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Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

Expert Opin Biol Ther 2019 Apr 19. Epub 2019 Apr 19.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore , MD , USA.

Introduction: The systemic treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the identification of actionable mutations and the use of targeted agents. Unfortunately, many tumors will acquire resistance and >75% of NSCLC cases lack for an actionable gene aberration. In this setting, immunotherapy rises as effective therapeutic where immune checkpoint inhibitors have entered or are entering the market in many neoplasms, including NSCLC. Read More

J Appl Physiol (1985) 2019 Apr 18. Epub 2019 Apr 18.

Pulmonology Department-Muscle and Respiratory System Research Unit (URMAR), CEXS, IMIM-Hospital del Mar, UPF, CIBERES, Spain.

Respiratory muscle dysfunction is common in patients with chronic obstructive pulmonary disease (COPD). Chronic contractile activity induces endoplasmic reticulum (ER) stress and unfolded protein response UPR in animals (animals and humans). We hypothesized that the respiratory muscle dysfunction associated with COPD may upregulate ER stress and UPR expression in diaphragm of stable patients with different degrees of airway obstruction and normal body composition. Read More

Neuroendocrinology 2019 Apr 16. Epub 2019 Apr 16.

Background: Identification of circulating tumor markers for clinical management in bronchopulmonary (BP) neuroendocrine tumors/neoplasms (NET/NEN) is of considerable clinical interest. Chromogranin A (CgA), a "universal" NET biomarker, is considered controversial as a circulating biomarker of BPNEN.

Aim: Assess utility of CgA in the diagnosis and management of BPNEN in a multicentric study. Read More

J Cancer Prev 2019 Mar 30;24(1):48-53. Epub 2019 Mar 30.

Cancer Prevention Center, Yonsei Cancer Center, Seoul, Korea.

Background: The National Lung Screening Trial (NLST) and NELSON trial showed that low-dose chest computed tomography (LDCT) screening significantly reduced the mortality form lung cancer. Although cancer survivors are known to have high risk for second malignant neoplasm (SMN), the usefulness of LDCT screening for lung cancer in cancer survivors is not clear.

Methods: Between August 2016 and August 2017, 633 long-term colorectal cancer (CRC) survivors visited the survivorship clinic in Cancer Prevention Center, Yonsei Cancer Center, Seoul, Republic of Korea. Read More

BMC Cancer 2019 Apr 16;19(1):362. Epub 2019 Apr 16.

Department of Gastroenterology and Endocrinology, University Hospital Marburg, Baldinger Strasse, 35043, Marburg, Germany.

Background: Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.

Methods: We retrospectively analyzed 51 patients with GEP-NEN and bronchopulmonary NEN excluding small cell lung cancer. Read More

Minerva Endocrinol 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Unit.

Neuroendocrine neoplams (NENs) of unknowm primary origin (UPO-NENs) are advanced neoplasms constituting 11%-22% of all NENs that by definition their primary tissue of origin has not been identified with standard diagnostic work-up. Delineating the primary site of origin of UPO-NENs has important implications for selecting the appropriate treatment and overall prognosis. The small bowel, followed by the lung and pancreas are the most prevalent primary sites of origin of UPO-NENs that are uncovered during an extensive and prolonged diagnostic work-up; however, a number of UPO-NENs may still remain occult even after prolonged follow-up. Read More

Thorac Cardiovasc Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy.

Background:  Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease.The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes.

Methods:  Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Read More

Respir Med Case Rep 2019 28;27:100831. Epub 2019 Mar 28.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA.

Benign metastasizing leiomyoma (BML) is a rare benign smooth muscle neoplasm that originates in the uterus and metastasizes to distant sites-most commonly the lungs. BMLs are often found incidentally in patients with a history of uterine leiomyoma(s) and tend to be indolent. Occasionally they may be symptomatic and rarely follow an aggressive clinical course. Read More

Turk Patoloji Derg 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Erzurum Regional Training and Research Hospital, ERZURUM, TURKEY.

Bronchial carcinoid tumors are primary lung neoplasms thought to originate from neuroendocrine cells, i.e. Kulchitsky cells, in the bronchial mucosa, although the type of cellular origin has not been clearly understood. Read More

Niger J Clin Pract 2019 Apr;22(4):585-587

Department of Pulmonary Diseases, Health Sciences University Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey.

