8,926 results match your criteria Neonatal Meningitis


A Rare Case of an Intramedullary Spinal Cord Abscess Due to Escherichia coli in a Pediatric Patient.

Child Neurol Open 2021 Jan-Dec;8:2329048X211011869. Epub 2021 Jun 1.

Department of Pediatrics, Loyola University Medical Center, Maywood, IL, USA.

Spinal cord abscess is a rare entity, particularly in the pediatric population. Spinal cord abscesses can be located in extradural, subdural and intradural (intramedullary or extramedullary) regions of the cord. Among these locations, intramedullary is extremely uncommon. Read More

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in pregnancy and the impact of recommendations on adherence to guidelines: an Italian area-based study.

J Matern Fetal Neonatal Med 2021 Jun 10:1-5. Epub 2021 Jun 10.

Dipartimento Materno-Infantile ASL VCO, Verbania, Italia.

Introduction: Streptococcus agalactiae, a species of β-haemolytic streptococcus belonging to Lancefield's group B (GBS), is known as a common infecting agent transmitted to infants during childbirth, causing sepsis, meningitis, or both, with a high incidence of mortality. Following the observation of a great variability between regional laboratories both in the methodology and in the results of tests for the detection of GBS in pregnancy, with high percentages of false negative results, in 2010 the Department for Health Policies of Piedmont, Italian region, issued specific recommendations for adhere to international guidelines. Our aim was to assess whether the impact of the publication of the recommendations has been lasting over time. Read More

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Determining Anterior Fontanel Size and Associated Factors Among Term Neonates on the First Day of Life Born at Jimma University Medical Center (JUMC), Southwest Ethiopia: A Linear Regression Model.

Pediatric Health Med Ther 2021 1;12:269-278. Epub 2021 Jun 1.

School of Medicine, College of Health and Medical Science, Haramaya University, Harar, Ethiopia.

Background: Knowledge of the normal variation in AF size may be helpful to cue early diagnosis of congenital hypothyroidism, hyperthyroidism, cardiac disease, meningitis, degree of dehydration or provide a clue to disorders of neural and skeletal development. However, the data is scarce. Therefore, this study was aimed to determine AF size and associated factors among term neonates on the first day of life born in Jimma University Medical Center (JUMC), Southwest Ethiopia. Read More

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Pathogenic mechanism, detection methods and clinical significance of group B .

Future Microbiol 2021 Jun 8;16:671-685. Epub 2021 Jun 8.

Department of Central Lab, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong, 264200, PR China.

Group B (GBS) is the main pathogen of perinatal infection. It can lead to adverse pregnancy, maternal infection, premature delivery, abortion, stillbirth and a series of adverse maternal and infant outcomes such as neonatal sepsis, meningitis or pneumonia during delivery. In order to reduce the infection of perinatal pregnant and the adverse pregnancy outcome, more attention should be paid in the clinical practice, screening efforts, universal detection of GBS infection for pregnant women and preventive treatment for the possible mother infant infection. Read More

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Stable Incidence of Invasive Pneumococcal Disease in Children in Northern France From 2014 Through 2018.

Pediatr Infect Dis J 2021 Jul;40(7):688-693

From the CHU Lille, Pediatric Emergency Unit and Infectious Diseases.

Background: The 13-valent pneumococcal conjugate vaccine (PCV13) has been recommended in France since June 2010. The aim of this study was to evaluate the trends in the incidence of invasive pneumococcal disease (IPD) resulting in hospitalization of children younger than 18 years of age, to identify the vaccination status of these patients and to analyze the serotypic evolution of the pneumococci involved in the various types of IPD.

Methods: This multicenter retrospective study reviewed all admissions of children younger than 18 years of age for IPD from 2014 through 2018 in all hospitals with a pediatric or neonatal unit in northern France. Read More

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Pediatric sepsis cases diagnosed with group B streptococcal meningitis using next-generation sequencing: a report of two cases.

