54,718 results match your criteria Nematode Infections


The lifestyle transition of Arthrobotrys oligospora is mediated by microRNA-like RNAs.

Sci China Life Sci 2019 Apr 23. Epub 2019 Apr 23.

State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming, 650091, China.

The lifestyle transition of fungi, defined as switching from taking organic material as nutrients to pathogens, is a fundamental phenomenon in nature. However, the mechanisms of such transition remain largely unknown. Here we show microRNA-like RNAs (milRNAs) play a key role in fungal lifestyle transition for the first time. Read More

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http://dx.doi.org/10.1007/s11427-018-9437-7DOI Listing

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing.

Int J Parasitol Drugs Drug Resist 2019 Apr 5;10:28-37. Epub 2019 Apr 5.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.

Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control nematode infections involves large scale treatment programs with anthelmintic drugs. This strategy is at risk from the emergence of drug resistant parasites. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113207183019
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http://dx.doi.org/10.1016/j.ijpddr.2019.04.001DOI Listing
April 2019
1 Read

Dracunculus infections in domestic dogs and cats in North America; an under-recognized parasite?

Vet Parasitol Reg Stud Reports 2018 Aug 5;13:148-155. Epub 2018 Jun 5.

Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, Wildlife Health Building, 589 D.W. Brooks Dr., Athens, GA 30602, USA; Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA 30602, USA. Electronic address:

We reviewed 62 new cases and 18 published reports of Dracunculus infections in domestic dogs and cats to describe the epidemiology of this parasite in dogs and cats in North America. We collected host and parasite data when available, including age, sex, and breed of dog, nematode location in the host, and any clinical signs at presentation and/or description of the apparent lesion. For dogs, infections were noted in six of the AKC breed groups, but none was reported from the toy group or the miscellaneous breed class. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183002
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http://dx.doi.org/10.1016/j.vprsr.2018.05.005DOI Listing
August 2018
1 Read

Molecular analysis of benzimidazole-resistance associated SNPs in Haemonchus contortus populations of Uruguay.

Vet Parasitol Reg Stud Reports 2018 Aug 17;13:110-114. Epub 2018 May 17.

Área de Farmacología, Depto. CIENFAR, Facultad de Química, Universidad de la República (Udelar), General Flores 2124, 11800 Montevideo, Uruguay.

Haemonchus contortus is one of the most important parasite nematodes of small ruminants around the world and causes great economic losses in livestock production. Control of gastrointestinal nematode infections, like haemonchosis, relies mainly on anthelmintic drugs, but its excessive and inappropriate use has caused serious drug resistance issues in many countries, including Uruguay, where sheep production occupies an important place in the country's economy. Benzimidazole (BZ) anthelmintics have been used for decades to treat sheep against H. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.05.001DOI Listing

Helminth infections in chickens (Gallus domesticus) raised in different production systems in Brazil.

Vet Parasitol Reg Stud Reports 2018 05 13;12:55-60. Epub 2018 Feb 13.

Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatuba, Rua Clóvis Pestana, 793, CEP 16050-680 Araçatuba, SP, Brazil. Electronic address:

The current study evaluated helminth infections in birds raised in different production systems for different purposes (extensive/dual-purpose, semi-intensive/broiler, semi-intensive/hen, intensive/hen and intensive/broiler) in Brazil. A total of 374 birds was assessed for helminths at necropsy using standard parasitological methods. During the necropsies, organs from the gastrointestinal tract (crop, esophagus, proventriculus, gizzard, small intestine, large intestine and ceca) of each bird were collected and the contents fixed in 70% ethanol. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.02.003DOI Listing

Molecular Characterization of a Cysteine Protease Inhibitor (Cystatin) and Its Possible Role in Filarial Immune Evasion.

Genes (Basel) 2019 Apr 12;10(4). Epub 2019 Apr 12.

Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

Infection with canine heartworm (), spread via mosquito vectors, causes coughing, asthma, pneumonia, and bronchitis in humans and other animals. The disease is especially severe and often fatal in dogs and represents a serious threat to public health worldwide. Cysteine protease inhibitors (CPIs), also known as cystatins, are major immunomodulators of the host immune response during nematode infections. Read More

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https://www.mdpi.com/2073-4425/10/4/300
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http://dx.doi.org/10.3390/genes10040300DOI Listing
April 2019
1 Read

Anti-infective potential of hydroalcoholic extract of   peel against gram-negative bacterial pathogens.

F1000Res 2019 18;8:70. Epub 2019 Jan 18.

