187,066 results match your criteria Neoplasms Brain


[Ileum and brain, unusual metastatic sites for a thymoma].

Rev Mal Respir 2020 May 29. Epub 2020 May 29.

Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, AP-HP, Le Kremlin-Bicêtre, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France; Inserm UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France.

Introduction: Thymomas are epithelial neoplasms of thymic origin, preferentially localized in the anterior mediastinum. Recurrences after surgery are uncommon and usually occur in the intrathoracic area. The occurrence of extra-thoracic metastases is an unusual phenomenon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.rmr.2020.04.008DOI Listing

Lymphoepithelial Carcinoma of Salivary Gland EBV-association in Endemic versus Non-Endemic Patients: A Report of 16 Cases.

Head Neck Pathol 2020 May 27. Epub 2020 May 27.

Southern California Permanente Medical Group, Department of Pathology, 5601 De Soto Avenue, Woodland Hills, CA, 91365, USA.

Lymphoepithelial carcinoma of salivary glands (LECSG) are rare neoplasms, reported in endemic populations (southeastern Chinese) with a strong Epstein-Barr virus (EBV) association. A retrospective series comparing EBV status within an ethnically diverse population (endemic vs. non-endemic patients) has not been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12105-020-01172-wDOI Listing

Heme Oxygenase-1 in Central Nervous System Malignancies.

J Clin Med 2020 May 21;9(5). Epub 2020 May 21.

Department of Drug Science, Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

Central nervous system tumors are the most common pediatric solid tumors and account for 20%-25% of all childhood malignancies. Several lines of evidence suggest that brain tumors show altered redox homeostasis that triggers the activation of various survival pathways, leading to disease progression and chemoresistance. Among these pathways, heme oxygenase-1 (HO-1) plays an important role. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9051562DOI Listing

Unusual cause of seizure in a child: Intracranial calcified metastasis of osteosarcoma.

Indian J Cancer 2020 Apr-Jun;57(2):209-211

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, India.

Intracranial parenchymal calcification has both benign and malignant etiologies. Calcifications by malignant etiologies are comparatively rare. Malignant calcification has numerous causes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijc.IJC_796_18DOI Listing

Head and neck cancer survivorship from the patient perspective.

Head Neck 2020 May 23. Epub 2020 May 23.

Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.

Background: Survivorship is a critical part of head and neck cancer (HNC) care. In order to design better processes, we assessed care provided to long-term HNC survivors and their priorities for ongoing care.

Methods: A survey was provided to HNC survivors at clinic appointments, including our HNC survivorship clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.26265DOI Listing

Clival Chordoma in an Adolescent: A Perspective from Primary Care.

Korean J Fam Med 2020 May 22. Epub 2020 May 22.

Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Selangor, Malaysia.

Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache and blurring of vision, as well as a 6-month history of left-sided facial and body numbness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4082/kjfm.19.0004DOI Listing

Diffuse pneumonitis from coronavirus HKU1 on checkpoint inhibitor therapy.

J Immunother Cancer 2020 05;8(1)

Oncology, Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA.

Background: Immune checkpoint inhibitors (ICIs) can produce specific immune-related adverse events including pneumonitis. The impact of ICI therapy on the severity of acute coronavirus infection symptomatology warrants further exploration.

Case Presentation: We report a 65-year-old man diagnosed with stage IV melanoma who developed pulmonary and brain metastases and was treated with bilateral craniotomies followed by combined nivolumab and ipilimumab immunotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jitc-2020-000898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246106PMC

Second cancer risk after primary cancer treatment with three-dimensional conformal, intensity-modulated, or proton beam radiation therapy.

Cancer 2020 May 19. Epub 2020 May 19.

Department of Radiation Oncology, Stanford University, Stanford, California, USA.

Background: The comparative risks of a second cancer diagnosis are uncertain after primary cancer treatment with 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), or proton beam radiotherapy (PBRT).

