177,408 results match your criteria Neoplasms Brain


Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
1 Read

Chromothripsis - Extensive Chromosomal Rearrangements and Their Significance in Cancer.

Klin Onkol 2019 ;32(2):101-108

Background: Chromosome rearrangements play an important role in cancer pathophysiology. Recently, chromothripsis has been proposed among the mechanisms leading to their formation. Chromothripsis leads to fragmentation of chromosomes and their reconstitution with tens to hundreds of rearrangements clustered in small genome regions. Read More

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https://www.linkos.cz/english-summary/klinicka-onkologie-jou
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http://dx.doi.org/10.14735/amko2019101DOI Listing
January 2019
2 Reads

Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome.

BMC Cancer 2019 Apr 16;19(1):362. Epub 2019 Apr 16.

Department of Gastroenterology and Endocrinology, University Hospital Marburg, Baldinger Strasse, 35043, Marburg, Germany.

Background: Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. However, symptomatic brain metastases are associated with dismal prognosis, so early detection and treatment could be advisable.

Methods: We retrospectively analyzed 51 patients with GEP-NEN and bronchopulmonary NEN excluding small cell lung cancer. Read More

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http://dx.doi.org/10.1186/s12885-019-5559-7DOI Listing
April 2019
1 Read

Papillary Tumor of the Pineal Region: Systematic Review and Analysis of Prognostic Factors.

Neurosurgery 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurosurgery, School of Medicine, Universidade de Sao Paulo, Sao Paulo, Brazil.

Background: Clinical outcomes and biological behavior of papillary tumors of the pineal region (PTPR) are still under investigation. The best therapeutic strategy has not been defined.

Objective: To perform a comprehensive patient-level analysis of all PTPR cases and identify their clinical features, treatment options, and prognostic factors. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyz062DOI Listing
April 2019
6 Reads

Biomarkers of Pineal Region Tumors: A Review.

Ochsner J 2019 ;19(1):26-31

Department of Neurological Surgery, Ochsner Clinic Foundation, New Orleans, LA.

The pineal gland, a small, pinecone-shaped organ deep within the brain, is responsible for producing melatonin. The gland consists of pineal parenchymal cells and glial cells that can form neoplasms. Pineal region neoplasms can also arise from germ cells and adjacent structures. Read More

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http://dx.doi.org/10.31486/toj.18.0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447205PMC
January 2019

Immunotherapy in gliomas: Are we reckoning without the innate immunity?

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419843378

4 Department of Health Sciences, University of Catanzaro "Magna Graecia," Catanzaro, Italy.

Innate immunity plays a central role in neoplasms, including those affecting the central nervous system (CNS). Nowadays, tumors classification, especially that regarding gliomas, is based on molecular features such as mutations in isocitrate dehydrogenase (IDH) genes and the presence of co-deletion 1p/19q. Therapy, in most cases, is based on surgery, radiotherapy, and pharmacological treatment with chemotherapeutic agents such as temozolomide. Read More

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http://journals.sagepub.com/doi/10.1177/2058738419843378
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http://dx.doi.org/10.1177/2058738419843378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458670PMC
April 2019
7 Reads

Epigenetic Classifiers for Precision Diagnosis of Brain Tumors.

Epigenet Insights 2019 31;12:2516865719840284. Epub 2019 Mar 31.

Cancer Epigenetics Laboratory, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.

DNA methylation profiling has proven to be a powerful analytical tool, which can accurately identify the tissue of origin of a wide range of benign and malignant neoplasms. Using microarray-based profiling and supervised machine learning algorithms, we and other groups have recently unraveled DNA methylation signatures capable of aiding the histomolecular diagnosis of different tumor types. We have explored the methylomes of metastatic brain tumors from patients with lung cancer, breast cancer, and cutaneous melanoma and primary brain neoplasms to build epigenetic classifiers. Read More

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http://dx.doi.org/10.1177/2516865719840284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444760PMC
March 2019
1 Read

Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.

Diagn Pathol 2019 Apr 9;14(1):29. Epub 2019 Apr 9.

Knight Diagnostic Laboratories and Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, USA.

Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, including gene mutations, chromosomal copy number alterations, and gene rearrangements. In 2016, the World Health Organization provided guidelines for making an integrated diagnosis that incorporates both morphologic and molecular features in a subset of brain tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0802-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457044PMC
April 2019
1 Read

An update on the central nervous system manifestations of neurofibromatosis type 1.

Acta Neuropathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology, Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA.

Neurofibromatosis 1 (NF1) is an autosomal dominant genetic disorder that presents with variable phenotypes as a result of mutations in the neurofibromatosis type 1 (NF1) gene and subsequently, abnormal function of the protein product, neurofibromin. Patients with NF1 are at increased risk for central nervous system (CNS) manifestations including structural, functional, and neoplastic disease. The mechanisms underlying the varied manifestations of NF1 are incompletely understood, but the loss of functional neurofibromin, resulting in sustained activation of the oncoprotein RAS, is responsible for tumorigenesis throughout the body, including the CNS. Read More

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http://dx.doi.org/10.1007/s00401-019-02002-2DOI Listing
April 2019
1 Read

Survival and quality of life after whole brain radiotherapy with 3D conformal boost in the treatment of brain metastases.

Med Pharm Rep 2019 Jan 15;92(1):43-51. Epub 2019 Jan 15.

Oncology-Radiotherapy Department, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.

Background: Brain metastases are the most frequent intracranial neoplasms in adults. Although overall survival (OS) is an important endpoint in patients receiving radiotherapy, given their poor life expectancy in general, quality of life is becoming an increasingly useful endpoint. Objectives: to evaluate whole brain radiotherapy (WBRT) with 3D conformal boost in brain metastases patients with regard to OS and quality of life. Read More

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http://dx.doi.org/10.15386/cjmed-1040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448499PMC
January 2019
2 Reads

Estimating Survival of Patients With Metastatic Renal Cell Carcinoma Receiving Whole-brain Radiotherapy With a New Tool.

Anticancer Res 2019 Apr;39(4):2091-2095

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Background/aim: A new tool for estimating survival of patients receiving whole-brain radiotherapy (WBRT) for intracerebral metastases from renal cell carcinoma (RCC) was created.

Patients And Methods: The new WBRT-30-RCC was developed in 34 patients homogeneously treated with 30 Gy in 10 fractions of WBRT and compared to updated diagnosis-specific graded prognostic assessment DS-GPA and Dziggel score for predicting death within 6 months and survival for at least 6 months following WBRT.

Results: WBRT-30-RCC included three groups with 6-month survival rates of 6. Read More

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http://dx.doi.org/10.21873/anticanres.13321DOI Listing
April 2019
3 Reads

Immune Phenotype Correlates With Survival in Patients With GBM Treated With Standard Temozolomide-based Therapy and Immunotherapy.

Anticancer Res 2019 Apr;39(4):2043-2051

Institute of Communication and Computer Systems, School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.

Background/aim: The need for more effective treatment modalities that can improve the clinical outcome of patients with glioblastoma multiforme remains imperative. Dendritic cell vaccination is a fast-developing treatment modality, currently under exploration. Functional immune cell subpopulations may play a role in the final outcome. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13315DOI Listing
April 2019
5 Reads

Chordomas: Histopathological Study in View of Anatomical Location.

J Korean Med Sci 2019 Apr 8;34(13):e107. Epub 2019 Apr 8.

Department of Pathology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.

Background: Chordomas are aggressive bone tumors that have a predilection for the axial skeleton including the skull base and spinal/sacral bones. However, the histopathological and clinical differences between skull base chordoma (SBC) and sacral/spinal chordoma (SC) are unclear as previous studies have been focused on patient prognosis and treatment outcome. This study aimed to evaluate the clinicopathologic features and prognosis of chordoma according to its location. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449597PMC
April 2019
2 Reads

Cerebellopontine angle ependymoma in a young adult: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15019

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Rationale: Cerebellopontine angle (CPA) ependymomas are atypical kind of ependymomas that characteristically occur in the pediatric age group. Therefore, finding a case of CPA ependymoma in a young male adult is not a common occurrence.

Patient Concerns: We present a case of a 28-year-old male who was involved in road traffic accident with suspected mild head injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000015019DOI Listing
April 2019
2 Reads

Pilomyxoid astrocytomas: a short review.