Institute of Science, Nirma University, Ahmedabad, Gujarat, 382481, India.

extracts have been prescribed in traditional medicine for management of a variety of disease conditions including microbial infections. Generation of scientific evidence for validation of peel extract's anti-pathogenic efficacy is required. Hydroalcoholic extract of peel (PGPE), prepared by microwave assisted extraction method was evaluated for its quorum-modulatory potential against two different human-pathogenic bacteria viz. Read More

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http://dx.doi.org/10.12688/f1000research.17430.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392158.2PMC
January 2019
1 Read

Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans.

Parasit Vectors 2019 Apr 11;12(1):166. Epub 2019 Apr 11.

Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.

Background: Culicoides (Diptera; Ceratoponidae) are tiny, stout, blood-sucking flies with a near worldwide distribution. When present, they are often considered a biting nuisance but in addition, they are involved in the transmission of pathogens to humans, domestic and wild animals. Data on Culicoides species in the South-West region of Cameroon dates back to the 1950s. Read More

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http://dx.doi.org/10.1186/s13071-019-3432-9DOI Listing

A Novel Virulence Phenotype Rapidly Assesses Fungal Pathogenesis in Healthy and Immunocompromised Hosts.

mSphere 2019 04 10;4(2). Epub 2019 Apr 10.

Department of Biology, Emory University, Atlanta, Georgia, USA

The yeast is an opportunistic pathogen of humans, meaning that despite commensal interactions with its host, it can transition to a harmful pathogen. While is the predominant species isolated in the human gastrointestinal mycobiome and is implicated in fungal infection, infections due to non-albicans species are rapidly rising. Studying the factors that contribute to virulence is often challenging and frequently depends on many contexts, including host immune status and pathogen genetic background. Read More

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http://dx.doi.org/10.1128/mSphere.00697-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458437PMC

Risk factors for lymphatic filariasis in two villages of the Democratic Republic of the Congo.

Parasit Vectors 2019 Apr 11;12(1):162. Epub 2019 Apr 11.

IRD UMI 233, INSERM U1175, Université de Montpellier, Unité TransVIHMI, 911 Avenue Agropolis, P.O. Box 64501, 34394, Montpellier, France.

Background: Little is known regarding risk factors for lymphatic filariasis (LF) in Central Africa. To expand on what is known, we studied the epidemiology of LF in two endemic villages in the Democratic Republic of the Congo.

Methods: Dependent variables were Wuchereria bancrofti antigenaemia detected with filarial test strips (FTS) and microfilaraemia detected by night blood smears. Read More

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http://dx.doi.org/10.1186/s13071-019-3428-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458702PMC
April 2019
6 Reads

Suppression of obesity by an intestinal helminth through interactions with intestinal microbiota.

Infect Immun 2019 Apr 8. Epub 2019 Apr 8.

Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan

Obesity is increasingly causing lifestyle diseases in developed countries where helminthic infections are rarely seen. Here, we investigated whether an intestinal nematode, (Hp), has a suppressive role for diet-induced obesity in mice. Infection with Hp suppressed weight gain in obese mice, which was associated with increased uncoupling protein 1 (UCP1) expression in adipocytes and a higher serum norepinephrine (NE) concentration. Read More

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http://dx.doi.org/10.1128/IAI.00042-19DOI Listing
April 2019
2 Reads

Diagnosis of feline filariasis assisted by a novel semi-automated microfluidic device in combination with high resolution melting real-time PCR.

Parasit Vectors 2019 Apr 8;12(1):159. Epub 2019 Apr 8.

Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: The diagnosis of filariasis traditionally relies on the detection of circulating microfilariae (mf) using Giemsa-stained thick blood smears. This approach has several limitations. We developed a semi-automated microfluidic device to improve and simplify the detection of filarial nematodes. Read More

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http://dx.doi.org/10.1186/s13071-019-3421-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454708PMC

Improving the specific diagnosis of trematode, cestode and nematode infections by a multiplex single-tube real-time PCR assay.

J Clin Pathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Aims: Helminth infections are becoming uncommon in high-income countries and laboratory staff may lose expertise in their morphological identification, especially in histological sections where speciation of helminths is challenging. Commercially available molecular diagnostic panels for faecal specimens only offer tests for protozoa but not helminths. We aim to improve the identification accuracy of helminths using a multiplex PCR assay. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205590DOI Listing
April 2019
2 Reads

Gastrointestinal helminths of backyard chickens in selected areas of West Shoa Zone Central, Ethiopia.

Vet Parasitol Reg Stud Reports 2019 Jan 23;15:100265. Epub 2019 Jan 23.

