8,778 results match your criteria Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia[Journal]


[Pharmacological treatment of overactive bladder in elderly patients].

Semergen 2019 Apr 17. Epub 2019 Apr 17.

Centro de Salud Integrado Alto Palancia, Segorbe, Castellón, España; Grupo de Trabajo de Urología (Nefrología y Vías Urinarias) de SEMERGEN.

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http://dx.doi.org/10.1016/j.semerg.2019.02.009DOI Listing

[Positioning for the management of arterial hypertension in Primary Care from the critical analysis of the American (2017) and European (2018) guidelines. Spanish Society of Primary Care Physicians (SEMERGEN)].

Semergen 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España.

The Scientific Societies of Primary Care, being the area in which there is a considerable prevalence of Arterial Hypertension (AHT), need to periodically evaluate the international guidelines for its management. This is particularly relevant when disparate guidelines make it difficult to make decisions in daily clinical practice. The present document has as its aim to analyse the changes and new developments proposed in the guidelines of the American College of Cardiology and the American Heart Association (ACC/AHA 2017), as well as in the guidelines of the European Society of Cardiology and European Society of Hypertension (ESC/ESH 2018). Read More

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http://dx.doi.org/10.1016/j.semerg.2019.02.003DOI Listing

Pediatric Patients With Steroid-Sensitive Nephrotic Syndrome Have Higher Expression of T Regulatory Lymphocytes in Comparison to Steroid-Resistant Disease.

Front Pediatr 2019 2;7:114. Epub 2019 Apr 2.

Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

Idiopathic nephrotic syndrome (INS) is classified according to the response to drug therapy in steroid-sensitive (SS), steroid-dependent (SD), and steroid-resistant (SR) categories. Previous studies showed changes in inflammatory activity of subpopulations of lymphocytes in INS. This study aimed to compare SS and SR patients in regard to subpopulations of leukocytes, profile of regulatory lymphocytes, and migratory activity of lymphocyte subpopulations. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00114/
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http://dx.doi.org/10.3389/fped.2019.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455073PMC
April 2019
1 Read

Sclerosing encapsulating peritonitis: imaging findings in an uncommon entity.

Radiologia 2019 Apr 12. Epub 2019 Apr 12.

Servicio de Diagnóstico por Imágenes, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objectives: To describe the most characteristic imaging findings for sclerosing encapsulating peritonitis, with an emphasis on the computed tomography findings.

Conclusion: The incidence of sclerosing encapsulating peritonitis is low. The pathophysiology of this condition is unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00338338193003
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http://dx.doi.org/10.1016/j.rx.2019.02.005DOI Listing
April 2019
1 Read

[Renal failure in the medicolegal evaluation of civil invalidity and social security disability (INPS)].

G Ital Nefrol 2019 Apr;36(2)

Medico specialista in medicina legale, medico convenzionato esterni presso il Centro Medico Legale (CML) INPS di Siena.

After a quick description of the anatomopathology and physiopathology of renal failure, the Authors delve into the problem of assessing its medicolegal aspects in the fields of civil invalidity and social security. In Italy, civil invalidity involves protecting the psychological and physical welfare of the disabled, as sanctioned by law 118 of 1971; this law protects all citizens with a debilitating condition, including those who do not work or are not of working age. A disabled person is someone who, if of working age (between 18 and retirement) has a reduction of more than ⅓ (34%) of their general work capacity; if under or over the retirement age, they have a persistent difficulty in carrying out age-appropriate functions and tasks. Read More

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[Psychological Assessment of a sample of women with ADPKD: quality of life, body image, anxiety and depression].

G Ital Nefrol 2019 Apr;36(2)

Primario Servizio di Psicologia Clinica e della Salute, IRCCS Ospedale San Raffaele, Milano, Italia; Università Vita Salute San Raffale, Milano, Italia.

Introduction: The Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a chronic renal disease that has not yet been the subject of psychological research. There are only a few studies related to the consequences and complications of this pathology on female patients, although women affected by this disease present serious problems.

Aim: The purpose of this study is to perform a psychological assessment (quality of life, anxiety, depression, body image) on a sample of 37 women with ADPKD. Read More

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April 2019
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[Waiting time on dialysis for active access to renal transplantation: a multicenter cross-sectional study in Lombardy].

