175,997 results match your criteria Neoplasms Brain


Neurocytoma mimicking macroadenoma.

Surg Neurol Int 2019 21;10. Epub 2019 Jan 21.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Background: Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20-40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases.

Case Description: The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. Read More

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http://dx.doi.org/10.4103/sni.sni_387_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357540PMC
January 2019

Quality of Life in Brain Cancer: Clinical Validation of the Mexican-Spanish Version of the EORTC QLQ-BN20 Questionnaire.

Front Neurol 2019 30;10:40. Epub 2019 Jan 30.

Subdirección de Investigación Clínica, Instituto Nacional de Cancerología, Mexico City, Mexico.

Overall survival (OS) of patients with Brain Cancer (BC) is slowly increasing. The disease itself and its treatments deeply impact patient Health-related quality of life (HRQL). Therefore, valid and reliable instruments are needed. Read More

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http://dx.doi.org/10.3389/fneur.2019.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363944PMC
January 2019
1 Read

Coexistence of intracranial solitary fibrous tumor/hemangiopericytoma and right middle cerebral artery aneurysm.

J Surg Case Rep 2019 Jan 31;2019(1):rjz013. Epub 2019 Jan 31.

Department of Radiology, Section of Neuroradiology Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.

Intracranial solitary fibrous tumors are rare mesenchymal neoplasms originating in the meninges and constitute a heterogeneous group of rare spindle cell tumors that include benign and malignant neoplasms of which hemangiopericytoma is nowadays considered a cellular phenotypic variant. From literatures, the incidence of coexistence of brain tumors and intracranial aneurysms is ~0.7-5. Read More

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http://dx.doi.org/10.1093/jscr/rjz013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354750PMC
January 2019
1 Read

Intratumoural Heterogeneity Underlies Distinct Therapy Responses and Treatment Resistance in Glioblastoma.

Cancers (Basel) 2019 Feb 6;11(2). Epub 2019 Feb 6.

Cell and Molecular Biology Department, QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia.

Glioblastomas are the most common and lethal neoplasms of the central nervous system. Neighbouring glioma cells maintain extreme degrees of genetic and phenotypic variation that form intratumoural heterogeneity. This genetic diversity allows the most adaptive tumour clones to develop treatment resistance, ultimately leading to disease recurrence. Read More

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http://dx.doi.org/10.3390/cancers11020190DOI Listing
February 2019
1 Read

Outcome of Bevacizumab Therapy in Patients with Recurrent Glioblastoma Treated with Angiotensin System Inhibitors.

Cancer Invest 2018 ;36(9-10):512-519

a Department of Radiation Biology, Department of Oncology , The Finsen Center , Rigshospitalet, Copenhagen , Denmark.

Purpose: Antihypertensive therapy may improve bevacizumab efficacy in cancer patients. We examined efficacy and toxicity of angiotensin system inhibitors (ASI) and other antihypertensive drugs in bevacizumab treated recurrent glioblastoma patients.

Methods: We retrospectively combined a national prescription registry with a clinical database with recurrent glioblastoma patients (n = 243). Read More

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http://dx.doi.org/10.1080/07357907.2018.1544639DOI Listing
February 2019
1 Read

Dural masses: meningiomas and their mimics.

Insights Imaging 2019 Feb 6;10(1):11. Epub 2019 Feb 6.

Department of Neuroradiology, St Bartholomew's and the Royal London Hospitals, Whitechapel, London, E1 1BB, UK.

Meningiomas are the most common dural tumour. They are regularly being seen as an incidental finding on brain imaging and treated conservatively. However, there are many other dural masses which mimic their appearances, including primary neoplastic processes, metastases, granulomatous diseases and infection. Read More

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http://dx.doi.org/10.1186/s13244-019-0697-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365311PMC
February 2019
9 Reads

Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.

J Ovarian Res 2019 Feb 4;12(1):13. Epub 2019 Feb 4.

Departamento de Ciências Fisiológicas, Universidade Federal do Maranhão, São Luís, Maranhão, Brazil.

Background: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360653PMC
February 2019
3 Reads

Intracranial Solitary Fibrous Tumors: a heterogeneous entity with an uncertain clinical behavior.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Neurosurgery department Strasbourg UniversityHospital, Strasbourg France.

