83,862 results match your criteria Nematode Infections


Polyphenol enriched ethanolic extract of Cajanus scarabaeoides (L.) Thouars exerts potential antifilarial activity by inducing oxidative stress and programmed cell death.

PLoS One 2018 6;13(12):e0208201. Epub 2018 Dec 6.

Parasitology Laboratory, Department of Zoology, Visva-Bharati University, Santiniketan, India.

Development of antifilarial drug from the natural sources is considered as one of the most efficacious, safe, and affordable approaches. In this study, we report the antifilarial activity of a leguminous plant Cajanus scarabaeoides (L.) Thouars. Read More

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December 2018
2 Reads

Trade-off between reproductive and anti-competitor abilities in an insect-parasitic nematode-bacteria symbiosis.

Ecol Evol 2018 Nov 18;8(22):10847-10856. Epub 2018 Oct 18.

Department of Biology Indiana University Bloomington Indiana.

Mutualistic symbionts can provide diverse benefits to their hosts and often supply key trait variation for host adaptation. The bacterial symbionts of entomopathogenic nematodes play a crucial role in successful colonization of and reproduction in the insect host. Additionally, these symbionts can produce a diverse array of antimicrobial compounds to deter within-host competitors. Read More

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November 2018

Populations of the Beet Cyst Nematode Exhibit Strong Differences in Their Life-History Traits Across Changing Thermal Conditions.

Front Microbiol 2018 16;9:2801. Epub 2018 Nov 16.

IGEPP, INRA, Agrocampus Ouest, Université de Rennes 1, Le Rheu, France.

It is widely accepted that climate has an essential influence on the distribution of species and that temperature is the major abiotic factor that affects their life-history traits. Species with very restricted active dispersal abilities and a wide geographical distribution are thus expected to encompass distinct populations adapted to contrasted local conditions. The beet cyst nematode is a good biological model to study temperature adaptation in populations collected from different environments. Read More

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November 2018

Oral vaccination with Trichinella spiralis DNase II DNA vaccine delivered by attenuated Salmonella induces a protective immunity in BALB/c mice.

Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More

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December 2018

Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.

Hum Mol Genet 2018 Dec;27(24):4176-4193

Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, USA.

Commonalities and, in some cases, pathological overlap between neurodegenerative diseases have led to speculation that targeting of underlying mechanisms might be of potentially shared therapeutic benefit. Alzheimer's disease is characterized by the formation of plaques, composed primarily of the amyloid-β 1-42 (Aβ) peptide in the brain, resulting in neurodegeneration. Previously, we have shown that overexpression of the lysosomal-trafficking protein, human Vps41 (hVps41), is neuroprotective in a transgenic worm model of Parkinson's disease, wherein progressive dopaminergic neurodegeneration is induced by α-synuclein overexpression. Read More

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December 2018

L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in .

Nutr Metab (Lond) 2018 26;15:83. Epub 2018 Nov 26.

1UNIPAMPA-Programa de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, BR 472 - Km 592, Caixa Postal 118, Uruguaiana, RS CEP 97500-970 Brazil.

Background: seeds have been commonly used by people that seek healthy habits through natural foods to reduce cholesterol and triacylglycerides levels, however, the evidences that support this assumption are still scarce in literature. Here, we aimed to evaluate the lipid lowering effects of chia by using as animal model, a nematode that has proven its usefulness for lipid metabolism studies.

Methods: We prepared hexane (HE) and Bligh-Dyer (BDE) extracts, evaluated and compared their safety, antioxidant potential and their lipid-lowering activity in the worms. Read More

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November 2018

The Genetic Architecture of Intra-Species Hybrid Mito-Nuclear Epistasis.

Front Genet 2018 16;9:481. Epub 2018 Nov 16.

Department of Biology, California State University, Fresno, Fresno, CA, United States.

