8,349 results match your criteria Neonatal Meningitis


Evaluation of matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) for the Identification of Group B Streptococcus.

BMC Res Notes 2019 Feb 14;12(1):85. Epub 2019 Feb 14.

Section of Paediatrics, Department of Medicine, Imperial College London, London, UK.

Objective: Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis worldwide. Intrapartum antibiotics given to women carrying GBS are an effective means of reducing disease in the first week of life. Rapid and reliable tests are needed to accurately identify GBS from these women for timely intrapartum antibiotic administration to prevent neonatal disease. Read More

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http://dx.doi.org/10.1186/s13104-019-4119-1DOI Listing
February 2019

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. Read More

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http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
February 2019

Early-Onset Neonatal Meningitis Caused by an Unusual Pathogen-.

Case Rep Pediatr 2019 9;2019:4740504. Epub 2019 Jan 9.

Professor and Head, Department of Microbiology, BP Koirala Institute of Health Sciences, Dharan, Nepal.

Introduction: are part of the normal flora of the human respiratory tract and are known to have low pathogenic potential. The organism is rarely reported in the literature as the causative agent of meningitis. We report the first case of early-onset neonatal meningitis associated with from Nepal. Read More

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http://dx.doi.org/10.1155/2019/4740504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343129PMC
January 2019
1 Read

Role of Two-Component System Response Regulator in the Antimicrobial Resistance, Virulence, Biofilm Formation, and Stress Response of Group B Streptococcus.

Front Microbiol 2019 23;10:10. Epub 2019 Jan 23.

Department of Microbiology, The Chinese University of Hong Kong, Shatin, Hong Kong.

Group B Streptococcus (GBS; ) is a leading cause of sepsis in neonates and pregnant mothers worldwide. Whereas the hyper-virulent serogroup III clonal cluster 17 has been associated with neonatal disease and meningitis, serogroup III ST283 was recently implicated in invasive disease among non-pregnant adults in Asia. Here, through comparative genome analyses of invasive and non-invasive ST283 strains, we identified a truncated DNA-binding regulator of a two-component system in a non-invasive strain that was homologous to , encoding the response regulator, which was conserved among GBS strains. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00010
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http://dx.doi.org/10.3389/fmicb.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351488PMC
January 2019
4 Reads

Comparing Single vs. Combined Cerebrospinal Fluid Parameters for Diagnosing Full-Term Neonatal Bacterial Meningitis.

Front Neurol 2019 23;10:12. Epub 2019 Jan 23.

Pediatric Infectious Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

To identify and compare the cerebrospinal fluid (CSF) parameters that predict the presence of neonatal bacterial meningitis using optimal cutoff values, and to derive and compare predictive profiles based on a combination of individual parameters for the same purpose. The retrospective component of the Shanghai Neonate Meningitis Cohort included all term neonates who underwent lumbar puncture between 2000 and 2017. Those with severe neurological diseases, histories of ventricular drainage, or traumatic lumbar punctures were excluded. Read More

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http://dx.doi.org/10.3389/fneur.2019.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351467PMC
January 2019
1 Read

MicroRNA-135a participates in the development of astrocytes derived from bacterial meningitis by downregulating HIF-1α.

Am J Physiol Cell Physiol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Accumulating evidence has highlighting the potential of microRNAs (miRs) as biomarkers in various human diseases. However, the roles of miRs in bacterial meningitis (BM), a severe infectious condition, still remain unclear. Thus, the present study aimed to investigate the effects of miR-135a on proliferation and apoptosis of astrocytes in BM. Read More

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http://dx.doi.org/10.1152/ajpcell.00440.2018DOI Listing
February 2019
4 Reads

The Double Life of Group B Streptococcus: Asymptomatic Colonizer and Potent Pathogen.

J Mol Biol 2019 Jan 31. Epub 2019 Jan 31.