Warthin's tumors which can easily be subjected to misinterpretation are encountered commonly in clinical practice. Warthin's tumors which generally have the localization of parotid gland cauda and have a slow growing characteristic can rarely be seen aside from parotid gland; such as cervical lymph nodes and minor salivary glands. A 56-year-old patient's case that comprised atypical coexistence of Warthin tumor with PET/CT scan positive cervical lymph nodes during the diagnostic examination carried out for a pulmonary mass lesion is presented. Read More

Harm Reduct J 2019 Apr 11;16(1):27. Epub 2019 Apr 11.

Regulatory Affairs, Altria Client Services LLC, 601 East Jackson Street, Richmond, VA, 23219, USA.

Background: Assessments supporting smokeless tobacco (SLT) disease risk are generally decades old. Newer epidemiological data may more accurately represent the health risks associated with contemporary US-based SLT products, many of which contain lower levels of hazardous and potentially hazardous chemicals compared to previously available SLT products.

Methods: Data from two longitudinal datasets (National Longitudinal Mortality Study-NLMS, and the National Health Interview Survey-NHIS) were analyzed to determine potential associations between SLT use and/or cigarette smoking and all-cause and disease-specific mortality. Read More

J Prev Med Public Health 2019 Mar 18;52(2):140-144. Epub 2019 Feb 18.

Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

Objectives: Investigating the survival of patients with cancer is vitally necessary for controlling the disease and for assessing treatment methods. This study aimed to compare various statistical models of survival and to determine the survival rate and its related factors among patients suffering from lung cancer.

Methods: In this retrospective cohort, the cumulative survival rate, median survival time, and factors associated with the survival of lung cancer patients were estimated using Cox, Weibull, exponential, and Gompertz regression models. Read More

Epigenet Insights 2019 31;12:2516865719840284. Epub 2019 Mar 31.

Cancer Epigenetics Laboratory, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.

DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify the tissue of origin of a wide range of benign and malignant neoplasms. Using microarray-based profiling and supervised machine learning algorithms, we and other groups have recently unraveled DNA methylation signatures capable of aiding the histomolecular diagnosis of different tumor types. We have explored the methylomes of metastatic brain tumors from patients with lung cancer, breast cancer, and cutaneous melanoma and primary brain neoplasms to build epigenetic classifiers. Read More

JAMA 2019 04;321(14):1359-1360

Associate Editor.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

G Chrousos, Pediatrics, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece.

Circadian rhythms in central and peripheral level are operated by transcriptional/translational feedback loops involving a set of genes called 'clock genes' that are implicated in the development of several diseases including malignancies. Dysregulation of Clock system can affect cancer susceptibility by regulating DNA damage and repair mechanisms as well as apoptosis. A number of oncogenic pathways can be dysregulated via clock genes' epigenetic alterations including hypermethylation of clock genes' promoters or variants of clock genes. Read More

Turk Thorac J 2019 Jan 31;20(2):153-156. Epub 2019 Jan 31.

Department of Pulmonary Medicine, Pacific Medical College and Hospital, Udaipur, Rajasthan, India.

A partial or complete resolution of the neoplastic lesion, either spontaneously or in the presence of therapy that is considered inadequate to exert significant influence on the growth of the neoplastic lesion, is considered a spontaneous regression. This phenomenon is extremely rare in lung neoplasms. A close follow up with imaging along with bronchoscopy and a biopsy of the lesion is essential, as they may have potential for distant spread even during radiological regression. Read More

Cureus 2019 Jan 25;11(1):e3955. Epub 2019 Jan 25.

Pathology, Xavier University School of Medicine, Oranjestad, ABW.

