31,618 results match your criteria Neonatology Today[Journal]


Carbon dioxide diffusion coefficient in noninvasive high-frequency oscillatory ventilation.

Pediatr Pulmonol 2019 Apr 17. Epub 2019 Apr 17.

Division of Neonatology, Center for Pediatrics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objectives: The carbon dioxide (CO ) diffusion coefficient (DCO ) reflects CO removal during high-frequency oscillatory ventilation (HFOV). We hypothesized that despite leak flow during noninvasive HFOV (nHFOV) DCO continues to indicate ventilation efficacy.

Methods: A neonatal airway model including CO production and an adjustable oropharyngeal leak was connected to a ventilator via bi-nasal prongs. Read More

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http://dx.doi.org/10.1002/ppul.24333DOI Listing

Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity.

BMJ Open Ophthalmol 2019 27;4(1):e000211. Epub 2019 Feb 27.

Pediatric, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

Objective: Retinopathy of prematurity (ROP) is a major cause of blindness in newborn infants, which also occurs in low-income and middle-income countries. Why ROP progresses in some infants while it regresses in others is still presently unknown. Studies suggest that genetic factors might be involved. Read More

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http://dx.doi.org/10.1136/bmjophth-2018-000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440590PMC
February 2019

Retrospective analysis of iatrogenic diseases in cattle requiring admission to a veterinary hospital.

Vet Rec Open 2019 18;6(1):e000254. Epub 2019 Feb 18.

Dipartimento di Medicina Veterinaria, Universita degli Studi di Milano, Lodi, Italy.

Iatrogenic diseases in veterinary medicine are often related to malpractice or lack of skill. For this retrospective study, 4262 clinical records of cattle admitted to the veterinary teaching hospital of the University of Milan between 2005 and 2017 were analysed, and 121 cases (2.8 per cent), referred for an iatrogenic-related disease, were selected. Read More

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http://dx.doi.org/10.1136/vetreco-2017-000254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446213PMC
February 2019

Dextrose gels for neonatal transitional hypoglycemia: What are we giving our babies?

Paediatr Child Health 2019 May 5;24(2):115-118. Epub 2019 Feb 5.

Division of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia.

Transitional hypoglycemia is common in at-risk newborns, frequently resulting in therapeutic interference with bonding and breastfeeding; 40% dextrose gel massaged to the buccal mucosa has been shown to decrease hypoglycemia <2.6 mmol/L and NICU admissions. However, in the absence of a newborn-specific product, over-the-counter diabetes-care products with poorly documented composition are being used for neonates. Read More

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http://dx.doi.org/10.1093/pch/pxy185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462133PMC

Split frenulum: Nonaccidental trauma or frenotomy?

Paediatr Child Health 2019 May 24;24(2):72-73. Epub 2018 Jul 24.

Sheldon Kennedy Child Advocacy Centre, Calgary, Alberta.

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http://dx.doi.org/10.1093/pch/pxy087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462128PMC

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
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Predictors of severe intraventricular hemorrhage in preterm infants under 29-weeks gestation.

J Matern Fetal Neonatal Med 2019 Apr 17:1-6. Epub 2019 Apr 17.

d Division of Neonatology , Department of Pediatrics, University of Minnesota , Minneapolis , MN , USA.

Purpose: Preterm infants <29 weeks of gestation are at risk for severe intraventricular hemorrhage (IVH). Lower gestational age, birth weight, severe illness, as indexed by higher Score for Neonatal Acute Physiology - Perinatal Extension II (SNAPPE-II) are associated with severe IVH. The role of coagulation abnormalities on the first day after birth in severe IVH remains controversial. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601698DOI Listing

Association between neonatal serum bilirubin and childhood obesity in preterm infants.

Pediatr Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Neonatology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.

Background: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants.

Methods: Data were obtained from the US Collaborative Perinatal Project. Read More

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http://www.nature.com/articles/s41390-019-0399-3
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http://dx.doi.org/10.1038/s41390-019-0399-3DOI Listing
April 2019
2 Reads

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

Murdoch Childrens Research Institute, 34361, Neonatal Research, Parkville, Victoria, Australia.