Department of Global Health, University of Washington, Seattle, WA, United States of America; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States of America; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States of America. Electronic address:

Group B Streptococcus (GBS) is a β-hemolytic Gram-positive bacterium that colonizes the lower genital tract of approximately 18% of women globally as an asymptomatic member of the gastrointestinal and/or vaginal flora. If established in other host niches, however, GBS is highly pathogenic. During pregnancy, ascending GBS infection from the vagina to the intrauterine space is associated with preterm birth, stillbirth, and fetal injury. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.01.035DOI Listing
January 2019
2 Reads

Escherichia coli-infected cephalohematoma in an infant.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

We report a case of Escherichia coli infection of a cephalohematoma in an infant delivered by vacuum extraction. After excluding potential complications, the patient was treated with intravenous ceftriaxone while hospitalized followed by oral cephalexin after discharge. Infection is a rare but serious complication of cephalohematomas in the newborn period. Read More

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November 2018
4 Reads

Early onset sepsis calculator-based management of newborns exposed to maternal intrapartum fever: a cost benefit analysis.

J Perinatol 2019 Jan 28. Epub 2019 Jan 28.

University of Southern California Leonard D. Schaeffer Center for Health Policy & Economics, Los Angeles, CA, USA.

Objective: To determine potential net monetary benefit of an early onset sepsis calculator-based approach for management of neonates exposed to maternal intrapartum fever, compared to existing guidelines.

Study Design: We performed a cost-benefit analysis comparing two management approaches for newborns >34 weeks gestational age exposed to maternal intrapartum fever. Probabilities of sepsis and meningitis, consequences of infection and antibiotic use, direct medical costs, and indirect costs for long-term disability and mortality were considered. Read More

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http://dx.doi.org/10.1038/s41372-019-0316-yDOI Listing
January 2019
1 Read

Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece.

Infect Dis Rep 2018 Nov 5;10(3):7744. Epub 2018 Dec 5.

Department or Pediatrics, University of Crete, School of Medicine.

Group B streptococcus (GBS) remains a leading cause of neonatal disease. However, GBS rates and prevention strategies vary considerably worldwide. Herein, we investigated the burden and epidemiological trends of neonatal GBS infections in our area (Greece) over the last two decades. Read More

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http://dx.doi.org/10.4081/idr.2018.7744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315311PMC
November 2018
1 Read

Genome sequencing of strains of the most prevalent clonal group of O1:K1:H7 Escherichia coli that causes neonatal meningitis in France.

BMC Microbiol 2019 Jan 17;19(1):17. Epub 2019 Jan 17.

IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.

Background: To describe the temporal dynamics, molecular characterization, clinical and ex vivo virulence of emerging O1:K1 neonatal meningitis Escherichia coli (NMEC) strains of Sequence Type complex (STc) 95 in France. The national reference center collected NMEC strains and performed whole genome sequencing (WGS) of O1:K1 STc95 NMEC strains for phylogenetic and virulence genes content analysis. Data on the clinical and biological features of patients were also collected. Read More

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https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12866-018-1376-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337857PMC
January 2019
4 Reads

A retrospective review of Listeria monocytogenes infection at Tygerberg Children's Hospital, Cape Town, South Africa, from 2006 to 2016: Is empirical ampicillin still indicated after the first month of life?

S Afr Med J 2018 Oct 26;108(11):937-943. Epub 2018 Oct 26.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Ampicillin to treat Listeria monocytogenes (LM) infection is empirically added to the treatment of infants (<3 months) with suspected sepsis or meningitis.

Objectives: In view of limited LM cases, the paucity of South African (SA) data and an ampicillin shortage, our objective was to describe the occurrence of LM infections at Tygerberg Hospital (TBH), Cape Town, with the aim of rationalising the paediatric antibiotic policy.

Methods: An 11-year (2006 - 2016) retrospective descriptive study of children (<13 years) from TBH and referral hospitals with a positive blood or cerebrospinal fluid (CSF) culture for LM was conducted. Read More

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http://dx.doi.org/10.7196/SAMJ.2018.v108i11.13212DOI Listing
October 2018
3 Reads

Rapid and simple universal genotyping method based on Multiple-Locus Variable-Number of Tandem Repeats Analysis using single-tube multiplex PCR and standard gel electrophoresis.

Appl Environ Microbiol 2019 Jan 4. Epub 2019 Jan 4.

Service de Microbiologie, Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP, Paris, France.