BMC Infect Dis 2021 Jun 5;21(1):531. Epub 2021 Jun 5.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Group B Streptococcus (GBS) is an important cause of invasive infection in neonates and infants. Cerebrospinal fluid (CSF) findings and culture may not show evidence of infection early in GBS meningitis. Next-generation sequencing (NGS) has the potential to detect microbial genetic material in patients with infectious diseases. Read More

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Development and Validation of Enzyme-Linked Immunosorbent Assay for Group B Streptococcal Polysaccharide Vaccine.

Vaccines (Basel) 2021 May 21;9(6). Epub 2021 May 21.

Department of Internal Medicine, Division of Infectious Diseases, Korea University College of Medicine, Seoul 08308, Korea.

(group B , GBS) is a leading cause of neonatal sepsis and meningitis in infants. Limitations of prenatal GBS screening and intrapartum antibiotic prophylaxis render developing GBS vaccines a high priority. In this study, we developed an enzyme-linked immunosorbent assay (ELISA) for the practical and large-scale evaluation of GBS capsular polysaccharide (PS) vaccine immunogenicity against three main serotypes, Ia, III, and V. Read More

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Necrotizing Funisitis as an Intrauterine manifestation of Cryopyrin-Associated Periodic Syndrome: a case report and review of the literature.

Pediatr Rheumatol Online J 2021 May 31;19(1):77. Epub 2021 May 31.

Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Cryopyrin-associated periodic syndrome (CAPS) is a life-long, autoinflammatory disease associated with a gain-of-function mutation in the nucleotide-binding domain, leucine-rich repeat family, pyrin domain containing 3 (NLRP3) gene, which result in uncontrolled production of IL-1β and chronic inflammation. Chronic infantile neurologic cutaneous and articular (CINCA) syndrome/neonatal-Onset multisystem inflammatory disease (NOMID) is the most severe form of CAPS. Although the first symptoms may be presented at birth, there are few reports on the involvement of the placenta and umbilical cord in the disease. Read More

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Intrinsically Resistant Bacteria as Looming Disaster: A Rare Case Report of Meningitis in a Neonate.

J Lab Physicians 2021 Mar 22;13(1):70-73. Epub 2021 Feb 22.

Department of Neonatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

is a recognized cause of neonatal meningitis with high mortality rate of approximately 57%, but clinical data detailing these infections remain limited from India. Though this bacteria has a Gram-negative character, it is usually multidrug resistant to antibiotics usually prescribed for Gram-negative bacterial infections and susceptible to antibiotics for Gram-positive bacteria, thus poses a serious challenge to the treating clinicians. Such cases of neonatal meningitis is most commonly associated with prematurity with birth weight < 2,500 g, but here we report an uncommon case of neonatal meningitis due to this rare pathogen in a full-term neonate with weight as per gestational age. Read More

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Perinatal Infections With Ureaplasma.

Pediatr Infect Dis J 2021 May;40(5S):S26-S30

From the Division of Pediatric Infectious Diseases, Immunology and Rheumatology, Department of Pediatrics.

Ureaplasma species are increasingly recognized as relevant pathogens in prenatal, perinatal and postnatal morbidity. They are commonly found as commensals on the mucous membranes of the lower urogenital tract of pregnant women, but when ascending, they can cause bacterial vaginosis, chorioamnionitis, premature birth and postnatal morbidities such as bronchopulmonary dysplasia, and early-onset neonatal sepsis and meningitis. The detection of Ureaplasma species is challenging and is not covered by routine diagnostics, and current empiric antibiotic treatment in neonates suspected of infection is not directed against Ureaplasma species. Read More

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and co-infection in a newborn.

Trop Doct 2021 May 27:494755211017419. Epub 2021 May 27.

Intensive Care Medicine, ESE Hospital Universitario San Jorge de Pereira, Pereira, Colombia.

