54,495 results match your criteria Nematode Infections


Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

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http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019

Intestinal Nematode Infection Exacerbates Experimental Visceral Leishmaniasis.

Parasite Immunol 2019 Feb 11:e12618. Epub 2019 Feb 11.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.

Leishmania donovani exposure often results in subclinical infection in immunocompetent individuals, and the factors dictating development of visceral leishmaniasis (VL) are not known. Infection with intestinal worms skew immunity towards type 2 and regulatory responses, thereby theoretically increases susceptibility to intracellular infections controlled by type 1 responses. Here we tested how chronic infection with the intestinal nematode Heligmosomoides polygyrus affected immunity to a secondary infection with L. Read More

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http://dx.doi.org/10.1111/pim.12618DOI Listing
February 2019

Ascaris suum infection was associated with a worm-independent reduction in microbial diversity and altered metabolic potential in the porcine gut microbiome.

Int J Parasitol 2019 Feb 8. Epub 2019 Feb 8.

United States Department of Agriculture, Agricultural Research Service, Animal Parasitic Disease Laboratory, Beltsville, MD, USA. Electronic address:

The effect of infection of pigs with Ascaris suum on the microbial composition in the proximal colon and fecal matter was investigated using 16S rRNA gene sequencing. The infection significantly decreased various microbial diversity indices including Chao1 richness, but the effect on Chao1 in the colon luminal contents was worm burden-independent. The abundance of 49 genera present in colon contents, such as Prevotella and Faecalibacterium, and 179 operational taxonomic units was significantly changed as a result of infection. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.10.007DOI Listing
February 2019

Seroprevalence, biogeographic distribution and risk factors for Aelurostrongylus abstrusus infections in Swiss cats.

Vet Parasitol 2019 Feb 4;266:27-33. Epub 2019 Jan 4.

Institute of Parasitology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

The metastrongyloid nematode Aelurostrongylus abstrusus is a worldwide occurring feline lungworm. The spectrum of clinical signs in infected cats ranges from mild (e.g. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.013DOI Listing
February 2019

Homeostasis in the soybean microRNA396-GRF network is essential for productive soybean cyst nematode infections.

J Exp Bot 2019 Jan 30. Epub 2019 Jan 30.

Department of Plant Pathology and Microbiology, Iowa State University, Ames, Iowa, U.S.A.

Heterodera glycines, the soybean cyst nematode, penetrates soybean roots and migrates to the vascular cylinder where it forms a feeding site called the syncytium. MicroRNA396 (miR396) targets Growth-Regulating Factors (GRFs), and the miR396-GRF1/3 module is a master regulator of syncytium development in model cyst nematode Heterodera schachtii infection of Arabidopsis. Here, we investigated whether this regulatory system operates similarly in soybean roots and is likewise important for H. Read More

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http://dx.doi.org/10.1093/jxb/erz022DOI Listing
January 2019

Ozone treatments activate defence responses against Meloidogyne incognita and Tomato spotted wilt virus in tomato.

Pest Manag Sci 2019 Jan 30. Epub 2019 Jan 30.

Institute for Sustainable Plant Protection, CNR, via G. Amendola 122/d, 70126, Bari, Italy.

Background: Ozonated water (O wat) soil drench and/or foliar spray applications, were evaluated for their potential to control the root-knot nematode Meloidogyne incognita (RKN) and the airborne pathogen Tomato spotted wilt virus (TSWV) in tomato. We investigated how O wat modulates the SA/JA/ET signalling network in the host, locally and systemically, to induce resistance to nematode and virus.

Results: The application as soil drench was effective in reducing the number of galls and egg masses, but did not reduce the incidence and severity of TSWV infection. Read More

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http://dx.doi.org/10.1002/ps.5362DOI Listing
January 2019

Human oral dirofilariasis.

Trop Parasitol 2018 Jul-Dec;8(2):110-113. Epub 2018 Dec 27.

Department of Oral and Maxillofacial Pathology, Goa Dental College and Hospital, Bambolim, Goa, India.

