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    680 results match your criteria Neonatal Lupus Erythematosus

    1 OF 14

    Expanding the differential diagnosis of raccoon eyes: Sweet syndrome.
    J Eur Acad Dermatol Venereol 2018 May 31. Epub 2018 May 31.
    Marmara University School of Medicine, Department of Dermatology, Istanbul, Turkey.
    Among the various animal eponyms in dermatology, raccoon eyes sign (RES) is used the characterize the prominent involvement of periorbital skin. The well-known conditions manifesting with RES include neuroblastoma, systemic amyloidosis, skull base fracture and neonatal lupus erythematosus. To our knowledge, the occurrence of RES in Sweet syndrome (SS) has not been reported to date. Read More

    A Critical Review on Obstetric Follow-up of Women Affected by Systemic Lupus Erythematosus.
    Rev Bras Ginecol Obstet 2018 Apr 27;40(4):209-224. Epub 2018 Apr 27.
    Department of Obstetrics and Gynecology, Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.
    Objective:  To review the existing recommendations on the prenatal care of women with systemic lupus erythematosus (SLE), based on currently available scientific evidence.

    Methods:  An integrative review was performed by two independent researchers, based on the literature available in the MEDLINE (via PubMed), EMBASE and The Cochrane Library databases, using the medical subject headings (MeSH) terms "systemic lupus erythematosus" AND "high-risk pregnancy" OR "prenatal care." Studies published in English between 2007 and 2017 were included; experimental studies and case reports were excluded. Read More

    Cutaneous Neonatal Lupus Erythematosus: A Case Report.
    Cureus 2018 Feb 21;10(2):e2212. Epub 2018 Feb 21.
    Sir Seewoosagur Ramgoolam National Hospital.
    Cutaneous neonatal lupus erythematosus (NLE) is a rare condition caused by the passive transfer of autoantibodies from mother to fetus. The disease most commonly presents itself with multiple erythematosus annular lesions or arcuate macules. In 10% of the cases, a cardiac anomaly can coexist. Read More

    Hydroxychloroquine for the prevention of fetal growth restriction and prematurity in lupus pregnancy: A systematic review and meta-analysis.
    Joint Bone Spine 2018 Apr 6. Epub 2018 Apr 6.
    Division of Internal Medicine and Infectious Diseases, Haut-Lévêque Hospital, Pessac, France. Electronic address:
    Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that primarily affects women of childbearing age. While the impact of hydroxychloroquine (HCQ) on SLE activity and neonatal lupus occurrence has been evaluated in several studies, its role on prematurity and intrauterine growth restriction (IUGR) remains uncertain. The aim of this study was to assess the impact of HCQ exposure on prematurity and IUGR during pregnancy in women with SLE. Read More

    NOTCH4 is a possible novel susceptibility gene for dilated cardiomyopathy in the Chinese population: A case-control study.
    J Clin Lab Anal 2018 Mar 26:e22436. Epub 2018 Mar 26.
    Department of Clinical Laboratory, Key Laboratory of Laboratory Medicine of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
    Background: The incidence of dilated cardiomyopathy (DCM) has increased in recent years, and many studies have sought to further improve the general understanding of this condition. Previous studies have demonstrated that some single nucleotide polymorphisms (SNPs) associated with systemic lupus erythematosus also affect susceptibility to DCM, suggesting that immune-related diseases may share similar genetic susceptibility. Recent large-scale and genome-wide association studies have identified NCR3, NOTCH4, CYP1A2, ITGA1, OPRM1, ST8SIA2, and LINC00704 as genetic risk factors associated with cardiac manifestations of neonatal lupus. Read More

    Van Lohuizen Syndrome - A Case Report with a Diagnostic Delay of Four Years.
    Open Access Maced J Med Sci 2018 Jan 2;6(1):74-75. Epub 2018 Jan 2.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR-Sofia), General Skobelev 79, 1606 Sofia, Bulgaria.
    Background: Cutis marmorata telangiectatic congenital or Van Lohuizen syndrome is a rare vascular disorder that may be associated with other congenital malformations. Around 300 cases have been reported so far.