Methods: Pediatric and adult patients with a first cancer diagnosis between 2004 and 2015 who received 3DCRT, IMRT, or PBRT were identified in the National Cancer Database from 9 tumor types: head and neck, gastrointestinal, gynecologic, lymphoma, lung, prostate, breast, bone/soft tissue, and brain/central nervous system. The diagnosis of second cancer was modeled using multivariable logistic regression adjusting for age, follow-up duration, radiotherapy (RT) dose, chemotherapy, sociodemographic variables, and other factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.32938DOI Listing

Location and Diameter of Intracranial Meningioma as Predictors of Peritumoral Brain Oedema and Mass Effect.

J Med Imaging Radiat Sci 2020 May 15. Epub 2020 May 15.

Neuroradiology and MRI Section, National Hospital of Sri Lanka, Colombo, Sri Lanka.

Introduction: The presence of peritumoral oedema or mass effect with intracranial meningiomas is associated with poor clinical outcomes. This study aimed to investigate magnetic resonance (MR) morphologic features of meningioma, which can predict peritumoral oedema and mass effect.

Methods: Data of 100 consecutive patients diagnosed with meningioma on MRI brain at the neurosurgical MRI unit, National Hospital of Sri Lanka, reported by a Consultant Radiologist were analysed in a retrospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmir.2020.04.004DOI Listing

Pleuropulmonary blastoma-like peritoneal sarcoma: a newly described malignancy associated with biallelic DICER1 pathogenic variation.

Mod Pathol 2020 May 15. Epub 2020 May 15.

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, MN, USA.

Since the original description of pathogenic germline DICER1 variation underlying pleuropulmonary blastoma (PPB), the spectrum of extrapulmonary neoplasms known to be associated with DICER1 has continued to expand and now includes tumors of the ovary, thyroid, kidney, eye, and brain among other sites. This report documents our experience with another manifestation: a primitive sarcoma that resembles PPB and DICER1-associated sarcoma of the kidney. These tumors are distinguished by their unusual location in the peritoneal cavity, associated with visceral and/or parietal mesothelium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-020-0558-4DOI Listing

Meningioma in a patient with Werner syndrome.

Neurol India 2020 Mar-Apr;68(2):483-486

Department of Neurosurgery and Gamma Knife, P D Hinduja Hospital and MRC, Mahim, Mumbai, Maharashtra, India.

Werner syndrome (WS), also known as adult progeria, is extremely rare, with about 1300 known cases in the world, with over 1000 of these in Japan. It occurs due to loss of function mutations in the WRN gene located on chromosome 8p12. WS is characterized by premature aging and increased risk of neoplasms, with meningiomas being the commonest intracranial tumor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0028-3886.284350DOI Listing

[Multicystic transformation of the post-radiation necrosis zone of the brain. A case report and literature review].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(2):72-82

Burdenko Neurosurgical Center, Moscow, Russia.

Post-radiation cyst of the brain is a rare complication that often arises many years after irradiation for head and neck neoplasms. The majority of the articles devoted to this problem are small samples or case reports. Nevertheless, the overall number of these patients is steadily increasing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/neiro20208402172DOI Listing
January 2020

How we treat patients with brain tumour during the COVID-19 pandemic.

ESMO Open 2020 05;4(Suppl 2)

Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria

The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. This is particularly true in the field of neuro-oncology, where the perceived benefit of therapeutic interventions is often low, although this notion is partially incorrect. We acknowledge that the recommendations for care of patients with cancer have become a moving target and that all recommendations are subject to modification based on national and institutional regulations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/esmoopen-2020-000789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234866PMC

The Day My Gut Feeling Led Me Astray.

Authors:
Vanita Noronha

N Engl J Med 2020 May;382(20):1880-1881

From the Department of Medical Oncology, Tata Memorial Hospital, Parel, and the Homi Bhabha National Institute - both in Mumbai, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp1917572DOI Listing

Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model.

Cancer Imaging 2020 May 12;20(1):35. Epub 2020 May 12.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Anti-angiogenic treatment of glioblastoma (GBM) complicates radiologic monitoring. We evaluated magnetic resonance elastography (MRE) as an imaging tool for monitoring the efficacy of anti-VEGF treatment of GBM.

