9,202 results match your criteria Neonatal Meningitis

Collaborative Action of Microglia and Astrocytes Mediates Neutrophil Recruitment to the CNS to Defend against K1 Infection.

Int J Mol Sci 2022 Jun 11;23(12). Epub 2022 Jun 11.

The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.

K1 is a leading cause of neonatal bacterial meningitis. Recruitment of neutrophils to the central nervous system (CNS) via local immune response plays a critical role in defense against K1 infection; however, the mechanism underlying this recruitment remains unclear. In this study, we report that microglia and astrocytes are activated in response to stimulation by K1 and/or K1-derived outer membrane vesicles (OMVs) and work collaboratively to drive neutrophil recruitment to the CNS. Read More

View Article and Full-Text PDF

Perforated Neonatal Appendicits With Associated Intraperitoneal Abscess and Bacterial Meningitis: The Case of the Baby Who Would Not Stay Well.

Clin Pediatr (Phila) 2022 Jun 16:99228221104364. Epub 2022 Jun 16.

Division of Pediatric Hospital Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

View Article and Full-Text PDF

An Model of Echovirus-Induced Meningitis Defines the Differential Roles of Type I and Type III Interferon Signaling in Central Nervous System Infection.

J Virol 2022 Jun 14:e0033022. Epub 2022 Jun 14.

Department of Molecular Genetics and Microbiology, Duke University School of Medicinegrid.471396.e, Durham, North Carolina, USA.

Echoviruses are among the most common worldwide causes of aseptic meningitis, which can cause long-term sequelae and death, particularly in neonates. However, the mechanisms by which these viruses induce meningeal inflammation are poorly understood, owing at least in part to the lack of models that recapitulate this aspect of echovirus pathogenesis. Here, we developed an neonatal mouse model that recapitulates key aspects of echovirus-induced meningitis. Read More

View Article and Full-Text PDF

Three Years of Vestibular Infant Screening in Infants With Sensorineural Hearing Loss.

Pediatrics 2022 Jun 14. Epub 2022 Jun 14.

Faculty of Medicine and Health Sciences, Departments of Rehabilitation Sciences.

Objectives: Although vestibular deficits are more prevalent in hearing-impaired children and can affect their development on many levels, a pediatric vestibular assessment is still uncommon in clinical practice. Since early detection may allow for timely intervention, this pioneer project has implemented a basic vestibular screening test for each six-month-old hearing-impaired infant in Flanders, Belgium. This study aims to report the vestibular screening results over a period of three years and to define the most important risk factors for abnormal vestibular screening results. Read More

View Article and Full-Text PDF

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children.

JAMA Netw Open 2022 Jun 1;5(6):e2216778. Epub 2022 Jun 1.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Centre of Research in Epidemiology and Statistics, Université Paris Cité, Paris, France.

Importance: Assessment of the quality of initial care is necessary to target priority actions that can reduce the still high morbidity and mortality due to community-onset severe bacterial infections (COSBIs) among children.

Objective: To study the prevalence, characteristics, and determinants of suboptimal care in the initial management of COSBIs.

Design, Setting, And Participants: This prospective, population-based, cohort study and confidential enquiry was conducted between August 2009 and January 2014 in western France, a region accounting for 15% of the French pediatric population (1 968 474 children aged 1 month to 16 years) and including 6 pediatric intensive care units (PICUs) and 35 emergency departments. Read More

View Article and Full-Text PDF

Rochester Criteria and Yale Observation Scale Score to Evaluate Febrile Neonates with Invasive Bacterial Infection.

J Emerg Med 2022 Jun 9. Epub 2022 Jun 9.

State University of New York Downstate Medical Center, Brooklyn, New York; Kings County Hospital New York Health and Hospitals, Brooklyn, New York.

Background: Febrile neonates undergo lumbar puncture (LP), empiric antibiotic administration, and admission for increased risk of invasive bacterial infection (IBI), defined as bacteremia and meningitis.

Objective: Measure IBI prevalence in febrile neonates, and operating characteristics of Rochester Criteria (RC), Yale Observation Scale (YOS) score, and demographics as a low-risk screening tool.

