700,136 results match your criteria Neonatal Paediatric and Child Health Nursing [Journal]


Effectiveness of Insulin Analogs Compared with Human Insulins in Pregnant Women with Diabetes Mellitus: Systematic Review and Meta-analysis.

Rev Bras Ginecol Obstet 2019 Feb 20;41(2):104-115. Epub 2019 Feb 20.

Universidade Federal de Alagoas, Maceió, AL, Brazil.

Diabetes during pregnancy has been linked to unfavorable maternal-fetal outcomes. Human insulins are the first drug of choice because of the proven safety in their use. However, there are still questions about the use of insulin analogs during pregnancy. Read More

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http://dx.doi.org/10.1055/s-0038-1676510DOI Listing
February 2019

["Crystal" and Pregnancy - The Preliminary Results of a Retrospective Study on the Course of Pregnancy and Delivery of Women Consuming Methamphetamine].

Z Geburtshilfe Neonatol 2019 Feb 20. Epub 2019 Feb 20.

Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Carl Gustav Carus Dresden, Dresden.

Introduction: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery.

Methods: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. Read More

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http://dx.doi.org/10.1055/a-0831-3642DOI Listing
February 2019

Unexpected term NICU admissions: a marker of obstetrical care quality?

Am J Obstet Gynecol 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA; Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Harvard University, Boston, MA.

Background: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices.

Objective: To examine the relative effects of patient characteristics and intrapartum events on unexpected NICU admissions, and to quantify the between-hospital variation in NICU admission rates among this group of neonates. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.001DOI Listing
February 2019

Delayed Clamping Versus Milking of Umbilical Cord in Preterm Infants: A Randomized Controlled Trial.

Am J Obstet Gynecol 2019 Feb 5. Epub 2019 Feb 5.

Department of Obstetrics and Gynecology, TriHealth, Cincinnati, OH.

Background: It has been established that delayed umbilical cord clamping in preterm infants results in improvement in neonatal anemia, need for transfusion, incidence of necrotizing enterocolitis, and intraventricular hemorrhage by increasing neonatal circulating blood volume. However, the effects of umbilical cord milking as an alternative to delayed clamping in preterm infants are unclear.

Objective: The primary objective of this study was to compare the effect of delayed clamping versus milking of the umbilical cord on the initial hematocrit concentration in preterm births (23-34 weeks). Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.234DOI Listing
February 2019

Kratom exposures reported to United States poison control centers: 2011-2017.

Clin Toxicol (Phila) 2019 Feb 20:1-8. Epub 2019 Feb 20.

a Center for Injury Research and Policy , The Research Institute at Nationwide Children's Hospital , Columbus , OH , USA.

Context: Kratom, or Mitragyna speciosa, is a plant indigenous to Southeast Asia that has gained national attention in the United States for its increased use in the self-management of opioid withdrawal and pain, as well as for concerns about its safety.

Methods: This study analyzes exposures to kratom reported to poison control centers (PCCs) in the United States during 2011-2017 from the National Poison Data System (NPDS).

Discussion: From 2011 through 2017, 1807 kratom exposures were reported to United States PCCs. Read More

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http://dx.doi.org/10.1080/15563650.2019.1569236DOI Listing
February 2019

Neonatal Organ Donation. Reply.

N Engl J Med 2019 Feb;380(8):798

Women and Infants Hospital of Rhode Island, Providence, RI.

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http://dx.doi.org/10.1056/NEJMc1900119DOI Listing
February 2019

Neonatal Organ Donation.

N Engl J Med 2019 02;380(8):797-798

New England Donor Services, Waltham, MA.

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http://dx.doi.org/10.1056/NEJMc1900119DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Novel PHOX2B mutations in congenital central hypoventilation syndrome.

Pediatr Int 2019 Feb 20. Epub 2019 Feb 20.

Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.