Genetic variants that are neutral within, but deleterious between, populations (Dobzhansky-Muller Incompatibilities) are thought to initiate hybrid dysfunction and then to accumulate and complete the speciation process. To identify the types of genetic differences that might initiate speciation, it is useful to study inter-population (intra-species) hybrids that exhibit reduced fitness. In , a close relative of the nematode , such minor genetic incompatibilities have been identified. Read More

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November 2018

Free-Living Nematodes Together With Associated Microbes Play an Essential Role in Apple Replant Disease.

Front Plant Sci 2018 16;9:1666. Epub 2018 Nov 16.

Department of Epidemiology and Pathogen Diagnostics, Julius Kühn-Institut - Federal Research Centre for Cultivated Plants, Braunschweig, Germany.

Apple replant disease (ARD) is a severe problem in apple production worldwide. It is caused by a complex of soil biota, leading to small discolorated roots, as well as increased biosynthesis of phytoalexins, total phenolic compounds and antioxidants. We sampled soil from randomized field plots with either apple trees affected by ARD, which were five times replanted every second year, or with healthy trees growing in plots, which had a grass cover during this period. Read More

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November 2018

Worming into the Plant Chromatin: A Nematode Effector Influences Host Histone Acetylation.

Plant Cell 2018 Nov 30. Epub 2018 Nov 30.

Michigan State University CITY: East Lansing STATE: MI POSTAL_CODE: 48824 United States Of America [US]

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November 2018

Strategies for Efficient Genome Editing Using CRISPR-Cas9.

Genetics 2018 Nov 30. Epub 2018 Nov 30.

University of California, Berkeley

The targetable DNA endonuclease CRISPR-Cas9 has transformed analysis of biological processes by enabling robust genome editing in model and non-model organisms. Although rules directing Cas9 to its target DNA via a guide RNA are straightforward, wide variation occurs in editing efficiency and repair outcomes for both imprecise error-prone repair and precise templated repair. We found that imprecise and precise DNA repair from double-stranded breaks (DSBs) is asymmetric, favoring repair in one direction. Read More

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November 2018
2 Reads

Regulation of Root-Knot Nematode Behavior by Seed Coat Mucilage-Derived Attractants.

Mol Plant 2018 Nov 29. Epub 2018 Nov 29.

Graduate School of Science & Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, Kumamoto, 860-8555, Japan. Electronic address:

Seed exudates influence the behaviour of soil organisms, but how this occurs remains unclear, particularly for multicellular animals. Here we show that compounds associated with Arabidopsis seed coat mucilage regulate the behaviour of soil-borne animals, specifically root-knot nematodes (RKN). Infective RKN J2 larvae actively travel toward Arabidopsis seeds through chemotaxis. Read More

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November 2018
1 Read

Helminth Microbiomes - A Hidden Treasure Trove?

Trends Parasitol 2018 Nov 28. Epub 2018 Nov 28.

Department of Veterinary Medicine, University of Cambridge, Cambridge, CB3 0ES, UK. Electronic address:

There is increasing attention on the complex interactions occurring between gastrointestinal parasitic helminths and the microbial flora (microbiota) inhabiting the host gut. However, little is known about the occurrence, structure, and function of microbial populations residing within parasite organs and tissues. In this article, we argue that an in-depth understanding of the interplay between parasites and their microbiomes may significantly enhance current knowledge of parasite biology and physiology, and may lead to the discovery of entirely novel, anthelmintic-independent interventions against parasites and parasitic diseases. Read More

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November 2018

Anthelmintic drug actions in resistant and susceptible C. elegans revealed by electrophysiological recordings in a multichannel microfluidic device.

Int J Parasitol Drugs Drug Resist 2018 Dec 30;8(3):607-628. Epub 2018 Oct 30.

Institute of Neuroscience, University of Oregon, 1254 University of Oregon, Eugene, OR, 97403-1254, USA. Electronic address:

Many anthelmintic drugs used to treat parasitic nematode infections target proteins that regulate electrical activity of neurons and muscles: ion channels (ICs) and neurotransmitter receptors (NTRs). Perturbation of IC/NTR function disrupts worm behavior and can lead to paralysis, starvation, immune attack and expulsion. Limitations of current anthelmintics include a limited spectrum of activity across species and the threat of drug resistance, highlighting the need for new drugs for human and veterinary medicine. Read More

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December 2018

Eprinomectin pour-on: Prevention of gastrointestinal and pulmonary nematode infections in sheep.