Methods: Secondary analysis of healthy febrile infants < 60 days old presenting to any of 26 emergency departments in the Pediatric Emergency Care Applied Research Network between December 2008 and May 2013. Read More

View Article and Full-Text PDF

Clinical and Neurodevelopmental Characteristics of and Meningitis in Neonates.

Front Pediatr 2022 20;10:881516. Epub 2022 May 20.

Medical and Surgical Department of Fetus-Newborn-Infant, "Bambino Gesù" Children's Hospital Scientific Hospitalization and Treatment Institute (IRCCS), Rome, Italy.

Background: Non-polio-enteroviruses (EV) and human parechoviruses (HPeV) are small RNA viruses, which in newborns cause infections with a wide range of severity. Today molecular biology tools allow us to diagnose viral meningitis in neonates, sparing patients from useless antibiotics. Data on neurodevelopmental outcome of children who contract enterovirus meningitis in early childhood are still limited in the literature. Read More

View Article and Full-Text PDF

Causes of deaths in neonates and children aged 1-59 months in Nigeria: verbal autopsy findings of 2019 Verbal and Social Autopsy study.

BMC Public Health 2022 Jun 6;22(1):1130. Epub 2022 Jun 6.

Social Solutions International, Rockville, USA.

Background: Nigeria has one of the highest under-five mortality rates in the world. Identifying the causes of these deaths is crucial to inform changes in policy documents, design and implementation of appropriate interventions to reduce these deaths. This study aimed to provide national and zonal-level estimates of the causes of under-five death in Nigeria in the 2013-2018 periods. Read More

View Article and Full-Text PDF

Comparative Genomic Analysis of Type VII Secretion System in Indicates Its Possible Sequence Type-Dependent Diversity.

Front Cell Infect Microbiol 2022 19;12:880943. Epub 2022 May 19.

Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

causes sepsis and meningitis in neonates, presenting substantial clinical challenges. Type VII secretion system (T7SS), an important secretion system identified in sp. and Gram-positive bacteria, was recently characterized in and considered to contribute to its virulence and pathogenesis. Read More

View Article and Full-Text PDF

Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization.

mBio 2022 Jun 6:e0098522. Epub 2022 Jun 6.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Group B Streptococcus (GBS) is associated with severe infections and in newborn populations, including pneumonia, sepsis, and meningitis. GBS vaginal colonization of the pregnant mother is an important prerequisite for transmission to the newborn and the development of neonatal invasive disease; however, our understanding of the factors required for GBS persistence and ascension in the female reproductive tract (FRT) remains limited. Here, we utilized a GBS transposon () mutant library previously developed by our group and identified underrepresented mutations in 535 genes that contribute to survival within the vaginal lumen and colonization of vaginal, cervical, and uterine tissues. Read More

View Article and Full-Text PDF

Diagnostic Utility of Cerebrospinal Fluid Procalcitonin in Neonatal Meningitis.

J Trop Pediatr 2022 04;68(3)

Department of Neonatology, Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, New Delhi 110001, India.

We aimed to study the diagnostic utility of cerebrospinal fluid (CSF) procalcitonin (PCT) in neonates with meningitis. All the neonates with sepsis who qualified for lumbar puncture were prospectively evaluated. The neonates were classified into Meningitis and No meningitis group based on predefined criteria. Read More

View Article and Full-Text PDF

Cerebrospinal fluid and plasma procalcitonin for the diagnosis of neonatal bacterial meningitis.

J Paediatr Child Health 2022 Jun 2. Epub 2022 Jun 2.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aim: There is a paucity of data on cerebrospinal fluid (CSF) procalcitonin (PCT) to diagnose neonatal meningitis. We evaluated CSF PCT to diagnose bacterial meningitis among neonates with suspected sepsis.

Methods: Neonates undergoing lumbar puncture (LP) as part of sepsis workup were included. Read More

View Article and Full-Text PDF

Pharmacotherapy of Generalized Myasthenia Gravis with Special Emphasis on Newer Biologicals.

Drugs 2022 Jun 31;82(8):865-887. Epub 2022 May 31.

