273,274 results match your criteria Neoplasms Lung


The repair using a fibular graft of cervical vertebral collapse due to renal cell carcinoma: Late results with a case report.

J Craniovertebr Junction Spine 2018 Oct-Dec;9(4):267-270

Department of Pathology, Research and Training Hospital, Recep Tayyip Erdogan University, Rize, Turkey.

The most common cause of spinal tumors is metastases, but the cervical vertebra is the least common region of spinal metastasis, and relatively, little is published about surgery in metastasis to the cervical vertebra. While spinal metastasis is most often caused by neoplasms originating from the lung, breast, and prostate, renal cell carcinoma (RCC) metastasis is very rare. A 47-year-old patient introduced here presented with severe pain spontaneously on his neck and in his arm. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_32_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364372PMC
February 2019

Korean First Prospective Phase II Study, Feasibility of Prone Position in Postoperative Whole Breast Radiotherapy: A Dosimetric Comparison.

Cancer Res Treat 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: This first Korean prospective study is to evaluate the feasibility of prone breast radiotherapy after breast conserving surgery for left breast cancer patients who have relatively small breast size and we present dosimetric comparison between prone and supine positions.

Materials And Methods: Fifty patients underwent two computed tomography (CT) simulations in supine and prone positions. Whole breast, ipsilateral lung, heart, and left-anterior-descending coronary artery were contoured on each simulation CT images. Read More

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http://dx.doi.org/10.4143/crt.2018.423DOI Listing
February 2019

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program.

Cancer Res Treat 2019 Feb 19. Epub 2019 Feb 19.

National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement national cancer screening program in Korea.

Methods: Multidisciplinary expert committee was comprised to develop a standardized protocol forKorean Lung Cancer Screening Project (K-LUCAS). Read More

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http://dx.doi.org/10.4143/crt.2018.464DOI Listing
February 2019

Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.

Pathol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non-gestational in origin. However, primary non-gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non-gestational uterine choriocarcinoma. Read More

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http://dx.doi.org/10.1111/pin.12763DOI Listing
February 2019

PATHOLOGICAL FRACTURES DUE TO BONE METASTASES FROM LUNG CANCER: RISK FACTORS AND SURVIVAL.

Acta Ortop Bras 2018 ;26(6):388-393

Escola de Saúde do Exército, Rio de Janeiro, RJ, Brazil.

Introduction: Pathological fractures are frequent skeletal-related events among lung cancer patients, which result in high morbidity and decreased overall survival and make operative treatment decisions challenging.

Objectives: To identify risk factors associated with the occurrence of pathological fractures in patients with lung cancer and to determine survival.

Methods: We conducted a retrospective cohort study with 407 lung carcinoma patients diagnosed between 2006 and 2015. Read More

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http://dx.doi.org/10.1590/1413-785220182606201669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362688PMC
January 2018

Management of fetal tumors.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 14. Epub 2019 Jan 14.

Fetal Medicine Unit, Department of Obstetrics and Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada. Electronic address:

In this review article, we discuss the most common fetal tumors, their prenatal management, and outcomes. Overall, the most important outcome predictors are tumor histology, size, vascularity, and location. Very large lesions, lesions causing cardiac failure, and hydrops and lesions obstructing the fetal airway have the poorest outcome, as they may cause fetal death or complications at the time of delivery. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.01.006DOI Listing
January 2019
2 Reads

Managing Pharmacotherapy in People Living With HIV and Concomitant Malignancy.

Ann Pharmacother 2019 Feb 15:1060028019833038. Epub 2019 Feb 15.

4 Massachusetts College of Pharmacy and Health Sciences University, School of Pharmacy, Worcester, MA, USA.

Objective: To describe data with selected malignancies in people living with HIV (PLWH) and HIV in individuals affected by both conditions and to summarize drug-drug interactions (DDIs) with clinical recommendations for point-of-care review of combination therapies.

Data Sources: Literature searches were performed (2005 to December 2018) in MEDLINE and EMBASE to identify studies of malignancies in PLWH in the modern era.

