56,143 results match your criteria Nematode Infections


Anti-MRSA agent discovery using Caenorhabditis elegans-based high-throughput screening.

J Microbiol 2020 Jun 27;58(6):431-444. Epub 2020 May 27.

College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.

Staphylococcus aureus is a leading cause of hospital- and community-acquired infections. Despite current advances in antimicrobial chemotherapy, the infections caused by S. aureus remain challenging due to their ability to readily develop resistance. Read More

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http://dx.doi.org/10.1007/s12275-020-0163-8DOI Listing

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

PLoS Negl Trop Dis 2020 May 26;14(5):e0008237. Epub 2020 May 26.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008237DOI Listing

Performance of two serodiagnostic tests for loiasis in a Non-Endemic area.

PLoS Negl Trop Dis 2020 May 26;14(5):e0008187. Epub 2020 May 26.

IRCCS Sacro Cuore Don Calabria Hospital, Center for Tropical Diseases, Negrar, Verona, Italy.

Loiasis, caused by the filarial nematode Loa loa, is endemic in Central and West Africa where about 10 million people are infected. There is a scarcity of convenient, commercial diagnostics for L. loa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008187DOI Listing

Comparison of ITS-2 rDNA nemabiome sequencing with morphological identification to quantify gastrointestinal nematode community species composition in small ruminant feces.

Vet Parasitol 2020 Apr 29;282:109104. Epub 2020 Apr 29.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, 50 Stone Road E, Guelph, Ontario, N1G 2W1, Canada. Electronic address:

Mixed gastrointestinal nematode (GIN) infections are a common and significant cause of financial loss for small ruminant producers. Morphologic examination of third-stage larvae (L) can be used to identify species composition in feces but has limitations due to the requirement for specialized expertise and the extensive time (8-15 d depending on method used) and labour involved. Moreover, differential development and survival of larvae during coproculture to the third stage often occurs. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109104DOI Listing

Effect of Genotype and Sex of the Host on the Bioavailability of Novel Albendazole Microcrystals Based on Chitosan and Cellulose Derivatives.

AAPS PharmSciTech 2020 May 20;21(5):149. Epub 2020 May 20.

IQUIR-CONICET, Suipacha 570, S2002LRK, Rosario, Argentina.

Albendazole (ABZ), an anthelmintic compound widely used in the treatment of systemic nematode infections, is included in the list of class II drugs based on the Biopharmaceutical Classification System. ABZ has limited effectiveness due to its poor water solubility and consequent low bioavailability. Bioavailability of novel ABZ microcrystals based on hydroxyethylcellulose (S4A) or chitosan (S10A) was studied in male and female mice of two inbred lines, from the murine CBi-IGE model of trichinellosis, differing in susceptibility to this parasitosis (line CBi/L, resistant; line CBi+, susceptible). Read More

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http://dx.doi.org/10.1208/s12249-020-01692-2DOI Listing

Molecular and microscopic detection of natural and experimental infections of Toxocara vitulorum in bovine milk.

PLoS One 2020 20;15(5):e0233453. Epub 2020 May 20.

Department of Parasitology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.

Toxocara vitulorum is an Ascarid nematode infecting the small intestine of buffalo and cattle particularly neonate calves, with the postnatal route through milk is the main infection source. However, little is known about shedding rates and the optimum detection methods of T. vitulorum larvae in the milk of the infected bovine hosts. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233453PLOS

Efficiency of vanillin in impeding metabolic adaptability and virulence of by inhibiting glyoxylate cycle, morphogenesis, and biofilm formation.

Curr Med Mycol 2020 ;6(1):1-8

Amity Institute of Biotechnology, Amity University Haryana, Gurugram, India.

Background And Purpose: is the fourth most common cause of nosocomial fungal infections across the world. The current drug regimens are suffering from such drawbacks as drug resistance, toxicity, and costliness; accordingly, they highlight the need for the discovery of novel drug agents. The metabolic adaptability under low-carbon conditions and expression of functional virulence traits mark the success of pathogens to cause infection. Read More

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http://dx.doi.org/10.18502/cmm.6.1.2501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217250PMC
January 2020

The effect of the hibernation on the larval development of Troglostrongylus brevior in the land snail Cornu aspersum.