Ellen and Martin Prosserman Centre for Neuromuscular Diseases, University Health Network, 5EC-309, Toronto General Hospital, University of Toronto, 200 Elizabeth St, Toronto, M5G 2C4, Canada.

Myasthenia gravis (MG) is a chronic, fluctuating, antibody-mediated autoimmune disorder directed against the post-synaptic neuromuscular junctions of skeletal muscles, resulting in a wide spectrum of manifestations ranging from mild to potentially fatal. Given its unique natural course, designing an ideal trial design for MG has been wrought with difficulties and evidence in favour of several of the conventional agents is weak as per current standards. Despite this, acetylcholinesterases and corticosteroids have remained the cornerstones of treatment for several decades with intravenous immunoglobulins (IVIG) and therapeutic plasma exchange (PLEX) offering rapid treatment response, especially in crises. Read More

View Article and Full-Text PDF

Proteins Involved in Synaptic Plasticity Are Downregulated in the Cerebrospinal Fluid of Infants With Clinical Sepsis Complicated by Neuroinflammation.

Front Cell Neurosci 2022 11;16:887212. Epub 2022 May 11.

Department of Neonatology, Bao'an Women and Children's Hospital, Jinan University, Shenzhen, China.

Newborn infants are prone to sepsis and related inflammation of different organs. Neuroinflammation has been associated with long-term adverse neuronal (neuropsychiatric/neurodegenerative) outcomes, including attention deficit hyperactivity disorder (ADHD) or even Alzheimer's disease. Despite a vast number of findings on sepsis-induced inflammatory responses in the central nervous system (CNS), how neuroinflammation affects brain development remains largely elusive. Read More

View Article and Full-Text PDF

RpoE Facilitates Stress-Resistance, Invasion, and Pathogenicity of K1.

Microorganisms 2022 Apr 22;10(5). Epub 2022 Apr 22.

The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.

K1 is the most common Gram-negative bacterium that causes neonatal meningitis; thus, a better understanding of its pathogenic molecular mechanisms is critical. However, the mechanisms by which K1 senses the signals of the host and expresses toxins for survival are poorly understood. As an extracytoplasmic function sigma factor, RpoE controls a wide range of pathogenesis-associated pathways in response to environmental stress. Read More

View Article and Full-Text PDF

YbdO Promotes the Pathogenicity of K1 by Regulating Capsule Synthesis.

Int J Mol Sci 2022 May 16;23(10). Epub 2022 May 16.

The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin 300457, China.

K1 is the most popular neonatal meningitis-causing Gram-negative bacterium. As a key virulence determinant, the K1 capsule enhances the survival of K1 in human brain microvascular endothelial cells (HBMECs) upon crossing the blood-brain barrier; however, the regulatory mechanisms of capsule synthesis during K1 invasion of HBMECs remain unclear. Here, we identified YbdO as a transcriptional regulator that promotes K1 invasion of HBMECs by directly activating K1 capsule gene expression to increase K1 capsule synthesis. Read More

View Article and Full-Text PDF

Amplitude-Integrated EEG Monitoring in Pediatric Intensive Care: Prognostic Value in Meningitis before One Year of Age.

Children (Basel) 2022 May 5;9(5). Epub 2022 May 5.

Department of Neonatology, Reims University Hospital Alix de Champagne, 51100 Reims, France.

Pediatric morbidity from meningitis remains considerable. Preventing complications is a major challenge to improve neurological outcome. Seizures may reveal the meningitis itself or some complications of this disease. Read More

View Article and Full-Text PDF

[Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota].

Med Sci (Paris) 2022 May 24;38(5):416-418. Epub 2022 May 24.

Institut Pasteur, Université Paris Cité, Inserm U1117, Biology of Infection Unit, 75015 Paris, France - Institut Pasteur, Centre national de référence des Listeria et Centre collaborateur de l'OMS sur les Listeria 75015 Paris, France - Hôpital Necker-Enfants malades AP-HP, Service des maladies infectieuses et tropicales, Institut Imagine, 75015 Paris, France.

View Article and Full-Text PDF

CodY Is a Global Transcriptional Regulator Required for Virulence in Group B .

