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    641 results match your criteria Neonatal Lupus Erythematosus

    1 OF 13

    Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.
    Autoimmun Rev 2017 Feb 14. Epub 2017 Feb 14.
    Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
    Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur. Read More

    Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.
    Immunol Res 2017 Jan 30. Epub 2017 Jan 30.
    Obstetric and Gynecology Department, High Risk Pregnancy Unit, Autoimmune diseases and pregnancy clinic, University Hospital La Paz, Paseo de la Castella 261, 28046, Madrid, Spain.
    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). Read More

    [Down syndrome and heart block secondary to neonatal lupus].
    Rev Med Inst Mex Seguro Soc 2017 Jan-Feb;55(1):128-132
    Departamento de Cardiología Pediátrica, Hospital General Regional 36, Instituto Mexicano del Seguro Social, Puebla, Puebla, México.
    In Down syndrome, so far, has not been reported it's association with congenital heart block, this entity is rare and occurred in only 1% of mothers who have systemic lupus erythematosus, the presence of anti-Ro antibodies cross the placenta presenting neonatal lupus with skin lesions and congenital heart block, bradycardia, which is why we describe the following case. This is a new male end product of asymptomatic young mother, but serological birth with stigmata of Down syndrome, birth presents congenital bradycardia rare manifestation abnormalities, but common in children of mothers with lupus are initiated study protocol, realizing you including laboratory tests and immunological studies cabinet as electrocardiogram and echocardiogram, which gave tone to take the mother immunological studies, being positive antiRo. We concluded that the risk of heart block in a patient with Down syndrome is the same as for the general population. Read More

    Neonatal lupus erythematosus with congenital heart block in twins.
    Tunis Med 2016 Jul;94(7):401-404
    Background - Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by transplacental passage of maternal antibodies SSA/Ro, SSB/La or U1 ribonucleoproteins. The most common clinical manifestations are skin rash, cardiac lesions, thrombocytopenia, anemia and hepatosplenomegaly. Complete congenital heart block is usually irreversible needing a pacemaker implantation in two-thirds of cases. Read More

    Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings.
    Turk J Pediatr 2016 ;58(1):106-108
    Marmara University School of Medicine Department of Dermatology, İstanbul, Turkey.
    Neonatal lupus erythematosus is an autoimmune disorder mainly affecting the heart and skin. It is the most common cause of congenital heart block. In addition, hematological, hepatobiliary and neurological involvement may occur. Read More

    [Clinical features and adverse pregnancy outcomes of new onset systemic lupus erythematosus during pregnancy].
    Zhonghua Yi Xue Za Zhi 2016 Nov;96(41):3300-3304
    Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    Objective: To investigate the clinical characteristics and adverse pregnancy outcomes in pregnant women with new onset systemic lupus erythematosus (SLE) during pregnancy. Methods: The clinical data of 263 pregnancies with SLE in the First Affiliated Hospital of Zhongshan University from 2001 to 2015 were collected and analyzed retrospectively. Results: Of all the 263 pregnancies, 188 were diagnosed before pregnancy and 75 were newly diagnosed during pregnancy. Read More

    A comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus.
    J Autoimmun 2016 Nov 2;74:106-117. Epub 2016 Jul 2.
    Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address:
    Nowadays, most of the young women affected by Systemic Lupus Erythematosus (SLE) can carry out one or more pregnancies thanks to the improvement in treatment and the consequent reduction in morbidity and mortality. Pregnancy outcome in these women has also greatly improved in the last decades. A correct timing for pregnancy (tailored on disease activity and established during a preconception counselling), together with a tight monitoring during the three trimesters and the post-partum period (to timely identify and treat possible obstetric complications or maternal disease flares), as well as the concept of multidisciplinary management, are currently milestones of the management of pregnancy in SLE patients. Read More