We developed a multiplex PCR method based on Multiple-Locus Variable-number of tandem repeats (VNTR)-Analysis (MLVA) designed for rapid typing of and The method amplifying seven VNTRs doesn't require sequencing capillary nor fluorescent dyes. Amplification products are simply loaded on a standard agarose gel for electrophoresis and banding patterns are analyzed visually. We evaluated the method on 220 strains belonging to different collections: ECOR collection (n=72), O1:K1 isolates causing neonatal meningitis (n=38), extended-spectrum beta-lactamase-producing fecal isolates belonging to the worldwide ST131 clone (n=38), Shiga-toxin producing (STEC) of serogroups O157:H7 (n=21) and O26 (n=16, 8 belonging to an outbreak), 27 isolates (22 including 5 epidemic strains) and 8 reference strains. Read More

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http://dx.doi.org/10.1128/AEM.02812-18DOI Listing
January 2019
2 Reads
3.668 Impact Factor

Molecular characterization of an outbreak of enterovirus-associated meningitis in Mossel Bay, South Africa, December 2015-January 2016.

BMC Infect Dis 2018 Dec 29;18(1):709. Epub 2018 Dec 29.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Town, South Africa and the National Health Laboratory Service, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Background: Human enteroviruses (HEVs) are common causal agents of aseptic meningitis in young children. Laboratory and syndromic surveillance during December 2015 and January 2016 noted an unusually high number of paediatric aseptic meningitis cases at a hospital in Mossel Bay, Western Cape Province, South Africa. HEV was detected in clinical samples, prompting an outbreak investigation. Read More

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http://dx.doi.org/10.1186/s12879-018-3641-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311073PMC
December 2018
1 Read

Combination therapy with ciprofloxacin and third-generation cephalosporin versus third-generation cephalosporin monotherapy in Escherichia coli meningitis in infants: a multicentre propensity score-matched observational study.

Clin Microbiol Infect 2018 Dec 27. Epub 2018 Dec 27.

Neonatal Intensive Care Unit, Créteil, France; Centre de Recherche Clinique, Centre Hospitalier Intercommunal de Créteil, Créteil, France; Université Paris Est Créteil, Créteil, France.

Objectives: Escherichiacoli is the second cause of bacterial meningitis in neonates. Despite the use for 35 years of third-generation cephalosporins (3GCs), high morbidity and mortality rates with E. coli meningitis continue to occur. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.12.026DOI Listing
December 2018
1 Read

Emerging Infection with in Neonate. A Case Report.

J Crit Care Med (Targu Mures) 2018 Jul 1;4(3):96-100. Epub 2018 Jul 1.

"Dunarea de Jos" University, Medicine and Pharmacy Research Centre, Galati Romania.

Background: are Gram-negative rod bacteria which are commonly found in the environment. The bacteria have also been associated with nosocomial infections, having been isolated on contaminated medical equipment, especially in neonatal wards.

Case Report: Here, we present the case of a premature female infant born at 33 weeks' gestational age, with neonatal meningitis. Read More

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http://content.sciendo.com/view/journals/jccm/4/3/article-p9
Publisher Site
http://dx.doi.org/10.2478/jccm-2018-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294984PMC
July 2018
7 Reads

Approach to Neonates and Young Infants with Fever without a Source Who Are at Risk for Severe Bacterial Infection.

Mediators Inflamm 2018 26;2018:4869329. Epub 2018 Nov 26.

Pediatrics, Università degli Studi di Milano, Milan, Italy.

Introduction: Among neonates and infants <3 months of age with fever without a source (FWS), 5% to 15% of cases are patients with fever caused by a serious bacterial infection (SBI). To favour the differentiation between low- and high-risk infants, several algorithms based on analytical and clinical parameters have been developed. The aim of this review is to describe the management of young infants with FWS and to discuss the impact of recent knowledge regarding FWS management on clinical practice. Read More

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http://dx.doi.org/10.1155/2018/4869329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287153PMC
November 2018
1 Read

Central Diabetes Insipidus in an Infant with Pneumococcal Meningitis.