Intracranial solitary fibrous tumors (ISFT) are rare mesenchymal neoplasms, originating in the meninges, characterized by very different biological and clinical behaviors. Benign histotypes such as hemangiopericytomas are now considered a cellular phenotypic variant of this heterogeneous group of rare spindle-cell tumors. Due to their rarity and resemblance to other more common brain tumors, ISFTs are often poorly recognized and remain a diagnostic challenge: in fact, ISFT might either have a benign/indolent clinical behavior or show biological aggressivity with local and distant recurrences after surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.142DOI Listing
February 2019

Atypical teratoid rhabdoid tumor mimicking type II neurofibromatosis: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14308

Department of Neurological Surgery, Children's Hospital, Zhejiang University School of Medicine, China.

Rationale: Brain magnetic resonance imaging (MRI) images of atypical teratoid rhabdoid tumor (ATRT) often present heterogeneous signals of various cells without remarkable features of the disease. We describe a unique case of atypical brain MRI images presenting as an type II neurofibromatosis and explore some diagnostic hints.

Patient Concerns: A 1-year-and-7-month-old boy admitted to our department with a 7-day history of drowsiness and 2-day history of emesis, and his presenting complaint was repeated vomit. Read More

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http://dx.doi.org/10.1097/MD.0000000000014308DOI Listing
February 2019
1 Read

Bobblehead-Doll Syndrome.

N Engl J Med 2019 Jan;380(5):e5

All India Institute of Medical Sciences, New Delhi, India

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http://dx.doi.org/10.1056/NEJMicm1808747DOI Listing
January 2019

Multicomponent non-pharmacological intervention to prevent delirium for hospitalised people with advanced cancer: study protocol for a phase II cluster randomised controlled trial.

BMJ Open 2019 Jan 28;9(1):e026177. Epub 2019 Jan 28.

IMPACCT - Improving Palliative, Aged and Chronic Care through Clinical Research and Translation, University of Technology Sydney, Sydney, New South Wales, Australia.

Introduction: Delirium is a significant medical complication for hospitalised patients. Up to one-third of delirium episodes are preventable in older inpatients through non-pharmacological strategies that support essential human needs, such as physical and cognitive activity, sleep, hydration, vision and hearing. We hypothesised that a multicomponent intervention similarly may decrease delirium incidence, and/or its duration and severity, in inpatients with advanced cancer. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026177DOI Listing
January 2019
2 Reads

Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra.

Eur Arch Otorhinolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, House Postal Number Q.04.5.300, Heidelberglaan 100, PO BOX 85500, 3584 CX, Utrecht, The Netherlands.

Objectives: Skeletal muscle mass (SMM) is most often assessed in cancer patients on abdominal computed tomography (CT) imaging at the level of the third lumbar vertebra (L3). Abdominal CT imaging is not routinely performed in head and neck cancer (HNC) patients. Recently, a novel method to assess SMM on a single transversal CT slice at the level of the third cervical vertebra (C3) was published. Read More

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http://dx.doi.org/10.1007/s00405-019-05307-wDOI Listing
January 2019

[Treatment of refractory aggressiveness by amygdalotomy and posteromedial hypothalamotomy by radiofrequency].

Rev Neurol 2019 Feb;68(3):91-98

Hospital General de Mexico OD, Cuauhtemoc, Mexico.

Introduction: Since, under certain circumstances, defensive or attacking behaviours display a pattern of motor dominance, as observed in subjects who participate in contact or fighting sports, aggressive behaviour was considered to have a dominant motor pattern. With the aim of preventing the functional problems reported with bilateral lesion procedures involving both the central nucleus of the amygdala and the posteromedial hypothalamus, the decision was made to combine them; thus, an amygdalotomy of the central nucleus of the amygdala and a posteromedial hypothalamotomy were to be performed simultaneously and unilaterally, on the basis of the motor dominance of the patient determined by means of the Edinburgh test.

Patients And Methods: This study describes the surgical experience in a series of nine patients diagnosed with refractory neuroaggressive syndrome. Read More

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February 2019
0.926 Impact Factor

Rudimentary Meningocele of the Scalp: A Pitfall in the Diagnosis of Vascular Neoplasms.

Case Rep Pathol 2018 26;2018:4847286. Epub 2018 Dec 26.