    Management of Pregnancy in Lupus Patients.
    J Assoc Physicians India 2016 Aug;64(8):62-66
    Assistant Professor, Department of Surgery, MG Medical College, Jaipur, Rajasthan.
    Systemic lupus erythematosus (SLE) mostly affects young women of reproductive age group. SLE patients may conceive as any normal woman but complication may occur in these patients if the disease is active. Pregnancy in SLE may lead to 1. Read More

    Management of Systemic Lupus Erythematosus During Pregnancy.
    Annu Rev Med 2017 Jan 21;68:271-285. Epub 2016 Sep 21.
    Hospital for Special Surgery, Weill Cornell Medicine, New York, NY 10021; email:
    Reproductive issues including contraception, fertility, and pregnancy are important components of the comprehensive care of women with systemic lupus erythematosus (SLE). SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. Pre-pregnancy assessment is important to identify patients with severe disease-related damage who should avoid pregnancy, counsel patients to conceive when disease has been stable and inactive on appropriate medications, and assess relevant risk factors including renal disease, antiphospholipid antibody, and anti-Ro/SS-A and anti-La/SS-B antibodies. Read More

    Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block.
    J Obstet Gynaecol India 2016 Oct 17;66(Suppl 1):112-6. Epub 2015 Dec 17.
    Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, 411040 India.
    Background: Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was conducted to know the incidence of fetal CHB in patients of SLE who had ANA, anti-Ro/SSA and anti-La/SSB positivity. Read More

    Outcome of pregnancy in patients with systemic lupus erythematosis at Korle-bu Teaching Hospital.
    Ghana Med J 2016 Jun;50(2):72-7
    Department of Medicine and Therapeutics, Korle-bu Teaching Hospital, P.O. Box KB 77 Accra, Ghana; School of Medicine and Dentistry, College of Health Sciences, University of Ghana P.O. Box GP 4236, Accra.
    Objective: To study maternal and fetal outcomes in Ghanaian women with systemic lupus erythematosus (SLE).

    Methods: Retrospective study of pregnancies in women with SLE in a single centre in Ghana.

    Results: The mean age was 30. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Warm antibody hemolytic anemia-a rare presentation of neonatal lupus.
    Lupus 2016 Aug 11. Epub 2016 Aug 11.
    Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
    Neonatal lupus erythematosus (NLE) affects 1%-2% pregnant females with autoimmunity. An infant presented with steroid refractory hemolytic anemia as a manifestation of NLE. A trial of withholding breastfeeding had a transient response, but infant was eventually put on cyclosporin therapy to control the hemolysis. Read More

    Long-Term Follow-Up of Children with Heart Block Born from Mothers with Systemic Lupus Erythematosus: A Retrospective Study from the Database Pediatric and Congenital Heart Disease in University Hospitals Leuven.
    Pacing Clin Electrophysiol 2016 Sep 2;39(9):935-43. Epub 2016 Aug 2.
    Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
    Background: Children from mothers with systemic lupus erythematosus are frequently born with congenital heart block. This study aimed at evaluating long-term outcome because long-term data are scarce.

    Methods: In the database of pediatric and congenital heart disease (University Hospitals Leuven), 19 children from systemic lupus erythematosus mothers and who were born with or developed atrioventricular block were identified. Read More

    Fetal Monitoring of Patients Diagnosed with Systemic Lupus Erythematosus - A Case Report.
    Z Geburtshilfe Neonatol 2016 Aug 13;220(4):179-82. Epub 2016 Jun 13.
    Departement of Obstetrics & Gynecology, Philipps University of Marburg, Marburg, Germany.
    We report a case of pathological foetal Doppler velocity, specifically the absence of end diastolic flow in the umbilical artery (AEDV/REDV), suspected diabetic pregnancy and mesangioproliferative glomerulonephritis, at 32 weeks of gestation. The foetal heart rate tracings were evaluated using a computerised cardiotocogram (Oxford Sonicaid system 8002 Chichester, England) 1 for 20-30 min parallel to the routine cardiotocogram. The ultrasound control at 33 weeks of gestation showed oligohydramnion, foetal centralisation and reduced interval foetal growth. Read More