Vet Parasitol 2020 Apr 27;282:109123. Epub 2020 Apr 27.

Faculty of Veterinary Medicine, University of Teramo, Italy.

Troglostrongylus brevior, a lungworm affecting wild felids, has been increasingly reported in domestic cats from Europe. Troglostrongylosis is a relevant disease that may result in a potentially life-threatening bronchopneumonia, especially in kittens. The life cycle of T. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109123DOI Listing

Evaluation of the effect of Toxocara cati infection in the mouse model of allergic asthma: Exacerbation of allergic asthma symptoms and Th2 types of response.

Comp Immunol Microbiol Infect Dis 2020 Apr 22;71:101488. Epub 2020 Apr 22.

Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:

Toxocariasis is considered a neglected disease despite the importance of Toxocara spp. infections for human health and is little recognized as a significant problem by public health institutions in developing countries. Epidemiological studies suggest that infection with Toxocara cati contributes to the development of allergic asthma. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101488DOI Listing

Single-Dose Triple-Drug Therapy for - 5-Year Follow-up.

N Engl J Med 2020 05;382(20):1956-1957

Case Western Reserve University School of Medicine, Cleveland, OH.

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http://dx.doi.org/10.1056/NEJMc1914262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175637PMC

Immunoreactivity of proteins within 30-40 kDa range during the acute and the recovery phases in rats experimentally infected with Strongyloides venezuelensis.

Rev Inst Med Trop Sao Paulo 2020 11;62:e23. Epub 2020 May 11.

Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, São Paulo, Brazil.

In experimental infection with Strongyloides venezuelensis, the acute and recovery phases can be distinguished, unlike human infections caused by Strongyloides stercoralis. The objective of this study was to evaluate the production of anti-Strongyloides IgG antibodies and the recognition of immunogenic protein bands during the acute and the recovery phases in rats experimentally infected with S. venezuelensis. Read More

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http://dx.doi.org/10.1590/s1678-9946202062023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232957PMC

High frequency of benzimidazole resistance alleles in trichostrongyloids from Austrian sheep flocks in an alpine transhumance management system.

BMC Vet Res 2020 May 11;16(1):132. Epub 2020 May 11.

Department for Farm Animals and Veterinary Public Health, University Clinic for Ruminants, Vetmeduni Vienna, Veterinärplatz 1, 1210, Vienna, Austria.

Background: Infections of small ruminants with trichostrongyloid nematodes often result in reduced productivity and may be detrimental to the host. Anthelmintic resistance (AR) against most anthelmintic drug classes is now widespread amongst the trichostrongyloids. Baseline establishment, followed by regular monitoring of the level of AR, is necessary for farmers and veterinarians to make informed decisions about parasite management. Read More

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http://dx.doi.org/10.1186/s12917-020-02353-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216349PMC

Urban-rural differences in immune responses to mycobacterial and tetanus vaccine antigens in a tropical setting: A role for helminths?

Parasitol Int 2020 May 5;78:102132. Epub 2020 May 5.

Immunomodulation and Vaccines Programme, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda. Electronic address:

Several vaccines elicit lower efficacy or impaired immune responses in rural compared to urban settings, and in tropical low-income countries compared to high-income countries. An unresolved hypothesis is that immunomodulation by parasitic infections such as helminths (prevalent in rural tropical settings) contributes to suppression of vaccine responses. Among 1-17-year-old Ugandan residents of rural Schistosoma mansoni (Sm)-endemic islands and proximate urban communities with lower helminth exposure, we assessed plasma antibody and whole blood assay cytokine responses to tetanus toxoid (TT) and purified protein derivative of Mycobacterium tuberculosis (PPD). Read More

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http://dx.doi.org/10.1016/j.parint.2020.102132DOI Listing

Immunoglobulins as Biomarkers for Gastrointestinal Nematodes Resistance in Small Ruminants: A systematic review.

Sci Rep 2020 May 8;10(1):7765. Epub 2020 May 8.