    Case Report: We present a 4-year-old girl with Van Lohuizen syndrome of the leg, but without any other malformations. Read More

    Neonatal and Obstetrical Outcomes of Pregnancies in Systemic Lupus Erythematosus.
    Oman Med J 2018 Jan;33(1):15-21
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman.
    Objectives: Systemic lupus erythematous (SLE) is a chronic autoimmune disease that affects women primarily of childbearing age. The objective of this study was to determine the neonatal and maternal outcomes of pregnancies in SLE patients compared to pregnancies in healthy controls.

    Methods: We conducted a retrospective cohort study in a tertiary care hospital in Oman between January 2007 and December 2013. Read More

    Clinical features of new-onset systemic lupus erythematosus in pregnant patients.
    J Obstet Gynaecol Res 2018 Feb 14;44(2):234-240. Epub 2017 Dec 14.
    Department of Rheumatology, Peking University People's Hospital, Beijing, China.
    Aim: This study was conducted to examine the clinical characteristics of new-onset systemic lupus erythematosus (SLE) during pregnancy.

    Methods: We performed a retrospective study of all pregnancies in patients with SLE managed at The People's Hospital of Peking University from 2008 to 2015. In total, 97 pregnancies were identified and studied, 22 of which were first diagnosed with SLE during pregnancy or puerperium. Read More

    Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome.
    Best Pract Res Clin Rheumatol 2017 Jun 11;31(3):397-414. Epub 2017 Oct 11.
    Department of Rheumatology & Clinical Immunology, SJK-University Hospital Essen, Germany. Electronic address:
    Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with a high prevalence in females of childbearing age. Pregnancy in SLE nowadays has favorable outcomes for the majority of women. However, flares of disease activity, preeclampsia, fetal loss, and preterm birth are well-known risks in such pregnancies. Read More

    Neonatal lupus - case series of a tertiary hospital.
    Acta Reumatol Port 2017 Oct-Dec;42(4):318-323
    Centro Hospitalar de São João, Porto.
    Neonatal lupus (NL) is a very rare condition with an estimated incidence of 1 in 20.000 pregnancies. It is caused by the transplacental passage of autoantibodies anti-Ro/SSA, antiSa/SSB antibodies and/or anti-U1 RNP antibodies into the fetal circulation. Read More

    An evidence-based approach to pre-pregnancy counselling for patients with systemic lupus erythematosus.
    Rheumatology (Oxford) 2017 Nov 20. Epub 2017 Nov 20.
    Department of Gynaecology and Obstetrics, Leiden University Medical Center, Leiden, The Netherlands.
    Patients with SLE are often young females of childbearing age and a pregnancy wish in this patient group is common. However, SLE patients are at high risk for adverse pregnancy outcomes that require adequate guidance. It is widely acknowledged that pre-pregnancy counselling is the pivotal first step in the management of SLE patients with a wish to become pregnant. Read More

    Neonatal Systemic Lupus Erythematosus Syndrome: a Comprehensive Review.
    Clin Rev Allergy Immunol 2017 Dec;53(3):469-476
    Pediatric intermediate care Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
    Neonatal lupus erythematosus is an uncommon syndrome, which is caused by transplacental passage of maternal autoantibodies to Sjögren's syndrome A or B autoantigens. The clinical presentation includes distinctive cutaneous lesions resembling those seen in systemic lupus erythematosus, hepatobiliary disease, and cytopenias, which disappear with the clearance of maternal autoantibodies. The most severe presentation is a total atrioventricular heart block, which begins during the second trimester of gestation and is irreversible. Read More

    Incidence, risk factors, and mortality of neonatal and late-onset dilated cardiomyopathy associated with cardiac neonatal lupus.
    Int J Cardiol 2017 Dec 7;248:263-269. Epub 2017 Aug 7.
    AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares, Paris, France. Electronic address:
    Background: Dilated cardiomyopathy (DCM), a well-known complication of cardiac neonatal lupus, is associated with high mortality rate. Its risk factors remain unclear.