Invasive infections due to in Colombia are unusual in newborns, in contrast to infections due to which is one of the main pathogens related to the presentation of fever in this age group, especially in the indigenous population. We report a case of co-infection of these two microorganisms in a child. Read More

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Association of Infection in Neonates and Long-Term Neurodevelopmental Outcome.

Clin Perinatol 2021 Jun;48(2):251-261

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 800 Spruce Street, 2nd Floor Cathcart Building, Newborn Medicine, Philadelphia, PA, USA. Electronic address:

Perinatal and neonatal infection and associated inflammatory response may adversely affect brain development and lead to neurodevelopmental impairment. Factors that predict the risk of infection and subsequent adverse outcomes have been identified but substantial gaps remain in identifying mechanisms and interventions that can alter outcomes. This article describes the current epidemiology of neonatal sepsis, the pathogenesis of brain injury with sepsis, and the reported long-term neurodevelopment outcomes among survivors. Read More

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Prevalence and predictors of adverse outcomes in neonatal seizures.

J Neonatal Perinatal Med 2021 May 18. Epub 2021 May 18.

Department of Biochemistry, University College of Medical sciences and Guru Teg Bahadur Hospital, Delhi, India.

Objectives: Neonatal seizures are significant cause of neonatal mortality and morbidity. Current study was planned to study prevalence of adverse outcomes in neonatal seizures and identify its predictors.

Methods: This observational descriptive study was carried out on 220 neonates with seizures. Read More

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Clinical profile, aetiology, short-term outcome and predictors of poor outcome of neonatal seizures among out-born neonates admitted to a neonatal unit in Paediatric emergency of a tertiary care hospital in North India: A prospective observational study.

Trop Doct 2021 May 21:494755211016226. Epub 2021 May 21.

Assistant Professor, Division of Paediatric Critical Care, Department of Paediatrics, Advanced Paediatric Centre, Postgraduate Institute of Medical Education and Research (29751PGIMER), Chandigarh, India.

Neonatal seizures are common manifestations of several neurological or systemic disorders and associated with high morbidity, mortality and poor short- and long-term developmental outcomes. It is important to determine the aetiology and factors that determine the poor outcome, more so in a newly developed setting. The early detection of predictors of poor outcome will help in planning acute management, counselling, follow-up and rehabilitation services. Read More

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Etiology of Neonatal Bacterial Meningitis and Their Antibiotic Susceptibility Pattern at the University of Gondar Comprehensive Specialized Hospital, Ethiopia: A Seven-Year Retrospective Study.

Infect Drug Resist 2021 10;14:1703-1711. Epub 2021 May 10.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.

Background: Meningitis, which is mostly caused by infectious agents, occurs more commonly during the first month of life. Bacterial meningitis is an important source of mortality and morbidity, especially in neonates of resource-limited countries. We aimed to determine the prevalence and etiological agents of bacterial meningitis and their antibiotic susceptibility pattern in neonates at the University of Gondar Comprehensive Specialized Hospital. Read More

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Ureaplasma urealyticum meningitis complicated by hydrocephalus in a preterm neonate.

J Paediatr Child Health 2021 May 18. Epub 2021 May 18.

Department of Infectious Diseases, Perth Children's Hospital, Perth, Western Australia, Australia.

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Antibiotic regimens for late-onset neonatal sepsis.

Cochrane Database Syst Rev 2021 05 8;5:CD013836. Epub 2021 May 8.

Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region of Denmark, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Neonatal sepsis is a major cause of morbidity and mortality. It is the third leading cause of neonatal mortality globally constituting 13% of overall neonatal mortality. Despite the high burden of neonatal sepsis, high-quality evidence in diagnosis and treatment is scarce. Read More

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Prevalence and Antimicrobial Susceptibility of Isolated from Clinical Samples in the Past 8 Years in Korea.

Biomed Res Int 2021 28;2021:6615334. Epub 2021 Apr 28.