To characterize time-dependent and regionally-specific injury patterns associated with early ventilation of the preterm lung using a mass-spectrometry based proteomic approach. Preterm lambs delivered at gestational age 124-127d were randomized to receive 15-min (n=7) or 90-min (n=10) of mechanical ventilation at standardized settings (positive end-expiratory pressure 8 cmHO, tidal volume 6-8 mL/kg) and were compared with unventilated control lambs (n=7). At study completion, lung tissue was taken from standardized gravity-dependent and non-dependent regions, and assessed for lung injury via histology, qPCR and by proteomic analysis via Orbitrap-mass spectrometry. Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2019-0084OC
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http://dx.doi.org/10.1165/rcmb.2019-0084OCDOI Listing
April 2019
1 Read

The Diagnosis of Bronchopulmonary Dysplasia in Very Preterm Infants: An Evidence-Based Approach.

Am J Respir Crit Care Med 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Division of Neonatology, Philadelphia, Pennsylvania, United States.

Rationale: Current diagnostic criteria for bronchopulmonary dysplasia rely heavily on the level and duration of oxygen therapy, do not reflect contemporary neonatal care, nor adequately predict childhood morbidity.

Objective: To determine which of 18 pre-specified, revised definitions of bronchopulmonary dysplasia, that variably define disease presence and severity according to the level of respiratory support and supplemental oxygen administered at 36 weeks postmenstrual age, best predicts death or serious respiratory morbidity through 18-26 months corrected age.

Methods: We assessed infants born <32 weeks' gestation between 2011-2015 at 18 centers of the National Institute of Child Health and Human Development Neonatal Research Network. Read More

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https://www.atsjournals.org/doi/10.1164/rccm.201812-2348OC
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http://dx.doi.org/10.1164/rccm.201812-2348OCDOI Listing
April 2019
1 Read

Missense changes in the catalytic domain of coagulation factor X account for minimal function preventing a perinatal lethal condition.

Haemophilia 2019 Apr 17. Epub 2019 Apr 17.

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

Introduction: Inherited deficiencies in the coagulation pathway provide diversified models to investigate the molecular bases of perinatal lethality associated with null-like variants. Differently from X-linked haemophilias, homozygous/doubly heterozygous null variants in the rare autosomally inherited deficiency of factor X (FX) might be incompatible with perinatal survival.

Aim: To provide experimental evidence about the null/close-to-null FX function. Read More

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http://dx.doi.org/10.1111/hae.13761DOI Listing

Comparison of dermal versus internal light administration in human lungs using the TDLAS-GASMAS technique - Phantom studies.

J Biophotonics 2019 Apr 16:e201800350. Epub 2019 Apr 16.

Lund Laser Centre, Lund University, Lund, Sweden.

Oxygen and water vapor content, in the lungs of a 3D-printed phantom model based on CT-images of a preterm infant, is evaluated using Tunable Diode Laser Absorption Spectroscopy (TDLAS) in Gas in Scattering Media Absorption Spectroscopy (GASMAS), i.e. the TDLAS-GASMAS technique. Read More

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http://dx.doi.org/10.1002/jbio.201800350DOI Listing

HbA1c and retinal arteriolar narrowing in children with type 1 diabetes: the DEAR-Kids study.

Pediatr Diabetes 2019 Apr 16. Epub 2019 Apr 16.

Department of General Paediatrics, Adolescent Medicine and Neonatology, Medical Centre, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background/objective: Microvascular alterations play a key role in the development of diabetes complications. Retinal vessel analysis is a unique method to examine microvascular changes in brain derived vessels.

Subjects/methods: 67 pediatric and adolescent type 1 diabetes patients and 58 healthy control persons (mean age 12. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12858
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http://dx.doi.org/10.1111/pedi.12858DOI Listing
April 2019
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Serum high mobility group box-1 and cytokine profiles in a leukemoid reaction.

