3,166,891 results match your criteria Neoplasia New York N.Y.[Journal]


[Complications of transperineal template-guided prostate mapping biopsy].

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):428-431

Department of Urology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.

To assess the complications of transperineal template-guided prostate mapping biopsy (TTMB). Between May 2017 and March 2018, 142 consecutive patients with prior negative transrectal biopsy results and persistently elevated prostate-specific antigen (PSA) were divided into the observation group and the control group randomly. The observation group underwent TTMB and the control group underwent transperineal template-guided prostate saturation biopsy (TTSB). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.009DOI Listing
February 2019

Abdominal CT evaluation of the liver and spleen for staging mast cell tumors in dogs yields nonspecific results.

Vet Radiol Ultrasound 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Sciences and Services, The Royal Veterinary College, North Mymms, Hatfield, AL9 7TA, UK.

Canine mast cell tumor staging is commonly performed using abdominal ultrasonography and fine-needle aspiration cytology of masses, lymph nodes, and hepatic and splenic parenchyma. Computed tomography is used for abdominal, thoracic, or whole body imaging in staging mast cell tumors in the authors' institution enabling evaluation of multiple body areas in one examination. The aim of this study was to compare the CT examinations acquired for staging of mast cell disease to their subsequent liver and spleen cytology findings. Read More

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http://dx.doi.org/10.1111/vru.12717DOI Listing
February 2019

Early-stage serrated adenocarcinomas are divided into several molecularly distinct subtypes.

PLoS One 2019 20;14(2):e0211477. Epub 2019 Feb 20.

Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Serrated adenocarcinoma (SAC) is considered the end stage of the serrated neoplasia pathway. Although SAC prognosis is not widely recognized, the serrated pathway-associated subtype consistently exhibits unfavorable prognosis in genetic studies. Herein, we classified molecularly distinct subtypes of serrated adenocarcinomas and clarified their associated clinicopathological characteristics and genetic changes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211477PLOS
February 2019

More on Blastic Plasmacytoid Dendritic-Cell Neoplasms.

N Engl J Med 2019 Feb 14;380(7):696. Epub 2019 Feb 14.

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February 2019

More on Blastic Plasmacytoid Dendritic-Cell Neoplasms.

N Engl J Med 2019 Feb 14;380(7):695-6. Epub 2019 Feb 14.

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February 2019

Can Neutrophil-to-Lymphocyte ratio predict the response to BCG in high-risk non muscle invasive bladder cancer?

Int Braz J Urol 2018 Nov 3;45. Epub 2018 Nov 3.

Department of Urology, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del Sacro Cuore di Roma.

Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy.

Materials And Methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group). Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0249DOI Listing
November 2018

Pre-analytical parameters associated with unsuccessful karyotyping in myeloid neoplasm: a study of 421 samples.

Braz J Med Biol Res 2019 Feb 14;52(2):e8194. Epub 2019 Feb 14.

Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.

Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75). Read More

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http://dx.doi.org/10.1590/1414-431X20188194DOI Listing
February 2019

Ruxolitinib treatment reduces monocytic superoxide radical formation without affecting hydrogen peroxide formation or systemic oxidative nucleoside damage in myelofibrosis.

Leuk Lymphoma 2019 Feb 20:1-9. Epub 2019 Feb 20.

b Institute for Inflammation Research (IIR), Center for Rheumatology and Spine Diseases, Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

The role of excess reactive oxygen species (ROS) with consequent DNA/RNA damage is now recognized as a hallmark of cancer. In JAK2V617F mutated myeloproliferative neoplasms, ROS have been suggested to be important factors in disease initiation and progression. Ruxolitinib is the most widely used drug for myelofibrosis, because it improves symptom-score. Read More

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http://dx.doi.org/10.1080/10428194.2019.1579323DOI Listing
February 2019

Frozen Section Diagnosis of Ovarian Epithelial Tumors: Diagnostic Pearls and Pitfalls.

