J Rheumatol 2022 May 2. Epub 2022 May 2.
Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; Reference Center for Complex Congénital Cardiac Malformations - M3C, Necker-Enfants Malades Hospital, Université from Paris, Paris, France; Obstetrics and maternal-fetal unit / APHP Hôpital Necker-Enfant Malades, Université from Paris, Paris, France; Department of Internal Medicine, CHU Nantes, France; Rare Autoimmune and Systemic Diseases Competence Center, Reims, France; Pitié-Salpêtrière Hospital, Reference Center for Rare Autoimmune and Systemic Diseases, Paris, France; Timone Children's Hospital, Unité of Pediatric Resuscitation, Marseille, France; Tenon Hospital, Paris, France; CHU Fort de France, Martinique, France; Univ. Lille, Inserm, CHU Lille, Department of Internal Medicine and Clinical Immunology, Reference Center for Rare Systemic Autoimmune Diseases in the North and North-West of France (CeRAINO) , U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France; Cardiopédiatrics, University Hospital of Nantes, France; Cochin Hospital, Ile de France Rare Autoimmune and Systemic Diseases Reference Center, Paris, France; University Paris Descartes- Sorbonne Paris Cité, Paris, France; INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. Address for correspondence: Nathalie Costedoat-Chalumeau, Hôpital Cochin, 75014, Paris, France. Fax number: +33158413246. Phone number: +33687508123
Objective: Transplacental passage of maternal anti-SSA and -SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB).
Methods: This retrospective study included anti-SSA/SSB antibody-positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter. Read More