URZ, Unité de Recherches Zootechniques, INRA, 97170, Petit Bourg, (Guadeloupe), France.

The rise of anthelmintic resistance worldwide has led to the development of alternative control strategies for gastrointestinal nematodes (GIN) infections, which are one of the main constraints on the health of grazing small ruminants. Presently, breeding schemes rely mainly on fecal egg count (FEC) measurements on infected animals which are time-consuming and requires expertise in parasitology. Identifying and understanding the role of immunoglobulins in the mechanisms of resistance could provide a more efficient and sustainable method of identifying nematode-resistant animals for selection. Read More

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http://dx.doi.org/10.1038/s41598-020-64775-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210940PMC

Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence.

Evid Based Complement Alternat Med 2020 22;2020:1043471. Epub 2020 Apr 22.

Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium.

Background: Infections by microbes (viruses, bacteria, and fungi) and parasites can cause serious diseases in both humans and animals. Heavy use of antimicrobials has created selective pressure and caused resistance to currently available antibiotics, hence the need for finding new and better antibiotics. Natural products, especially from plants, are known for their medicinal properties, including antimicrobial and anthelmintic activities. Read More

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http://dx.doi.org/10.1155/2020/1043471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193273PMC
April 2020
1.880 Impact Factor

Antigen detection: Insights into Toxocara and other ascarid infections in dogs and cats.

Authors:
David A Elsemore

Adv Parasitol 2020 10;109:545-559. Epub 2020 Feb 10.

IDEXX Laboratories, Inc., Westbrook, ME, United States. Electronic address:

Detection of ascarid excreted or secreted (E/S) molecules is an alternative approach to the identification of infection by egg flotation. E/S molecules serve as direct markers for the ascarid nematode commonly found in cats and dogs (Toxocara spp., Toxascaris leonina and Baylisascaris procyonis). Read More

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http://dx.doi.org/10.1016/bs.apar.2020.01.034DOI Listing
February 2020

Toxocara-induced neural larva migrans (neurotoxocarosis) in rodent model hosts.

Adv Parasitol 2020 10;109:189-218. Epub 2020 Feb 10.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hanover, Germany.

Neural larva migrans (NLM), or neurotoxocarosis, induced by Toxocara canis or Toxocara cati results from migrating and persisting larvae in the central nervous system of paratenic hosts, including humans. As the diagnosis of NLM in humans is not straightforward, most knowledge on the disease is derived from only a few published clinical cases. To improve our understanding of human NLM, studies on the pathogenesis and clinical symptoms in laboratory animal model systems are indispensable, and rodents have been accepted as the most appropriate model organisms for NLM. Read More

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http://dx.doi.org/10.1016/bs.apar.2020.01.006DOI Listing
February 2020

Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8.

iScience 2020 May 18;23(5):101068. Epub 2020 Apr 18.

Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address:

Cholesterol is an essential nutrient for the function of diverse biological processes and for steroid biosynthesis across metazoans. However, the role of cholesterol in immune function remains understudied. Using the nematode Caenorhabditis elegans, which depends on the external environment for cholesterol, we studied the relationship between cholesterol and innate immunity. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195545PMC

Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya.

J Trop Med 2020 14;2020:4124808. Epub 2020 Apr 14.

Embakasi Medical Health Centre and Mukuru Health Centre, P.O. Box 30108-00100, Nairobi, Kenya.

Background: The burden of nematode infections is high mostly in children below 5 years old, with clinical manifestations ranging from mild to painful symptoms due to severe infections that end up suppressing the immune system of the infected children. The occurrence of these infections is highest in areas of extreme poverty. This study evaluated the intensity of nematode infections and assessed the status of deworming in children aged 3 to 5 years living in Mukuru slum settlement, Nairobi County, Kenya. Read More

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http://dx.doi.org/10.1155/2020/4124808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178522PMC

Real-time detection and identification of nematode eggs genus and species through optical imaging.

Sci Rep 2020 Apr 29;10(1):7219. Epub 2020 Apr 29.

School of Physics, University of Melbourne, Parkville, 3010, Australia.