    Unusual Skin Manifestations in Neonatal Lupus Erythematosus.
    J Med Assoc Thai 2015 Nov;98 Suppl 10:S147-9
    Neonatal lupus erythematous (NLE) is a rare autoimmune disease caused by placental transfer of maternal anti-SSA/Ro or anti-SSB/La antibodies. It usually presents with transient cutaneous lesions, congenital heart block and other systemic symptoms. The authors report a case of neonatal lupus erythematosus who presented with targetoid-like lesions on both feet. Read More

    Pregnancy and contraception in systemic and cutaneous lupus erythematosus.
    Ann Dermatol Venereol 2016 Oct 26;143(10):590-600. Epub 2016 Apr 26.
    Department of internal medicine, medical center, reference center for rare systemic and autoimmune diseases, hôpital Cochin, AP-HP, université René-Descartes, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address:
    A causal link has long been described between estrogen and systemic lupus erythematosus activity. Contraceptive and pregnancy management is now common for lupus patients, but pregnancy continues to be associated with higher maternal and fetal mortality/morbidity in systemic lupus erythematosus patients than among the general population. Potential complications include lupus flares, obstetric complications (fetal loss, in utero growth retardation, premature birth) and neonatal lupus syndrome. Read More

    A 10-year retrospective study of neonatal lupus erythematous in China.
    Asian Pac J Allergy Immunol 2016 Jun;34(2):174-8
    Griffith Health Institute - Griffith University, Gold Coast, QLD, Australia.
    Background: Neonatal lupus erythematosus (NLE) is not a common disease. The death rate of complete congenital heart block (CCHB), which is the most severe clinical manifestation, is as high as 20% to 30%, so early recognition of infants at risk is important.

    Objectives: To investigate the clinical features and long-term prognosis of NLE. Read More

    Cutaneous Lupus Erythematosus in Children: Experience from a Tertiary Care Pediatric Dermatology Clinic.
    Pediatr Dermatol 2016 Mar-Apr;33(2):200-8
    As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait City, Kuwait.
    Background/objectives: The manifestations of cutaneous lupus erythematosus (CLE) and their relevance to systemic disease are well characterized in adults, but data are limited in children. The objective of the current study was to examine the spectrum of CLE and its relationship to systemic disease in children from a tertiary care pediatric dermatology clinic.

    Materials And Methods: An analysis of 26 children with CLE registered consecutively over 14 years was performed. Read More

    A case of neonatal lupus erythematosus in a very low-birth-weight infant that suffered intraventricular hemorrhage at birth.
    Mod Rheumatol 2016 Jun 2:1-3. Epub 2016 Jun 2.
    b Department of Pediatrics , Akita University Graduate School of Medicine , Akita , Japan , and.
    This report describes the case of a very low-birth-weight male infant with neonatal lupus erythematosus. His mother had Sjögren's syndrome, and her previous child had suffered a complete heart block. Accordingly, maternal steroid (betamethasone) therapy was administered to prevent a congenital heart block for 15 weeks (from 13 to 27 weeks' gestation). Read More

    Neonatal lupus erythematosus: a cutaneous cases based update.
    Ital J Pediatr 2016 Jan 7;42. Epub 2016 Jan 7.
    Department of Surgery, Dermatology Unit, Regina Margherita Children's Hospital, University of Turin, Turin, Italy.
    Background: Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.