Authors:
Natalia Buza

Arch Pathol Lab Med 2019 Jan;143(1):47-64

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Epithelial tumors of the ovary are one of the most frequently encountered gynecologic specimens in the frozen section laboratory. The preoperative diagnostic workup of an ovarian mass is typically limited to imaging studies and serum markers, both of which suffer from low sensitivity and specificity. Read More

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http://dx.doi.org/10.5858/arpa.2018-0289-RADOI Listing
January 2019

A case report of esophageal actinomycosis in an immunocompetent patient and review of the literature.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Laboratory of Microbiology and Virology, National Institute of Gastroenterology "S. De Bellis", Research Hospital, Castellana Grotte, Bari 70013, Italy.

Actinomycosis is a rare, chronic and slowly progressive granulomatous disease caused by Actinomyces spp., a Gram-positive anaerobic bacterium that rarely affects the esophagus. Although this infection is uncommon, it has been reported in both immunocompromised and immunocompetent individuals. Read More

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February 2019

Malignant peripheral nerve sheath tumor of the pancreas-A case report.

Int J Surg Case Rep 2019 Feb 13;55:239-242. Epub 2019 Feb 13.

Department of General Surgery, Department of Surgical Gastroentrology, Saveetha Medical College Hospital, India.

Introduction: Nerve sheath tumors are tumors arising from nerve sheaths or which show nerve sheath differentiation. They are divided as benign and malignant. They are associated with Von Recklinghausen syndrome. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.011DOI Listing
February 2019

The inhibitory effect of polysaccharide from Rhizopus nigricans on colitis-associated colorectal cancer.

Biomed Pharmacother 2019 Feb 18;112:108593. Epub 2019 Feb 18.

National Glycoengineering Research Center and School of Life Science, Shandong University, Qingdao 266237, PR China. Electronic address:

An extracellular polysaccharide (EPS1-1) of Rhizopus nigricans was found to enhance immunity and reduce colon cancer cell proliferation. Here, the effect of EPS1-1 on a mouse model of colitis-associated cancer (CAC) induced by azoxymethane (AOM)/dextran sodium sulfate (DSS) was investigated. Pathological symptoms, including weight loss, piloerection, hematochezia and insensitivity caused by AOM/DSS, were relieved by EPS1-1. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.01.054DOI Listing
February 2019

Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers.

Endocrinol Metab (Seoul) 2019 Feb 15. Epub 2019 Feb 15.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of mutually-exclusive oncogenic alterations affecting and proto-oncogenes in all stages of thyroid cancer. Initially identified by traditional sequencing approaches, the NGS studies also confirmed the acquisition of alterations that inactivate tumor protein p53 () and activate phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha () in advanced thyroid cancers. Read More

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February 2019

Prevalence of pulmonary nodules in dogs with malignant neoplasia as determined by CT.

Vet Radiol Ultrasound 2019 Feb 19. Epub 2019 Feb 19.

Department of Clinical Sciences and Services, The Royal Veterinary College, Hertfordshire, United Kingdom.

In order to estimate the prevalence of pulmonary nodules in dogs with nonpulmonary malignant neoplasia, medical record descriptions of CT findings in dogs diagnosed with nonpulmonary malignant neoplasia were reviewed retrospectively. A total of 536 dogs were sampled from a single hospital. For malignant neoplasms with >10 affected individuals, prevalence of multiple pulmonary nodules at first CT was hemangiosarcoma 24 of 58 (41%), osteosarcoma 14 of 55 (26%), carcinoma 20 of 80 (25%), histiocytic sarcoma five of twenty-one (24%), soft tissue sarcoma 13 of 57 (23%), adenocarcinoma 11 of 60 (18%), melanoma five of thirty-seven (14%), lymphoma 10 of 76 (13%), mast cell tumor two of forty-seven (4%), and squamous cell carcinoma zero of seventeen (0%). Read More

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http://dx.doi.org/10.1111/vru.12723DOI Listing
February 2019

Dilemmas in Diagnosis and Management of Gastroenteropancreatic Mixed Neuroendocrine Non-neuroendocrine Neoplasms: First Single-Centre Report from India.

J Gastrointest Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgical Oncology, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, 400050, India.