Nematode eggs are pervasive pathogens that infect billions of people and livestock every year. Adult parasitic nematode worms can be distinguished based on their size and morphology. However, their eggs, particularly their species Ascaris lumbricoides and Ascaris suum cannot be identified from each other. Read More

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http://dx.doi.org/10.1038/s41598-020-63747-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190725PMC

Detection of Cercopithifilaria bainae infection in shelter dogs and ticks in Oklahoma, USA.

Parasit Vectors 2020 Apr 25;13(1):216. Epub 2020 Apr 25.

Department of Veterinary Pathobiology, Oklahoma State University College of Veterinary Medicine, Stillwater, OK, USA.

Background: Cercopithifilaria bainae is a filarioid nematode of dogs. Infection with the parasite was not reported in the USA until 2017, when a dog with skin lesions in Florida was diagnosed. Brown dog ticks, Rhipicephalus sanguineus (sensu lato), are the purported tick vectors, and are widespread in the USA. Read More

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http://dx.doi.org/10.1186/s13071-020-04089-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183667PMC

The global status of Dirofilaria immitis in dogs: a systematic review and meta-analysis based on published articles.

Res Vet Sci 2020 Apr 10;131:104-116. Epub 2020 Apr 10.

Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

Dirofilaria immitis is a parasitic filarial nematode responsible for heartworm disease in domestic as well as wild canines and felines and pulmonary or cutaneous infections in humans. This systematic review and meta-analysis aimed to evaluate the status of D. immitis in dogs based on available literature. Read More

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http://dx.doi.org/10.1016/j.rvsc.2020.04.002DOI Listing

Gastro-intestinal nematodes in goats in Bangladesh: A large-scale epidemiological study on the prevalence and risk factors.

Parasite Epidemiol Control 2020 May 4;9:e00146. Epub 2020 Apr 4.

Department of Parasitology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.

Goats greatly influence the economic sustainability of rural communities. However, parasitic diseases, especially gastrointestinal nematodes (GINs) are a major constraint on profitable small ruminants' production worldwide. During July- 2015 to June- 2016, we conducted a cross sectional study within seven topographic zones of Bangladesh to explore the level of infection and associated risk factors of GINs infections of goats. Read More

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http://dx.doi.org/10.1016/j.parepi.2020.e00146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171516PMC

CD8 regulatory T cells are critical in prevention of autoimmune-mediated diabetes.

Nat Commun 2020 Apr 22;11(1):1922. Epub 2020 Apr 22.

Department of Parasitology, National Institute of Infectious Disease, Tokyo, 162-8640, Japan.

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Read More

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http://dx.doi.org/10.1038/s41467-020-15857-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176710PMC

First Molecular Characterization of Trichostrongylus colubriformis Infection in Rural Patients from Chile.

Acta Parasitol 2020 Apr 21. Epub 2020 Apr 21.

Department of Preclinical Sciences, Medicine Faculty, Laboratory of Molecular Immunoparasitology, Center of Translational Medicine Scientific and Technological Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco, Chile.

Purpose: The aim was to characterize the infection by Trichostrongylus spp. in patients from Chile using a combination of molecular detection techniques and phylogenetic analysis relating the findings to clinical and epidemiological reports of the patients METHODS: Strongylid eggs were detected in seven patients by coproparasitological techniques. From each sample a fragment of the ITS-2 ribosomal gene was amplified by PCR, sequenced and analyzed by the Neighbor-Joining method. Read More

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http://dx.doi.org/10.2478/s11686-020-00206-1DOI Listing
April 2020
0.965 Impact Factor

Capillaria boehmi (syn. Eucoleus boehmi): Challenging treatment of a rarely diagnosed nasal nematode in dogs and high prevalence in Swiss foxes.

Vet Parasitol 2020 May 9;281:109103. Epub 2020 Apr 9.