Department of Veterinary Sciences, Ambo University, P. O. Box 19, Ambo, Ethiopia.

Gastrointestinal parasites of chickens are prevalent in many parts of the world including Ethiopia. This study was conducted with backyard chickens in Ambo, Holeta and, Dire Inchini in the West Shoa zone with the objectives of estimating the prevalence of gastrointestinal helminth infections, identifying the species present and determining associated risk factors. A cross-sectional study was conducted using 252 chickens purchased from local markets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24059390183007
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http://dx.doi.org/10.1016/j.vprsr.2019.100265DOI Listing
January 2019
2 Reads

Parasitic nematodes simultaneously suppress and benefit from coccidian coinfection in their natural mouse host.

Parasitology 2019 Mar 27:1-11. Epub 2019 Mar 27.

Institute of Evolutionary Biology and Centre for Immunity, Infection and Evolution,School of Biological Sciences, University of Edinburgh,Edinburgh UK, EH9 3FL,UK.

Within-host interactions among coinfecting parasites are common and have important consequences for host health and disease dynamics. However, these within-host interactions have traditionally been studied in laboratory mouse models, which often exclude important variation and use unnatural host-parasite combinations. Conversely, the few wild studies of within-host interactions often lack knowledge of parasite exposure and infection history. Read More

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http://dx.doi.org/10.1017/S0031182019000192DOI Listing
March 2019
4 Reads

A Novel Non-invasive Method to Detect RELM Beta Transcript in Gut Barrier Related Changes During a Gastrointestinal Nematode Infection.

Front Immunol 2019 12;10:445. Epub 2019 Mar 12.

Department of Veterinary Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany.

Currently, methods for monitoring changes of gut barrier integrity and the associated immune response via non-invasive means are limited. Therefore, we aimed to develop a novel non-invasive technique to investigate immunological host responses representing gut barrier changes in response to infection. We identified the mucous layer on feces from mice to be mainly composed of exfoliated intestinal epithelial cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423163PMC
March 2019
1 Read

First Record of A Species of Mermithidae Braun, 1883 Infecting a Decapod, Palaemon paludosus (Palaemonidae).

J Parasitol 2019 Apr;105(2):237-247

1   School of Fisheries, Aquaculture, & Aquatic Sciences, Auburn University, 203 Swingle Hall, Auburn, Alabama 36849.

The hemocoel of 26 of 30 (86%) eastern grass shrimps, Palaemon paludosus (Gibbes, 1850) (Decapoda: Palaemonidae), captured during June 2017 from several freshwater lakes near Leesburg and Lake Kissimmee, Florida, was infected by juveniles of a nematode species (Mermithidae sp.). Some infected eastern grass shrimps were preserved whole for histopathology, whereas others were dissected to excise parasitic juvenile nematodes, and still others were kept alive in glass aquaria such that post-parasitic (emerged) juvenile nematodes could be opportunistically observed alive and ultimately preserved. Read More

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April 2019
6 Reads

Divergent selection on milk somatic cell count in goats improves udder health and milk quality with no effect on nematode resistance.

J Dairy Sci 2019 Mar 20. Epub 2019 Mar 20.

Infectiologie et santé publique (ISP), INRA, Université Tours, Nouzilly, F-37380, France.

Milk somatic cell count (SCC) is commonly higher in goats than in cattle and sheep. Furthermore, the ability of milk SCC to predict mastitis is considered lower in goats than in cattle and sheep, and the relevance of somatic cell score (SCS)-based selection in this species has been questioned. To address this issue, we created 2 divergent lines of Alpine goats using artificially inseminated bucks with extreme estimated breeding values for SCS. Read More

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http://dx.doi.org/10.3168/jds.2018-15664DOI Listing
March 2019
3 Reads

Causes of Mortality and Lesions Observed Post mortem in European Moles (Talpa europaea) in Cornwall, South-west England.

J Comp Pathol 2019 Feb 27;167:18-25. Epub 2018 Dec 27.

Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, United Kingdom. Electronic address:

European moles (Talpa europaea) are a common species in the UK, but there are few published data on the causes of mortality in these animals. An opportunistic post-mortem study was carried out on 44 moles found dead or dying in Cornwall, UK. Assessment of muscle condition and fat reserves, where possible, indicated that most (27 of 37, 73%) were in good nutritive condition. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.11.006DOI Listing
February 2019
1 Read

Impact of 19 years of mass drug administration with ivermectin on epilepsy burden in a hyperendemic onchocerciasis area in Cameroon.

