30,975 results match your criteria Neonatology Today[Journal]


Novel PHOX2B mutations in congenital central hypoventilation syndrome.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.

Background: Congenital central hypoventilation syndrome (CCHS) is caused by the mutation of PHOX2B. Approximately 90% of cases were found to carry polyalanine repeat expansion mutation (PARM), and the remaining 10% had non-PARM (NPARM). In PARMs, the length of the polyalanine expansion correlates with clinical disease severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.13812DOI Listing
February 2019

Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study.

PLoS One 2019 20;14(2):e0210999. Epub 2019 Feb 20.

Department of Pediatrics, Neonatology, Children´s Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an additive to increase the levels of macronutrients and micronutrients available to VLBW infants. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210999PLOS
February 2019

Green Breast Milk Following Ingestion of Blue-Green Algae: A Case Report.

Breastfeed Med 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Neonatology, The Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Breast milk is an excellent nutritional source for newborns, and a change in its color can be alarming to both mother and physician, and may prevent breastfeeding. Different colors of breast milk have been reported such as blood-stained, blue, and bluish-green. We present the first case of green breast milk caused by maternal ingestion of blue-green algae pills immediately before and after delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/bfm.2018.0184DOI Listing
February 2019

miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury.

Biomed Pharmacother 2019 Feb 19;112:108664. Epub 2019 Feb 19.

Neonatal Medical Center, Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. Electronic address:

Acute lung injury (ALI) is the leading cause of human death, and it is widely accepted that the runaway inflammation is an important risk for the development of ALI. In the present study, we aimed to investigate the effect of miR-16 on lipopolysaccharide-induced acute lung injury in mice, especially focusing on Toll-like receptor 4 (TLR4) and NF-kB signaling pathway as well as NOD-like receptor protein 3 (NLRP3) inflammasome activation. We established in vivo and in vitro model of ALI using LPS and demonstrated that miR-16 expression was down-regulated in lung tissue as well as A549 cells after 8 h of LPS treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.108664DOI Listing
February 2019

A focus on sexual and reproductive health is central to achieving RANZCOG's goal of excellence in women's health care.

Aust N Z J Obstet Gynaecol 2019 Feb;59(1):18-20

Department of Women's and Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajo.12949DOI Listing
February 2019

Analysis of detection results of thyroid function-related indexes in pregnant women and establishment of the reference interval.

Exp Ther Med 2019 Mar 27;17(3):1749-1755. Epub 2018 Dec 27.

Clinical Laboratory Department, Shandong Medical College, Linyi, Shandong 276000, P.R. China.

Detection results of free thyroxine (FT4), thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb) in pregnant women in Linyi region were investigated. A total of 22,235 healthy pregnant women admitted to Women and Children's Health Care Hospital of Linyi from October 2016 to October 2017 were selected and divided into the first-trimester, second-trimester and third-trimester pregnancy groups. Non-pregnant women in the same period were selected as the control group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2018.7135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364174PMC

Validation of the disposable T-piece resuscitator (Neo-Tee): a bench study.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 19. Epub 2019 Feb 19.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: The Neo-Tee Infant T-piece resuscitator is a disposable T-piece resuscitator. The aim of this bench study was to assess the accuracy of the Neo-Tee using a measurement set-up and settings mimicking clinical practice.

Study Design: Nine Neo-Tee devices were tested using a face mask interface and a manikin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2018-315298DOI Listing
February 2019

Implementation of an individual patient prospective database of hospital births in Sri Lanka and its use for improving quality of care.

BMJ Open 2019 Feb 19;9(2):e023706. Epub 2019 Feb 19.

WHO Collaborating Centre, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.

Objectives: This study was aimed at piloting a prospective individual patient database on hospital deliveries in Colombo, Sri Lanka, and at exploring its use for developing recommendations for improving quality of care (QoC).

Design: Observational study.

Setting: De Soysa Maternity Hospital, the largest referral hospital for maternity care in Sri Lanka. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023706DOI Listing
February 2019

Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis.

CMAJ Open 2019 Jan-Mar;7(1):E88-E93. Epub 2019 Feb 18.

