8,395 results match your criteria Neonatal Meningitis


Group B streptococcus prevalence, serotype distribution and colonization dynamics in Western Australian pregnant women.

J Med Microbiol 2019 Apr 23. Epub 2019 Apr 23.

1 The School of Medicine, Division of Obstetrics and Gynaecology, The University of Western Australia, Australia.

Purpose: Streptococcus agalactiae, or group B streptococcus (GBS), is a leading neonatal pathogen that causes sepsis, meningitis and pneumonia. Globally, strategies have been implemented to address vertical transmission, and in Western Australia (WA), culture-based screening at 35-37 weeks' gestation is part of routine care and guides antibiotic administration. Previous Australian studies have focused on other regions or included low sample-size representatives; we aimed to describe antenatal GBS colonization in WA. Read More

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https://www.microbiologyresearch.org/content/journal/jmm/10.
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http://dx.doi.org/10.1099/jmm.0.000980DOI Listing
April 2019
1 Read

Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017.

Emerg Infect Dis 2019 May;25(5):972-975

We characterized a case of neonatal conjunctivitis in New York, USA, caused by Neisseria meningitidis by using whole-genome sequencing. The case was a rare occurrence, and the isolate obtained belonged to an emerging clade (N. meningitidis US nongroupable urethritis) associated with an increase in cases of urethritis since 2015. Read More

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http://dx.doi.org/10.3201/eid2505.181631DOI Listing

Population-based study of early-onset neonatal sepsis in Canada.

Paediatr Child Health 2019 May 24;24(2):e66-e73. Epub 2018 Apr 24.

Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario.

Objective: To determine the incidence, types of organisms and resistance patterns involved in early-onset neonatal sepsis in Canada.

Study Design: Early-onset neonatal sepsis cases were identified through the Canadian Paediatric Surveillance Program. Neonates were excluded if they were asymptomatic or if intracranial procedures preceded a positive cerebrospinal fluid culture. Read More

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https://academic.oup.com/pch/article/24/2/e66/4983126
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http://dx.doi.org/10.1093/pch/pxy018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462127PMC
May 2019
1 Read

Prevalence of group B streptococcus among pregnant women and newborns at Hawassa University comprehensive specialized hospital, Hawassa, Ethiopia.

BMC Infect Dis 2019 Apr 16;19(1):325. Epub 2019 Apr 16.

Department of Pediatrics, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Group B streptococcus (GBS) is reported as the leading cause of neonatal sepsis and meningitis. Newborns from GBS colonized pregnant women are at high risk of infection.

Method: A Hospital based cross-sectional study was conducted at Hawassa University Comprehensive Specialized Hospital from November 05, 2014 to March 25, 2015. Read More

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http://dx.doi.org/10.1186/s12879-019-3859-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469063PMC

Epidemiology of Meningitis in Canadian Neonatal Intensive Care Units.

Pediatr Infect Dis J 2019 May;38(5):476-480

Maternal-Infant Care (MiCare) Research Centre, Mount Sinai Hospital.

Background: Meningitis is a serious disease that occurs more commonly in the neonatal period than in any other age group. Recent data from large national cohorts are needed to determine if the epidemiology of neonatal meningitis (NM) has changed.

Aim: To assess the rates, causative organisms, risk factors, temporal trends and short-term outcomes of NM in Canadian Neonatal Intensive Care Units (NICUs). Read More

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http://Insights.ovid.com/crossref?an=00006454-201905000-0000
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http://dx.doi.org/10.1097/INF.0000000000002247DOI Listing
May 2019
2 Reads

Surveillance for incidence and etiology of early-onset neonatal sepsis in Soweto, South Africa.

PLoS One 2019 10;14(4):e0214077. Epub 2019 Apr 10.

Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Globally, over 400,000 neonatal deaths in 2015 were attributed to sepsis, however, the incidence and etiologies of these infections are largely unknown in low-middle income countries. We aimed to determine incidence and etiology of community-acquired early-onset (<72 hours age) sepsis (EOS) using culture and molecular diagnostics.

Methods: This was a prospective observational study, in which we conducted a surveillance for pathogens using a combination of blood culture and a polymerase chain reaction (PCR)-based test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214077PLOS
April 2019
6 Reads

Characterization of Erythromycin and Tetracycline Resistance Genes of Streptococcus gallolyticus Subspecies pasteurianus Strains Isolated from Patients with Septicemia and Bacteremia in Thailand.