Zoonotic filarial infections particularly dirofilariasis have been reported worldwide. The route of transmission to human beings is vector-borne through mosquitoes. Increased mosquito activity subsequent to global warming has influenced the transmission of dirofilarial infection in many geographic regions, including Asia. Read More

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http://dx.doi.org/10.4103/tp.TP_49_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329264PMC
December 2018

Prevalence of Borrelia burgdorferi, Anaplasma spp., Ehrlichia spp. and Dirofilaria immitis in Canadian dogs, 2008 to 2015: a repeat cross-sectional study.

Parasit Vectors 2019 Jan 28;12(1):64. Epub 2019 Jan 28.

University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

Background: Vector-borne pathogens are emerging concerns in multiple regions of Canada. Determining regional prevalence of canine vector-borne pathogens and documenting change will improve clinician awareness, enable targeted prevention, enhance diagnosis and ideally reduce the risk of disease. Study objectives were to: (i) estimate the prevalence of positive canine vector-borne test results from samples submitted in Canada; (ii) assess change in prevalence over time, from baseline (2008) to 2015; and (iii) estimate the prevalence of pathogen co-infections. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350403PMC
January 2019
5 Reads

Patent infections with soil-transmitted helminths and Schistosoma mansoni are not associated with increased prevalence of antibodies to the Onchocerca volvulus peptide epitopes OvMP-1 and OvMP-23.

Parasit Vectors 2019 Jan 28;12(1):63. Epub 2019 Jan 28.

Janssen Diagnostics, Janssen R&D, Turnhoutseweg 30, 2340, Beerse, Belgium.

Background: Ov16 serology is considered a reference method for Onchocerca volvulus epidemiological mapping. Given the suboptimal sensitivity of this test and the fact that seroconversion takes more than a year after infection, additional serological tests might be needed to guide onchocerciasis elimination programmes. Recently, two linear epitopes encoded in OvMP-1 and OvMP-23 peptides were introduced as serological markers, but the observed antibody cross-reactivity in samples originating from Onchocerca volvulus non-endemic areas required further investigation. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-019-3308-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350367PMC
January 2019
8 Reads

Fitness costs of phoretic nematodes in the burying beetle, .

Ecol Evol 2019 Jan 19;9(1):26-35. Epub 2018 Dec 19.

Institute of Biology Leiden University Leiden The Netherlands.

is a social beetle that rears its offspring on decomposing carrion. Wild beetles are frequently associated with two types of macrobial symbionts, mites, and nematodes. Although these organisms are believed to be phoretic commensals that harmlessly use beetles as a means of transfer between carcasses, the role of these symbionts on fitness is poorly understood. Read More

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http://dx.doi.org/10.1002/ece3.4570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342123PMC
January 2019
1 Read

A longitudinal assessment of host-microbe-parasite interactions resolves the zebrafish gut microbiome's link to Pseudocapillaria tomentosa infection and pathology.

Microbiome 2019 Jan 24;7(1):10. Epub 2019 Jan 24.

Department of Microbiology, Oregon State University, Corvallis, OR, 97330, USA.

Background: Helminth parasites represent a significant threat to the health of human and animal populations, and there is a growing need for tools to treat, diagnose, and prevent these infections. Recent work has turned to the gut microbiome as a utilitarian agent in this regard; components of the microbiome may interact with parasites to influence their success in the gut, meaning that the microbiome may encode new anthelmintic drugs. Moreover, parasite infections may restructure the microbiome's composition in consistent ways, implying that the microbiome may be useful for diagnosing infection. Read More

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http://dx.doi.org/10.1186/s40168-019-0622-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346533PMC
January 2019
1 Read

Transcriptome analysis unraveled potential mechanisms of resistance to Haemonchus contortus infection in Merino sheep populations bred for parasite resistance.

Vet Res 2019 Jan 24;50(1). Epub 2019 Jan 24.

United States Department of Agriculture, Agriculture Research Service, Animal Genomics and Improvement Laboratory, Beltsville, MD, USA.

Haemonchus contortus is one of the most pathogenic gastrointestinal nematodes in small ruminants. To understand molecular mechanisms underlying host resistance to this parasite, we used RNA-sequencing technology to compare the transcriptomic response of the abomasal tissue, the site of the host-parasite interaction, of Merino sheep bred to be either genetically resistant or susceptible to H. contortus infection. Read More

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http://dx.doi.org/10.1186/s13567-019-0622-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345051PMC
January 2019
3 Reads
2.815 Impact Factor

Mice as paratenic hosts of Aelurostrongylus abstrusus.