Parasit Vectors 2019 Mar 19;12(1):114. Epub 2019 Mar 19.

Global Health Institute, University of Antwerp, Antwerp, Belgium.

Background: Surveys conducted in 1991-1992 in the Mbam Valley (Cameroon) revealed that onchocerciasis was highly endemic, with community microfilarial loads (CMFL) > 100 microfilariae/snip in some villages. Also in 1991-1992, a survey of suspected cases of epilepsy (SCE) found 746 SCE using a questionnaire administered to individuals identified by key informants, with prevalences reaching 13.6% in some communities. Read More

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http://dx.doi.org/10.1186/s13071-019-3345-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423875PMC
March 2019
1 Read

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus.

BMC Genomics 2019 Mar 15;20(1):218. Epub 2019 Mar 15.

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infect livestock and companion animals, and there are growing concerns regarding the reduced efficacy in some human-infective helminths. Understanding the mechanisms by which resistance evolves is the focus of increasing interest; robust genetic analysis of helminths is challenging, and although many candidate genes have been proposed, the genetic basis of resistance remains poorly resolved. Read More

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http://dx.doi.org/10.1186/s12864-019-5592-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420744PMC
March 2019
3.986 Impact Factor

Hepatocellular carcinoma-associated antigen 59 of Haemonchus contortus modulates the functions of PBMCs and the differentiation and maturation of monocyte-derived dendritic cells of goats in vitro.

Parasit Vectors 2019 Mar 14;12(1):105. Epub 2019 Mar 14.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, PR China.

Background: Hepatocellular carcinoma-associated antigen 59 (HCA59), which is one of the most important excretory/secretory products of Haemonchus contortus (HcESPs), is known to have antigenic functions. However, its immunomodulatory effects on host cells are poorly understood.

Methods: Here, we cloned the HCA59 gene and expressed the recombinant protein of HCA59 (rHCA59). Read More

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http://dx.doi.org/10.1186/s13071-019-3375-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416944PMC
March 2019
1 Read

Pilot study evaluating the efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural feline troglostrongylosis.

Parasit Vectors 2019 Mar 12;12(1):97. Epub 2019 Mar 12.

Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy.

Background: Troglostrongylus brevior, a lungworm usually affecting wild felids, has been recently recorded in a number of cases in domestic cats, mainly in Mediterranean areas. Although feline troglostrongylosis is a severe and life-threatening disease, especially in young cats, treatment options are very limited. The present study evaluated the efficacy and safety of a spot-on formulation containing emodepside 2. Read More

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http://dx.doi.org/10.1186/s13071-019-3361-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417080PMC

A detection of benzimidazole resistance-associated SNPs in the isotype-1 β-tubulin gene in Haemonchus contortus from wild blue sheep (Pseudois nayaur) sympatric with sheep in Helan Mountains, China.

BMC Vet Res 2019 Mar 12;15(1):89. Epub 2019 Mar 12.

College of Wildlife Resources, Northeast Forestry University, Harbin, China.

Background: Benzimidazole (BZ) resistance is an increasingly serious problem due to the excessive use of this anthelmintic for controlling Haemonchus contortus, which is one of the major gastrointestinal nematodes infecting small ruminants worldwide. Three known single nucleotide polymorphisms (SNPs), F167Y (TAC), E198A (GCA) and F200Y (TAC), in the isotype-1 β-tubulin gene of H. contortus are associated with BZ resistance. Read More

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http://dx.doi.org/10.1186/s12917-019-1838-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416841PMC
March 2019
1 Read

Mapping of lymphatic filariasis in loiasis areas: A new strategy shows no evidence for Wuchereria bancrofti endemicity in Cameroon.

PLoS Negl Trop Dis 2019 03 8;13(3):e0007192. Epub 2019 Mar 8.

Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Background: Mapping of lymphatic filariasis (LF) caused by Wuchereria bancrofti largely relies on the detection of circulating antigen using ICT cards. Several studies have recently shown that this test can be cross-reactive with sera of subjects heavily infected with Loa loa and thus mapping results in loiasis endemic areas may be inaccurate.

Methodology/principal Findings: In order to develop an LF mapping strategy for areas with high loiasis prevalence, we collected day blood samples from 5,001 subjects residing in 50 villages that make up 6 health districts throughout Cameroon. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436748PMC
March 2019
132 Reads

Sheep enteric cestodes and their influence on clinical indicators used in targeted selective treatments against gastrointestinal nematodes.

Onderstepoort J Vet Res 2019 Feb 28;86(1):e1-e3. Epub 2019 Feb 28.