    Methods: We analyzed occurrence of postnatal DCM among children with high-degree congenital heart block (CHB) and mothers with anti-SSA and/or anti-SSB antibodies. Read More

    Clinical and pathologic implications of extending the spectrum of maternal autoantibodies reactive with ribonucleoproteins associated with cutaneous and now cardiac neonatal lupus from SSA/Ro and SSB/La to U1RNP.
    Autoimmun Rev 2017 Sep 12;16(9):980-983. Epub 2017 Jul 12.
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY, United States.
    While the relationship between maternal connective tissue diseases and neonatal rashes was described in the 1960s and congenital heart block in the 1970s, the "culprit" antibody reactivity to the SSA/Ro-SSB/La ribonucleoprotein complex was not identified until the 1980s. However, studies have shown that approximately 10-15% of cases of congenital heart block are not exposed to anti-SSA/Ro-SSB/La. Whether those cases represent a different disease entity or whether another antibody is associated has yet to be determined. Read More

    Neonatal lupus erythematosus.
    Nihon Rinsho Meneki Gakkai Kaishi 2017 ;40(2):124-130
    National Center of Child health and Development, Division of Maternal Medicine, Department of Perinatology.
    Neonatal lupus (NL), a passively-acquired autoimmune disease associated with maternal anti-SSA antibody, presents both cardiac manifestations such as cardiac NL and non-cardiac manifestations including rashes, cytopenia, and hepatic abnormalities. Cardiac NL, occurring in 1-2% of anti-SS-A antibody-positive mothers, is a life-threatening complication with a mortality rate of 20% and a pacemaker implantation rate of 70%. In contrast, cutaneous NL, which is more common than cardiac NL, usually resolves in six months. Read More

    Prenatal exposure to antimalarials decreases the risk of cardiac but not non-cardiac neonatal lupus: a single-centre cohort study.
    Rheumatology (Oxford) 2017 09;56(9):1552-1559
    Department of Rheumatology.
    Objective: Recent studies have suggested that prenatal exposure to HCQ reduces the risk of cardiac neonatal lupus. The aim of this study is to assess if maternal intake of antimalarials (AMs) throughout pregnancy lowered the risk of cardiac and non-cardiac neonatal lupus.

    Methods: Consecutive children seen between 1 January 1984 to 1 October 2013 born to women with a CTD and positive anti-Ro and/or anti-La antibodies were eligible for this single-centre retrospective cohort study. Read More

    Discordant disease expression of neonatal lupus erythematosus in twins.
    J Pak Med Assoc 2017 Jun;67(6):939-941
    Department of Immunology, Shifa International Hospital, Islamabad, Pakistan.
    Neonatal lupus erythematosus is an autoimmune disease resulting from the trans-placental passage of maternal anti-SSA/Ro, anti-SSB/La, and less frequently anti-RNP antibodies to the foetus. At the time of diagnosis 50% of mothers are asymptomatic. Neonatal manifestations of this multisystem disease may include congenital heart block, cutaneous lesions and haematological abnormalities. Read More

    Fetal and neonatal involvement in maternal rheumatologic disease.
    J Matern Fetal Neonatal Med 2018 Aug 8;31(15):2079-2085. Epub 2017 Jun 8.
    a Department of Pediatrics , Hamamatsu University School of Medicine , Hamamatsu , Japan.
    A pregnancy complicated with rheumatologic diseases can have various influences on the fetus and/or neonate. Maternal systemic lupus erythematosus (SLE) may cause preterm and/or small for gestational age (SGA) delivery and neonatal lupus (NL). Some neonates with NL have congenital heart block (CHB) with increased morbidity and mortality, even requiring pacemakers. Read More

    Progress in the pathogenesis and treatment of cardiac manifestations of neonatal lupus.
    Curr Opin Rheumatol 2017 Sep;29(5):467-472
    New York University School of Medicine, New York, New York, USA.
    Purpose Of Review: To provide new insights into pathogenesis, prevention and management of cardiac manifestations of neonatal lupus (cardiac neonatal lupus) and issues pertinent to all anti-SSA/Ro positive individuals of childbearing age.