Vet Parasitol 2018 Dec 8;264:42-46. Epub 2018 Nov 8.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101 Rohrdorf, Germany.

The present study was conducted to further characterize the anthelmintic activity of the 0.5% w/v topical formulation of eprinomectin (EPRINEX Pour-on, Merial) when administered at 1 mg/kg body weight to sheep in preventing the establishment of induced gastrointestinal and pulmonary nematode infections. Thirty-six female Merino sheep (∼4 months of age, weighing 27. Read More

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December 2018

Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection.

Vet Parasitol 2018 Dec 22;264:18-25. Epub 2018 Oct 22.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom; Department of Animal, Plant and Soil Sciences, AgriBio, 5 Ring Road, Bundoora, Victoria 3086, Melbourne, Australia.

Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Read More

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December 2018

Assessment of P-glycoprotein gene expression in adult stage of Haemonchus contortus in vivo exposed to ivermectin.

Vet Parasitol 2018 Dec 15;264:1-7. Epub 2018 Oct 15.

Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), CONICET-CICPBA-UNCPBA, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro (FCV-UNCPBA), Tandil, Argentina. Electronic address:

The efflux transporter P-glycoprotein (P-gp) has been implicated in multidrug resistance of different nematode parasites affecting livestock species. Increased expression of P-gp in nematodes after their in vitro as well as in vivo exposure to anthelmintics suggests a role of P-gp in drug resistance. The current study evaluated the P-gp gene expression in a highly-resistant isolate of the sheep nematode Haemonchus contortus, selected after exposure to ivermectin (IVM) treatments at 10-fold the therapeutic dose. Read More

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December 2018
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A survey of freshwater and terrestrial snails in a predominantly urban municipality of Rio de Janeiro State, Brazil, with emphasis on human parasites vectors.

Rev Inst Med Trop Sao Paulo 2018 Nov 29;60:e76. Epub 2018 Nov 29.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios, Rio de Janeiro, Rio de Janeiro, Brazil.

Many snail species act as intermediate hosts of helminths that transmit diseases to humans and animals, such as schistosomiasis and angiostrongyliasis. São Gonçalo, a mostly urban municipality in Rio de Janeiro State, Brazil, has undergone fundamental environmental impacts, which favor the establishment of a range of diseases, for which snails act as the intermediate hosts of the etiological agents. In the present study, freshwater and terrestrial snail populations were surveyed in different environments within five city districts, and the presence of helminths was determined in the collected specimens. Read More

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November 2018

Sublethal Effects of Ionic and Nanogold on the Nematode .

J Toxicol 2018 1;2018:6218193. Epub 2018 Nov 1.

Water Research Group, Unit for Environmental Sciences and Management, Potchefstroom Campus, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

The nematode is used as an ecotoxicological model species in both aqueous medium and solid substrates. It is easy and of low cost to maintain in the laboratory and it produces hundreds of offspring within a short period of time. It also has a small body size (1 mm), making it possible for assays to be conducted in 12-well plates. Read More

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November 2018

Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite Ostertagia ostertagi.

Sci Rep 2018 Dec 4;8(1):17598. Epub 2018 Dec 4.

Department of Avian and Animal Sciences, University of Maryland, College Park, MD, 20742, USA.

Ostertagia ostertagi (OO) is a widespread parasite that causes chronic infection in cattle and leads to annual losses of billions of dollars in the cattle industry. It remains unclear why cattle are unable to mount an effective immune response despite a large influx of immune cells to the infected abomasal mucosa and draining lymph nodes. Neutrophils, the immune system's first responders, have the capacity to release neutrophil extracellular traps (NETs) to contain various pathogens, including some parasites. Read More

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December 2018
1 Read

First report of in coyotes in mainland North America.