Methods: Longitudinal studies were performed in an orthotopic GBM xenograft mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40644-020-00314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218549PMC

CD8 T-cell encephalitis mimicking PRES in AIDS: a case report.

BMC Neurol 2020 May 12;20(1):179. Epub 2020 May 12.

Department of Neurology, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Diverse mechanisms including infections, autoimmune inflammatory reactions, neoplasms, and degeneration are involved in the central nervous system in cases of acquired immune deficiency syndrome. In such cases, it is difficult to determine the precise pathogenesis by radiological examination and laboratory testing.

Case Presentation: We report a 37-year-old Japanese woman who had untreated hypertension and gender identity disorder and had been taking testosterone injections since she was 19 years old. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12883-020-01756-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216593PMC

Metastatic non-functional paraganglioma to the lung.

J Cardiothorac Surg 2020 May 11;15(1):82. Epub 2020 May 11.

Department of Thoracic Oncology, King Hussein Cancer Center, Amman, Jordan.

Introduction: Paragangliomas are rare endocrine tumors that arise from the extra-adrenal autonomic paraganglia and sympathetic paragangliomas usually secret catecholamines and are located in the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis. In contrast, most parasympathetic paragangliomas are nonfunctional and located along the glossopharyngeal and vagal nerves in the neck and at the base of the skull. Such neoplasms, although rare, are clinically important because they may recur after surgical resection and 10% of them give rise to metastases causing death with the lymphatic nodes, bones, liver, and lungs being the most common locations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13019-020-01113-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216671PMC

[Heterogeneity in PD-L1 expression on infiltrating immune cells between the primary and metastatic breast cancers].

Zhonghua Bing Li Xue Za Zhi 2020 May;49(5):430-434

Department of Pathology, the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China.

To investigate the expression difference in PD-L1 on mesenchymal infiltrating immune cells between the primary and metastatic breast cancers, and to explore its relationship with clinicopathological parameters. All cases of primary breast cancer and their matched metastases diagnosed at the Fourth Hospital of Hebei Medical University between January 2010 and December 2018 were included. Immunohistochemistry (IHC) was used to detect the expression of PD-L1 (SP142) in interstitial infiltrating immune cells, and the expression of ER, PR, HER2 and Ki-67 in primary and matched metastases was detected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112151-20200225-00137DOI Listing

Prostate-specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain.

J Cell Mol Med 2020 May 11. Epub 2020 May 11.

Translational Cancer Medicine Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Glioblastomas and brain metastases (BM) of solid tumours are the most common central nervous system neoplasms associated with very unfavourable prognosis. In this study, we report the association of prostate-specific membrane antigen (PSMA) with various clinical parameters in a large cohort of primary and secondary brain tumours. A tissue microarray containing 371 cases of ascending grades of gliomas pertaining to astrocytic origin and samples of 52 cases of primary lung carcinomas with matching BM with follow-up time accounting to 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.15350DOI Listing

The prognostic value of prognostic nutritional index (PNI) and neutrophil to lymphocyte ratio (NLR) for advanced non-small cell lung cancer treated with platinum-based chemotherapeutics.

Ann Palliat Med 2020 Apr 21. Epub 2020 Apr 21.

Department of Oncology, Cancer Rehabilitation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Background: The present study aimed to investigate the relationship between prognostic nutritional index (PNI) and peripheral blood neutrophil to lymphocyte ratio (NLR), and the prognosis of patients with advanced non-small cell lung cancer (NSCLC) treated with platinum-based therapeutics.

Methods: The data of 99 advanced NSCLC patients treated with platinum chemotherapeutics between January 2011 and June 2019 were retrospectively analyzed. The association between PNI and NLR and the clinicopathological characteristics of the patients was examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm.2020.04.31DOI Listing

Long lasting trigeminal neuropathy, limbic encephalitis and abdominal ganglionitis without primary cancer: An atypical case of Hu-antibody syndrome.

Clin Neurol Neurosurg 2020 Apr 18;194:105849. Epub 2020 Apr 18.