Institute of Veterinary Sciences and Agronomic Sciences, University of Batna 1.

Clinical indicators such as diarrhoea (DISCO) or anaemia (FAMACHA©) are used as a measure for targeted selective treatments against gastrointestinal nematodes (GIN). Enteric cestodes such as Moniezia may interfere directly with DISCO or indirectly with the FAMACHA© score. We investigated 821 Ouled Djellal rams naturally infected in a steppe environment (GIN alone, cestodes alone, GIN and cestodes) or not. Read More

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http://dx.doi.org/10.4102/ojvr.v86i1.1648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407454PMC
February 2019
4 Reads

Establishment of a Tm-shift Method for Detection of Cat-Derived Hookworms.

Korean J Parasitol 2019 Feb 26;57(1):9-15. Epub 2019 Feb 26.

Guangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510542, P. R. China.

Melting temperature shift (Tm-shift) is a new detection method that analyze the melting curve on real-time PCR thermocycler using SYBR Green I fluorescent dye. To establish a Tm-shift method for the detection of Ancylostoma ceylanicum and A. tubaeforme in cats, specific primers, with GC tail of unequal length attached to their 5 ́ end, were designed based on 2 SNP loci (ITS101 and ITS296) of the internal transcribed spacer 1 (ITS1) sequences. Read More

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http://dx.doi.org/10.3347/kjp.2019.57.1.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409220PMC
February 2019
2 Reads

Antipathogenic Potential of a Polyherbal Wound-Care Formulation (Herboheal) against Certain Wound-Infective Gram-Negative Bacteria.

Adv Pharmacol Sci 2019 27;2019:1739868. Epub 2019 Jan 27.

Institute of Science, Nirma University, Ahmedabad-382481, India.

This study investigated antipathogenic efficacy of a polyherbal wound-healing formulation Herboheal against three multidrug-resistant strains of gram-negative bacterial pathogens associated with wound infections. Herboheal was evaluated for its quorum-modulatory potential against three different human-pathogenic bacteria, first through the broth dilution assay and then in the model host . Herboheal at ≥0. Read More

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http://dx.doi.org/10.1155/2019/1739868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369513PMC
January 2019

The Global Burden of Disease of Zoonotic Parasitic Diseases: Top 5 Contenders for Priority Consideration.

Authors:
Konrad Pisarski

Trop Med Infect Dis 2019 Mar 2;4(1). Epub 2019 Mar 2.

Division of Tropical Health & Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4814, Australia.

With the rise of global migration, international trade, and global environmental challenges such as climate change, it is not surprising that the interactions between humans and other animals are shifting. Salient infectious diseases, such as malaria and HIV (which have high burdens of disease), attract sophisticated public health frameworks and funding from global/regional organisations, such as the WHO. This unfortunately detracts attention from the many emerging zoonoses that fall under the radar as neglected tropical diseases (NTDs). Read More

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http://dx.doi.org/10.3390/tropicalmed4010044DOI Listing

Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum.

Exp Parasitol 2019 Apr 1;199:52-58. Epub 2019 Mar 1.

Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), UNCPBA-CICPBA-CONICET, Facultad de Ciencias Veterinarias, Campus Universitario, 7000, Tandil, Argentina.

Ascaris suum is a widespread parasitic nematode that causes infection in pigs with high prevalence rates. Oxfendazole (OFZ) is effective against A. suum when used at a single high oral dose of 30 mg/kg. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.02.017DOI Listing
April 2019
3 Reads

Survey of husbandry practices for bovidae in zoos: the importance of parasite management for reintroduction programmes.

Vet Rec 2019 Mar;184(9):282

Departamento de Ecología Funcional y Evolutiva, Estación Experimental de Zonas Áridas, Consejo Superior de Investigaciones Científicas, Almeria, Spain.

Animals from zoological institutions may be used for reintroductions. These individuals are considered healthy, but they are not necessarily free of parasites, despite the minimum husbandry standards required of zoological institutions as described in the European Association of Zoos and Aquaria guidelines. In this sense, parasitism has been identified as the cause of failure, or has added difficulties, in some reintroduction programmes. Read More

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http://dx.doi.org/10.1136/vr.104985DOI Listing
March 2019
1 Read

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

PLoS Negl Trop Dis 2019 02 28;13(2):e0007159. Epub 2019 Feb 28.

Global Pharmaceutical Research and Development, AbbVie, North Chicago, Illinois, United States of America.