Cigarette smoke is widely regarded as a carcinogenic agent; thus, the incidence of relative neoplasms correlates to cigarette smoking (CS) on a global level. While CS is most commonly associated with carcinomas of the upper and lower respiratory tracts, studies have also associated CS with the pathogenesis of a variety of non-respiratory related neoplasms. The tobacco smoke emitted from cigarettes contains carcinogenic substances that can be harmful to the normal physiology of the human body. Read More

Med Clin North Am 2019 May;103(3):463-473

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Unit 1462, 1515 Holcombe Boulevard, Houston, TX 77030, USA. Electronic address:

Lung cancer is the world's leading cause of cancer death. Screening for lung cancer by low-dose computed tomography improves mortality. Various modalities exist for diagnosis and staging. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):270-275

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

The diagnostic criteria of lung biopsy specimens by 2015 WHO lung tumor classification were used to evaluate lung biopsy specimens along with detection of genetic alterations of major tumor driving genes including epidermal growth factor receptor (EGFR). The clinical data, histological slides, immunohistochemical stains and special stains of 806 lung biopsy specimens at Beijing Hospital from July 2015 to July 2018 were retrospectively analyzed. Diagnosis of lung cancer was reclassified according to the 2015 WHO lung tumor classification and related gene mutation data were analyzed. Read More

BMC Syst Biol 2019 Apr 5;13(Suppl 2):26. Epub 2019 Apr 5.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Background: Biological experiments have confirmed the association between miRNAs and various diseases. However, such experiments are costly and time consuming. Computational methods help select potential disease-related miRNAs to improve the efficiency of biological experiments. Read More

Anticancer Res 2019 Apr;39(4):2193-2198

Department of Thoracic Surgery, Chubu Rosai Hospital, Nagoya, Japan.

Background/aim: Preoperative C-reactive protein (CRP) is well recognized as a prognostic factor of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the prognostic impact of postoperative CRP in patients with NSCLC following lung resection.

Patients And Methods: We retrospectively reviewed 336 patients with NSCLC treated with lung resection. Read More

Anticancer Res 2019 Apr;39(4):1987-1996

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background/aim: This study was performed to evaluate the influence of the body mass index (BMI) on disease-free survival and overall survival (DFS and OS) in patients with resected non-small cell lung cancer (NSCLC).

Patients And Methods: Overall, 546 of 780 (70%) patients with stage I to III NSCLC who underwent surgical resection were randomly selected. The patients were subdivided into three groups: low BMI (<18. Read More

Thorac Cancer 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, Chonnam National University Hospital, Chonnam National University School of Medicine, Gwangju, South Korea.

Glomus tumors are rare mesenchymal neoplasms arising from the glomus bodies in the deep dermis of the extremities or derive from the modified smooth muscle cells of the normal glomus body. Primary pulmonary glomus tumors are particularly rare and infrequently reported. We report a case of a primary glomus tumor occurring in the lung with adenocarcinoma in the ipsilateral lung as synchronous lung cancers in a 69-year-old man. Read More

Indian J Surg Oncol 2019 Mar 5;10(1):115-124. Epub 2018 Dec 5.

1Department of Orthopedic Surgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Oncological interventions in thoracic cavity have some important problems such as choice of correct operative approaches depending on the tumor, size, extension, and location. In sarcoma surgery, wide resection should be aimed for the curative surgery. Purpose of this study was to evaluate pre-operative planning of patient-specific thoracic cavity model made by multidisciplinary surgeon team for complex tumor mass for oncological procedures. Read More

Radiat Oncol J 2019 Mar 31;37(1):30-36. Epub 2019 Mar 31.

Division of Hematology and Oncology, Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Purpose: This study aimed to identify the feasibility of the maximum standardized uptake value (SUVmax) on baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) as a predictive factor for prognosis in early stage primary lung cancer treated with stereotactic body radiotherapy (SBRT).

Materials And Methods: Twenty-seven T1-3N0M0 primary lung cancer patients treated with curative SBRT between 2010 and 2018 were retrospectively evaluated. Four patients (14. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15099

Department of Respiratory Medicine, The Affiliated Hongqi Hospital of Mudanjiang Medical University, Mudanjiang.

Background: Non-small cell lung cancer (NSCLC) is the most common lung cancer. Numerous clinical studies have reported that the combination of carboplatin and S-1 (CS) can be used to treat NSCLC effectively. However, no systematic review has been conducted to assess its efficacy and safety for NSCLC. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15053

Department of Pathology, Qilu Hospital, Shandong University, Qingdao, China.