Brain Tumor Pathol 2019 Apr 3. Epub 2019 Apr 3.

Neuropathology Division, Department of Pathology, UCSF School of Medicine, Moffitt, M551C, University of California, 505 Parnassus Avenue, Box 0102, San Francisco, CA, 94143, USA.

Pilomyxoid astrocytoma is a variant of pilocytic astrocytoma and the clinical, histological and molecular data point to a very close relationship as well as a more aggressive biological behavior for the former. WHO 2016 classification does not provide a specific grade for these neoplasms, but there is sufficient evidence in the literature that pilomyxoid astrocytoma has slightly worse prognosis than typical pilocytic astrocytoma. There is increasing evidence that in addition to the MAPK pathway alterations, pilomyxoid astrocytomas harbor genetic alterations that distinguish them from typical pilocytic astrocytoma. Read More

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http://link.springer.com/10.1007/s10014-019-00343-0
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http://dx.doi.org/10.1007/s10014-019-00343-0DOI Listing
April 2019
4 Reads

Low expression of pentraxin 3 and nuclear factor-like 2 implying a relatively longer overall survival time in gliomas.

Chin J Physiol 2019 Jan-Feb;62(1):35-43

Department of Pathology, Tri-Service General Hospital; Graduate Institute of Pathology and Parasitology, National Defense Medical Center, Taipei, Taiwan.

Pentraxin 3 (PTX3) and nuclear factor-like 2 (Nrf2) are known to induce tumor progression in certain malignancies but act as tumor suppressors in other human neoplasms. In this study, we not only tested the association between PTX3 expression and the World Health Organization (WHO) tumor grading system but also evaluated overall patient survival under variable expression of PTX3 and Nrf2 in primary brain tumors (PBTs). Immunohistochemistry (IHC) was performed for PTX3 and Nrf2 in 10 nonneoplastic brain tissues and 197 PBTs. Read More

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http://dx.doi.org/10.4103/CJP.CJP_3_19DOI Listing
April 2019
3 Reads

Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study.

J Breast Cancer 2019 Mar 20;22(1):120-130. Epub 2018 Dec 20.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to evaluate the risk of central nervous system (CNS) failure in Korean patients with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer treated with surgery followed by postoperative radiotherapy (RT).

Methods: A total of 749 patients from eight institutions were enrolled in this study. All of them underwent surgery followed by postoperative RT from 2003 to 2011; 246 (32. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4048/jbc.2019.22
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http://dx.doi.org/10.4048/jbc.2019.22.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438829PMC
March 2019
5 Reads
1.317 Impact Factor

A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour.

Childs Nerv Syst 2019 Apr 2. Epub 2019 Apr 2.

Neurosurgical Service, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Purpose: Diffuse leptomeningeal glioneuronal tumour (DLGNT) is an extremely rare tumour involving the neuroaxis. At present, its exact pathogenesis and associated factors remain incompletely characterised. Recent molecular investigations in a small cohort have offered some insights into this disease. Read More

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http://dx.doi.org/10.1007/s00381-019-04128-wDOI Listing

Adult Pilomyxoid Astrocytoma with Hemorrhage in an Atypical Location.

Asian J Neurosurg 2019 Jan-Mar;14(1):300-303

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pilomyxoid astrocytomas (PMAs) are generally seen in young children and tend to occur in the hypothalamic-chiasmatic region. Their presence in other parts of the brain in the nonpediatric age group is uncommon. In addition, hemorrhage in such low-grade tumors is an occasional event. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_164_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417295PMC
April 2019
2 Reads

Primary vitreoretinal lymphoma.

Saudi J Ophthalmol 2019 Jan-Mar;33(1):66-80. Epub 2019 Jan 14.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Primary vitreoretinal lymphoma (PVRL) is a rare ocular lymphoid malignancy, which consists a subset of primary central system lymphoma (PCNSL) and the most common type of intraocular lymphoma. The involvement of eyes is estimated to be approximately 20% of PCNSL, but the brain involvement may be up to 80% of PVRL. Typically, PVRL is a high grade B-cell malignancy of the retina and needs to be assorted from choroidal low-grade B-cell lymphomas. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424706PMC
January 2019
2 Reads

Golden-angle radial sparse parallel (GRASP) MRI in clinical routine detection of pituitary microadenomas: First experience and feasibility.