G Ital Nefrol 2019 Apr;36(2)

MD, UO Nefrologia e Dialisi, ASST Fatebenefratelli e Oftalmico, Milano, Italia.

Background: The amount of time spent in dialysis waiting for a renal transplantation significantly affects its outcome. Hence, the timely planning of patients' transplant evaluation is crucial. According to data from the Nord Italia Transplant program (NITp), the average waiting time between the beginning of dialysis and the admission to the regional transplant waiting list in Lombardy is 20. Read More

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[Carnitin-Palmitoyl Transferase type 2 deficiency: a rare cause of acute renal failure due to rhabdomyolysis].

G Ital Nefrol 2019 Apr;36(2)

UOSVD di Nefrologia e Dialisi ASL Bari. Sede Direzionale: Osp. "S. Maria degli Angeli" Putignano.

Fatty acid oxidation disorders are inborn errors of metabolism. One of the possible alterations involves the failure of the carnitin-based transport of long-chain fatty acids into the mitochondria, necessary for muscle metabolism in case of prolonged physical exertion. Three kinds of Carnitin-Palmitoyl Transferase type 2 (CPT2) deficiency have been described: a myopathic form, a severe infantile form and a neonatal form. Read More

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April 2019
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[Infected hepatic cyst in ADPKD patient in peritoneal dialysis].

G Ital Nefrol 2019 Apr;36(2)

U.O. Nefrologia, Università degli Studi della Campania, "Luigi Vanvitelli", Napoli, Italia.

Renal and hepatic cysts infections are among the most important infectious complications of ADPKD and often require hospitalization. Liver cysts are even more complex than renal cysts and their diagnosis and treatment are quite controversial. We report the case of a 58-year-old patient with ADPKD undergoing peritoneal dialysis treatment. Read More

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[HELLP syndrome and hemolytic uremic syndrome during pregnancy: two disease entities, same causation. Case report and literature review].

G Ital Nefrol 2019 Apr;36(2)

Centro per la Cura e lo Studio della Sindrome Emolitico-Uremica. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano.

Thrombotic microangiopathies (TMA) are a group of diseases that can complicate pregnancy and threaten the lives of both the mother and the fetus. Several conditions can lead to TMA, including thrombotic thrombocytopenic purpura (TTP), HELLP syndrome and hemolytic uremic syndrome (HUS). We describe the case of a 39-year-old woman who presented a HELLP syndrome in the immediate postpartum period. Read More

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April 2019
3 Reads

[POEMS Syndrome: Nosographic classification and considerations on a clinical case].

G Ital Nefrol 2019 Apr;36(2)

U.O.C. di Nefrologia e Dialisi, Ospedale "Maggiore" Modica.

POEMS syndrome is a rare multisystemic disease characterised by the coexistence of two main symptoms, polyneuropathy and monoclonal gammopathy, associated with minor symptoms such as organomegaly, endocrinopathy, and skin changes. We describe a patient who presented with symptoms and signs fulfilling the criteria of POEMS. We have carried out a literature review with particular emphasis on its demographic and polymorphic clinical features. Read More

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April 2019
2 Reads

[The new frontier in endovascular treatment of arteriovenous fistula stenosis: the role of ultrasound-guided percutaneous transluminal angioplasty].

G Ital Nefrol 2019 Apr;36(2)

UOC di Nefrologia e Dialisi, P.O. "San Giovanni di Dio", Agrigento, Italia.

Native arteriovenous fistula is the preferred vascular access because of it does not usually cause infections and seems to be closely related with prolonged patient survival, compared to prosthetic grafts and central venous catheters; it also is cost effective. Venous stenosis is one of the main causes of AVF failure. It is caused by a number of upstream and downstream events. Read More

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April 2019
1 Read

[Doctor-Patient communication].

G Ital Nefrol 2019 Apr;36(2)

UOC Nefrologia e Dialisi, Ospedale San Giovanni di Dio, Azienda Sanitaria, Agrigento.

The Doctor-Patient relationship is of fundamental importance in the field of care and continues to undergo profound transformations. In ancient times the doctor was "authoritarian": the patient was considered a passive element, incapable of understanding, knowing and acting for his own health. The doctor then became a "paternalistic" figure and it is only recently that the patient has become a responsible subject who interacts with the doctor in the definition and evaluation of every health intervention. Read More

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[Choice and management of anticoagulation during CRRT].

