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Gut Microbes 2022 Jan-Dec;14(1):2081474

Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Anti-SSA/Ro antibodies, while strongly linked to fetal cardiac injury and neonatal rash, can associate with a spectrum of disease in the mother, ranging from completely asymptomatic to overt Systemic Lupus Erythematosus (SLE) or Sjögren's Syndrome (SS). This study was initiated to test the hypothesis that the microbiome, influenced in part by genetics, contributes to disease state. The stool microbiome of healthy controls (HC) was compared to that of anti-SSA/Ro positive women whose children had neonatal lupus. Read More

Musculoskeletal Care 2022 May 26. Epub 2022 May 26.

Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain.

Background: Pregnancies in Systemic lupus erythematosus (SLE) are considered high risk and associated with maternal and obstetric complications.

Objectives: To determine the most important predictors for each of the main adverse pregnancy outcomes in SLE patients.

Methods: Patients with SLE were retrospectively analysed from 1990 to 2020. Read More

Indian J Pediatr 2022 Jul 17;89(7):734. Epub 2022 May 17.

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

J Rheumatol 2022 May 2. Epub 2022 May 2.

Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; Reference Center for Complex Congénital Cardiac Malformations - M3C, Necker-Enfants Malades Hospital, Université from Paris, Paris, France; Obstetrics and maternal-fetal unit / APHP Hôpital Necker-Enfant Malades, Université from Paris, Paris, France; Department of Internal Medicine, CHU Nantes, France; Rare Autoimmune and Systemic Diseases Competence Center, Reims, France; Pitié-Salpêtrière Hospital, Reference Center for Rare Autoimmune and Systemic Diseases, Paris, France; Timone Children's Hospital, Unité of Pediatric Resuscitation, Marseille, France; Tenon Hospital, Paris, France; CHU Fort de France, Martinique, France; Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Systemic Autoimmune Diseases in the North and North-West of France (CeRAINO) , U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France; Cardiopédiatrics, University Hospital of Nantes, France; Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; University Paris Descartes- Sorbonne Paris Cité, Paris, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. Address for correspondence: Nathalie Costedoat-Chalumeau, Hôpital Cochin, 75014, Paris, France. Fax number: +33158413246. Phone number: +33687508123

Objective: Transplacental passage of maternal anti-SSA and -SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB).

Methods: This retrospective study included anti-SSA/SSB antibody-positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter. Read More

Ann Rheum Dis 2022 Apr 25. Epub 2022 Apr 25.

Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

Objective: Neonatal lupus erythematosus (NLE) may develop after transplacental transfer of maternal autoantibodies with cardiac manifestations (congenital heart block, CHB) including atrioventricular block, atrial and ventricular arrhythmias, and cardiomyopathies. The association with anti-Ro/SSA antibodies is well established, but a recurrence rate of only 12%-16% despite persisting maternal autoantibodies suggests that additional factors are required for CHB development. Here, we identify fetal genetic variants conferring risk of CHB and elucidate their effects on cardiac function. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221077815

Neonatology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

Neonatal lupus is a rare entity, secondary to placental transfer of antibodies from mothers with immune-mediated conditions. While pulmonary involvement is common in lupus, its incidence in neonates is extremely rare, with very few cases being reported in the literature. The authors report a case of a neonate whose mother was diagnosed with systemic lupus erythematosus, with a prenatal diagnosis of third-degree atrioventricular block. Read More

Am J Dermatopathol 2022 Jul 6;44(7):519-522. Epub 2022 Apr 6.

Department of Dermatopathology, St George's University Hospital, London, United Kingdom.

Abstract: A case of lupus erythematosus tumidus (LET), a subtype of chronic cutaneous lupus erythematosus, in an 85-year-old woman who presented with discrete indurated erythematous plaques over the face and upper chest is described. A skin biopsy showed features in keeping with a diagnosis of LET. Unusually however, the lymphocytic infiltrate contained frequent macrophages that demonstrated hemophagocytosis. Read More

Cureus 2022 Feb 16;14(2):e22279. Epub 2022 Feb 16.

Pediatric Rheumatology, Valley Children's Healthcare, Madera, USA.

Neonatal lupus erythematosus (NLE) is a rare autoimmune entity observed in infants born to mothers with autoantibodies against Ro/SSA and La/SSB. Neonatal lupus may present with rash, heart block, hepatic dysfunction, and cytopenia. Although the condition is usually self-limited, serious sequelae can occur. Read More

Int J Womens Health 2022 15;14:199-211. Epub 2022 Feb 15.

Division of Rheumatic Diseases, UTSouthwestern Medical Center, Dallas, TX, USA.

Systemic lupus erythematosus (SLE) affects reproductive aged women. Issues regarding family planning are an important part of SLE patient care. Women with SLE can flare during pregnancy, in particular those who have active disease at conception or prior history of renal disease. Read More

Clin Dermatol 2022 Feb 3. Epub 2022 Feb 3.

Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address:

Annular skin lesions have a unique morphology, and the dramatic appearance of these skin eruptions in infants can cause concern for parents and clinicians. Annular lesions appearing during infancy (defined here as birth to 1 year of age) lend to a broad differential, ranging from benign cutaneous disorders to severe systemic diseases. This review summarizes the pathogenesis, clinical and histopathologic findings, and management options of possible etiologies for annular skin lesions in infants, including annular erythema of infancy, neonatal lupus erythematosus, dermatophyte infections, hemorrhagic edema of infancy, and urticaria multiforme. Read More

Clin Rev Allergy Immunol 2022 Jan 18. Epub 2022 Jan 18.

Department of Oral Biology, University of Florida, 1395 Center Drive, Gainesville, FL, 32610-0424, USA.

This review highlights the 30 plus years research progress since the discovery of autoantibody to Ro52/TRIM21 in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SjS). After the initial expression cloning of the Ro52 cDNA, it has taken many years to the current understanding in the interesting biological function of Ro52 as an E3 ubiquitin ligase and its role in innate immune clearance of intracellular IgG-bound complex. Early observations show that anti-Ro52, mostly associated with anti-SS-A/Ro60 and/or anti-SS-B/La, is commonly found in SLE (40-70%), SjS (70-90%), neonatal lupus erythematosus (NLE, 75-90%), and subacute cutaneous lupus erythematosus (50-60%). Read More

Clin Dermatol 2021 Dec 31. Epub 2021 Dec 31.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida, USA.

Annular lichenoid diseases encompass a diverse range of pathologies that present as circular, raised, or flat lesions that may vary in size and number. Examples include annular lichenoid dermatitis of youth, annular lichen planus, erythema dyschromicum perstans, erythema multiforme, fixed drug eruption, lichen sclerosus, neonatal lupus, porokeratosis, subacute cutaneous lupus erythematosus, and lichenoid syphilis. Clinical morphology and histopathology can differentiate these entities. Read More

Lupus 2022 Jan 2;31(1):77-88. Epub 2022 Jan 2.

Department of Obstetrics and Gynaecology, Faculty of Medicine Siriraj Hospital, 65106Mahidol University, Bangkok, Thailand.

Objectives: To identify the prenatal predisposing factors related to neonatal lupus erythematosus (NLE).

Materials And Methods: A retrospective case-control study was made of 131 pregnant women with positive anti-Ro or anti-La autoantibodies and known neonatal outcomes between January 2002 and December 2019 at Siriraj Hospital, Bangkok, Thailand. There were 101 unaffected neonates and 30 NLE cases confirmed postnatally. Read More

Lupus 2021 Dec 7;30(14):2310-2317. Epub 2021 Dec 7.

Facultad de Ciencias de la Salud, 28012Universidad Icesi, Cali, Colombia.

Objective: Pregnant women with SLE have higher probabilities of maternal complications. SLE during pregnancy has alternating patterns of remission and flare-ups; however, most pregnant SLE patients tend to worsen with associated poor obstetric and perinatal outcomes. This study aimed to describe obstetric outcomes in pregnant women with SLE. Read More

J Pediatr 2022 Mar 3;242:258-259. Epub 2021 Dec 3.

Department of Neonatology, Cork University Maternity Hospital, Wilton, Cork, Ireland.

BMJ Case Rep 2021 Nov 29;14(11). Epub 2021 Nov 29.

Paediatrics, Hospital Garcia de Orta EPE, Almada, Setúbal, Portugal.

Neonatal lupus is an uncommon entity. The main manifestations are cutaneous and cardiac. It is caused by transplacental passage of maternal antibodies (anti-Ro/SSA or anti-La/SSB), and the diagnosis is made by its detection in the mother or child. Read More

BMJ Case Rep 2021 Nov 16;14(11). Epub 2021 Nov 16.

Neonatal Intensive Care Unit, Calmette Hospital, Phnom Penh, Cambodia.

The most common cause of congenital heart block (CHB) is neonatal lupus, an acquired autoimmune disease caused by transplacental transfer of maternal antibodies to the fetus. A full-term female neonate was admitted to neonatal intensive care unit for severe bradycardia with stable haemodynamics. The mother, showing no clinical symptoms or any particular history, was transferred to our tertiary centre for profound fetal bradycardia. Read More

Clin J Am Soc Nephrol 2022 01 3;17(1):65-74. Epub 2021 Nov 3.

Pediatric Nephrology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background And Objectives: Performing adequately powered clinical trials in pediatric diseases, such as SLE, is challenging. Improved recruitment strategies are needed for identifying patients.

Design, Setting, Participants, & Measurements: Electronic health record algorithms were developed and tested to identify children with SLE both with and without lupus nephritis. Read More

Lupus 2021 Nov 24;30(13):2165-2175. Epub 2021 Oct 24.