Magn Reson Imaging 2019 Mar 27;60:38-43. Epub 2019 Mar 27.

Department of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Division of Diagnostic and Interventional Neuroradiology, Department of Radiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Background and purpose To demonstrate the clinical feasibility of a novel MRI pulse sequence, Golden-angle radial sparse parallel MRI (GRASP) through comparison to the current imaging technique, dynamic T1- weighted contrast enhanced (DCE) imaging in terms of image quality and lesion depiction in the detection of microlesions (microadenomas and cysts) of the pituitary gland.

Materials And Methods: 16 patients (11 microadenomas, 5 cysts) underwent two MRI examinations (Siemens 1.5T and 3T) on separate dates, one using standard DCE (temporal resolution 30 s) and the other using GRASP (temporal resolution of 4. Read More

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http://dx.doi.org/10.1016/j.mri.2019.03.015DOI Listing

Stereotactic Radiation Therapy for Renal Cell Carcinoma Brain Metastases in the Tyrosine Kinase Inhibitors Era: Outcomes of 120 Patients.

Clin Genitourin Cancer 2019 Feb 28. Epub 2019 Feb 28.

Radiation Oncology Department, La Pitié-Salpêtrière Universitary Hospital, Paris, France.

Background: The objective of the study was to evaluate the outcomes in terms of efficacy and safety of a large consecutive series of 362 patients with renal cell carcinoma (RCC) brain metastases treated using stereotactic radiosurgery (SRS) in the tyrosine kinase inhibitor (TKI) era.

Patients And Methods: From 2005 to 2015, 362 consecutive patients with brain metastases from RCC were treated using SRS in 1 fraction: 226 metastases (61 patients) using Gamma-Knife at a median of 18 Gy (50% isodose line); 136 metastases (63 patients) using linear accelerator at a median of 16 Gy (70% isodose line). The median patient age was 58 years. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.02.007DOI Listing
February 2019
1 Read

Posterior occipital intramuscular hemangioma mimicking arteriovenous malformation: Case report.

Medicine (Baltimore) 2019 Mar;98(13):e14678

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China.

Rationale: Intermuscular hemangioma (IH) usually occurs in the muscles of the limbs and trunk, but can rarely occur in the occipital region. IH in the occipital region is easily misdiagnosed as arteriovenous malformation (AVM).

Patient Concerns: A 31-year-old woman had a right occipital mass for 5 months without pulsation. Read More

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http://dx.doi.org/10.1097/MD.0000000000014678DOI Listing
March 2019
2 Reads

Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.

Curr Oncol Rep 2019 Mar 27;21(5):40. Epub 2019 Mar 27.

Department of Neurology, Indiana University Health, Indiana University School of Medicine, 355 W. 16th St., Ste 3200, Indianapolis, IN, 46202, USA.

Purpose Of Review: Peripheral natural killer (NK) and T cell neoplasms comprise approximately 10-15% of non-Hodgkin lymphomas. There are 27 different subtypes of peripheral NK and T cell neoplasms, each of which is relatively uncommon. Treatment has been largely extrapolated from case series, retrospective reports, and paradigms developed for the aggressive B cell lymphomas. Read More

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http://link.springer.com/10.1007/s11912-019-0794-2
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http://dx.doi.org/10.1007/s11912-019-0794-2DOI Listing
March 2019
2 Reads

Clinical outcome of cerebrospinal fluid shunts in patients with leptomeningeal carcinomatosis.

World J Surg Oncol 2019 Mar 27;17(1):59. Epub 2019 Mar 27.

Neuro-oncology Clinic, National Cancer Center, Goyang, Republic of Korea.

Background: Leptomeningeal carcinomatosis (LMC) is frequently associated with hydrocephalus, which quickly devastates the performance of the patient. Cerebrospinal fluid (CSF) shunt is a widely accepted treatment of choice, but the clinical outcomes in patients with LMC are not well studied. This study aimed to examine the efficacy of a CSF shunt in patients with LMC. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1595-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438037PMC
March 2019
6 Reads

[The effect of downregulation of MCT1 on the proliferation of glioma cells].