Purpose: Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is a rare neoplasm comprising of exocrine and neuroendocrine elements, each representing ≥ 30% lesion. It is commonly misdiagnosed as adenocarcinoma or grade-3 neuroendocrine neoplasm (NEN). Management is not well-defined. Read More

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http://dx.doi.org/10.1007/s12029-019-00213-0DOI Listing
February 2019

Adaptive hypofractionated gamma knife radiosurgery in the acute management of brainstem metastases.

Surg Neurol Int 2019 29;10:14. Epub 2019 Jan 29.

Department of Neurosurgery, Karolinska University Hospital, Solna, Sweden.

Background: Intrinsic brainstem metastases are life-threatening neoplasms requiring rapid, effective intervention. Microsurgery is considered not feasible in most cases and systemic treatment seldom provides a successful outcome. In this context, radiation therapy remains the best option but adverse radiation effects (ARE) remain a major concern. Read More

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http://dx.doi.org/10.4103/sni.sni_53_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367951PMC
January 2019

Short- and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors.

World J Gastroenterol 2019 Feb;25(6):707-718

Department of Innovative Interventional Endoscopy Research, The Jikei University School of Medicine, Tokyo 105-8461, Japan.

Background: It is widely recognized that endoscopic resection (ER) of superficial non-ampullary duodenal epithelial tumors (SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and perforation. These adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short- and long-term outcomes have not been standardized yet. Read More

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http://dx.doi.org/10.3748/wjg.v25.i6.707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378536PMC
February 2019

The repair using a fibular graft of cervical vertebral collapse due to renal cell carcinoma: Late results with a case report.

J Craniovertebr Junction Spine 2018 Oct-Dec;9(4):267-270

Department of Pathology, Research and Training Hospital, Recep Tayyip Erdogan University, Rize, Turkey.

The most common cause of spinal tumors is metastases, but the cervical vertebra is the least common region of spinal metastasis, and relatively, little is published about surgery in metastasis to the cervical vertebra. While spinal metastasis is most often caused by neoplasms originating from the lung, breast, and prostate, renal cell carcinoma (RCC) metastasis is very rare. A 47-year-old patient introduced here presented with severe pain spontaneously on his neck and in his arm. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_32_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364372PMC
February 2019

Prostate care and prostate cancer from the perspectives of undiagnosed men: a systematic review of qualitative research.

BMJ Open 2019 Jan 28;9(1):e022842. Epub 2019 Jan 28.

Clinical Registry Unit, Department of Epidemiology and Preventive Medicine, Monash University Australia, Melbourne, Victoria, Australia.

Objectives: To summarise and evaluate evidence from men who had not been diagnosed with prostate cancer about their perspectives on prostate care and prostate cancer.

Design: A systematic review of qualitative research, on the perspectives of non-cancerous men regarding prostate cancer prevention and care.

Setting: A wide range of settings including primary and secondary care. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022842DOI Listing
January 2019

Allyl-isothiocyanate ameliorates the pre-neoplastic changes induced by the fern Dryopteris nigropalaceae on experimental feeding in Guinea pigs.

Res Vet Sci 2019 Feb 16;124:24-31. Epub 2019 Feb 16.

ICAR-Indian Veterinary Research Institute, Regional Station, Palampur 176061, India.

Enzootic bovine haematuria, caused by long-term ingestion of ferns, is a chronic disease of hill cattle characterized by neoplastic lesions in the urinary bladder. Objectives of this study were to investigate the toxicity potential of long-term feeding of the fern Dryopteris nigropalaceae and effect of allyl isothiocyanate (AITC) to ameliorate fern toxicity and the associated pathological changes. The LC-MS analysis of the fern showed presence of ptaquiloside (4. Read More

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http://dx.doi.org/10.1016/j.rvsc.2019.02.003DOI Listing
February 2019

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer.

BMC Cancer 2019 Feb 19;19(1):160. Epub 2019 Feb 19.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, Vrije Universiteit, De Boelelaan 1117, Rm 3A46, Amsterdam, 1081, HV, the Netherlands.

Background: The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, but has not yet been validated in hospitalized patients with advanced cancer, although the DOS is commonly used in this setting in daily practice. The aim of this study was to evaluate the accuracy of the DOS in hospitalized patients with advanced cancer using the revised version of the Delirium Rating Scale (DRS-R) as the gold standard. Read More

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http://dx.doi.org/10.1186/s12885-019-5351-8DOI Listing
February 2019

Multiple endocrine neoplasia type 1.