Institute of Parasitology, Vetsuisse-Faculty, University of Zurich, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Despite morphological differences of eggs and adults, Capillaria boehmi infections have been occasionally misdiagnosed as C. aerophila infections in the past. Capillaria boehmi is found in the nasal and paranasal sinuses of wild canids and dogs, which may suffer from nasal discharge, sneezing, epistaxis and, importantly, their scent can be impaired. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109103DOI Listing

Identification of High-Risk Pregnancies in a Remote Setting Using Ambulatory Blood Pressure: The MINDI Cohort.

Front Public Health 2020 24;8:86. Epub 2020 Mar 24.

School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, QC, Canada.

Ambulatory blood pressure is a potential tool for early detection of complications during pregnancy, but its utility in impoverished settings has not been assessed. This cross-sectional study aimed to determine whether maternal infections, nutrient deficiencies and inflammation (MINDI) were associated with four measures of maternal blood pressure (BP) and to determine their association with symphysis-fundal-height (SFH). Environmental and dietary factors, intake of iron and a multiple-nutrient supplement (MNS), markers of inflammation, protein, anemia, folate, vitamins B, A and D status, and urogenital, skin, oral and intestinal nematode infections were measured in indigenous pregnant Panamanian women. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121149PMC

A perspective on the discovery of selected compounds with anthelmintic activity against the barber's pole worm-Where to from here?

Adv Parasitol 2020 4;108:1-45. Epub 2020 Mar 4.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, Australia. Electronic address:

Parasitic roundworms (nematodes) cause substantial morbidity and mortality in animals worldwide. Anthelmintic treatment is central to controlling these worms, but widespread resistance to most of the commercially available anthelmintics for veterinary and agricultural use is compromising control, such that there is an urgency to discover new and effective drugs. The purpose of this article is to review information on parasitic nematodes, the treatment and control of parasitic nematode infections and aspects of discovering new anthelmintics in the context of anthelmintic resistance problems, and then to discuss some progress that our group has made in identifying selected compounds with activity against nematodes. Read More

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http://dx.doi.org/10.1016/bs.apar.2019.12.003DOI Listing

Species identification of Trichinella originated from various host and different geographical location by MALDI-TOF.

Exp Parasitol 2020 Jun 6;213:107890. Epub 2020 Apr 6.

JRU BIPAR, ANSES, Alfort National Veterinary School, INRA, Animal Health Laboratory, 14 Rue Pierre et Marie Curie, 94701, Maisons-Alfort Cedex, France.

The foodborne zoonotic nematode Trichinella spp. can cause human trichinellosis when raw or undercooked contaminated meat is ingested. To date, twelve Trichinella species/genotypes have been described. Read More

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http://dx.doi.org/10.1016/j.exppara.2020.107890DOI Listing

Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.

PLoS Pathog 2020 Apr 9;16(4):e1008465. Epub 2020 Apr 9.

School of Biomedical Science, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.

Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies on anthelmintic drugs to which roundworms are becoming increasingly resistant. An alternative approach is control by vaccination and 'hidden antigens', components of the worm gut not encountered by the infected host, have been exploited to produce Barbervax, the first commercial vaccine for a gut dwelling nematode of any host. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173941PMC

Infection with Inhibits the Production of IgE Antibodies to α-Gal in Humans: Towards a Conceptual Framework of the Hygiene Hypothesis?

Vaccines (Basel) 2020 Apr 6;8(2). Epub 2020 Apr 6.

UMR BIPAR, INRAE, ANSES, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 94706 Maisons-Alfort, France.

α-Gal syndrome (AGS) is a type of anaphylactic reaction to mammalian meat characterized by an immunoglobulin (Ig)E immune response to the oligosaccharide α-Gal (Galα1-3Galβ1-4GlcNAc-R). Tick bites seems to be a prerequisite for the onset of the allergic disease in humans, but the implication of non-tick parasites in α-Gal sensitization has also been deliberated. In the present study, we therefore evaluated the capacity of helminths (, , ), protozoa (), and parasitic fungi () to induce an immune response to α-Gal. Read More

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http://dx.doi.org/10.3390/vaccines8020167DOI Listing

Large scale screening for benzimidazole resistance mutations in Nematodirus battus, using both pyrosequence genotyping and deep amplicon sequencing, indicates the early emergence of resistance on UK sheep farms.