Study Selection And Data Extraction: Article bibliographies and drug interaction databases were reviewed. Read More

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http://dx.doi.org/10.1177/1060028019833038DOI Listing
February 2019
2 Reads

High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma.

Klin Onkol 2019 ;32(1):52-57

Background: Interstitial low dose rate brachyther-apy is established organ spar-ing treatment of T1- T2 penile carcinoma. Experience with high-dose rate brachyther-apy is limited in this indication.

Materials And Methods: Twenty-six patients with early penile carcinoma were treated by high-dose rate brachyther-apy at dose 18 × 3 Gy per fraction twice daily between 2002- 2018 at the Department of Oncology and Radiother-apy, University Hospital in Hradec Kralove. Read More

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http://dx.doi.org/10.14735/amko201952DOI Listing
January 2019

Imaging features of SMARCA4-deficient thoracic sarcomas: a multi-centric study of 21 patients.

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology, Institut Bergonié, Comprehensive Cancer Center, 229, cours de l'Argonne, F-33000, Bordeaux, France.

Objectives: SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently identified aggressive subtype of sarcoma. The aim of this study was to characterize the CT imaging features of SMARCA4-DTS.

Methods: From June 2011 to May 2017, 21 adult patients with histologically proven SMARCA4-DTS were identified in the radiological database of 2 French sarcoma reference centers with at least one chest CT scan available. Read More

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http://dx.doi.org/10.1007/s00330-019-06017-xDOI Listing
February 2019
2 Reads

Thymic Carcinoma Associated with Cerebellar Degeneration.

Eur J Case Rep Intern Med 2018 21;5(3):000780. Epub 2018 Mar 21.

Department of Internal Medicine, Villarrobledo General Hospital, Villarrobledo, Albacete, Spain.

We present the case of a 57-year-old man with ataxia and clinical and radiological features of cerebellar degeneration. Computed tomography showed a mediastinal mass and the patient was diagnosed with thymic carcinoma. Paraneoplastic cerebellar degeneration is aninfrequent disorder and its association with thymic carcinoma very rare. Read More

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http://dx.doi.org/10.12890/2018_000780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346953PMC
March 2018
1 Read

DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.

J Exp Clin Cancer Res 2019 Feb 12;38(1):72. Epub 2019 Feb 12.

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Background: Damage-regulated autophagy modulator 2(DRAM2) is associated with autophagy processes. However, the role of DRAM2 in the progression of human neoplasms is still unknown. Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-
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http://dx.doi.org/10.1186/s13046-019-1068-4DOI Listing
February 2019
1 Read

Spontaneous pneumothorax in the elderly: a sign of a malignancy?

Asian Cardiovasc Thorac Ann 2019 Feb 12:218492319831840. Epub 2019 Feb 12.

2 Thoracic Surgery Clinic, University of Health Sciences, Sureyyapasa Training and Research Hospital, Istanbul, Turkey.

Background: Spontaneous pneumothorax usually occurs as a result of rupture of a subpleural bleb or emphysematous bulla. Spontaneous pneumothorax, which is more common in younger age groups, might be the first sign of pulmonary malignancy, especially when it manifests in older patients.

Methods: Data of all patients who were treated for spontaneous pneumothorax in our clinic between June 2013 and June 2017 were examined retrospectively. Read More

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http://dx.doi.org/10.1177/0218492319831840DOI Listing
February 2019
1 Read

Uterine Inflammatory Myofibroblastic Tumor Showing an Atypical ALK Signal Pattern by FISH and DES-ALK Fusion by RNA Sequencing: A Case Report.

Int J Gynecol Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio (S.Z., F.W.A.-K., C.A., M.L.C.P.-N.) University of Arizona College of Medicine Phoenix and Creighton University Phoenix College of Medicine (D.M.C.).

Inflammatory myofibroblastic tumors (IMTs) are spindle cell neoplasms of intermediate (borderline) biologic potential with tendency for local recurrence but low risk of metastasis. They affect children more than adults. The most common sites of involvement are the lung, soft tissue, peritoneum, bladder, and less commonly the gynecologic tract. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000588DOI Listing
February 2019
1 Read

Clinicopathological Features and Treatment Outcomes of Solid Pseudopapillary Neoplasms of the Pancreas: A 10-Year Case Series from a Single Center.