Fetal Pediatr Pathol 2018 Dec 22:1-5. Epub 2018 Dec 22.

a Neonatology , University of Health Sciences, Dr Sami Ulus Maternity and Children Health and Research Application Center , Ankara , Türkiye.

Background: Central diabetes is an infrequent complication reported in the neonatal period.

Case Report: CDI as a complication of Streptococcus pneumoniae (S. pneumoniae) sepsis and meningitis in a 9-day-old boy is presented. Read More

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https://www.tandfonline.com/doi/full/10.1080/15513815.2018.1
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http://dx.doi.org/10.1080/15513815.2018.1547335DOI Listing
December 2018
5 Reads

Murine myeloid-derived suppressor cells are a source of elevated levels of interleukin-27 in early life and compromise control of bacterial infection.

Immunol Cell Biol 2018 Dec 21. Epub 2018 Dec 21.

Department of Microbiology, Immunology, & Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.

Microbial infections early in life remain a major cause of infant mortality worldwide. This is consistent with immune deficiencies in this population. Interleukin (IL)-27 is suppressive toward a variety of immune cell types, and we have shown that the production of IL-27 is elevated in humans and mice early in life. Read More

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http://dx.doi.org/10.1111/imcb.12224DOI Listing
December 2018
2 Reads

New molecular tools for meningitis diagnostics in Ethiopia - a necessary step towards improving antimicrobial prescription.

BMC Infect Dis 2018 Dec 20;18(1):684. Epub 2018 Dec 20.

Division for Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Meningitis remains a top cause of premature death and loss of disability-adjusted life years in low-income countries. In resource-limited settings, proper laboratory diagnostics are often scarce and knowledge about national and local epidemiology is limited. Misdiagnosis, incorrect treatment and overuse of antibiotics are potential consequences, especially for viral meningitis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3589-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302510PMC
December 2018
6 Reads
2.613 Impact Factor

The Other Side of the Incubator: A Preemie Turns 40 Years Old.

Authors:
Deborah Discenza

Neonatal Netw 2018 Sep;37(5):324-326

Deb Discenza interviews Geoff, a preemie born almost 40 years ago, and gets unique insight into his birth, his NICU stay, and life afterward. Read More

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http://dx.doi.org/10.1891/0730-0832.37.5.324DOI Listing
September 2018

Klebsiella pneumoniae and Klebsiella oxytoca meningitis in infants. Epidemiological and clinical features.

Arch Pediatr 2019 Jan 14;26(1):12-15. Epub 2018 Dec 14.

Service de pédiatrie, hôpitaux universitaires Paris Seine-Saint-Denis (HUPSSD) site Jean Verdier, université Paris XIII, AP-HP, avenue du 14 Juillet, 93140 Bondy, France; Groupe de pathologie infectieuse pédiatrique, 57, avenue de la Californie, 06200 Nice, France. Electronic address:

Background: The incidence of meningitis caused by Klebsiella pneumoniae (Kp) and Klebsiella oxytoca (Ko) in high-income countries is unknown, and no series have been published to date.

Methods: We conducted a nationwide multicenter observational study in France between 2006 and 2016. All children from the French national registry for paediatric bacterial meningitis under the age of 1 year and hospitalized for Kp or Ko meningitis were included. Read More

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http://dx.doi.org/10.1016/j.arcped.2018.09.013DOI Listing
January 2019
1 Read

Causes of death and predictors of childhood mortality in Rwanda: a matched case-control study using verbal social autopsy.

BMC Public Health 2018 Dec 17;18(1):1378. Epub 2018 Dec 17.

Partners In Health/Inshuti Mu Buzima, Rwinkwavu, Rwanda.

Background: Rwanda has dramatically reduced child mortality, but the causes and sociodemographic drivers for mortality are poorly understood.

Methods: We conducted a matched case-control study of all children who died before 5 years of age in eastern Rwanda between 1st March 2013 and 28th February 2014 to identify causes and risk factors for death. We identified deaths at the facility level and via a community health worker reporting system. Read More

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http://dx.doi.org/10.1186/s12889-018-6282-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296058PMC
December 2018
1 Read

Emerging Infection in Indian Neonatal Intensive Care Units: A Case Report.