Children's & Women's Health Centre of British Columbia (Claydon, Popescu, Christopherson, Human, Solimano, Lavoie); Divisions of Neonatology (Popescu, Shaiba, Solimano, Lavoie) and Cardiology (Human), Department of Pediatrics, University of British Columbia; British Columbia Children's Hospital Research Institute (Popescu, Human, Lavoie), Vancouver, BC; Victoria General Hospital (Taylor), Victoria, BC; University of Toronto (Shaiba), Toronto, Ont.

Background: It has been hypothesized that 4 doses of palivizumab, a neutralizing monoclonal antibody against respiratory syncytial virus (RSV), administered during a fixed-date RSV season may reduce hospital admissions comparably to the standard 5-dose schedule. We report outcomes in children with congenital heart disease approved to receive this 4-dose palivizumab schedule in British Columbia.

Methods: We performed a population-based descriptive cohort analysis of all 406 approved palivizumab courses over 4 seasons (2012/13 to 2015/16) in 325 children with hemodynamically significant congenital heart disease enrolled in the British Columbia RSV Immunoprophylaxis Program. Read More

View Article

Download full-text PDF

Source
http://cmajopen.ca/lookup/doi/10.9778/cmajo.20180167
Publisher Site
http://dx.doi.org/10.9778/cmajo.20180167DOI Listing
February 2019
1 Read

Hyperferritinaemia following intrauterine transfusions for Rh isoimmunisation.

BMJ Case Rep 2019 Feb 18;12(2). Epub 2019 Feb 18.

Neonatology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Intrauterine transfusion is one of the mainstays of treatment in isoimmunised pregnancies guided by the changes in middle cerebral artery Doppler of the fetus. The common postnatal complications associated with Rh isoimmunisation are high unconjugated bilirubin requiring blood exchange transfusions, cholestasis due to bile inspissation, thrombocytopenia and anaemia. Hyperferritinaemia is an uncommon adverse effect observed in Rh isoimmunised pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2018-227225DOI Listing
February 2019

[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):125-130

Department of Neonatology, Zhongshan Hospital Affiliated to Sun Yat-sen University, Zhongshan, Guangdong 528403, China.

Objective: To study the association between the expression of the MDR3 gene and the pathogenesis of parenteral nutrition-associated cholestasis (PNAC) in preterm infants.

Methods: Among the preterm infants who were admitted to the hospital from June 2011 to November 2017 and received parenteral nutrition for more than 14 days, 80 who did not develop PNAC were enrolled as non-PNAC group, and 76 who developed PNAC were enrolled as PNAC group. On days 1, 14, 30, 60 and 90 after birth, serum hepatobiliary biochemical parameters [alanine aminotransferase (ALT), total bilirubin (TBil), direct bilirubin (DBil), total bile acid (TBA) and gamma-glutamyl transpeptidase (γ-GT)], fibrosis indices [hyaluronic acid, laminin, procollagen III N-terminal peptide and type IV collagen] and clinical manifestations were observed. Read More

View Article

Download full-text PDF

Source
February 2019

[Coagulation function and hemorrhagic diseases in preterm infants with different gestational ages].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):120-124

Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361000, China.

Objective: To study the correlation between coagulation function and gestational age in preterm infants and the possible value of coagulation function measurement in predicting hemorrhagic diseases.

Methods: The clinical data of preterm infants who were hospitalized between September 2016 and August 2017 were collected. The coagulation indicators were measured within 2 hours after birth. Read More

View Article

Download full-text PDF

Source
February 2019

[A multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):114-119

Department of Neonatology, Anhui Provincial Children's Hospital, Hefei 230051, China.

Objective: To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China.

Methods: Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants. Read More

View Article

Download full-text PDF

Source
February 2019

The SURV1VE trial-sustained inflation and chest compression versus 3:1 chest compression-to-ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns: study protocol for a cluster randomized controlled trial.

Trials 2019 Feb 19;20(1):139. Epub 2019 Feb 19.

Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, 10240 Kingsway Avenue NW, Edmonton, AB, T5H 3V9, Canada.