Neurology Department, Gent University Hospital, Gent, Belgium; Neurology Department, St Lucas General Hospital Gent, Belgium.

Objectives: Anti-Hu antibodies (Hu-Abs) are the most frequent onconeural antibodies associated with paraneoplastic neurologic syndromes (PNS). PNS include a variety of neurological syndromes, affecting less than 1/10,000 patients with cancer. In the majority of cases, PNS will manifest before the malignancy is diagnosed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clineuro.2020.105849DOI Listing

Comparative efficacy of antiangiogenic treatment for newly diagnosed glioblastoma: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2020 May;99(19):e20011

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing.

Background: Glioblastoma is the most common malignant primary brain tumor which has highly expressed vascular endothelial growth factor. To date, various antiangiogenic drugs have been investigated in clinical trials but with no overall conclusion, especially for newly diagnosed glioblastoma (nGBM). In this study, Bayesian network meta-analysis will be used to conduct a comprehensive analysis of the results of different clinical trials, and assess the efficacy of different antiangiogenic drugs on nGBM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020011DOI Listing

Orofacial pain secondary to acoustic neuroma-A case report.

Spec Care Dentist 2020 May 8;40(3):303-307. Epub 2020 May 8.

Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Aim: The present study aimed to report a case of orofacial pain secondary to acoustic neuroma (AN).

Methods And Results: A 66-year-old female presented with unilateral facial pain and odontalgia. The pain was described as throbbing, dull, and constant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/scd.12461DOI Listing

Human T-cell Lymphotropic Virus Type I Associated with Amyotrophic Lateral Sclerosis Syndrome: Immunopathological Aspects and Treatment Options.

Cureus 2020 Apr 3;12(4):e7531. Epub 2020 Apr 3.

Internal Medicine, Clínica de Occidente, Jamundi, COL.

Human T-cell lymphotropic virus type I (HTLV-I) is a retrovirus related to infectious myelopathies, neoplasms, lymphomas, leukemias, and amyotrophic lateral sclerosis (ALS). It is acquired through sexual transmission, transfusion of blood products, and breastfeeding. The increased expression of human endogenous retrovirus K (HERV-K) in the brain tissue of patients with ALS has been demonstrated, a finding that supports the relationship between the virus and this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198105PMC

Outcomes in the management of high-risk gestational trophoblastic neoplasia in trophoblastic disease centers in South America.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: South America has a higher incidence of gestational trophoblastic disease than North America or Europe, but whether this impacts chemotherapy outcomes is unclear. The purpose of this study was to evaluate outcomes among women with high-risk gestational trophoblastic neoplasia (GTN) treated at trophoblastic disease centers in developing South American countries.

Methods: This retrospective cohort study included patients with high-risk GTN treated in three trophoblastic disease centers in South America (Botucatu and Rio de Janeiro, Brazil, and Buenos Aires, Argentina) from January 1990 to December 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/ijgc-2020-001237DOI Listing

Preliminary study of central nervous system tumors' prevalence and incidence in Isfahan Province Iran.

J Egypt Natl Canc Inst 2020 Mar 19;32(1):14. Epub 2020 Mar 19.

Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Metastatic or primary cancers of the central nervous system are a dissimilar cluster of neoplasms with different consequences and management plans. The aim of this study was to obtain prevalence and incidence of brain and other nervous system tumors.

Results: In all, 423 females and 620 males were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s43046-020-00022-8DOI Listing

Feasibility of performance-based functional assessment in brain tumour survivors.

Eur J Cancer Care (Engl) 2020 May 5:e13238. Epub 2020 May 5.

Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.

Introduction: Rehabilitation and exercise interventions are beneficial for the physical and psychological health of cancer survivors. Current clinic-based performance status measures do not accurately capture the survivor's functioning, or rehabilitation and exercise needs. Our primary objective was to explore the feasibility of performing a performance-based functional assessment with brain tumour survivors as a means to inform needs for rehabilitation and exercise. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ecc.13238DOI Listing

The intracranial vasculature of canines represents a model for neurovascular ischemia and training residents and fellows in endovascular neurosurgery.