Clin Lab 2019 Apr;65(4)

Background: Streptococcus gallolyticus subspecies (subsp.) pasteurianus, previously known as Streptococcus bovis biotype II/2, has been described as a causative agent of endocarditis, neonatal sepsis, meningitis, bacteremia, and colorectal carcinoma in humans. The aim of this study was to characterize the erythromycin and tetracycline resistance genes of S. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180902DOI Listing
April 2019
4 Reads

Value of MRI enhanced FLAIR sequence examination combined with CSF TNF-α detection in the early diagnosis of neonatal purulent meningitis.

Exp Ther Med 2019 Apr 22;17(4):3124-3128. Epub 2019 Feb 22.

Department of Neonatology, Linyi Women and Children's Hospital, Linyi, Shandong 276014, P.R. China.

This study aimed to investigate the value of MRI enhanced fluid-attenuated inversion recovery (FLAIR) combined with TNF-α in cerebrospinal fluid in the diagnosis of neonatal purulent meningitis. Fifty neonates with purulent meningitis were randomly selected in the purulency group, 50 patients with viral meningitis (VM) in the virus group and 50 neonates without purulent meningitis in the no meningitis group. All neonates were selected from April 2015 to May 2018 in Women and Children's Hospital (Linyi, China). Read More

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http://dx.doi.org/10.3892/etm.2019.7305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434275PMC
April 2019
1 Read

Peripheral blood neutrophil-to-lymphocyte ratio in preterm infants with intraventricular hemorrhage.

Clin Neurol Neurosurg 2019 May 16;180:52-56. Epub 2019 Mar 16.

Division of Pediatric Neurosurgery, Joe DiMaggio Children's Hospital, 1150 N 35th Ave., Hollywood, FL, 33021, USA. Electronic address:

Objectives: Intraventricular hemorrhage (IVH) remains a major complication of prematurity, affecting 20-25% of premature infants of very low birth weight. Preterm infants with IVH are at risk for developing significant complications, including posthemorrhagic hydrocephalus and seizures. Multiple studies have reported an association between the neutrophil-to-lymphocyte ratio (NLR) in peripheral blood and outcomes after acute intracranial hemorrhage in adults. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.012DOI Listing
May 2019
2 Reads

Effect of NT-3 on infection-induced memory impairment of neonatal rats.

Eur Rev Med Pharmacol Sci 2019 Mar;23(5):2182-2187

Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University of Medical College, Jiangyin, Jiangsu, China.

Objective: To explore the effect of neurotrophin-3 (NT-3) messenger ribonucleic acid (mRNA) in the hippocampus on infection-induced memory impairment of neonatal rats.

Materials And Methods: 80 female Sprague-Dawley (SD) rats in the neonatal stage were selected to establish memory impairment model by bacterial meningitis infection. Rats were randomly divided into experimental group (n=40) and control group (n=40). Read More

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http://dx.doi.org/10.26355/eurrev_201903_17264DOI Listing
March 2019
1 Read

Subspecies Typing of Based on Ribosomal Subunit Protein Mass Variation by MALDI-TOF MS.

Front Microbiol 2019 11;10:471. Epub 2019 Mar 11.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute (Swiss TPH) Basel, Basel, Switzerland.

A ribosomal subunit protein (rsp)-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) method was developed for fast subspecies-level typing of (Group B , GBS), a major cause of neonatal sepsis and meningitis. A total of 796 GBS whole genome sequences, covering the genetic diversity of the global GBS population, were used to predict molecular mass variability of 28 rsp and to identify unique rsp mass combinations, termed "rsp-profiles". The established GBS typing scheme was validated by MALDI-TOF MS analysis of GBS isolates at two independent research sites in Europe and South East Asia. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421976PMC
March 2019
1 Read

Spinal Intradural E. Coli Abscess Masquerading as a Neoplasm in a Pediatric Patient with History of Neonatal E. Coli Meningitis: a case report and literature review.

World Neurosurg 2019 Mar 20. Epub 2019 Mar 20.

Department of Neurological Surgery, Loyola University Medical Center, Maywood IL USA. Electronic address:

Central nervous system abscesses can frequently be seen in the immunocompromised population and most commonly consist of intracranial collections in the adult patient. Spinal intradural abscesses are less commonly encountered, and there are even fewer numbers in the pediatric population with a concordant absence of documentation in the published literature. In this case report we describe the presentation of a two year-old male with a history of perinatal Escherichia coli (E. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.243DOI Listing
March 2019
1 Read

Impact of maternal smoking on early childhood health: a retrospective cohort linked dataset analysis of 697 003 children born in Scotland 1997-2009.