Background: The need for cardiopulmonary resuscitation (CPR) is often unexpected, and the infrequent use of CPR in the delivery room (DR) limits the opportunity to perform rigorous clinical studies to determine the best method for delivering chest compression (CC) to newborn infants. The current neonatal resuscitation guidelines recommend using a coordinated 3:1 compression-to-ventilation (C:V) ratio (CC at a rate of 90/min and ventilations at a rate of 30/min). In comparison, providing CC during a sustained inflation (SI) (CC + SI) significantly improved hemodynamics, minute ventilation, and time to return of spontaneous circulation (ROSC) compared to 3:1 C:V ratio in asphyxiated piglets. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3240-8DOI Listing
February 2019

A multidisciplinary approach to understanding skeletal dysplasias.

Expert Rev Endocrinol Metab 2011 Sep;6(5):731-743

d Department of Child Health, University of Glasgow, Royal Hospital for Sick Children (Yorkhill), Dalnair Street, Glasgow, G3 8SJ, UK.

The skeletal dysplasias are a heterogeneous group of conditions of abnormal cartilage and bone development, resulting in a wide range of phenotypes of variable severity from perinatal lethality to mild short stature. Elucidation of the molecular mechanisms underlying these disorders is allowing us to understand more about the etiology of these conditions and classify them based upon the underlying gene defect. This article will discuss the development of bone and cartilage in relation to these conditions, present a clinical approach to their diagnosis and management, and consider new avenues of therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/eem.11.61DOI Listing
September 2011

Maternal and Congenital Toxoplasmosis: Diagnosis and Treatment Recommendations of a French Multidisciplinary Working Group.

Pathogens 2019 Feb 18;8(1). Epub 2019 Feb 18.

Assistance Publique-Hôpitaux de Marseille, Department of Neonatal Medicine; Hospital of the Conception, 13005 Marseille, France.

Women infected with toxoplasmosis during pregnancy do not present symptoms in most cases, but the consequences of the congenital infection may be severe for the unborn child. Fetal damage can range from asymptomatic to severe neurological alterations to retinal lesions prone to potential flare up and relapses lifelong. Despite the possible severity of outcome, congenital toxoplasmosis (CT) is a neglected disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pathogens8010024DOI Listing
February 2019

Rational Use of Antibiotics in Neonates: Still in Search of Tailored Tools.

Healthcare (Basel) 2019 Feb 16;7(1). Epub 2019 Feb 16.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Rational medicine use in neonates implies the prescription and administration of age-appropriate drug formulations, selecting the most efficacious and safe dose, all based on accurate information on the drug and its indications in neonates. This review illustrates that important uncertainties still exist concerning the different aspects () of rational antibiotic use in neonates. Decisions to prescribe antibiotics are still not based on robust decision tools. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/healthcare7010028DOI Listing
February 2019

Comparison of Endotracheal Reintubation between Nasal High-Frequency Oscillation and Continuous Positive Airway Pressure in Neonates.

Am J Perinatol 2019 Feb 19. Epub 2019 Feb 19.

Division of Neonatology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Objective:  To compare the endotracheal reintubation between nasal high-frequency oscillation (nHFO) and nasal continuous positive airway pressure (nCPAP) with face mask groups who were followed up for up to 7 days.

Study Design:  We performed a retrospective cohort study of extubated neonates admitted between 2013 and 2017. We used a Cox's proportional hazards model to adjust for significant between-group differences in baseline characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1679932DOI Listing
February 2019

Use of Point-of-Care Gastric pH Testing to Assess the Efficacy of Acid Suppression Therapy in the Neonatal Intensive Care Unit.

Am J Perinatol 2019 Feb 19. Epub 2019 Feb 19.

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.

Objective:  The use of acid suppression therapies in newborns lacks efficacy and is associated with adverse effects. Point-of-care (POC) assessment of gastric aspirate pH may provide an objective, noninvasive measure of gastric acidity in tube fed infants. We conducted the present study to characterize the POC gastric pH levels in gastric tube fed infants before and after initiation of enteral omeprazole or ranitidine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1679917DOI Listing
February 2019

Cardiac left heart morphology and function in newborns with intrauterine growth restriction: relevance for long-term assessment.