    Case Presentation: Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. Read More

    Cytokine profile in two siblings with neonatal lupus erythematosus.
    Pediatr Int 2015 Dec;57(6):1211-4
    Department of Maternal, Fetal and Neonatal Medicine, University of Tokyo Hospital, Tokyo, Japan.
    We studied the cytokine profile of two siblings with neonatal lupus erythematosus (NLE) born to a mother positive for serum anti-Ro and -La antibodies, who did not receive any medication during the two pregnancies. The first sibling was found to have complete atrioventricular block in utero and became severely ill after birth. He fulfilled the diagnostic criteria for hemophagocytic lymphohistiocytosis on day 2. Read More

    Endosomal Toll-like receptors in clinically overt and silent autoimmunity.
    Immunol Rev 2016 Jan;269(1):76-84
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, USA.
    Toll-like receptors (TLRs), first identified as pattern recognition receptors, are now recognized to serve as a key interface between innate and adaptive immunity. Systemic lupus erythematosus (SLE) is characterized by both continuous and cyclic stimulation of the innate and adaptive immune system by endogenous nucleic acids released from apoptotic or necrotic cells. TLR7 and TLR9 function as innate sensors of viral infection as their ligands are ssRNA and dsDNA, respectively. Read More

    Treatment of Congenital Complete Atrioventricular Heart Block With Permanent Epicardial Pacemaker in Neonatal Lupus Syndrome.
    Iran Red Crescent Med J 2015 Sep 1;17(9):e16200. Epub 2015 Sep 1.
    Department of Pediatrics, Ege University, Faculty of Medicine, Division of Neonatology, Izmir, Turkey.
    Introduction: Neonatal lupus syndrome (NLS) is a passively acquired autoimmune condition due to the transplacental passage of maternal anti-Ro/SSA and anti-La/SSB antibodies in mothers with systemic lupus erythematosus (SLE), and congenital complete heart block (CHB) is its most serious manifestation. Skin and hepatic involvement may occur in later infancy.

    Case Presentation: A term infant with fetal bradycardia, detected at the 23rd gestational age, was diagnosed with CHB due to NLS and was successfully treated with a permanent epicardial pacemaker. Read More

    Maternal predictive factors for fetal congenital heart block in pregnant mothers positive for anti-SS-A antibodies.
    Mod Rheumatol 2016 Jul 20;26(4):569-75. Epub 2015 Nov 20.
    l Department of Maternal Medicine , National Center for Child Health and Development , Tokyo , Japan , and.
    Objective: To determine the maternal predictive factors for fetal congenital heart block (CHB) in pregnancy in mothers positive for anti-SS-A antibodies.

    Methods: The Research Team for Surveillance of Autoantibody-Exposed Fetuses and Treatment of Neonatal Lupus Erythematosus, the Research Program of the Japan Ministry of Health, Labor and Welfare, performed a national survey on pregnancy of mothers positive for anti-SS-A antibodies. We analyzed 635 pregnant mothers who tested positive for anti-SS-A antibodies before conception but had no previous history of fetal CHB. Read More

    Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years--a retrospective cohort study.
    Clin Rheumatol 2015 Oct 26;34(10):1721-8. Epub 2015 Aug 26.
    Department of Rheumatology, Peking Union Medical College Hospital, No. 41 Damucang Hutong, Beijing, China.
    The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated retrospectively, and the newborns were followed up as a cohort in 3 months. χ (2) test or logistic regression was used to predict the risk factors of lupus flares during pregnancy, fetal loss, and NLE. Read More

    Pregnancy-Related Challenges in Systemic Autoimmune Diseases.
    J Infus Nurs 2015 Sep-Oct;38(5):360-8
    Spedali Civili di Brescia, Brescia, Italy (Dr Taraborelli); University of Brescia, Brescia, Italy (Dr Taraborelli); University of Pavia, Pavia, Italy (Dr Taraborelli); Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, New York, New York (Drs Erkan and Taraborelli); Weill Medical College, Cornell University, New York, New York (Dr Erkan). Mara Taraborelli, MD, is a rheumatology fellow at the Spedali Civili di Brescia and the University of Brescia in Italy. She is also affiliated with the University of Pavia in Italy and the Hosptial for Special Surgery in New York City. Doruk Erkan, MD, MPH, is an associate physician-scientist at the Barbara Volcker Center for Women and Rheumatic Diseases and an associate attending physician at the Hospital for Special Surgery in New York City, where he is also an associate professor of medicine at Weill Medical College of Cornell University.
    The awareness of pregnancy-related physiologic changes and complications is critical for the appropriate assessment and management of pregnant patients with systemic autoimmune diseases. The overlapping features of physiologic and pathological changes, selected autoantibodies, and the use of potentially teratogenic medications can complicate their management during pregnancy. While pregnancy in lupus patients presents an additional risk to an already complex situation, in patients with no disease activity, the risk of a future pregnancy-related complication is relatively low. Read More