Pediatr Int 2019 Apr 17. Epub 2019 Apr 17.

Shino-Test Corporation, Sagamihara, Kanagawa, Japan.

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http://dx.doi.org/10.1111/ped.13797DOI Listing

Risk factors for recurrent macrosomia and child outcomes.

World J Pediatr 2019 Apr 16. Epub 2019 Apr 16.

Shanghai Key Laboratory of Female Reproductive Endocrine Related Disease, Obstetrics and Gynecology Hospital of Fudan University, 128 Shen Yang Road, Shanghai, 200092, China.

Background: Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health.

Methods: Data from the Collaborative Perinatal Project, a longitudinal birth cohort with 54,371 singleton births, were used. Read More

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http://link.springer.com/10.1007/s12519-019-00249-z
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http://dx.doi.org/10.1007/s12519-019-00249-zDOI Listing
April 2019
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The Prevalence of Complications of Prematurity among 1000 Newborns in Isfahan, Iran.

Adv Biomed Res 2019 21;8:12. Epub 2019 Feb 21.

Department of Epidemiology and Biostatistics, Health School, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Different morbidity conditions are globally reported from different nations for premature infants. The aim of this study was to identify the relative frequency of some of the most important complications of prematurity in a population of about 1000 of very low birth weight (VLBW; i.e. Read More

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http://www.advbiores.net/text.asp?2019/8/1/12/252652
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http://dx.doi.org/10.4103/abr.abr_84_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425744PMC
February 2019
1 Read

Alternatives to systemic postnatal corticosteroids: Inhaled, nebulized and intratracheal.

Semin Fetal Neonatal Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Neonatology, University Hospital and University of Zürich, Zürich, Switzerland.

Concern about adverse outcomes with the use of systemic postnatal corticosteroids (PCS) for bronchopulmonary dysplasia (BPD) have led to the widespread use of alternative methods of administration in research and clinical care. Theoretically, administration of topical (directly to the lung) corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable side effects compared with systemic administration. Current evidence suggests that inhaled corticosteroids may be an effective therapy in the management of developing BPD in preterm infants, but questions about their safety remain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1744165X193003
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http://dx.doi.org/10.1016/j.siny.2019.04.006DOI Listing
April 2019
1 Read

Health-related quality of life as an endpoint in oncology phase I trials: a systematic review.

BMC Cancer 2019 Apr 16;19(1):361. Epub 2019 Apr 16.

Methodology and Quality of Life in Oncology Unit, INSERM UMR 1098, University Hospital of Besançon, Besançon, France.

Background: Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of this study is to review the phase I in oncology which used HRQoL as endpoint. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5579-3DOI Listing
April 2019
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Network based statistics reveals trophic and neuroprotective effect of early high dose erythropoetin on brain connectivity in very preterm infants.

Neuroimage Clin 2019 Apr 1;22:101806. Epub 2019 Apr 1.

Department of Neonatology, University Hospital Zurich, Zurich, Switzerland; Department of Neonatology and Pediatric Intensive Care, University Children's Hospital Zurich, Zurich, Switzerland.

Periventricular white matter injury is common in very preterm infants and it is associated with long term neurodevelopmental impairments. While evidence supports the protective effects of erythropoetin (EPO) in preventing injury, we currently lack the complete understanding of how EPO affects the emergence and maturation of anatomical brain connectivity and function. In this case-control study, connectomic analysis based on diffusion MRI tractography was applied to evaluate the effect of early high-dose EPO in preterm infants. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101806DOI Listing

SENTINEL1: Two-Season Study of Respiratory Syncytial Virus Hospitalizations among U.S. Infants Born at 29 to 35 Weeks' Gestational Age Not Receiving Immunoprophylaxis.

Am J Perinatol 2019 Apr 16. Epub 2019 Apr 16.

AstraZeneca, Gaithersburg, Maryland.

