3,192,312 results match your criteria Neoplasia New York N.Y.[Journal]


Detecting Early Pancreatic Cancer: Current Problems and Future Prospects.

Gut Liver 2019 Apr 23. Epub 2019 Apr 23.

Divisions of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

The number of patients with pancreatic cancer (PC) is currently increasing in both Korea and Japan. The 5-year survival rate of patients with PC 13.0%; however, resection with minimal invasion (tumor size: ≤10 mm) increases the 5-year survival rate to 80%. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18491DOI Listing
April 2019
1 Read

Possible drop metastasis after treatment of renal cell carcinoma with percutaneous cryoablation.

Urology 2019 Apr 19. Epub 2019 Apr 19.

Division of Urology and Urologic Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA.

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http://dx.doi.org/10.1016/j.urology.2019.04.010DOI Listing

Uncommon Histopathological Variants of Malignant Melanoma. Part 2.

Am J Dermatopathol 2019 May;41(5):321-342

Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria.

Despite new horizons opened by recent advances in molecular pathology, histological evaluation still remains the diagnostic gold standard regarding cutaneous melanocytic neoplasms. Several histological variants of melanoma have been described, and their knowledge is crucial for accurate diagnosis and classification of cases with unusual clinico-pathological features. Uncommon histological variants of melanoma have been described based on a broad constellation of features, including architectural pattern, stromal alterations, cytological attributes, and other morphological properties. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001226DOI Listing

Novel Circulating miRNA Signatures for Early Detection of Pancreatic Neoplasia.

Clin Transl Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Gastrointestinal & Pancreatic Oncology Group, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)/Hospital Clínic of Barcelona/Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Catalonia, Spain.

Objectives: Pancreatic ductal adenocarcinoma (PDAC) presents the lowest survival rate of all cancers because only 6% of patients reach five-year survival. Alterations in the expression of several microRNAs (miRNAs) occur in the tumor of PDAC and in preneoplastic lesions as the called intraductal papillary mucinous neoplasm (IPMN). Here, we aimed at identifying which miRNAs are significantly altered in liquid biopsies from patients with PDAC and IPMN to find new noninvasive biomarkers for early detection of PDAC. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000029DOI Listing

Thoracic Manifestations of Genitourinary Neoplasms and Treatment-related Complications.

J Thorac Imaging 2019 May;34(3):W36-W48

Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, KS.

Genitourinary (GU) malignancies are a diverse group of common and uncommon neoplasms that may be associated with significant mortality. Metastases from GU neoplasms are frequently encountered in the chest, and virtually all thoracic structures can be involved. Although the most common imaging manifestations include hematogenous dissemination manifesting with peripheral predominant bilateral pulmonary nodules and lymphatic metastases manifesting with mediastinal and hilar lymphadenopathy, some GU malignancies exhibit unique features. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000382DOI Listing

PD-L1 Expression and Tumor-infiltrating Lymphocytes in Uterine Smooth Muscle Tumors: Implications for Immunotherapy.

Am J Surg Pathol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology, University of Virginia, Charlottesville, VA.

Immunotherapies targeting the PD-1/PD-L1 checkpoint axis are of growing interest for the treatment of mesenchymal neoplasms. However, PD-L1 expression and tumor-associated lymphocytes have not been well-investigated in uterine smooth muscle tumors. Forty-nine uterine smooth muscle tumors (23 leiomyosarcomas, 8 smooth muscle tumors of uncertain malignant potential [STUMP], 7 atypical leiomyomas, and 11 benign leiomyomas) were evaluated for tumoral and tumor-associated immune PD-L1 expression and tumor-associated T-cell infiltration. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001254DOI Listing

Renal cell carcinoma originating in the free wall of simple renal cyst: Two unusual case reports with literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15249

Peking University China-Japan Friendship School of Clinical Medicine.