Med Ultrason 2019 Feb;21(1):62-68

Medical Informatics and Biostatistics, department, Cluj Napoca, Romania Iuliu Hatieganu University of Medicine and Pharmacy.

Aim: To asses the cardiac morphology and functional changes specific for newborns from intrauterine growth restriction (IUGR) pregnancies.

Material And Method: A cohort of IUGR infants were evaluated by serial echocardiographies at delivery and at the first and six months follow-ups. IUGR newborn delivery status was compared to that of newborns in the control group according to gestational age (AGA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11152/mu-1667DOI Listing
February 2019

Simulation of a Spontaneous Vaginal Delivery and Neonatal Resuscitation in a Biocontainment Unit.

Health Secur 2019 Jan/Feb;17(1):18-26

Brian T. Garibaldi, MD, is Director, Johns Hopkins Biocontainment Unit, Department of Medicine, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD.

This article describes a large-scale scenario designed to test the capabilities of a US biocontainment unit to manage a pregnant woman infected with a high-consequence pathogen, and to care for a newborn following labor and spontaneous vaginal delivery. We created and executed a multidisciplinary functional exercise with simulation to test the ability of the Johns Hopkins Hospital biocontainment unit (BCU) to manage a pregnant patient in labor with an unknown respiratory illness and to deliver and stabilize her neonate. The BCU Exercise and Drill Committee established drill objectives and executed the exercise in partnership with the Johns Hopkins Simulation Center in accordance with Homeland Security and Exercise Program guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hs.2018.0090DOI Listing
February 2019

Sonographic lower uterine segment thickness after prior cesarean section to predict uterine rupture: a systematic review and meta-analysis.

Acta Obstet Gynecol Scand 2019 Feb 19. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, ON, Canada.

Introduction: Cesarean section rates are increasing with a decrease in the rate of trial of labor after cesarean section. The objective of this study was to systematically review predictive characteristics of sonographic measurement of lower uterine segment thickness for uterine rupture during labor.

Materials And Methods: The review was carried out in agreement with PRISMA and SEDATE guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13585DOI Listing
February 2019

STRIDER NZAus: A multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction.

BJOG 2019 Feb 19. Epub 2019 Feb 19.

College of Life Sciences, University of Leicester, Leicester, United Kingdom.

Objective: To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early-onset fetal growth restriction.

Design: A randomised placebo-controlled trial.

Setting: Thirteen maternal-fetal medicine units across New Zealand and Australia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15658DOI Listing
February 2019

Amplitude-integrated electroencephalography shows alterations in children born preterm displaying poor literacy precursor skills.

Acta Paediatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatrics II (Neonatology), Medical University of Innsbruck, Innsbruck, Austria.

Aim: To assess whether amplitude-integrated electroencephalography (aEEG) alterations in the newborn period are associated with poor precursor skills of literacy at five years of age in children born preterm.

Methods: Between October 2007 and September 2011 248 preterm infants were eligible for the study at Innsbruck Medical University Hospital. aEEG was analysed for dominating background activity, calculation of the percentage of continuous activity, the Burdjalov scoring system, the minimum, mean and maximum amplitude. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.14755DOI Listing
February 2019

Neurodevelopmental outcome at 2 years of age in preterm infants with late-onset sepsis.

Eur J Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Late-onset sepsis is associated with impaired neurodevelopmental outcome in preterm infants. This prospective cohort study aims to establish the effect of sepsis after 72 h of life on cognitive, psychomotor, and language development of preterm infants (below 32 weeks gestational age and/or below 1500 g). At 2 years corrected age, neurodevelopmental outcome was tested using Bayley's Scales of Infant Development-II, Lexilijst (lexical development questionnaire), and behavior checklists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-019-03339-2DOI Listing
February 2019

Maternal hypothyroidism and future pediatric neurological morbidity of the offspring.

Arch Gynecol Obstet 2019 Feb 18. Epub 2019 Feb 18.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, 151 Izak Rager Ave., 84101, Beer-Sheva, Israel.

Background: Maternal hypothyroidism in pregnancy has been associated with neurocognitive impairment in exposed children, ranging from psychomotor-developmental delay to lower IQ scores.

Objective: To investigate the long-term neurological morbidity of children to hypothyroid mothers during pregnancy.