Parasit Vectors 2019 Jan 22;12(1):49. Epub 2019 Jan 22.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, Str. prov. per Casamassima km 3, 70010, Valenzano (Bari), Italy.

Background: Several species of nematodes included in the superfamily Metastrongyloidea are recognized agents of parasitic infections in felines. Aelurostrongylus abstrusus is the most prevalent species affecting the respiratory system of domestic cats. The route of infection in cats is supposed to be through ingestion of gastropod intermediate or paratenic hosts. Read More

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http://dx.doi.org/10.1186/s13071-019-3293-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343334PMC
January 2019
1 Read

Epidemiology of Strongyloides stercoralis infection in Bolivian patients at high risk of complications.

PLoS Negl Trop Dis 2019 01 17;13(1):e0007028. Epub 2019 Jan 17.

Division of Tropical and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Background: Strongyloidiasis can be fatal in immunocompromised patients, but few epidemiological studies investigated the burden of this neglected tropical disease among these populations, particularly in low- and middle-income countries such as Bolivia. This study aimed to fill in this gap by estimating prevalence rate and risk factors associated with strongyloidiasis among patients at high risk of complications.

Methods: A cross-sectional study was carried out in Santa Cruz (elevation 400 meters, tropical climate) and Cochabamba (elevation 2,500 meters, temperate climate), among patients with cancer, HIV infection and rheumatic or hematologic disease, using four coproparasitological techniques and one serological (ELISA) test. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007028
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http://dx.doi.org/10.1371/journal.pntd.0007028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353209PMC
January 2019
6 Reads

Flubendazole as a macrofilaricide: History and background.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006436. Epub 2019 Jan 16.

Johnson & Johnson Global Public Health, Janssen Research and Development, LLC., New Brunswick, New Jersey, United States of America.

Benzimidazole anthelmintics have long been employed for the control of soil-transmitted helminth infections. Flubendazole (FBZ) was approved in 1980 for the treatment of gastrointestinal nematode infections in both veterinary and human medicine. It has also long been known that parenteral administration of FBZ can lead to high macrofilaricidal efficacy in a variety of preclinical models and in humans. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334891PMC
January 2019
5 Reads

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006320. Epub 2019 Jan 16.

Institute for Medical Microbiology, Immunology and Parasitology, University Hospital of Bonn, Bonn, Germany.

Flubendazole (FBZ) is highly efficacious against filarial nematodes after parenteral administration and presents a promising macrofilaricidal drug candidate for the elimination of onchocerciasis and other filariae. In the present study the efficacy of a newly developed bioavailable amorphous solid dispersion (ASD) oral formulation of FBZ was investigated in the Litomosoides sigmodontis jird model. FBZ was administered to chronically infected, microfilariae-positive jirds by single (40mg/kg), repeated (2, 6 or 15mg/kg for 5 or 10 days) oral (OR) doses or single subcutaneous (SC) injections (2 or 10mg/kg). Read More

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http://dx.doi.org/10.1371/journal.pntd.0006320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334906PMC
January 2019
2 Reads

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006787. Epub 2019 Jan 16.

Dept. of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America.

River blindness and lymphatic filariasis are two filarial diseases that globally affect millions of people mostly in impoverished countries. Current mass drug administration programs rely on drugs that primarily target the microfilariae, which are released from adult female worms. The female worms can live for several years, releasing millions of microfilariae throughout the course of infection. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334909PMC
January 2019
1 Read

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

PLoS Negl Trop Dis 2019 01 16;13(1):e0006356. Epub 2019 Jan 16.

Department of Parasitology and Research Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.

The Onchocerca ochengi adult implant and Brugia malayi microfilariemic Severe-Combined Immunodeficient (SCID) mouse models are validated screens to measure macrofilaricidal and microfilaricidal activities of candidate onchocerciasis drugs. The purpose of this study was to assess whether 5 daily sub-cutaneous (s.c. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334903PMC
January 2019
1 Read

Entomological assessment of the transmission following recrudescence of onchocerciasis in the Comoé Valley, Burkina Faso.

Parasit Vectors 2019 Jan 15;12(1):34. Epub 2019 Jan 15.

