Search Our Scientific Publications & Authors

Eur Radiol 2021 May 15. Epub 2021 May 15.

Department of Radiology, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, Villejuif, 94800, Paris, France.

Objectives: Vertebral invasion is a key prognostic factor and a critical aspect of surgical planning for superior sulcus tumors. This study aims to further evaluate MRI features of vertebral invasion in order to distinguish it from reactive inflammatory changes.

Methods: Between 2000 and 2016, a retrospective study was performed at a single institution. Read More

Int J Cancer 2021 May 14. Epub 2021 May 14.

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

Cancer stage at diagnosis is important information for management and treatment of individual patients as well as in epidemiological studies to evaluate effectiveness of health care system in managing cancer patients. Population-based studies to examine international disparities on cancer survival by stage, however, has been challenging due to the lack of international standardization on recording stage information and variation in stage completeness across regions and countries. The International Cancer Benchmarking Partnership (ICBP) previously assessed the availability and comparability of staging information for colorectal, lung, female breast, and ovarian cancers. Read More

Sci Rep 2021 May 13;11(1):10252. Epub 2021 May 13.

Department of Neuroscience and Pharmacology, University of Iowa, 2-570 Bowen Science Building, 51 Newton Road, Iowa City, IA, 52242, USA.

Pancreatic neuroendocrine neoplasms (pNENs) are slow growing cancers of increasing incidence that lack effective treatments once they become metastatic. Unfortunately, nearly half of pNEN patients present with metastatic liver tumors at diagnosis and current therapies fail to improve overall survival. Pre-clinical models of pNEN metastasis are needed to advance our understanding of the mechanisms driving the metastatic process and for the development of novel, targeted therapeutic interventions. Read More

BMC Med Imaging 2021 May 13;21(1):81. Epub 2021 May 13.

Department of Radiology, University of Chinese Academy of Sciences Chongqing Renji Hospital (Fifth People's Hospital of Chongqing), No. 24 Renji Road, Nan'an District, Chongqing, China.

Background: Necrotic pulmonary lesions manifest as relatively low-density internally on contrast-enhanced computed tomography (CT). However, using CT to differentiate malignant and benign necrotic pulmonary lesions is challenging, as these lesions have similar peripheral enhancement. With the introduction of dual-energy spectral CT (DESCT), more quantitative parameters can be obtained and the ability to differentiate material compositions has been highly promoted. Read More

BMC Cancer 2021 May 13;21(1):547. Epub 2021 May 13.

Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), CONICET and Hospital de Clínicas Gral. José de San Martín, Universidad de Buenos Aires, Córdoba 2351 1er subsuelo, CP1120AAF, Ciudad de Buenos Aires, Argentina.

Background: Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this study, we evaluated the in vitro photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene.

Methods: The cell line employed was the LM3 mammary adenocarcinoma, and the PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. Read More

J Clin Lab Anal 2021 May 12:e23816. Epub 2021 May 12.

Division of in vitro Diagnostics, Shenzhen Mindray Bio-Medical Electronics Corporation, Shenzhen, China.

Background: Serum biomarkers have been widely adopted in clinical practice for assisting lung cancer diagnoses, therapeutic monitoring, and prognostication. The function of a well-performing tumor biomarker depends on a reliable reference interval (RI) with consideration of the study subjects' age, gender, and geographical location. This study aimed to establish a RI for each of 6 lung cancer biomarkers for use in the whole country of China on Mindray platform. Read More

Endocrine 2021 May 12. Epub 2021 May 12.

Division of Endocrinology, Diabetes and Metabolism, The Chaim Sheba Medical Center, Tel-HaShomer, Ramat-Gan, Israel.

