59,024 results match your criteria Nematode Infections


J Zoo Wildl Med 2022 Jun;53(2):461-469

Zoo de Granby, Granby, QC J2G 5P3, Canada,

In this case series, clinical investigations were pursued during a infection in a lorikeet ( spp.) flock outbreak situation to better describe and document clinical presentations. In 11 lorikeets suspected to be infected with based on at least one abnormal finding on their physical examination (lethargy, feather-damaging behavior on the ventrum, weight loss, pale iris), the presence of five additional parameters was documented: anemia, relative eosinophilia, increased proventricular diameter-to-keel height ratio (PKR), proventricular barium filling defect, and positive fecal occult blood detection test. Read More

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J Zoo Wildl Med 2022 Jun;53(2):383-392

The Wilds, Cumberland, OH 43732, USA,

spp. are nematode parasites infecting many species, including domestic and wild ruminants in zoological and wildlife parks worldwide. These nematodes cause significant morbidity in giraffes () and other hoofstock. Read More

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Multiplex Serology for Measurement of IgG Antibodies Against Eleven Infectious Diseases in a National Serosurvey: Haiti 2014-2015.

Front Public Health 2022 9;10:897013. Epub 2022 Jun 9.

Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Background: Integrated surveillance for multiple diseases can be an efficient use of resources and advantageous for national public health programs. Detection of IgG antibodies typically indicates previous exposure to a pathogen but can potentially also serve to assess active infection status. Serological multiplex bead assays have recently been developed to simultaneously evaluate exposure to multiple antigenic targets. Read More

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Occurrence of Strongylid Nematode Parasites on Horse Farms in Berlin and Brandenburg, Germany, With High Seroprevalence of Infection.

Front Vet Sci 2022 10;9:892920. Epub 2022 Jun 10.

Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

The infection of horses with strongylid nematodes is highly prevalent, with multi-species infections being the rule. spp. and in particular are amongst the most pathogenic strongyle equine parasites. Read More

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Microplate bioassay to examine the effects of grapevine-isolated stilbenoids on survival of root knot nematodes.

BMC Res Notes 2022 Jun 25;15(1):220. Epub 2022 Jun 25.

Crop Diseases, Pests and Genetics Research Unit, USDA-ARS San Joaquin Valley Agricultural Sciences Center, 9611 S. Riverbend Ave, Parlier, CA, 93648, USA.

Objectives: Root knot nematodes can be major pests in vineyards and cause significant yield losses over time. Control involves the use of different resistant grapevine rootstocks, but it remains unclear the mechanisms that such rootstocks possess to limit root knot nematode infections. Defense-associated compounds called stilbenoids, a type of phenolic compound, are present in relatively substantial amounts in grapevine root tissues. Read More

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De novo transcriptome assembly and annotation of the third stage larvae of the zoonotic parasite Anisakis pegreffii.

BMC Res Notes 2022 Jun 25;15(1):223. Epub 2022 Jun 25.

Department of Ecological and Biological Sciences, Tuscia University, Viale dell'Università s/n, 01100, Viterbo, Italy.

Objectives: Anisakis pegreffii is a zoonotic parasite requiring marine organisms to complete its life-history. Human infection (anisakiasis) occurs when the third stage larvae (L3) are accidentally ingested with raw or undercooked infected fish or squids. A new de novo transcriptome of A. Read More

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Diagnostic challenge of Strongyloides stercoralis hyperinfection syndrome: a case report.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):79-81

Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Strongyloides stercoralis causes chronic, mostly asymptomatic infections but hyperinfection syndrome may occur in immunosuppressed patients, especially in those receiving corticosteroids. We report a case of S. stercoralis hyperinfection syndrome in a solid organ transplant recipient that occurred approximately 2. Read More

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Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.

Pharmaceuticals (Basel) 2022 May 27;15(6). Epub 2022 May 27.

Laboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron and protein, which can lead to severe anaemia and impaired cognitive development in children. Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains. Read More

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Aspartyl Protease Inhibitors as Anti-Filarial Drugs.

Pathogens 2022 Jun 18;11(6). Epub 2022 Jun 18.

Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode, and the endosymbiotic bacteria, . Read More

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Immunoinformatics Design and Assessment of a Multiepitope Antigen (OvMCBL02) for Onchocerciasis Diagnosis and Monitoring.

Diagnostics (Basel) 2022 Jun 11;12(6). Epub 2022 Jun 11.

Department of Biochemistry and Molecular Biology, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.

Onchocerciasis is a Neglected Tropical Disease that has a significant socioeconomic impact, especially in Sub-Saharan Africa. Numerous reports indicate that the Expanded Special Project for the Elimination of Neglected Tropical Diseases needs novel diagnostic tools before achieving its goal of successful elimination of onchocerciasis in Africa. The current diagnostic tests are either invasive, insensitive, or not applicable in the field and about 25% of persons infected cannot mount immune responses against the single antigen used in the only approved Ov-16 serological test. Read More

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Strongyloides Hyperinfection Syndrome among COVID-19 Patients Treated with Corticosteroids.

Emerg Infect Dis 2022 07;28(7):1531-1533

Widespread use of corticosteroids for COVID-19 treatment has led to Strongyloides reactivation and severe disease in patients from endemic areas. We describe a US patient with COVID-19 and Strongyloides hyperinfection syndrome and review other reported cases. Our findings highlight the need for Strongyloides screening and treatment in high-risk populations. Read More

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Corallopyronin A: antimicrobial discovery to preclinical development.

Nat Prod Rep 2022 Jun 22. Epub 2022 Jun 22.

German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany.

Covering: August 1984 up to January 2022Worldwide, increasing morbidity and mortality due to antibiotic-resistant microbial infections has been observed. Therefore, better prevention and control of infectious diseases, as well as appropriate use of approved antibacterial drugs are crucial. There is also an urgent need for the continuous development and supply of novel antibiotics. Read More

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The preparatory phase for ground larviciding implementation for chocerciasis control in the Meme River Basin in South West Cameroon: the COUNTDOWN Consortium alternative strategy implementation trial.

Parasit Vectors 2022 Jun 21;15(1):219. Epub 2022 Jun 21.

COUNTDOWN, Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Background: Onchocerciasis control using ivermectin alone has been achieved in some endemic savannah zones of Africa. In the forest regions, the co-endemicity with Loa loa has led to severe adverse events (SAEs) resulting in poor adherence of community members to ivermectin mass drug administration (MDA). This may jeopardize achieving the interruption of transmission of onchocerciasis. Read More

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Vector-borne pathogens in dogs from areas where leishmaniosis is endemic.

Vet Parasitol Reg Stud Reports 2022 Jul 9;32:100746. Epub 2022 Jun 9.

Department of Veterinary Medicine, University of Bari, Valenzano, Bari, Italy.

Many vector-borne pathogens (VBPs), including Ehrlichia canis and Dirofilaria immitis, may infect simultaneously dogs in areas where Leishmania infantum is endemic, especially in the tropics, where highly abundant arthropod vectors thrive. The aim of this study was to compare the frequency of simultaneous VBPs infection in Leishmania-positive and Leishmania-negative dogs. Animals enrolled in this study were divided in two groups (G1 and G2), G1 being comprised of L. Read More

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Identification of miRNAs of Strongyloides stercoralis L1 and iL3 larvae isolated from human stool.

Sci Rep 2022 Jun 15;12(1):9957. Epub 2022 Jun 15.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Verona, Italy.

Strongyloidiasis is a neglected tropical disease caused by the soil-transmitted nematode by Strongyloides stercoralis, that affects approximately 600 million people worldwide. In immunosuppressed individuals disseminated strongyloidiasis can rapidly lead to fatal outcomes. There is no gold standard for diagnosing strongyloidiasis, and infections are frequently misdiagnosed. Read More

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Anisakiasis erhvervet i Danmark.

Ugeskr Laeger 2022 Jun;184(23)

Kirurgisk Afdeling, Sjællands Universitetshospital, Køge.

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Laboratory breeding of two Phortica species (Diptera: Drosophilidae), vectors of the zoonotic eyeworm Thelazia callipaeda.

Parasit Vectors 2022 Jun 13;15(1):200. Epub 2022 Jun 13.