Objective:  The SENTINEL1 observational study characterized confirmed respiratory syncytial virus hospitalizations (RSVH) among U.S. preterm infants born at 29 to 35 weeks' gestational age (wGA) not receiving respiratory syncytial virus (RSV) immunoprophylaxis (IP) during the 2014 to 2015 and 2015 to 2016 RSV seasons. Read More

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http://dx.doi.org/10.1055/s-0039-1681014DOI Listing
April 2019
5 Reads

Neurodevelopmental outcomes of extremely preterm infants in southern China: A multicenter study.

Early Hum Dev 2019 Apr 13;133:5-10. Epub 2019 Apr 13.

Department of Neonatology, The First People's Hospital of Hechi, Hechi, Guangxi, China.

Objective: To assess treatment outcomes and associated factors of extremely preterm infants (EPIs) in GuangXi, China.

Methods: This was a retrospective study consisting of 131 eligible cases with gestational age (GA) between 22 and 28 weeks, and infants were followed until 18-24 months. Data including clinical characteristics, perinatal factors and after-birth conditions were collected from the neonatal intensive care unit in 10 hospitals in Guangxi from January 1st 2010 until May 31st 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183026
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http://dx.doi.org/10.1016/j.earlhumdev.2019.04.002DOI Listing
April 2019
1 Read

Does nuchal cord at birth increase the risk for cerebral palsy?

Early Hum Dev 2019 Apr 13;133:1-4. Epub 2019 Apr 13.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Nuchal cord is a common finding in pregnancy. It is unclear whether a nuchal cord at birth causes birth asphyxia and raises the risk for developing cerebral palsy of the offspring.

Aim: To evaluate the incidence of cerebral palsy in children born with and without nuchal cord. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.04.006DOI Listing

A pilot case-control study of urine metabolomics in preterm neonates with necrotizing enterocolitis.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 8;1117:10-21. Epub 2019 Apr 8.

1(st) Department of Neonatology, School of Medicine, Aristotle University of Thessaloniki, Greece; Biomic_AUTh, Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Balkan Center, B1.4, Thessaloniki, 10th km Thessaloniki-Thermi Rd, P.O. Box 8318, 57001, Greece. Electronic address:

Necrotizing enterocolitis (NEC) is a leading cause of gastrointestinal morbidity and mortality in preterm neonates. The aim of this pilot study was to explore using metabolomics alternations in the urine metabolites related to NEC that could possibly serve as diagnostic biomarkers of the disease. Urine samples were prospectively collected at the day of initial evaluation for NEC from 15 diseased preterm neonates (five Bell's stage I and ten stage II/III) and an equal number of matched controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232193008
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http://dx.doi.org/10.1016/j.jchromb.2019.04.019DOI Listing
April 2019
1 Read

Lactation Experience of Mothers and Feeding Outcomes of Infants with Congenital Diaphragmatic Hernia.

Breastfeed Med 2019 Apr 16. Epub 2019 Apr 16.

5 Department of Neonatology, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Objective: This study explores the congenital diaphragmatic hernia (CDH) infant-mother dyad with regard to maternal lactation outcomes and infant exposure to a human milk diet.

Study Design: This was a retrospective descriptive cohort study conducted at Children's Hospital of Philadelphia. A total of 149 infants born with CDH and admitted to the Newborn/Infant Intensive Care Unit (N/IICU) were included in the study. Read More

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http://dx.doi.org/10.1089/bfm.2019.0011DOI Listing

Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies.

Neurophotonics 2019 Apr 3;6(2):025001. Epub 2019 Apr 3.

University of Zurich and ETH Zurich, Institute for Biomedical Engineering, Zurich, Switzerland.

Multimodal imaging combining optoacoustic tomography (OAT) with magnetic resonance imaging (MRI) enables spatiotemporal resolution complementarity, improves accurate quantification, and thus yields more insights into physiology and pathophysiology. However, only manual landmark based coregistration of OAT-MRI has been used so far. We developed a toolbox (RegOA), which frames an automated registration pipeline to align OAT with high-field MR images based on mutual information. Read More

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http://dx.doi.org/10.1117/1.NPh.6.2.025001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446211PMC

Protective role of phenylethanoid glycosides, Torenoside B and Savatiside A, in Alzheimer's disease.