Neuroradiol J 2020 May 5:1971400920920787. Epub 2020 May 5.

New Era Stroke Care and Research Institute, The PLA Rocket Force General Hospital, Beijing, China.

Background: We describe use of a canine model to evaluate physiological effects and neuroprotective strategies in the setting of cerebral ischemia and endovascular neurosurgery training.

Methods: We performed transfemoral digital subtraction cerebral and cervical angiography on eight anesthetized dogs. Angiographic images of cerebral arteries were obtained following cannulation of the femoral artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1971400920920787DOI Listing

The Role of Predictive Model Based on Quantitative Basic Magnetic Resonance Imaging in Differentiating Medulloblastoma from Ependymoma.

Anticancer Res 2020 May;40(5):2975-2980

School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background/aim: Even though advanced magnetic resonance imaging (MRI) can effectively differentiate between medulloblastoma and ependymoma, it is not readily available throughout the world. This study aimed to investigate the role of simple quantified basic MRI sequences in the differentiation between medulloblastoma and ependymoma in children.

Patients And Methods: The institutional review board approved this prospective study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14277DOI Listing

Evaluation of Five Survival Scores in a Cohort of Elderly Patients With Cerebral Metastasis from Non-small Cell Lung Cancer.

Anticancer Res 2020 May;40(5):2847-2851

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Survival scores are important for treatment personalisation. A score for older patients with cerebral metastasis from non-small cell lung cancer (NSCLC) was generated.

Patients And Methods: Dose-fractionation of whole-brain irradiation, age, gender, general condition, histology, count of cerebral lesions, extra-cerebral metastatic spread and time between NSCLC-diagnosis and whole-brain irradiation were analysed for survival in 285 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14259DOI Listing

Extra-cerebral Metastasis - An Independent Predictor of Survival in Older Patients With Brain Metastases Receiving a Local Therapy Plus Whole-Brain Radiotherapy (WBRT).

Anticancer Res 2020 May;40(5):2841-2845

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Although omitting whole-brain radiotherapy (WBRT) during the treatment of few brain metastases more popular, many patients receive local therapies plus WBRT. WBRT may be less reasonable for patients with poor overall survival (OS), particularly if they are older. This study aimed to identify predictors of OS in these patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14258DOI Listing

Five Genes Associated With Survival in Patients With Lower-grade Gliomas Were Identified by Information-theoretical Analysis.

Anticancer Res 2020 May;40(5):2777-2785

Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.

Background/aim: Understanding of the molecular events associated with progression and survival differences in patients with lower-grade gliomas (LGGs) is still unclear. The comparison of findings across studies using different datasets and methods is essential for a new molecular-based classification system. The aim of the study was to identify biomarkers for prognostic classification of patients with LGGs, and furthermore to lay a foundation for future development of targeted therapies for LGGs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14250DOI Listing

Glioblastoma Factors Increase the Migration of Human Brain Endothelial Cells by Increasing MMP-9/CXCR4 Levels.

Anticancer Res 2020 May;40(5):2725-2737

Department of Cellular and Molecular Biology, Institute of Biology, Fluminense Federal University, Niteroi, Brazil

Background/aim: Glioblastoma (GB) is the most aggressive type of tumor in the central nervous system and is characterized by resistance to therapy and abundant vasculature. Tumor vessels contribute to the growth of GB, and the tumor microenvironment is thought to influence tumor vessels. We evaluated the molecular communication between human GB cells and human brain microvascular endothelial cells (HBMEC) in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21873/anticanres.14244DOI Listing

How accurately can multiparametric magnetic resonance imaging measure the tumour volume of a prostate cancer? Results of a systematic review.

J Med Imaging Radiat Oncol 2020 May 4. Epub 2020 May 4.

Brain-Behaviour Research Group, University of New England, Armidale, New South Wales, Australia.