G Ital Nefrol 2019 Apr;36(2)

U.O. Nefrologia Dialisi e Ipertensione, Policlinico S.Orsola-Malpighi, Bologna, Italia.

Continuous renal replacement therapies (CRRT) are widely used in the treatment of acute kidney injury. Several causes, related to the treatment itself or to the patient's condition, determine the coagulation of the extracorporeal circuit. These interruptions (or down-time) have a negative impact on the effectiveness of the treatment in terms of solute clearance and fluid balance. Read More

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April 2019
2 Reads

[Extracorporeal therapy in sepsis].

G Ital Nefrol 2019 Apr;36(2)

Struttura Complessa Universitaria di Nefrologia e Dialisi - CMID, Ospedale San Giovanni Bosco, ASL Città di Torino, Torino.

Acute renal injury (AKI) occurs in 19% of patients with sepsis, 23% of those with severe sepsis and up to 50% of patients with septic shock. AKI represents an independent prognostic factor of mortality (about 45%); epidemiological studies have pointed out that the onset of AKI in sepsis (S-AKI) correlates with an unfavourable outcome, reaching a mortality of 75%. Over the years, efforts have been made to prevent and treat "low flow" hemodynamic damage resulting from shock by increasing renal blood flow, improving cardiac output and perfusion pressure. Read More

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April 2019
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[Differential diagnosis of acute kidney injury in critically ill patients: the nephrologist's role in identifying the different causes of parenchymal damage].

G Ital Nefrol 2019 Apr;36(2)

SC Nefrologia e Dialisi, ASO S.Croce e Carle, Cuneo.

The management of acute kidney injury in the critical area is complex and necessarily multidisciplinary, but the nephrologist should maintain a pivotal role, both in terms of diagnosis and of indication, prescription and management of extracorporeal replacement therapy. The most frequent causes of AKI in the critically ill patients are correlated to sepsis and major surgery, but the incidence of different causes, of strict nephrological relevance, is probably higher than the estimate. Nephrologists have the competence to evaluate data relating to renal functions, urinary electrolytes, urinary sediment, and to identify which specific examinations can be useful to define the cause of AKI. Read More

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April 2019
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[The management of antibiotic therapy in critically ill patients with AKI: between underdosing and toxicity].

G Ital Nefrol 2019 Apr;36(2)

SC Nefrologia e Dialisi, ASO S.Croce e Carle, Cuneo.

Changes in microbiology and dialysis techniques in intensive care have made the use of antibiotics on nephropathic patients more complex. Several recent studies have modified our knowledge about the use of antibiotics in the care of critically ill patients, highlighting the frequency of their inappropriate use: both underdosing, risking low efficacy, and overdosing, with an increase in toxicity. Kidneys, organs devoted to excretion and metabolism, are a potential target of pharmacological toxicity. Read More

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[Is apheresis still a useful tool in the treatment of nephrological diseases?]

Authors:
Antonio Santoro

G Ital Nefrol 2019 Apr;36(2)

Scuola di Specializzazione in Nefrologia, Università degli Studi di Bologna, Policlinico S.Orsola-Malpighi.

Therapeutic apheresis is by now a century-old extracorporeal procedure, but it is still very much relevant thanks to advances in medical device technology. In addition to the classic plasma exchange, we now have double filtration techniques, plasma absorption, immunoadsorption, leuko and cyto-apheresis, LDL apheresis. The application of these highly selective techniques has opened up new perspectives in the treatment of various nephrological diseases. Read More

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Is SPPB useful as a screening method of functional capacity in patients with advanced chronic kidney disease?

Nefrologia 2019 Apr 7. Epub 2019 Apr 7.

Unidad ERCA, Servicio de Nefrología H.U. de la Princesa, Madrid, España. Electronic address:

Introduction And Objective: One of the consequences of the CKD, is the deterioration of the functional capacity, being able to manifest from different stages of the disease, until renal replacement therapy. The objective of this study was to determine the functionality of patients with CKD through functional capacity test, valuing the usefulness of the SPPB as a screening test in parallel.

Materials And Methods: It assessed the functional capacity of patients with CKD, using the test SPPB, 6MM, TUTG and STS. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.01.003DOI Listing
April 2019
1 Read

Brazilian chronic dialysis survey 2017.

J Bras Nefrol 2019 Mar 28. Epub 2019 Mar 28.

