. Due to the rare incidence of spinal cord glioblastoma in the literature, its natural history/ outcome remains undetermined. Read More

Indian J Ophthalmol 2022 05;70(5):1828-1831

Department of Ophthalmology, Yildirim Beyazit University, Ankara, Turkey.

Neuromyelitis optica (NMO), also known as Devic's disease, is a rare, autoimmune, and recurrent demyelinating disorder that primarily affects the spinal cord and optic nerve. We report a case with recurrent optic neuritis caused by the paraneoplastic NMO spectrum disorder in the setting of a gastric neuroendocrine tumor 2 weeks after receiving an inactive COVID-19 vaccine. Read More

J Pathol Transl Med 2022 May 3. Epub 2022 May 3.

Department of Laboratory Medicine and Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA.

Hemangioblastoma is a benign, highly vascularized neoplasm of the central nervous system (CNS). This tumor is associated with loss of function of the VHL gene and demonstrates frequent occurrence in von Hippel-Lindau (VHL) disease. While this entity is designated CNS World Health Organization grade 1, due to its predilection for the cerebellum, brainstem, and spinal cord, it is still an important cause of morbidity and mortality in affected patients. Read More

Iran J Child Neurol 2022 14;16(2):129-135. Epub 2022 Mar 14.

Pediatric Neurology Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Spinal cord tumors are rare in children, mostly presented with unspecific symptoms that might pose a problem due to their possible malignancy and further complications. However, there are limited data on spinal cord lesions in Iran. This study aimed to present a series of 37 cases of primary spinal tumors treated at the same institution and briefly review their pathology, symptoms, and site of occurrence. Read More

Am J Case Rep 2022 May 1;23:e936283. Epub 2022 May 1.

Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USA.

BACKGROUND Neuromyelitis optica (NMO) is a rare neurological disease characterized by attacks of transverse myelitis and optic neuritis, contiguous spinal cord lesions on more than 3 vertebral segments on magnetic resonance imaging (MRI), and seropositivity for AQP-4 Ab. The tissue destruction from NMO is immune mediated and results in demyelination and axonal damage. Optic and spinal nerve involvement can eventually lead to blindness, weakness, and altered consciousness, and bladder and bowel involvement in some cases. Read More

Zhonghua Yi Xue Za Zhi 2022 May;102(17):1311-1314

Department of Diagnostic Radiology, Nanjing 210002, China.

The retrospective study included 122 cases of multiple glioma and 183 cases of single glioma. Of these, there were 74 males and 48 female with multiple gliomas, aged 18 to 83 (53±13) years, and 104 males and 79 females with single gliomas, aged 10 to 84 (51±14) years. A standard spatial-based lesion analysis method was used for constructing a spatially distributed frequency heatmap of multiple gliomas, to observe the characteristics of their white matter invasion sites. Read More

J Neuroinflammation 2022 Apr 29;19(1):102. Epub 2022 Apr 29.

Department of Immunology and Infection, Biomedical Research Institute, Hasselt University, 3590, Diepenbeek, Belgium.

Background: Spinal cord injury (SCI) elicits a robust neuroinflammatory reaction which, in turn, exacerbates the initial mechanical damage. Pivotal players orchestrating this response are macrophages (Mφs) and microglia. After SCI, the inflammatory environment is dominated by pro-inflammatory Mφs/microglia, which contribute to secondary cell death and prevent regeneration. Read More

Strahlenther Onkol 2022 Apr 29. Epub 2022 Apr 29.

Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, 130021, Changchun, China.

Purpose: The purpose of this study is to investigate the effect of plan complexity on the dosimetry, delivery accuracy, and interplay effect in lung stereotactic body radiation therapy (SBRT) using volumetric modulated arc therapy (VMAT) with 6 MV flattening-filter-free (FFF) beam.

Methods: Twenty patients with early stage non-small cell lung cancer were included. For each patient, high-complexity (HC) and low-complexity (LC) three-partial-arc VMAT plans were optimized by adjusting the normal tissue objectives and the maximum monitoring units (MUs) for a Varian TrueBeam linear accelerator (Varian Medical Systems, Palo Alto, CA, USA) using 6 MV FFF beam. Read More

Acta Neuropathol Commun 2022 Apr 28;10(1):64. Epub 2022 Apr 28.

Department of Pathology and Cell Biology, Columbia University Irving Medical Center, 1130 St. Nicholas Avenue, New York, NY, 10032, USA.

We present the case of a 41-year-old man who developed worsening mid-thoracic back pain and imaging revealed a well-circumscribed intramedullary tumor in the thoracic spinal cord. Subtotal resection was performed, and histopathological analysis showed a cytologically bland, minimally proliferative glial neoplasm. Sequencing revealed H3 K27M and an activating PTPN11 mutation. Read More

Glia 2022 Jul 26;70(7):1426-1449. Epub 2022 Apr 26.

Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Genetic mutations that cause amyotrophic lateral sclerosis (ALS), a progressively lethal motor neuron disease, are commonly found in ubiquitously expressed genes. In addition to direct defects within motor neurons, growing evidence suggests that dysfunction of non-neuronal cells is also an important driver of disease. Previously, we demonstrated that mutations in DNA/RNA binding protein fused in sarcoma (FUS) induce neurotoxic phenotypes in astrocytes in vitro, via activation of the NF-κB pathway and release of pro-inflammatory cytokine TNFα. Read More

J Clin Neurosci 2022 Jun 23;100:148-154. Epub 2022 Apr 23.

Department of Neurosurgery, Spine and Spinal Cord Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; POSTECH Biotech Center, Pohang University of Science and Technology, Pohang, Gyeongbuk, Korea.

Objective: To investigate the incidence of cervical spine deformity and instability after posterior cervical spinal cord tumor (CSCT) resection without fusion or fixation in adults and examine relevant risk factors by reviewing and summarizing previously reported studies.