BMJ Open 2019 Mar 20;9(3):e023213. Epub 2019 Mar 20.

Scottish Cot Death Trust, 5th Floor, West Glasgow Ambulatory Care Hospital, University of Glasgow, Glasgow, UK.

Objective: Smoking during pregnancy is associated with adverse health impacts on mother and child. We used a large linked Scottish dataset to produce contemporary estimates of the impact on child health, particularly hospitalisation.

Design: Retrospective cohort study linking birth, death, maternity, infant health, child health surveillance and admission records. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023213DOI Listing
March 2019
2 Reads

Invasive Pneumococcal Disease in Neonates Prior to Pneumococcal Conjugate Vaccine Use in South Africa: 2003-2008.

Pediatr Infect Dis J 2019 Apr;38(4):424-430

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg.

Background: Neonatal invasive pneumococcal disease (IPD) in developing countries is poorly described. We provide a baseline description of neonatal IPD in South Africa, before implementation of the 7-valent pneumococcal conjugate vaccine (PCV7) in 2009.

Methods: Data from children (age ≤ 2 years) with IPD (pneumococcus identified from a normally sterile specimen) from January 2003 to December 2008 were extracted from a national laboratory-based surveillance database. Read More

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http://dx.doi.org/10.1097/INF.0000000000002096DOI Listing
April 2019
6 Reads

Central Line-Associated Blood Stream Infections and Non-Central Line-Associated Blood Stream Infections Surveillance in Canadian Tertiary Care Neonatal Intensive Care Units.

J Pediatr 2019 Mar 7. Epub 2019 Mar 7.

Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.

Objective: To determine if the reported reduction in hospital-acquired infections is due to reduced central line-associated blood stream infections (CLABSI) or non-CLABSIs.

Study Design: A retrospective cohort study design was used to describe the change in organism pattern and incidence of hospital-acquired infections (CLABSIs and non-CLABSIs) in neonates <33 weeks of gestation admitted to tertiary neonatal intensive care units in the Canadian Neonatal Network between January 1, 2010, and December 31, 2016. Hospital-acquired infection was diagnosed when a pathogenic organism was isolated from blood or cerebrospinal fluid in a neonate with suspected sepsis. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.011DOI Listing
March 2019
1 Read

Treatment of Hypothalamic Obesity with Dextroamphetamine: A Case Series.

Obes Facts 2019 7;12(1):91-102. Epub 2019 Mar 7.

Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany.

Background: A limited number of published case reports suggest a positive effect of dextroamphetamine, an adrenergic agonist affecting both the central nervous system (CNS) and peripheral nervous system, on physical activity and weight in patients with hypothalamic obesity (intractable obesity following CNS insult). Here, we present our clinical experience with dextroamphetamine treatment for hypothalamic obesity.

Methods: The clinical course of all patients started on dextroamphetamine treatment for severe hypothalamic obesity at our institution between 2010 and 2013 is reported. Read More

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http://dx.doi.org/10.1159/000495851DOI Listing
March 2019
2 Reads

Early Onset Neonatal E.Coli Sepsis

Ir Med J 2019 Feb 14;112(2):868. Epub 2019 Feb 14.

Department of Neonatology, Rotunda Hospital

This was a retrospective case-control study over 14 years comparing characteristics of neonates who developed E.coli bacteraemia with matched infant controls whose mothers were colonised with E.coli on high vaginal swab but who did not develop bacteraemia. Read More

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February 2019
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Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen K1.

Infect Immun 2019 Mar 23;87(5). Epub 2019 Apr 23.

School of Pharmacy, University College London, London, United Kingdom

Gastrointestinal (GI) colonization of 2-day-old (P2) rat pups with K1 results in translocation of the colonizing bacteria across the small intestine, bacteremia, and invasion of the meninges, with animals frequently succumbing to lethal infection. Infection, but not colonization, is strongly age dependent; pups become progressively less susceptible to infection over the P2-to-P9 period. Colonization leads to strong downregulation of the gene encoding trefoil factor 2 (Tff2), preventing maturation of the protective mucus barrier in the small intestine. Read More

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http://dx.doi.org/10.1128/IAI.00878-18DOI Listing
March 2019
2 Reads

Virulence factors, prevalence and potential transmission of extraintestinal pathogenic isolated from different sources: recent reports.

