705,081 results match your criteria Neonatal Paediatric and Child Health Nursing [Journal]


Maternal Glycemic Control in Type 1 Diabetes and the Risk for Preterm Birth: A Population-Based Cohort Study.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Karolinska Institutet, Stockholm, Sweden, and Statens Serum Institut, Copenhagen, Denmark (B.P.).

Background: Maternal type 1 diabetes (T1D) has been linked to preterm birth and other adverse pregnancy outcomes. How these risks vary with glycated hemoglobin (or hemoglobin A1c [HbA1c]) levels is unclear.

Objective: To examine preterm birth risk according to periconceptional HbA1c levels in women with T1D. Read More

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http://dx.doi.org/10.7326/M18-1974DOI Listing

Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition.

Behav Brain Res 2019 Apr 19:111921. Epub 2019 Apr 19.

Johns Hopkins University (JHU), Department of Anesthesiology and Critical Care Medicine, Baltimore, MD, United States. Electronic address:

Neonatal brain injury from hypoxia-ischemia (HI) causes major morbidity. Piglet HI is an established method for testing neuroprotective treatments in large, gyrencephalic brain. Though many neurobehavior tests exist for rodents, such tests and their associations with neuropathologic injury remain underdeveloped and underutilized in large, neonatal HI animal models. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.111921DOI Listing

Neonatal screening tests in Brazil: prevalence rates and regional and socioeconomic inequalities.

J Pediatr (Rio J) 2019 Apr 19. Epub 2019 Apr 19.

Universidade Federal de Santa Catarina (UFSC), Departamento de Saúde Pública, Florianópolis, SC, Brazil. Electronic address:

Objective: To identify the prevalence and associated factors with the performance of the Guthrie test, hearing, and red reflex screening tests in Brazil.

Methods: This was a population-based, cross-sectional study that analyzed data on 5231 children under 2 years of age participating in the National Health Survey of 2013. The study described the prevalence and confidence intervals (95% CI) of the three neonatal screening tests performed, in any period, and their association with the country's regions, skin color/ethnicity, private health insurance, and per capita household income. Read More

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http://dx.doi.org/10.1016/j.jped.2019.02.008DOI Listing

Effect of timing of umbilical cord clamping on maternal and neonatal outcomes: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15283

Department of Nursing, The First Hospital of Lanzhou University, Gansu Province, China.

Background: Umbilical cord clamping is one of the most commonly used medical or complementary medical interventions. The different timing of cord clamping may have any significant impact on public health. However, the results remain controversial. Read More

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http://dx.doi.org/10.1097/MD.0000000000015283DOI Listing
April 2019
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Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Pain 2019 05;160(5):1059-1069

Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
May 2019
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Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.

Anesthesiology 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

What We Already Know About This Topic: Opioid-induced respiratory depression results in part from direct activation of μ-opioid receptors expressed in the inspiratory rhythm generator located in the ventrolateral medulla, the preBötzinger ComplexRespiratory neurons within the medulla also express nicotinic acetylcholine receptors, which are made up of five subunits, arranged symmetrically around a central poreActivation of the nicotinic acetylcholine receptor α4, α7, and β2 subunits increases respiratory rhythm, whereas activation of the nicotinic acetylcholine receptor α4β2 or α7 subunits induces analgesia in multiple forms of pain WHAT THIS ARTICLE TELLS US THAT IS NEW: The nonselective nicotinic acetylcholine receptor agonist nicotine and the α4β2 nicotinic acetylcholine receptor agonist A85380, but not the α7 nicotinic acetylcholine receptor agonist PNU282987, reversed respiratory depression induced by activation of μ-opioid receptors in rats both in vitro and in vivoCoadministration of A85380 with fentanyl not only markedly reduced respiratory depression and apneas but also enhanced the fentanyl-induced analgesia BACKGROUND:: Opioid analgesics are widely used for treatment of acute, postoperative, and chronic pain. However, activation of opioid receptors can result in severe respiratory depression. There is an unmet clinical need to develop a pharmacologic therapy to counter opioid-induced respiratory depression without interfering with analgesia. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002676DOI Listing

Patients' and Doctors' Perceptions of a Mobile Phone-Based Consultation Service for Maternal, Neonatal, and Infant Health Care in Bangladesh: A Mixed-Methods Study.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e11842. Epub 2019 Apr 22.