Ministère de l'Enseignement Supérieur, de la Recherche Scientifique et de l'Innovation, Institut de Recherche en Sciences de la Santé (IRSS), Direction Régionale de l'Ouest, BP 545, Bobo Dioulasso 01, Burkina Faso.

Background: Onchocerciasis, or river blindness, is a dermal filariasis caused by infection with the nematode parasite Onchocerca volvulus, transmitted to humans through the bites of blackflies of the genus Simulium. Despite the decade-long West African Regional Programme for the Elimination of Onchocerciasis, involving the mass administration of ivermectin to populations in endemic areas, recrudescence has occurred. An example is in the Cascades Region of south-west Burkina Faso where the resumption of transmission had resulted in infection prevalences of up to 70% in some villages. Read More

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http://dx.doi.org/10.1186/s13071-019-3290-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332526PMC
January 2019
1 Read

Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast.

Parasite 2019 15;26. Epub 2019 Jan 15.

Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov First Moscow State Medical University, Moscow 119435, Russia.

Dirofilariasis is endemic in Russia, as well as in many other European countries. The aim of this study was to assess the ability of mosquitoes to transfer Dirofilaria immitis and Dirofilaria repens in regions with temperate and subtropical climates. The possible impact of the symbiotic bacterium Wolbachia on Dirofilaria transmission was also investigated. Read More

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https://www.parasite-journal.org/10.1051/parasite/2019002
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http://dx.doi.org/10.1051/parasite/2019002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333102PMC
January 2019
6 Reads

Prevention of canine ocular thelaziosis (Thelazia callipaeda) with a combination of milbemycin oxime and afoxolaner (Nexgard Spectra) in endemic areas in France and Spain.

Parasite 2019 15;26. Epub 2019 Jan 15.

Boehringer Ingelheim Animal Health, 29 avenue Tony Garnier, 69007 Lyon, France.

In the past decade, canine thelaziosis due to Thelazia callipaeda has been diagnosed in an increasing number of European countries, with endemic areas being identified. A multi-center field trial was conducted in endemic areas in France and Spain to evaluate the efficacy of monthly administrations of the oral milbemycin oxime/afoxolaner combination (NexGard Spectra) for the prevention of T. callipaeda infection in at-risk dogs. Read More

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http://dx.doi.org/10.1051/parasite/2019001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333103PMC
January 2019
1 Read

The central adaptor molecule TRIF influences L. sigmodontis worm development.

Parasitol Res 2019 Feb 15;118(2):539-549. Epub 2019 Jan 15.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Sigmund Freud Str. 25, 53127, Bonn, Germany.

Worldwide approximately 68 million people are infected with lymphatic filariasis (Lf), provoked by Wuchereria bancrofti, Brugia malayi and Brugia timori. This disease can lead to massive swelling of the limbs (elephantiasis) and disfigurement of the male genitalia (hydrocele). Filarial induced immune regulation is characterised by dominant type 2 helper T cell and regulatory immune responses. Read More

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http://dx.doi.org/10.1007/s00436-018-6159-1DOI Listing
February 2019
1 Read

Field evidence for association between increased gastrointestinal nematode burden and subclinical mastitis in dairy sheep.

Vet Parasitol 2019 Jan 7;265:56-62. Epub 2018 Dec 7.

Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece. Electronic address:

The objective of the present study was to study, under field conditions, potential associations between gastrointestinal nematode parasitism and subclinical mastitis in ewes during the lactation period. Faecal and milk samples were collected from 240 ewes in 16 farms, for parasitological and bacteriological plus cytological examination, respectively. In the population sampled, prevalence of gastrointestinal nematode infection was 63. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.010DOI Listing
January 2019
2 Reads

Emergence and the spread of the F200Y benzimidazole resistance mutation in Haemonchus contortus and Haemonchus placei from buffalo and cattle.

Vet Parasitol 2019 Jan 11;265:48-54. Epub 2018 Dec 11.

University of Edinburgh, The Roslin Institute, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, UK. Electronic address:

Benzimidazoles have been intensively (for over 40 years) used in the livestock sector, particularly in small ruminants. This has been led to the widespread emergence of resistance in a number of small ruminant parasite species, especially Haemonchus contortus. In many countries benzimidazole resistance has severely compromised the control of H. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03044017183038
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http://dx.doi.org/10.1016/j.vetpar.2018.12.001DOI Listing
January 2019
5 Reads

Impact of gastrointestinal parasitism on dry matter intake and live weight gain of lambs: A meta-analysis to estimate the metabolic cost of gastrointestinal nematodes.