Rationale: Hepatoid adenocarcinoma of lung (HAL) is a rare malignant tumor, which can be defined as a primary alpha-fetoprotein (AFP)-producing lung carcinoma. The majority of hepatoid adenocarcinoma (HAC) expressed AFP in tumor cells, but AFP expression is not required for its diagnosis according to the modified diagnostic criteria. Despite that HAC exhibits a poor prognosis and ineffective treatment options, early diagnosis and aggressive treatment can result in long-term survival. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15039

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Rationale: Amyloidosis secondary to intrapulmonary Castleman disease (CD) is a rare benign disease diagnosed by histopathology. It seems to be associated with chronic inflammation, and large amounts of IL-6 produced in the germinal center of CD may enhance the production of precursor of amyloid.

Patient Concerns: We reported a case of an 18-year-old woman presenting with dry cough and dyspnea on exertion for 6 months and detailed exams revealed multiple pulmonary nodules, positive antinuclear antibodies, hypocomplementemia, and thrombocytopenia. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15031

Department of Respiratory and Critical Care Medicine, Beijing Shijitan Hospital, Capital Medical University.

Thin-wall cystic lung cancer is becoming of increasing interest in the study of pulmonary medicine. Consequently, more and more different images and pathologic manifestations have been found. The purpose of this article is to find pathologic characteristics and try to explain the formation mechanism of thin-walled cystic lung cancer. Read More

Medicine (Baltimore) 2019 Apr;98(14):e15020

Department of Oncology and Hematology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.

Rationale: Cardiac angiosarcoma is the most common malignant tumor of the heart and a rare disease with rapid disease progression and poor prognosis. Cardiac wall rupture is an extremely rare complication.

Patient Concerns: A 32-year-old woman presented with an acute onset of epigastric pain and chest discomfort at first time when she visited an emergency room. Read More

Medicine (Baltimore) 2019 Apr;98(14):e14979

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Background: Soluble mesothelin-related peptide (SMRP) is a widely studied tumor marker for diagnosing malignant pleural mesothelioma (MPM). This study discussed the diagnostic value of SMRPs in pleural effusion (PE) for MPM.

Methods: Medline, Embase, Web of Science, and Cochrane library system were systematically searched on the data of SMRPs in PE for MPM diagnosis. Read More

Medicine (Baltimore) 2019 Apr;98(14):e14972

Department of Internal Medicine.

Programmed death ligand 1 (PD-L1) immunohistochemistry (IHC) assays are widely used for complementary or companion diagnostic purposes during treatment with immune checkpoint inhibitors. However, limited information is available on the clinical reliability of the PD-L1 IHC assay using small biopsy samples.Participants included 46 patients with nonsmall cell lung cancer who underwent PD-L1 testing using 3 PD-L1 IHC assays (22C3, SP142, and SP263) for both small biopsy samples and surgical specimens from November 2017 to June 2018. Read More

BMC Cancer 2019 Apr 3;19(1):303. Epub 2019 Apr 3.

Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchondong, Seodaemun-gu, Seoul, 120-752, South Korea.

Background: Many factors influence bone metastases of lung cancer, and several studies report about survival of skeletal metastasis. However, few studies have focused on identifying the prognostic factors for skeletal metastasis of lung cancer, especially following orthopedic surgery. We conducted a retrospective analysis of the clinical characteristics of skeletal metastasis from lung cancer and discuss the prognostic factors. Read More

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiology, University of Iowa, 200 Hawkins Drive cc704 GH, Iowa City, IA, 52242, USA.

Objectives: Post-imaging mathematical prediction models (MPMs) provide guidance for the management of solid pulmonary nodules by providing a lung cancer risk score from demographic and radiologists-indicated imaging characteristics. We hypothesized calibrating the MPM risk score threshold to a local study cohort would result in improved performance over the original recommended MPM thresholds. We compared the pre- and post-calibration performance of four MPM models and determined if improvement in MPM prediction occurs as nodules are imaged longitudinally. Read More

J Clin Med Res 2019 Apr 18;11(4):275-282. Epub 2019 Mar 18.