Background: Congenital central hypoventilation syndrome (CCHS) is caused by the mutation of PHOX2B. Approximately 90% of cases were found to carry polyalanine repeat expansion mutation (PARM), and the remaining 10% had non-PARM (NPARM). In PARMs, the length of the polyalanine expansion correlates with clinical disease severity. Read More

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http://dx.doi.org/10.1111/ped.13812DOI Listing
February 2019

The forgotten mothers of extremely preterm babies: a qualitative study.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

University of Hertfordshire.

Aims: To explore the experiences of mothers of extremely premature babies during their Neonatal Intensive Care Unit stay and transition home.

Background: Mothers of extremely preterm infants (28-weeks-or-less gestation) experience a continuum of regular and repeated stressful and traumatic events; during the perinatal period, while the Neonatal Intensive Care Unit, and during transition home.

Method: An interpretive description method guided this study. Read More

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http://dx.doi.org/10.1111/jocn.14820DOI Listing
February 2019

Adrenal steroids in female hypothyroid neonates: Unraveling an association between thyroid hormones & adrenal remodeling.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology, Metabolism and Diabetes, 1st Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Context: The adrenal gland undergoes significant remodeling during the neonatal period, an essential developmental process that still remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (TH), no human studies have been published. The effect of both hypo- and hyper-thyroidism has only been evaluated in adults, focusing on the mature adrenal. Read More

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http://dx.doi.org/10.1210/jc.2018-02013DOI Listing
February 2019

Green Breast Milk Following Ingestion of Blue-Green Algae: A Case Report.

Breastfeed Med 2019 Feb 20. Epub 2019 Feb 20.

1 Department of Neonatology, The Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Breast milk is an excellent nutritional source for newborns, and a change in its color can be alarming to both mother and physician, and may prevent breastfeeding. Different colors of breast milk have been reported such as blood-stained, blue, and bluish-green. We present the first case of green breast milk caused by maternal ingestion of blue-green algae pills immediately before and after delivery. Read More

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http://dx.doi.org/10.1089/bfm.2018.0184DOI Listing
February 2019

Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning.

Clin Physiol Funct Imaging 2019 Feb 20. Epub 2019 Feb 20.

Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Clinical Physiology, Lund, Sweden.

Limited visualisation of the fetal heart and vessels by fetal ultrasound due to suboptimal fetal position, patient habitus and skeletal calcification may lead to missed diagnosis, overdiagnosis and parental uncertainty. Counseling and delivery planning may in those cases also be tentative. The recent fetal cardiac magnetic resonance (CMR) reconstruction method utilising tiny golden angle iGRASP (iterative Golden-angle RAdial Sparse Parallel MRI) allows for cine imaging of the fetal heart for use in clinical practice. Read More

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http://dx.doi.org/10.1111/cpf.12566DOI Listing
February 2019

Sensitivity analyses for average treatment effects when outcome is censored by death in instrumental variable models.

Stat Med 2019 Feb 20. Epub 2019 Feb 20.

Department of Statistics, Wharton School, University of Pennsylvania, Philadelphia, Pennsylvania.

Two problems that arise in making causal inferences for nonmortality outcomes such as bronchopulmonary dysplasia (BPD) are unmeasured confounding and censoring by death, ie, the outcome is observed only when subjects survive. In randomized experiments with noncompliance and no censoring by death, instrumental variable (IV) methods can be used to control for the unmeasured confounding. But, when there is censoring by death, the average causal treatment effect cannot be identified under usual assumptions but can be studied for a specific subpopulation by using sensitivity analysis with additional assumptions. Read More

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http://dx.doi.org/10.1002/sim.8117DOI Listing
February 2019

Iatrogenic diaphragmatic hernia in an infant following cardiac surgery: the culprit in a case of unresolved respiratory distress: Case report and review of the literature.

Cardiol Young 2019 Feb;29(2):238-240

2Department of Pediatric Cardiology,Johns Hopkins All Children's Hospital,St Petersburg,FL,USA.