Exp Ther Med 2019 May 7;17(5):3755-3767. Epub 2019 Mar 7.

College of Pharmaceutical Science, Soochow University, Suzhou, Jiangsu 215000, P.R. China.

The current study assessed the efficacy of two phenylethanoid glycosides (PhGs), Torenoside B (TB) and Savatiside A (SA), in the treatment of Alzheimer's disease (AD). The effects of TB and SA compounds were first assessed following amyloid beta (Aβ) induction in SH-SY5Y cells at a range of concentrations. Their effects on cell viability and reactive oxygen species (ROS) were determined by performing MTT and dichlorofluorescin diacetate assays, respectively. Read More

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http://dx.doi.org/10.3892/etm.2019.7355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447766PMC
May 2019
1 Read

Maternal breast milk feeding and length of treatment in infants with neonatal abstinence syndrome.

J Perinatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Neonatology, Thomas Jefferson University Hospital/Nemours, Philadelphia, PA, USA.

Objective: The objective of this study is to assess whether infants with neonatal abstinence syndrome (NAS), who receive maternal breast milk (BM), have shorter pharmacological treatment durations and lengths of stay compared with formula-fed infants.

Study Design: Retrospective data analysis from Optum Neonatal Database for infants born between 1 January 2010 and 21 November 2016, who received treatment for NAS. Clinical characteristics and outcomes were compared between infants who received any amount of BM and those exclusively formula-fed. Read More

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http://dx.doi.org/10.1038/s41372-019-0374-1DOI Listing

An Analysis of Time to Improvement in Oxygenation in Japanese Preterm and Late Preterm or Term Neonates With Hypoxic Respiratory Failure and Pulmonary Hypertension.

Clin Ther 2019 Apr 12. Epub 2019 Apr 12.

Nagoya City West Medical Center, Nagoya, Japan.

Purpose: We analyzed data from an ongoing registry to determine time to improvement in oxygenation in preterm and late preterm or term neonates with hypoxic respiratory failure and pulmonary hypertension receiving inhaled nitric oxide (iNO) in Japan.

Methods: Registry neonates received iNO ≤7 days after birth (February 26, 2010, to October 9, 2012). Efficacy and safety profile data were collected up to 96 h after iNO initiation and, if necessary, every 24 h thereafter and before iNO discontinuation. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.03.008DOI Listing

Occupational Therapy Management Strategies for Infants With Neonatal Abstinence Syndrome: Scoping Review.

Occup Ther Health Care 2019 Apr 16:1-30. Epub 2019 Apr 16.

b Department of Pediatrics/Neonatology , Queen's University , Kingston , ON , Canada.

With opioid use in North America rising, there is a growing incidence of neonatal abstinence syndrome (NAS). Infants with NAS experience withdrawal signs that interfere with their occupational performance in activities of daily living. This scoping review aims to identify the non-pharmacologic interventions currently used in the treatment of infants with NAS that fall within the scope of the occupational therapy profession. Read More

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http://dx.doi.org/10.1080/07380577.2019.1594485DOI Listing

Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure.

Medicina (Kaunas) 2019 Apr 4;55(4). Epub 2019 Apr 4.

Second Pediatric Clinic, Department of Mother and Child, University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca, 400012 Cluj-Napoca, Romania.

Classic galactosemia is an autosomal recessive disorder caused by the deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) involved in galactose metabolism. Bacterial infections are a known cause of early morbidity and mortality in children with classic galactosemia. The most common agent is but in rare situations, other bacteria are incriminated. Read More

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http://dx.doi.org/10.3390/medicina55040091DOI Listing

Progressive Immunodeficiency with Gradual Depletion of B and CD4⁺ T Cells in Immunodeficiency, Centromeric Instability and Facial Anomalies Syndrome 2 (ICF2).

Diseases 2019 Apr 4;7(2). Epub 2019 Apr 4.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.