J Laparoendosc Adv Surg Tech A 2019 Feb 11. Epub 2019 Feb 11.

1 Department of General Surgery, Qilu Hospital, Shandong University, Jinan, China.

Background: Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare pancreatic tumors. This study summarizes the clinicopathological characteristics and treatment outcomes of SPN patients through a 10-year single-center case series.

Materials And Methods: Medical records of patients diagnosed with SPNs and who underwent surgery between August 2007 and July 2017 at Qilu Hospital, Shandong University, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1089/lap.2018.0704DOI Listing
February 2019
2 Reads

Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change.

An Bras Dermatol 2019 Jan-Feb;94(1):76-78

Department of Pathology, Laboratório Bacchi, Botucatu (SP), Brazil.

Cutaneous metastases are uncommon in daily practice, although very important, since they may be the first manifestation of an undiscovered primary neoplasm or the first indication of recurrence. Cutaneous metastases from the breast are the most frequent in women and cutaneous metastases from the lung are the most frequent in men. Thyroid carcinoma, despite representing the most frequent endocrine neoplasm, is considered a rare neoplasm, corresponding to 1% of malignant neoplasms diagnosed. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20198299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360978PMC
March 2018
6 Reads

Fit for Cancer Treatment: a prospective feasibility study of primary care initiated prehabilitation for patients with suspected cancer.

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348330PMC
December 2018
2 Reads

Evaluation of intracavitary carboplatin chemotherapy for treatment of pleural carcinomatosis in cats: a retrospective study of eight cases.

J Feline Med Surg 2019 Feb 5:1098612X19826401. Epub 2019 Feb 5.

1 ONCOVET, Veterinary Clinic of Referrals, Villeneuve d'Ascq, France.

Objectives: The aim of this study was to evaluate the benefit of intracavitary carboplatin chemotherapy in cats with malignant pleural effusion of epithelial origin.

Methods: The medical records of cats with a cytological diagnosis of neoplastic pleural effusion of epithelial origin were reviewed at three referral institutions between January 2013 and June 2018. Only cats treated with intracavitary carboplatin chemotherapy were enrolled. Read More

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http://dx.doi.org/10.1177/1098612X19826401DOI Listing
February 2019
1 Read

Pediatric Chest MRI: A Review.

Indian J Pediatr 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 110029, India.

Chest radiographs and CT scans have been the cornerstone of pulmonary imaging given their advantages of being rapid and easily available techniques. However, a significant concern with their use in the pediatric population is the associated ionisation radiation. The use of magnetic resonance imaging (MRI) in pulmonary imaging has lagged behind its adoption in other organ systems. Read More

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http://dx.doi.org/10.1007/s12098-018-02852-wDOI Listing
February 2019
4 Reads

CircRNAs and lung cancer: Biomarkers and master regulators.

Life Sci 2019 Mar 31;220:177-185. Epub 2019 Jan 31.

Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

CircRNAs are a class of competitive, endogenous, non-coding RNAs with closed-loop structures. High-throughput sequencing indicates that circRNAs are ubiquitously expressed in many eukaryotes. Biological functions of circRNAs include interaction with proteins and regulation of gene transcription, translation, and miRNA sponge activity. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.055DOI Listing

Tolerability and activity of ublituximab, umbralisib, and ibrutinib in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: a phase 1 dose escalation and expansion trial.

Lancet Haematol 2019 Feb;6(2):e100-e109

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Therapeutic approaches for B-cell malignancies continue to evolve, especially with regard to combination approaches. We assessed the safety and efficacy of the triplet ublituximab, umbralisib, and ibrutinib in patients with advanced B-cell malignancies.

Methods: We did an open-label, phase 1 study with dose-escalation and dose-expansion phases, at five centres in the USA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523026183021
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http://dx.doi.org/10.1016/S2352-3026(18)30216-3DOI Listing
February 2019
3 Reads

Bronchial angiolipoma successfully treated by sleeve resection of the right bronchus intermedius: a case report.