Gut Pathog 2019 21;11:10. Epub 2019 Feb 21.

1Department of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, Chalubinskiego 4, 50-368 Wroclaw, Poland.

Extraintestinal pathogenic . (ExPEC) are facultative pathogens that are part of the normal human intestinal flora. The ExPEC group includes uropathogenic (UPEC), neonatal meningitis (NMEC), sepsis-associated (SEPEC), and avian pathogenic (APEC). Read More

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http://dx.doi.org/10.1186/s13099-019-0290-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383261PMC
February 2019
3 Reads

Active contact tracing beyond the household in multidrug resistant tuberculosis in Vietnam: a cohort study.

BMC Public Health 2019 Feb 28;19(1):241. Epub 2019 Feb 28.

Oxford University Clinical Research Unit, Hanoi, Vietnam.

Background: Currently in Vietnam contact tracing for multidrug-resistant tuberculosis (MDR-TB) entails passive case finding among symptomatic household contacts who present themselves for diagnosis. Close contacts of MDR-TB cases are therefore not identified adequately. We assessed the added value of active contact tracing within and beyond households using social network questionnaires to identify close contacts of MDR-TB patients in Vietnam. Read More

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http://dx.doi.org/10.1186/s12889-019-6573-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394002PMC
February 2019

Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study.

Front Pediatr 2019 13;7:31. Epub 2019 Feb 13.

Department of Pediatric Infectious Diseases, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Neonatal bacterial meningitis is a severe infectious disease with a high risk of neurodevelopmental sequelae. The causative pathogens may be related to specific clinical features of the disease. Therefore, this study aimed at determining the pathogen-specific and clinical features of bacterial meningitis in full-term neonates. Read More

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http://dx.doi.org/10.3389/fped.2019.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381005PMC
February 2019
6 Reads

The neonatal Fc receptor is a pan-echovirus receptor.

Proc Natl Acad Sci U S A 2019 02 11;116(9):3758-3763. Epub 2019 Feb 11.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224;

Echoviruses are amongst the most common causative agents of aseptic meningitis worldwide and are particularly devastating in the neonatal population, where they are associated with severe hepatitis, neurological disease, including meningitis and encephalitis, and even death. Here, we identify the neonatal Fc receptor (FcRn) as a pan-echovirus receptor. We show that loss of expression of FcRn or its binding partner beta 2 microglobulin (β2M) renders cells resistant to infection by a panel of echoviruses at the stage of virus attachment, and that a blocking antibody to β2M inhibits echovirus infection in cell lines and in primary human intestinal epithelial cells. Read More

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http://dx.doi.org/10.1073/pnas.1817341116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397586PMC
February 2019
2 Reads

A retrospective study (2001-2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit.

Ir J Med Sci 2019 Feb 25. Epub 2019 Feb 25.

Clinical Innovation Unit, Rotunda Hospital, Dublin 1, Ireland.

Background: Staphylococcus aureus bacteraemia (SAB) in NICU patients can cause significant morbidity and mortality.

Aims: To review early and late neonatal SAB with regard to risk factors, treatment, acute complications and long-term outcomes.

Methods: A retrospective study of laboratory confirmed SAB over a 16-year period (November 2001-January 2017) in a tertiary neonatal unit in Ireland. Read More

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http://link.springer.com/10.1007/s11845-019-01992-y
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http://dx.doi.org/10.1007/s11845-019-01992-yDOI Listing
February 2019
3 Reads

Absence of Global Stress Regulation in Escherichia coli Promotes Pathoadaptation and Novel c-di-GMP-dependent Metabolic Capability.

Sci Rep 2019 Feb 22;9(1):2600. Epub 2019 Feb 22.

The Laboratory for Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umea, Sweden.

Pathoadaptive mutations linked to c-di-GMP signalling were investigated in neonatal meningitis-causing Escherichia coli (NMEC). The results indicated that NMEC strains deficient in RpoS (the global stress regulator) maintained remarkably low levels of c-di-GMP, a major bacterial sessility-motility switch. Deletion of ycgG2, shown here to encode a YcgG allozyme with c-di-GMP phosphodiesterase activity, and the restoration of RpoS led to a decrease in S-fimbriae, robustly produced in artificial urine, hinting that the urinary tract could serve as a habitat for NMEC. Read More

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http://www.nature.com/articles/s41598-019-39580-w
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http://dx.doi.org/10.1038/s41598-019-39580-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385356PMC
February 2019
10 Reads

Infections in Neonatal Intensive Care Units (NICUs).