Acquired diaphragmatic hernia is a rare complication of pediatric intervention or surgery. In this study, we report an infant with iatrogenic diaphragmatic hernia following neonatal complex congenital cardiac surgery, and then we review the associated literature. Read More

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http://dx.doi.org/10.1017/S1047951118001968DOI Listing
February 2019

Endotoxin-induced cerebral pathophysiology: differences between fetus and newborn.

Physiol Rep 2019 Feb;7(4):e13973

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.

As the comparative pathophysiology of perinatal infection in the fetus and newborn is uncertain, this study contrasted the cerebral effects of endotoxemia in conscious fetal sheep and newborn lambs. Responses to intravenous bacterial endotoxin (lipopolysaccharide, LPS) or normal saline were studied on three consecutive days in fetal sheep (LPS 1 μg/kg, n = 5; normal saline n = 5) and newborn lambs (LPS 2 μg/kg, n = 10; normal saline n = 5). Cerebro-vascular function was assessed by monitoring cerebral blood flow (CBF) and cerebral vascular resistance (CVR) over 12 h each day, and inflammatory responses were assessed by plasma TNF alpha (TNF-α), nitrate and nitrite concentrations. Read More

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http://dx.doi.org/10.14814/phy2.13973DOI Listing
February 2019

Neonatal pertussis diagnosis: low procalcitonin level and high lymphocyte count are able to discriminate pertussis from bacterial and viral infections.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Dipartimento di Pediatria Sistematica, Pediatria 1, AORN "Santobono-Pausilipon", Napoli, Italy.

Pertussis is quite frequent and severe among infants; therefore, rapid diagnosis and timely targeted therapy are essential. Although a molecular test for etiological diagnosis is now available, it may not be available everywhere, and therefore adjunctive diagnostic tests are still useful for presumptive diagnosis. We describe the use of procalcitonin (PCT) and lymphocyte count to discriminate among pertussis, bacterial and viral infections. Read More

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February 2019

Zika Virus Infects Newborn Monocytes Without Triggering a Substantial Cytokine Response.

J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Laboratório de Investigação em Dermatologia e Imunodeficiências LIM56, Instituto de Medicina Tropical, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, SP, BR.

Zika virus (ZIKV) is a clinically important flavivirus that can cause neurological disturbances in newborns. Here, we investigated comparatively the outcome of in vitro infection of newborn monocytes by ZIKV. We observed that neonatal cells show defective production of IL-1β, IL-10 and MCP-1 in response to ZIKV, albeit they are as efficient as adult cells in supporting viral infection. Read More

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http://dx.doi.org/10.1093/infdis/jiz075DOI Listing
February 2019

Generation of a human Charcot-Marie-Tooth disease type 1B (CMT1B) iPSC line, ZJUCHi001-A, with a mutation of c.292C>T in MPZ.

Stem Cell Res 2019 Feb 14;35:101407. Epub 2019 Feb 14.

The Children's Hospital Affiliated, Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou 310052, China; Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310020, China; Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou 310058, China. Electronic address:

The human iPSC cell line ZJUCHi001-A was established from renal epithelial cells present in urine (urinary cells) harvested from a 2-year-old Charcot-Marie-Tooth disease type 1B (CMT1B) patient carrying point mutation in MPZ (c.292C>T). Urinary cells were reprogrammed by retrovirus vectors containing reprogramming factors: OCT4, SOX2, KLF4 and c-MYC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18735061193003
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http://dx.doi.org/10.1016/j.scr.2019.101407DOI Listing
February 2019
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miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury.

Biomed Pharmacother 2019 Feb 19;112:108664. Epub 2019 Feb 19.

Neonatal Medical Center, Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. Electronic address:

Acute lung injury (ALI) is the leading cause of human death, and it is widely accepted that the runaway inflammation is an important risk for the development of ALI. In the present study, we aimed to investigate the effect of miR-16 on lipopolysaccharide-induced acute lung injury in mice, especially focusing on Toll-like receptor 4 (TLR4) and NF-kB signaling pathway as well as NOD-like receptor protein 3 (NLRP3) inflammasome activation. We established in vivo and in vitro model of ALI using LPS and demonstrated that miR-16 expression was down-regulated in lung tissue as well as A549 cells after 8 h of LPS treatment. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108664DOI Listing
February 2019

Severe congenital nephrogenic diabetes insipidus in a compound heterozygote with a new large deletion of the AQP2 gene. A case report.