BMC Surg 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Thoracic Surgery, Iwate Prefectural Central Hospital, Ueda 1-4-1, Morioka, 020-0066, Japan.

Background: Angiolipoma is a rare, benign tumor that primarily develops in the limbs and trunk. The occurrence of angiolipoma in the lungs is extremely rare; to date, only two cases of primary bronchial angiolipoma have been reported. Here, we report a case of angiolipoma of the right bronchus intermedius that was successfully treated with sleeve resection and reconstructive surgery. Read More

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http://dx.doi.org/10.1186/s12893-019-0481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357366PMC
January 2019

[Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Feb;42(2):101-105

Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To investigate the clinical significance of recombinant virus-specific detection for detecting viable circulating tumor cell (CTC) in lung cancer patients. From June 2017 to August 2018, 63 lung cancer patients diagnosed by imaging and pathology at the Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital were recruited for this study, including 38 cases of adenocarcinoma, 13 squamous cell carcinoma, and 12 small cell carcinoma. The patients consisted of 36 males and 27 females, with an average age of (65±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.02.005DOI Listing
February 2019
1 Read

Low dose of apatinib in treating chemotherapy and EGFR-TKI refractory non-small cell lung cancer: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14328

Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Rationale: Lung cancer is the leading cause of cancer-associated deaths all over the world. Although the prognosis of lung cancer has improved over the past decade due to progression in surgical techniques and systematic treatments, the patients with advanced disease still suffer poor survival. There are no standard treatment strategies for patients who have failed to respond to at least 2 lines of chemotherapy in non-small cell lung cancer (NSCLC). Read More

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http://dx.doi.org/10.1097/MD.0000000000014328DOI Listing
February 2019
1 Read

Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature.

Medicine (Baltimore) 2019 Feb;98(5):e14315

Department of Pathology, the First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang.

Rationale: Sclerosing pneumocytoma accompanied with other type of tumor in one patient is very rare. Here, we report a case of a sclerosing pneumocytoma mixed with a typical carcinoid tumor in a same neoplasm.

Patient Concerns: A 55-year-old woman incidentally detected a space-occupying lesion of right lung in routine health examination. Read More

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http://dx.doi.org/10.1097/MD.0000000000014315DOI Listing
February 2019

Solitary renal metastasis from squamous cell carcinoma of the lung: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14310

Department of Lung Cancer Center, Cancer Center of West China Hospital.

Rationale: Non-small cell cancer with isolated unilateral renal metastasis is rare, and the role of radical nephrectomy has not been determined. In the present study, a case of a patient with solitary kidney metastasis from squamous cell lung cancer who underwent radical nephrectomy is reported.

Patient Concerns: A 74-year-old patient diagnosed with pulmonary squamous cell lung cancer who had undergone radical pulmonary lobectomy and mediastinal lymph node dissection revealed a solitary mass in the right kidney during the follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000014310DOI Listing
February 2019
1 Read
5.723 Impact Factor

Extrauterine epithelioid trophoblastic tumors presenting as lung mass: A case report and literature review.

Medicine (Baltimore) 2019 Feb;98(5):e14010

Department of Obstetrics and Gynecology.

Rationale: Extrauterine epithelioid trophoblastic tumors (ETT) is a rare variant of gestational trophoblastic neoplasms. Here we aim to learn more clinical and pathological characteristics of ETT patient with an isolated pulmonary mass without uterine lesions, through a rare case of extra-uterine ETT and 7 cases published in English periodicals literature.

Patient Concerns: A 31-year-old Chinese woman, presented with low-level elevation of serum human chorionic gonadotropin (HCG) for more than 2 years without abnormal symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000014010DOI Listing
February 2019
1 Read

Clinical characteristics and prognostic analysis of multiple primary malignant neoplasms in patients with lung cancer.

Cancer Gene Ther 2019 Jan 31. Epub 2019 Jan 31.

Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, 450008, Zhengzhou, China.