Rationale: Simple renal cyst (SRC) is a benign disease. However, rarely renal cell carcinoma (RCC) may be raised at the wall of a preexisting SRC. We herein describe 2 unusual cases of RCC arising from the outer surface of the free wall of the renal cyst. Read More

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http://dx.doi.org/10.1097/MD.0000000000015249DOI Listing

An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15246

Peking University China-Japan Friendship School of Clinical Medicine.

Rationale: Mucinous cystic neoplasms (MCNs) are relatively rare lesions, accounting for 2%-5% of all exocrine pancreatic neoplasms. MCNs mainly occur in women (female:male ratio = 20:1), with a peak incidence in the 5th decade of life. Osteoclast-like giant cell tumors (OGCTs) are rare and relatively aggressive neoplasms, comprising <1% of all pancreatic carcinomas. Read More

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http://dx.doi.org/10.1097/MD.0000000000015246DOI Listing

A case report on metastatic ileal neuroendocrine neoplasm to the breast masquerading as primary breast cancer: A diagnostic challenge and management dilemma.

Medicine (Baltimore) 2019 Apr;98(16):e14989

1st Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Rationale: Metastatic neuroendocrine neoplasms (NENs) to the breast are very rare entities comprising only 1% to 2% of all metastatic breast tumors. In this article, we describe a case of a neuroendocrine ileal neoplasm metastatic to breast and liver, with breast metastatic tumor to be the initial manifestation of the disease.

Patient Concerns: We herein report a rare case of a female patient admitted to our department with a palpable painful mass on her left breast. Read More

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http://dx.doi.org/10.1097/MD.0000000000014989DOI Listing
April 2019
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A History of Innovations in the Diagnosis and Treatment of Oral and Head and Neck Cancer.

J Dent Res 2019 May;98(5):489-497

4 Department of Pathology, University of Chicago, Chicago, IL, USA.

Historical records as far back as 3000 BCE show that oral and head and neck cancer was a disease process well known to Egyptian physicians. Luminaries such as Hippocrates, Galen, Pott, and Virchow were instrumental in shaping our understanding of the etiology and pathogenesis of cancer. During the 20th century, evidence-based medicine catalyzed the development of rigorous science-based diagnostic and treatment protocols. Read More

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http://dx.doi.org/10.1177/0022034519833645DOI Listing
May 2019
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Prevalence and factors associated with unmet needs in post-treatment cancer survivors: A systematic review.

Eur J Cancer Care (Engl) 2019 Apr 22:e13060. Epub 2019 Apr 22.

Department of Family Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Cancer survivors may experience unmet needs beyond the end of their treatment. This paper aimed to explore the prevalence and most frequently found unmet needs and to identify factors associated with higher levels of total unmet needs and with each domain separately. Five databases were searched using the keywords neoplasms, survivors, needs assessment, health services' needs and demands. Read More

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http://dx.doi.org/10.1111/ecc.13060DOI Listing

PRRX-NCOA1/2 Rearrangement Characterizes A Distinctive Fibroblastic Neoplasm.

Genes Chromosomes Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Fibroblastic/myofibroblastic neoplasms represent a broad, and occasionally diagnostically challenging, category of soft tissue neoplasms. A subset of tumors defy conventional classification. However, with the advent of next-generation sequencing, the identification of disease-defining molecular alterations is gradually improving their sub-classification. Read More

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http://dx.doi.org/10.1002/gcc.22762DOI Listing

Majority of -Mutant and -Deficient Colorectal Carcinomas Achieve Clinical Benefit From Immune Checkpoint Inhibitor Therapy and Are Microsatellite Instability-High.

JCO Precis Oncol 2019 4;3. Epub 2019 Mar 4.

Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Microsatellite instability-high (MSI-H) colorectal carcinomas (CRCs) show high rates of response to immune checkpoint inhibitors (IOs). mutations and protein loss have been proposed as causes of resistance to IOs, yet they are enriched in MSI-H CRC. We aimed to characterize -mutant, IO-naive CRC. Read More

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http://dx.doi.org/10.1200/PO.18.00321DOI Listing

Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available.

Case Rep Pathol 2019 17;2019:5103496. Epub 2019 Mar 17.