Vet Rec 2018 Dec 4. Epub 2018 Dec 4.

Department of Biology, Acadia University, Wolfville, Nova Scotia, Canada.

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December 2018

Adult Influence on Juvenile Phenotypes by Stage-Specific Pheromone Production.

iScience 2018 Nov 20;10:123-134. Epub 2018 Nov 20.

Department of Evolutionary Biology, Max Planck Institute for Developmental Biology, Tübingen 72076, Germany. Electronic address:

Many animal and plant species respond to population density by phenotypic plasticity. To investigate if specific age classes and/or cross-generational signaling affect density-dependent plasticity, we developed a dye-based method to differentiate co-existing nematode populations. We applied this method to Pristionchus pacificus, which develops a predatory mouth form to exploit alternative resources and kill competitors in response to high population densities. Read More

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November 2018
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Morphological and molecular characterization of Megalobatrachonema hainanensis sp. nov. (Nematoda: Ascaridida), with phylogenetic position of Megalobatrachonema in Cosmocercoidea.

J Helminthol 2018 Dec 4:1-7. Epub 2018 Dec 4.

Key Laboratory of Animal Physiology,Biochemistry and Molecular Biology of Hebei Province,College of Life Sciences, Hebei Normal University,050024 Shijiazhuang,Hebei Province,People's Republic of China.

The genus Megalobatrachonema is a rare group of nematode parasites within Ascaridida. The systematic status of Megalobatrachonema in the superfamily Cosmocercoidea (Ascaridida) has long been controversial. The relationship of Megalobatrachonema and Chabaudgolvania remains unsolved. Read More

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December 2018

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

PLoS Pathog 2018 Nov 30;14(11):e1007423. Epub 2018 Nov 30.

Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

Ym1 and RELMα are established effector molecules closely synonymous with Th2-type inflammation and associated pathology. Here, we show that whilst largely dependent on IL-4Rα signaling during a type 2 response, Ym1 and RELMα also have IL-4Rα-independent expression patterns in the lung. Notably, we found that Ym1 has opposing effects on type 2 immunity during nematode infection depending on whether it is expressed at the time of innate or adaptive responses. Read More

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November 2018
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A new Trichuris species (Nematoda: Trichuridae) from capybaras: Morphological-molecular characterization and phylogenetic relationships.

Acta Trop 2018 Nov 27;190:244-252. Epub 2018 Nov 27.

Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Sevilla, Prof. García González 2, Sevilla, 41012, Spain.

A new species of Trichuris (Nematoda: Trichuridae) is described from the capybara, Hydrochoeris hydrochaeris (Rodentia: Caviidae), from two localities of Corrientes Province, based on morphological characteristics and ITS1 and ITS2 of nuclear rDNA region sequences. This species present morphological differences with 28 species of the genus described from North and South American rodents. Also, the new species is molecularly characterized and differentiated from those species from Muridae, Cricetidae and Myocastoridae rodents recorded from North and South America, Europe and Africa. Read More

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November 2018
4 Reads

Molecular detection and quantification of slug parasitic nematodes from the soil and their hosts.

J Invertebr Pathol 2018 Nov 27. Epub 2018 Nov 27.

Instituto de Ciencias de la Vid y del Vino (CSIC-Universidad de La Rioja-Gobierno de La Rioja), Finca La Grajera, Ctra. de Burgos Km. 6, 26007 Logroño (Spain). Electronic address:

Terrestrial gastropod molluscs are widely distributed and are well known as pests of many types of plants that are notoriously difficult to control. Many species of nematodes are able to parasitize land snails and slugs, but few of them are lethal to their host. Species and/or populations of mollusc-parasitic nematodes (MPNs) that kill their hosts are promising for biological control purposes. Read More

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November 2018
3 Reads

Nematicidal Activity of the Essential Oil of Three Varieties of Tagetes minuta from Argentina.