Retrospective analysis of data from 14,528 lung cancer patients with multiple primary malignant neoplasm (MPMN) revealed that 2.5% (364/14,528) were MPMN cases and 96.2% (350/364) were diagnosed with two primary malignancies, 3. Read More

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http://www.nature.com/articles/s41417-019-0084-z
Publisher Site
http://dx.doi.org/10.1038/s41417-019-0084-zDOI Listing
January 2019
3 Reads

Surprising Bone and Soft Tissue Lesions of the Chest: Pictorial Review.

Semin Musculoskelet Radiol 2019 Feb 30;23(1):85-96. Epub 2019 Jan 30.

Department of Radiology, Ghent University, UZ-Gent, Gent, Belgium.

Although plain radiographs of the chest are usually requested to evaluate the heart, lung, and mediastinum, many bone and soft tissue, metabolic, and congenital lesions can be visible presenting as surprising lesions. Thorough analysis of the lesion characteristics on the chest radiograph, eventually in conjunction with more advanced imaging techniques and in combination with the clinical findings, will lead to the correct diagnosis. Read More

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http://dx.doi.org/10.1055/s-0038-1675549DOI Listing
February 2019
1 Read

Histomorphological and Immunohistochemical Analysis of Pleural Neoplasms.

Iran J Pathol 2018 17;13(2):196-204. Epub 2018 Jul 17.

Registrar Pathology, Apollo Hospitals, Bangalore, Bangalore, India.

Background & Objective: Primary pleural neoplasms are rare entities compared with the pleural involvement by metastatic carcinoma.The current study aimed at investigating the complete spectrum of pleural neoplasms and differentiating between them with the aid of immunohistochemistry (IHC).

Methods: Consecutive pleural biopsy specimens positive for a neoplasm, both primary and metastatic, were included in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339503PMC
July 2018
1 Read

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
8 Reads

[Clinicopathological characteristics of fumarate hydratase-deficient renal cell carcinoma].

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):120-126

Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.

To investigate the clinicopathologic characteristics, molecular and genetic features, differential diagnoses and prognosis of fumarate hydratase-deficient renal cell carcinoma (FH-RCC). The immunohistochemical (IHC) expression of FH in 391 renal neoplasms in tissue chips collected from the Affiliated Hospital of Qingdao University and 971 Hospital of PLA Navy from January 2011 to December 2017 was evaluated. The clinicopathologic data of eight FH negative cases were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.02.009DOI Listing
February 2019
6 Reads

[Cortical blindness as initial manifestation of nonbacterial thrombotic endocarditis].

Medicina (B Aires) 2019 ;79(1):61-63

Instituto de Cardiología y Cirugía Cardiovascular (ICyCC), Hospital Universitario Fundación Favaloro, Buenos Aires, Argentina.

Nonbacterial thrombotic endocarditis, formerly known as marantic endocarditis, it is an infrequent entity in which sterile, fibrin vegetations develop on heart valve leaflets. It is often diagnosed at the time of autopsy or in latestage malignancies. The most common malignancies associated with nonbacterial thrombotic endocarditis are lung, pancreatic, gastric cancer and adenocarcinomas of an unknown primary site. Read More

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January 2019
1 Read

Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy.

Radiat Oncol 2019 Jan 28;14(1):19. Epub 2019 Jan 28.

Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Idiopathic pulmonary fibrosis (IPF) is associated with fatal complications after radiotherapy (RT) for lung cancer patients; however, the role of proton therapy to reduce the incidence of life-threatening complications is unclear. Herein, we present the preliminary results of early-stage lung cancer patients having IPF and treated with RT, with a focus on the comparison between X-ray and proton therapy.

Methods: From January 2010 to October 2017, we retrospectively reviewed the medical records of 264 patients with stage I-II non-small cell lung cancer (NSCLC) treated with definitive RT alone. Read More

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http://dx.doi.org/10.1186/s13014-019-1221-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348683PMC
January 2019
2 Reads

Overall survival according to immunotherapy and radiation treatment for metastatic non-small-cell lung cancer: a National Cancer Database analysis.

Radiat Oncol 2019 Jan 28;14(1):18. Epub 2019 Jan 28.

Department of Radiation and Cellular Oncology, The University of Chicago Medicine, 5758 S. Maryland Avenue, MC 9006, Chicago, IL, 60637, USA.