Vet Parasitol 2019 Jan 30;265:1-6. Epub 2018 Nov 30.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Km 15.5 Carretera Mérida-Xmatkuil, 97315 Mérida, Yucatán, Mexico. Electronic address:

This study aimed to estimate the effect of gastrointestinal nematodes (GIN) on the productive performance assessed by the live-weight change (LWC) of lambs, and the metabolic cost associated with parasitism by means of a meta-analysis. Data used in the meta-analyses were obtained from twenty papers selected using the following criteria: (a) lambs with (I) and without (NI) GIN; (b) lambs fed ad libitum; (c) LWC data; (d) feed consumption data; and (e) chemical composition of diets. The effect of diet composition (crude protein [CP] and metabolizable energy [ME]) on dry matter intake (DMI), and the effect of composition and nutrient intake (DMI and CP intake [CPI]) and ME intake (MEI) on LWC was evaluated using respective regression analyses. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.008DOI Listing
January 2019
1 Read

Effectiveness of the spot-on combination of moxidectin and imidacloprid (Advocate®) in the treatment of ocular thelaziosis by Thelazia callipaeda in naturally infected cats.

Parasit Vectors 2019 Jan 11;12(1):25. Epub 2019 Jan 11.

Dipartimento di Medicina Veterinaria, Università degli Studi di Bari, 70010, Valenzano, Italy.

Background: The present study evaluated the therapeutic effectiveness of moxidectin 1.0% (w/v) and imidacloprid 10% (w/v) (Advocate® spot-on solution for cats, Bayer Animal Health) against natural infections with the eyeworm Thelazia callipaeda in cats. This study was conducted as a GCP, negative-controlled, blinded and randomised field study in privately owned cats living in an area in southern Italy where T. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3262-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329153PMC
January 2019
4 Reads

Morphological and Molecular Characterization of Toxocara tanuki (Nematoda: Ascaridae) from Korean Raccoon Dog, Nyctereutes procyonoides koreensis.

Korean J Parasitol 2018 Dec 31;56(6):567-575. Epub 2018 Dec 31.

College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.

Present study was performed to describe the morphological and molecular characterization of Toxocara tanuki (Nematoda: Ascaridae) from Korean raccoon dog, Nyctereutes procyonoides koreensis, naturally infected in the Republic of Korea (Korea). Juvenile and adult worms of T. tanuki were recovered in 5 out of 10 raccoon dogs examined and the larval worms were detected in 15 out of 20 muscle samples (75%). Read More

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http://dx.doi.org/10.3347/kjp.2018.56.6.567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327194PMC
December 2018

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.

PLoS Negl Trop Dis 2019 01 10;13(1):e0007086. Epub 2019 Jan 10.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Introduction: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929PMC
January 2019
5 Reads

Secretome analysis of Strongyloides venezuelensis parasitic stages reveals that soluble and insoluble proteins are involved in its parasitism.

Parasit Vectors 2019 Jan 9;12(1):21. Epub 2019 Jan 9.

Division of Parasitology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.

Background: Parasites excrete and secrete a wide range of molecules that act as the primary interface with their hosts and play critical roles in establishing parasitism during different stages of infection. Strongyloides venezuelensis is a gastrointestinal parasite of rats that is widely used as a laboratory model and is known to produce both soluble and insoluble (adhesive) secretions during its parasitic stages. However, little is known about the constituents of these secretions. Read More

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http://dx.doi.org/10.1186/s13071-018-3266-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327390PMC
January 2019
1 Read

Effect of flubendazole on developing stages of Loa loa in vitro and in vivo: a new approach for screening filaricidal agents.

Parasit Vectors 2019 Jan 8;12(1):14. Epub 2019 Jan 8.

Parasites and Vectors Biology Research Unit (PAVBRU), Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon.