Servicio de Patología, Hospital Metropolitano, Ecuador.

Secretory carcinoma (SC) is a recently described entity occurring in the salivary glands. Before its description, SC was frequently classified as acinic cell carcinoma (ACC) or adenocarcinoma, not otherwise specified. Its particular histopathological and immunohistochemical characteristics are reminiscent of breast secretory carcinoma. Read More

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http://dx.doi.org/10.1155/2019/5103496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441535PMC

Late-onset osteosarcoma after onychectomy in a cat.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116919842394. Epub 2019 Apr 9.

South Austin Cat Hospital, Austin, TX 78747, USA.

Case Summary: A 12-year-old neutered male onychectomized Ragdoll cat presented for a 3 day history of swelling and hemorrhagic purulent discharge on the first digit of the left manus. Radiographs revealed fragments of the third phalangeal bone (P3) present in the partially amputated digits with swelling adjacent to the P3 fragment on the first digit of the left manus. Thoracic radiographs revealed no evidence of primary or metastatic neoplasia. Read More

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http://dx.doi.org/10.1177/2055116919842394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457030PMC

Dyspnoea and restrictive lung disease due to mediastinal and pleural lipomatosis in morbid obesity.

Respirol Case Rep 2019 Jul 9;7(5):e00421. Epub 2019 Apr 9.

Department of Respiratory Medicine Waikato Hospital Hamilton New Zealand.

Dyspnoea in obese patients can be multifactorial and complex. Mediastinal and pleural lipomatosis can be associated with obesity and is usually considered asymptomatic and benign. We report an obese 39-year-old man who presented with progressive dyspnoea, where in addition to obstructive sleep apnoea and obesity hypoventilation syndrome, was found to have massive mediastinal and pleural lipomatosis causing restrictive lung disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/rcr2.421
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http://dx.doi.org/10.1002/rcr2.421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454808PMC
July 2019
1 Read

Breast diseases in women over the age of 65 in Monastir, Tunisia.

Pan Afr Med J 2018 1;31:67. Epub 2018 Oct 1.

Department of Gynecology and Obstetrics, El Omrane Hospital, Monastir, Tunisia.

As life expectancy is on the rise, it is predicted that a growing number of people will live beyond the age of 65 and therefore a higher number of elderly women will have breast diseases requiring significant health care and services. This study is aimed at investigating the characteristics, the treatment and outcomes of women older than 65 years old treated for breast diseases at our institution. This was a retrospective study covering the period from January 2003 to December 2011. Read More

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http://www.panafrican-med-journal.com/content/article/31/67/
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http://dx.doi.org/10.11604/pamj.2018.31.67.16105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457924PMC
October 2018
1 Read

[Solitary ganglioneuroma of the oropharynx].

Arkh Patol 2019 ;81(2):43-46

Research and Clinical Centre for Otorhinolaryngology, Federal Biomedical Agency of Russia, Moscow, Russia.

Mucosal neuromas, or ganglioneuromas, attract attention as a frequent component of multiple endocrine neoplasia (MEN) syndrome type 2B. The paper describes a clinical and morphological case of solitary oropharyngeal ganglioneuroma in a 60-year-old man, whose observation has not revealed its apparent association with the MEN syndrome. Read More

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http://dx.doi.org/10.17116/patol20198102143DOI Listing
January 2019

[Comparative assessment of the expression of Muc 2, Muc 5AC, and Muc 6 in serrated neoplasms of the colon].

Arkh Patol 2019 ;81(2):10-17

Research Institute of Human Morphology, Moscow, Russia.

In the course of the serrated pathway of carcinogenesis, there are changes in the expression of mucins with a characteristic immunophenotypic sign, such as a late loss of intestinal differentiation and an increase in gastric differentiation.

Objective: To comparatively assess the expression of Muc 2, Muc 5AC, and Muc 6 in hyperplastic polyps (HPs), sessile serrated adenomas (SSAs) and traditional serrated adenomas (TSAs) of the colon for determination of their role in differential diagnosis.