Int J Environ Res Public Health 2019 02 20;16(4). Epub 2019 Feb 20.

Department of Health Sciences, University of Genoa, Italy Via Pastore, 1-16132 Genoa, Italy.

belongs to the family Enterobacteriaceae, which is commonly found in water, soil, animals, insects, plants. Although displays relatively low virulence, it causes nosocomial infections and outbreaks in severely immunocompromised or critically ill patients, particularly in settings such as intensive care units (ICUs), especially neonatal units (NICUs). This microorganism gives rise to a wide range of clinical manifestations in newborns: from asymptomatic colonization to keratitis, conjunctivitis, urinary tract infections, pneumonia, surgical wound infections, sepsis, bloodstream infection and meningitis. Read More

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http://dx.doi.org/10.3390/ijerph16040610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406414PMC
February 2019
1 Read

Treatment of Elizabethkingia meningoseptica Neonatal Meningitis with Combination Systemic and Intraventricular Therapy.

Indian J Pediatr 2019 Apr 21;86(4):379-381. Epub 2019 Feb 21.

Department of Pediatrics, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Four Bungalows, Andheri West, Mumbai, 400053, India.

Elizabethkingia meningoseptica, a gram negative bacillus ubiquitous in the hospital environment, is known to infrequently cause serious neonatal infections, particularly meningitis which is associated with high mortality and neuromorbidity in survivors. The authors describe a healthy term newborn with no apparent risk factors who developed Elizabethkingia meningoseptica sepsis and meningitis on day 6 of life. Diagnosis could be established only after a week of the illness by which time the baby developed refractory status epilepticus, ventriculitis and hydrocephalus. Read More

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http://dx.doi.org/10.1007/s12098-019-02875-xDOI Listing
April 2019
1 Read

Mother-to-child transmission and gestational syphilis: Spatial-temporal epidemiology and demographics in a Brazilian region.

PLoS Negl Trop Dis 2019 02 21;13(2):e0007122. Epub 2019 Feb 21.

Faculdade de Ciências da Saúde, Biomedicina, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil.

Syphilis is a Sexually Transmitted Infection (IST) with significant importance to public health, due to its impact during pregnancy (Gestational Syphilis-GS); especially because syphilis can affect fetus and neonates' development (mother-to-child transmission-MTCT of syphilis), by increasing susceptibility to abortion, premature birth, skeletal malformations, meningitis and pneumonia. Measures to control and eliminate MTCT of syphilis have failed on the last few years in Brazil and this research aimed to identify the seasonality of notified cases of syphilis in a region of São Paulo state. The studied region, Pontal do Paranapanema, comprises 32 cities located in the West of São Paulo state, in Brazil. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383870PMC
February 2019
2 Reads

Prevalence and capsular type distribution of Streptococcus agalactiae isolated from pregnant women in Namibia and South Africa.

BMC Infect Dis 2019 Feb 20;19(1):179. Epub 2019 Feb 20.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Private Bag X1314, Alice, Eastern Cape Province, 5700, South Africa.

Background: Streptococcus agalactiae or Group B Streptococcus (GBS) is the leading cause of neonatal morbidity and mortality resulting in septicaemia, bacteraemia and meningitis. Long term problems in children range from loss of hearing to mental retardation. While Intrapartum Antibiotic Prophylaxis (IAP) has reduced the incidence of S. Read More

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http://dx.doi.org/10.1186/s12879-019-3809-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383256PMC
February 2019
4 Reads

Severe cryopyrin-associated periodic syndrome first characterized by early childhood-onset sensorineural hearing loss - Case report and literature review.

Int J Pediatr Otorhinolaryngol 2019 May 28;120:68-72. Epub 2019 Jan 28.

Division of Pediatric Rheumatology, Department of Pediatrics, IWK Health Centre, 5850/5980 University Ave, PO Box 9700, Halifax, NS, B3K 6R8, Canada. Electronic address:

Infant-onset bilateral sensorineural hearing loss is a key presenting symptom of the autoinflammatory cryopyrin-associated periodic syndrome. Other symptoms include periodic fever, cold-induced urticaria-like rash, chronic aseptic meningitis, polyarticular arthralgias, and renal AA amyloidosis. Early recognition and treatment with interleukin-1 blockade are critical for preventing disabling or fatal complications. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.037DOI Listing
May 2019
2 Reads

Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.