Int J Parasitol Drugs Drug Resist 2020 04 6;12:68-76. Epub 2020 Mar 6.

Department of Disease Control, Moredun Research Institute, Pentlands Science Park, Bush Loan, EH26 0PZ, UK.

Benzimidazoles (BZ) have been the anthelmintic of choice for controlling Nematodirus battus infections since their release in the 1950s. Despite heavy reliance on this single anthelmintic drug class, resistance was not identified in this nematode until 2010 (Mitchell et al., 2011). Read More

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http://dx.doi.org/10.1016/j.ijpddr.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132121PMC

Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat.

PLoS Negl Trop Dis 2020 Apr 3;14(4):e0008218. Epub 2020 Apr 3.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, PR China.

CD4+ T cells play critical roles in mediating adaptive immunity to a variety of pathogens. Recently, new subset of CD4+T named as T helper 9 cells that express the prototypical interleukin-9 (IL-9) cytokine have been recognized in human and mice models during different parasitic infections. Haemonchus contortus is a gastrointestinal nematode of small ruminants which cause high mortality in young animals. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159227PMC

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation.

Parasit Vectors 2020 Apr 1;13(1):162. Epub 2020 Apr 1.

Department of Biology, Millersville University of Pennsylvania, Millersville, PA, 17551, USA.

Background: While immune responses to the murine hookworm Nippostrongylus brasiliensis have been investigated, signaling pathways regulating development of infectious larvae (iL3) are not well understood. We hypothesized that N. brasiliensis would use pathways similar to those controlling dauer development in the free-living nematode Caenorhabditis elegans, which is formally known as the "dauer hypothesis. Read More

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http://dx.doi.org/10.1186/s13071-020-04035-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110753PMC

Detection of Dirofilaria immitis using microscopic, serological and molecular techniques among dogs in Cabo Frio, RJ, Brazil.

Rev Bras Parasitol Vet 2020 30;29(1):e017219. Epub 2020 Mar 30.

Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense - UFF, Rio de Janeiro, RJ, Brasil.

Heartworm disease is a health problem for dogs and cats, especially in tropical and subtropical coastal regions of the world. Some studies have compared the efficacy of the diagnostic techniques used to detect this parasitosis. Therefore, the aim of this study was to compare parasitological optical microscopy (POM), serological and molecular techniques for diagnosing canine heartworm infection. Read More

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http://dx.doi.org/10.1590/S1984-29612020009DOI Listing

Gastrointestinal nematode infections do not hinder the development of Simmental X Nellore crossbred calves raised with a nutritionally enhanced diet.

Rev Bras Parasitol Vet 2020 30;29(1):e015819. Epub 2020 Mar 30.

Departamento de Parasitologia, Instituto de Biociências, Universidade Estadual Paulista - UNESP, Botucatu, SP, Brasil.

An evaluation was made of the effect of anthelmintic treatments on the performance of Simmental X Nellore crossbred calves before and after weaning. To this end, the calves were divided into three groups: (1) treated monthly with a low efficacy anthelmintic drug, ivermectin; (2) treated monthly with a highly effective anthelmintic drug, albendazole; and (3) untreated control group. All the groups in this experiment showed an average fecal egg count of less than 400 eggs per gram (EPG), and no clinical signs of parasitic gastroenteritis. Read More

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http://dx.doi.org/10.1590/S1984-29612020006DOI Listing

Experimental parasite infection causes genome-wide changes in DNA methylation.

Mol Biol Evol 2020 Mar 30. Epub 2020 Mar 30.

School of Biological and Chemical Sciences, Queen Mary University of London, London, UK.