    Recent Findings: Antibody specificity with high risk for cardiac neonatal lupus remains elusive, but high titers of Ro60, Ro52 or Ro52p200 antibodies appear to be required. Varying antibody specificities to the p200 region of Ro52 can induce first-degree block in a rodent model. Read More

    High maternal expression of SIGLEC1 on monocytes as a surrogate marker of a type I interferon signature is a risk factor for the development of autoimmune congenital heart block.
    Ann Rheum Dis 2017 Aug 13;76(8):1476-1480. Epub 2017 May 13.
    Department of Rheumatology and Clinical Immunology, Charité Universitätsmedizin Berlin, Berlin, Germany.
    Objectives: Autoimmune congenital heart block (CHB) is associated with placental transcytosis of maternal autoantibodies directed against Ro/SS-A and La/SS-B. However, only about 2% of children born to mothers with the respective antibodies are affected, indicating that further risk factors exist, which are not yet fully understood. In this study, we investigated whether a maternal type I interferon (IFN) signature represents a risk factor for the development of CHB. Read More

    Myocarditis, flail tricuspid valve, and normal rhythm: an exceptional form of neonatal cardiac lupus.
    Cardiol Young 2017 Sep 2;27(7):1419-1422. Epub 2017 May 2.
    1Pediatric Cardiac Surgery Department,Gregorio Marañón Hospital,Madrid,Spain.
    Neonatal cardiac lupus is a rare, passively acquired autoimmune disease. We report a case of in utero myocarditis, confirmed postnatally, with papillary muscle rupture and severe tricuspid regurgitation after birth in the absence of conduction disturbances. Tricuspid repair was successfully performed with polytetrafluoroethylene neochordae. Read More

    Systemic Lupus Erythematosus and Pregnancy.
    Rheum Dis Clin North Am 2017 05 14;43(2):215-226. Epub 2017 Mar 14.
    Division of Rheumatology, Johns Hopkins Lupus Center, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 7500, Baltimore, MD 21205, USA. Electronic address:
    Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong female predilection. Pregnancy remains a commonly encountered but high-risk situation in this setting. Both maternal and fetal mortality and morbidity are still significantly increased despite improvements in outcomes. Read More

    The Child as a Surrogate for Diagnosis of Lupus in the Mother.
    Case Rep Rheumatol 2017 13;2017:8247591. Epub 2017 Mar 13.
    Rheumatology Unit, Department of Internal Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria.
    Neonatal lupus erythematosus (NLE) is an acquired disease of the newborn caused by transplacental transfer of maternal anti-Ro/SSA, anti-La/SSB, and infrequently anti-U1 RNP antibodies. This is a case report of a male infant delivered via Caesarean section at 36-week gestation following detection of fetal bradycardia during routine antenatal clinic visit. The mother was seropositive for antinuclear antibody (ANA) and anti-Ro/SSA and had elevated erythrocyte sedimentation rate. Read More

    Management of systemic lupus erythematosus during pregnancy: challenges and solutions.
    Open Access Rheumatol 2017 10;9:37-53. Epub 2017 Mar 10.
    Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, St Thomas' Hospital, London, UK.
    Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease predominantly affecting women, particularly those of childbearing age. SLE provides challenges in the prepregnancy, antenatal, intrapartum, and postpartum periods for these women, and for the medical, obstetric, and midwifery teams who provide their care. As with many medical conditions in pregnancy, the best maternal and fetal-neonatal outcomes are obtained with a planned pregnancy and a cohesive multidisciplinary approach. Read More

    Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.
    Autoimmun Rev 2017 Apr 14;16(4):427-432. Epub 2017 Feb 14.
    Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
    Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur. Read More