    Serum Biomarkers of Inflammation, Fibrosis, and Cardiac Function in Facilitating Diagnosis, Prognosis, and Treatment of Anti-SSA/Ro-Associated Cardiac Neonatal Lupus.
    J Am Coll Cardiol 2015 Aug;66(8):930-9
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, New York.
    Background: Cardiac manifestations of neonatal lupus (cardiac NL) include congenital heart block and cardiomyopathy. Several candidate biomarkers were evaluated in cases at risk for cardiac NL on the basis of potential roles in inflammation, fibrosis, and cardiac dysfunction: C-reactive protein (CRP); NT-pro-B-type natriuretic peptide (NT-proBNP); troponin I; matrix metalloproteinase (MMP)-2; urokinase plasminogen activator (uPA); urokinase plasminogen activator receptor (uPAR); plasminogen; and vitamin D.

    Objectives: Identification of maternal and fetal biomarkers associated with development and morbidity of cardiac NL should provide clues to pathogenesis with translational implications for management. Read More

    Description of 214 cases of autoimmune congenital heart block: Results of the French neonatal lupus syndrome.
    Autoimmun Rev 2015 Dec 15;14(12):1154-60. Epub 2015 Aug 15.
    AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France; Université Paris Descartes-Sorbonne Paris Cité, Paris, France. Electronic address:
    Background: Cardiac neonatal lupus syndrome is due to anti-SSA or SSB antibodies and mainly includes congenital heart block (CHB) and dilated cardiomyopathy (DCM). Its optimal management is still debated. We report a large series of autoimmune high degree CHB. Read More

    Histiocytoid neutrophilic dermatitis, an unusual histopathology in neonatal lupus erythematosus.
    J Cutan Pathol 2015 Aug 13. Epub 2015 Aug 13.
    Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    The authors reported histiocytoid neutrophilic dermatitis in neonatal lupus erythematosus (NLE). One-month-old male infant presented with annular erythematous plaques at the face and trunk. Serologic studies revealed positive anti-ribonuclear protein antibodies (RNP) and antinuclear antibodies (ANA). Read More

    Epigenetics and Systemic Lupus Erythematosus: Unmet Needs.
    Clin Rev Allergy Immunol 2016 Jun;50(3):367-76
    Division of Rheumatology, Istituto G. Pini, Piazza C. Ferrari, 1, 20122, Milan, Italy.
    Systemic lupus erythematosus (SLE) is a chronic relapsing-remitting autoimmune disease affecting several organs. Although the management of lupus patients has improved in the last years, several aspects still remain challenging. More sensitive and specific biomarkers for an early diagnosis as well as for monitoring disease activity and tissue damage are needed. Read More

    Recurrence of Neonatal Lupus Post-Cord Blood Transplant for Severe Congenital Neutropenia.
    Pediatrics 2015 Aug 20;136(2):e535-8. Epub 2015 Jul 20.
    University of Michigan Medical School, Ann Arbor, Michigan; and Division of Pediatric Hematology/Oncology, University of Michigan, Ann Arbor, Michigan.
    Neonatal lupus erythematosus (NLE) is a rare autoimmune disorder associated with transplacental migration of maternal autoantibodies against SS-A (Ro) or SS-B (La) antigens that results in cardiac, hepatic, cutaneous, and hematologic manifestations. Although NLE-associated neutropenia is considered transient and benign, neutropenia caused by severe congenital neutropenia (SCN) is life-threatening. Diagnosing a complicated picture of neonatal neutropenia can be challenging because there are many overlapping features between the acquired and inherited etiologies. Read More

    Neonatal lupus erythematosus: a review of 123 cases in China.
    Int J Rheum Dis 2015 Sep 14;18(7):761-7. Epub 2015 Jul 14.
    Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China.
    Aim: To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus (NLE) in China.