Consultant in Pathology, Neuberg Anand Reference Laboratories, Neuberg Diagnostics Pvt. Ltd., Thombra Arcade, Elamakkara Road, Kaloor, Cochin-682017, India.

We present a case of sequestrated meningocele in a 1-year-old girl, who presented with a 1x1cm occipital swelling since birth. CT brain revealed the soft tissue swelling to be extracranial. She underwent surgical excision of the specimen and the excised mass was sent for histopathological examination. Read More

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http://dx.doi.org/10.1155/2018/4847286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327270PMC
December 2018

Neonatal phototherapy and future risk of childhood cancer.

Int J Cancer 2019 Jan 26. Epub 2019 Jan 26.

Division of General Pediatrics, Department of Pediatrics, Sainte-Justine University Hospital Centre, University of Montreal, Montreal, QC, Canada.

We sought to determine if neonatal phototherapy is associated with a greater risk of childhood cancer. We conducted a retrospective cohort study of 786,998 infants born in hospitals of Quebec, Canada between 2006 and 2016, with 4,660,868 person-years of follow-up over an 11-year period. The exposures were neonatal phototherapy (32,314 or 4. Read More

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http://dx.doi.org/10.1002/ijc.32158DOI Listing
January 2019

A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma.

Acta Med Port 2018 Dec 28;31(12):777-783. Epub 2018 Dec 28.

Departamento de Neurocirurgia. Hospital de Braga. Braga. Portugal.

Primary central nervous system lymphoma remission after steroid treatment is a well-known phenomenon, but remission without any type of treatment is extremely rare. We present a rare case of spontaneous remission of a diffuse large B-cell lymphoma of the central nervous system as well as its subsequent reappearance in another location. The atypical presentation misled the neurosurgeons and neurologists, delaying diagnosis and treatment. Read More

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http://dx.doi.org/10.20344/amp.10198DOI Listing
December 2018
5 Reads

FGL2 promotes tumor progression in the CNS by suppressing CD103 dendritic cell differentiation.

Nat Commun 2019 01 25;10(1):448. Epub 2019 Jan 25.

Department of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.

Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and primary glioblastoma (GBM) cells. FGL2 knockout in tumor cells did not affect tumor-cell proliferation in vitro or tumor progression in immunodeficient mice but completely impaired GBM progression in immune-competent mice. Read More

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http://dx.doi.org/10.1038/s41467-018-08271-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347641PMC
January 2019
3 Reads
10.742 Impact Factor

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma.

Nat Commun 2019 01 25;10(1):442. Epub 2019 Jan 25.

Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA.

MicroRNA deregulation is a consistent feature of glioblastoma, yet the biological effect of each single gene is generally modest, and therapeutically negligible. Here we describe a module of microRNAs, constituted by miR-124, miR-128 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in gliomagenesis. Each one of these miRs targets several transcriptional regulators, including the oncogenic chromatin repressors EZH2, BMI1 and LSD1, which are functionally interdependent and involved in glioblastoma recurrence after therapeutic chemoradiation. Read More

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http://dx.doi.org/10.1038/s41467-019-08390-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347618PMC
January 2019
2 Reads

Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy.

Radiat Oncol 2019 Jan 25;14(1):16. Epub 2019 Jan 25.

Department of Radiation Oncology, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Fudan University, Shanghai, China.

Background: To evaluate the safety and efficacy of particle therapy (PT) using pencil beam scanning (PBS) technique for early stage non-small cell lung cancer (NSCLC).

Methods: From 08/2014 to 03/2018, 31 consecutive patients with sum of the longest diameters of primary tumor and hilar lymph node < 5 cm, N0-1, M0 NSCLC treated with PT were retrospectively analyzed. Gating/active breathing control techniques were used to control tumor motion in 20 and 7 patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1216-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347845PMC
January 2019
2 Reads

Neurosurgical therapy for Status Epilepticus in Oligoastrocytoma Patient: A case report.

World Neurosurg 2019 Jan 22. Epub 2019 Jan 22.

Epilepsy Clinic, National Institute of Neurology and Neurosurgery, Mexico City, Mexico.

Background: Super refractory epilepticus status (SRSE) is a life-threatening neurologic emergency defined as 'status epilepticus (SE) that continues 24 hours or more after the onset of anaesthesia, including those cases in which the SE recurs on the reduction or withdrawal of anaesthesia', which occur in 10-15% of SE patients and rarely has been resolved surgically.