Material And Methods: Sixty-five serrated masses from 52 patients were examined. Read More

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http://dx.doi.org/10.17116/patol20198102110DOI Listing
January 2019
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Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: A propensity score-matched study.

Asian J Androl 2019 Apr 19. Epub 2019 Apr 19.

Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.

This study compared the diagnostic efficacy of transrectal ultrasound (TRUS)-guided prostate biopsy (TRBx) and transperineal prostate biopsy (TPBx) in patients with suspected prostate cancer (PCa). We enrolled 2962 men who underwent transrectal (n = 1216) or transperineal (n = 1746) systematic 12-core prostate biopsy. Clinical data including age, prostate-specific antigen (PSA) level, and prostate volume (PV) were recorded. Read More

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http://dx.doi.org/10.4103/aja.aja_16_19DOI Listing

Methylation of tumour suppressor genes associated with thyroid cancer.

Cancer Biomark 2019 Apr 8. Epub 2019 Apr 8.

National Institute for Chemical pharmaceutical Research and Development, Calea Vitan, Romania.

Background: Thyroid carcinoma is the most common endocrine malignancy worldwide. Changes in DNA methylation can cause silencing of normally active genes, especially tumour suppressor genes (TSG) or activation of normally silent genes.

Objective: The aim of this study is to evaluate the degree of promoter methylation for a panel of markers for thyroid neoplasms and to establish their relationship with thyroid oncogenesis. Read More

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http://dx.doi.org/10.3233/CBM-182265DOI Listing

Submental island flap versus radial forearm free flap for oral tongue reconstruction: a comparison of complications and functional outcomes.

J Laryngol Otol 2019 Apr 22:1-6. Epub 2019 Apr 22.

Otolaryngology Unit,Phayao Hospital,Thailand.

Objective: This study compared the complications and functional outcomes of patients with oral tongue cancer who had undergone reconstruction using a submental island flap or a radial forearm free flap.

Method: Of the 54 patients, 29 underwent reconstruction with a submental island flap and 25 patients with a radial forearm free flap. The complications and outcomes of speech and swallowing were evaluated. Read More

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http://dx.doi.org/10.1017/S0022215119000744DOI Listing

The fractal dimension of chromatin - a potential molecular marker for carcinogenesis, tumor progression and prognosis.

Expert Rev Mol Diagn 2019 Apr;19(4):299-312

b Department of Applied Mathematics , Institute of Mathematics, Statistics and Scientific Computing, State University of Campinas , Campinas , Brazil.

Introduction: Fractality is omnipresent in medicine and life sciences. In particular, the fractal principle is found simultaneously at different organization levels of the cell nucleus. The aim of this review is to show whether fractal characteristics of chromatin could be related to tumor pathology and pathophysiology. Read More

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http://dx.doi.org/10.1080/14737159.2019.1597707DOI Listing

Cecal Mucosal Myxoma: The First Report of a New Type of Mesenchymal Colon Polyp.

Int J Surg Pathol 2019 Apr 22:1066896919843625. Epub 2019 Apr 22.

1 University of Rochester, Rochester, NY, USA.

Myxomas are benign mesenchymal neoplasms of unknown etiology that most commonly occur in the cardiac atrium; however, other reported sites include the skin, joints, skeletal muscles, maxillofacial bones, and sinonasal tract. Myxomas involving the gastrointestinal (GI) tract are rare and are limited to a few published case reports. We are presenting, to our knowledge, the first case report of a mucosal myxoma in the colon presenting as a colonic polyp. Read More

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http://dx.doi.org/10.1177/1066896919843625DOI Listing

Octreotide-conjugated Core Cross-linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance.

ACS Appl Mater Interfaces 2019 Apr 22. Epub 2019 Apr 22.