    Method: We reviewed 12 NLE cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang. Read More

    Rheumatologic emergencies.
    Clin Rheumatol 2015 Dec 24;34(12):2011-9. Epub 2015 Jun 24.
    Rheumatology Department, Hospital Universitario de Caracas, HUC-UCV, Caracas, 1020, DC, Venezuela.
    Rheumatological conditions can sometimes present as emergencies. These can occur due to the disease process or infection; contrary to what many people think, rheumatologic emergencies like a pain, rheumatic crisis, or attack gout do not compromise the patient's life. This article mentioned only true emergencies: catastrophic antiphospholipid syndrome (cAPS), kidney-lung syndrome, central nervous system (CNS) vasculitis, anti-Ro syndrome (neonatal lupus), and macrophage activation syndrome (MAS). Read More

    Pregnancy Associated with Systemic Lupus Erythematosus: Immune Tolerance in Pregnancy and Its Deficiency in Systemic Lupus Erythematosus--An Immunological Dilemma.
    J Immunol Res 2015 18;2015:241547. Epub 2015 May 18.
    Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "V. Babes" Timisoara, Emergency County Clinical Hospital Timisoara, Romania.
    Pregnancy is a physiological condition that requires immune tolerance to the product of conception. Systemic lupus erythematosus (SLE) is a disease with well-represented immune mechanisms that disturb immune tolerance. The association of pregnancy with systemic lupus erythematosus creates a particular immune environment in which the immune tolerance specific of pregnancy is required to coexist with alterations of the immune system caused by SLE. Read More

    Maternal and foetal outcomes in pregnant systemic lupus erythematosus patients: an incident cohort from a stable referral population followed during 1990-2010.
    Scand J Rheumatol 2015 19;44(5):377-84. Epub 2015 Jun 19.
    a Departments of Rheumatology , Aarhus University Hospital , Aarhus , Denmark.
    Objectives: To assess the impact of systemic lupus erythematosus (SLE) on pregnancy outcome in a cohort of incident pregnant lupus patients referred to a Danish university hospital during 1990-2010.

    Method: All pregnant lupus patients were referred to the university hospital from a stable referral area with approximately 1.4 million inhabitants. Read More

    Neonatal Lupus erythematosus Following Rheumatoid Arthritis: Case Report and Literature Review.
    Iran J Pediatr 2014 Aug 16;24(4):445-8. Epub 2014 May 16.
    Department of Ophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Neonatal lupus erythematosus (NLE) is a transient autoimmune disease of developing fetus and neonate in mothers with systemic lupus erythematosus (SLE). In this report we introduce an infant with NLE whose mother had rheumatoid arthritis.

    Case Presentation: Our case was a 40 day old male infant with discoid-like and annular skin lesions over forehead and neck, irritability and low grade fever. Read More

    Congenital lupus with multiorgan involvement: a case report and review of literature.
    Pediatr Dermatol 2015 May-Jun;32(3):401-4. Epub 2015 Feb 7.
    Department of Radiology, Hospital Costa del Sol, Marbella, Málaga, Spain.
    Neonatal lupus erythematosus (NLE) is an autoimmune disease caused by transplacental antibodies that can damage fetal tissue and cause various findings. With the exception of congenital heart block, which can be easily recognized at birth because of neonatal cardiac monitoring during the delivery and immediately after birth, most cases of NLE are recognized within days to weeks of life, but fewer than 10 cases with findings present at birth have been reported. We report the case of a newborn with extensive cutaneous eruption at the time of birth and multisystemic involvement, including hematologic, respiratory, hepatic, and neurologic involvement. Read More