Immunodeficiency, centromeric instability and facial anomalies syndrome 2 (ICF2) is a rare autosomal recessive primary immunodeficiency disorder. So far, 27 patients have been reported. Here, we present three siblings with ICF2 due to a homozygous ZBTB24 gene mutation (c. Read More

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http://dx.doi.org/10.3390/diseases7020034DOI Listing

Growth Benefits of Own Mother's Milk in Preterm Infants Fed Daily Individualized Fortified Human Milk.

Nutrients 2019 Apr 3;11(4). Epub 2019 Apr 3.

Department of Neonatology, University of Liège, CHU and CHR Liège, 4000 Liège, Belgium.

The influence of types of human milk (HM)-raw own mother's milk (OMM), pasteurized OMM, and donor milk (DM)-was evaluated for growth in premature infants fed exclusively HM with controlled nutritional intakes using daily individualized HM fortification (IHMF). Growth and nutritional intakes were prospectively collected in preterm infants (<32 weeks) fed IHMF and compared in infants fed predominantly (≥75%) OMM and DM. The influence of HM types (raw OMM, pasteurized OMM, and DM) on growth were also evaluated in the whole population. Read More

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http://dx.doi.org/10.3390/nu11040772DOI Listing

Epidemiology of Meningitis in Canadian Neonatal Intensive Care Units.

Pediatr Infect Dis J 2019 May;38(5):476-480

Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital.

Background: Meningitis is a serious disease that occurs more commonly in the neonatal period than in any other age group. Recent data from large national cohorts are needed to determine if the epidemiology of neonatal meningitis (NM) has changed.

Aim: To assess the rates, causative organisms, risk factors, temporal trends and short-term outcomes of NM in Canadian Neonatal Intensive Care Units (NICUs). Read More

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http://Insights.ovid.com/crossref?an=00006454-201905000-0000
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http://dx.doi.org/10.1097/INF.0000000000002247DOI Listing
May 2019
1 Read

Commentary on 'Lower versus Higher Oxygen Concentrations Titrated to Target Oxygen Saturations during Resuscitation of Preterm Infants at Birth'.

Neonatology 2019 Apr 15;115(3):278-282. Epub 2019 Apr 15.

Division of Neonatal-Perinatal Medicine, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1159/000495315DOI Listing

Chest electrical impedance tomography measures in neonatology and paediatrics - a survey on clinical usefulness.

Physiol Meas 2019 Apr 15. Epub 2019 Apr 15.

Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, GERMANY.

Objective: Chest electrical impedance tomography (EIT) is currently applied in neonatal and paediatric patients mainly within clinical studies. The findings of these studies imply that lung monitoring using EIT provides valuable information on regional lung ventilation and aeration at the bedside that might improve the therapy and care of this fragile patient population. In view of this postulated future use of EIT in neonatology and paediatrics we have conducted an international survey to assess the perceived usefulness of several measures derived from EIT examinations. Read More

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http://dx.doi.org/10.1088/1361-6579/ab1946DOI Listing

Non-invasive estimation of brain-volume in infants.

Early Hum Dev 2019 Apr 12;132:52-57. Epub 2019 Apr 12.

Department for Neonatology and Pediatric Intensive Care Medicine, Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus Dresden, Technische Universität Dresden, Germany. Electronic address:

Background: Neurological development is determined by brain growth. Methods to measure total brain volume (TBV) in clinical settings are limited. MR-imaging represents the gold-standard. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03783782193002
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http://dx.doi.org/10.1016/j.earlhumdev.2019.03.020DOI Listing
April 2019
1 Read

Design of a Targeted Sequencing Assay to Detect Rare Mutations in Circulating Tumor DNA.