National Centre for Epidemiology and Population Health, Research School of Population Health, The Australian National University, Canberra, Australia.

Background: A mobile-based consultation service, or telehealth, can be used for remote consultations with health care professionals for screening, self-care management, and referral. In rural Bangladesh, where there is high demand for scarce male and even scarcer female doctors, remote consultations may help women seeking maternal and child health care. Aponjon is a mHealth service in Bangladesh that provides weekly voice or text messages to pregnant women, new mothers, and family members on various aspects of maternal, neonatal, and infant health. Read More

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http://dx.doi.org/10.2196/11842DOI Listing
April 2019
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One year outcome of high-risk newborn infants discharged from the neonatal care unit of the National Maternal and Child Health Center in Cambodia.

Heliyon 2019 Apr 9;5(4):e01446. Epub 2019 Apr 9.

Bureau of International Health Cooperation, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan.

Background: In the National Maternal and Child Health Center in Cambodia, about 7,500 newborn infants are born every year. Around 10% of them are admitted to the neonatal care unit. After recovery from the acute phase that presented neonatal care unit admissions, they are discharged even if they are very low birth weight infants, but there is no official follow-up system available after discharge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183210
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http://dx.doi.org/10.1016/j.heliyon.2019.e01446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458445PMC
April 2019
1 Read

Managing Infants Exposed to Maternal Chorioamnionitis by the Use of Early-Onset Sepsis Calculator.

Glob Pediatr Health 2019 8;6:2333794X19833711. Epub 2019 Apr 8.

Hennepin County Medical Center, Minneapolis, MN, USA.

. To reduce neonatal intensive care unit admission rate (NAR) and antibiotic utilization rate (AUR) in ≥36 weeks gestational age infants exposed to maternal chorioamnionitis (MC) through the application of early-onset sepsis calculator (EOSCAL). . Read More

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http://dx.doi.org/10.1177/2333794X19833711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457026PMC

A stitched jaw in the newborn: subglosso-palatal membrane.

Pan Afr Med J 2018 3;31:80. Epub 2018 Oct 3.

Department of Pediatrics, Division of Neonatology, University of Health Sciences, Bursa Yüksek Ihtisas Teaching Hospital, Bursa, Turkey.

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http://www.panafrican-med-journal.com/content/article/31/80/
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http://dx.doi.org/10.11604/pamj.2018.31.80.16591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457719PMC
October 2018
1 Read

Is prone sleeping dangerous for neonates? Polysomnographic characteristics and NDN gene analysis.

Ci Ji Yi Xue Za Zhi 2019 Apr-Jun;31(2):113-117

Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Objective: Prone sleep is an identified risk factor for sudden infant death syndrome, possibly due to reduced blood pressure, cerebral oxygenation, and impaired cerebral vascular control. Cardiac and respiratory responses in neonates during supine and prone sleep have not been reported.

Materials And Methods: In this study, daytime polysomnography (PSG) data from 17 neonates aged 2-3 days during supine and prone sleep were reported and the NDN gene, an important gene for neonatal respiratory control, was sequenced for correlation with neonatal respiratory parameters. Read More

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http://www.tcmjmed.com/text.asp?2019/31/2/113/236553
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http://dx.doi.org/10.4103/tcmj.tcmj_29_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450148PMC
April 2019
1 Read

Clinical and ultrasonographic parameters in assessment of labor induction success in nulliparous women.

J Matern Fetal Neonatal Med 2019 Apr 21:1-8. Epub 2019 Apr 21.

a Clinic of Obstetrics and Gynecology , Clinical Center of Serbia , Belgrade , Serbia.

Purpose: Evaluation of simplified Bishop score and ultrasound cervicometry in the assessment of labor induction success in nulliparous women.

Methods: Prospective cohort study included 146 nulliparous women with singleton pregnancy and indications for labor induction. Prior to labor induction, cervicometry and Bishop score were determined. Read More

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http://dx.doi.org/10.1080/14767058.2019.1594185DOI Listing

Association between glycated haemoglobin, glycated albumin and fructosamine with neonatal birthweight and large-for-date status infants in gestational diabetes mellitus: a prospective cohort study.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Maternal-Fetal Medicine , Central Lisbon Hospital Center , Lisbon , Portugal.