Nat Prod Commun 2017 May;12(5):705-707

Essential oils composition of three Tagetes minuta varieties and a wild population (WP) from Argentina and their in vitro and in vivo nematicidal activity against root-knot nematode, Meloidogynejavanica, are described. All T. minuta EOs tested were very active against nematode juveniles (J2), but the strongest nematicidal effects were exhibited by the TmV3 variety oil, characterized by a high content of (E)-ocimenone. Read More

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Coinvasion by the ladybird Harmonia axyridis (Coleoptera: Coccinellidae) and its parasites, Hesperomyces virescens (Ascomycota: Laboulbeniales) and Parasitylenchus bifurcatus (Nematoda: Tylenchida, Allantonematidae), in the Caucasus.

PLoS One 2018 29;13(11):e0202841. Epub 2018 Nov 29.

A. N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia.

The study of parasites in recently established populations of invasive species can shed light on the sources of invasion and possible indirect interactions between the alien species and native ones. We studied parasites of the global invader Harmonia axyridis (Coleoptera: Coccinellidae) in the Caucasus. In 2012, the first established population of Ha. Read More

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November 2018
2 Reads

Remodeling of the endoplasmic reticulum in C. elegans oocytes is regulated by CGH-1.

Genesis 2018 Nov 29:e23267. Epub 2018 Nov 29.

Biology Department, Central Michigan University, Mount Pleasant, MI.

A key aspect of development in all metazoans is remodeling at the cellular level. During the development of gametes, remodeling occurs throughout the germ line. When C. Read More

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November 2018

Experimental habitat fragmentation disrupts nematode infections in Australian skinks.

Ecology 2018 Nov 29. Epub 2018 Nov 29.

Department of Ecology and Evolutionary Biology, University of Colorado at Boulder, Boulder, Colorado, 80309-0334, USA.

Habitat conversion and fragmentation threaten biodiversity and disrupt species interactions. While parasites are recognized as ecologically important, the impacts of fragmentation on parasitism are poorly understood relative to other species interactions. This lack of understanding is in part due to confounding landscape factors that accompany fragmentation. Read More

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November 2018

Environmental gradients and the evolution of tri-trophic interactions.

Ecol Lett 2018 Nov 28. Epub 2018 Nov 28.

Functional Ecology Laboratory, Institute of Biology, University of Neuchâtel, rue Emile Argand 11, 2000, Neuchâtel, Switzerland.

Long-standing theory predicts herbivores and predators should drive selection for increased plant defences, such as the specific production of volatile organic compounds for attracting predators near the site of damage. Along elevation gradients, a general pattern is that herbivores and predators are abundant at low elevation and progressively diminish at higher elevations. To determine whether plant adaptation along such a gradient influences top-down control of herbivores, we manipulated soil predatory nematodes, root herbivore pressure and plant ecotypes in a reciprocal transplant experiment. Read More

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November 2018
6 Reads

Social living simultaneously increases infection risk and decreases the cost of infection.

Proc Biol Sci 2018 Nov 28;285(1892). Epub 2018 Nov 28.

Odum School of Ecology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.

Elevated parasite infection risk is considered to be a near-universal cost of social living. However, living in groups may also provide benefits that reduce the negative impacts of infection. These potential 'tolerance' benefits of living socially are theoretically possible, but have rarely been described. Read More

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November 2018
1 Read

Molecular and morphological characterization of Paurodontoides siddiqii n. sp. (Nematoda: Hexatylina, Sphaerulariidae) associated with bark samples of Pinus eldarica from western Iran.

J Helminthol 2018 Nov 29:1-8. Epub 2018 Nov 29.

Department of Plant Protection,College of Agriculture and Natural Resources, University of Tehran,Karaj,Iran.

A new species of Paurodontoides, P. siddiqii n. sp. Read More

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November 2018

A transcriptomic snapshot of early molecular communication between Pasteuria penetrans and Meloidogyne incognita.