There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administration (MDA) with current microfilaricides, and to provide a solution to treatment of onchocerciasis / loiasis co-infection, where MDA is restricted. We have identified a novel macrofilaricidal agent, Tylosin A (TylA), which acts by targeting the worm-symbiont Wolbachia bacterium. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413952PMC
February 2019
5 Reads

The draft genome of strain Cpun from biting midges confirms insect are not a monophyletic group and reveals a novel gene family expansion in a symbiont.

PeerJ 2019 21;7:e6448. Epub 2019 Feb 21.

Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.

Background: It is estimated that 13% of arthropod species carry the heritable symbiont . 16S rRNA and gyrB sequence divides this species into at least four groups (A-D), with the A group infecting a range of arthropods, the B group infecting nematode worms, the C group infecting biting midges, and the D group associated with the marine copepod . To date, genome sequence has only been available for strains from groups A and B, impeding general understanding of the evolutionary history of the radiation. Read More

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https://peerj.com/articles/6448
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http://dx.doi.org/10.7717/peerj.6448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387759PMC
February 2019
3 Reads

Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar.

PLoS Negl Trop Dis 2019 02 15;13(2):e0006591. Epub 2019 Feb 15.

Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.

Background: Mass drug administration (MDA), targeted at school-aged children (SAC) is the method recommended by the World Health Organization for the control of morbidity induced by soil-transmitted helminth (STH) infection in endemic countries. However, MDA does not prevent reinfection between treatment rounds and research suggests that only treating SAC will not be sufficient to bring prevalence to low levels and possibly interrupt transmission of STH. In countries with endemic infection, such as Myanmar, the coverage, who is targeted, and rates of reinfection will determine how effective MDA is in suppressing transmission in the long-term. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395004PMC
February 2019

Ovicidal and larvicidal effects of extracts from leaves of Andrographis paniculata (Burm. f.) Wall.ex Nees against field isolates of human hookworm (Ancylostoma duodenale).

J Ethnopharmacol 2019 May 11;235:489-500. Epub 2019 Feb 11.

Department of Biological Science, Adamawa State University, P.M.B. 25, Mubi, Nigeria. Electronic address:

Ethnopharmacological Relevance: The whole plant of Andrographis paniculata (Burm. f.) Wall. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.021DOI Listing
May 2019
16 Reads
2.998 Impact Factor

[Trichinellosis outbreaks in Aragón (1998-2017)].

Rev Esp Salud Publica 2019 Feb 15;93. Epub 2019 Feb 15.

Sección de Vigilancia Epidemiológica. Servicio Provincial de Sanidad de Zaragoza. Gobierno de Aragón. Zaragoza. España.

Objective: In Aragon, official veterinary controls to detect the presence of Trichinella in meat products have allowed trichinosis to be a low-incidence disease in the form of outbreaks associated with family consumption of meat products that are not sanitarily controlled. The aim of the work was to describe the epidemiological characteristics of the trichinosis outbreaks that occurred in Aragon during the study period and the action measures carried out, which served as a basis for redesigning and strengthening prevention and control measures.

Methods: Descriptive study of the characteristics of time, place, person, food implicated, etiological agent and control measures implemented in the outbreaks identified by the Epidemiological Surveillance Network of Aragón from 01/01/1998 to 31/12/2017. Read More

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February 2019
3 Reads

The investigation of Strongyloides stercoralis seroprevalence in immunosupressed patients in Turkey

Turk J Med Sci 2019 Feb 11;49(1):16-19. Epub 2019 Feb 11.

Background/aim: In immunosuppressed patients, strongyloidiasis can be lifethreatening because of hyperinfection or dissemination. Therefore, diagnosis of S. stercoralis is important in immunosuppressed patients with chronic strongyloidiasis. Read More

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http://dx.doi.org/10.3906/sag-1804-16DOI Listing
February 2019
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Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis.

Trop Med Infect Dis 2019 Feb 12;4(1). Epub 2019 Feb 12.

Department of Medicine, Division of Infectious Diseases, University of Texas Health, San Antonio, TX 78229, USA.

Strongyloidiasis, due to infection with the nematode , affects millions of people in the tropics and subtropics. has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Read More

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http://dx.doi.org/10.3390/tropicalmed4010035DOI Listing
February 2019
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The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes.

PLoS Pathog 2019 02 13;15(2):e1007598. Epub 2019 Feb 13.

INTHERES, Université de Toulouse, INRA, ENVT, Toulouse, France.