Genet Test Mol Biomarkers 2019 Apr;23(4):264-269

1 Clinical Laboratory, Longgang Central Hospital of Shenzhen, Shenzhen, China.

Background: Qualitative and quantitative detection of circulating tumor DNA (ctDNA) is a liquid biopsy technology used for early cancer diagnosis. However, the plasma ctDNA content is extremely low, so it is difficult to detect somatic mutations of tumors using conventional sequencing methods. Target region sequencing (TRS) technology, through enrichment of the target genomic region followed by next generation sequencing, overcomes this challenge and has been widely used in ctDNA sequencing. Read More

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https://www.liebertpub.com/doi/10.1089/gtmb.2018.0173
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http://dx.doi.org/10.1089/gtmb.2018.0173DOI Listing
April 2019
1 Read

Health-related quality of life during pregnancy: a repeated measures study of changes from the first trimester to birth.

Acta Obstet Gynecol Scand 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.

Introduction: The objective was to evaluate the quality of life of pregnant women with a full-term birth from the first trimester to the 9th month using the EQ5D-3L questionnaire, comparing physiological, simple pathological or complex pathological pregnancies.

Material And Methods: A prospective cohort of 500 pregnant women over the age of 18 was monitored between 2015 and 2017 at the Toulouse University Hospital (France). The data were collected monthly with an online report. Read More

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http://dx.doi.org/10.1111/aogs.13624DOI Listing

MYRF haploinsufficiency causes 46,XY and 46,XX disorders of sex development: bioinformatics consideration.

Hum Mol Genet 2019 Apr 1. Epub 2019 Apr 1.

Department of Human Genetics.

Disorders of sex development (DSDs) are defined as congenital conditions in which chromosomal, gonadal or anatomical sex is atypical. In many DSD cases, genetic causes remain to be elucidated. Here, we performed a case-control exome sequencing study comparing gene-based burdens of rare damaging variants between 26 DSD cases and 2625 controls. Read More

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http://dx.doi.org/10.1093/hmg/ddz066DOI Listing

Informed Consent for Bedside Procedures in Pediatric and Neonatal ICUs: A Nationwide Survey.

Pediatr Crit Care Med 2019 Apr 5. Epub 2019 Apr 5.

Division of Neonatology, Department of Pediatrics, Evanston Hospital, NorthShore University HealthSystem, Evanston, IL.

Objectives: Primary objectives were to discover current practices of informed consent for bedside procedures in the PICU and neonatal ICU and how trainees learn to obtain consent. We also attempted to gauge if program directors felt that one method of consent was subjectively superior to another in the way it fulfilled established ethical criteria for informed consent.

Design: An online anonymous survey. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001921DOI Listing

Bacterial Colonization of the Hospitalized Newborn: Competition Between Staphylococcus aureus and Staphylococcus epidermidis.

Pediatr Infect Dis J 2019 Apr 10. Epub 2019 Apr 10.

From the Division of neonatology, Department of Pediatrics, School of Medicine, University of California Davis, Sacramento, California.

Background: In adults, Staphylococcus epidermidis and Staphylococcus aureus compete for colonization of the nasal mucosa and S. epidermidis strains that produce the Esp serine protease eradicate S. aureus nasal colonization. Read More

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http://dx.doi.org/10.1097/INF.0000000000002285DOI Listing

A novel Ser40Trp variant in IFITM5 in a family with osteogenesis imperfecta and review of the literature.

Clin Dysmorphol 2019 Apr 10. Epub 2019 Apr 10.

Department of Paediatrics, KK Women's and Children's Hospital.

Osteogenesis imperfecta, is a genetically and clinically heterogeneous connective tissue disorder that disrupts bone architecture, making it fragile and more prone to fractures. While more than 85% of cases are due to variants in COL1A1 and COL1A2, variants in noncollagen genes have been identified in the remaining cases. The recurring heterozygous variant in IFITM5 (c. Read More

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http://dx.doi.org/10.1097/MCD.0000000000000279DOI Listing
April 2019
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Oral Sirolimus: An Option in the Management of Neonates with Life-Threatening Upper Airway Lymphatic Malformations.

Lymphat Res Biol 2019 Apr 13. Epub 2019 Apr 13.