Zhonghua Zhong Liu Za Zhi 2019 Mar;41(3):208-213

the Third Ward of Neurosurgery, Nanyang Central Hospital, Nanyang 473000, China.

To investigate the molecular mechanism of down-regulation of monocarboxylic acid transporter 1 (MCT1) on the proliferation inhibition of glioma cell. siMCT1, siMCT4 and negative control siRNA were transfected into glioma cell lines including U-251 and U-87. The proliferation activities of U-251 and U-87 cells were detected by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT) assay and clonogenic assay. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.03.010DOI Listing
March 2019
4 Reads

Clear Cell Sarcoma of the Kidney.

Arch Pathol Lab Med 2019 Mar 27. Epub 2019 Mar 27.

From the Division of Anatomical Pathology, University of Cape Town, Cape Town, and the National Health Laboratory Service, Western Cape, South Africa (Drs Aldera and Pillay); the Department of Anatomical Pathology, Groote Schuur Hospital, Western Cape, South Africa (Dr Aldera); and the Department of Anatomical Pathology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa (Dr Pillay).

Clear cell sarcoma of the kidney is an uncommon malignant pediatric renal neoplasm that typically presents in the 2- to 3-year age group and has a propensity for aggressive behavior and late relapses. Histologically, this tumor exhibits a great diversity of morphologic patterns which can mimic most other pediatric renal neoplasms, often leading to confusion and misdiagnosis. Until recently, adjunct immunohistochemical and molecular genetic tests to support the diagnosis were lacking. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2018-035
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http://dx.doi.org/10.5858/arpa.2018-0353-RSDOI Listing
March 2019
3 Reads

[Association between the HER2 Gene Status and the Efficacy of First-line Pemetrexed Combined with Platinum Chemotherapy in Patients with Advanced Lung 
Adenocarcinoma].

Zhongguo Fei Ai Za Zhi 2019 Mar;22(3):137-142

Department of Medical Oncology, the First Affiliated Hospital of Zhengzhou University, 
Zhengzhou 450052, China.

Background: Human epidermal growth factor receptor 2 (HER2) is one of the driver genes of non-small cell lung cancer (NSCLC). Several studies have shown that the efficacy of pemetrexed in HER2-mutant NSCLC is controversial. The aim of this study is to investigate the efficacy of pemetrexed combined with platinum chemotherapy in patients with HER2-mutant and HER2 wild-type lung adenocarcinoma. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.03.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441116PMC
March 2019
1 Read

Application of a machine learning method to whole brain white matter injury after radiotherapy for nasopharyngeal carcinoma.

Cancer Imaging 2019 Mar 25;19(1):19. Epub 2019 Mar 25.

Medical Imaging Center, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China.

Background: The purpose/aim of this study was to 1) use magnetic resonance diffusion tensor imaging (DTI), fibre bundle/tract-based spatial statistics (TBSS) and machine learning methods to study changes in the white matter (WM) structure and whole brain WM network in different periods of the nasopharyngeal carcinoma (NPC) patients after radiotherapy (RT), 2) identify the most discriminating WM regions and WM connections as biomarkers of radiation brain injury (RBI), and 3) supplement the understanding of the pathogenesis of RBI, which is useful for early diagnosis in the clinic.

Methods: A DTI scan was performed in 77 patients and 67 normal controls. A fractional anisotropy map was generated by DTIFit. Read More

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http://dx.doi.org/10.1186/s40644-019-0203-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434635PMC
March 2019
1 Read

New research directions in medulloblastoma.

Neurochirurgie 2019 Mar 20. Epub 2019 Mar 20.

Équipe "Signalisation, développement et tumeurs cérébrales", unité Inserm U1021, Institut Curie, université Paris-Saclay, 15, rue Georges-Clémenceau, Orsay, France.