Purpose: Lung neoplasms often co-occur with pituitary adenoma (PA). However, whether co-diagnosis of lung neuroendocrine tumors (LNETs) and PA constitute a unique entity and the impact of such co-diagnosis on patients' outcome is yet to be defined. The study objective was to compare patients' clinical characteristics with LNET to patients co-diagnosed with PA. Read More

Kyobu Geka 2021 May;74(5):401-403

Department of Thoracic and Cardiovascular Surgery, University of Saga, Saga, Japan.

A 74-year-old man had previously been treated for primary malignant melanoma of the bladder. Three years after surgery, 8 mm round nodule in the right lower lobe was found on chest computed tomography. The nodule increased to 11 mm after three months, and resected with a diagnosis of metastatic malignant melanoma. Read More

Kyobu Geka 2021 May;74(5):343-346

Department of General Thoracic Surgery, Chugoku Central Hospital, Fukuyama, Japan.

A 76-year-old man visited to the hospital with a complaint of cough. The chest computed tomography scan revealed a 20 mm part-solid nodule in the right lower lobe, which was suspected to be an early-stage lung cancer. Since the tumor was located in S8a, and was adjacent to S6b and S9a, thoracoscopic right S 6b+S 8a+S 9a combined subsegmentectomy was performed. Read More

Kyobu Geka 2021 May;74(5):331-335

Department of Thoracic Surgery, Tokyo Women's Medical University, Tokyo, Japan.

Lung nodules during postoperative follow-up of lung cancer are generally suspected to be its recurrence, but some cases are diagnosed as non-malignant disease. From January 2001 to November 2018, we experienced 5( 4.5%) new non-malignant lesions in 112 lung cancer patients who underwent a lung resection. Read More

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Department of Ophthalmology, University of Science Malaysia-Kesihatan Campus, Kubang Kerian, Kelantan, Malaysia.

We describe an uncommon cause of paraneoplastic optic neuropathy in adenocarcinoma of the lung. A 45-year-old healthy woman presented with seizure and encephalitis, followed by an acute visual loss in both eyes for 1 week. Her visual acuity was no perception of light in the right eye and hand movement in the left eye. Read More

J Cancer 2021 31;12(11):3136-3144. Epub 2021 Mar 31.

Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 52, 20122, Milan, Italy.

Smoking is one of the leading causes of death worldwide, and it is strongly associated with several human cancers. However, the differential effects of cigarette smoke on the development and progression of different types of cancer remain unclear, and related data are limited. In this longitudinal cohort study conducted among 75,324 women aged 41-76 years, we aimed to evaluate the effect of exposure to tobacco smoke on cancer development. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):566-568

Dept. of Surgery, Yokohama City University.

The patient was a 59‒year‒old woman. In 2005, she underwent low anterior resection plus D2 dissection for rectal cancer (pT4aN2aM0, pStage Ⅲb). In 2007, she underwent hepatic S8 subsegment resection for liver metastasis. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):493-498

Division of Medical Oncology, Dept. of Internal Medicine, Teikyo University School of Medicine.

As a treatment strategy for various carcinoma, immune checkpoint inhibitors(ICIs)can prolong overall survival with ICI monotherapy, ICIs combination therapy, or chemotherapy and ICI combination therapy. It has been validated in clinical trials and is recognized as a key drug in the treatment of cancer. In two large phase Ⅲ trials(IMpower133 and CASPIAN), the strategy of anti PD‒L1 antibody, such as atezolizumab and durvalumab, with chemotherapy was prolonged overall survival compared with the chemotherapy alone in extensive stage small cell lung cancer. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):486-492

Dept. of Thoracic Oncology, Kobe Minimally Invasive Cancer Center.

Small cell lung cancer(SCLC)frequently develops both brain metastases and bone metastases. Considering the negative effects on quality of life(QOL), it is essential to manage properly these metastases. In patients with limited‒disease(LD) SCLC who have a good response to chemoradiotherapy, prophylactic cranial irradiation(PCI)is given to decrease brain metastases. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):476-485

Dept. of Thoracic Oncology, National Cancer Center Hospital East.