Department of Public Health, Dankook University Graduate School, 119 Dandae-ro, Dongnan-Gu, Cheonan-Si, Chungnam 31116, Republic of Korea.

Pneumococcal infection is the main causative agent of pneumonia, meningitis, and sepsis in immunocompromised and elderly people. The samples in this study were collected from subjects in an 800-bed hospital in Chungnam province, Korea, over the past 8 years. Of the 473,230 samples obtained for microbial culture from 2012 to 2019, was isolated from 714 samples collected from 702 patients, with a pneumococcal-positive rate of 0. Read More

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A case of facial cellulitis caused by group B streptococcus in an extremely low birthweight infant.

J Infect Chemother 2021 May 11. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Center for Perinatal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Group B streptococcus (GBS) is an important pathogen that causes neonatal sepsis and meningitis, which have high mortality and morbidity. Cellulitis is a rare presentation of late-onset neonatal GBS infection. We report the case of an extremely low birthweight infant with facial cellulitis caused by late-onset GBS infection. Read More

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Listeria infection in young infants: results from a national surveillance study in the UK and Ireland.

Arch Dis Child 2021 May 13. Epub 2021 May 13.

Paediatric Infectious Disease Research Group, University of London Saint George's, London, UK.

Objectives: To describe the epidemiology, age at infection, clinical characteristics and outcome of listeria infection in young infants to inform management and empiric antibiotic choice in young infants.

Design: Prospective 2-year surveillance of infection in young infants detected through the British Paediatric Surveillance Unit 'orange card' system and triangulated with the public health laboratories.

Setting: National population study (England, Wales, Scotland and the Ireland) PATIENTS: All infants under 90 days with proven or probable invasive listeriosis MAIN OUTCOME MEASURES: Incidence, mortality, age of infection, clinical characteristics and outcome RESULTS: During a 2-year period (2017-2019), 27 cases of listeriosis in infants <90 days of age were reported. Read More

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Real-Time Quantification of Reactive Oxygen Species in Neutrophils Infected with Meningitic Escherichia Coli.

J Vis Exp 2021 04 20(170). Epub 2021 Apr 20.

Department of Developmental Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University;

Escherichia coli (E. coli) is the most common Gram-negative bacteria causing neonatal meningitis. The occurrence of bacteremia and bacterial penetration through the blood-brain barrier are indispensable steps for the development of E. Read More

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Deviations in the gut microbiota of neonates affected by maternal group B Streptococcus colonization.

BMC Microbiol 2021 May 5;21(1):140. Epub 2021 May 5.

Departments of Obstetrics and Gynecology, Shenzhen Luohu Maternity and Child Health Hospital, No.2013, Taibai Road, Luohu District, Shenzhen, 518019, China.

Background: Group B Streptococcus (GBS) infection is the leading cause of septicemia, meningitis, and pneumonia in neonates. Aberrant gut colonization in early life may predispose children to various diseases in adulthood. However, the associations between gut microbial changes and GBS colonization is still unclear. Read More

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Clinical characterization of benign enterovirus infection in neonates.

Medicine (Baltimore) 2021 May;100(18):e25706

Department of Neonatology, Zhangzhou Hospital, Zhangzhou, Fujian, China.

Abstract: Enteroviruses is a group of positive single-stranded RNA viruses ubiquitous in the environment, which is a causative agent of epidemic diseases in children and infants. But data on neonates are still limited. The present study aimed to describe the clinical characteristics of enterovirus infection in neonates and arise the awareness of this disease to general public. Read More

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Cerebral Venous Sinus Thrombosis in Children: A Study from a Tertiary Care Hospital of Eastern India.

J Pediatr Neurosci 2020 Oct-Dec;15(4):370-374. Epub 2021 Jan 19.

Department of Neurology, Srirama Chandra Bhanja Medical College & Hospital (SCBMCH), Cuttack, Odisha, India.

Context: Cerebral venous sinus (sinovenous) thrombosis (CVST) in childhood is a rare, but under recognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%.