Front Microbiol 2022 28;13:881549. Epub 2022 Apr 28.

Department of Biology and Biotechnology "Lazzaro Spallanzani," University of Pavia, Pavia, Italy.

Group B (GBS) is a Gram-positive bacterium able to switch from a harmless commensal of healthy adults to a pathogen responsible for invasive infections in neonates. The signals and regulatory mechanisms governing this transition are still largely unknown. CodY is a highly conserved global transcriptional regulator that links nutrient availability to the regulation of major metabolic and virulence pathways in low-G+C Gram-positive bacteria. Read More

View Article and Full-Text PDF

Outpatient parenteral antimicrobial therapy: how young is too young?

Arch Dis Child 2022 May 10. Epub 2022 May 10.

General Medicine, The Royal Children's Hospital Melbourne, Parkville, Victoria, Australia.

Objective: To report the use, and assess the efficacy and outcomes of outpatient parenteral antimicrobial therapy (OPAT) in neonates (≤28 days of age), compared with older infants (1-12 months of age).

Design: A prospective 8-year observational study from September 2012 to September 2020.

Setting: The Hospital-in-the-Home (HITH) programme of the Royal Children's Hospital Melbourne. Read More

View Article and Full-Text PDF

Escherichia coli pathotype contamination in raw canine diets.

Am J Vet Res 2022 May 12;83(6). Epub 2022 May 12.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH.

Objective: To investigate the prevalence of Escherichia coli contamination and E coli virulence gene signatures consistent with known E coli pathotypes in commercially available conventional diets and raw-meat-based diets (RMBDs).

Sample: 40 diets in total (19 conventionally cooked kibble or canned diets and 21 RMBDs) obtained from retail stores or online distributors.

Procedures: Each diet was cultured for E coli contamination in 3 separate container locations using standard microbiological techniques. Read More

View Article and Full-Text PDF

Pearls & Oy-sters: Diagnosis and Subtyping of Listeria Ventriculitis in an Immunocompetent Host.

Neurology 2022 May 4. Epub 2022 May 4.

Department of Neurology, Kunming Medical University, Yunnan, China

is a gram-positive food-borne pathogen that causes gastrointestinal symptoms and central nervous system (CNS) infection in susceptible hosts.. Two lineages of cause the majority of neurolisteriosis in humans. Read More

View Article and Full-Text PDF

Dissemination of Gram-positive bacteria to the lung of newborn mice increases local IL-6 and TNFα levels in lethal bacteremia.

Microbes Infect 2022 Apr 29:104984. Epub 2022 Apr 29.

Departamento de Microbiología, Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Av. Francisco I. Madero, Mitras Centro, 64460, Monterrey, México. Electronic address:

Neonatal bacteremia remains the major cause of infectious diseases-related death, especially in preterm newborns. Gram-positive bacteria are the main causative agent of neonatal bacteremia and exhibit a high risk of causing pneumonia and/or meningitis. The pathogenesis of bacteremia in preterm newborn is poorly understood. Read More

View Article and Full-Text PDF

Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.

Lancet Glob Health 2022 06 28;10(6):e807-e819. Epub 2022 Apr 28.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UK.

Background: Group B streptococcus (GBS) colonisation during pregnancy can lead to invasive GBS disease (iGBS) in infants, including meningitis or sepsis, with a high mortality risk. Other outcomes include stillbirths, maternal infections, and prematurity. There are data gaps, notably regarding neurodevelopmental impairment (NDI), especially after iGBS sepsis, which have limited previous global estimates. Read More

View Article and Full-Text PDF

Associations of severe adverse perinatal outcomes among continuous birth weight percentiles on different birth weight charts: a secondary analysis of a cluster randomized trial.

BMC Pregnancy Childbirth 2022 Apr 30;22(1):375. Epub 2022 Apr 30.

Department of Midwifery Science, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, AVAG/Amsterdam Public Health, Amsterdam, Netherlands.

Objective: To identify neonatal risk for severe adverse perinatal outcomes across birth weight centiles in two Dutch and one international birth weight chart.