Post-Graduate Program of Health Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Background: Cancer is a public health problem, especially in developing countries. In order to establish effective measures for the cancer control, there is a need for quality information, thus enabling a better understanding of the disease and its determinants, formulation of causal hypotheses, evaluation of the technological advances applied to prevention and treatment as well as the effectiveness of health care. The objective of the study was to investigate the prevalence of solid neoplasms diagnosed between the years 2011 to 2016 and treated at the Oncology Department of the University Hospital of Santa Maria and the existing oncological context. Read More

Cell Physiol Biochem 2019 ;52(4):742-757

Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada,

Background/aims: The oxidative stress sensor transient receptor potential melastatin-2 (TRPM2) ion channel has recently gained attention in many types of cancer. The lung tissue is highly susceptible to oxidative stress-mediated injury and diseases; therefore, we aimed to determine whether TRPM2 plays an essential role in protecting lung cancer cells from oxidative damage while promoting cancer cell survival and metastasis.

Methods: We used two non-small cell lung (NSCLC) cell lines A549 and H1299 as a lung cancer model. Read More

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

There is some evidence that place of residence is associated with cancer survival, but the findings are inconsistent, and the underlying mechanisms by which residential location might affect survival are not well understood. We conducted a systematic review of observational studies investigating the association of rural versus urban residence with cancer survival in high-income countries. We searched the Ovid Medline, EMBASE, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases up to May 31, 2016. Read More

Oncol Lett 2019 Apr 21;17(4):3997-4003. Epub 2019 Feb 21.

Department of Critical Care Medicine, Hospital do Câncer/UOPECCAN, Cascavel, Paraná 85806-300, Brazil.

Among onco-hematological patients with acute respiratory failure (ARpF), surgical lung biopsy (SLB) could contribute to the medical management, by guiding initiation, maintenance or discontinuation of diagnostic and therapeutic interventions. The aim of the present study was to evaluate the results of SLB in these patients in an oncological center from a medium-income country, as well as analyze if this procedure is clinically useful in this context, and its impact on complications and mortality. This observational retrospective study analyzed onco-hematological patients with ARpF in the Intensive Care Unit (ICU) of a cancer center in southern Brazil between 2010-2016, who required mechanical ventilation and were submitted to open SLB. Read More

Phys Med 2019 Mar 27;59:47-54. Epub 2019 Feb 27.

CyberKnife Unit, C.D.I. Centro Diagnostico Italiano S.p.A., Via Saint Bon 20, 20147 Milan, Italy.

Purpose: When a lung lesion is detected by only one couple of X-ray tube and image detector integrated with CyberKnife®, the fiducial-less tracking is limited to 1-view (34% of lung treatments at Centro Diagnostico Italiano). The aim of the study was mainly to determine the margin needed to take into account the localization uncertainty along the blind view (out-of-plane direction).

Methods: 36 patients treated in 2-view tracking modality (127 fractions in total) were included in the study. Read More

Phys Med 2019 Mar 26;59:37-46. Epub 2019 Feb 26.

Institute of Medical Physics, School of Physics, The University of Sydney, Sydney, New South Wales, Australia.

Purpose: To study the sensitivity of an Electronic Portal Imaging Device (EPID) in detecting delivery errors for VMAT lung stereotactic body radiotherapy (SBRT) using the Collapsed Arc method.

Methods: Baseline VMAT plans and plans with errors intentionally introduced were generated for 15 lung SBRT patients. Three types of errors were introduced by modifying collimator angles and multi-leaf collimator (MLC) field sizes (MLCFS) and MLC shifts by ±5, ±2, and ±1° or millimeters. Read More

Phys Med 2019 Mar 25;59:22-29. Epub 2019 Feb 25.

Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan.

Purpose: To improve respiratory gating accuracy and treatment throughput, we developed a fluoroscopic markerless tumor tracking algorithm based on a deep neural network (DNN).

Methods: In the learning stage, target positions were projected onto digitally reconstructed radiography (DRR) images from four-dimensional computed tomography (4DCT). DRR images were cropped into subimages of the target or surrounding regions to build a network that takes input of the image pattern of subimages and produces a target probability map (TPM) for estimating the target position. Read More

Phys Med 2019 Mar 9;59:100-106. Epub 2019 Mar 9.