Introduction: Medulloblastoma is the most common type of pediatric malignant brain tumor where the most important amount of clinical and radiological data has been accumulated in recent years. This has led to its sophistication in the management of these patients with a clear benefit for the patients. Long-term outcome and sequelae have been described and their causes well understood such as preventive measures which can now be implemented. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283770193002
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http://dx.doi.org/10.1016/j.neuchi.2019.01.002DOI Listing
March 2019
7 Reads

Comparison of the incidence of new malignancies in diabetic patients in urban and rural populations in Poland in the years 2008-2014 based on the database of the National Health Fund.

Arch Med Sci 2019 Mar 5;15(2):330-336. Epub 2017 Oct 5.

Department of Health Care, Center of Postgraduate Medical Education, Warsaw, Poland.

Introduction: Many epidemiological studies show a correlation between the risk of cancer and type 2 diabetes mellitus in various populations.

Material And Methods: The material was obtained from the database of the National Health Fund. This publication presents a comparison of the incidence of new malignancies in rural and urban populations of diabetic patients in Poland based on the database of the National Health Fund for the period between 1. Read More

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http://dx.doi.org/10.5114/aoms.2017.68409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425219PMC
March 2019
2 Reads

Genotype-phenotype correlation in 99 familial adenomatous polyposis patients: A prospective prevention protocol.

Cancer Med 2019 Mar 21. Epub 2019 Mar 21.

Cancer Genetics, Oncology Department, Sírio Libanes Hospital, São Paulo, Brazil.

Background: Familial adenomatous polyposis (FAP) is a syndrome caused by germline pathogenic variants in the tumor suppressor gene adenomatous polyposis coli (APC). Identification of APC pathogenic variants sites and the genotype-phenotype correlation are important for characterizing, monitoring, and treating members of affected families. The aim of this study was to correlate genotype-phenotype of Brazilian individuals carrying APC pathogenic germline variants and that have FAP. Read More

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http://dx.doi.org/10.1002/cam4.2098DOI Listing
March 2019
4 Reads

Cerebral embolism during edoxaban administration for venous thromboembolism in a patient with lung adenocarcinoma: A case report.

Medicine (Baltimore) 2019 Mar;98(12):e14821

Department of Respiratory Internal Medicine, Hiroshima University Hospital, Minami-ku, Hiroshima, Japan.

Rationale: The efficacy of direct oral anticoagulants (DOACs) in the treatment and prophylaxis of cancer-related venous thromboembolism (VTE) is reportedly similar to that of heparin. However, the effect of DOACs on the prophylaxis of cancer-related arterial thromboembolism (ATE) remains unclear. To our knowledge, we present the 1st case where cerebral ATE was encountered during edoxaban administration for VTE in a patient with lung adenocarcinoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000014821DOI Listing
March 2019
1 Read

Choroid plexus tumours on MRI: similarities and distinctions in different grades.

Cancer Imaging 2019 Mar 20;19(1):17. Epub 2019 Mar 20.

Medical Imaging Center, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, No. 16, Ji Chang Lu, Guangzhou, 510405, People's Republic of China.

Background: The therapeutic planning varies for different grades of choroid plexus tumours (CPTs). The aim of this study was to define the similarities and distinctions among MRIs for different grades of CPTs, providing more guidance for clinical decisions.

Methods: We reviewed the MRI findings in 35 patients with CPT verified by surgical pathology, including 18 choroid plexus papillomas (CPPs, grade I), 11 atypical choroid plexus papillomas (aCPPs, grade II), and 6 choroid plexus carcinomas (CPCs, grade III). Read More

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http://dx.doi.org/10.1186/s40644-019-0200-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427869PMC
March 2019
1 Read

Optimizing Postoperative Surveillance of Pediatric Low-Grade Glioma Using Tumor Behavior Patterns.

Neurosurgery 2019 Mar 20. Epub 2019 Mar 20.

Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts.

Background: Pediatric low-grade gliomas are among the most common childhood neoplasms, yet their post-treatment surveillance remains nonstandardized, relying on arbitrarily chosen imaging intervals.

Objective: To optimize postoperative magnetic resonance imaging (MRI) surveillance protocols for pediatric low-grade gliomas.

Methods: Patients aged 0 to 21 yr with pediatric low-grade gliomas, treated between 1990 and 2016 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1093/neuros/nyz072DOI Listing

Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):136-140

Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, SP, Brasil.