Antibiotics (Basel) 2018 Dec 14;7(4). Epub 2018 Dec 14.

Department of Pediatrics, RD Gardi Medical College, Ujjain 456006, India.

Antibiotic-resistant pathogens and nosocomial infections constitute common and serious problems for neonates admitted to neonatal intensive care units worldwide. is a non-lactose-fermenting, gram-negative, health care-associated pathogen (HCAP). It is ubiquitous and intrinsically resistant to several antibiotics. Read More

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http://www.mdpi.com/2079-6382/7/4/109
Publisher Site
http://dx.doi.org/10.3390/antibiotics7040109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316706PMC
December 2018
9 Reads

Distribution of Late-Onset Neonatal Sepsis Pathogens Differs in Inpatient and Outpatient Settings.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, New York University School of Medicine, New York, New York.

Objective:  We sought to examine pathogen distribution and clinical presentation of late-onset sepsis (LOS) at an urban tertiary care center.

Study Design:  We performed a retrospective review of all culture-confirmed cases of LOS presenting to our institution from 2013 to 2017. Medical records were evaluated for demographic information, sepsis risk factors, encounter location, and clinical outcome. Read More

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http://dx.doi.org/10.1055/s-0038-1675643DOI Listing
December 2018
2 Reads

[Neonatal viral meningitis. The importance of the polymerase chain reaction in their diagnosis].

Rev Neurol 2018 Dec;67(12):484-490

Hospital General Universitario de Albacete, 02006 Albacete, Espana.

Introduction: The different types of viral meningitis constitute a condition that is relatively frequent in newborn infants, although in many cases they are underdiagnosed due to the absence of pleocytosis in the cerebrospinal fluid (CSF).

Aims: To describe the clinical features and laboratory findings of newborn infants with viral meningitis and to highlight the importance of the polymerase chain reaction (PCR) in the CSF to diagnose this condition.

Patients And Methods: A retrospective review of the medical records of newborn infants hospitalised in the neonatology section who had been diagnosed with viral meningitis between May 2014 and May 2017. Read More

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December 2018
2 Reads

Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75).

Microbiol Resour Announc 2018 Sep 13;7(10). Epub 2018 Sep 13.

Department of Population Health, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA.

Neonatal meningitis Escherichia coli (NMEC) is the second leading cause of neonatal bacterial meningitis worldwide. We report the genome sequence of the multidrug-resistant NMEC serotype O75:H5:K1 strain mcjchv-1, which resulted in an infant's death. The O75 serogroup is rare among NMEC isolates; therefore, this strain is considered an emergent pathogen. Read More

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http://dx.doi.org/10.1128/MRA.01043-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256591PMC
September 2018
1 Read

Medical Referral Patterns and Etiologies for Children With Mild-to-Severe Hearing Loss.

Ear Hear 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Objectives: To (1) identify the etiologies and risk factors of the patient cohort and determine the degree to which they reflected the incidence for children with hearing loss and (2) quantify practice management patterns in three catchment areas of the United States with available centers of excellence in pediatric hearing loss.

Design: Medical information for 307 children with bilateral, mild-to-severe hearing loss was examined retrospectively. Children were participants in the Outcomes of Children with Hearing Loss (OCHL) study, a 5-year longitudinal study that recruited subjects at three different sites. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000682DOI Listing
December 2018
11 Reads

Epidemiological characterization of serotype group B Streptococci neonatal infections associated with interleukin-6 level as a sensitive parameter for the early diagnosis.

Saudi J Biol Sci 2018 Nov 7;25(7):1356-1364. Epub 2015 Nov 7.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

Group B streptococcal infection () is one of the leading causes of life-threatening disease in the early neonatal period, resulting in sepsis, pneumonia, and meningitis. During invasive infections, an excessive release of pro-inflammatory cytokine, such as interleukin-6 (IL-6), thus IL-6 gene is significant, as a diagnostic marker of systemic infection of the newborns. The present study aimed to describe the epidemiology diagnostic of GBS disease in neonatal by phenotypic and genotypic methods. Read More

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http://dx.doi.org/10.1016/j.sjbs.2015.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252016PMC
November 2018
2 Reads

Risk Factors in Predicting Prognosis of Neonatal Bacterial Meningitis-A Systematic Review.