Expert Rev Endocrinol Metab 2009 Jul;4(4):371-388

d Department of Metabolic and Endocrine Diseases, PO Box 85090, 3508 AB Utrecht.

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal-dominant inherited tumor syndrome characterized by hyperplasia and/or tumors in the parathyroid glands, the pancreatic islets, the anterior pituitary and adrenal glands, as well as neuroendocrine tumors in the thymus, lungs and stomach, and tumors in nonendocrine tissues. In 1997, the responsible MEN1 gene was identified as a tumor-suppressor gene and its product was named menin. In this review, guidelines for early diagnosis, including MEN1 gene mutation analysis, and treatment, including periodic clinical monitoring, have been formulated, enabling improvement of life expectancy and quality of life. Read More

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http://dx.doi.org/10.1586/eem.09.22DOI Listing

Opioid-induced biochemical alterations of the neuroendocrine axis.

Expert Rev Endocrinol Metab 2011 Sep;6(5):705-713

a Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, TX, USA.

Exogenous opioids have been used for decades to palliate cancer-related pain and other cancer-related manifestations and, more recently, to treat patients with pain not related to oncologic disease. While the goal of opioid treatment is symptomatic relief and improved quality of life, these patients often suffer from adverse side effects, including endocrine system abnormalities, of which hypogonadism is the best known. Opioids may interact with other hypothalamic-pituitary pathways and endocrine end organs, and in most cases these interactions are subtle and the effects unclear. Read More

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http://dx.doi.org/10.1586/eem.11.55DOI Listing
September 2011

Predicting response: identifying molecular determinants of endocrine response and resistance in breast cancer.

Authors:
Alison J Butt

Expert Rev Endocrinol Metab 2011 Sep;6(5):661-663

a Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia and St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia.

Evaluation of: Fernandez-Cuesta L, Anaganti S, Hainaut P, Olivier M. p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines. Int. Read More

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http://dx.doi.org/10.1586/eem.11.53DOI Listing
September 2011

Recent results of basic and clinical research in MEN1: opportunities to improve early detection and treatment.

Expert Rev Endocrinol Metab 2012 May;7(3):331-344

c Department of Metabolic Diseases, University Medical Center, Utrecht, The Netherlands.

Due to the variable expression of multiple endocrine neoplasia type 1 (MEN1), it is difficult to predict the course of the disease. However, knowledge about the normal function of the MEN1 gene product, together with the effects of cellular derangement by subsequent genetic events, has increased considerably. At first, the possible existence of a genotype-phenotype correlation is discussed. Read More

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http://dx.doi.org/10.1586/eem.12.22DOI Listing

Prophylactic thyroidectomy in multiple endocrine neoplasia type 2.

Expert Rev Endocrinol Metab 2010 Nov;5(6):867-874

a Endocrine Practice and Molecular Laboratory, Brückenstr. 21, 69120 Heidelberg, Germany.

Medullary thyroid carcinoma (MTC) is the main component of the autosomal dominant cancer syndrome multiple endocrine neoplasia type 2 (MEN 2). MEN 2 is caused by autosomal dominant gain-of-function mutations in the RET proto-oncogene. In RET-mutation carriers, an age-related progression has been documented from normal C-cells to premalignant C-cell hyperplasia and finally to MTC with or without cervical lymph node metastases. Read More

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http://dx.doi.org/10.1586/eem.10.58DOI Listing
November 2010

Activation of TF-Dependent Blood Coagulation Pathway and VEGF-A in Patients with Essential Thrombocythemia.

Medicina (Kaunas) 2019 Feb 16;55(2). Epub 2019 Feb 16.

Department of Pathophysiology, Faculty of Pharmacy, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, Poland.