Parasites are arguably among the strongest drivers of natural selection, constraining hosts to evolve resistance and tolerance mechanisms. Although, the genetic basis of adaptation to parasite infection has been widely studied, little is known about how epigenetic changes contribute to parasite resistance and eventually, adaptation. Here, we investigated the role of host DNA methylation modifications to respond to parasite infections. Read More

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http://dx.doi.org/10.1093/molbev/msaa084DOI Listing

Presence of spp. and Other Zoonotic parasites Ova in Children's Playground in Karaman, Turkey

Turkiye Parazitol Derg 2020 Mar;44(1):17-20

University of Karamanoğlu Mehmetbey Faculty of Health Sciences, Department of Public Health, Karaman, Turkey

Objective: Human toxocariosis (HT) is a widespread and neglected parasitic disease around the world and it is caused by and , a common nematode found in dogs and cats. Childiren are caught to HT after ingestion of embriyonated spp. eggs via contaminated materials such as soil, hair and etc. Read More

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http://dx.doi.org/10.4274/tpd.galenos.2020.6256DOI Listing

MicroRNA Involvement in Signaling Pathways During Viral Infection.

Front Cell Dev Biol 2020 10;8:143. Epub 2020 Mar 10.

Department of Surgical Oncology, Institute of Oncology Prof. Dr. Alexandru Trestioreanu, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

The study of miRNAs started in 1993, when Lee et al. observed their involvement in the downregulation of a crucial protein known as LIN-14 in the nematode Since then, great progress has been made regarding research on microRNAs, which are now known to be involved in the regulation of various physiological and pathological processes in both animals and humans. One such example is represented by their interaction with various signaling pathways during viral infections. Read More

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http://dx.doi.org/10.3389/fcell.2020.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075948PMC

Economic benefits and costs of surgery for filarial hydrocele in Malawi.

PLoS Negl Trop Dis 2020 03 25;14(3):e0008003. Epub 2020 Mar 25.

Centre for Neglected Tropical Diseases, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Lymphatic filariasis (LF) is endemic in 72 countries of Africa, Asia, Oceania, and the Americas. An estimated 25 million men live with the disabling effects of filarial hydrocele. Hydrocele can be corrected with surgery with few complications. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094819PMC

The lungworm, Halocercus brasiliensis (Nematoda: Pseudaliidae), from Guiana Dolphins Sotalia guianensis from Brazil with Pathological Findings.

J Parasitol 2020 Apr;106(2):254-260

Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF), Av. Alberto Lamego, 2000, Parque Califórnia, Campos dos Goytacazes, Rio de Janeiro, 28013-602, Brazil.

The Guiana dolphin, Sotalia guianensis, is a small cetacean species found on the Atlantic coast of Central and South America from Honduras to Santa Catarina State, Brazil. The nematode Halocercus brasiliensis infects this cetacean, resulting in lung pathologies and death. The present study aimed to conduct a morphological and morphometric study of specimens of H. Read More

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http://dx.doi.org/10.1645/19-77DOI Listing

Early diagnosis of experimental Trichinella spiralis infection by nano-based enzyme-linked immunosorbent assay (nano-based ELISA).

Authors:
Maha M Gomaa

Exp Parasitol 2020 May 24;212:107867. Epub 2020 Feb 24.

Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. Electronic address:

Trichinellosis is a serious foodborne zoonotic disease. It is an important threat to public health all over the world. Although anti-Trichinella IgG detection is the most widely used method for diagnosis of trichinellosis, but there is an obvious window between clinical symptoms and positive serology. Read More

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http://dx.doi.org/10.1016/j.exppara.2020.107867DOI Listing

Prevalence of intestinal helminth parasites of stray dogs in Shendi area, Sudan

Ann Parasitol 2020 ;66(1):115–118

Faculty of Medical Technology, Prince of Songkla University, Hat Yai, Songkhla, Thailand

Three hundred and sixty fecal samples of stray dogs were collected between July and December 2018, from open grounds of Shendi city and two suburbs (Gulia and Musiab), River Nile State, Sudan, and were examined for helminthic infections. The results showed 43 (11.9%) of the samples were positive for at least one species of helminth. Read More

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January 2020

Strongyloides hyperinfection in a patient with solid malignant tumor a case report.

Indian J Public Health 2020 Jan-Mar;64(1):90-92

Clinical Microbiologist, Department of Laboratory Medicine, MIOT International, Chennai, Tamil Nadu, India.