Dipartimento Di Sanità Pubblica E Malattie Infettive, Sapienza Università Di Roma, Rome, Italy.

Background: Some species of drosophilid flies belonging to the genus Phortica feed on ocular secretions of mammals, acting as biological vectors of the zoonotic eyeworm Thelazia callipaeda. This study describes an effective breeding protocol of Phortica variegata and Phortica oldenbergi in insectary conditions.

Methods: Alive gravid flies of P. Read More

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Integrated transmission assessment surveys (iTAS) of lymphatic filariasis and onchocerciasis in Cross River, Taraba and Yobe States, Nigeria.

Parasit Vectors 2022 Jun 13;15(1):201. Epub 2022 Jun 13.

Federal Ministry of Health, Abuja, Nigeria.

Background: Integrated transmission assessment surveys (iTAS) have been recommended for evaluation of the transmission of both lymphatic filariasis (LF) and onchocerciasis as the prevalence of both diseases moves toward their respective elimination targets in Nigeria. Therefore, we conducted an iTAS between May and December 2017 in five local government areas (LGAs), also known as implementation units (IUs), in states of Cross River, Taraba and Yobe in Nigeria.

Methods: The TAS comprised two phases: the Pre-iTAS and the iTAS itself. Read More

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Maternal gastrointestinal nematode infection enhances spatial memory of uninfected juvenile mouse pups.

Sci Rep 2022 Jun 13;12(1):9796. Epub 2022 Jun 13.

Institute of Parasitology, McGill University (Macdonald Campus), 21,111 Lakeshore Road, Ste-Anne de Bellevue, Quebec, H9X 3V9, Canada.

The developing brain is particularly vulnerable to factors including maternal infection during pregnancy. Establishment of neural networks critical for memory and cognition begins during the perinatal period, when Heligmosomoides bakeri, a gastrointestinal (GI) nematode restricted to the maternal mouse intestine, has been shown to upregulate expression of long-term potentiation genes in the young rodent pup brain. We explored the impact of maternal infection during pregnancy and early lactation on the spatial behavior of uninfected male and female juvenile mice. Read More

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The 'nuclear option' revisited: Confirmation of Ss-daf-12 function and therapeutic potential in Strongyloides stercoralis and other parasitic nematode infections.

Mol Biochem Parasitol 2022 Jun 11;250:111490. Epub 2022 Jun 11.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX USA.

Mechanisms governing morphogenesis and development of infectious third-stage larvae (L3i) of parasitic nematodes have been likened to those regulating dauer development in Caenorhabditis elegans. Dauer regulatory signal transduction comprises initial G protein-coupled receptor (GPCR) signaling in chemosensory neurons of the amphidial complex that regulates parallel insulin- and TGFβ-like signaling in the tissues. Insulin- and TGFβ-like signals converge to co-regulate steroid signaling through the nuclear receptor (NR) DAF-12. Read More

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Acute Encephalopathy in a Child with Threadworm Infection Treated with Mebendazole.

Ir Med J 2022 Apr 29;115(4):589. Epub 2022 Apr 29.

Paediatric Department, Midlands Regional Hospital Portlaoise.

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Statistical methods for linking geostatistical maps and transmission models: Application to lymphatic filariasis in East Africa.

Spat Spatiotemporal Epidemiol 2022 Jun 21;41:100391. Epub 2020 Nov 21.

Department of Statistics, University of Warwick, Coventry, UK; Zeeman Institute, University of Warwick, Coventry, UK. Electronic address:

Infectious diseases remain one of the major causes of human mortality and suffering. Mathematical models have been established as an important tool for capturing the features that drive the spread of the disease, predicting the progression of an epidemic and hence guiding the development of strategies to control it. Another important area of epidemiological interest is the development of geostatistical methods for the analysis of data from spatially referenced prevalence surveys. Read More

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Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection.

Mucosal Immunol 2022 Jun 11. Epub 2022 Jun 11.

Institute of Immunology, Centre for Infection Medicine, Freie Universität Berlin, Berlin, Germany.