Recent studies suggest that a vascular endothelial growth factor (VEGF-A) may be involved in the thrombotic process by stimulating the expression of tissue factor in vascular endothelial cells. Tissue factor (TF) can also stimulate the transcription of the gene encoding VEGF-A. The relationship between coagulation and angiogenesis in myeloproliferative neoplasms is not fully understood. Read More

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http://dx.doi.org/10.3390/medicina55020054DOI Listing
February 2019

Relationship between type of unprovoked venous thromboembolism and cancer location: An individual patient data meta-analysis.

Thromb Res 2019 Feb 13;176:79-84. Epub 2019 Feb 13.

Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Canada.

Background: Unprovoked venous thromboembolism (VTE) may be the first manifestation of an underlying cancer. We aimed to assess the period prevalence of occult cancer detection stratified by VTE location (deep vein thrombosis [DVT], pulmonary embolism [PE] or both) and the anatomical relationship between occult cancer and VTE.

Methods: Post-hoc analysis of a systematic review and individual patient data meta-analysis of adults with unprovoked VTE with at least 12 months of follow-up. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.011DOI Listing
February 2019

Non-neuroendocrine neoplasms of the pituitary region.

J Clin Endocrinol Metab 2019 Feb 19. Epub 2019 Feb 19.

Centre for Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom.

Context: Although the majority of sellar lesions are related to pituitary adenomas, the region gives rise to a variety of neoplasms that can be associated with substantial morbidity and/or mortality.

Evidence Acquisition: Information from reviews and guidelines of relevant societies dealing with such neoplasms, and articles that have provided new developments which made important contributions in their pathogenesis and treatment up to 2018, were obtained: public indexes such as PubMed/MEDLINE were used with the search items.

Evidence Synthesis: Sellar neoplasms have a worse outcome than pituitary adenomas that is related not only to their natural history but also to side effects of therapies and evolving endocrine and/or hypothalamic deficiencies. Read More

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http://dx.doi.org/10.1210/jc.2018-01871DOI Listing
February 2019

Epstein-Barr virus-associated gastric ulcer mimicking gastric neoplasia: a case report.

Med Ultrason 2019 Feb;21(1):96-98

Department of Gastroenterology, Regional Institute of Gastroenterology and Hepatology Prof. Dr. Octavian Fodor, Cluj-Napoca, Romania.

We describe a rare case of a severe gastric ulcer of a 66-year-old immunocompetent man who was associated with primary Epstein-Barr virus (EBV) infection and temporarily misdiagnosed with gastric lymphoma. A contrast-enhanced computed tomography (CT-scan) of the thorax, abdomen and pelvis followed by EUS revealed a neoplastic infiltrative-ulcerative semicircumferentialgastric mass and a 1 cm large satellite adenopathy, being classified as T3N1M0 gastric neoplasia. The histological analysis of the ¾ distal stomach and lymph node sthat were resected contradicted the initial biopsy report, suggesting EBV gastric ulcer, etiology confirmed by the in situ hybridization technique. Read More

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http://dx.doi.org/10.11152/mu-1560DOI Listing
February 2019

Role of Close Endocervical Margin in Treatment Failure After Cervical Excision for Cervical Intraepithelial Neoplasia: A Retrospective Study.

Arch Pathol Lab Med 2019 Feb 19. Epub 2019 Feb 19.

From the Gynecological Oncology Unit (Drs Sopracordevole and del Fabro and Ms Buttignol).

Context.—: A significant negative trend in length of cone excision has been observed in recent years, leading to a higher percentage of positive endocervical excision margin and close (<1 mm) negative endocervical margin.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2018-0363-OADOI Listing
February 2019

High-Grade Sinonasal Carcinoma: Classification Through Molecular Profiling.

Arch Pathol Lab Med 2019 Feb 19. Epub 2019 Feb 19.

From the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston.

High-grade sinonasal carcinomas are a cohort of malignant epithelial neoplasms arising in the sinonasal cavities with distinct, ominous morphologic features or lacking well-differentiated features that might otherwise classify them as less biologically worrisome. Recent advances in molecular profiling have led to the identification of several distinct tumor entities previously grouped together. These molecularly distinct lesions include NUT (midline) carcinoma, INI1 ( SMARCB1)-deficient carcinoma, SMARCA4-deficient sinonasal carcinoma, and novel IDH-mutant sinonasal undifferentiated carcinoma, in addition to the previously described lymphoepithelial carcinoma that may also be included in the differential diagnosis. Read More

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http://dx.doi.org/10.5858/arpa.2018-0224-RSDOI Listing
February 2019

Staging soft tissue sarcoma of the head and neck: Evaluation of the AJCC 8th edition revised T classifications.