Methods: We selected peer reviewed articles published between January 1990 and December 2020 from the MEDLINE and Cochrane Library databases using relevant key words. Articles in which the authors mainly described spinal cord tumor resection through posterior surgery without fusion or fixation in adults were selected for analysis. Read More

J Ayub Med Coll Abbottabad 2022 Jan-Mar;34(1):183-191

Baqai Medical University, Karachi, pakistan.

Background: The spinal column is a major site of neoplastic proliferation where decisions regarding surgical or radiotherapeutic intervention are based upon spinal instability neoplastic score (SINS). A novel technique named 'Intraoperative radiotherapy (IORT) was proposed where surgery and radiotherapy were performed in the same session. During our literature search, we found no published systematic review or meta-analysis regarding the outcomes of IORT for spinal tumors. Read More

J Chiropr Med 2021 Sep 6;20(3):170-175. Epub 2022 Apr 6.

Department of Neurosurgery, Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.

Objective: The purpose of this case report is to describe the presentation of a patient with bilateral lumbar radiculopathy secondary to myxopapillary ependymoma.

Clinical Features: A 45-year-old man presented to a chiropractic office for evaluation and treatment of chronic lower back pain with bilateral lower extremity radiation. The initial onset of pain was related to a lifting injury 6 years prior that never fully resolved. Read More

Klin Onkol 2022 ;35(2):94-99

Background: Acupuncture is one of the oldest therapeutic methods. The traditional view of acupuncture is represented by influencing energy pathways through stimulation of specific points. The original meridian theory, which works with the assumption of normalization of the flowing energy Qi in the organism is, with increasing evidence, supplemented with information about the bio-logical impact of the use of acupuncture from the perspective of Western medicine. Read More

Spinal Cord Ser Cases 2022 Apr 22;8(1):43. Epub 2022 Apr 22.

Department of Neurological Surgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.

Introduction: Spinal myxopapillary ependymomas (SME) are rare WHO grade II neoplasms of the spinal cord. Despite their good prognosis, they have a high propensity for metastasis and recurrence, although the presentation of SME as multifocal is uncommon.

Case Presentation: Here we describe a rare case of a 34-year-old man who presented with painful bilateral radiculopathy with sexual dysfunction and altered sensation with defecation. Read More

JCI Insight 2022 Apr 22;7(8). Epub 2022 Apr 22.

Department of Immunology, Duke University School of Medicine, Durham, North Carolina, USA.

Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory responses through their effector cytokines, IL-1β and IL-18. Multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), are autoimmune conditions influenced by inflammasomes. Read More

J Int Med Res 2022 Apr;50(4):3000605221091665

Department of Orthopaedics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

The treatment for spinal metastasis has evolved significantly during the past decade. An advancement in systemic therapy has led to a prolonged overall survival in cancer patients, thus increasing the incidence of spinal metastasis. In addition, with the improved treatment armamentarium, the prediction of patient survival using traditional prognostic models may have limitations and these require the incorporation of some novel parameters to improve their prognostic accuracy. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):315-319

Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and key technology of microscopic resection of lumbar intraspinal tumor through microchannel keyhole approach.

Methods: The clinical features, imaging characteristics and surgical methods of 54 cases of lumbar intraspinal tumor which were microscopically operated by microchannel from February 2017 to September 2019 were reviewed and analyzed. There were 8 cases of extradural tumor, 3 cases of extra-and intradural tumor and 43 cases of subdural extramedullary tumor (including 3 cases of ventral spinal tumor). Read More

Arch Esp Urol 2022 04;75(3):308-309

Especialista en Medicina Familiar y Comunitaria. Centro de Salud de Los Llanos de Aridane. Santa Cruz de Tenerife España.

Case Rep Oncol 2022 Jan-Apr;15(1):163-169. Epub 2022 Mar 3.

Department of Medical Oncology, Mie University Hospital, Tsu, Japan.

Undifferentiated neoplasms of unknown primary sites are rare. It is difficult to identify their characteristics and determine the appropriate chemotherapy regimen to be used. Undifferentiated/rhabdoid carcinoma is reportedly associated with loss of SWI/SNF chromatin remodeling complexes, such as observed in SMARCA4-deficient tumors. Read More

Neurohospitalist 2022 Apr 21;12(2):273-275. Epub 2021 Sep 21.

Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.

This article characterizes 2 cases of longitudinally extensive transverse myelitis (LETM) that did not respond to immunotherapy and were diagnosed by biopsy as primary central nervous system (CNS) malignancies. Diffuse H3 K27M-mutant glioma is a recently described entity with very few cases of isolated spinal disease described in adults. Primitive neuroectodermal tumor is similarly uncommon in the spinal cord. Read More

Future Oncol 2022 Jun 13;18(18):2257-2267. Epub 2022 Apr 13.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.

This retrospective, observational study evaluated the long-term (>12 months) safety and effectiveness of bisphosphonate. Data collected for 359 patients included quantity and proportion of adverse events (AEs) and skeletal-related events (SREs), and times to first AE and first SRE. Patients in the ≤24-month group experienced significantly fewer AEs compared with the >24-month treatment group (p = 0. Read More

Breast 2022 Jun 2;63:149-156. Epub 2022 Apr 2.

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA. Electronic address:

Patients with metastatic breast cancer are at high risk for developing vertebral compression fractures due to underlying bone metastases and bone density loss. Vertebral augmentation techniques including percutaneous vertebroplasty and percutaneous balloon kyphoplasty are techniques used to stabilize compression fractures and improve pain. However, rare complications from these interventions have been observed, including spinal cord compression, nerve root compression, venous cement embolism, and pulmonary cement embolism. Read More