This study aims to investigate associations between glycated haemoglobin (HbA1c), glycated albumin (GA) and fructosamine with neonatal birthweight in gestational diabetes mellitus (GDM). The prospective cohort consisted of 82 women with GDM and their newborns, enrolled between November 2016 and September 2017. Considering neonatal birthweight and birthweights ≥90th percentile for gestational age as outcomes, linear and logistic regression models were used, respectively. Read More

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http://dx.doi.org/10.1080/01443615.2019.1584886DOI Listing

A comparative in vitro study of standard facemask jet nebulization and high-flow nebulization in bronchiolitis.

Exp Lung Res 2019 Apr 22:1-9. Epub 2019 Apr 22.

c Chemical Engineering Division, Department of Biotechnology and Food Science , Universidad de Burgos , Burgos , Spain.

Aim Of Study: The use of a nebulizer paired with high-flow nasal cannulas (HFNC) has been proposed for drug delivery in bronchiolitis. Particle size nebulized is a relevant factor determining the efficacy of the nebulization. We replicated in vitro the theoretical parameters most widely used in bronchiolitis and we compared the size of the droplet nebulized with a standard nebulizer and a nebulizer integrated into HFNC. Read More

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https://www.tandfonline.com/doi/full/10.1080/01902148.2019.1
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http://dx.doi.org/10.1080/01902148.2019.1599084DOI Listing
April 2019
1 Read

Prediction of adverse perinatal outcomes by fetal biometry: a comparison of customized and population-based standards.

Ultrasound Obstet Gynecol 2019 Apr 22. Epub 2019 Apr 22.

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS).

Objective: To compare the predictive ability of estimated fetal weight (EFW) percentiles, according to seven growth standards, to detect fetuses at risk for adverse perinatal outcomes.

Methods: This retrospective cohort study included 3,437 African-American women. Population-based (Hadlock, INTERGROWTH-21st, WHO, FMF), ethnic specific (NICHD), customized (GROW) and African American customized (PRB/NICHD) growth standards were applied to the last available scan prior to delivery. Read More

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http://dx.doi.org/10.1002/uog.20299DOI Listing

Opioids: A Review of Pharmacokinetics and Pharmacodynamics in Neonates, Infants, and Children.

Eur J Drug Metab Pharmacokinet 2019 Apr 22. Epub 2019 Apr 22.

Department of Pharmaceutical Sciences, Gatton College of Pharmacy, East Tennessee State University, Box 70594, Johnson City, TN, 37614-1708, USA.

Pain management in the pediatric population is complex for many reasons. Mild pain is usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more severe pain often require the use of an opioid, which may be administered by many different routes, depending on clinical necessity. Read More

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http://dx.doi.org/10.1007/s13318-019-00552-0DOI Listing
April 2019
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Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Nutrition Department.

Background: Infancy is a crucial period for establishing the intestinal microbiome. This process may be influenced by vitamin A (VA) status because VA affects intestinal immunity and epithelial integrity, factors that can, in turn, modulate microbiome development.

Objectives: The aim of this study was to determine if neonatal VA supplementation (VAS) affected the abundance of Bifidobacterium, a beneficial commensal, or of Proteobacteria, a phylum containing enteric pathogens, in early (6-15 wk) or late (2 y) infancy. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxz034DOI Listing
April 2019
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Association between Tumor Necrosis Factor-α Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants.

Tohoku J Exp Med 2019 ;247(4):259-264

Institute of Human Genetics, Faculty of Medicine, University of Belgrade.

Early-onset neonatal sepsis (EOS) is diagnosed during the first 7 days of neonatal life and is the major cause of morbidity and mortality among preterm infants. Genetic predisposition may have an impact on EOS susceptibility and outcome. The aim of our study was to explore the association between TNF-α -308 G/A or IL-6 -174 G/C gene polymorphism and the susceptibility and outcome of EOS in preterm infants. Read More

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http://dx.doi.org/10.1620/tjem.247.259DOI Listing
January 2019

Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice.

Acta Histochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Second Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China. Electronic address:

Sevoflurane is a widely used inhaled anesthetic, which triggers neuroapoptosis and oxidative damage in the developing central nervous system and cognitive dysfunction later in life. However, no effective therapeutic strategy for sevoflurane-induced deleterious effects is well developed. The purpose of the present study was to explore whether luteoline could attenuate neonatal sevoflurane exposure-triggered neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.04.004DOI Listing

CCR4-NOT transcription complex, subunit 1 (CNOT1) Variant Associated with Holoprosencephaly.