Methods: A 20-year-old man with SRSE and a long history of left parieto-occipital oligoastrocytoma was admitted for convulsive SE that become SRSE and underwent lesionectomy guided by electrocorticography and neuro-navigation for local tumor recurrence. Histopathological diagnosis was oligoastrocytoma. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.027DOI Listing
January 2019
1 Read

Intraparenchymal schwannoma with calcification of the temporal lobe: Case report and literature review.

Medicine (Baltimore) 2019 Jan;98(4):e14263

Department of Neurosurgery.

Rationale: Intracranial schwannomas most frequently arise from the trigeminal nerve and the vestibular nerve. Schwannomas within the cerebral parenchyma are exceedingly rare. Additionally, calcification is an uncommon histopathological and radiological characteristic in schwannomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000014263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358367PMC
January 2019
6 Reads

Brain metastasis in pancreatic cancer: Two case reports.

Medicine (Baltimore) 2019 Jan;98(4):e14227

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo.

Rationale: Brain metastases are extremely rare for patients with pancreatic adenocarcinoma due to the poor prognoses. In the present study, we reported 2 cases of pancreatic adenocarcinoma with brain metastases.

Patient Concerns: The 1st patient was diagnosed asymptomatic brain metastasis by a follow-up brain magnetic resonance imaging (MRI) due to a medical history of subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1097/MD.0000000000014227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358345PMC
January 2019

Significant response of low-dose apatinib monotherapy in brain metastases of triple-negative breast cancer: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14182

Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan, P. R. China.

Rationale: The potential efficacy of apatinib in patients with advanced triple-negative breast cancer (TNBC) has been observed in a previous phase II clinical study. However, there is no study to evaluate its efficacy and safety in TNBC patients with brain metastasis (BM). Here we report one case that apatinib exhibited excellent antitumor effects in a breast cancer patient with brain metastasis, with no serious treatment-associated with adverse event. Read More

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http://dx.doi.org/10.1097/MD.0000000000014182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358397PMC
January 2019
1 Read

[The pathological characteristics and outcomes of 40 surgically treated stage M1b non-small cell lung cancer patients].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):63-67

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Clinical evidences of surgically treated stage M1b non-small cell lung cancer (NSCLC) patients were limited. This study aimed to summarize the clinical data of these patients to explore the prognostic factors of this population. From January 1999 to December 2012, the clinical data of 40 stage M1b NSCLC patients, including 24 males and 16 females, who underwent surgery were collected by Cancer Hospital, Chinese Academy of Medical Sciences. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.011DOI Listing
January 2019
1 Read

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
6 Reads

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature.

World J Surg Oncol 2019 Jan 19;17(1):22. Epub 2019 Jan 19.

Division of Neurological Surgery, Department of Surgery, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

Background: Congenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis. Read More

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http://dx.doi.org/10.1186/s12957-019-1564-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339688PMC
January 2019
3 Reads
1.200 Impact Factor

Intramedullary spinal cord metastases: an institutional review of survival and outcomes.

J Neurooncol 2019 Jan 17. Epub 2019 Jan 17.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA.

Introduction: Intramedullary spinal cord metastases (ISCMs) are rare lesions affecting the spinal cord in patients with disseminated malignancy. Today, due to increased survival, these lesions are more frequently diagnosed. Literature on survival and neurologic outcomes is sparse. Read More

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http://dx.doi.org/10.1007/s11060-019-03105-2DOI Listing
January 2019
1 Read

Central nervous system tumor registration in the Swedish Cancer Register and Inpatient Register between 1990 and 2014.

Clin Epidemiol 2019 4;11:81-92. Epub 2019 Jan 4.

Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,

Background: The Swedish Cancer Register (SCR) is characterized by excellent quality and completeness overall, but the quality of the reporting may vary according to tumor site and age, and may change over time. The aim of the current study was to investigate the completeness of the reporting of central nervous system (CNS) tumor cases to the SCR.

Materials And Methods: Individuals hospitalized for a CNS tumor between 1990 and 2014 were identified using the Inpatient Register; the proportion of identified cases that did not have any cancer diagnosis reported to the SCR was subsequently assessed. Read More

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https://www.dovepress.com/central-nervous-system-tumor-regis
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http://dx.doi.org/10.2147/CLEP.S177683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324922PMC
January 2019
6 Reads

Brain atlas for assessing the impact of tumor location on perioperative quality of life in patients with high-grade glioma: A prospective population-based cohort study.