Authors:
Justin M M Cates

Head Neck 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, Microbiology and Immunology, Division of Anatomic Pathology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: The American Joint Committee on Cancer (AJCC) has proposed new T classifications for head and neck sarcomas in the 8th edition of the AJCC Cancer Staging Manual, but these classifications have not been evaluated for prognostic utility in tumor staging.

Methods: The predictive ability of revised AJCC T classifications was evaluated by nonlinear multivariable regression using records from the Surveillance, Epidemiology, and End Results database (N = 2756). A proposed staging algorithm was developed using a subset of records and compared to the AJCC 7th edition using a separate validation dataset. Read More

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http://dx.doi.org/10.1002/hed.25701DOI Listing
February 2019

Should progesterone and estrogens receptors be assessed for predicting the response to conservative treatment of endometrial hyperplasia and cancer? A systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2019 Feb 19. Epub 2019 Feb 19.

Obstetrics and Gynecology Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Introduction: Progestins are used as conservative treatment of endometrial hyperplasia (EH) and early endometrial cancer (EEC). We aimed to assess if immunohistochemical expression of estrogens and progesterone receptors (ER and PR) predicts the treatment response.

Material And Methods: Electronic databases were searched for studies assessing ER and PR expression in EH and EEC treated with progestins. Read More

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http://doi.wiley.com/10.1111/aogs.13586
Publisher Site
http://dx.doi.org/10.1111/aogs.13586DOI Listing
February 2019
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Does the use of incretin-based medications increase the risk of cancer in patients with type-2 diabetes mellitus?

Pharmacoepidemiol Drug Saf 2019 Feb 18. Epub 2019 Feb 18.

Department of Oncology, Queen's University, Kingston, Ontario, Canada.

Purpose: Incretin-based medications are a novel class of agents for the treatment of type-2 diabetes mellitus (DM2). The safety profile of these medications is not firmly established, and concerns have been raised about their potential carcinogenicity. The objective of our study was to produce new evidence on the effect of incretin-based medications on cancer risk in patients with DM2. Read More

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http://dx.doi.org/10.1002/pds.4746DOI Listing
February 2019

FISH and FICTION in Lymphoma Research.

Methods Mol Biol 2019 ;1956:249-267

Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

Fluorescence in situ hybridization (FISH) is a powerful and robust technique allowing the visualization of target sequences like genes in interphase nuclei. It is widely used in routine diagnostics to identify cancer-specific aberrations including lymphoma-associated translocations or gene copy number changes in single tumor cells. By combining FISH with immunophenotyping-a technique called fluorescence immunophenotyping and interphase cytogenetic as a tool for investigation of neoplasia (FICTION)-it is moreover possible to identify a cell population of interest. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_11DOI Listing
January 2019

Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas.

Methods Mol Biol 2019 ;1956:139-155

Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece.

Comprehensive analysis of the clonotypic B cell receptor immunoglobulin (BcR IG) gene rearrangement sequences in patients with mature B cell neoplasms has led to the identification of significant repertoire restrictions, culminating in the discovery of subsets of patients expressing highly similar, stereotyped BcR IG. This finding strongly supports selection by common epitopes or classes of structurally similar epitopes in the ontogeny of these tumors. BcR IG stereotypy was initially described in chronic lymphocytic leukemia (CLL), where the stereotyped fraction of the disease accounts for a remarkable one-third of patients. Read More

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http://dx.doi.org/10.1007/978-1-4939-9151-8_7DOI Listing
January 2019

Hospitalization rate in offspring of cancer survivors: a national cohort study.

J Cancer Surviv 2019 Feb 18. Epub 2019 Feb 18.

Center for Primary Health Care Research, Lund University/Region Skåne, Malmö University Hospital, CRC, floor 11, building 28, entrance 72, 205 02, Malmö, Sweden.