The tumour volume of a cancer within the prostate gland is commonly measured with multiparametric MRI. The measurement has a role in many clinical scenarios including focal therapy, but the accuracy of it has never been systematically reviewed. We included articles if they compared tumour volume measurements obtained by mpMRI with a reference volume measurement obtained after radical prostatectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1754-9485.13035DOI Listing

Synchronous high-grade bladder carcinoma associated with chronic lymphocytic leukemia: A rare entity in Indian literature.

J Cancer Res Ther 2020 Jan-Mar;16(1):180-182

Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) is one of the common lymphoproliferative disorders with an increased risk of developing subsequent neoplasms of epithelial and mesenchymal origin. The decreased immunity and B-cell dysfunction in CLL probably accounts for this emergence of secondary malignancy. Breast, brain, skin and prostate tumors have been reported as usual coincident malignancies of CLL, while in occasional cases CLL may occur with malignancies of other solid organs, such as skin, lung, heart, and prostate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/jcrt.JCRT_642_16DOI Listing

Approaches to measure paediatric chemotherapy-induced peripheral neurotoxicity: a systematic review.

Lancet Haematol 2020 May;7(5):e408-e417

Brain and Mind Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

In children who receive neurotoxic chemotherapy, peripheral neurotoxicity occurs frequently, necessitates dose reduction or treatment cessation, and affects function and long-term quality of life. No treatments exist for peripheral neurotoxicity and few assessment measures are specific to children. We did a systematic review to analyse the published literature concerning the evaluation of assessment measures for paediatric chemotherapy-induced peripheral neurotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3026(20)30064-8DOI Listing

Fetal brain, head, and neck tumors: Prenatal imaging and management.

Prenat Diagn 2020 Apr 30. Epub 2020 Apr 30.

The Center for fetal diagnosis and treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Fetal tumors represent an infrequent pathology when compared to congenital malformations, although their true incidence may be underestimated. A variety of benign and malignant neoplasms may occur anywhere in the neural axis. Imaging plays an important role in the fetal tumor diagnosis and evaluation of their resultant complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pd.5722DOI Listing

Ribosomal Protein S27/Metallopanstimulin-1 (RPS27) in Glioma-A New Disease Biomarker?

Cancers (Basel) 2020 Apr 27;12(5). Epub 2020 Apr 27.

Tumorbiology Laboratory, Department of Neurosurgery, University of Würzburg, Josef-Schneider-Str. 11, D-97080 Würzburg, Germany.

Despite its significant overexpression in several malignant neoplasms, the expression of RPS27 in the central nervous system (CNS) is widely unknown. We identified the cell types expressing RPS27 in the CNS under normal and disease conditions. We acquired specimens of healthy brain (NB), adult pilocytic astrocytoma (PA) World Health Organization (WHO) grade I, anaplastic PA WHO grade III, gliomas WHO grade II/III with or without isocitrate dehydrogenase (IDH) mutation, and glioblastoma multiforme (GBM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers12051085DOI Listing

Association between Mental Disorders and Subsequent Medical Conditions.