Sociedade Brasileira de Nefrologia, São Paulo, SP, Brasil.

Introduction: Having national data on chronic dialysis is essential in treatment planning.

Objective: To present data of the survey from the Brazilian Society of Nephrology on patients with chronic kidney disease on dialysis in July 2017.

Methods: Data was collected from dialysis units in Brazil. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0178DOI Listing
March 2019
1 Read

Usefulness of age-adjusted N-terminal prohormone of brain natriuretic peptide level as a diagnostic marker for incomplete Kawasaki disease in children.

Emergencias 2019 Abr;31(2):111-114

Sección de Neonatología, Unidad de Gestión Clínica de Pediatría, Hospital Universitario Puerta del Mar, Cádiz, España.

Objectives: The main objective was to assess the diagnostic usefulness of age-adjusted level of N-terminal prohormone of brain natriuretic peptide (NT-proBNP) as a diagnostic marker in children suspected of having incomplete Kawasaki disease (IKD). The secondary aim was to compare the diagnostic yield of NT-proBNP level with the yield of other markers currently recommended by the American Heart Association (AHA).

Material And Methods: Descriptive cross-sectional study of a case series of patients under the age of 14 years admitted with clinical suspicion of IKD between 2013 and 2017. Read More

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April 2019
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Corrigendum to "Effects of parathyroidectomy on the biology of bone tissue in patients with chronic kidney disease and secondary hyperparathyroidism" [Bone 121 (April 2019) 277-283].

Bone 2019 Apr 4;123:189-190. Epub 2019 Apr 4.

LIM 16 - Laboratorio de Fisiopatologia Renal, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Hospital Samaritano Americas Serviços Medicos, Sao Paulo, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.03.030DOI Listing
April 2019
1 Read

Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.

Endocrinol Diabetes Nutr 2019 Apr 4. Epub 2019 Apr 4.

Servicio de Nefrología, Hospital Universitario Insular, Las Palmas de Gran Canaria, España.

Introduction: Certain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain).

Patients And Methods: Polymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR]<30mL/min/1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
Publisher Site
http://dx.doi.org/10.1016/j.endinu.2019.01.006DOI Listing
April 2019
3 Reads

Burden, access, and disparities in kidney disease.

Nefrologia 2019 Apr 4. Epub 2019 Apr 4.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

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http://dx.doi.org/10.1016/j.nefro.2019.03.001DOI Listing

A case report of hereditary coproporphyria with neurological, haematological and renal involvement.

Gastroenterol Hepatol 2019 Apr 1. Epub 2019 Apr 1.

Servicio de Medicina Interna, Hospital San Cecilio, Granada, España.

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http://dx.doi.org/10.1016/j.gastrohep.2019.01.011DOI Listing

Onco-Nephrology: Cancer, chemotherapy and kidney.

Nefrologia 2019 Mar 28. Epub 2019 Mar 28.

Hospital Clinico Universitario, Valencia, España.

Chronic kidney disease (CKD), cancer and haematological diseases share areas of reciprocal influence. Cancer can affect the kidney either as glomerular lesions or as a result of the toxic effects of medication or radiation with acute (thrombotic microangiopathy, acute kidney injury, interstitial nephropathies among others) or chronic processes (worsening of CKD after nephrectomy due to renal cancer, interstitial fibrosis, hydroelectrolytic disorders). On the other hand, patients who require renal replacement therapy with dialysis and particularly with kidney transplantation are at high risk of onset of cancer due to the immunosuppression situation that they generate. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.10.016DOI Listing
March 2019
2 Reads

C5 Convertase Blockade in Membranoproliferative Glomerulonephritis: A Single-Arm Clinical Trial.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS; L. Sacco Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. Electronic address:

Rationale & Objective: Primary membranoproliferative glomerulonephritis (MPGN) is a rare glomerulopathy characterized by complement dysregulation. MPGN progresses rapidly to kidney failure when it is associated with nephrotic syndrome. We assessed the effects of C5 convertase blockade in patients with MPGN and terminal complement activation. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.046DOI Listing
March 2019
1 Read

User-centred design for developing e-Health system for renal patients at home (AppNephro).

Int J Med Inform 2019 May 22;125:47-54. Epub 2019 Feb 22.

Grupo de Ingeniería Biomédica, Universidad de Sevilla, Sevilla, 41092, Spain; Departamento de Ingeniería Telemática, Universidad de Sevilla, Spain.