Front Neurol 2018 20;9:929. Epub 2018 Nov 20.

Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.

Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic factors known to predict adverse outcomes in neonatal bacterial meningitis. Read More

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http://dx.doi.org/10.3389/fneur.2018.00929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255960PMC
November 2018
1 Read

Engineered K1F bacteriophages kill intracellular Escherichia coli K1 in human epithelial cells.

Sci Rep 2018 Dec 3;8(1):17559. Epub 2018 Dec 3.

School of Life Sciences, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, UK.

Bacterial infections can be treated with bacteriophages that show great specificity towards their bacterial host and can be genetically modified for different applications. However, whether and how bacteriophages can kill intracellular bacteria in human cells remains elusive. Here, using CRISPR/Cas selection, we have engineered a fluorescent bacteriophage specific for E. Read More

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http://dx.doi.org/10.1038/s41598-018-35859-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277420PMC
December 2018
1 Read

C-Reactive Protein (CRP) levels in neonatal meningitis in England: an analysis of national variations in CRP cut-offs for lumbar puncture.

BMC Pediatr 2018 Dec 3;18(1):380. Epub 2018 Dec 3.

Department of Paediatrics, Kingston Hospital, Kingston, London, KT2 7QB, UK.

Background: Recent National Institute for Health and Care Excellence (NICE) CG149 guidelines suggest considering performing a lumbar puncture (LP) to investigate for meningitis in early-onset sepsis in a neonate when a C-reactive protein (CRP) level >10mg/L, but the evidence for this recommendation is poorly defined.

Methods: Data on trust-wide LP protocols, neonatal meningitis incidence, lumbar punctures, and CRP levels seen in cases of neonatal meningitis were asked of all 137 trusts in England that recorded a birth in 2017. Our local Kingston Hospital data on every LP performed was obtained to estimate the specificity of CRP rises. Read More

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http://dx.doi.org/10.1186/s12887-018-1354-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276241PMC
December 2018
5 Reads

High frequency of hybrid Escherichia coli strains with combined Intestinal Pathogenic Escherichia coli (IPEC) and Extraintestinal Pathogenic Escherichia coli (ExPEC) virulence factors isolated from human faecal samples.

BMC Infect Dis 2018 Nov 1;18(1):544. Epub 2018 Nov 1.

Department of Zoonotic, Food- and Waterborne Infections, Norwegian Institute of Public Health, Oslo, Norway.

Background: Classification of pathogenic Escherichia coli (E. coli) has traditionally relied on detecting specific virulence associated genes (VAGs) or combinations thereof. For E. Read More

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http://dx.doi.org/10.1186/s12879-018-3449-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267907PMC
November 2018
2 Reads

Virulence factor-dependent basolateral invasion of choroid plexus epithelial cells by pathogenic Escherichia coli in vitro.

FEMS Microbiol Lett 2018 Dec;365(24)

Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.

Escherichia coli is the most common Gram-negative causative agent of neonatal meningitis and E. coli meningitis is associated with high morbidity and mortality. Previous research has been carried out with regard to the blood-brain barrier and thereby unveiled an assortment of virulence factors involved in E. Read More

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https://academic.oup.com/femsle/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/femsle/fny274DOI Listing
December 2018
4 Reads

Multicenter Evaluation of NeuMoDx Group B Assay on the NeuMoDx 288 Molecular System.

J Clin Microbiol 2019 Feb 30;57(2). Epub 2019 Jan 30.

Department of Pathology and Laboratory Medicine, Beaumont Health, Royal Oak, Michigan, USA.

Group B (GBS) is the leading cause of neonatal sepsis and meningitis in developed countries. Recommendations for antepartum GBS detection include enriched culture with several options for identifying GBS, some of which are time-consuming. To reduce the time for identification and determination of the maternal GBS colonization status, rapid nucleic acid amplification technologies have been developed and commercialized. Read More

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http://dx.doi.org/10.1128/JCM.01324-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355512PMC
February 2019
14 Reads

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5.

Emerg Microbes Infect 2018 Nov 21;7(1):185. Epub 2018 Nov 21.