Am J Hum Genet 2019 Apr 5. Epub 2019 Apr 5.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Holoprosencephaly is the incomplete separation of the forebrain during embryogenesis. Both genetic and environmental etiologies have been determined for holoprosencephaly; however, a genetic etiology is not found in most cases. In this report, we present two unrelated individuals with semilobar holoprosencephaly who have the identical de novo missense variant in the gene CCR4-NOT transcription complex, subunit 1 (CNOT1). Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.03.017DOI Listing

A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

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https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
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http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
1 Read

Understanding Barriers to Uptake of 17 alpha-hydroxyprogesterone caproate (17-OHP) in Women with History of preterm Birth.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

e Denver Health and Hospital Authority , Women's Care Clinic , Denver , Colorado , USA.

Background: Premature birth is responsible for approximately 38% of infant deaths as well as a host of complications, including abnormal lung development, infection, and long-term disabilities. For women with a history of spontaneous preterm birth in a singleton pregnancy, use of 17 alpha-hydroxyprogesterone caproate (17-OHP) can reduce the risk of a recurrent preterm birth by up to 42%. However, less than half of eligible women currently receive 17-OHP. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610736DOI Listing

Low grade intraventricular hemorrhage of preterm infants: neurodevelopmental and motor outcome.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a National and Kapodistrian University of Athens , Medical School , Athens , Greece.

Intraventricular hemorrhage (IVH) is a main complication of prematurity, inversely associated with gestational age and birth weight. Low-grade IVH (I and II), diagnosed by cranial ultrasound, had long been considered rather not to affect neurodevelopmental and motor outcome, a view challenged by several literature reports. However, diversity in studies design, periods of subjects' collection, cohort characteristics, demographic data, maternal or neonatal comorbidities, neuroimaging methods, evaluation tools, short-or-long-term follow-up by the same or different examiners, as well as other parameters and confounders make comparisons among reports very difficult, not allowing solid conclusions. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610741DOI Listing

Gasdermin D: in vivo evidence of pyroptosis in spontaneous labor at term.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a Perinatology Research Branch , Division of Obstetrics and Maternal Fetal Medicine , Division of Intramural Research , Eunice Kennedy Shriver National Institute of Child Health and Human Development , National Institutes of Health , U. S. Department of Health and Human Services , Bethesda , Maryland, and Detroit, Michigan, USA.

Objective: Pyroptosis is an inflammatory form of programed cell death that is mediated by the activation of the inflammasome and depends on the pore-forming function of gasdermin D. Therefore, the detection of gasdermin D represents in vivo evidence of pyroptosis. We recently showed that there is intra-amniotic inflammasome activation in spontaneous labor at term; however, evidence of pyroptosis is lacking. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610740DOI Listing

Ultrasonographic vascularity assessment for predicting future severe hemorrhage in retained products of conception after second-trimester abortion.

J Matern Fetal Neonatal Med 2019 Apr 21:1-11. Epub 2019 Apr 21.

a Department of Obstetrics and Gynecology , Faculty of Medicine , the University of Tokyo , Tokyo , Japan.

Objectives: To investigate the spontaneous outcomes of vascularized retained products of conception (RPOC) detected by ultrasonography after second-trimester abortion, and to identify the predictive factors for the development of severe postpartum hemorrhage (SPPH).

Study Design: This is a retrospective cohort study on all cases after second-trimester abortion managed at our institute between January 2014 and December 2016. We assessed the associations between the occurrence of SPPH requiring invasive treatment and clinical factors including ultrasonographic findings (size and the vascularity status of RPOC classified as follows; type1: vascularity confined to endometrium, type2: vascularity reaching < 1/2 myometrium, type3: vascularity reaching ≥ 1/2 myometrium) in vascularized RPOC cases. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610739DOI Listing

A key developmental step for preterm babies: achievement of full oral feeding.

J Matern Fetal Neonatal Med 2019 Apr 21:1-191. Epub 2019 Apr 21.

f Istituto Giannina Gaslini, Neonatal Intensive Care Unit , Genova , Italy.