    Seeing double: annular diaper rash in twins.
    Pediatr Dermatol 2015 May-Jun;32(3):410-3. Epub 2015 Jan 30.
    Cooper Medical School of Rowan University, Camden, New Jersey.
    We report a case of dichorionic, diamniotic twins who developed similar erythematous, annular, erosive plaques in the inguinal folds in the first few weeks of life that were refractory to topical antifungals and oral antibiotics. The twins were found to have high transaminase levels, antinuclear antibody positivity, and anti-SSS/Ro) and anti-SSB/La autoantibodies. The rash resolved without scarring by 7 months of age with the use of low-potency topical corticosteroids. Read More

    Macrophage activation syndrome in a newborn infant born to a mother with autoimmune disease.
    J Perinatol 2015 Feb;35(2):158-60
    Department of Pediatrics, College of Medicine, The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Republic of Korea.
    Macrophage activation syndrome (MAS) is a complication of rheumatic disorders characterized by cytopenia, multiple organ dysfunction and coagulopathy associated with an inappropriate activation of macrophage. In neonatal lupus erythematosus, MAS is rare but fatal, requiring early diagnosis and treatment for optimal outcome. We report a case of MAS in a neonate born to a mother with autoimmune disease, improved by treatment with steroid, intravenous immunoglobulin and cyclosporine. Read More

    [Systemic lupus erythematosus and antiphospholipid syndrome: How to manage pregnancy?].
    Rev Med Interne 2015 Mar 8;36(3):173-81. Epub 2015 Jan 8.
    Service de médecine interne, pôle médecine, centre de référence maladies auto-immunes et systémiques rares, hôpital Cochin, université Paris Descartes, AP-HP, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14, France. Electronic address:
    Pregnancy in systemic lupus erythematosus patients is a common situation that remains associated with higher maternal and fetal mortality/morbidity than in the general population. Complications include lupus flares, obstetrical complications (fetal loss, in utero growth retardation, prematurity) and neonatal lupus syndrome. The association with antiphospholipid antibodies or antiphospholipid syndrome increases the risk of obstetrical complications. Read More

    Isolated anti-Ro/SSA thrombocytopenia: a rare feature of neonatal lupus.
    Pan Afr Med J 2015 27;22:312. Epub 2015 Nov 27.
    Department of Neonatology, Charles Nicolle Hospital, Tunis-El Manar University, Tunis, Tunisia.
    We report a rare case of isolated thrombocytopenia related to anti-Ro/SSA antibodies. The mother was followed for unlabeled familial thrombocytopenia. The mother had positive anti-Ro/SSA antibodies. Read More

    Pregnancy-related issues in women with systemic lupus erythematosus.
    Int J Rheum Dis 2015 Feb 25;18(2):172-81. Epub 2014 Dec 25.
    Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
    While fertility is preserved in females with systemic lupus erythematosus (SLE), it is well established that pregnancy in these patients is associated with adverse maternal and fetal outcomes, including pregnancy loss, pre-eclampsia, preterm delivery and intrauterine growth retardation, as well as neonatal mortality. Mechanisms underlying these adverse outcomes are poorly understood, and better understanding of these would allow development of targeted and personalized treatment strategies. Established risk factors for adverse pregnancy outcomes include active disease within 6 months prior to conception and during pregnancy, active nephritis, maternal hypertension, antiphospholipid antibodies and hypocomplementemia. Read More

    [Neonatal lupus and maternofetal transmission of anti-SSA/Ro and anti-SSB/La antibodies].
    Arch Pediatr 2015 Feb 13;22(2):154-9. Epub 2014 Nov 13.
    Laboratoire d'immunologie, université de Sfax, CHU Habib-Bourguiba, Sfax, Tunisie.
    Neonatal lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro (60 and 52kDa) or anti-SSB/La antibodies. The aim of this study was to evaluate the clinical and biological profile of NL at the neonatal unit of Sfax, Tunisia, over a 10-year period. Six mother-NB pairs (two sets of twins and two sisters) had positive ANA by transplacental transmission during the study period. Read More

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