Maternal Fetal Unit, 522166Centro Hospitalar Universitário do Porto, Centro Materno Infantil do Norte, Oporto, Portugal.

Objective: Systemic lupus erythematosus (SLE) is a life-threatening disorder that affects women at reproductive age. We evaluate the clinical impact of pregnancy in a cohort of Portuguese SLE patients and the risk factors associated with maternal and fetal adverse outcomes.

Methods: A retrospective observational study that included all pregnant women with SLE managed at a Portuguese tertiary hospital, between January 1993 and December 2019. Read More

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, 02-637 Warsaw, Poland.

Neonatal lupus erythematosus (NLE) is a syndrome of clinical symptoms observed in neonates born to mothers with antibodies to soluble antigens of the cell nucleus. The main factors contributing to the pathogenesis of this disease are anti-Sjögren Syndrome A (anti-SS-A) antibodies, known as anti-Ro, and anti-Sjögren Syndrome B (anti-SS-B) antibodies, known as anti-La. Recent publications have also shown the significant role of anti-ribonucleoprotein antibodies (anti-RNP). Read More

J Trop Pediatr 2021 07;67(3)

Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand.

Objectives: The purpose of the study was to determine the clinical features of NLE and to compare the neonatal outcomes between newborns born to pregnant women with SLE and healthy pregnant women.

Methods: We conducted a retrospective cohort analysis between 2007 and 2019 in a tertiary referral hospital in Thailand. A total of 118 pregnant women with SLE with 132 neonates compared with 264 randomly selected healthy pregnant women. Read More

Dermatol Ther 2021 09 15;34(5):e15078. Epub 2021 Aug 15.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Although tinea capitis is common in children, but it is rare in newborns. It should be differentiated with neonatal lupus erythematosus, nummular eczema, psoriasis, seborrheic dermatitis, erythema annular centrifugum, annular urticaria, and annular erythema of infancy. Tinea capitis usually needs oral antifungal therapy, but the data of use in newborn is limited. Read More

Eur J Dermatol 2021 Jun;31(3):432-433

Department of Dermatovenereology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.

J Clin Med 2021 Jul 20;10(14). Epub 2021 Jul 20.

Department of Pediatrics, Seoul National University Children's Hospital & College of Medicine, Seoul 03080, Korea.

Neonatal lupus erythematosus (NLE) is a rare disease caused by passively transmitted autoantibodies from the mother. NLE is a multi-organ system disease characterized by cutaneous, cardiac, hematological, hepatobiliary, and neurological manifestations. This study aimed to review the various symptoms and clinical manifestations in young infants with NLE and their mothers. Read More

Pediatr Dermatol 2021 Nov 11;38 Suppl 2:135-136. Epub 2021 Jul 11.

Department of Dermatology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.

Neonatal lupus erythematosus (NLE) is an autoimmune disease characterized by a periorbital erythematous rash. Although post-inflammatory hypopigmentation and telangiectasias are known possible sequelae, these features may be particularly noticeable in skin of color. Herein, we describe two infants with skin of color in whom periorbital hypopigmentation and telangiectasias were clues to the diagnosis of NLE. Read More

Sultan Qaboos Univ Med J 2021 May 21;21(2):e244-e252. Epub 2021 Jun 21.

Department of Medicine, Sultan Qaboos University, Muscat, Oman.

Objectives: This study was conducted to assess pregnancy outcomes in women with systemic lupus erythematosus (SLE) in Oman.

Methods: A retrospective cohort study of 149 pregnancies in 98 women with SLE was conducted over 10 years to evaluate the impact of clinical and laboratory parameters in predicting adverse pregnancy outcomes.

Results: Mean maternal age was 30. Read More

CMAJ 2021 05;193(22):E805

Dermatology (Coulombe) and Rheumatology (Barsalou), Department of Pediatrics, CHU Ste-Justine, Université de Montréal, Montréal, Que.

Neonatology 2021 25;118(3):368-372. Epub 2021 May 25.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

A 31-day-old infant was admitted to the pediatric intensive care unit due to shock and anemia. The mother had systemic lupus erythematosus and direct antiglobulin test (DAT)-positive hemolytic anemia. The perinatal course of this infant and the mother was uneventful. Read More

Clin Exp Rheumatol 2021 Nov-Dec;39(6):1446. Epub 2021 May 5.

UOC Dermatologia, IRCCS Istituto Giannina Gaslini, Genova, Italy.

J Rheumatol 2021 09 1;48(9):1417-1421. Epub 2021 Apr 1.

L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Genetics and Genome Biology, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluate the association between ethnicity and neonatal lupus erythematosus (NLE), as well as specific NLE manifestations in a large multiethnic population.

Methods: We conducted a cohort study of the children (≤ 1 yr of age) seen in the NLE clinic at The Hospital for Sick Children (SickKids), between January 2011 and April 2019. The cohort was divided into European, non-European, and mixed European-non-European groups according to parent-reported child's ethnicity (Canada Census categories). Read More