Neuroimage Clin 2019 Jan 8:101658. Epub 2019 Jan 8.

Department of Neurosurgery, St Olavs University Hospital, 7006 Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway.

Background: Tumor location is important for surgical decision making. Particular attention is paid to regions that contain sensorimotor and language functions, but it is unknown if these are the most important regions from the patients' perspective.

Objective: To develop an atlas for depicting and assessing the potential importance of tumor location for perioperative health-related quality of life (HRQoL) in patients with newly diagnosed high-grade glioma. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101658DOI Listing
January 2019

Effect of pemetrexed on brain metastases from nonsmall cell lung cancer with wild-type and unknown EGFR status.

Authors:
Xiaoqing Yu Yun Fan

Medicine (Baltimore) 2019 Jan;98(3):e14110

Technology on Thoracic Oncology (Esophagus, Lung), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.

We aimed to evaluate the effectiveness of pemetrexed-based chemotherapy in wild-type nonsmall-cell lung cancer (NSCLC) patients with brain metastases (BM). Brain metastases are a common cause of mortality in NSCLC patients. For epidermal growth factor receptor (EGFR) wild-type patients, therapeutic options for BM are even limited. Read More

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http://dx.doi.org/10.1097/MD.0000000000014110DOI Listing
January 2019
1 Read

Solitary colonic metastasis from primary lung adenocarcinoma first presenting as intestinal obstruction: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14063

Department of Surgery.

Rationale: The brain, liver, adrenal glands, and bone are the most common sites of metastatic disease in patients with lung cancer. Symptomatic gastrointestinal metastases are rare. In the present report, we describe a rare case of a patient with intestinal obstruction due to solitary colonic metastasis from primary lung adenocarcinoma, wherein the intestinal obstruction was the first symptom of lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014063DOI Listing
January 2019
1 Read

Brain metastasis from ovarian clear cell carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14020

Department of Oncology, Xiang Ya Hospital, Central South University, China.

Rationale: Epithelial ovarian carcinoma (EOC) is the most common type of ovarian carcinoma, and the leading cause of female genital tract cancer-related deaths. However, brain metastasis (BM) of EOC is rare, with an incidence of only 1% to 2%. Ovarian clear cell carcinoma (OCCC), accounting for 5% to 25% of all EOC cases, has a poor prognosis compared with other epithelial cell type carcinomas. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0002
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000014020DOI Listing
January 2019
4 Reads

Steering CAR T Cells into Solid Tumors.

N Engl J Med 2019 01;380(3):289-291

From the Sir William Dunn School of Pathology (M.H.B.) and the Kennedy Institute of Rheumatology (M.L.D.), University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1056/NEJMcibr1811991DOI Listing
January 2019

Cerebral Amyloid Angiopathy Related İnflammation Presenting As Steroid Responsive Brain Mass.

Turk Neurosurg 2018 Sep 11. Epub 2018 Sep 11.

Yeditepe University Hospital.

Cerebral amyloid angiopathy (CAA) is a common but often asymptomatic disease, characterized by the deposition of amyloid proteins within brain parenchyma and leptomeningeal-cortical vessels. It can occur as a sporadic disorder or accompany Alzheimer disease (AD). The usual presantation of CAA is spontenous lobar hemorrage, Unlike CAA, cerebral amyloid angiopathy-related inflammation (CAA-ri),a subtype of CAA, can show different presentations and responds to steroid (or immunsupressive) treatment. Read More

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http://www.turkishneurosurgery.org.tr/summary_en_doi.php3?do
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http://dx.doi.org/10.5137/1019-5149.JTN.22592-18.3DOI Listing
September 2018
6 Reads

Albumin binding and anticancer effect of magnesium oxide nanoparticles.

Int J Nanomedicine 2019 27;14:257-270. Epub 2018 Dec 27.

Department of Nanotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran,

Background: Recently, nanomaterials have moved into biological and medicinal implementations like cancer therapy. Therefore, before clinical trials, their binding to plasma proteins like human serum albumin (HSA) and their cytotoxic effects against normal and cancer cell lines should be addressed.