Strongyloides stercoralis is unique among the nematodes, in which it completes its life cycle inside a single human host by causing autoinfection in the host, and it causes hyperinfection leading to persistent and fatal disseminated infections in immunocompromised hosts. The present case report is about strongyloidiasis fatal hyperinfection in a patient with malignant tumor of the tongue on radiotherapy treatment, to highlight the need for clinical suspicion of strongyloidiasis in an immunocompromised host. As per the Centers for Disease Control and Prevention, the mortality in strongyloides hyperinfection syndrome is alarmingly high, a case fatality rate that is almost 90%. Read More

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http://dx.doi.org/10.4103/ijph.IJPH_111_19DOI Listing

Pruritic Cutaneous Nematodiasis Caused by Avian Eyeworm Oxyspirura Larvae, Vietnam.

Emerg Infect Dis 2020 Apr;26(4):786-788

A 41-year-old man from Son La Province, Vietnam, sought care for disseminated prurigo-like skin lesions from which nematode larvae were emerging. We morphologically and molecularly identified the larvae as Oxyspirura sp. Our findings confirm this nematode species as a zoonotic pathogen for emerging disease. Read More

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http://dx.doi.org/10.3201/eid2604.191592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101080PMC

[Investigation on human hookworm infections in Anhui Province from 2014 to 2015].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jan;32(1):87-90

Anhui Provincial Institute of Parasitic Diseases, Hefei 230061, China.

Objective: To understand the current status and changing tendency of human hookworm infections in Anhui Province.

Methods: According to the unified national survey scheme, a total of 48 survey sites were sampled from 16 counties (cities) in 4 ecological regions of Anhui Province using a stratified cluster random sampling method from 2014 to 2015. The hookworm eggs were detected in the fecal samples from permanent residents at ages of over one year living in the survey sites using a modified Kato-Katz thick smear method, and the subjects'health knowledge and behaviors were investigated using questionnaire survey. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019242DOI Listing
January 2020

[Surveillance of soil-transmitted nematode infections in Zhenjiang City from 2006 to 2018].

Authors:
S S Li L Wang A H Li

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Oct;32(1):83-86

Zhenjiang Municipal Center for Disease Control and Prevention, Jiangsu Province, Zhenjiang 212004, China.

Objective: To understand the epidemic trend of soil-transmitted nematodiasis in Zhenjiang City from 2006 to 2018, so as to provide evidence for formulating targeted control measures.

Methods: The permanent residents at ages of 3 years and greater and the immigrants who had lived in Zhenjiang City for more than one year were selected as the study subjects. Fecal samples were collected, and the soil-transmitted nematode eggs were detected in fecal samples with the modified Kato-Katz technique (three smears from one stool sample), while the children at ages of 12 years and lower were tested for eggs using the adhesive cellophane-tape perianal swab method. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019137DOI Listing
October 2019

[Screening and bioinformatic analysis of trehalase in ].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Feb;32(1):60-68

Zunyi Medical University, Zunyi 563003, China.

Objective: To characterize the trehalase gene in through screening the annotated data of the genome, and to investigate the biological characteristics of the trehalase gene-coding protein.

Methods: The trehalase gene was screened from the genome and subjected to validation by using a PCR assay. The structural features of the coding protein were analyzed with bioinformatics tools, including hydrophobicity, transmembrane region, signal peptides, conserved domains, as well as the secondary and tertiary structures and the antigen epitope. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019133DOI Listing
February 2020

[National surveillance on infections among children at ages of 3 to 9 years in China from 2016 to 2018].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jan;32(1):54-59

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; WHO Collaborating Center for Tropical Diseases; Key Laboratory of Parasite and Vector Biology, National Health Commission, Shanghai 200025, China.

Objective: To understand the epidemic status of infections among children aged 3 to 9 years in China, so as to provide scientific basis for the formulation of the prevention and control strategies for enterobiasis.

Methods: The national surveillance of enterobiasis was performed in 736 national surveillance sites (counties) from 30 provinces (municipalities/autonomous regions) in China from 2016 to 2018. All surveillance sites were classified into parts according to the geographical directions, including the eastern, western, southern, northern and middle parts, and a township was randomly selected from each part. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019239DOI Listing
January 2020