Aims: To investigate timing of oral feeding (OF) introduction and full oral feeding (FOF) achievement in preterm infants and to explore factors associated with feeding progression.

Methods: Retrospective review of 100 medical records of preterms ≤ 32 weeks of gestation (GA) without major complication. Outcome measures were timing of OF introduction, transition time from nasogastric tube to FOF and FOF achievement. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1610733DOI Listing

Maternal periconceptional body mass index and risk for neural tube defects: results from a large cohort study in China.

J Matern Fetal Neonatal Med 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Institute of Reproductive and Child Health , Peking University/Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China , Beijing , P. R. China.

Background: Case-control studies have consistently suggested an association between pre- or periconceptional maternal obesity and an increased risk for neural tube defects (NTDs). Few studies have examined the association between body mass index (BMI) and NTDs using measured weight and height. We examined this association in a large cohort study in China. Read More

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http://dx.doi.org/10.1080/14767058.2019.1606192DOI Listing

Use of gestational surrogates for women with Eisenmenger syndrome: a cost-effectiveness analysis.

J Matern Fetal Neonatal Med 2019 Apr 21:1-181. Epub 2019 Apr 21.

a Department of Obstetrics & Gynecology , Oregon Health & Sciences University , Portland , Oregon , USA.

Objective: Eisenmenger syndrome is regarded as a contraindication to pregnancy, with therapeutic abortion recommended in the event of unintended pregnancy. However, women with Eisenmenger syndrome continue to desire and attempt pregnancy despite grave risks to their own health. This study compares the costs and outcomes of pregnancy in women with Eisenmenger syndrome to the use of gestational surrogates in their pregnancies. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1610734DOI Listing
April 2019
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Oral misoprostol for induction of labour at term: A randomized controlled trial of hourly titrated and 2 hourly static oral misoprostol solution.

J Matern Fetal Neonatal Med 2019 Apr 21:1-211. Epub 2019 Apr 21.

c Department of Medical Social Services , Ekiti State University Teaching Hospital , Ado-Ekiti , Nigeria.

Background: Misoprostol has been shown to be effective in induction of labour (IOL) with different dosages and routes of administration.

Objectives: This study compared the efficacy and safety of hourly titrated and 2-hourly static low dose oral misoprostol for IOL in Ekiti State University Teaching Hospital, Ado-Ekiti.

Methods: One hundred fifty women with singleton pregnancy at term admitted for IOL were randomized into the two groups. Read More

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http://dx.doi.org/10.1080/14767058.2019.1610378DOI Listing

The Swedish Neonatal Quality Register (SNQ) - contents, completeness and validity.

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Swedish Neonatal Quality Register (SNQ).

Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.

Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined crosslinking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years. Read More

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http://dx.doi.org/10.1111/apa.14823DOI Listing

Infant carrying by a wild chimpanzee father at Bulindi, Uganda.

Primates 2019 Apr 20. Epub 2019 Apr 20.

Department of Social Sciences, Faculty of Humanities and Social Sciences, Oxford Brookes University, Oxford, UK.

Although infanticide by wild adult male chimpanzees has been reported from multiple sites, affiliative infant carrying by males is rare. We observed infant carrying by an alpha male chimpanzee at Bulindi (Uganda) on two consecutive mornings and collected faecal samples from the newborn infant female, her mother and all candidate fathers to determine whether the alpha male was the infant's father using a likelihood-based method of paternity assignment. In contrast to previous observations of male care of orphans, in this case the mother was present during observations. Read More

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http://dx.doi.org/10.1007/s10329-019-00726-zDOI Listing
April 2019
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Role of Vitamin-D Deficiency in Term Neonates with Late-Onset Sepsis: A Case-Control Study.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Department of Pediatrics, Gandhi Medical College, Hamidia Hospital, Bhopal, Madhya Pradesh 462030, India.

Objective: To find the relationship between vitamin-D levels and late-onset sepsis (LOS) in term neonates.

Methods: This case-control study was conducted in neonatal intensive care unit of a tertiary care teaching institution in central India. Full-term neonates with culture-proven LOS were taken as cases. Read More

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http://dx.doi.org/10.1093/tropej/fmz021DOI Listing

Screening and treatment to reduce severe hyperbilirubinaemia in infants in primary care (STARSHIP): a factorial stepped-wedge cluster randomised controlled trial protocol.