Mol Genet Genomic Med 2019 Feb 19:e568. Epub 2019 Feb 19.

La Paz University Hospital, Medical and Molecular Genetics Institute (INGEMM), IdiPAZ, Madrid, Spain.

Background: Congenital nephrogenic diabetes insipidus (NDI) is a rare condition characterized by severe polyuria, due to the inability of the kidneys to concentrate urine in response to arginine vasopressin (AVP). In the majority of the cases, the disease shows an X-linked inherited pattern, although an autosomal recessive inheritance was also observed.

Methods: We report a patient with a severe NDI diagnosed during the neonatal period. Read More

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http://dx.doi.org/10.1002/mgg3.568DOI Listing
February 2019

Assessment and outcome of AV conduction in normal and anti-Ro/SSA antibody positive pregnancies evaluated by echocardiography and magnetocardiography.

Ultrasound Obstet Gynecol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Physics, The University of Wisconsin, Madison, WI.

Objectives: 1. Evaluate the association between echocardiographic AV and magnetocardiographic PR intervals at different gestational ages. 2. Read More

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http://dx.doi.org/10.1002/uog.20245DOI Listing
February 2019

Optogenetic Stimulation of the Anterior Cingulate Cortex Ameliorates Autistic-Like Behaviors in Rats Induced by Neonatal Isolation, Caudate Putamen as a Site for Alteration.

Neuromolecular Med 2019 Feb 19. Epub 2019 Feb 19.

Institute for Cognitive and Brain Science, Shahid Beheshti University, Tehran, Iran.

Epigenetic agents, such as neonatal isolation during neurodevelopmental period of life, can change various regions of the brain. It may further induce psychological disorders such as autistic-like phenomena. This study indicated the role of chronic increased anterior cingulate cortex (ACC) output on alteration of caudate putamen (CPu) as a main behavior regulator region of the brain in adult maternal deprived (MD) rats. Read More

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http://dx.doi.org/10.1007/s12017-019-08526-wDOI Listing
February 2019

Protracted postpartum urinary retention-a long-term problem or a transient condition?

Int Urogynecol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Obstetrics and Gynecology, the Edith Wolfson Medical Center, Holon, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Ha'Lochamim 62, PO Box 5, 58100, Holon, Israel.

Introduction And Hypothesis: Protracted postpartum urinary retention (P-PUR) is a rare puerperal complication of overt urinary retention that proceeds beyond the 3rd postpartum day. Long-term consequences of P-PUR are poorly reported. The objective of the study was to compare the long-term outcome of patients with P-PUR with a matched control group, using a validated pelvic floor distress questionnaire. Read More

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http://dx.doi.org/10.1007/s00192-019-03903-2DOI Listing
February 2019

Stridor in a Newborn with Double Aortic Arch-A Case Report.

Iran J Otorhinolaryngol 2019 Jan;31(102):61-63

Department of Otorhinolaryngology, Hospital Queen Elizabeth, Kota Kinabalu, Sabah, Malaysia.

Introduction: Double aortic arch (DAA) is a congenital anomaly of the aortic arch. It is the most common type of complete vascular ring. When it occurs, the connected segment of the aortic arch and its branches encircle the trachea and esophagus, leading to symptoms related to these two structures. Read More

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January 2019

Validation of the disposable T-piece resuscitator (Neo-Tee): a bench study.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 19. Epub 2019 Feb 19.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: The Neo-Tee Infant T-piece resuscitator is a disposable T-piece resuscitator. The aim of this bench study was to assess the accuracy of the Neo-Tee using a measurement set-up and settings mimicking clinical practice.