Background: Loiasis, an often-neglected tropical disease, is a threat to the success of lymphatic filariasis and onchocerciasis elimination programmes in rainforest areas of the central and western Africa. Its control and even its elimination might be possible through the use of a safe macrofilaricide, a prophylactic drug, or perhaps a vaccine. This present study evaluated the effect of flubendazole (FLBZ) on the development of Loa loa L3 in vitro and in vivo. Read More

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http://dx.doi.org/10.1186/s13071-018-3282-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323797PMC
January 2019
7 Reads
3.430 Impact Factor

Experimental infection with Anguillicola crassus alters immune gene expression in both spleen and head kidney of the European eel (Anguilla anguilla).

Mar Genomics 2019 Jan 4. Epub 2019 Jan 4.

Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Müggelseedamm 301/310, 12587 Berlin, Germany; Berlin Center for Genomics in Biodiversity Research, Königin-Luise-Strasse 6-8, 14195 Berlin, Germany; Freie Universität Berlin, Königin-Luise-Strasse 1-3, 14195 Berlin, Germany. Electronic address:

Invasive parasites have been implicated in the declines of several freshwater species. The swim bladder nematode Anguillicola crassus was introduced into Europe in the 1980s and is considered a threat to the European eel (Anguilla anguilla). Infection affects stress resistance and swimming behaviour. Read More

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http://dx.doi.org/10.1016/j.margen.2018.12.002DOI Listing
January 2019

Tannin-rich sainfoin pellet supplementation reduces fat volatile indoles content and delays digestive parasitism in lambs grazing alfalfa.

Animal 2019 Jan 7:1-8. Epub 2019 Jan 7.

1Université d'Auvergne,INRA,Vetagro Sup,UMR Herbivores,63122 St-Genès-Champanelle,France.

Lambs grazing alfalfa or white clover are prone to flavour taint which can be an impediment to consumer acceptance. Here we investigated whether condensed tannin (CT)-rich sainfoin pellet supplementation of lambs grazing alfalfa influences meat sensory quality. Using three groups of 18 male Romane weaned lambs, we compared three feeding regimes: alfalfa grazing (AF), alfalfa grazing + daily supplementation with CT-rich sainfoin pellets (15 g dry matter (DM)/kg live weight, AS) and stall feeding with concentrate and grass hay indoors (SI). Read More

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http://dx.doi.org/10.1017/S1751731118003543DOI Listing
January 2019

Elimination within reach: A cross-sectional study highlighting the factors that contribute to persistent lymphatic filariasis in eight communities in rural Ghana.

PLoS Negl Trop Dis 2019 01 4;13(1):e0006994. Epub 2019 Jan 4.

Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.

Background: Despite the progress achieved in scaling-up mass drug administration (MDA) for lymphatic filariasis (LF) in Ghana, communities with persistent LF still exist even after 10 years of community treatment. To understand the reasons for persistence, we conducted a study to assess the status of disease elimination and understand the adherence to interventions including MDA and insecticide treated nets.

Methodology And Principal Findings: We conducted a parasitological and epidemiological cross-sectional study in adults from eight villages still under MDA in the Northern Region savannah and the coastal Western Region of the country. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342320PMC
January 2019
1 Read

Epidemiology and genetic diversity of Anaplasma ovis in goats in Corsica, France.

Parasit Vectors 2019 Jan 3;12(1). Epub 2019 Jan 3.

BIOEPAR, INRA, Oniris, 44307, Nantes, France.

Background: Anaplasma ovis is a major cause of small ruminant anaplasmosis, a tick-borne disease mainly affecting small ruminants in tropical and subtropical regions of the world. Due to health and production problems in dairy goat flocks in Corsica, France, and the demonstration of A. ovis infection in some animals, an extensive survey was conducted in the island in spring 2016. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3269-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318933PMC
January 2019
1 Read

TRANSMISSION OF PTERYGODERMATITES NYCTICEBI IN A COLONY OF GOELDI'S MONKEYS ( CALLIMICO GOELDII) AND EVALUATION OF TREATMENT AND CONTROL.

J Zoo Wildl Med 2018 Dec;49(4):893-901

Over a 2-yr period, four Goeldi's monkeys ( Callimico goeldii) died in a private zoo due to infections with the spirurid nematode Pterygodermatites nycticebi. Therapeutic measures with different anthelmintics were not successful. Due to the severe consequences caused by these infections, different actions were initiated, including sanitation measures and controlling of potential intermediate hosts (coprophagous arthropods). Read More

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http://dx.doi.org/10.1638/2017-0177.1DOI Listing
December 2018

Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study.