BMJ Open 2019 Apr 20;9(4):e028270. Epub 2019 Apr 20.

Division of Neonatology, Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, Netherlands.

Introduction: Jaundice caused by hyperbilirubinaemia is a physiological phenomenon in the neonatal period. However, severe hyperbilirubinaemia, when left untreated, may cause kernicterus, a severe condition resulting in lifelong neurological disabilities. Although commonly applied, visual inspection is ineffective in identifying severe hyperbilirubinaemia. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028270DOI Listing

The effectiveness of a parent participation improvement program for parents on partnership, attachment infant growth in a neonatal intensive care unit: A randomized controlled trial.

Int J Nurs Stud 2019 Apr 2;95:19-27. Epub 2019 Apr 2.

Institutional Address: College of Nursing, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:

Background: Parent participation based on collaboration with nurses is recognized as an important concept in neonatal care. However, there is a lack of research providing specific strategies to promote parent participation in clinical activities, and there are few studies including both mothers and fathers.

Objectives: The purpose of this study was to develop a Parent Participation Improvement Program for parents in neonatal intensive care units, and to evaluate its effects on parents' partnerships with nurses, attachment to infants, and infants' body weight. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2019.03.018DOI Listing

At the Forefront of Psychoneuroimmunology in Pregnancy: Implications for Racial Disparities in Birth Outcomes PART 1: Behavioral Risks Factors.

Authors:
Lisa M Christian

Neurosci Biobehav Rev 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychiatry & Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; The Institute for Behavioral Medicine Research, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA; Department of Psychology, The Ohio State University, Columbus, Ohio, USA; Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

Birth prior to full term is a substantial public health issue. In the US, ˜400,000 babies per year are born preterm (< 37 weeks), while >1 million are early term (37-38 weeks). Birth prior to full term confers risk both immediate and long term, including neonatal intensive care, decrements in school performance, and increased mortality risk from infancy through young adulthood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01497634193033
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http://dx.doi.org/10.1016/j.neubiorev.2019.04.009DOI Listing
April 2019
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White Matter Lesions Detected by Magnetic Resonance Imaging in Neonates and Children With Congenital Myotonic Dystrophy.

Pediatr Neurol 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; University of Cincinnati, College of Medicine, Cincinnati, Ohio. Electronic address:

Background: Congenital myotonic dystrophy (CDM1) is an autosomal dominant genetic disorder caused by abnormal cytosine-thymine-guanine trinucleotide repeat expansion that results in weakness and cognitive deficits. Studies detailing brain magnetic resonance imaging (MRI) findings in neonates and children with this condition are limited.

Objective: We evaluated the brain MRI findings in children, including neonates with CDM1, to assess the nature of central nervous system involvement and progression of MRI lesions over time. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183114
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http://dx.doi.org/10.1016/j.pediatrneurol.2019.03.004DOI Listing
March 2019
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Post-cesarean delivery pain. Management of the opioid-dependent patient before, during and after cesarean delivery.

Authors:
R Landau

Int J Obstet Anesth 2019 Feb 10. Epub 2019 Feb 10.

Virginia Apgar Professor of Anesthesiology, Department of Anesthesiology, Columbia University Medical Center, Columbia University College of Physicians & Surgeons, New York, United States. Electronic address:

The opioid crisis has reached an unprecedented magnitude in the United States and worldwide, and data on opioid use and misuse in the obstetric population are extremely concerning. Despite an abundant number of studies evaluating strategies to prevent neonatal opioid withdrawal syndrome mothers who are chronic opioid users, in babies born to mothers using chronic opioids, numerous questions remain unanswered, including (1) how to optimally manage postpartum pain in opioid-dependent patients (2) how to reconcile buprenorphine and methadone use with intrapartum and postpartum analgesia, so as to avoid opioid withdrawal during and after delivery (3) how to safely and effectively provide a stepwise multimodal approach that incorporates systemic opioid-sparing approaches, such as neuraxial opioids, clonidine, ketamine, gabapentin, and regional anesthetic blocks, to ensure adequate pain relief while avoiding opioid withdrawal (4) how to optimally manage postpartum recovery and (5) how to avoid excessive opioid prescription and possibly left-over opioids that may promote persistent use, misuse and diversion. With the recognition that an increasing number of pregnant women are taking chronic opioids, the goals of this review article are to summarize the existing literature on post-cesarean pain management in the obstetric patient with an opioid-use disorder; and to provide clinicians with a stepwise approach for management before, as well as during and after, cesarean delivery of women who have been chronically using opioids during their pregnancy. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.011DOI Listing
February 2019

Trends of antenatal care during pregnancy in low- and middle-income countries: Findings from the global network maternal and newborn health registry.