The study of multifunctional polymer micelles combined with chemotherapy due to reduced systemic toxicity and enhanced efficacy has attracted intensive attention. Herein, a multifunctional core cross-linked hybrid micelle system based on mPEG-b-PGu(BA-TPE) and OCT-PEG-b-PGu(DA-TPE) with pH- and redox-triggered drug release and aggregation-induced emission (AIE) active imaging has been developed for active targeting of neuroendocrine neoplasms (NENs), especially neuroendocrine carcinomas (NECs) with poor prognosis. These micelles showed excellent biocompatibility and stability. Read More

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http://dx.doi.org/10.1021/acsami.9b01827DOI Listing

[Safety and efficacy of transarterial embolization combined with octreotide LAR on reducing tumor burden for neuroendocrine tumor liver metastasis].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(15):1142-1146

Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To evaluate the tumor burden reducing efficacy and safety of transcatheter arterial embolization (TAE) combined with octreotide LAR on neuroendocrine tumor liver metastasis (NETLM). Twenty-nine NETLM patients treated in the First Affiliated Hospital of Sun Yat-sen University from October 2014 to August 2018 were retrospectively recruited, including 12 males and 17 females. The mean age was 25-69(50±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.15.005DOI Listing

[Association between the frequency of bowel movements and the risk of colorectal cancer in Chinese adults].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Apr;40(4):382-388

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

To examine the association between the frequencies of bowel movement (BMF) and the risk of colorectal cancer (CRC). In this study, 510 134 participants from the China Kadoorie Biobank (CKB) were included, after excluding those who reported as having been diagnosed with cancer at the baseline survey. The baseline survey was conducted from June 2004 to July 2008. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.04.003DOI Listing

[Role and mechanism of the regulation of nuclear factor-κB by heparin binding-epidermal growth factor-like growth factor in the induction of paclitaxel resistance of ovarian cancer].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):255-261

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

To investigate the role and mechanism of the regulation of nuclear factor-κB (NF-κB) by heparin binding-epidermal growth factor-like growth factor (HB-EGF) in paclitaxel resistance of ovarian cancer in vitro and in vivo. (1) The detection of NF-κB expression: parental (A2780) and paclitaxel-resistant (A2780/Taxol) ovarian carcinoma cells were divided into four groups, named A2780 group, A2780+cross-reacting material 197 (CRM197, HB-EGF inhibitor) group, A2780/Taxol group and A2780/Taxol+CRM197 group. Among four groups, the expression level HB-EGF and epidermal growth factor receptor (EGFR) were examined by immunofluorescence double staining on confocal microscopy. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.008DOI Listing

[Effects of metformin on the expression of estrogen synthetase and ER mRNA in uterine leiomyoma tissues].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):249-254

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China.

To elucidate whether metformin could regulate the mRNA expression level of estrogen synthetase and ER in human uterine leiomyoma tissues. (1) Seventeen pairs of uterine leiomyoma tissues and adjacent myometrium (>2 cm) were collected from patients underwent hysterectomy in Peking University First Hospital between December 2016 and January 2017. Real-time PCR was used to measure the mRNA expression level of estrogen synthetase [including cytochrome P450 cholesterol side chain cleavage enzyme (P450scc), cytochrome P450 17α-hydroxylase (P450c17), 3-beta-hydroxysteroid dehydrogenase type 2 (3β-HSD-2), 17-beta-hydroxysteroid dehydrogenase type 1 (17β-HSD-1) and aromatase cytochrome P450 (P450arom)] and ER (including ERα and ERβ) in the uterine leiomyoma tissues and adjacent myometrium. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.007DOI Listing

Accuracy of mortality statistics in Palestine: a retrospective cohort study.

BMJ Open 2019 Apr 20;9(4):e026640. Epub 2019 Apr 20.

Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.

Objective: To examine the accuracy of mortality statistics in Palestine, to identify gaps and to provide evidence-based recommendations to improve mortality statistics in Palestine.

Study Design And Setting: A retrospective death registry-based study that examined a stratified random sample of death notification forms (DNFs) of patients who died in hospitals in Palestine was reported in 2012. We randomly selected 600 deceased from the Cause of Death Registry: 400 from the West Bank and 200 from the Gaza Strip. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02664
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http://dx.doi.org/10.1136/bmjopen-2018-026640DOI Listing
April 2019
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Comparative evaluation of novel screening strategies for colorectal cancer screening in China (TARGET-C): a study protocol for a multicentre randomised controlled trial.