Resistance to the anthelmintic macrocyclic lactone ivermectin (IVM) has a great impact on the control of parasitic nematodes. The mechanisms by which nematodes adapt to IVM remain to be deciphered. We have identified NHR-8, a nuclear hormone receptor involved in the xenobiotic response in Caenorhabditis elegans, as a new regulator of tolerance to IVM. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007598
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http://dx.doi.org/10.1371/journal.ppat.1007598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391013PMC
February 2019
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Intestinal nematode infection exacerbates experimental visceral leishmaniasis.

Parasite Immunol 2019 Apr 4;41(4):e12618. Epub 2019 Mar 4.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna, Sweden.

Leishmania donovani exposure often results in subclinical infection in immunocompetent individuals, and the factors dictating development of visceral leishmaniasis (VL) are not known. Infection with intestinal worms skew immunity towards type 2 and regulatory responses, thereby theoretically increases susceptibility to intracellular infections controlled by type 1 responses. Here we have tested how chronic infection with the intestinal nematode Heligmosomoides polygyrus affected immunity to a secondary infection with L donovani. Read More

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http://dx.doi.org/10.1111/pim.12618DOI Listing

Ascaris suum infection was associated with a worm-independent reduction in microbial diversity and altered metabolic potential in the porcine gut microbiome.

Int J Parasitol 2019 Mar 8;49(3-4):247-256. Epub 2019 Feb 8.

United States Department of Agriculture, Agricultural Research Service, Animal Parasitic Disease Laboratory, Beltsville, MD, USA. Electronic address:

The effect of infection of pigs with Ascaris suum on the microbial composition in the proximal colon and fecal matter was investigated using 16S rRNA gene sequencing. The infection significantly decreased various microbial diversity indices including Chao1 richness, but the effect on Chao1 in the colon luminal contents was worm burden-independent. The abundance of 49 genera present in colon contents, such as Prevotella and Faecalibacterium, and 179 operational taxonomic units was significantly changed as a result of infection. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.10.007DOI Listing
March 2019
1 Read
3.872 Impact Factor

Comprehensive management of epilepsy in onchocerciasis-endemic areas: lessons learnt from community-based surveys.

Infect Dis Poverty 2019 Feb 10;8(1):11. Epub 2019 Feb 10.

Global Health Institute, University of Antwerp, Antwerp, Belgium.

Background: Onchocerciasis-endemic regions are known to have a high epilepsy prevalence. Limited resources in these areas and poor access to healthcare by persons with epilepsy (PWE) result in a wide anti-epileptic treatment gap, poor seizure control and a high burden of seizure-related complications. Recent community-based surveys highlight the need for epilepsy management strategies suitable for remote onchocerciasis-endemic villages to ensure better health outcomes for PWE. Read More

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https://idpjournal.biomedcentral.com/articles/10.1186/s40249
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http://dx.doi.org/10.1186/s40249-019-0523-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368958PMC
February 2019
3 Reads

Lethal strongyloidiasis - Diagnostic and forensic issues.

Authors:
Roger W Byard

J Forensic Leg Med 2019 Feb 2;62:103-106. Epub 2019 Feb 2.

School of Medicine, Level 2 Medical School North Building, The University of Adelaide, Frome Road, Forensic Science South Australia (FSSA), Adelaide, 5005, SA, Australia. Electronic address:

Strongyloidiasis is an infectious disease affecting approximately 30-100 million people globally. The main human pathogen is Strongyloides stercoralis which may cause a brief period of acute symptoms and signs after the initial infection, and then lapse into a chronic asymptomatic carrier state for decades due to the nematode's unique ability to autoinfect hosts. Immunosuppression from steroid therapy, T-lymphocytic viral (HTLV-1) infections, or a variety of underlying medical conditions may then result in dissemination and the highly lethal and infectious hyperinfection syndrome. Read More

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http://dx.doi.org/10.1016/j.jflm.2019.01.014DOI Listing
February 2019
3 Reads

Epidemiology of gastrointestinal nematodes of alpacas in Australia: II. A longitudinal study.

Parasitol Res 2019 Mar 9;118(3):901-911. Epub 2019 Feb 9.

Department of Veterinary Biosciences, Melbourne Veterinary School, The University of Melbourne, Werribee, Victoria 3030, Australia.

We conducted a longitudinal survey on 13 alpaca farms in four climatic zones of Australia to understand the epidemiology of gastrointestinal nematodes (GINs) of alpacas. A total of 1688 fresh faecal samples were collected from both sexes of alpacas from May 2015 to April 2016 and processed for faecal egg counts (FEC) and molecular identification of eggs using the multiplexed-tandem PCR assay. Based on egg morphology, the overall prevalence of GINs was 61% while that for strongyles was 53%. Read More

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http://dx.doi.org/10.1007/s00436-019-06236-7DOI Listing
March 2019
2 Reads

Molecular data reveal cryptic speciation and host specificity in Toxascaris leonina (Nematoda: Ascarididae).