Study Design: A population-based cohort study was performed including all deliveries occurring in a period of 20 years at a tertiary medical center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00404-019-05092-1DOI Listing
February 2019

Polypeptide Nanogels With Different Functional Cores Promote Chemotherapy of Lung Carcinoma.

Front Pharmacol 2019 4;10:37. Epub 2019 Feb 4.

Department of Geriatrics, The First Hospital of Jilin University, Changchun, China.

Two kinds of tumor microenvironment-responsive polypeptide nanogels were developed for intracellular delivery of cytotoxics to enhance the antitumor efficacies and reduce the side effects in the chemotherapy of lung carcinoma. The sizes of both doxorubicin (DOX)-loaded nanogels methoxy poly(ethylene glycol)-poly(L-phenylalanine--L-cystine) [mPEG-P(LP--LC)] and methoxy poly(ethylene glycol)-poly(L-glutamic acid--L-cystine) [mPEG-P(LG--LC)] (NGP/DOX and NGG/DOX) were less than 100 nm, which was appropriate for the enhanced permeability and retention (EPR) effect. The bigger and smaller scale of nanoparticle could induce the elimination of reticuloendothelial system (RES) and decrease the circulating half-life, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369202PMC
February 2019

How to use abdominal X-rays in preterm infants suspected of developing necrotising enterocolitis.

Arch Dis Child Educ Pract Ed 2019 Feb 18. Epub 2019 Feb 18.

Department of Neonatology, University College London Hospital, London, UK.

Necrotising enterocolitis (NEC) in preterm babies is a serious gastrointestinal emergency with potentially devastating consequences. Prompt and accurate diagnosis continues to be a challenge for health professionals. Early identification of clinical warning signs is extremely important, but the diagnosis relies heavily on the interpretation of abdominal radiographs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/archdischild-2018-315252DOI Listing
February 2019

Ferritin in serum and urine: A pilot study.

Blood Cells Mol Dis 2019 Feb 8. Epub 2019 Feb 8.

Division of Hematology/Oncology, University of Utah, Salt Lake City, UT, USA.

Serum ferritin reflects total body iron stores, thus a low serum ferritin is used as a parameter of iron deficiency. In healthy adults in Japan, urine ferritin levels were about 5% of serum ferritin levels, with a correlation coefficient of 0.79. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcmd.2019.02.001DOI Listing
February 2019

[Follow-up recommendations for the late preterm infant].

An Pediatr (Barc) 2019 Feb 15. Epub 2019 Feb 15.

Grupo SEN34-36/ACUNA, Sociedad Española de Neonatología, España; Servicio de Pediatría-Neonatología, SCIAS, Hospital Barcelona, Barcelona, España.

The population of late preterm infants (PT), those born between 34+0 and 36+6 weeks of gestation, accounts for 70-74% of all premature infants, and is not specifically included in most of the follow-up protocols for preterm infants. For many years, PTs have been handled as if they were term newborns, which has led to a limited knowledge of their outcome in the medium and long term. Their neonatal morbidity is associated with a higher incidence of postnatal complications, with an increased rate of hospital re-admissions due to malnutrition, hyperbilirubinaemia, and respiratory problems, when compared to term infants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anpedi.2019.01.008DOI Listing
February 2019

Immigrant Children With Special Health Care Needs: A Review.

Authors:
Sandra McKay

Curr Probl Pediatr Adolesc Health Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Division of Neonatology, University of Texas Health Science Center at Houston, TX. Electronic address:

This review was conducted to evaluate the current literature surrounding immigrant children with special health care needs. The focus of the review was to determine what evaluations have been done to educate primary care providers on general characteristics of this high-risk population and barriers that may impact care of the child. A review of the literature was conducted looking at PUBMED/MEDLINE and Cochrane databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cppeds.2019.01.004DOI Listing
February 2019

A novel in vitro model of primary human pediatric lung epithelial cells.

Pediatr Res 2019 Feb 18. Epub 2019 Feb 18.

Division of Neonatology, University of Rochester Medical Center, Rochester, NY, USA.