BMJ Open 2019 Apr 20;9(4):e025935. Epub 2019 Apr 20.

Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Introduction: Screening for colorectal cancer (CRC) is effective in reducing the disease burden. However, high-level evidence from randomised controlled trials on the effectiveness of CRC screening modalities is still lacking. We will conduct a large-scale multicentre randomised controlled trial in China to evaluate the effectiveness and cost-effectiveness of different CRC screening strategies. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025935DOI Listing

Primary cardiac epithelioid angiosarcoma with frond-like features: a rare and ominous radiological mimicker of benign cardiac tumors.

Cardiovasc Pathol 2019 Apr 8;41:18-20. Epub 2019 Apr 8.

Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

Most primary cardiac tumors are benign neoplasms, which generally can be differentiated from malignant neoplasms via certain radiological features. We present briefly a case of a 26-year-old man undergoing resection of a right atrial mass that based on preceding radiologic findings represent a myxoma. After pathologic examination, the lesion was determined to be an epithelioid angiosarcoma with unique frond-like architecture and multiple pedicular attachments to the atrial wall. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.04.001DOI Listing

Downstream Studies Following the Use of Bone Scan in the Staging of Muscle-invasive Bladder Cancer.

Urology 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA; Center for Research on Health Care, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Objective: To quantify the use of downstream studies following staging bone scans in patients with muscle-invasive bladder cancer. Bone scans may be obtained in high-risk bladder cancer patients prior to radical cystectomy to exclude bone metastases. However, false positive bone scans can occur, resulting in the need for additional studies. Read More

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http://dx.doi.org/10.1016/j.urology.2019.04.009DOI Listing
April 2019
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Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas.

Neoplasia 2019 Apr 18;21(6):505-515. Epub 2019 Apr 18.

Falk Brain Tumor Center and Division of Pediatric Neurosurgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Development Biology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Background: Ependymomas (EPNs) are the third most common brain tumor in children. These tumors are resistant to available chemotherapeutic treatments, therefore new effective targeted therapeutics must be identified. Increasing evidence shows epigenetic alterations including histone posttranslational modifications (PTMs), are associated with malignancy, chemotherapeutic resistance and prognosis for pediatric EPNs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14765586193007
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http://dx.doi.org/10.1016/j.neo.2019.03.012DOI Listing
April 2019
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Head and neck carcinoma of unknown primary.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 17. Epub 2019 Apr 17.

Département d'orl et chirurgie cervico faciale, hôpital universitaire Gui de Chauliac, université de Montpellier, CHRU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.

In adult cervicofacial pathology, carcinoma of unknown primary is defined as lymph-node metastasis the anatomic origin of which is not known at the time of initial management. It constitutes up to 5% of head and neck cancers. Presentation may suggest benign pathology, delaying and confusing oncologic treatment. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.002DOI Listing

Prevalence of odontogenic cysts and tumors associated with impacted third molars: A systematic review and meta-analysis.

J Craniomaxillofac Surg 2019 Mar 30. Epub 2019 Mar 30.

Department of Pathology, Federal University of Santa Catarina, Florianópolis, Brazil. Electronic address:

Purpose: This systematic review aimed to investigate the prevalence of odontogenic cysts and tumors associated with impacted third molars (ITM).

Methods: Only studies that performed histopathological diagnosis of lesions were eligible for inclusion. Five main electronic and three grey literature databases were searched. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.03.026DOI Listing

Preadmission chronic opioid usage and its association with 90-day mortality in critically ill patients: a retrospective cohort study.

Br J Anaesth 2019 Apr 18. Epub 2019 Apr 18.

Department of Biostatistics, College of Medicine, Korea University, Seoul, South Korea.

Background: The aim of this study was to investigate the association of chronic opioid usage with 90-day mortality in critically ill patients after admission to the ICU.