Methods: Herein, the interaction of magnesium oxide nanoparticles (MgO NPs) with HSA was studied by means of fluorescence spectroscopy, circular dichroism (CD) spectroscopy, and docking studies. Read More

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https://www.dovepress.com/albumin-binding-and-anticancer-eff
Publisher Site
http://dx.doi.org/10.2147/IJN.S186428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312066PMC
February 2019
7 Reads

Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.

Nat Commun 2019 01 14;10(1):201. Epub 2019 Jan 14.

Department of Cancer Cell Biology, Tianjin's Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, 300060, Tianjin, China.

Under hypoxia, most of glucose is converted to secretory lactate, which leads to the overuse of glutamine-carbon. However, under such a condition how glutamine nitrogen is disposed to avoid over-accumulating ammonia remains to be determined. Here we identify a metabolic flux of glutamine to secretory dihydroorotate, which is indispensable to glutamine-carbon metabolism under hypoxia. Read More

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http://dx.doi.org/10.1038/s41467-018-08033-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331631PMC
January 2019

[Intracranial involvement in newly diagnosed multiple myeloma with TP53 deletion: Two case reports].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1272-1275

Department of Hematology, Fujian Provincial Hospital; Provincial Clinical Medicine College, Fujian Medical University, Fuzhou 350001, China.

We report two rare cases of multiple myeloma (MM) with dural intracranial disease and TP53 deletion. The two patients presented with skull lytic lesion and dural involvement of myeloma. The association between intracranial involvement in MM and TP53 deletion has not been determined. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.11.018DOI Listing
November 2018
1 Read

[An artificial neural network model for glioma grading using image information].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1315-1322

Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008; Postdoctoral Research Workstation of Clinical Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To explore the feasibility and efficacy of artificial neural network for differentiating high-grade glioma and low-grade glioma using image information.
 Methods: A total of 130 glioma patients with confirmed pathological diagnosis were selected retrospectively from 2012 to 2017. Forty one imaging features were extracted from each subjects based on 2-dimension magnetic resonance T1 weighted imaging with contrast-enhancement. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.006DOI Listing
December 2018

[Brain tumors in children: about 136 cases].

Pan Afr Med J 2018 24;30:291. Epub 2018 Aug 24.

Service d'Anatomie Pathologique, CHU Mohammed VI, Hôpital Arrazi, Marrakech, Maroc.

Brain tumors are the most diagnosed solid tumors in children under the age of 15 years worldwide. However, the epidemiological and anatomopathological profile of these tumors has been poorly described in African and, particularly, in Moroccan literature. This study highlights the epidemiological and anatomopathological peculiarities of primary brain tumors in children living in the region of Marrakech (south Morocco). Read More

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http://www.panafrican-med-journal.com/content/article/30/291
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.291.13208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317398PMC
January 2019
4 Reads

Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis.

J Pathol Transl Med 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon, Korea.

Background: Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate the diagnostic value of cytology in frozen diagnoses of CNS neoplasms. Read More

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http://dx.doi.org/10.4132/jptm.2018.11.10DOI Listing
January 2019
2 Reads

Transnasal endoscopic surgery in selected nasal-ethmoidal cancer with suspected brain invasion: Indications, technique, and outcomes.

Head Neck 2019 Jan 12. Epub 2019 Jan 12.

Unit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Background: In nasal-ethmoidal malignancies, brain involvement is associated with dismal prognosis.

Method: Patients undergoing endoscopic resection with transnasal craniectomy and subpial dissection (ERTC-SD) for brain-invading nasal-ethmoidal cancer between 2008 and 2016 were included. Complications were analyzed in all patients, whereas oncological outcomes only in patients with pathological brain invasion. Read More

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http://doi.wiley.com/10.1002/hed.25621
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http://dx.doi.org/10.1002/hed.25621DOI Listing
January 2019
7 Reads

Dynamic [18F]FET-PET/MRI using standard MRI-based attenuation correction methods.

Eur Radiol 2019 Jan 11. Epub 2019 Jan 11.

Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Aim: To assess if tumour grading based on dynamic [18F]FET positron emission tomography/magnetic resonance imaging (PET/MRI) studies is affected by different MRI-based attenuation correction (AC) methods.