Background: Preclinical studies suggest enhanced anti-tumor activity with combined radioimmunotherapy. We hypothesized that radiation (RT) + immunotherapy would associate with improved overall survival (OS) compared to immunotherapy or chemotherapy alone for patients with newly diagnosed metastatic non-small-cell lung cancer (NSCLC).

Methods: The National Cancer Database was queried for patients with stage IV NSCLC receiving chemotherapy or immunotherapy from 2013 to 2014. Read More

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http://dx.doi.org/10.1186/s13014-019-1222-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348608PMC
January 2019
1 Read

Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma.

World J Surg Oncol 2019 Jan 28;17(1):23. Epub 2019 Jan 28.

Department of Orthopaedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.

Background: Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma. Read More

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http://dx.doi.org/10.1186/s12957-019-1566-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350278PMC
January 2019

A global perspective on coal-fired power plants and burden of lung cancer.

Environ Health 2019 01 28;18(1). Epub 2019 Jan 28.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Building 1, Room 1401, Boston, MA, 02115, USA.

Background: Exposure to ambient particulate matter generated from coal-fired power plants induces long-term health consequences. However, epidemiologic studies have not yet focused on attributing these health burdens specifically to energy consumption, impeding targeted intervention policies. We hypothesize that the generating capacity of coal-fired power plants may be associated with lung cancer incidence at the national level. Read More

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https://ehjournal.biomedcentral.com/articles/10.1186/s12940-
Publisher Site
http://dx.doi.org/10.1186/s12940-019-0448-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350330PMC
January 2019
4 Reads

Superior vena cava syndrome early after pacemaker implantation in a patient with lung carcinoma: A case report.

Rev Port Cardiol 2019 Jan 23;38(1):65.e1-65.e3. Epub 2019 Jan 23.

Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Superior vena cava (SVC) syndrome is typically dramatic. Although the diagnosis is usually easy, elucidation of the etiology is difficult. We present a patient who developed SVC syndrome early after transvenous pacemaker implantation and who was subsequently diagnosed with lung carcinoma. Read More

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http://dx.doi.org/10.1016/j.repc.2018.05.016DOI Listing
January 2019
3 Reads

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019
5 Reads
10.742 Impact Factor

Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy.

Radiat Oncol 2019 Jan 25;14(1):16. Epub 2019 Jan 25.

Department of Radiation Oncology, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Fudan University, Shanghai, China.

Background: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

Methods: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1216-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347845PMC
January 2019
2 Reads

Bullous Pemphigoid Associated With a New Combination Checkpoint Inhibitor Immunotherapy

J Drugs Dermatol 2019 Jan;18(1):103-104

Novel immunotherapies including antibodies to programmed death ligand 1 (PD-1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) have become common therapies for neoplasms including metastatic melanoma and non-small cell lung cancer (NSCLC). Dermatologic toxicity is the most common adverse event associated with these immunotherapies. We report a case of bullous pemphogoid (BP) in a patient receiving combination durvalumab and tremelimumab, two newer immunotherapy checkpoint inhibitors under investigation in phase III trials. Read More

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January 2019
4 Reads

A case report of primary osteosarcoma originating from kidney.

Medicine (Baltimore) 2019 Jan;98(4):e14234

Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Rationale: Primary osteosarcoma of the kidney is a very rare subtype of renal neoplasms. There are only 27 cases reported in the literature since 1936. In addition, it has a high risk of metastasis and very low survival rate. Read More

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http://dx.doi.org/10.1097/MD.0000000000014234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358323PMC
January 2019
2 Reads

Free bipaddled anterolateral thigh flap for simultaneous reconstruction of large larynx and prelaryngeal skin defects after resection of the local recurrent laryngeal cancer invading the cricoid cartilage and prelaryngeal skin: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14199

Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: After total or near-total laryngectomy and resection of prelaryngeal skin, laryngeal defects and prelaryngeal skin defects often remain a great challenge for head and neck surgeons when considering simultaneous reconstruction of. In this case report, a free bipaddled anterolateral thigh (ALT) was used for such defects reconstruction.