    A complicated multisystem flare of systemic lupus erythematosus during pregnancy.
    BMJ Case Rep 2017 Feb 8;2017. Epub 2017 Feb 8.
    Imperial College London, London, UK.
    We report a case of systemic lupus erythematosus (SLE) in a young woman who became pregnant amid a severe flare. She continued to have active disease in the face of aggressive treatments complicated by several side effects of immunosuppressive drugs including recurrent sepsis and gestational diabetes. Her fetus was at risk for congenital heart block during the second and third trimesters. Read More

    Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.
    Immunol Res 2017 04;65(2):487-494
    Obstetric and Gynecology Department, High Risk Pregnancy Unit, Autoimmune diseases and pregnancy clinic, University Hospital La Paz, Paseo de la Castella 261, 28046, Madrid, Spain.
    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). Read More

    Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
    J Autoimmun 2017 May 22;79:99-104. Epub 2017 Jan 22.
    Dept. Medicine, Division of Rheumatology, New York University School of Medicine, New York, USA.
    The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response. Read More

    [Down syndrome and heart block secondary to neonatal lupus].
    Rev Med Inst Mex Seguro Soc 2017 Jan-Feb;55(1):128-132
    Departamento de Cardiología Pediátrica, Hospital General Regional 36, Instituto Mexicano del Seguro Social, Puebla, Puebla, México.
    In Down syndrome, so far, has not been reported it's association with congenital heart block, this entity is rare and occurred in only 1% of mothers who have systemic lupus erythematosus, the presence of anti-Ro antibodies cross the placenta presenting neonatal lupus with skin lesions and congenital heart block, bradycardia, which is why we describe the following case. This is a new male end product of asymptomatic young mother, but serological birth with stigmata of Down syndrome, birth presents congenital bradycardia rare manifestation abnormalities, but common in children of mothers with lupus are initiated study protocol, realizing you including laboratory tests and immunological studies cabinet as electrocardiogram and echocardiogram, which gave tone to take the mother immunological studies, being positive antiRo. We concluded that the risk of heart block in a patient with Down syndrome is the same as for the general population. Read More

    Sjögren Syndrome and Pregnancy: A Literature Review.
    Perm J 2017 9;21. Epub 2016 Nov 9.
    Fellow in Clinical Immunology & Rheumatology at the Christian Medical College in Vellore, India.
    Objectives: Autoimmune diseases do not impair fertility, and women with autoimmune diseases who become pregnant are likely to experience more complicated pregnancies than are women without the disease. Pregnancies complicated by these disorders have a high clinical impact on both the pregnancy and the disease. The effect of autoimmune disease on pregnancy differs according to the type of maternal disease, disease activity, severity of organ damage, antibody profile, and drug treatment. Read More

    Neonatal lupus erythematosus with congenital heart block in twins.
    Tunis Med 2016 Jul;94(7):401-404
    Background - Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by transplacental passage of maternal antibodies SSA/Ro, SSB/La or U1 ribonucleoproteins. The most common clinical manifestations are skin rash, cardiac lesions, thrombocytopenia, anemia and hepatosplenomegaly. Complete congenital heart block is usually irreversible needing a pacemaker implantation in two-thirds of cases. Read More

    Neonatal lupus erythematosus: Report of a case with cutaneous, hematological and hepatobiliary findings.
    Turk J Pediatr 2016 ;58(1):106-108
    Marmara University School of Medicine Department of Dermatology, İstanbul, Turkey.
    Neonatal lupus erythematosus is an autoimmune disorder mainly affecting the heart and skin. It is the most common cause of congenital heart block. In addition, hematological, hepatobiliary and neurological involvement may occur. Read More

    [Clinical features and adverse pregnancy outcomes of new onset systemic lupus erythematosus during pregnancy].
    Zhonghua Yi Xue Za Zhi 2016 Nov;96(41):3300-3304
    Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
    To investigate the clinical characteristics and adverse pregnancy outcomes in pregnant women with new onset systemic lupus erythematosus (SLE) during pregnancy. The clinical data of 263 pregnancies with SLE in the First Affiliated Hospital of Zhongshan University from 2001 to 2015 were collected and analyzed retrospectively. Of all the 263 pregnancies, 188 were diagnosed before pregnancy and 75 were newly diagnosed during pregnancy. Read More