Background: Growth restricted newborns have not reached their intrinsic growth potential in utero and are at risk of perinatal morbidity and mortality. There is no golden standard for the confirmation of the diagnosis of fetal growth restriction after birth. Read More

View Article and Full-Text PDF

Measuring coverage and quality of supportive care for inpatient neonatal infections: EN-BIRTH multi-country validation study.

J Glob Health 2022 Apr 30;12:04029. Epub 2022 Apr 30.

London School of Hygiene & Tropical Medicine, London, UK.

Background: An estimated 7 million episodes of severe newborn infections occur annually worldwide, with half a million newborn deaths, most occurring in low- and middle-income countries. Whilst injectable antibiotics are necessary to treat the infection, supportive care is also crucial in ending preventable mortality and morbidity. This study uses multi-country data to assess gaps in coverage, quality, and documentation of supportive care, considering implications for measurement. Read More

View Article and Full-Text PDF

A nomogram for predicting paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis among HIV-infected individuals in China.

AIDS Res Ther 2022 04 26;19(1):20. Epub 2022 Apr 26.

Department of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital, Capital Medical University, 8 Jingshundong Street, Chaoyang District, Beijing, 100015, People's Republic of China.

Background: Cryptococcal meningitis (CM) associated immune reconstitution inflammatory syndrome (CM-IRIS) is the second most common complication in HIV-infected individuals with cryptococcal meningitis, with a reported mortality rate ranging from 8 to 30%. Given the devastating consequences of CM-IRIS related intracranial neuroinflammation and its challenging in diagnosis, we conducted a study to explore the risk factors and the occurrence of paradoxical CM-IRIS in HIV-infected patients, which is of great value for prevention and clinical management.

Methods: We conducted a retrospective cohort study to identify the indicators associated with paradoxical CM-IRIS among 86 HIV-infected patients with CM using univariate and multivariate cox analysis. Read More

View Article and Full-Text PDF

Rectovaginal Colonization with Serotypes of Group B with Reduced Penicillin Susceptibility among Pregnant Women in León, Nicaragua.

Pathogens 2022 Mar 29;11(4). Epub 2022 Mar 29.

Center of Infectious Diseases, Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University of Nicaragua, León 00068, Nicaragua.

Group B (GBS) are important causes of neonatal sepsis and meningitis globally. To elucidate the potential benefits of maternal GBS vaccines, data is needed on the epidemiology of maternal GBS rectovaginal colonization, distribution of serotypes, and resistance to intrapartum antibiotic prophylaxis (IAP). We collected rectal and vaginal samples from 305 pregnant women in León, Nicaragua between 35 and 40 weeks gestation. Read More

View Article and Full-Text PDF

Group B Streptococcal Colonization among Pregnant Women and Neonates in a Tertiary Care Hospital in South India.

Indian J Pediatr 2022 Apr 19. Epub 2022 Apr 19.

Department of Neonatology and Pediatrics, Renai Medicity, Kochi, Kerala, 682025, India.

Objectives: To assess the prevalence of maternal and neonatal group B Streptococcal colonization, incidence of neonatal systemic illness, and antibiotic sensitivity of isolates.

Methods: This prospective cohort study was conducted in a South Indian tertiary care hospital. Rectovaginal swabs from pregnant mothers at 36-37 wk gestation and throat and rectal swabs from their neonates at 48 h of age were collected. Read More

View Article and Full-Text PDF

Membrane Proteins and Proteomics of Cronobacter sakazakii Cells: Reliable Method for Identification and Subcellular Localization.

Appl Environ Microbiol 2022 05 18;88(9):e0250821. Epub 2022 Apr 18.

Department of Biochemistry and Microbiology, University of Chemistry and Technologygrid.448072.d, Prague, Czech Republic.

Members of the genus are responsible for severe infections in infants and immunosuppressed individuals. Although several virulence factors have been described, many proteins involved in the pathogenesis of such infections have not yet been mapped. This study is the first to fractionate Cronobacter sakazakii cells into outer membrane, inner membrane, periplasmic, and cytosolic fractions as the basis for improved proteome mapping. Read More

View Article and Full-Text PDF