Small cell lung cancer(SCLC)is one of the histological types of lung cancer showing the worst prognosis, and is often diagnosed as an inoperable advanced stage disease. Recently, several comprehensive genomic analyses for SCLC have shown that inactivating mutations of tumor suppressor genes such as TP53 and RB1 and MYC family gene amplifications are involved in the development and progression of SCLC. However, actionable gene alterations for targeted therapies have not yet been identified, and there has been no significant advance in the development of targeted therapies for SCLC. Read More

Gan To Kagaku Ryoho 2021 Apr;48(4):472-475

Dept. of Diagnostic Pathology, National Cancer Center Hospital.

The name of small cell carcinoma is becoming unified with neuroendocrine carcinoma in many other cancers except lung cancer, and following this trend, small cell carcinoma of the lung categorized into a subtype under neuroendocrine carcinoma in the 2015 WHO classification. However, small cell carcinoma has been retained and remain as a distinct entity. In this article, I introduced the history and current concept of small cell lung cancer classification, as well as the molecular biological classification of small cell lung cancer based on 4 definitive molecules, ASCL1, NEUROD1, YAP1, and POU2F3, proposed in 2019. Read More

Kyobu Geka 2021 Feb;74(2):160-163

Department of General Thoracic Surgery, National Obihiro Hospital, Obihiro, Japan.

A 60-year-old woman with a lung tumor was admitted to our hospital for surgical treatment. Chest computed tomography (CT) showed a 23×21×20 mm nodule in the right lower lobe. Although the lung nodule was thought to be benign due to CT image findings, its size was apparently larger than that of CT image at four years ago. Read More

Kyobu Geka 2021 Feb;74(2):156-159

Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Japan.

A 69-year-old woman was referred to our hospital because of an abnormal shadow on a chest roentgenogram at a medical check-up. Chest computed tomography showed a 2.5 cm-diameter tumor in the right pulmonary lower lobe. Read More

Kyobu Geka 2021 Feb;74(2):112-115

Department of Thoracic Surgery, Kansai Medical University, Hirakata, Japan.

We herein report a rare case of an antero-basal pulmonary artery that was noticed during left upper lung lobectomy. A 61-year-old man underwent surgery and radiation for a brain tumor, which was diagnosed as a solitary metastasis of the primary lung cancer in the upper lobe of the left lung. He underwent left upper lobectomy for the lung cancer. Read More

Kyobu Geka 2021 Feb;74(2):87-91

Department of Thoracic Surgery, Iwate Prefectural Isawa Hospital, Oshu, Japan.

To evaluate the clinical features of patients who developed resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) administered for postoperative recurrence of lung cancer, we assessed eight patients who underwent surgical biopsy or sampling for the detection of T790M mutation under general anesthesia from 2017 to 2019 in our hospital. All 8 patients had undergone lobectomy with nodal dissection for lung cancer of pathological stageⅠB/Ⅲ/Ⅳa (4/3/1 patients). The median disease-free survival was 29 months (range:11~110 months). Read More

J Med Case Rep 2021 May 12;15(1):265. Epub 2021 May 12.

Department of Cardiothoracic Surgery, Affiliated Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing, 210000, Jiangsu, China.

Background: Primary lung cancer is one of the most frequently diagnosed cancers. The common metastatic sites are the liver, bones, brain, adrenal glands and central nervous system. However, gastrointestinal metastases, particularly esophageal metastases, from lung cancer are rare. Read More

Intern Med J 2021 May 11. Epub 2021 May 11.

Parkville Integrated Palliative Care Service, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Parkville, Victoria 3050, AustraliaSir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, 3010, Australia.

Background: Opioids have an important role in symptom management for people with advanced cancer. Clinical guidelines recommend patient education to ensure the safe use of opioids, however, no Australian studies have explored current education and safeguarding practices when opioids are initiated to advanced cancer patients.