Background: Despite the promising benefits of the e-Health approaches (including provide technology-based healthcare services to anyone, anytime, and anywhere), few solutions are adopted in daily practice. User acceptance is one of the major obstacles that hinder the success of technology approaches. End-users often stress misalignments among their problems and the solutions that technology systems aim to solve. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2019.02.007DOI Listing

Predicting urine output after kidney transplantation: development and internal validation of a nomogram for clinical use.

Int Braz J Urol 2019 Mar 25;45. Epub 2019 Mar 25.

Divisão de Urologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.

Purpose: To analyze pre-transplantation and early postoperative factors affecting post-transplantation urine output and develop a predictive nomogram.

Patients And Methods: Retrospective analysis of non-preemptive first transplanted adult patients between 2001-2016. The outcomes were hourly diuresis in mL/Kg in the 1st (UO1) and 8th (UO8) postoperative days (POD). Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0701DOI Listing
March 2019
1 Read

Review of alterations in gene expression and apoptotic pathways caused in nephrotoxicity induced by cisplatin.

Nefrologia 2019 Mar 22. Epub 2019 Mar 22.

Escuela Militar de Medicina, Centro Militar de Ciencias de la Salud, Secretaría de la Defensa Nacional, Ciudad de México, México. Electronic address:

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http://dx.doi.org/10.1016/j.nefro.2018.11.012DOI Listing
March 2019
1.442 Impact Factor

Hepatitis C and kidney transplant: The eradication time of the virus has arrived.

Nefrologia 2019 Mar 21. Epub 2019 Mar 21.

Instituto de Investigación, Hospital 12 de Octubre, Madrid, España. Electronic address:

Hepatitis C virus (HCV) infection is a factor that reduces the survival of the patient and the graft in renal transplant (RT). The availability of directly acting antivirals agents (DAAs), very effective and with an excellent safety profile, it allows eradicate HCV from patients with kidney disease, and this is a revolutionary radical change in the natural evolution of this infection, until now without effective and safe treatment for the contraindication use of interferon in kidney transplant patients. The efficiency of some DAAs for all genotypes, even in patients with renal insufficiency constitutes a huge contribution to eradicate HCV in the RT population independently the genotype, severity of kidney failure, progression of liver disease and previous anti HCV therapy. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.01.002DOI Listing

Renal failure in a 23-year-old man with ulcerative colitis treated with 5-aminosalicylate.

Rev Clin Esp 2019 Mar 20. Epub 2019 Mar 20.

Departamento de Nefrología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.

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http://dx.doi.org/10.1016/j.rce.2018.12.010DOI Listing
March 2019
1 Read

Increasing access to integrated ESKD care as part of universal health coverage.

Kidney Int 2019 Apr;95(4S):S1-S33

School of Medicine, Catholic University of Santisima Concepción, Concepcion, Chile.

The global nephrology community recognizes the need for a cohesive strategy to address the growing problem of end-stage kidney disease (ESKD). In March 2018, the International Society of Nephrology hosted a summit on integrated ESKD care, including 92 individuals from around the globe with diverse expertise and professional backgrounds. The attendees were from 41 countries, including 16 participants from 11 low- and lower-middle-income countries. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.005DOI Listing
April 2019
2 Reads
8.563 Impact Factor

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and risk for early-onset coronary artery disease.

Immunol Lett 2019 Apr 19;208:39-43. Epub 2019 Mar 19.

Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.

The nuclear-factor kappa-beta (NF-KB) is a driver of inflammation, and plays an important role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). Early-onset CAD is defined as a coronary ischaemic episode at an age ≤55 years, and in our population was strongly associated with male sex and smoking. Our aim was to determine whether common variants in three NF-KB genes were associated with early-onset CAD. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.007DOI Listing

Is it possible to predict the evolution of IgAN? Validation of the IgA nephropathy progression calculator and its relationship with MEST-C score in our population.

Nefrologia 2019 Mar 19. Epub 2019 Mar 19.

Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla, IDIVAL-REDINREN, Santander, Cantabria, España.

Introduction: IgA nephropathy (IgAN) is the most common and heterogeneous glomerular nephropathy. Several strategies have been used to determine the risk of progression to ESRD. We evaluate the prognostic significance and correlate the IgAN progression calculator (IgANPC) and the Oxford/MEST-C score in our population. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.10.015DOI Listing
March 2019
1 Read

Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis.