Background: Current in vitro human lung epithelial cell models derived from adult tissues may not accurately represent all attributes that define homeostatic and disease mechanisms relevant to the pediatric lung.

Methods: We report methods for growing and differentiating primary Pediatric Human Lung Epithelial (PHLE) cells from organ donor infant lung tissues. We use immunohistochemistry, flow cytometry, quantitative RT-PCR, and single cell RNA sequencing (scRNAseq) analysis to characterize the cellular and transcriptional heterogeneity of PHLE cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41390-019-0340-9DOI Listing
February 2019

2018 Update on Pediatric Medical Overuse: A Review.

JAMA Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Importance: Efforts to combat medical overuse have gained traction in recent years, but success has been intermittent and shortcomings have been recognized. A commitment to a strong evidence base is needed to more broadly engage clinicians and reduce overuse.

Observations: A structured MEDLINE search and a manual review of tables of contents from selected high-impact journals was performed to identify original research published in 2017 relevant to pediatric overuse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapediatrics.2018.5550DOI Listing
February 2019

Late stillbirth due to listeriosis.

Autops Case Rep 2018 Oct-Dec;8(4):e2018051. Epub 2018 Oct 22.

Hospital Universitário Puerta del Mar, Department of Pediatrics, Division of Neonatology. Cádiz, Spain.

Listeriosis is a sporadic infectious disease, which affects high-risk populations, such as the elderly, pregnant women, newborns, and immunocompromised patients. During pregnancy, listeriosis usually presents like a mild non-specific infection, but it may be responsible for fetal loss, preterm labor, early onset neonatal sepsis, and neonatal death. We report the case of a late stillbirth secondary to maternal chorioamnionitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4322/acr.2018.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360831PMC
October 2018
1 Read

Case Report on a Rare Disease in Lithuania: Congenital Chloride Diarrhea.

J Pediatr Genet 2019 Mar 25;8(1):24-26. Epub 2018 Aug 25.

Department of Genetics and Molecular Medicine, Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania.

Congenital chloride diarrhea (CCD) is a rare disease, manifesting with secretory diarrhea and life-threatening electrolyte imbalance during infancy. The early diagnosis of CCD is therefore necessary for the adequate treatment. The long-term prognosis of properly managed CCD is favorable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1669437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375714PMC

Clinical and molecular findings in nine new cases of tetrasomy 18p syndrome: FISH and array CGH characterization.

Mol Cytogenet 2019 8;12. Epub 2019 Feb 8.

1Laboratory of Human cytogenetics, Molecular Genetics and Biology of Reproduction, Farhat Hached University Hospital, Sousse, Tunisia.

Background: Small Supernumerary Marker Chromosomes (sSMC) are rare chromosomal abnormalities, which have abnormal banding arrangement and take many shapes. Several disorders have been correlated with sSMC presence. The aim of this study is to characterize the sSMC derived from chromosome 18 by Fluorescence in situ hybridization (FISH) and Array Comparative Genomic Hybridization (aCGH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13039-019-0414-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368812PMC
February 2019

The hepatic innate immune response is lobe-specific in a murine model endotoxemia.

Innate Immun 2019 Feb;25(2):144-154

Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, USA.

The liver plays a central role in the innate immune response to endotoxemia. While previous studies have demonstrated lobe-specific transcriptional responses to various insults, whether this is true in response to endotoxemia is unknown. We sought to assess whether there were significant intra- and inter-lobe differences in the murine hepatic innate immune transcriptional response to endotoxemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753425918823900DOI Listing
February 2019

Phenotype, treatment practice and outcome in the cobalamin-dependent remethylation disorders and MTHFR deficiency: Data from the E-HOD registry.

J Inherit Metab Dis 2019 Feb 17. Epub 2019 Feb 17.

Inherited Metabolic Diseases Clinic, Section of Clinical Genetics and Metabolism, University of Colorado Denver, Aurora, Colorado.

Aim: To explore the clinical presentation, course, treatment and impact of early treatment in patients with remethylation disorders from the European Network and Registry for Homocystinurias and Methylation Defects (E-HOD) international web-based registry.