Purpose: The number of childbirths among cancer survivors continues to increase, but it is still largely unknown whether the children of cancer survivors might experience adverse health outcomes during the process of growing up.

Methods: We identified all individuals diagnosed with cancer between 1958 and 2015 from the Swedish Cancer Registry and linked them to the Swedish Medical Birth Register to identify their offspring born between 1997 and 2015. Up to 10 children, whose parents did not have a diagnosis of cancer, were matched with the study population according to date of birth and gender. Read More

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http://dx.doi.org/10.1007/s11764-019-00741-5DOI Listing
February 2019

Oncostatin M receptor, positively regulated by SP1, promotes gastric cancer growth and metastasis upon treatment with Oncostatin M.

Gastric Cancer 2019 Feb 18. Epub 2019 Feb 18.

Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Background: Oncostatin M receptor (OSMR) is a member of the interleukin 6 (IL-6) receptor family that transduces signaling events of Oncostatin M (OSM). OSM-OSMR signaling plays a key role in inflammation and cancer progression. However, the role of OSM-OSMR in gastric cancer (GC) is still unknown. Read More

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http://dx.doi.org/10.1007/s10120-019-00934-yDOI Listing
February 2019

Two-Year Follow-Up of a Multi-centre Randomized Controlled Trial to Study Effectiveness of a Hospital-Based Work Support Intervention for Cancer Patients.

J Occup Rehabil 2019 Feb 16. Epub 2019 Feb 16.

Coronel Institute of Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Purpose Purpose is to: (1) study effectiveness of the hospital-based work support intervention for cancer patients at two years of follow-up compared to usual care and (2) identify which early factors predict time to return-to-work (RTW). Methods In this multi-center randomised controlled trial (RCT), 106 (self-)employed cancer patients were randomized to an intervention group or control group and provided 2 years of follow-up data. The intervention group received patient education and work-related support at the hospital. Read More

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http://dx.doi.org/10.1007/s10926-019-09831-8DOI Listing
February 2019

MR findings of uterine PEComa in patients with tuberous sclerosis: report of two cases.

Abdom Radiol (NY) 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8576, Japan.

Tuberous sclerosis complex (TSC), a rare autosomal dominant neurocutaneous disorder, is characterized by the presence of benign congenital tumors in multiple organs. Neoplasms with perivascular epithelioid cell differentiation (PEComas), including angiomyolipoma (AML) and lymphangioleiomyomatosis (LAM), can occur in association with TSC. This report describes two cases of uterine PEComas presenting characteristic MR imaging features reflecting pathological findings. Read More

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http://dx.doi.org/10.1007/s00261-019-01918-3DOI Listing
February 2019

Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease.

Sci Rep 2019 Feb 18;9(1):2209. Epub 2019 Feb 18.

Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA, 99164-4236, USA.

Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Read More

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http://dx.doi.org/10.1038/s41598-019-38741-1DOI Listing
February 2019

CT Enhancement and 3D Texture Analysis of Pancreatic Neuroendocrine Neoplasms.

Sci Rep 2019 Feb 18;9(1):2176. Epub 2019 Feb 18.

Department of Pathology, Pancreas Institute, G.B. Rossi Hospital - University of Verona, Verona, Italy.

To evaluate pancreatic neuroendocrine neoplasms (panNENs) grade prediction by means of qualitative and quantitative CT evaluation, and 3D CT-texture analysis. Patients with histopathologically-proven panNEN, availability of Ki67% values and pre-treatment CT were included. CT images were retrospectively reviewed, and qualitative and quantitative images analysis were done; for quantitative analysis four enhancement-ratios and three permeability-ratios were created. Read More

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http://dx.doi.org/10.1038/s41598-018-38459-6DOI Listing
February 2019

Primary cystic neuroendocrine tumor of the liver: case report

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):505-509. Epub 2019 Jan 28.