Semin Perinatol 2019 Mar 16. Epub 2019 Mar 16.

Columbia University, New York, NY, United States.

Background: Antenatal care (ANC) is an important opportunity to diagnose and treat pregnancy-related complications and to deliver interventions aimed at improving health and survival of both mother and the infant. Multiple individual studies and national surveys have assessed antenatal care utilization at a single point in time across different countries, but ANC trends have not often been studied in rural areas of low-middle income countries (LMICs). The objective of this analysis was to study the trends of antenatal care use in LMICs over a seven-year period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005193004
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http://dx.doi.org/10.1053/j.semperi.2019.03.020DOI Listing
March 2019
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Physiological and behavioral responses as indicators for early disease detection in dairy calves.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

InterAg, Ruakura Research Centre, Hamilton 3214, New Zealand.

This study investigated physiological and behavioral responses associated with the onset of neonatal calf diarrhea (NCD) in calves experimentally infected with rotavirus and assessed the suitability of these responses as early disease indicators. The suitability of infrared thermography (IRT) as a noninvasive, automated method for early disease detection was also assessed. Forty-three calves either (1) were experimentally infected with rotavirus (n = 20) or (2) acted as uninfected controls (n = 23). Read More

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http://dx.doi.org/10.3168/jds.2018-15701DOI Listing

Transcriptome profiling reveals activation of inflammation and apoptosis in the neonatal striatum after deep hypothermic circulatory arrest.

J Thorac Cardiovasc Surg 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiovascular Surgery, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Objectives: Brain injury, leading to long-term neurodevelopmental deficits, is a major complication in neonates undergoing cardiac surgeries. Because the striatum is one of the most vulnerable brain regions, we used mRNA sequencing to unbiasedly identify transcriptional changes in the striatum after cardiopulmonary bypass and associated deep hypothermic circulatory arrest.

Methods: Piglets were subjected to cardiopulmonary bypass with deep hypothermic circulatory arrest at 18°C for 30 minutes and then recovered for 6 hours. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00225223193055
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http://dx.doi.org/10.1016/j.jtcvs.2019.02.091DOI Listing
March 2019
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Intracranial Mycotic Aneurysm Complicating Streptococcus pneumoniae Infection.

J Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Children's Hospital of Wisconsin, Milwaukee, Wisconsin; Division of Infectious Disease, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1016/j.jpeds.2019.03.031DOI Listing

Association of Center-Specific Patient Volumes and Early Respiratory Management Practices with Death and Bronchopulmonary Dysplasia in Preterm Infants.

J Pediatr 2019 Apr 17. Epub 2019 Apr 17.

Department of Pediatrics, Royal Hobart Hospital, Hobart, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Objectives: To describe variability in admission volumes and approach to early respiratory support between neonatal intensive care units in the Australian and New Zealand Neonatal Network and to evaluate whether these center-specific factors are associated with death and bronchopulmonary dysplasia.

Study Design: This retrospective cohort study included 19 099 neonates born between 25 and 32 weeks' gestation and admitted to 1 of 25 NICUs from 2007 to 2013. Center-specific factors evaluated were annual admission volume and rate of using continuous positive airway pressure (CPAP) rather than intubation as the first mode of respiratory support. Read More

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http://dx.doi.org/10.1016/j.jpeds.2019.02.036DOI Listing

Alterations in Cortical Morphology after Neonatal Stroke: Compensation in the Contralesional Hemisphere?

Dev Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

Université d'Angers, Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), EA, 7315, 49000, Angers, France.

Although neonatal arterial ischemic Stroke is now well-studied, its complex consequences on long-term cortical brain development has not yet been solved. In order to understand the brain development after focal early brain lesion, brain morphometry needs to be evaluated using structural parameters. In this work, our aim was to study and analyse the changes in morphometry of ipsi- and contralesional hemispheres in seven-year-old children following neonatal stroke. Read More

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http://dx.doi.org/10.1002/dneu.22679DOI Listing

Evaluation of the foal survival score in a Danish-Swedish population of neonatal foals upon hospital admission.