    Innate and humoral recognition of the products of cell death: differential antigenicity and immunogenicity in lupus.
    Clin Exp Immunol 2017 Mar 5;187(3):353-368. Epub 2016 Dec 5.
    National Institute of Immunology, New Delhi, India.
    While apoptotic debris is believed to constitute the original antigenic insult in lupus (which is characterized by a time-dependent diversification of autoreactivity), whether such debris and autoantibodies specifically recognizing its constituents mediate differential effects on innate and humoral responses in lupus-prone mice is currently unknown. Apoptotic blebs (as opposed to cellular lysate) enhanced preferentially the maturation of dendritic cells (DCs) from bone marrow precursors drawn from lupus-prone mice. Murine, somatically mutated, apoptotic cell-reactive immunoglobulin (Ig)G monoclonal antibodies demonstrated enhanced recognition of DCs and also displayed a prominent lupus strain-specific bias in mediating DC maturation. Read More

    A comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus.
    J Autoimmun 2016 Nov 2;74:106-117. Epub 2016 Jul 2.
    Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. Electronic address:
    Nowadays, most of the young women affected by Systemic Lupus Erythematosus (SLE) can carry out one or more pregnancies thanks to the improvement in treatment and the consequent reduction in morbidity and mortality. Pregnancy outcome in these women has also greatly improved in the last decades. A correct timing for pregnancy (tailored on disease activity and established during a preconception counselling), together with a tight monitoring during the three trimesters and the post-partum period (to timely identify and treat possible obstetric complications or maternal disease flares), as well as the concept of multidisciplinary management, are currently milestones of the management of pregnancy in SLE patients. Read More

    Management of Pregnancy in Lupus Patients.
    J Assoc Physicians India 2016 Aug;64(8):62-66
    Assistant Professor, Department of Surgery, MG Medical College, Jaipur, Rajasthan.
    Systemic lupus erythematosus (SLE) mostly affects young women of reproductive age group. SLE patients may conceive as any normal woman but complication may occur in these patients if the disease is active. Pregnancy in SLE may lead to 1. Read More

    Management of Systemic Lupus Erythematosus During Pregnancy.
    Annu Rev Med 2017 01 21;68:271-285. Epub 2016 Sep 21.
    Hospital for Special Surgery, Weill Cornell Medicine, New York, NY 10021; email:
    Reproductive issues including contraception, fertility, and pregnancy are important components of the comprehensive care of women with systemic lupus erythematosus (SLE). SLE pregnancies are complicated due to risk for maternal disease exacerbation and potential for fetal and neonatal complications. Pre-pregnancy assessment is important to identify patients with severe disease-related damage who should avoid pregnancy, counsel patients to conceive when disease has been stable and inactive on appropriate medications, and assess relevant risk factors including renal disease, antiphospholipid antibody, and anti-Ro/SS-A and anti-La/SS-B antibodies. Read More

    Correlation of Maternal Autoantibodies with Fetal Congenital Heart Block.
    J Obstet Gynaecol India 2016 Oct 17;66(Suppl 1):112-6. Epub 2015 Dec 17.
    Department of Obstetrics and Gynecology, Armed Forces Medical College, Pune, 411040 India.
    Background: Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was conducted to know the incidence of fetal CHB in patients of SLE who had ANA, anti-Ro/SSA and anti-La/SSB positivity. Read More

    Outcome of pregnancy in patients with systemic lupus erythematosis at Korle-bu Teaching Hospital.
    Ghana Med J 2016 Jun;50(2):72-7
    Department of Medicine and Therapeutics, Korle-bu Teaching Hospital, P.O. Box KB 77 Accra, Ghana; School of Medicine and Dentistry, College of Health Sciences, University of Ghana P.O. Box GP 4236, Accra.
    Objective: To study maternal and fetal outcomes in Ghanaian women with systemic lupus erythematosus (SLE).

    Methods: Retrospective study of pregnancies in women with SLE in a single centre in Ghana.