Instituto Mexicano del Seguro Social, Hospital de Especialidades "Dr. Bernardo Sepúlveda Gutiérrez", Servicio de Anatomía Patológica. Ciudad de México, México

Background: 85% of neuroendocrine tumors (NET) originate in the gastrointestinal tract, which is why their primary hepatic location is very rare; NETs most frequently cause metastases to the liver; so when diagnosed, a hepatic NET is considered initially metastatic. Diagnosis of primary hepatic neuroendocrine tumors (PHNET) should be performed by excluding extrahepatic NETs and through histological confirmation. The objective of this article is to present a case of PHNET. Read More

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January 2019

Mortality in the elderly: A socio-spatial analysis based on the degree of social deprivation

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):447-455. Epub 2019 Jan 28.

Secretaría de Salud, Instituto Nacional de Geriatría, Dirección de Investigación. Ciudad de México, México

Background: Mortality in Mexico has decreased substantially in the last years; however, there are segments of the population that experience social deprivation.

Objective: To identify and describe at the national level the causes of death by degree of social deprivation (DSD), age and sex.

Methods: We analyzed variables from the Censo de Vivienda y Población (Census of Population and Housing) and data from statistics of mortality and DSD, all information corresponding to 2010. Read More

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January 2019

Current situation of soft tissue sarcomas: Registry of a Latin American cancer institute.

Cir Esp 2019 Feb 16. Epub 2019 Feb 16.

Departamento de mamas, piel y tumores de partes blandas, Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú.

Introduction: Soft tissue sarcomas (SFT) are a group of rare and heterogeneous neoplasms (representing less than 1% of cancer in adults and 15% in pediatric patients), for which there is no updated records in the Latin American population. This study aims to describe the current situation of patients treated at a cancer institute in Latin America.

Methods: We obtained records from 250 patients with a diagnosis of SFT, treated at the National Institute of Neoplastic Diseases of Peru (INEN) during the period 2009-2013, with a mean follow-up of 62 months. Read More

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http://dx.doi.org/10.1016/j.ciresp.2019.01.005DOI Listing
February 2019

The diagnostic utility of retroperitoneoscopic tissue biopsy for unresectable retroperitoneal lesions excluding urogenital cancers.

World J Surg Oncol 2019 Feb 18;17(1):35. Epub 2019 Feb 18.

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Retroperitoneal tumors are an uncommon disease known to consist of a diverse group of benign and malignant neoplasms. Treatment of unresectable retroperitoneal lesions requires pathological diagnosis. Here, we report the utility and safety of retroperitoneoscopic biopsy for unresectable retroperitoneal lesions excluding urogenital cancers. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-019-1
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http://dx.doi.org/10.1186/s12957-019-1581-0DOI Listing
February 2019
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Clinical Characteristics, Complications, and Reasons for Readmission following Lingual Tonsillectomy.

Otolaryngol Head Neck Surg 2019 Feb 19:194599819827820. Epub 2019 Feb 19.

2 Department of Otology & Laryngology, Harvard Medical School, Boston, Massachusetts, USA.

This brief communication regards the indications and complications for and rates of readmission following lingual tonsillectomy. The National Readmissions Database (NRD) 2013-2014 was queried for all cases of lingual tonsillectomy occurring from 2013 to 2014. Among 602 lingual tonsillectomies (mean age 36. Read More

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http://dx.doi.org/10.1177/0194599819827820DOI Listing
February 2019

Korean First Prospective Phase II Study, Feasibility of Prone Position in Postoperative Whole Breast Radiotherapy: A Dosimetric Comparison.

Cancer Res Treat 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: This first Korean prospective study is to evaluate the feasibility of prone breast radiotherapy after breast conserving surgery for left breast cancer patients who have relatively small breast size and we present dosimetric comparison between prone and supine positions.

Materials And Methods: Fifty patients underwent two computed tomography (CT) simulations in supine and prone positions. Whole breast, ipsilateral lung, heart, and left-anterior-descending coronary artery were contoured on each simulation CT images. Read More

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http://dx.doi.org/10.4143/crt.2018.423DOI Listing
February 2019

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program.

Cancer Res Treat 2019 Feb 19. Epub 2019 Feb 19.

National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement national cancer screening program in Korea.

Methods: Multidisciplinary expert committee was comprised to develop a standardized protocol forKorean Lung Cancer Screening Project (K-LUCAS). Read More

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http://dx.doi.org/10.4143/crt.2018.464DOI Listing
February 2019
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