Methods: This retrospective cohort study analysed the medical records of adult patients admitted to ICUs in a tertiary academic hospital between January 2012 and December 2017. Patients taking opioids regularly for more than 4 weeks before ICU admission were defined as chronic opioid users, whereas the others were defined as opioid-naïve patients. Read More

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http://dx.doi.org/10.1016/j.bja.2019.03.032DOI Listing
April 2019
1 Read

Does higher field strength translate into better diagnostic accuracy? A prospective comparison of breast MRI at 3 and 1.5 Tesla.

Eur J Radiol 2019 May 28;114:51-56. Epub 2019 Feb 28.

Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Waehringer-Guertel 18-20, Vienna, Austria. Electronic address:

Objective: We performed a prospective monocentric study to inter-individually compare the diagnostic accuracy of breast MRI at 1.5 T and 3 T.

Methods: During a consecutive period of 12 months all 982 patients receiving breast MRI according to standard indications (problem solving, preoperative staging) were randomized to one 3 T or 1. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.02.033DOI Listing

Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
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Meningioma originating from the hypoglossal canal: Case report and review of literature.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Sapporo Medical University School of Medicine.

Primary extracranial meningiomas are uncommon neoplasms. In particular, meningioma involving the hypoglossal canal is extremely rare, with only four cases reported in the literature so far. As each of these meningiomas originated in the juxta-condyle region with involving the hypoglossal canal, to the best of our knowledge, a meningioma which exists only within hypoglossal canal has yet to be reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193107
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http://dx.doi.org/10.1016/j.wneu.2019.04.084DOI Listing
April 2019
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MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma.

Hum Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization (DISH) for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.04.002DOI Listing

Determine safety of outpatient chemotherapy and autotransplants using refrigerated, non-frozen grafts in persons with multiple sclerosis.

Clin Transplant 2019 Apr 20:e13567. Epub 2019 Apr 20.

Centro de Hematología y Medicina Interna de Puebla, Puebla, México.

Persons with multiple sclerosis (MS) are sometimes treated with intermediate- or high-dose chemotherapy and an autotransplant (1, 2). More than 1000 autotransplants are reported with MS (2-6) but use of autotransplants may be substantially more common as many cases are not reported. Recent data from a small randomized trial of less-intensive chemotherapy reported better outcomes with this approach compared with disease-modifying therapy in persons with advanced relapsing-remitting MS (7). Read More

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http://dx.doi.org/10.1111/ctr.13567DOI Listing

Prostate Specific Antigen Nadir After Radical Cystoprostatectomy in Patients With Benign Prostatic Tissue: A Benchmark To Define Biochemical Recurrence after Radical Prostatectomy.

Urol J 2019 Apr 20. Epub 2019 Apr 20.

Department of Urology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Purpose: Biochemical failure after radical prostatectomy has been defined based on retrospective studies in men who underwent RP for localized prostate cancer. Nevertheless, retrospective strategy and possibility of extra-prostatic extension overshadowed the accurateness of the aforementioned cut-off value. To define a more precise PSA nadir value, we estimated serum PSA after cystoprostatectomy in cases with bladder urothelial cancer and no evidence of prostate cancer. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4551DOI Listing
April 2019
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Lung cancer survival and comorbidities in lung cancer screening participants of the Gdańsk screening cohort.

Eur J Public Health 2019 Apr 19. Epub 2019 Apr 19.

Department of Thoracic Surgery, Medical University of Gdańsk, Gdańsk, Poland.

Background: In 2010, the World Health Organisation recommended implementation of screening programmes in four groups of diseases-neoplasms, cardiovascular diseases (CVD), diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD). It is due to the fact that they share the same, modifiable risk factors.

Methods: Between 2009 and 2011, 8637 heavy smokers (aged 50-75, smoking history >20 pack-years) were screened in the Pomeranian Pilot Lung Cancer Screening Programme (PPP) in Gdańsk, Poland. Read More

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http://dx.doi.org/10.1093/eurpub/ckz052DOI Listing

Increased HPV detection by the use of a pre-heating step on vaginal self-samples analysed by Aptima HPV assay.