Institute for Biological Products Control, National Institutes for Food and Drug Control, Beijing, China.

As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted to promote CV-B5 vaccine and anti-virus drug research, a 3-day-old BALB/c mouse model was established using a CV-B5 clinical isolate (CV-B5/JS417) as the challenge strain. Read More

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http://dx.doi.org/10.1038/s41426-018-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246558PMC
November 2018
14 Reads

[Adenitis-cellulitis syndrome, an infrequent form of presentation of the late-onset neonatal septicemia: Report of two cases].

Arch Argent Pediatr 2018 Dec;116(6):e769-e772

Universidad de Carabobo, Valencia, Venezuela; Hospital General Universitario, Valencia, España.

Septicemia is the main cause of neonatal mortality. The early-onset neonatal sepsis is usually related to maternal factor risks including recto-vaginal colonization. In the late-onset neonatal septicemia it is more difficult to establish the etiology because the majority of the cases are nosocomial or community related. Read More

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http://dx.doi.org/10.5546/aap.2018.e769DOI Listing
December 2018
6 Reads

Bacterial Meningitis: Bugs' Story.

Indian Pediatr 2018 Oct;55(10):903-904

Department of Pediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.

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October 2018
8 Reads

Acute Community-Acquired Bacterial Meningitis.

Neurol Clin 2018 Nov 20;36(4):809-820. Epub 2018 Sep 20.

Amsterdam UMC, University of Amsterdam, Neurology, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, 1105 AZ Amsterdam, The Netherlands. Electronic address:

Community-acquired bacterial meningitis remains a disease with high impact. The epidemiology of this disease changed substantiality to large-scale introduction of conjugated vaccines. Streptococcus pneumoniae and Neisseria meningitidis are the main causative pathogens outside the neonatal age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183124
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http://dx.doi.org/10.1016/j.ncl.2018.06.007DOI Listing
November 2018
15 Reads

A fatal case of enterovirus infection with secondary hemophagocytosis-case report with review of literature.

APMIS 2018 Nov;126(11):877-882

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Enterovirus is a common viral infection, which can affect multiple organ systems with an array of clinical presentation such as meningitis, encephalitis, myocarditis, and disseminated infections. The illness is usually asymptomatic and self-limited but few cases can be severe and life-threatening especially when associated with hemophagocytosis. We discuss a fatal case of disseminated enterovirus infection and the histomorphological features of the infection. Read More

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http://doi.wiley.com/10.1111/apm.12892
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http://dx.doi.org/10.1111/apm.12892DOI Listing
November 2018
19 Reads
1.922 Impact Factor

Innate Immunity Evasion by Enteroviruses Linked to Epidemic Hand-Foot-Mouth Disease.

Front Microbiol 2018 8;9:2422. Epub 2018 Oct 8.

Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China.

Enterovirus (EV) infections are a major threat to global public health, and are responsible for mild respiratory illness, hand, foot, and mouth disease (HFMD), acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis epidemic. Among them, HFMD is a common pediatric infectious disease caused by EVs of the family including EV-A71, coxsackieviruses (CV)-A2, CV-A6, CV-A10, and CV-A16. Due to lack of vaccines and specific antiviral therapeutics, millions of children still suffer from HFMD. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02422
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http://dx.doi.org/10.3389/fmicb.2018.02422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186807PMC
October 2018
14 Reads

The hearing screening experiences and practices of primary health care nurses: Indications for referral based on high-risk factors and community views about hearing loss.

Afr J Prim Health Care Fam Med 2018 Oct 10;10(1):e1-e11. Epub 2018 Oct 10.

Discipline of Audiology, University of KwaZulu-Natal.

Background:  In South Africa, primary health care is the first point of contact with the health system for at least 85% of the population, yet early hearing detection and intervention continues to be elusive in these settings. Nurses at community level may, therefore, be missing an opportunity to identify prelingual infants with hearing losses and alter their developmental trajectory.

Aim:  To determine primary health care nurses' experiences, practices and beliefs regarding hearing loss in infants. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191740PMC
http://dx.doi.org/10.4102/phcfm.v10i1.1848DOI Listing
October 2018
2 Reads

New insights into Citrobacter freundii Sepsis in Neonates.