Results: This review comprises 238 patients (cobalamin C defect n = 161; methylenetetrahydrofolate reductase deficiency n = 50; cobalamin G defect n = 11; cobalamin E defect n = 10; cobalamin D defect n = 5; and cobalamin J defect n = 1) from 47 centres for whom the E-HOD registry includes, as a minimum, data on medical history and enrolment visit. The duration of observation was 127 patient years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jimd.12041DOI Listing
February 2019

Understanding and provision of preconception care by general practitioners.

Aust N Z J Obstet Gynaecol 2019 Feb 17. Epub 2019 Feb 17.

Charles Perkins Centre, The University of Sydney, Sydney, Australia.

Background: Preconception care (PCC) defines health interventions prior to conception aimed at improving pregnancy and infant outcomes.

Aim: To explore the understanding and provision of PCC by general practitioners (GPs) within the Sydney Local Health District.

Materials And Methods: A questionnaire developed with GPs assessed structure and content of PCC provided, attitudes toward PCC and perceived barriers and facilitators. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajo.12962DOI Listing
February 2019

Atypical Segmental Spinal Dysgenesis: Prenatal Diagnosis With Postpartum Short-Term Follow-Up.

J Obstet Gynaecol Can 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogc.2018.07.012DOI Listing
February 2019

Use of a maternal newborn audit and feedback system in Ontario: a collective case study.

BMJ Qual Saf 2019 Feb 16. Epub 2019 Feb 16.

Better Outcomes Registry & Network (BORN), Children's Hospital of Eastern Ontario - Ottawa Children's Treatment Centre (CHEO-OCTC), Ottawa, Ontario, Canada.

Background: As part of a larger study examining the effectiveness of the Maternal Newborn Dashboard, an electronic audit and feedback system to improve maternal-newborn care practices and outcomes, the purpose of this study was to increase our understanding of factors explaining variability in performance after implementation of the Dashboard in Ontario, Canada.

Methods: A collective case study. A maximum variation sampling approach was used to invite hospitals reflecting different criteria to participate in a 1-day to 2-day site visit by the research team. Read More

View Article

Download full-text PDF

Source
http://qualitysafety.bmj.com/lookup/doi/10.1136/bmjqs-2018-0
Publisher Site
http://dx.doi.org/10.1136/bmjqs-2018-008354DOI Listing
February 2019
2 Reads

Dysgénésie spinale segmentaire atypique : diagnostic prénatal et suivi postpartum à court terme.

J Obstet Gynaecol Can 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jogc.2018.10.029DOI Listing
February 2019

[Use of off-label drugs in neonatal intensive care].

An Pediatr (Barc) 2019 Feb 13. Epub 2019 Feb 13.

Unidad de Epidemiología Clínica y Bioestadística, Complexo Hospitalario Universitario A Coruña (CHUAC)-Instituto de Investigación Biomédica A Coruña (INIBIC) Sergas, A Coruña, España.

Objective: To evaluate the prevalence of non-approved prescriptions (off-label and unlicensed) in a Neonatal Intensive Care Unit (NICU), and to describe factors of the neonate associated with its use.

Materials And Methods: Observational prospective study in a level III NICU during a 6-month period. Every prescription was analysed using the summary of product characteristics as a reference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anpedi.2018.12.015DOI Listing
February 2019
1 Read

End-of-Life Decisions 20 Years after EURONIC: Neonatologists' Self-Reported Practices, Attitudes, and Treatment Choices in Germany, Switzerland, and Austria.

J Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Objective: To assess changes in attitudes of neonatologists regarding the care of extremely preterm infants and parental involvement over the last 20 years.

Study Design: Internet-based survey (2016) involving 170 tertiary neonatal intensive care units in Austria, Switzerland, and Germany using the European Project on Parents' Information and Ethical Decision Making in Neonatal Intensive Care Units questionnaire (German edition) with minor modifications to the original survey from 1996 to 1997.

Results: The 2016 survey included 104 respondents (52. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2018.12.064DOI Listing
February 2019
1 Read

Necrotizing Enterocolitis Pathophysiology: How Microbiome Data Alter Our Understanding.

Clin Perinatol 2019 Mar 12;46(1):29-38. Epub 2018 Dec 12.