BMC Genomics 2018 Nov 29;19(1):850. Epub 2018 Nov 29.

Division of Nematology, ICAR-Indian Agricultural Research Institute, New Delhi, India.

Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops. Pasteuria penetrans is a hyperparasitic bacterium capable of suppressing the nematode reproduction, and represents a typical coevolved pathogen-hyperparasite system. Attachment of Pasteuria endospores to the cuticle of second-stage nematode juveniles is the first and pivotal step in the bacterial infection. Read More

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November 2018

Description of Drilocephalobus moldavicus Lisetskaya, 1968 (Rhabditida: Osstellidae) from Kelso Dunes, Mojave National Preserve, California, USA.

Zootaxa 2018 Nov 8;4514(3):438-444. Epub 2018 Nov 8.

Department of Zoology, Swedish Museum of Natural History, Box 50007, SE-104 05 Stockholm, Sweden.

Specimens of Drilocephalobus moldavicus are described from the Kelso Dunes area, Mojave National Preserve, southern California. This is the first record of the genus in North America. The specimens of this population are characterized by a body length of 322-417 µm in females and 403 µm in the male; cuticle finely annulated; lateral field with five incisures, extending to phasmid and two incisures extending almost to tail terminus in both sexes; lip region helmet-shaped, offset from body contour; lips amalgamated; stoma with thin walls lacking sclerotizations; pharynx without distinct divisions, cylindrical, widening slightly at about 1/3 of its length and basally, without valves; spermatheca 14-19 µm long; postvulval uterine sac 25-27 µm long; spicules 23 µm long; and female tail conoid-elongate with rounded terminus. Read More

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November 2018

Two new species of Xyalidae (Monhysterida, Nematoda) from the East China Sea.

Zootaxa 2018 Nov 9;4514(4):583-592. Epub 2018 Nov 9.

College of Life Science, Liaocheng University, Liaocheng, 252059, P.R. China. 2College of Life Science, Shandong Normal University, Jinan, 250014, P.R. China..

Two new free-living nematode species of the family Xyalidae Chitwood, 1951 found in the East China Sea are described. Daptonema donghaiensis sp. nov. Read More

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November 2018
3 Reads

One new species and one new record of the species of the family Comesomatidae (Nematoda: Chromadorida) from the South China Sea.

Zootaxa 2018 Oct 23;4504(1):119-127. Epub 2018 Oct 23.

College of Life Sciences, Liaocheng University, 1 Hunan Road, Liaocheng 252059, P. R. China.

One new and one known species of the family Comesomatidae were collected from marine sediments in the South China Sea. Cervonema longispicula sp. nov. Read More

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October 2018

Description of Enterobius (Colobenterobius) emodensis sp. n. (Nematoda: Oxyuridae) collected from Central Himalayan langur, Semnopithecus schistaceus, in Uttarakhand, India.

Zootaxa 2018 Nov 5;4514(1):65-76. Epub 2018 Nov 5.

Department of Biomedicine / Department of Infectious Disease Control, Faculty of Medicine, Oita University, Hasama, Yufu, Oita 879-5593, Japan..

A new pinworm species, Enterobius (Colobenterobius) emodensis sp. n. (Nematoda: Oxyuridae) is described from the Central Himalayan langur, Semnopithecus schistaceus, in Mandal Valley, Chamoli District, Uttarakhand, India, based on mature and immature adults and fourth-stage larvae. Read More

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November 2018

Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans.

Lab Chip 2018 Nov 28. Epub 2018 Nov 28.

Laboratory of Microsystems, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

The nematode Caenorhabditis elegans is increasingly used as a model for human biology. However, in vivo culturing platforms for C. elegans allowing high-content phenotyping during their life cycle in an automated fashion are lacking so far. Read More

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November 2018

Endoparasites of Jungle Cats () and Their Pathologic Lesions.

Iran J Parasitol 2018 Jul-Sep;13(3):480-485

Dept. of Pathology, Babol Branch, Islamic Azad University, Babol, Iran.