Authors:
Dan Chen Yalian Ji

Pediatr Int 2018 Oct 16. Epub 2018 Oct 16.

Department of Neonatology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province, China, 110004.

Background: This study aimed to investigate the clinical features of neonatal sepsis caused by Citrobacter freundii as well as the current status and treatment strategy of multi-drug resistance for infection with this bacterium.

Methods: Nine newborns were diagnosed with C. freundii sepsis between January 2014 and December 2017,we collated and analysed a range of data of the nine patients, including general information,laboratory tests during infection,blood culture and treatments. Read More

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http://dx.doi.org/10.1111/ped.13715DOI Listing
October 2018
2 Reads

Rare meningitis case in a Danish male.

JMM Case Rep 2018 Aug 9;5(8):e005163. Epub 2018 Aug 9.

Department of Infectious Diseases, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark.

Introduction: is a Gram-negative, aerobic, non-motile rod belonging to the family . Over the last 5 years, it has emerged as an opportunistic human pathogen involved in neonatal meningitis and sepsis, as well as nosocomial outbreaks. It has been isolated from the midgut of the mosquito, but there is no evidence for a role of the mosquito in human infections, and very little is known regarding the routes of transmission to humans. Read More

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http://www.microbiologyresearch.org/content/journal/jmmcr/10
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http://dx.doi.org/10.1099/jmmcr.0.005163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152398PMC
August 2018
10 Reads

Virulence and Antibiotic Resistance Profiles of and spp. Involved in the Diarrheic Hemorrhagic Outbreak in Mexico.

Front Microbiol 2018 27;9:2206. Epub 2018 Sep 27.

Foodmicrobe.com, Nottingham, United Kingdom.

spp. are bacterial pathogens that cause neonatal meningitis, septicemia, and necrotizing enterocolitis in infants with a lethality rate of 40-80%. Powdered infant formulas (PIF) have been implicated as the main vehicles of transmission. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171480PMC
September 2018
2 Reads

Cerebrospinal fluid hydrocele caused by scrotal migration of a ventriculoperitoneal shunt.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Radiology, Aga Khan University, Karachi, Sindh, Pakistan.

A 6-month-old boy presented with painless right hemiscrotal swelling. The scrotal ultrasound revealed a cerebrospinal fluid hydrocele caused by the migration of a ventriculoperitoneal shunt (VPS) catheter tip into the right hemiscrotum and associated undescended left testis. Earlier, he underwent a VPS placement for hydrocephalus secondary to neonatal bacterial meningitis and ventriculitis. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22469
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http://dx.doi.org/10.1136/bcr-2018-224698DOI Listing
October 2018
14 Reads

Characterization of the pathogenicity of clinical Cronobacter malonaticus strains based on the tissue culture investigations.

Antonie Van Leeuwenhoek 2018 Oct 12. Epub 2018 Oct 12.

foodmicrobe.com, Adams Hill, Keyworth, Nottinghamshire, NG12 5GY, UK.

Cronobacter malonaticus is a member of the genus Cronobacter which is considered an opportunistic pathogen. The significance of C. malonaticus has recently increased since it was documented to be involved in several serious neonatal infections. Read More

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http://dx.doi.org/10.1007/s10482-018-1178-6DOI Listing
October 2018
2 Reads

Discovery of -Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage.

mSphere 2018 10 10;3(5). Epub 2018 Oct 10.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

Resistance to last-line polymyxins mediated by the plasmid-borne mobile colistin resistance gene () represents a new threat to global human health. Here we present the complete genome sequence of an -positive multidrug-resistant strain (MS8345). We show that MS8345 belongs to serotype O2:K1:H4, has a large 241,164-bp IncHI2 plasmid that carries 15 other antibiotic resistance genes (including the extended-spectrum β-lactamase ) and 3 putative multidrug efflux systems, and contains 14 chromosomally encoded antibiotic resistance genes. Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphere.00486-18
Publisher Site
http://dx.doi.org/10.1128/mSphere.00486-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180223PMC
October 2018
13 Reads