Aims: To investigate risk assessment, safeguarding and education practices when opioids are first prescribed to advanced lung cancer patients METHODS: A retrospective medical record audit of outpatients with advanced non-small cell lung cancer seen at a tertiary Australian hospital between 1/1/2015 - 31/12/2019 and prescribed strong opioids for cancer-related symptoms. Read More

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Department of Obstetrics and Gynecology, Orlando Health Corp, Orlando, Florida, USA

The approach to metastatic lung cancer has long been focused on palliation therapy and comfort care. Recently, significant subsets of patients who suffer from a limited form of the disease have shown curative outcomes. The oligometastatic disease theory was first introduced in 1995, and since has been applied to many solid tumours. Read More

World J Clin Cases 2021 Apr;9(12):2811-2815

Division of Thoracic Surgery, Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan.

Background: Primary carcinoma ex pleomorphic adenoma arising from the tracheobronchial system is rarely reported.

Case Summary: We present a patient with primary carcinoma ex pleomorphic adenoma of the bronchus and review the associated literature for further comparison, including age, clinical manifestations, and diagnostic process. This patient had no history of neoplasms of the salivary gland. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):259-264

Department of Respiratory and Critical Care Medicine,Daping Hospital,Army Medical University of the People's Liberation Army,Chongqing 400042,China.

Targeted therapy is an important therapeutic method for advanced non-small cell lung cancer with driver gene alteration.However,resistance to targeted therapy will inevitably happen in clinical practice,which has become a major issue demanding prompt solution.Studies have demonstrated that bypass resistance mediated by the activation of hepatocyte growth factor(HGF)/mesenchymal-epithelial transition factor(MET)signaling pathway is a common cause of resistance to targeted therapy. Read More

Ann Palliat Med 2021 Apr;10(4):4409-4417

Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Background: The aim of the present study was to establish a new prediction model for radiation pneumonitis (RP) in locally advanced non-small cell lung cancer (LA-NSCLC) patients before and after radiotherapy.

Methods: The study involved 153 patients. Age, arterial partial oxygen pressure (PO2), forced vital capacity, pulmonary emphysema (PE), subclinical interstitial lung disease (sILD), and dosimetric parameters, such as mean lung dose and percentage of lung volume, and a dose >5/20 Gy (V5/V20), were considered candidate RP predictors. Read More

Ann Palliat Med 2021 Apr;10(4):4999-5009

Department of Cardiothoracic Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo, China.

Lung cancer is a malignancy with the highest morbidity and mortality in the world. Radiotherapy, chemotherapy, targeted therapy, and immunotherapy have been widely used to treat metastatic non-small cell lung cancer (NSCLC). Stereotactic body radiotherapy (SBRT), also known as stereotactic ablation radiotherapy (SABR), can precisely deliver a high dose of radiation to a target in a limited area. Read More

Ann Palliat Med 2021 Apr;10(4):4987-4993

Department of Thoracic Surgery, Fuzhou Pulmonary Hospital of Fujian, Fuzhou, China.

The patient was a middle-aged male smoker who had space-occupying lesions in the right upper lung, Positron emission tomography-computed tomography (PET-CT) suggested right upper lung cancer with multiple mediastinal lymph node metastases. Endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-GS-TBLB) performed in the bronchus of the right apical segment confirmed the lesion as squamous cell carcinoma. Neoadjuvant therapy was planned. Read More

Ann Palliat Med 2021 Apr;10(4):4982-4986

Department of Thoracic Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuzhou, China.

Immune checkpoint inhibitors (ICIs) have become an important milestone in the treatment of non-small cell lung cancer (NSCLC). High expression of protein ligand 1 (PD-L1) and tumor mutation burden (TMB) can help to select the dominant population for immunotherapy, but the expression of PD-L1 does not seem to be unchanged. A 61-year-old man with adenocarcinoma of the lung experienced postoperative recurrence. Read More