Study Design: Nine Neo-Tee devices were tested using a face mask interface and a manikin. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315298DOI Listing
February 2019

Safety and efficacy of 2% chlorhexidine gluconate aqueous versus 2% chlorhexidine gluconate in 70% isopropyl alcohol for skin disinfection prior to percutaneous central venous catheter insertion in preterm neonates: the ARCTIC randomised-controlled feasibility trial protocol.

BMJ Open 2019 Feb 19;9(2):e028022. Epub 2019 Feb 19.

Paediatric Infectious Diseases Research Group, Infection and Immunity, St George's University of London, London, UK.

Introduction: Catheter-related sepsis is one of the most dangerous complications of neonatal intensive care and is associated with significant morbidity and mortality. Use of catheter-care 'bundles' has reduced the incidence of catheter-related sepsis, although individual components have not been well studied. Better evidence is needed to guide selection of the most appropriate antiseptic solution for skin disinfection in preterm neonates. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028022DOI Listing
February 2019

Place-specific factors associated with adverse maternal and perinatal outcomes in Southern Mozambique: a retrospective cohort study.

BMJ Open 2019 Feb 19;9(2):e024042. Epub 2019 Feb 19.

Department of Medicine, Yale New Haven Health System, New Haven, Connecticut, USA.

Objectives: To identify and measure the place-specific determinants that are associated with adverse maternal and perinatal outcomes in the southern region of Mozambique.

Design: Retrospective cohort study. Choice of variables informed by literature and Delphi consensus. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024042DOI Listing
February 2019

Pregnancy outcomes of early detected gestational diabetes: a retrospective comparison cohort study, Qatar.

BMJ Open 2019 Feb 19;9(2):e023612. Epub 2019 Feb 19.

Department of Endocrinology, Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.

Objective: To compare pregnancy outcomes in patients with early versus usual gestational diabetes mellitus (GDM).

Design: A retrospective cohort study.

Settings: The Women's Hospital, Hamad Medical Corporation, Qatar. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023612DOI Listing
February 2019

Health facility service availability and readiness to provide basic emergency obstetric and newborn care in a low-resource setting: evidence from a Tanzania National Survey.

BMJ Open 2019 Feb 19;9(2):e020608. Epub 2019 Feb 19.

Department of Internal Medicine, College of Health Sciences, The University of Dodoma, Dodoma, United Republic of Tanzania.

Objective: This study used a nationally representative sample from Tanzania as an example of low-resource setting with a high burden of maternal and newborn deaths, to assess the availability and readiness of health facilities to provide basic emergency obstetric and newborn care (BEmONC) and its associated factors.

Design: Health facility-based cross-sectional survey.

Setting: We analysed data for obstetric and newborn care services obtained from the 2014-2015 Tanzania Service Provision Assessment survey, using WHO-Service Availability and Readiness Assessment tool. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-020608DOI Listing
February 2019

A prospective cohort for the investigation of alteration in temporal transcriptional and microbiome trajectories preceding preterm birth: a study protocol.

BMJ Open 2019 Jan 15;9(1):e023417. Epub 2019 Jan 15.

Sidra Medicine, Doha, Qatar.

Introduction: Preterm birth (PTB) results from heterogeneous influences and is a major contributor to neonatal mortality and morbidity that continues to have adverse effects on infants beyond the neonatal period. This protocol describes the procedures to determine molecular signatures predictive of PTB through high-frequency sampling during pregnancy, at delivery and the postpartum period.

Methods And Analysis: Four hundred first trimester pregnant women from either Myanmar or Thailand of either Karen or Burman ethnicity, with a viable, singleton pregnancy will be enrolled in this non-interventional, prospective pregnancy birth cohort study and will be followed through to the postpartum period. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023417DOI Listing
January 2019

Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: a population-based study.

BMJ Open 2019 Feb 1;9(1):e023004. Epub 2019 Feb 1.

Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.