PLoS Negl Trop Dis 2018 12 27;12(12):e0007002. Epub 2018 Dec 27.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston MA, United States of America.

Background: Neglected tropical diseases (NTDs) account for a large disease burden in sub-Saharan Africa. While the general cost-effectiveness of NTD interventions to improve health outcomes has been assessed, few studies have also accounted for the financial and education gains of investing in NTD control.

Methods: We built on extended cost-effectiveness analysis (ECEA) methods to assess the health gains (e. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007002
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http://dx.doi.org/10.1371/journal.pntd.0007002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307713PMC
December 2018
11 Reads

Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination.

Parasit Vectors 2018 Dec 27;11(1):672. Epub 2018 Dec 27.

Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.

Background: The global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. Read More

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http://dx.doi.org/10.1186/s13071-018-3260-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307201PMC
December 2018
1 Read
3.430 Impact Factor

Efficacy and side effects of doxycycline versus minocycline in the three-dose melarsomine canine adulticidal heartworm treatment protocol.

Parasit Vectors 2018 Dec 27;11(1):671. Epub 2018 Dec 27.

College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Background: The American Heartworm Society currently recommends the use of a monthly macrocyclic lactone, a 28-day course of 10 mg/kg doxycycline BID, and the 3-dose protocol of melarsomine dihydrochloride for the treatment of canine heartworm disease. Doxycycline is necessary for the reduction of the bacterium Wolbachia, found in all heartworm life-stages. Previous price increases and decreasing availability prompted us to evaluate alternative tetracycline antibiotics, i. Read More

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http://dx.doi.org/10.1186/s13071-018-3264-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307258PMC
December 2018

Mapping of the complement C1q binding site on Trichinella spiralis paramyosin.

Parasit Vectors 2018 Dec 27;11(1):666. Epub 2018 Dec 27.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Background: Trichinella spiralis is a tissue-dwelling parasite has developed the ability to evade the host immune attack to establish parasitism in a host. One of the strategies evolved by the nematode is to produce proteins that immunomodulate the host immune system. TsPmy is a paramyosin secreted by T. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3258-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307294PMC
December 2018
7 Reads

Occurrence of Trichinella spp. in rats on pig farms.

Ann Agric Environ Med 2018 Dec 29;25(4):698-700. Epub 2018 Nov 29.

National Veterinary Research Institute, Puławy, Poland.

Introduction: The highest risk of trichinellosis for human is considered in eating meat products containing live larvae, mostly from wild boars or pigs. Spreading of Trichinella spp. may occur in various ways, one of which is transmission by vectors. Read More

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http://www.journalssystem.com/aaem/The-occurrence-of-Trichin
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http://dx.doi.org/10.26444/aaem/99555DOI Listing
December 2018
9 Reads

Association of polymorphisms of the β-defensin 1 gene with nematode and protozoan infection traits in goat.

Parasite Immunol 2018 Dec 24:e12613. Epub 2018 Dec 24.

Health and Animal Production Institute, Federal Rural University of Amazon, Belém, Brazil.

This study's purpose was to identify polymorphisms (SNP) in the goat β-defensin 1 gene and to associate these SNPs with traits related to nematodean and protozoan infections in Anglo-Nubian goats from semiarid region of Brazil. A total of 184 animals were used for DNA extraction, PCR and DNA automatic sequencing. The association analyses included the fixed effects of animal age, bloodline and genotype of the SNP marker in the statistical model. Read More

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http://dx.doi.org/10.1111/pim.12613DOI Listing
December 2018
1 Read

Static Immersion and Injection Methods for Live Cell Imaging of Foodborne Pathogen Infections in Zebrafish Larvae.

Methods Mol Biol 2019 ;1918:183-190

Laboratorio de Microbiología de Sistemas, Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

Important features of host-pathogen interactions have been discovered using nonmammalian hosts. Therefore, model organisms such as the nematode Caenorhabditis elegans, the social amoeba Dictyostelium discoideum, and zebrafish ( Danio rerio ) have been increasingly used for studying bacterial pathogenesis in vivo. These host models are amenable for live cell imaging studies, which can also benefit from online resources and databases ( Dictybase. Read More

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http://dx.doi.org/10.1007/978-1-4939-9000-9_15DOI Listing
January 2019
1 Read

Link to Alzheimer's seen in nodding syndrome.