    Results: The mean age was 30. Read More

    Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.
    Clin Exp Immunol 2016 Dec 13;186(3):284-291. Epub 2016 Sep 13.
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist. Read More

    Warm antibody hemolytic anemia-a rare presentation of neonatal lupus.
    Lupus 2017 May 11;26(6):661-663. Epub 2016 Aug 11.
    1 Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
    Neonatal lupus erythematosus (NLE) affects 1%-2% pregnant females with autoimmunity. An infant presented with steroid refractory hemolytic anemia as a manifestation of NLE. A trial of withholding breastfeeding had a transient response, but infant was eventually put on cyclosporin therapy to control the hemolysis. Read More

    A 3-Day-Old Girl Referred From Her Pediatrician for Oral Ulcerations.
    Pediatrics 2016 Sep 9;138(3). Epub 2016 Aug 9.
    Children's National Medical Center, Washington, District of Columbia.
    A 3-day-old girl was referred from her pediatrician for oral ulcerations. The patient was otherwise well appearing and afebrile. Her prenatal and antenatal courses were unremarkable, except for a failed routine hearing screen. Read More

    Neonatal Lupus: What We Have Learned and Current Approaches to Care.
    Curr Rheumatol Rep 2016 Sep;18(9):60
    Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, 225 E. Chicago Avenue, # 50, Chicago, IL, 60611, USA.
    Neonatal lupus results from the passive transfer of autoantibodies; however, this transfer is not sufficient to cause disease. This article reviews clinical presentation with a focus on autoimmune-mediated congenital heart disease. Recent data looking for additional disease mechanisms and biomarkers as well as latest information on interventions will be reviewed. Read More

    Autoantibodies in Sjögren's Syndrome.
    Rheum Dis Clin North Am 2016 08 21;42(3):419-34. Epub 2016 Jun 21.
    Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 Northeast, 13th Street, Oklahoma City, OK 73104, USA; Department of Medicine, College of Medicine, 1000 N Lincoln Boulevard, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Medical and Research Services, US Department of Veterans Affairs Hospital, 921 NE 13th Street, Oklahoma City, OK 73104, USA. Electronic address:
    We compiled information on antibodies in Sjögren syndrome, focusing more on clinical manifestations associated with anti-Ro/SSA and anti-La/SSB antibodies and studies regarding novel antibodies. We reviewed previous as well as most recent studies with the subject heading Sjogren in combination with antibodies and congenital heart block (CHB). Almost half of asymptomatic mothers giving birth to children with CHB ultimately develop Sjögren. Read More

    The Unique Coexistence of Anti-SS-A/Ro Antibodies in a Neonate with Symptomatic Ischemic Stroke.
    Pediatr Neurol 2016 09 15;62:47-50. Epub 2016 Jun 15.
    Department of Pediatrics, Hikone Municipal Hospital, Hikone, Shiga, Japan.
    Background: Neonatal cerebral infarction is a relatively common cause of neonatal seizures, with an incidence of at least 1:4000 live births and is associated with a high incidence of neurological sequelae. However, the pathophysiological mechanisms and predisposing factors responsible for neonatal infarction are not fully established.

    Patient Description: A full-term baby boy was transferred at two days of age for the treatment of a cluster of seizures. Read More

    Long-Term Follow-Up of Children with Heart Block Born from Mothers with Systemic Lupus Erythematosus: A Retrospective Study from the Database Pediatric and Congenital Heart Disease in University Hospitals Leuven.
    Pacing Clin Electrophysiol 2016 Sep 2;39(9):935-43. Epub 2016 Aug 2.
    Congenital and Structural Cardiology, University Hospitals Leuven, Leuven, Belgium.
    Background: Children from mothers with systemic lupus erythematosus are frequently born with congenital heart block. This study aimed at evaluating long-term outcome because long-term data are scarce.

    Methods: In the database of pediatric and congenital heart disease (University Hospitals Leuven), 19 children from systemic lupus erythematosus mothers and who were born with or developed atrioventricular block were identified. Read More

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