Background: The jungle cats () are native to Asia, and found in Iran. Although north of Iran has a wide distribution of jungle cats, there is not any data about prevalence of parasitic infections in the population of these cats.

Methods: From 2012 to 2015, seven specimens of the wild jungle cat () from north of Iran, Mazandaran Province, northern Iran were collected and examined for their endoparasites and pathological lesions which were caused by the parasites. Read More

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November 2018

Web-Based Interfaces for Virtual Neuron Model Definition, Network Configuration, Behavioral Experiment Definition and Experiment Results Visualization.

Front Neuroinform 2018 13;12:80. Epub 2018 Nov 13.

Bio-Inspired Electronics and Reconfigurable Computing (BIRC) Research Group, Electrical & Electronic Engineering Department, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.

The platform targets the complete virtualization of the nematode , and its environment. This paper presents a suite of unified web-based Graphical User Interfaces (GUIs) as the main user interaction point, and discusses their underlying technologies and methods. The user-friendly features of this tool suite enable users to graphically create neuron and network models, and behavioral experiments, without requiring knowledge of domain-specific computer-science tools. Read More

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November 2018

A cysteine protease-like domain enhances the cytotoxic effects of the toxin PaTox.

J Biol Chem 2018 Nov 26. Epub 2018 Nov 26.

Institute of Pharmacology and Toxicology, University of Freiburg, Germany.

The nematode mutualistic bacterium produces a large virulence-associated multifunctional protein toxin named PaTox. A glycosyltransferase domain and a deamidase domain of this large toxin function as effectors that specifically target host Rho GTPases and heterotrimeric G proteins, respectively. Modification of these intracellular regulators results in toxicity toward insects and mammalian cells. Read More

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November 2018
4 Reads

100 Questions in Livestock Helminthology Research.

Trends Parasitol 2018 Nov 23. Epub 2018 Nov 23.

Laboratory for Parasitology, Faculty of Veterinary Medicine, Ghent University, B9820 Merelbeke, Belgium.

An elicitation exercise was conducted to collect and identify pressing questions concerning the study of helminths in livestock, to help guide research priorities. Questions were invited from the research community in an inclusive way. Of 385 questions submitted, 100 were chosen by online vote, with priority given to open questions in important areas that are specific enough to permit investigation within a focused project or programme of research. Read More

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November 2018
3 Reads

Exploring the homolog of a novel proinflammatory microfilarial sheath protein (MfP) of Wuchereria bancrofti in the adult-stage bovine filarial parasite Setaria cervi.

J Helminthol 2018 Nov 27:1-6. Epub 2018 Nov 27.

Parasitology Laboratory,Department of Zoology (Centre for Advanced Studies),Visva-Bharati University,Santiniketan-731 235,India.

A novel microfilarial sheath protein (MfP) of the human filarial parasite Wuchereria bancrofti and its proinflammatory activity on host macrophages were identified recently. MfP is a homolog of the nematode bestrophin-9 superfamily that acts as a ligand of macrophage Toll-like receptor 4 (TLR4) to induce inflammation through NF-κB activation. Therefore, the presence and functional implication of this novel protein in adult-stage parasites were open questions to answer. Read More

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November 2018
1 Read

The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans.

Exp Gerontol 2018 Nov 23. Epub 2018 Nov 23.

School of Life Science and Techonology, Tongji University, Shanghai 200092, China. Electronic address:

As a traditional herbal medicine, the clinical efficacy of Ganoderma lucidum (G. lucidum, also known as Lingzhi in China) has been proved by clinical research and a large number of animal experiments. However, its pharmacological mechanism is not clear. Read More

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November 2018
5 Reads

Dermatitis caused by autochthonous Cercopithifilaria bainae from a dog in Florida, USA: clinical, histological and parasitological diagnosis and treatment.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA.

Background: Cercopithifilaria bainae is a tick-vectored filarioid nematode associated with erythematous dermatitis in dogs. It has not been reported previously in the United States.