The efficient induction of type 2 immune responses is central to the control of helminth infections. Previous studies demonstrated that strong Th1 responses driven by intracellular pathogens as well as a bias for type 1 activity in senescent mice impedes the generation of Th2 responses and the control of intestinal nematode infections. Here, we show that the spontaneous differentiation of Th1 cells and their expansion with age restrains type 2 immunity to infection with the small intestinal nematode H. Read More

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National surveillance of hookworm disease in China: A population study.

PLoS Negl Trop Dis 2022 06 9;16(6):e0010405. Epub 2022 Jun 9.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.

Background: Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great.

Methods: The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019. Read More

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Do water shortages increase gastrointestinal nematode loads in Nguni does?

Trop Anim Health Prod 2022 Jun 9;54(4):208. Epub 2022 Jun 9.

Animal and Poultry Science, School of Agricultural, Earth and Environmental Sciences, University of KwaZulu-Natal, P Bag X01 Scottsville 3209, Pietermaritzburg, South Africa.

Objective: The objective of the study was to assess the effects of water deprivation on the burden of gastrointestinal nematodes in Nguni does.

Methods: A survey was piloted on goat keepers in households where water was scarce (n = 143) and where it was available throughout the year (n = 142). In a controlled experiment, feed intake (ADFI), body condition score (BCS), FAMACHA score, packed cell volume (PCV) and faecal egg counts (FEC) were determined in does deprived of water for 24 and 48 h. Read More

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Study on Gastrointestinal Nematodes of Equines in and around Bekoji, South Eastern Ethiopia.

J Parasitol Res 2022 30;2022:8210160. Epub 2022 May 30.

School of Veterinary Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Parasitic infections can cause a variety of respiratory, intestinal, and other problems in horses, as well as contribute to some performance issues. A cross-sectional study was undertaken in and around Bekoji, South Eastern Ethiopia, from November 2020 to June 2021 to identify species and evaluate the prevalence of gastrointestinal parasites in donkeys and horses, using direct fecal smear, floatation methods, and larval cultures. In this study, the overall prevalence of gastrointestinal nematode parasites was 94. Read More

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Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling.

Parasit Vectors 2022 Jun 8;15(1):197. Epub 2022 Jun 8.

Instituto de Investigaciones de Enfermedades Tropicales (IIET), Sede Regional Orán Universidad Nacional de Salta, Salta, Argentina.

Background: The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections on a national and sub-national scale would allow for a better allocation of resources. Read More

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Anisakiasis: Imaging findings.

Radiologia (Engl Ed) 2022 May-Jun;64(3):245-255

Servicio de Radiodiagnóstico, Hospital Universitario Basurto, Bilbao, Bizkaia, Spain.

Objective: To review the main findings for anisakiasis in the different imaging tests that can be used to diagnose it, based on studies done at our center.

Conclusion: The presence of Anisakis species in food consumed in Western countries is becoming more common. Patients with anisakiasis present with acute abdomen; there are no specific clinical signs or laboratory findings. Read More

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Seropositivity of main vector-borne pathogens in dogs across Europe.

Parasit Vectors 2022 Jun 6;15(1):189. Epub 2022 Jun 6.

Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Background: Canine vector-borne disease (CVBD) has been an area of increasing interest in Europe over the last few decades, and there have been changes in the prevalence and distribution of many of these diseases. Monitoring CVBD infections in Europe is often done by individual countries, but aggregated data for the European countries are helpful to understand the distribution of CVBDs.

Methods: We used an extensive retrospective database of results from point-of-care rapid enzyme-linked immunosorbent assay (ELISA) tests on dogs across Europe to identify distribution and seropositivity in animals tested for selected CVBDs (Anaplasma spp. Read More

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Implementation of a targeted treatment strategy for the sustainable control of infections in laying hens.

Vet Rec Open 2022 Dec 30;9(1):e37. Epub 2022 May 30.

Department of Biomedical Sciences and Veterinary Public Health, Section for Parasitology Swedish University of Agricultural Sciences (SLU) Uppsala Sweden.

Background: is a widespread problem in cage-free egg production. Sustainable control of nematode infections is a key component in this sector. This study investigates the effect of a treatment strategy against , aiming to propose a guideline for anthelmintic use on commercial poultry farms. Read More

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December 2022