We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.136DOI Listing
February 2019
1 Read
0.915 Impact Factor

Neurological toxicities associated with chimeric antigen receptor T-cell therapy.

Brain 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chimeric antigen receptor T cell therapy has become an important tool in the treatment of relapsed and refractory malignancy; however, it is associated with significant neurological toxicity. We characterized the neurological toxicity associated with chimeric antigen receptor T-cell therapy in a consecutive series of 100 patients up to 2 months post transfusion, 28 of whom were obtained from chart review and the others by prospective observation. The underlying neoplasms were lymphoma (74%), myeloma (14%), leukaemia (10%), and sarcoma (2%). Read More

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http://dx.doi.org/10.1093/brain/awz053DOI Listing
March 2019
3 Reads
9.196 Impact Factor

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.

Nat Commun 2019 03 19;10(1):1262. Epub 2019 Mar 19.

Department of Human Genetics, McGill University, Montreal, QC, H3A 1B1, Canada.

Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and in vivo. We find that whereas H3K27me3 and H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced in H3. Read More

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http://dx.doi.org/10.1038/s41467-019-09140-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425035PMC
March 2019
5 Reads
10.742 Impact Factor

Psychopathological Influence of Middle Fossa Arachnoid Cysts in Young Men: Analysis of Korean Conscription Data.

World Neurosurg 2019 Feb 25;122:e530-e539. Epub 2018 Oct 25.

Department of Neurosurgery, College of Medicine, Chung-Ang University, Seoul, Korea.

Background: A few reported studies have documented psychotic syndromes secondary to a middle fossa arachnoid cyst (AC). However, the association between middle fossa ACs and psychopathological symptoms remains to be determined. The present study investigated the psychopathological effects of middle fossa ACs in young men. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.095DOI Listing
February 2019
3 Reads

Metastases of ductal carcinoma of the breast in the esophagus. Case report

Rev Med Inst Mex Seguro Soc 2019 Mar 15;56(6):562-565. Epub 2019 Mar 15.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez, Servicio de Anatomía Patológica. Ciudad de México, México

Background: Invasive breast cancer is the most common carcinoma in women, 23% of all cancers in the world. It is classified according to its histological pattern and expression of immunohistochemical markers; 75% are ductal type. The incidence of metastases is 10 to 80% of the cases according to their immunophenotype, the main sites of metastases are bone, visceral and brain. Read More

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March 2019
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Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

Eur Radiol 2019 Mar 19. Epub 2019 Mar 19.

Department of Radiology, School of Clinical Medicine, University of Cambridge, Box 218, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.

Purpose: This prospective study evaluated the use of vascular, extracellular and restricted diffusion for cytometry in tumours (VERDICT) MRI to investigate the tissue microstructure in glioma. VERDICT-derived parameters were correlated with both histological features and tumour subtype and were also used to explore the peritumoural region.

Methods: Fourteen consecutive treatment-naïve patients (43. Read More

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http://dx.doi.org/10.1007/s00330-019-6011-8DOI Listing

Pre-operative apparent diffusion coefficient values and tumour region volumes as prognostic biomarkers in glioblastoma: correlation and progression-free survival analyses.

Insights Imaging 2019 Mar 18;10(1):36. Epub 2019 Mar 18.

Directorate of Research, Secretariat of Health, General Hospital of Mexico, Mexico City, Mexico.

Objectives: Glioblastoma (GB) contains diverse histologic regions. Apparent diffusion coefficient (ADC) values are surrogates for the degree of number of cells within the tumour regions. Because an assessment of ADC values and volumes within tumour sub-compartments of GB is missing in the literature, we aimed to evaluate these associations. Read More

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http://dx.doi.org/10.1186/s13244-019-0724-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423260PMC
March 2019
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Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors.

Cancer Imaging 2019 Mar 18;19(1):14. Epub 2019 Mar 18.

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, USA.

Purpose: To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI.

Methods: MRI imaging was retrospectively assessed on one hundred and fourteen (N = 114) brain metastases including breast (n = 27), non-small cell lung cancer (NSCLC, n = 43) and 'other' primary tumors (n = 44). Based on 114 patient's MRI scans, a total of 346 individual contrast enhancing tumors were manually segmented. Read More

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http://dx.doi.org/10.1186/s40644-019-0201-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423873PMC
March 2019
2 Reads

Clinicopathological and prognostic significance of p16 protein in nasopharynx cancer patients: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2019 Mar;98(11):e14602

Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital.