Hypothesis/objective: To describe clinical, histological and parasitological diagnosis and treatment of C. Read More

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November 2018

Infant Growth Faltering Linked to Subclinical Mastitis, Maternal Fecal-Oral Contamination and Breastfeeding Practices.

Matern Child Nutr 2018 Nov 25:e12756. Epub 2018 Nov 25.

School of Human Nutrition, McGill University, Ste-Anne de Bellevue, QC, Canada.

Infant growth faltering occurs in breastfed infants < 6 months of age. The possibility that maternal health status contributes to this growth faltering is underexplored. We investigated whether 1) subclinical mastitis (SCM), an asymptomatic inflammation of the breast, 2) maternal intestinal nematode and protozoan infections, indicators of fecal-oral contamination or 3) poor breastfeeding practices increased the odds of stunting (LAZ < -2SD), underweight (WAZ < -2SD) or low head circumference (HCAZ < -2SD) in breastfed infants in rural indigenous communities in Guatemala. Read More

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November 2018
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Deep amplicon sequencing as a powerful new tool to screen for sequence polymorphisms associated with anthelmintic resistance in parasitic nematode populations.

Int J Parasitol 2018 Nov 22. Epub 2018 Nov 22.

Department of Comparative Biology and Experimental Medicine, University of Calgary Faculty of Veterinary Medicine, Calgary, Alberta, Canada. Electronic address:

Parasitic gastrointestinal nematodes contribute to significant human morbidity and cause billions of dollars per year in lost agricultural production. Control is dependent on the use of anthelmintic drugs which, in the case of livestock parasites, is severely compromised by the widespread development of drug resistance. There are now concerns regarding the emergence of anthelmintic resistance in parasitic nematodes of humans in response to the selection pressure resulting from mass drug administration programs. Read More

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November 2018
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Host-specific signatures of the cell wall changes induced by the plant parasitic nematode, Meloidogyne incognita.

Sci Rep 2018 Nov 23;8(1):17302. Epub 2018 Nov 23.

Centre for Plant Sciences, Faculty of Biological Sciences, University of Leeds, LS2 9JT, Leeds, United Kingdom.

Root-knot nematodes (Meloidogyne spp.) are an important group of plant parasitic nematodes that induce within host plant roots unique feeding site structures, termed giant cells, which supply nutrient flow to the nematode. A comparative in situ analysis of cell wall polysaccharides in the giant cells of three host species (Arabidopsis, maize and aduki bean) infected with Meloidogyne incognita has been carried out. Read More

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November 2018
7 Reads

Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.

J Steroid Biochem Mol Biol 2018 Nov 20. Epub 2018 Nov 20.

Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Czech Republic; Laboratory of Cancer Biology and Genetics, Czech Republic; Gamma Delta T Cell Laboratory, Czech Republic.

In higher metazoans, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor adaptors NCoA, which are absent in lower metazoans. The Nine amino acid TransActivation Domain, 9aaTAD, was reported for a large number of the transcription activators that recruit general mediators of transcription. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor of nematode C. Read More

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November 2018
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N-ϒ-(L-Glutamyl)-L-Selenomethionine Inhibits Fat Storage via the Stearoyl-CoA Desaturases FAT-6 and FAT-7 and the Selenoprotein TRXR-1 in Caenorhabditis elegans.

Mol Nutr Food Res 2018 Nov 23:e1800784. Epub 2018 Nov 23.

C.-H. Chang, H. X.-Q. Liao, V. H.-C. Liao, Department of Bioenvironmental Systems Engineering, National Taiwan University, No. 1 Roosevelt Road, Sec. 4, Taipei, 106, Taiwan.

Scope: Selenium is an important nutrient for human health. The influence of dietary selenium on lipid metabolism remains largely unknown. We investigated N-γ-(L-Glutamyl)-L-selenomethionine (Glu-SeMet) on inhibition of fat accumulation and its underlying mechanisms in the nematode Caenorhabditis elegans. Read More

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November 2018
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