Objective: After a decade of increase, the preterm birth (PTB) rate has declined in the USA since 2006, with the largest decline at late preterm (34-36 weeks). We described concomitant changes in gestational age-specific rates of neonatal mortality and morbidity following spontaneous and clinician-initiated PTB among singleton infants.

Design, Setting And Participants: This retrospective population-based study included 754 763 singleton births in Washington State, USA, 2004-2013, using data from birth certificates and hospitalisation records. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023004DOI Listing
February 2019

Hyperferritinaemia following intrauterine transfusions for Rh isoimmunisation.

BMJ Case Rep 2019 Feb 18;12(2). Epub 2019 Feb 18.

Neonatology Unit, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Intrauterine transfusion is one of the mainstays of treatment in isoimmunised pregnancies guided by the changes in middle cerebral artery Doppler of the fetus. The common postnatal complications associated with Rh isoimmunisation are high unconjugated bilirubin requiring blood exchange transfusions, cholestasis due to bile inspissation, thrombocytopenia and anaemia. Hyperferritinaemia is an uncommon adverse effect observed in Rh isoimmunised pregnancies. Read More

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http://dx.doi.org/10.1136/bcr-2018-227225DOI Listing
February 2019

Epilepsy surgery in the first months of life: a large type IIb focal cortical dysplasia causing neonatal drug-resistant epilepsy.

Epileptic Disord 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurosurgery, Section for Pediatric Neurosurgery, University of Ulm, Germany.

Focal cortical dysplasia is a common cause of medically refractory epilepsy in infancy and childhood. We report a neonate with seizures occurring within the first day of life. Continuous video-EEG monitoring led to detection of left motor seizures and a right frontal EEG seizure pattern. Read More

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http://dx.doi.org/10.1684/epd.2019.1037DOI Listing
February 2019

A novel mutation in KCNQ3-related benign familial neonatal epilepsy: electroclinical features and neurodevelopmental outcome.

Epileptic Disord 2019 Feb 18. Epub 2019 Feb 18.

Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro," University of Palermo, Palermo.

Benign familial neonatal epilepsy (BFNE) is caused, in about 5% of families, by mutations in the KCNQ3 gene encoding voltage-gated potassium channel subunits. Usually, newborns with BFNE show a normal neurological outcome, but recently, refractory seizures and/or developmental disability have been reported suggesting phenotype variability associated with KCNQ3-related BFNE. Here, we describe a proband from a BFNE family carrying a novel variant in the KCNQ3 gene. Read More

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http://dx.doi.org/10.1684/epd.2019.1030DOI Listing
February 2019

Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

Lancet 2019 Feb 14;393(10172):664-677. Epub 2019 Feb 14.

Anaesthesia and Pain Management Research Group, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia; Department of Anaesthesia and Pain Management, The Royal Children's Hospital, Melbourne, VIC, Australia. Electronic address:

Background: In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have found no evidence for an association. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32485-1DOI Listing
February 2019

[Effect of calcium-sensitive receptors on endothelial nitric oxide synthase and nitric oxide in neonatal mice with persistent pulmonary hypertension].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):189-194

Department of Pediatrics, First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832000, China.

Objective: To study the effect of calcium-sensitive receptors (CaSR) on the expression of endothelial nitric oxide synthase (eNOS) and the concentration of nitric oxide (NO) in a neonatal mouse model of persistent pulmonary hypertension (PPH).

Methods: Eighty neonatal C57BL/6 mice were randomly divided into control, PPH, agonist and antagonist groups. The control group was exposed to air, and the other three groups were exposed to 12% oxygen. Read More

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February 2019

[Distribution of peripheral blood lymphocyte subsets in 826 healthy children aged 0-6 years].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):180-183

Medical Genetics Center, Guangdong Women and Children's Hospital, Guangzhou 511442, China.

Objective: To study the distribution of peripheral blood lymphocyte subsets in healthy children aged 0-6 years.