Neonatology, Department of Pediatrics, University of Chicago, 5841 South Maryland Avenue, MC 6060, Chicago, IL 60637, USA.

Necrotizing enterocolitis is a major cause of mortality and morbidity in the preterm infant population. The gut microbiome is of particular interest in research surrounding necrotizing enterocolitis, because variations in the intestinal microbiota seem to correlate with the risk of inflammation and disease. Recent advances in non-culture-based genomic sequencing have also allowed for more intricate analyses of the intestinal microbiome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clp.2018.10.003DOI Listing
March 2019
1 Read

Role of Abdominal US in Diagnosis of NEC.

Authors:
Jae H Kim

Clin Perinatol 2019 Mar 20;46(1):119-127. Epub 2018 Dec 20.

SPIN Program, San Diego Mothers' Milk Bank, Division of Neonatology, UC San Diego, 9300 Campus Point Drive MC7774, La Jolla, CA 92037, USA; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children's Hospital-San Diego, 3020 Children's Way, San Diego, CA 92123. Electronic address:

Current assessment for and diagnosis of necrotizing enterocolitis (NEC) remain inadequate. The introduction of interrogating bowel with ultrasound when NEC is suspected or when NEC has occurred presents greater opportunity to characterize the physical changes that have occurred in the bowel wall structures. The evaluation of bowel by ultrasound has been shown to have high specificity for bowel necrosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00955108183143
Publisher Site
http://dx.doi.org/10.1016/j.clp.2018.10.006DOI Listing
March 2019
2 Reads

The value of delta neutrophil index in neonatal sepsis diagnosis, follow-up and mortality prediction.

Early Hum Dev 2019 Feb 13;131:6-9. Epub 2019 Feb 13.

Division of Neonatology, Department of Pediatrics, University of Health Sciences, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital, 06010, Ankara, Turkey; Division of Neonatology, Department of Pediatrics, Yildirim Beyazit University, 06800, Ankara, Turkey.

Background: The complete blood cell count (CBC) and peripheral blood smear were the most commonly ordered tests for the diagnosis of neonatal sepsis. Delta neutrophil index (DNI) shows leucocyte differentiation and calculated while CBC is performed.

Aims: We aimed to evaluate the value of DNI in neonatal sepsis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.earlhumdev.2019.02.003DOI Listing
February 2019
1 Read

Habituation and Novelty Detection fNIRS brain responses in 5 and 8 month old infants: The Gambia and UK.

Dev Sci 2019 Feb 16:e12817. Epub 2019 Feb 16.

Department of Medical Physics and Biomedical Engineering, University College London, UK.

The first 1000 days of life are a critical window of vulnerability to exposure to socio-economic and health challenges (i.e. poverty/undernutrition). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/desc.12817DOI Listing
February 2019
1 Read

Who's counting? Assessing the effects of a simulation-based training intervention on the accuracy of neonatal heart rate auscultation.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatrics, Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.

Objective: To determine if simulation-based medical education could improve pediatric residents' ability to accurately assess neonatal heart rate via auscultation.

Study Design: Primary outcomes included heart rate accuracy and Neonatal Resuscitation Program (NRP) group accuracy, defined as whether a heart rate estimation fell in the appropriate NRP algorithm group. Pediatric residents completed a pre-assessment and then participated in a simulation training intervention on high-fidelity manikins. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41372-019-0339-4DOI Listing
February 2019
1 Read

Use of very low tidal volumes during high-frequency ventilation reduces ventilator lung injury.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Medical and Surgical Research Unit, Instituto de Investigación Sanitaria Puerta de Hierro, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

The use of volume guarantee (VG) on high-frequency oscillatory ventilation (HFOV) allows to use fixed very low high-frequency tidal volume (VThf), maintaining adequate CO removal while potentially reducing the risk of ventilator-induced lung injury.

Objective: To demonstrate that the use of very low VThf can be protective compared with standard VThf on HFOV combined with VG in a neonatal animal model.

Study Design: Experimental study in 2-day-old piglets with induced respiratory distress syndrome ventilated with two different HFOV strategies combined with VG (10 Hz with high VThf versus 20 Hz with very low VThf at similar PaCO). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41372-019-0338-5DOI Listing
February 2019