Methods: Twenty-four patients with suspected brain tumours underwent dynamic [18F]FET-PET/MRI examinations and subsequent low-dose computed tomography (CT) scans of the head. The dynamic PET data was reconstructed using the following AC methods: standard Dixon-based AC and ultra-short echo time MRI-based AC (MR-AC) and a model-based AC approach. Read More

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http://link.springer.com/10.1007/s00330-018-5942-9
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http://dx.doi.org/10.1007/s00330-018-5942-9DOI Listing
January 2019
3 Reads

Papillary glioblastoma exhibiting a neuroradiological cyst with a mural nodule: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14102

Division of Human Pathology, Department of Pathology and Microbiology.

Rationale: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901110-0007
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000014102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336597PMC
January 2019
2 Reads

Resting-State Functional Connectivity of the Middle Frontal Gyrus Can Predict Language Lateralization in Patients with Brain Tumors.

AJNR Am J Neuroradiol 2019 Feb 10;40(2):319-325. Epub 2019 Jan 10.

Departments of Radiology (M.E.L., M.J., K.P., V.H., A.I.H., B.V.)

Background And Purpose: A recent study using task-based fMRI demonstrated that the middle frontal gyrus is comparable with Broca's area in its ability to determine language laterality using a measure of verbal fluency. This study investigated whether the middle frontal gyrus can be used as an indicator for language-hemispheric dominance in patients with brain tumors using task-free resting-state fMRI. We hypothesized that no significant difference in language lateralization would occur between the middle frontal gyrus and Broca area and that the middle frontal gyrus can serve as a simple and reliable means of measuring language laterality. Read More

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http://www.ajnr.org/lookup/doi/10.3174/ajnr.A5932
Publisher Site
http://dx.doi.org/10.3174/ajnr.A5932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375738PMC
February 2019
6 Reads

Recurrent ischaemic cerebrovascular events as presenting manifestations of myeloproliferative neoplasms.

Eur J Neurol 2019 Jan 10. Epub 2019 Jan 10.

Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.

Background And Purpose: Myeloproliferative neoplasms (MPNs) - polycythemia vera, essential thrombocythemia and primary myelofibrosis - are associated with increased risk for ischaemic cerebrovascular events (ICVEs). Due to their low prevalence, MPNs often remain undiagnosed as the cause of ICVEs.

Methods: Case records at the University of Tübingen between 2014 and 2017 were screened to identify patients with MPN-related ICVEs. Read More

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http://doi.wiley.com/10.1111/ene.13907
Publisher Site
http://dx.doi.org/10.1111/ene.13907DOI Listing
January 2019
9 Reads

Amplification-free and direct fluorometric determination of telomerase activity in cell lysates using chimeric DNA-templated silver nanoclusters.

Mikrochim Acta 2019 01 9;186(2):81. Epub 2019 Jan 9.

School of Pharmacy, Faculty of Science, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.

A fluorogenic probe has been developed for determination of telomerase activity using chimeric DNA-templated silver nanoclusters (AgNCs). The formation of AgNCs was investigated before (route A) and after (route B) telomerase elongation reaction. Both routes caused selective quenching of the yellow emission of the AgNCs (best measured at excitation/emission wavelength of 470/557 nm) in telomerase-positive samples. Read More

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http://dx.doi.org/10.1007/s00604-018-3194-7DOI Listing
January 2019
3.741 Impact Factor

Progress in the fight against brain cancer.

Authors:

Nature 2019 01;565(7738):134

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http://dx.doi.org/10.1038/d41586-019-00077-1DOI Listing
January 2019
1 Read

Light can treat inoperable brain tumours.

Nature 2019 01;565(7738):161

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http://dx.doi.org/10.1038/d41586-019-00020-4DOI Listing
January 2019
1 Read

A miniature multi-contrast microscope for functional imaging in freely behaving animals.

Nat Commun 2019 01 9;10(1):99. Epub 2019 Jan 9.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, and dysregulated in neuropathologies such as brain tumors. Interrogating these phenomena in freely behaving animals requires a portable microscope with multiple optical contrast mechanisms. Therefore, we developed a miniaturized microscope with: a fluorescence (FL) channel for imaging neural activity (e. Read More

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http://dx.doi.org/10.1038/s41467-018-07926-zDOI Listing
January 2019
1 Read

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
2 Reads