Vet Parasitol 2019 Feb 17;266:80-83. Epub 2019 Jan 17.

Department of Biology and Environmental Protection, Poznań University of Physical Education, Królowej Jadwigi 27/39, 61-871, Poznań, Poland.

Toxascaris leonina (Ascarididae) is a cosmopolitan and polyxenical parasite whose host are canids and felids. To date, molecular phylogenetic studies included toxascarid representatives collected only from dogs or felids, therefore the intra-species differences between T. leonina collected from different host species has not been noticed. Read More

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http://dx.doi.org/10.1016/j.vetpar.2019.01.002DOI Listing
February 2019
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Anthelmintic activity of injectable eprinomectin (eprecis 20 mg/mL) in naturally infected dairy sheep.

Vet Parasitol 2019 Feb 6;266:7-11. Epub 2019 Jan 6.

Laboratory of Animal Husbandry, Faculty of Veterinary Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124, Greece. Electronic address:

The anthelmintic activity of an injectable eprinomectin formulation (Eprecis 20 mg/mL) was evaluated in 150 naturally infected dairy sheep raised in 3 semi-intensive flocks. All ewes were at the same stage of lactation and grazed on natural pastures. Ewes did not receive any anthelmintic treatment for at least 4 months prior to the experiment. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.014DOI Listing
February 2019
3 Reads

Is the Famacha system always the best criterion for targeted selective treatment for the control of haemonchosis in growing lambs?

Vet Parasitol 2019 Feb 6;266:67-72. Epub 2019 Jan 6.

Graduate Program in Animal Science, School of Life Sciences, Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Paraná, 80215-901, Brazil. Electronic address:

Targeted selective treatment (TST) aims to aid in the control of gastrointestinal nematodes in small ruminants, identifying animals that require treatment with the purpose of preserving the Refugia population and delaying the buildup of anthelmintic (AH) resistance. The objective of this study was to evaluate the effectiveness of both productive and clinical indicators in the selective treatment of gastrointestinal parasites in growing lambs. Two experiments were carried out between 2015 and 2016. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.015DOI Listing
February 2019
2 Reads

Seroprevalence, biogeographic distribution and risk factors for Aelurostrongylus abstrusus infections in Swiss cats.

Vet Parasitol 2019 Feb 4;266:27-33. Epub 2019 Jan 4.

Institute of Parasitology, University of Zurich, Vetsuisse Faculty, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

The metastrongyloid nematode Aelurostrongylus abstrusus is a worldwide occurring feline lungworm. The spectrum of clinical signs in infected cats ranges from mild (e.g. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.013DOI Listing
February 2019
2 Reads

Anthelmintic effect and tissue alterations induced in vitro by hydrolysable tannins on the adult stage of the gastrointestinal nematode Haemonchus contortus.

Vet Parasitol 2019 Feb 24;266:1-6. Epub 2018 Dec 24.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Sinaloa. Boulevard San Ángel S/N, Fraccionamiento San Benito, 80246. Culiacán, Sinaloa, Mexico. Electronic address:

Haemonchus contortus constitutes a severe problem for ruminant's production, it is the most frequent nematode parasite both in template and tropical regions, induces economical losses, and shows increasing resistance to currently available anthelmintics. Tannins are secondary metabolites that naturally fulfill defense functions in plants, representing a non-conventional, natural alternative in the treatment of gastrointestinal parasites in sheep. The objective of this work was to explore the in vitro anthelmintic activity of hydrolysable tannins on adult stage of Haemonchus contortus. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.008DOI Listing
February 2019
3 Reads

Worm burdens and associated histopathological changes caused by gastrointestinal nematodes in alpacas from Australia.

Parasitol Res 2019 Mar 8;118(3):1031-1038. Epub 2019 Feb 8.

Department of Veterinary Biosciences, Melbourne School of Veterinary Science, The University of Melbourne, Werribee, Victoria 3030, Australia.

In this study, 100 gastrointestinal tracts of Australian alpacas were examined to assess the worm burden and to identify the species of nematode present. Faecal samples were collected from 97 alpacas and processed for faecal egg counts (FECs). For identification of the species, both molecular (multiplexed-tandem polymerase chain reaction [MT-PCR]) and morphological techniques were used. Read More

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http://dx.doi.org/10.1007/s00436-019-06237-6DOI Listing
March 2019
4 Reads