Methods: A total of 826 healthy Han children aged 0-6 years were recruited. According to their age, the children were divided into four groups: newborn, infant, toddler and preschool. Read More

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February 2019

[A case report of EIF2AK3-related Wolcott-Rallison syndrome and literature review].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):176-179

Pediatric Intensive Care Unit, Fujian Provincial Maternity and Child Care Center Affiliated to Fujian Medical University, Fuzhou 350001, China.

The patient was a female infant aged 1 month and 29 days. She was admitted to the hospital due to convulsions for 6 days and increased blood glucose level for 5 days. She had unstable blood glucose levels. Read More

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February 2019

[Expression of high-mobility group box 1 in neonates with sepsis].

Authors:
Su-Yan Zhuo Li Liao

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):131-138

Department of Pediatrics, People's Hospital of Chongqing Shapingba District, Chongqing 400030, China.

Objective: To study the expression of high-mobility group box 1 (HMGB1) in neonates with sepsis and its role in the pathogenesis of neonatal sepsis.

Methods: A total of 62 neonates with sepsis were enrolled as the sepsis group, 66 neonates with local infection were enrolled as the local infection group, and 70 healthy neonates were enrolled as the healthy control group. Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-17 (IL-17), interleukin-23 (IL-23), C-reactive protein (CRP) and procalcitonin (PCT) were measured. Read More

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February 2019
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[A multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):114-119

Department of Neonatology, Anhui Provincial Children's Hospital, Hefei 230051, China.

Objective: To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China.

Methods: Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants. Read More

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February 2019

[Guideline on lung ultrasound to diagnose pulmonary diseases in newborn infants].

Authors:

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):105-113

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February 2019

Epigenetic impacts of maternal tobacco and e-vapour exposure on the offspring lung.

Clin Epigenetics 2019 Feb 19;11(1):32. Epub 2019 Feb 19.

Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, Australia.

In utero exposure to tobacco products, whether maternal or environmental, have harmful effects on first neonatal and later adult respiratory outcomes. These effects have been shown to persist across subsequent generations, regardless of the offsprings' smoking habits. Established epigenetic modifications induced by in utero exposure are postulated as the mechanism underlying the inherited poor respiratory outcomes. Read More

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http://dx.doi.org/10.1186/s13148-019-0631-3DOI Listing
February 2019

The SURV1VE trial-sustained inflation and chest compression versus 3:1 chest compression-to-ventilation ratio during cardiopulmonary resuscitation of asphyxiated newborns: study protocol for a cluster randomized controlled trial.

Trials 2019 Feb 19;20(1):139. Epub 2019 Feb 19.

Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, 10240 Kingsway Avenue NW, Edmonton, AB, T5H 3V9, Canada.

Background: The need for cardiopulmonary resuscitation (CPR) is often unexpected, and the infrequent use of CPR in the delivery room (DR) limits the opportunity to perform rigorous clinical studies to determine the best method for delivering chest compression (CC) to newborn infants. The current neonatal resuscitation guidelines recommend using a coordinated 3:1 compression-to-ventilation (C:V) ratio (CC at a rate of 90/min and ventilations at a rate of 30/min). In comparison, providing CC during a sustained inflation (SI) (CC + SI) significantly improved hemodynamics, minute ventilation, and time to return of spontaneous circulation (ROSC) compared to 3:1 C:V ratio in asphyxiated piglets. Read More

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http://dx.doi.org/10.1186/s13063-019-3240-8DOI Listing
February 2019

Review of evidence based clinical practice guidelines developed in Latin America and Caribbean during the last decade: an analysis of the methods for grading quality of evidence and topic prioritization.

Global Health 2019 Feb 19;15(1):14. Epub 2019 Feb 19.

Clinical Research Institute and Health Technology Assessment Unit, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá D.C., Colombia.

Background: In the last decade, efforts have been made in Latin America and the Caribbean to advance in the methodological development of evidence based clinical practice guidelines, among other strategies to improve the health provision of services and indicators.

Objectives: To build an evidence map to show the regional GRADE impact in developing clinical practice guidelines and contrast the results with current needs.