Department of Health Sciences, Faculty of Life Sciences, Kumamoto University, 4-24-1 Kuhonji, Kumamoto, Japan.

The purpose of this study is to investigate the impact of inline magnetic field on dose distribution for volumetric modulated arc therapy (VMAT) in lung tumors located at the chest wall and mediastinum. Two VMAT plans for a thorax phantom with lung tumors of 1 cm and 2 cm in diameter located at the chest wall were created by a treatment planning system. Next, five clinical VMAT plans for a non-small cell lung cancer (NSCLC) at early stages I and II of 5 cm or less in diameter were also used. Read More

Clin Genitourin Cancer 2019 Feb 28. Epub 2019 Feb 28.

Radiation Oncology Department, La Pitié-Salpêtrière Universitary Hospital, Paris, France.

Background: The objective of the study was to evaluate the outcomes in terms of efficacy and safety of a large consecutive series of 362 patients with renal cell carcinoma (RCC) brain metastases treated using stereotactic radiosurgery (SRS) in the tyrosine kinase inhibitor (TKI) era.

Patients And Methods: From 2005 to 2015, 362 consecutive patients with brain metastases from RCC were treated using SRS in 1 fraction: 226 metastases (61 patients) using Gamma-Knife at a median of 18 Gy (50% isodose line); 136 metastases (63 patients) using linear accelerator at a median of 16 Gy (70% isodose line). The median patient age was 58 years. Read More

Pan Afr Med J 2018 27;31:60. Epub 2018 Sep 27.

Service d'Endocrinologie et Médecine Interne, Hôpital Tahar Sfar, Mahdia, Tunisie.

Corticosurrenaloma is a rare malignant tumor of the adrenal gland that often secretes corticosteroids, sex steroids and precursors. Aldosterone-producing corticosurrenaloma is very rare, accounting for 1 case/10million inhabitants. We report the case of a 38-year old man presenting with severe arterial hypertension associated with deep hypokalaemia (2. Read More

Mod Pathol 2019 Mar 28. Epub 2019 Mar 28.

Thoracic Oncology Service, Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The spectrum and evolution of proliferation rates in stage IV lung carcinoids is poorly defined. In particular, there are limited data on the prevalence and characteristics of tumors exceeding the standard upper proliferative criteria-as defined largely based on early-stage carcinoids-in metastatic setting. Sixty-six patients with stage IV lung carcinoids were identified, and all evaluable samples (n = 132; mean 2 samples per patient) were analyzed for mitotic counts and Ki-67 rate. Read More

Kyobu Geka 2019 Mar;72(3):240-243

Department of Thoracic Surgery, Sapporo City General Hospital, Sapporo, Japan.

We suspected Birt-Hogg-Dubé syndrome (BHDS) from intraoperative findings of emergency operation for idiopathic hemopneumothorax. A 34-year-old man was delivered to our center due to sudden chest pain and dyspnea. Under the diagnosis of hemopneumothorax, emergency operation was performed. Read More

Kyobu Geka 2019 Mar;72(3):167-172

Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.

Background: Only a few studies have examined the effects of regular acetaminophen drip infusion as postoperative analgesia in lung cancer surgery.

Methods: We consecutively collected the medical data of 282 patients who underwent complete resection for lung cancer and divided them into 2 groups according to their postoperative analgesia;248 patients with conventional analgesia( group C) and 34 who received acetaminophen( group A).

Results: There was no significant difference in the surgical approach, length of surgical incision, or postoperative pain scale between the 2 groups. Read More

BMJ 2019 Mar 28;364:l1049. Epub 2019 Mar 28.

Queen's University Belfast; and Belfast Health and Social Care Trust, Belfast, UK.

Medicine (Baltimore) 2019 Mar;98(13):e15078

Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Acute lung injury following lung resection surgery is not rare and often related to mortality. Although it has been a significant clinical and economic impact associated with increased intensive care unit (ICU) utilization, length of hospital stay, and associated cost, it is unpredictable. Aims of this study were to identify the modifiable risk factors of postoperative acute lung injury (PALI) following lung cancer surgery. Read More