Patient Concerns: For this 50-year-old male patient whose recurrent tumor invaded the cricoid cartilage and the prelaryngeal skin, supracricoid partial laryngectomy with a cricohyoidepiglottopexy would no longer be an option. Read More

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http://dx.doi.org/10.1097/MD.0000000000014199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358393PMC
January 2019
1 Read
5.723 Impact Factor

Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14182

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, P. R. China.

Rationale: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. Read More

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http://dx.doi.org/10.1097/MD.0000000000014182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358397PMC
January 2019
1 Read

[The pathological characteristics and outcomes of 40 surgically treated stage M1b non-small cell lung cancer patients].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):63-67

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Clinical evidences of surgically treated stage M1b non-small cell lung cancer (NSCLC) patients were limited. This study aimed to summarize the clinical data of these patients to explore the prognostic factors of this population. From January 1999 to December 2012, the clinical data of 40 stage M1b NSCLC patients, including 24 males and 16 females, who underwent surgery were collected by Cancer Hospital, Chinese Academy of Medical Sciences. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.011DOI Listing
January 2019
1 Read

[The clinical and pathological features, biomarker characteristics and prognosis analysis of lung adenosquamous carcinoma].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):50-55

Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Adenosquamous carcinoma of lung is an uncommon subtype with more aggressive behavior and poor prognosis than adenocarcinoma and squamous cell carcinoma. This study was aimed to investigate the clinicopathological characteristics and prognostic factors of lung adenosquamous carcinoma. The pathological features and follow-up data of 133 patients were collected and the prognostic factors of these patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.009DOI Listing
January 2019
2 Reads

[Report of cancer epidemiology in China, 2015].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):19-28

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Data from local cancer registries were pooled to estimate cancer incidence and mortality in China, 2015. Data submitted from 501 cancer registries were checked & evaluated according to the criteria of data quality control, and 368 registries' data were qualified for the final analysis. Data were stratified by area (urban/rural), sex, age group and cancer sites, and combined with national population data to estimate cancer incidence and mortality in China, 2015. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.005DOI Listing
January 2019

[Treatment principle and surgical technique of pulmonary ground glass nodules].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):6-9

Department of thoracic surgery, Zhongshan hospital, Fudan university, Shanghai 200032, China.

Pulmonary ground glass nodule (GGN) is a term of radiological manifestation, which may be malignant or benign. GGN's imaging performance is diverse, and the management for pulmonary GGN remains controversial. Numerous clinical studies have clarified the safety of GGN follow-up and longer follow-up intervals, stricter surgical or biopsy indications are recommended. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.002DOI Listing
January 2019
1 Read

[Molecular Mechanism and Progression of Primary Resistance to EGFR-TKI
- Analysis of 2 Cases].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):52-56

Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.

Tyrosine kinase inhibitor (TKI) have been proved to be effective in the treatment of advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) sensitive mutation, which is superior to chemotherapy. However, there are still some patients with sensitive mutations have primary drug resistance. It may be related to the coexistence of susceptible and resistant mutations of EGFR gene, downstream mutations of EGFR pathway, MET amplification and BIM deletion polymorphism. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348160PMC
January 2019
3 Reads

[Research Advances of JAK/STAT Signaling Pathway in Lung Cancer].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):45-51

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is one of the downstream pathways of cytokine signaling transduction. It regulates cell development, differentiation, proliferation, apoptosis and so on. The pathway is not only involved in the regulation of normal physiological processes, but also significant in the development of tumors, especially in hematologic malignancies. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348154PMC
January 2019
2 Reads

[Progress on the Study of PD-L1 Detection Methods in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi 2019 Jan;22(1):40-44

Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310000, China.

PD-1/PD-L1 inhibitors play an important role in the first-line and second-line treatment of non-small cell lung cancer (NSCLC), indicating a new treatment strategy of NSCLC. Completed clinical trials have shown that effective detection of PD-L1 expression is the key to the use of immunosuppressive agents. However, the gold standard for PD-L1 detection has still lacked. Read More

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http://www.lungca.org/index.php?journal=01&page=article&
Publisher Site
http://dx.doi.org/10.3779/j.issn.1009-3419.2019.01.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348155PMC
January 2019
7 Reads