Methods: A systematic literature search was conducted in databases, developer's websites, health ministries, repositories and grey literature. Read More

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http://dx.doi.org/10.1186/s12992-019-0455-0DOI Listing
February 2019

Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.

BMC Med 2019 Feb 20;17(1):42. Epub 2019 Feb 20.

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China.

Background: Cathelicidins are a major group of natural antimicrobial peptides which play essential roles in regulating host defense and immunity. In addition to the antimicrobial and immunomodulatory activities, recent studies have reported the involvement of cathelicidins in cardiovascular diseases by regulating inflammatory response and microvascular dysfunction. However, the role of cathelicidins in myocardial apoptosis upon cardiac ischemia/reperfusion (I/R) injury remains largely unknown. Read More

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http://dx.doi.org/10.1186/s12916-019-1268-yDOI Listing
February 2019

Predictors for cesarean delivery in preterm premature rupture of membranes.

J Matern Fetal Neonatal Med 2019 Feb 19:1-131. Epub 2019 Feb 19.

c Hillel Yaffe Medical Center , The Rappaport faculty of Medicine , Technion , Hadera , Haifa , Israel.

Objective: To determine predictors for cesarean delivery (CD) in pregnancies complicated by preterm premature rupture of membranes (PPROM) with an intention for vaginal delivery.

Materials And Methods: A retrospective cohort analysis of all singleton, preterm deliveries (24 + 0 to 36 + 6 weeks) following PPROM (2007-2014). Exclusion criteria included: cases intended for CD prior to delivery; short interval from PPROM to delivery (< 24 hours); cervical dilatation upon admission ≥ 4 cm; and major fetal anatomical/chromosomal abnormalities. Read More

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http://dx.doi.org/10.1080/14767058.2019.1585422DOI Listing
February 2019

Intrapartum ultrasound monitoring of malposition and malrotation during labor neuraxial analgesia: maternal outcomes.

J Matern Fetal Neonatal Med 2019 Feb 19:1-7. Epub 2019 Feb 19.

e Anesthesiology and Obstetrics and Gynecology , Texas Tech University Health Sciences Center at El Paso , El Paso , TX , USA.

Objective: This study analyzes the important role of ultrasonography (IUS) related to the maternal outcomes in women with fetal persistent occiput posterior position (POPP) and asynclitism (A) in labor neuraxial analgesia (LNA).

Study Design: Prospective assessment of 148 primiparous women diagnosed with the prolonged second stage of labor. Transabdominal and transperineal IUS were used to detect fetal head position and to evaluate the angle of progression (AOP) and pubic arch angle (PAA). Read More

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http://dx.doi.org/10.1080/14767058.2019.1579193DOI Listing
February 2019

Gynecomastia: incidence, causes and treatment.

Expert Rev Endocrinol Metab 2011 Sep;6(5):723-730

a Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.

Gynecomastia is a benign proliferation of glandular tissue of the breast in males. It is common during three phases in the age distribution curve: the neonatal period, puberty and senescence. An imbalance between estrogen and androgen action at the level of breast tissue is believed to be the underlying pathophysiology. Read More

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http://dx.doi.org/10.1586/eem.11.57DOI Listing
September 2011

Thyroid dysfunction in pregnancy: optimizing fetal and maternal outcomes.

Expert Rev Endocrinol Metab 2010 Jul;5(4):521-529

b Centre for Endocrine and Diabetes Sciences, School of Medicine, Cardiff University, Cardiff CF14 4XN, South Wales, UK.

Recent decades have seen a growing awareness of the threat posed by thyroid dysfunction in pregnancy on maternal, fetal and neonatal well-being. Uncontrolled hypothyroidism and hyperthyroidism are associated with adverse obstetrics and fetal outcomes and also affect neurointellectual development in the offspring. Excellent outcomes are, however, achievable with appropriate management. Read More

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http://dx.doi.org/10.1586/eem.10.30DOI Listing
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