N Engl J Med 2020 04;382(18):1721-1731

From the National Center for Register-based Research (N.C.M., O.P.-R., E.A., M.K.C., S.D., J.-C.P.G.D., T.M.L., P.B.M., K.L.M., C.B.P., L.V.P., B.V., N.W., J.J.M.), Center for Integrated Register-based Research (E.A., P.B.M., C.B.P.), the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C., M.F.-G., K.M.I., M.V., A.P.), the Center for Integrative Sequencing (A.D.B.), and the Big Data Center for Environment and Health (C.B.P.), Aarhus University, the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A., A.D.B., S.D., O.M., P.B.M., K.L.M., M.N., C.B.P., L.V.P., A.J.S., B.V., T.W.), the Center for Genomics and Personalized Medicine (A.D.B.), the Department of Neurology (J.-C.P.G.D.), and the Research Unit, Department of Psychosis (O.M.), Aarhus University Hospital, and the Research Unit for General Practice (M.F.-G., A.R.R., M.V., A.P.), Aarhus, the Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, Copenhagen University Hospital (M.E.B., M.N., H.J.S.), Psychiatric Center Copenhagen (L.V.K.), Faculty of Health and Medical Sciences (L.V.K.), the Department of Clinical Medicine (T.W.), and the Lundbeck Foundation GeoGenetics Center, GLOBE Institute (T.W.), University of Copenhagen, Copenhagen, and the Institute of Biological Psychiatry, Mental Health Center Sankt Hans, Mental Health Services Capital Region, Roskilde (A.J.S., T.W.) - all in Denmark; the National Drug and Alcohol Research Centre, University of New South Wales, Sydney (L.D.), the Department of General Practice, Melbourne Medical School, University of Melbourne, Melbourne, VIC (J.M.G.), and the Queensland Brain Institute (C.C.W.L., S.S., J.J.M.), Queensland Centre for Mental Health Research, the Park Centre for Mental Health (C.C.W.L., S.S., T.J.S., H.A.W., J.J.M.), and the School of Public Health, Faculty of Medicine (H.A.W.), University of Queensland, Brisbane - all in Australia; the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.), Heymans Institute, and the Interdisciplinary Center, Psychopathology and Emotion Regulation (P.J., A.M.R.), University of Groningen, Groningen, the Netherlands; the Department of Health Care Policy, Harvard Medical School, Boston (R.C.K.); the Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ (A.J.S.); the Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand (K.M.S.); Sievert Consulting, Minneapolis (C.S.); and the Institute for Health Metrics and Evaluation, University of Washington, Seattle (H.A.W.).

Background: Persons with mental disorders are at a higher risk than the general population for the subsequent development of certain medical conditions.

Methods: We used a population-based cohort from Danish national registries that included data on more than 5.9 million persons born in Denmark from 1900 through 2015 and followed them from 2000 through 2016, for a total of 83. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1915784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261506PMC

Cancer incidence and mortality trends in young adults in Metropolitan Lima young adults, 1990-2012.

Ecancermedicalscience 2020 20;14:1025. Epub 2020 Apr 20.

Department of Nuclear Medicine, National Institute of Neoplastic Diseases, Lima, Peru.

Aims: The purpose of this research was to calculate and compare standardised incidence and mortality ratios in young adults, based on the data published by the population-based cancer registry of Metropolitan Lima.

Method: A secondary analysis was carried out on the data published by the population-based cancer registry of Metropolitan Lima in its last five volumes. Calculating the standardised incidence ratio, in accordance with the World Health Organization's standard population, was done using the direct method, and the annual percentage change was calculated using the Joinpoint Regression Program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3332/ecancer.2020.1025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176066PMC

Therapy Based on the Regulation of Thiol-dependent Redox Systems.

Authors:
Jun Lu

Curr Med Chem 2020;27(12):1876-1877

College of Pharmaceutical Sciences Southwest University, Chongqing 400715, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/092986732712200423125214DOI Listing

Low-Dose Image-Guided Pediatric CNS Radiation Therapy: Final Analysis From a Prospective Low-Dose Cone-Beam CT Protocol From a Multinational Pediatrics Consortium.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820920650

Department of Radiation Oncology and Molecular Radiation Sciences, University of Minnesota, Minneapolis, MN, USA.

Background: Lower-dose cone-beam computed tomography protocols for image-guided radiotherapy may permit target localization while minimizing radiation exposure. We prospectively evaluated a lower-dose cone-beam protocol for central nervous system image-guided radiotherapy across a multinational pediatrics consortium.

Methods: Seven institutions prospectively employed a lower-dose cone-beam computed tomography central nervous system protocol (weighted average dose 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1533033820920650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225835PMC

The integrated stress response: From mechanism to disease.

Science 2020 04;368(6489)

Howard Hughes Medical Institute and Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, USA.

Protein quality control is essential for the proper function of cells and the organisms that they make up. The resulting loss of proteostasis, the processes by which the health of the cell's proteins is monitored and maintained at homeostasis, is associated with a wide range of age-related human diseases. Here, we highlight how the integrated stress response (ISR), a central signaling network that responds to proteostasis defects by tuning protein synthesis rates, impedes the formation of long-term memory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.aat5314DOI Listing

Cerebral Metastases.