2 Department of Pediatric Plastic Surgery, and La Paz Children's Hospital, Madrid, Spain.

Background: Mechanistic target of rapamycin (mTOR) inhibitors are being used off-label showing promising results in patients with vascular anomalies. Children with lymphatic malformations (LMs) involving the airway benefit from sirolimus therapy soon after birth, reducing the need of tracheostomy. Available information about efficacy and side effects in neonates remains poor. Read More

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http://dx.doi.org/10.1089/lrb.2018.0068DOI Listing

Breast Milk Lipidomics: Insights to Infant Health Requirements and Targeted Strategies for the Vulnerable.

Authors:
Camilia R Martin

Breastfeed Med 2019 Apr;14(S1):S13-S14

Department of Neonatology, Beth Israel Deaconess Medical Center, Harvard Medical School Boston, Boston, Massachusetts.

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http://dx.doi.org/10.1089/bfm.2019.0034DOI Listing

Mother's Own Milk: How Does It Differ from Donor Milk for the Baby.

Authors:
Josef Neu

Breastfeed Med 2019 Apr;14(S1):S3-S4

Division of Neonatology, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1089/bfm.2019.0036DOI Listing

Clinical Studies of Lactoferrin in Neonates and Infants: An Update.

Authors:
Paolo Manzoni

Breastfeed Med 2019 Apr;14(S1):S25-S27

Division of Pediatrics and Neonatology, Degli Infermi Hospital, Biella, Italy.

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http://dx.doi.org/10.1089/bfm.2019.0033DOI Listing

EEG Findings in Infants With Neonatal Abstinence Syndrome Presenting With Clinical Seizures.

Front Pediatr 2019 29;7:111. Epub 2019 Mar 29.

Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, KY, United States.

Neonatal abstinence syndrome (NAS) refers to a constellation of signs occurring in newborn infants who were exposed to opioids or opiates . These manifestations include poor feeding, gastrointestinal disorders, abnormal sleep patterns, and neurological signs such as jitteriness, tremors, and seizures (1, 2). Myoclonus, jitteriness, and tremors often may be interpreted as seizures and therefore treated as epileptic seizures. Read More

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http://dx.doi.org/10.3389/fped.2019.00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449643PMC

Risk Factors for Surgical Site Infection in Neonates: A Systematic Review of the Literature and Meta-Analysis.

Front Pediatr 2019 29;7:101. Epub 2019 Mar 29.

Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Surgical site infections (SSI) contribute to postoperative morbidity and mortality in children. Our aim was to evaluate the prevalence and identify risk factors for SSI in neonates. Using a defined strategy, three investigators searched articles on neonatal SSI published since 2000. Read More

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http://dx.doi.org/10.3389/fped.2019.00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449628PMC

Barber Say Syndrome (A New Case Report).

Indian Dermatol Online J 2019 Mar-Apr;10(2):158-161

Department of Family Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Barber Say syndrome (BSS) is a rare ectodermal dysplasia with neonatal onset characterized by congenital generalized hypertrichosis, atrophic skin, ectropion and macrostomia. A literature review showed less than 20 previously reported cases of Barber Say syndrome. This presentation reports a one day old female with syndrome face, low hairline, coarse face, macrostomia, thin upper lip, bilateral ectropion and hypertelorism, hypertrichosis, senile skin appearance, hypoplastic nipples and one area of mild skin atrophy. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_68_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434745PMC
April 2019
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Actual body weight-based vancomycin dosing in neonates.

J Chemother 2019 Apr 14:1-6. Epub 2019 Apr 14.

b Department of Pharmacology , General University Hospital, 1st Faculty of Medicine Charles University in Prague , Czech Republic , Prague , Czech Republic.

This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill neonates and to propose an easy applicable dosing nomogram for initial treatment. Individual vancomycin pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a one-compartmental model. A linear regression model was used for examination of covariates. Read More

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https://www.tandfonline.com/doi/full/10.1080/1120009X.2019.1
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http://dx.doi.org/10.1080/1120009X.2019.1599574DOI Listing
April 2019
1 Read