BMC Res Notes 2019 Feb 14;12(1):85. Epub 2019 Feb 14.

Section of Paediatrics, Department of Medicine, Imperial College London, London, UK.

Objective: Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis worldwide. Intrapartum antibiotics given to women carrying GBS are an effective means of reducing disease in the first week of life. Rapid and reliable tests are needed to accurately identify GBS from these women for timely intrapartum antibiotic administration to prevent neonatal disease. Read More

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http://dx.doi.org/10.1186/s13104-019-4119-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376729PMC
February 2019
2 Reads

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. Read More

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http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374915PMC
February 2019
3 Reads

Early-Onset Neonatal Meningitis Caused by an Unusual Pathogen-.

Case Rep Pediatr 2019 9;2019:4740504. Epub 2019 Jan 9.

Professor and Head, Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Introduction: are part of the normal flora of the human respiratory tract and are known to have low pathogenic potential. The organism is rarely reported in the literature as the causative agent of meningitis. We report the first case of early-onset neonatal meningitis associated with from Nepal. Read More

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http://dx.doi.org/10.1155/2019/4740504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343129PMC
January 2019
3 Reads

Role of Two-Component System Response Regulator in the Antimicrobial Resistance, Virulence, Biofilm Formation, and Stress Response of Group B Streptococcus.

Front Microbiol 2019 23;10:10. Epub 2019 Jan 23.

Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong.

Group B Streptococcus (GBS; ) is a leading cause of sepsis in neonates and pregnant mothers worldwide. Whereas the hyper-virulent serogroup III clonal cluster 17 has been associated with neonatal disease and meningitis, serogroup III ST283 was recently implicated in invasive disease among non-pregnant adults in Asia. Here, through comparative genome analyses of invasive and non-invasive ST283 strains, we identified a truncated DNA-binding regulator of a two-component system in a non-invasive strain that was homologous to , encoding the response regulator, which was conserved among GBS strains. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00010
Publisher Site
http://dx.doi.org/10.3389/fmicb.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351488PMC
January 2019
13 Reads
3.941 Impact Factor

Comparing Single vs. Combined Cerebrospinal Fluid Parameters for Diagnosing Full-Term Neonatal Bacterial Meningitis.

Front Neurol 2019 23;10:12. Epub 2019 Jan 23.

Pediatric Infectious Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

To identify and compare the cerebrospinal fluid (CSF) parameters that predict the presence of neonatal bacterial meningitis using optimal cutoff values, and to derive and compare predictive profiles based on a combination of individual parameters for the same purpose. The retrospective component of the Shanghai Neonate Meningitis Cohort included all term neonates who underwent lumbar puncture between 2000 and 2017. Those with severe neurological diseases, histories of ventricular drainage, or traumatic lumbar punctures were excluded. Read More

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http://dx.doi.org/10.3389/fneur.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351467PMC
January 2019
2 Reads

MicroRNA-135a participates in the development of astrocytes derived from bacterial meningitis by downregulating HIF-1α.

Am J Physiol Cell Physiol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Accumulating evidence has highlighting the potential of microRNAs (miRs) as biomarkers in various human diseases. However, the roles of miRs in bacterial meningitis (BM), a severe infectious condition, still remain unclear. Thus, the present study aimed to investigate the effects of miR-135a on proliferation and apoptosis of astrocytes in BM. Read More

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http://dx.doi.org/10.1152/ajpcell.00440.2018DOI Listing
February 2019
8 Reads

The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle 98195, WA, USA; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle 98101, WA, USA; Department of Pediatrics, University of Washington School of Medicine, Seattle 98195, WA, USA. Electronic address:

Group B streptococcus (GBS) is a β-hemolytic gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.01.035DOI Listing
January 2019
9 Reads

Escherichia coli-infected cephalohematoma in an infant.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

We report a case of Escherichia coli infection of a cephalohematoma in an infant delivered by vacuum extraction. After excluding potential complications, the patient was treated with intravenous ceftriaxone while hospitalized followed by oral cephalexin after discharge. Infection is a rare but serious complication of cephalohematomas in the newborn period. Read More

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November 2018
9 Reads

Early onset sepsis calculator-based management of newborns exposed to maternal intrapartum fever: a cost benefit analysis.