Authors:
Laura Spinney

Science 2018 12;362(6421):1341

Laura Spinney is a journalist in Paris.

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http://dx.doi.org/10.1126/science.362.6421.1341DOI Listing
December 2018

Achieving the endgame: Integrated NTD case searches.

PLoS Negl Trop Dis 2018 12 20;12(12):e0006623. Epub 2018 Dec 20.

The Carter Center, Atlanta, Georgia, United States of America.

Trachoma and Guinea Worm Disease (GWD) are neglected tropical diseases (NTD) slated for elimination as a public health problem and eradication respectively by the World Health Organization. As these programs wind down, uncovering the last cases becomes an urgent priority. In 2010, Ghana Health Services, along with The Carter Center, Sightsavers, and other partners, conducted integrated case searches for both GWD and the last stage of trachoma disease, trachomatous trichiasis (TT), as well as providing surgical treatment for TT to meet elimination (and eradication targets). Read More

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http://dx.plos.org/10.1371/journal.pntd.0006623
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http://dx.doi.org/10.1371/journal.pntd.0006623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319769PMC
December 2018
8 Reads

Cellular immunity in the insect Galleria mellonella against insect non-parasitic nematodes.

Parasitology 2018 Dec 20:1-8. Epub 2018 Dec 20.

Department of Applied Biological Sciences,Faculty of Agriculture,Saga University,Saga,Japan.

Immunity to microbial infections is well understood; however, information regarding the immunity to parasitic multicellular organisms remains lacking. To understand innate host cellular immunity to nematodes, we compared the cellular response of the greater wax moth (Galleria mellonella) larvae against the non-parasitic, bacterial-feeding nematode Caenorhabditis elegans and pathogenic nematode Heterorhabditis bacteriophora. When intact first-instar or dauer larvae of C. Read More

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http://dx.doi.org/10.1017/S003118201800210XDOI Listing
December 2018

Recent advances on Dirofilaria repens in dogs and humans in Europe.

Parasit Vectors 2018 Dec 19;11(1):663. Epub 2018 Dec 19.

National Centre of Vector Entomology, University of Zurich, Zurich, Switzerland.

Dirofilaria repens is a nematode affecting domestic and wild canids, transmitted by several species of mosquitoes. It usually causes a non-pathogenic subcutaneous infection in dogs and is the principal agent of human dirofilariosis in the Old World. In the last decades, D. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3205-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299983PMC
December 2018
8 Reads

[Investigation on intestinal nematode infections and their risk factors in Shanpo Sub-district, Jiangxia District, Wuhan City].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 May;30(5):567-570

Department of Human Parasitology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Objective: To investigate the infection status of intestinal nematodes and their risk factors in rural residents of Jiangxia District, Wuhan City, so as to provide the reference for the establishment of targeted prevention and control measures.

Methods: According to the requirements of cross-sectional study of the national human key parasitic diseases, the residents in Shanpo Sub-district, Jiangxia District were randomly selected as the objects for the investigation of the infection status of , hookworm and . A questionnaire survey was performed simultaneously. Read More

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http://dx.doi.org/10.16250/j.32.1374.2017159DOI Listing
May 2018
10 Reads

Detection of Mansonella ozzardi among blood donors from highly endemic interior cities of Amazonas state, northern Brazil.

Transfusion 2018 Dec 19. Epub 2018 Dec 19.

Departamento de Imunologia, Microbiologia, Patologia Geral e Parasitologia, Instituto de Patologia Tropical e Saúde Pública, IPTSP, Universidade Federal de Goiás UFG, Goiânia, Brasil.

Background: In the Brazilian Amazon, the filarial nematode Mansonella ozzardi co-exists with malaria parasites and thick blood smear microscopy is considered the diagnostic gold standard. Transfusion of M. ozzardi microfilariae does not establish new infections, however microfilariae can survive approximately 2 years in blood-recipients with unknown risk of pathology. Read More

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http://dx.doi.org/10.1111/trf.15101DOI Listing
December 2018
2 Reads