Background: p16 protein is significantly down-regulated in several cancers, which reveals that it may be a potential biomarker for cancers. However, the clinicopathological and prognostic value of p16 protein in nasopharynx cancer patients remains unclear. Therefore, we performed a meta-analysis to assess the relationships of p16 protein expression with the clinicopathological features and prognosis of nasopharynx cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426621PMC
March 2019
5 Reads

Results of 31-P-MR-spectroscopy for brain metastases correlates with histopathological results.

World Neurosurg 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria.

Background: Brain metastases (BM) are classically well-circumscribed lesions. Still, the amount of edema in these neoplasms suggested either mechanisms of infiltration or defense. A better understanding of the mechanisms within the edema of BM seems reasonable, to preoperatively identify areas of potential infiltration and resect them. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.041DOI Listing
March 2019
1 Read

Association between tea and coffee consumption and brain cancer risk: an updated meta-analysis.

World J Surg Oncol 2019 Mar 15;17(1):51. Epub 2019 Mar 15.

Department of Neurology, Tianjin First Center Hospital, No. 24, Fukang Road, Nankai District, Tianjin, 300192, China.

Background: Previous studies had demonstrated some associations between coffee and tea consumption and brain cancer risk resulted in an inconsistent relationship. We therefore performed this study to further explore the association between them.

Method: By searching PubMed, Embase, and Web of Science, we retrieved up to 1 November 2018, 11 relevant literature of publications were collected by 2 people eventually. Read More

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http://dx.doi.org/10.1186/s12957-019-1591-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419842PMC
March 2019
1 Read

Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression.

Cancer Invest 2019 15;37(2):67-72. Epub 2019 Mar 15.

c Department of Oncology , Johns Hopkins University , Baltimore , MD , USA.

There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. Read More

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http://dx.doi.org/10.1080/07357907.2018.1564927DOI Listing
March 2019
3 Reads

Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase inhibitor discontinuation: An autopsy report.

Neuropathology 2019 Apr 13;39(2):147-155. Epub 2019 Mar 13.

Department of Pathology, Mitsui Memorial Hospital, Tokyo, Japan.

Miliary brain metastasis is a rare type of brain metastasis, in which carcinoma cells disseminate to numerous foci confined to Virchow-Robin/subpial spaces. Symptoms usually progress within several months, and magnetic resonance imaging (MRI) shows multiple small contrast-enhancing lesions. We report an autopsy case of a patient who rapidly deteriorated within a week due to miliary brain metastasis after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) discontinuation, without contrast-enhancing lesions on MRI. Read More

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http://dx.doi.org/10.1111/neup.12542DOI Listing
April 2019
2 Reads

Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.

Pediatr Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York City, New York.

Neurocutaneous melanosis (NCM) is the condition of abnormal melanocyte deposition in the leptomeninges and brain parenchyma. Associated with congenital melanocytic nevi, NCM can result in neurologic deficits, hydrocephalus, and rarely, malignant transformation of cells. We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor. Read More

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http://dx.doi.org/10.1111/pde.13804DOI Listing
March 2019
4 Reads

Improving cancer symptom awareness and help-seeking among adults living in socioeconomically deprived communities in the UK using a facilitated health check: A protocol for the Awareness and Beliefs About Cancer (ABACus) Randomised Control Trial.

BMC Public Health 2019 Mar 11;19(1):285. Epub 2019 Mar 11.

Division of Population Medicine, School of Medicine, Cardiff University, Neuadd Meirionnydd, Heath Park, Cardiff, CF14 4YS, UK.

Background: Cancer survival is lower in socioeconomically deprived communities, partly due to low awareness of symptoms, negative beliefs and delayed help-seeking. We developed an interactive health check questionnaire facilitated by trained lay advisors. It entails 29 questions about background, lifestyle and health with tailored behaviour change advice. Read More

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http://dx.doi.org/10.1186/s12889-019-6612-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417119PMC
March 2019
4 Reads