J Virol Methods 2019 Apr 16. Epub 2019 Apr 16.

Department of Medical Microbiology, Laboratory Medicine Region Skåne, Lund University, Lund, Sweden. Electronic address:

Background: We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV).

Objectives: To increase detection of HPV among self-samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934193011
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http://dx.doi.org/10.1016/j.jviromet.2019.04.015DOI Listing
April 2019
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Current Knowledge of Ipilimumab and its use in Treating Non-small Cell Lung cancer.

Expert Opin Biol Ther 2019 Apr 19. Epub 2019 Apr 19.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore , MD , USA.

Introduction: The systemic treatment of non-small cell lung cancer (NSCLC) has changed dramatically with the identification of actionable mutations and the use of targeted agents. Unfortunately, many tumors will acquire resistance and >75% of NSCLC cases lack for an actionable gene aberration. In this setting, immunotherapy rises as effective therapeutic where immune checkpoint inhibitors have entered or are entering the market in many neoplasms, including NSCLC. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1610380DOI Listing
April 2019
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Work adjustments and employment among breast cancer survivors: a French prospective study.

Support Care Cancer 2019 Apr 17. Epub 2019 Apr 17.

Service des Maladies Professionnelles et Environnementales, CHU Toulouse, F-31000, Toulouse, France.

Purpose: The objective of our study was to assess the rate of work adjustments 1 year after the diagnosis in a population of female breast cancer (BC) survivors, in the context of the French system of social protection. We also characterised these adjustments and their influence on the reduction of professional exclusion of patients 1 year after the diagnosis.

Methods: This observational, prospective study was conducted from February 2015 to April 2016 among female patients with BC. Read More

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http://dx.doi.org/10.1007/s00520-019-04799-wDOI Listing

Suggested Indications for Enucleation of Solid Pseudopapillary Neoplasms in Pediatric Patients.

Front Pediatr 2019 3;7:125. Epub 2019 Apr 3.

Department of Pediatric Surgery, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea.

Solid pseudopapillary neoplasms (SPNs) are rare, low-grade, malignant neoplasms that can occur in pediatric patients. Although complete resection of the tumor is the principle treatment, SPN enucleation (EN) has been reported to be effective in children. This study aimed to examine the feasibility and safety of EN by comparing it with conventional pancreatectomy (CP), and to present the indications for its use in pediatric patients. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00125/
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http://dx.doi.org/10.3389/fped.2019.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456698PMC
April 2019
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Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients.

Front Oncol 2019 3;9:213. Epub 2019 Apr 3.

Human Histology and Embryology Unit, University of Verona Medical School, Verona, Italy.

High oncogenic risk human papillomaviruses (HR-HPVs) promote cervical carcinoma development, the fourth most common feminine cancer. A slow oncodevelopmental phase-defined histopathologically as Cervical Intraepithelial Neoplasia (CIN) grades 1-3, or cytologically as Low- or High-grade Squamous Intraepithelial Lesions (LSIL or HSIL)-precedes the malignancy. Cervical carcinoma screenings through HR-HPV genotyping and Pap smears are regularly performed in Western countries. Read More

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http://dx.doi.org/10.3389/fonc.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456695PMC

Performance of Different Combination Models of High-Risk HPV Genotyping in Triaging Chinese Women With Atypical Squamous Cells of Undetermined Significance.

Front Oncol 2019 3;9:202. Epub 2019 Apr 3.

Department of Cancer Epidemiology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.

The purpose of this study was to evaluate the effect of different combination models of high-risk human papilloma viruses (HPV) genotyping in triaging Chinese women with atypical squamous cells of undetermined significance (ASCUS). We established a screening cohort of 3,997 Chinese women who underwent cervical cytology and HPV genotyping test. Women with ASCUS cytology underwent punch biopsy under colposcopy/endocervical curettage. Read More

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http://dx.doi.org/10.3389/fonc.2019.00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456653PMC
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