N Engl J Med 2020 Apr;382(17):e36

Western University, London, ON, Canada

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMicm1906257DOI Listing

Single Solitary Fibrous Tumor Brain Metastasis in a Patient with Simultaneous Adenocarcinoma of the Lung: Case Report and Review of the Literature.

Case Rep Med 2020 7;2020:3938270. Epub 2020 Apr 7.

Department of Radiation Oncology, Cancer Care Northwest and Gamma Knife of Spokane, Spokane, WA, USA.

We present a unique case of a patient simultaneously diagnosed with solitary fibrous tumor (SFT) and unrelated adenocarcinoma of the lung, both proven with separate pathology. It was subsequently found that the SFT had metastasized to the brain by additional pathology, and not the predicted adenocarcinoma. SFTs are a rare mesenchymal neoplasm that accounts for less than 2% of all reported soft tissue tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/3938270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166291PMC

Cerebral hemispheric glioblastoma with PNET-like morphology and histone H3.3 G34 mutation in younger patients: Report of three rare cases and diagnostic pitfalls.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):262-266

Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.

Recurrent mutations in H3F3A that encodes the histone 3 variant H3.3, lead to amino acid substitutions including K27M and G34R/V-which are observed in high-grade gliomas (HGGs) of children and young adults. Previous studies have focused on gliomas with K27M mutation, whereas gliomas with G34R/V mutation have received little attention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_544_19DOI Listing

Laser Ablation of Abnormal Neurological Tissue Using Robotic NeuroBlate System (LAANTERN): 12-Month Outcomes and Quality of Life After Brain Tumor Ablation.

Neurosurgery 2020 Apr 21. Epub 2020 Apr 21.

Department of Neurosurgery, Washington University, St. Louis, Missouri.

Background: Laser Ablation of Abnormal Neurological Tissue using Robotic NeuroBlate System (LAANTERN) is an ongoing multicenter prospective NeuroBlate (Monteris Medical) LITT (laser interstitial thermal therapy) registry collecting real-world outcomes and quality-of-life (QoL) data.

Objective: To compare 12-mo outcomes from all subjects undergoing LITT for intracranial tumors/neoplasms.

Methods: Demographics, intraprocedural data, adverse events, QoL, hospitalizations, health economics, and survival data are collected; standard data management and monitoring occur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuros/nyaa071DOI Listing

Minimally invasive lateral approaches for the treatment of spinal tumors: single-position surgery without the "flip".

J Spine Surg 2020 Mar;6(1):62-71

Western Regional Center for Brain and Spine Surgery, Las Vegas, NV, USA.

Although primary tumors of the spine and neural elements are rare, metastatic disease to the spine is quite common. Traditionally, surgical treatment for spinal tumor patients involves open decompression with or without stabilization. The single-position minimally invasive (MIS) lateral approach, which has been recently described over the recent decade, allows simultaneous access to the anterior and posterior columns with the patient positioned in the lateral decubitus position. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/jss.2019.12.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154359PMC

cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading.

Brain Pathol 2020 Apr 19. Epub 2020 Apr 19.

International Agency for Research on Cancer, World Health Organization, Lyon, France.

cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12832DOI Listing
April 2020
3.840 Impact Factor

[Efficacy and safety of oral pyrotinib in HER2 positive metastatic breast cancer: real-world practice].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Apr;52(2):254-260

Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education; Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Pyrotinib, a novel irreversible pan-ErbB receptor tyrosine kinase inhibitor, showed promising antitumor activity and acceptable tolerability in phase II and phase III randomized clinical trials. We assessed the activity and safety of oral pyrotinib for human epidermal growth factor receptor 2 (HER2) positive metastatic breast cancer patients in the real world.

Methods: We retrospectively analyzed 72 HER2 positive metastatic breast cancer (MBC) patients who received oral pyrotinib based regimens at Beijing Cancer Hospital and other four hospitals (Peking University First Hospital, China-Japan Friendship Hospital, General Hospital of PLA, Peking University Third Hospital) from August 2018 to September 2019. Read More

View Article

Download full-text PDF

Source