J Perinatol 2019 Apr 28;39(4):571-580. Epub 2019 Jan 28.

University of Southern California Leonard D. Schaeffer Center for Health Policy & Economics, Los Angeles, CA, USA.

Objective: To determine potential net monetary benefit of an early onset sepsis calculator-based approach for management of neonates exposed to maternal intrapartum fever, compared to existing guidelines.

Study Design: We performed a cost-benefit analysis comparing two management approaches for newborns >34 weeks gestational age exposed to maternal intrapartum fever. Probabilities of sepsis and meningitis, consequences of infection and antibiotic use, direct medical costs, and indirect costs for long-term disability and mortality were considered. Read More

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http://dx.doi.org/10.1038/s41372-019-0316-yDOI Listing
April 2019
2 Reads

Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece.

Infect Dis Rep 2018 Nov 5;10(3):7744. Epub 2018 Dec 5.

Department or Pediatrics, University of Crete, School of Medicine.

Group B streptococcus (GBS) remains a leading cause of neonatal disease. However, GBS rates and prevention strategies vary considerably worldwide. Herein, we investigated the burden and epidemiological trends of neonatal GBS infections in our area (Greece) over the last two decades. Read More

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http://dx.doi.org/10.4081/idr.2018.7744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315311PMC
November 2018
3 Reads

Genome sequencing of strains of the most prevalent clonal group of O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.

BMC Microbiol 2019 Jan 17;19(1):17. Epub 2019 Jan 17.

IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

Background: To describe the temporal dynamics, molecular characterization, clinical and ex vivo virulence of emerging O1:K1 neonatal meningitis Escherichia coli (NMEC) strains of Sequence Type complex (STc) 95 in France. The national reference center collected NMEC strains and performed whole genome sequencing (WGS) of O1:K1 STc95 NMEC strains for phylogenetic and virulence genes content analysis. Data on the clinical and biological features of patients were also collected. Read More

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https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12866-018-1376-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337857PMC
January 2019
13 Reads

A retrospective review of Listeria monocytogenes infection at Tygerberg Children's Hospital, Cape Town, South Africa, from 2006 to 2016: Is empirical ampicillin still indicated after the first month of life?

S Afr Med J 2018 Oct 26;108(11):937-943. Epub 2018 Oct 26.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Ampicillin to treat Listeria monocytogenes (LM) infection is empirically added to the treatment of infants (<3 months) with suspected sepsis or meningitis.

Objectives: In view of limited LM cases, the paucity of South African (SA) data and an ampicillin shortage, our objective was to describe the occurrence of LM infections at Tygerberg Hospital (TBH), Cape Town, with the aim of rationalising the paediatric antibiotic policy.

Methods: An 11-year (2006 - 2016) retrospective descriptive study of children (<13 years) from TBH and referral hospitals with a positive blood or cerebrospinal fluid (CSF) culture for LM was conducted. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.13212DOI Listing
October 2018
4 Reads

Neonatal meningoencephalitis caused by human adenovirus species F infection.

Pediatr Int 2019 Jan 10;61(1):99-101. Epub 2019 Jan 10.

Department of Pediatrics, Sakura Medical Center, Toho University, Chiba, Japan.

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http://doi.wiley.com/10.1111/ped.13722
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http://dx.doi.org/10.1111/ped.13722DOI Listing
January 2019
5 Reads

Rapid and Simple Universal Genotyping Method Based on Multiple-Locus Variable-Number Tandem-Repeat Analysis Using Single-Tube Multiplex PCR and Standard Gel Electrophoresis.

Appl Environ Microbiol 2019 Mar 6;85(6). Epub 2019 Mar 6.

Service de Microbiologie, Centre National de Référence Associé Escherichia coli, Hôpital Robert-Debré, AP-HP, Paris, France.

We developed a multiplex PCR method based on multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) that was designed for the rapid typing of and isolates. The method amplifies seven VNTRs and does not require a sequencing capillary or fluorescent dyes. The amplification products are simply loaded on a standard agarose gel for electrophoresis, and the banding patterns are analyzed visually. Read More

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http://dx.doi.org/10.1128/AEM.02812-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414366PMC
March 2019
6 Reads
3.668 Impact Factor

Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016.