Aim: The aim of this study was to enlist the patients diagnosed as CVST younger than 14 years of age and to diagnose the etiology along with radiological correlation.

Settings And Design: This prospective clinical study was conducted for 2 years in the Department of Neurology, Srirama Chandra Bhanja Medical College & Hospital (SCBMCH), Cuttack, Odisha, India. Read More

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January 2021

Avian Pathogenic (APEC): An Overview of Virulence and Pathogenesis Factors, Zoonotic Potential, and Control Strategies.

Pathogens 2021 Apr 12;10(4). Epub 2021 Apr 12.

Center for Food Animal Health, Department of Animal Sciences, The Ohio State University, Wooster, OH 44691, USA.

Avian pathogenic (APEC) causes colibacillosis in avian species, and recent reports have suggested APEC as a potential foodborne zoonotic pathogen. Herein, we discuss the virulence and pathogenesis factors of APEC, review the zoonotic potential, provide the current status of antibiotic resistance and progress in vaccine development, and summarize the alternative control measures being investigated. In addition to the known virulence factors, several other factors including quorum sensing system, secretion systems, two-component systems, transcriptional regulators, and genes associated with metabolism also contribute to APEC pathogenesis. Read More

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Vaccines to Prevent Meningitis: Historical Perspectives and Future Directions.

Microorganisms 2021 Apr 7;9(4). Epub 2021 Apr 7.

Center for Vaccine Innovation and Access, PATH, Seattle, WA 98121, USA.

Despite advances in the development and introduction of vaccines against the major bacterial causes of meningitis, the disease and its long-term after-effects remain a problem globally. The Global Roadmap to Defeat Meningitis by 2030 aims to accelerate progress through visionary and strategic goals that place a major emphasis on preventing meningitis via vaccination. Global vaccination against type B (Hib) is the most advanced, such that successful and low-cost combination vaccines incorporating Hib are broadly available. Read More

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Nitroglycerin patch use in digital ischemia secondary to sepsis: a case report.

Pan Afr Med J 2021 3;38:114. Epub 2021 Feb 3.

Neonatal Intensive Care Unit, Al Jalila Children´s Specialty Hospital, Dubai, United Arab Emirates.

Sepsis results in intense disturbances in homoeostasis and is responsible for considerable morbidity and mortality in early infancy. Owing to insufficiency on part of infant to develop adequate inflammatory response to localize the infection, they usually progress to disseminated systemic infection, pneumonia and/or meningitis. We present the case of a 26 weeks preterm boy with acute digital ischemia in right index finger progressing to impending gangrene as a manifestation of septicemia. Read More

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Investigation of primary immune deficiency after severe bacterial infection in children: A population-based study in western France.

Arch Pediatr 2021 Jul 24;28(5):398-404. Epub 2021 Apr 24.

CHU de Nantes, Department of Pediatrics, Nantes, France.

Background: Infectious diseases are still an important cause of morbidity and mortality in high-income countries and may preferentially affect predisposed children, especially immunocompromised children. We aimed to evaluate the frequency of recommended immunological tests in children with community-onset severe bacterial infection (COSBI) admitted to a pediatric intensive care unit. We also assessed the frequency and described the typology of diagnosed primary immune deficiency (PID). Read More

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Cost-effectiveness of maternal immunization against neonatal invasive Group B Streptococcus in the Netherlands.

Vaccine 2021 05 22;39(21):2876-2885. Epub 2021 Apr 22.

National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control (Cib), Bilthoven, the Netherlands.

Background: Neonatal invasive Group B Streptococcus (GBS) infection causes considerable disease burden in the Netherlands. Intrapartum antibiotic prophylaxis (IAP) prevents early-onset disease (EOD), but has no effect on late-onset disease (LOD). A potential maternal GBS vaccine could prevent both EOD and LOD by conferring immunity in neonates. Read More

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