J Vet Intern Med 2019 Apr 19. Epub 2019 Apr 19.

Medicine and Surgery, Department of Veterinary Clinical Sciences, University of Copenhagen, Taastrup, Denmark.

Background: It is highly desirable to assess the probability of survival in sick neonatal foals upon admission. The foal survival score (FSS) is a published scoring system used to estimate the probability of survival in hospitalized neonatal foals <4 days old.

Hypothesis/objectives: To evaluate the ability of the FSS to predict survival in older foals from a geographically different area compared to the original study. Read More

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http://dx.doi.org/10.1111/jvim.15487DOI Listing

N-myc downstream-regulated gene 2 controls astrocyte morphology via Rho-GTPase signaling.

J Cell Physiol 2019 Apr 19. Epub 2019 Apr 19.

Anesthesia and Operation Center, The First Medical Center to Chinese PLA General Hospital, Beijing, China.

Astrocyte undergoes morphology changes that are closely associated with the signaling communications at synapses. N-myc downstream-regulated gene 2 (NDRG2) is specifically expressed in astrocytes and is associated with several important astrocyte functions, but its potential role(s) relating to astrocyte morphological changes remain unknown. Here, primary astrocytes were prepared from neonatal Ndrg2 and Ndrg2 pups, and the drug Y27632 was used to induce stellation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28689
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http://dx.doi.org/10.1002/jcp.28689DOI Listing
April 2019
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Increased nurse workload is associated with bloodstream infections in very low birth weight infants.

Sci Rep 2019 Apr 19;9(1):6331. Epub 2019 Apr 19.

Division of Neonatology, Pediatric Intensive Care & Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Neonatal sepsis is a major cause of morbidity and mortality in very low birth weight infants (VLBWI). Nurse workload considerably affects infection rates in intensive care units. However, data concerning the impact of staff workload on bloodstream infections (BSI) in VLBWI are scarce. Read More

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http://dx.doi.org/10.1038/s41598-019-42685-xDOI Listing

Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants.

Sci Rep 2019 Apr 19;9(1):6322. Epub 2019 Apr 19.

Department of Pediatrics, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, United States.

Neonatal molecular biomarkers of neurobehavioral responses (measures of brain-behavior relationships), when combined with neurobehavioral performance measures, could lead to better predictions of long-term developmental outcomes. To this end, we examined whether variability in buccal cell DNA methylation (DNAm) associated with neurobehavioral profiles in a cohort of infants born less than 30 weeks postmenstrual age (PMA) and participating in the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study (N = 536). We tested whether epigenetic age, age acceleration, or DNAm levels at individual loci differed between infants based on their NICU Network Neurobehavioral Scale (NNNS) profile classifications. Read More

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http://www.nature.com/articles/s41598-019-42654-4
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http://dx.doi.org/10.1038/s41598-019-42654-4DOI Listing
April 2019
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Identification of High-Yield Targets for Antimicrobial Stewardship Program Efforts Within a Nonfreestanding Children's Hospital.

Hosp Pediatr 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Division of Infectious Diseases.

Objectives: Identify diagnoses with the highest likelihood of prompting antimicrobial stewardship program (ASP) recommendations and lowest probability of recommendation acceptance, investigate the impact of provider years in practice on recommendation receipt and acceptance, and simultaneously assess the influence of patient and provider-level variables associated with recommendations within a nonfreestanding children's hospital.

Methods: Retrospective cohort study of antibiotic courses reviewed by the ASP staff from December 1, 2014 to November 30, 2016. Poisson regression was used to detect associations between diagnoses, provider years in practice, and the probability of recommendation receipt and acceptance. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0254DOI Listing

A Common Receptor Found for Echoviruses.

Trends Microbiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Biological and Environmental Science, Nanoscience Center, University of Jyväskylä, PO, Box 35, FI-40014 Jyväskylä, Finland. Electronic address:

It has remained a puzzle why infants, during the first weeks of life, are especially prone to enterovirus infections. New work (Proc. Natl. Read More

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http://dx.doi.org/10.1016/j.tim.2019.03.010DOI Listing
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