BMC Infect Dis 2018 Dec 29;18(1):709. Epub 2018 Dec 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa and the National Health Laboratory Service, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. Laboratory and syndromic surveillance during December 2015 and January 2016 noted an unusually high number of paediatric aseptic meningitis cases at a hospital in Mossel Bay, Western Cape Province, South Africa. HEV was detected in clinical samples, prompting an outbreak investigation. Read More

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http://dx.doi.org/10.1186/s12879-018-3641-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311073PMC
December 2018
2 Reads

Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin monotherapy in Escherichia coli meningitis in infants: a multicentre propensity score-matched observational study.

Clin Microbiol Infect 2018 Dec 27. Epub 2018 Dec 27.

Neonatal Intensive Care Unit, Créteil, France; Centre de Recherche Clinique, Centre Hospitalier Intercommunal de Créteil, Créteil, France; Université Paris Est Créteil, Créteil, France.

Objectives: Escherichiacoli is the second cause of bacterial meningitis in neonates. Despite the use for 35 years of third-generation cephalosporins (3GCs), high morbidity and mortality rates with E. coli meningitis continue to occur. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.12.026DOI Listing
December 2018
1 Read

Emerging Infection with in Neonate. A Case Report.

J Crit Care Med (Targu Mures) 2018 Jul 1;4(3):96-100. Epub 2018 Jul 1.

"Dunarea de Jos" University, Medicine and Pharmacy Research Centre, Galati Romania.

Background: are Gram-negative rod bacteria which are commonly found in the environment. The bacteria have also been associated with nosocomial infections, having been isolated on contaminated medical equipment, especially in neonatal wards.

Case Report: Here, we present the case of a premature female infant born at 33 weeks' gestational age, with neonatal meningitis. Read More

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http://content.sciendo.com/view/journals/jccm/4/3/article-p9
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http://dx.doi.org/10.2478/jccm-2018-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294984PMC
July 2018
14 Reads

Approach to Neonates and Young Infants with Fever without a Source Who Are at Risk for Severe Bacterial Infection.

Mediators Inflamm 2018 26;2018:4869329. Epub 2018 Nov 26.

Pediatrics, Università degli Studi di Milano, Milan, Italy.

Introduction: Among neonates and infants <3 months of age with fever without a source (FWS), 5% to 15% of cases are patients with fever caused by a serious bacterial infection (SBI). To favour the differentiation between low- and high-risk infants, several algorithms based on analytical and clinical parameters have been developed. The aim of this review is to describe the management of young infants with FWS and to discuss the impact of recent knowledge regarding FWS management on clinical practice. Read More

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http://dx.doi.org/10.1155/2018/4869329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287153PMC
April 2019
2 Reads

Central Diabetes Insipidus in an Infant with Pneumococcal Meningitis.

Fetal Pediatr Pathol 2019 Feb 22;38(1):80-84. Epub 2018 Dec 22.

a Neonatology , University of Health Sciences, Dr Sami Ulus Maternity and Children Health and Research Application Center , Ankara , Türkiye.

Background: Central diabetes is an infrequent complication reported in the neonatal period.

Case Report: CDI as a complication of Streptococcus pneumoniae (S. pneumoniae) sepsis and meningitis in a 9-day-old boy is presented. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2018.1
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http://dx.doi.org/10.1080/15513815.2018.1547335DOI Listing
February 2019
12 Reads

Murine myeloid-derived suppressor cells are a source of elevated levels of interleukin-27 in early life and compromise control of bacterial infection.

Immunol Cell Biol 2018 Dec 21. Epub 2018 Dec 21.

Department of Microbiology, Immunology, & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.

Microbial infections early in life remain a major cause of infant mortality worldwide. This is consistent with immune deficiencies in this population. Interleukin (IL)-27 is suppressive toward a variety of immune cell types, and we have shown that the production of IL-27 is elevated in humans and mice early in life. Read More

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http://dx.doi.org/10.1111/imcb.12224DOI Listing
December 2018
3 Reads

New molecular tools for meningitis diagnostics in Ethiopia - a necessary step towards improving antimicrobial prescription.

BMC Infect Dis 2018 Dec 20;18(1):684. Epub 2018 Dec 20.

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Meningitis remains a top cause of premature death and loss of disability-adjusted life years in low-income countries. In resource-limited settings, proper laboratory diagnostics are often scarce and knowledge about national and local epidemiology is limited. Misdiagnosis, incorrect treatment and overuse of antibiotics are potential consequences, especially for viral meningitis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3589-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302510PMC
December 2018
13 Reads
2.613 Impact Factor