Phytomedicine 2019 Mar 13;58:152891. Epub 2019 Mar 13.

Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México. Circuito Exterior, Ciudad Universitaria. Delegación Coyoacán, Ciudad de México 04510, México.

Background: Swietenia humilis seeds are consumed in Mexico to treat type 2 diabetes; the antihyperglycemic effect of this species was previously demonstrated and related to the presence of tetranortriterpenoids of the mexicanolide class.

Purpose And Study Design: The present investigation was conducted to determine the mechanism of action of selected mexicanolides, including 2-hydroxy-destigloyl-6-deoxyswietenine acetate (1), methyl-2-hydroxy-3-β-tigloyloxy-1-oxomeliac-8(30)-enate (2) and humilinolide H (3), using in vivo experiments with hyperglycemic mice, and cell-based models.

Methods: Nicotinamide-streptozotocin hyperglycemic mice (50-130 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152891DOI Listing
March 2019
2 Reads

The Authors Reply.

Kidney Int Rep 2019 Mar 9;4(3):505-506. Epub 2019 Jan 9.

Servicio de Nefrología, Hospital Universitario Reina Sofía, Córdoba, Spain.

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http://dx.doi.org/10.1016/j.ekir.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409409PMC

Epidemiology of hyperkalemia in chronic kidney disease.

Nefrologia 2019 Mar 18. Epub 2019 Mar 18.

Servicio de Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España.

Background: Hyperkalaemia is a significant electrolyte imbalance in chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) have beneficial cardio-renal properties, although they can often cause hyperkalaemia.

Objective: To examine the prevalence of hyperkalaemia in CKD, identify factors associated with its appearance and the relationship between hyperkalaemia and mortality. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.11.011DOI Listing
March 2019
1 Read

Refractory ascites and graft dysfunction in early renal transplantation.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Serviço de Nefrologia e Transplantação Renal do Centro Hospitalar do Porto, Porto, Portugal.

The occurrence of ascites after Renal Transplant (RT) is infrequent, and may be a consequence of surgical or medical complications. Case report: 61 year-old, male, history of arterial hypertension, tongue carcinoma and alcoholic habits 12-20g/day. He had chronic kidney disease secondary to autosomal dominant polycystic kidney disease, without hepatic polycystic disease. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0175DOI Listing
March 2019
1 Read

[Prescribing of Non-Steroidal Anti-Inflammatory Drugs to Patients with Diabetes Mellitus in Portugal].

Acta Med Port 2019 Feb 28;32(2):119-125. Epub 2019 Feb 28.

Departamento de Nefrologia. Hospital Curry Cabral. Centro Hospitalar Universitário de Lisboa Central. Lisboa. Portugal.

Introduction: Portugal presents the highest incidence of stage 5 chronic kidney disease in Europe. It is speculated that a high consumption of non-steroidal anti-inflammatory drugs (NSAIDS) may contribute to this high incidence. Our aim was to characterize the prescription of non-steroidal anti-inflammatory drugs to patients with diabetes mellitus in Portugal. Read More

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http://dx.doi.org/10.20344/amp.10815DOI Listing
February 2019
1 Read

Impact of Glucose Exposure on Outcomes of a Nation-Wide Peritoneal Dialysis Cohort - Results of the BRAZPD II Cohort.

Front Physiol 2019 5;10:150. Epub 2019 Mar 5.

Programa de Pós-Graduação em Ciências da Saúde, Escola de Medicina, Curitiba, Brazil.

Data investigating the association of glucose exposure with technique failure and patient survival are limited to retrospective cohorts and was never tested outside Asia and considering the presence of competing risks. Prospective multicenter cohort study of incident peritoneal dialysis patients where the association of cumulative glucose exposure in 6, 12, and 24 months with patient survival and technique failure was tested using Cox regression analysis and competing risk analysis. We analyzed 4367 incident peritoneal dialysis patients with mean age 59. Read More

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http://dx.doi.org/10.3389/fphys.2019.00150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411763PMC

Fabry nephropathy. Role of nephrologist and clinical variables associated with the diagnosis.

Nefrologia 2019 Mar 16. Epub 2019 Mar 16.

Servicio de Terapia Intensiva, Hospital Dr. Enrique Erill de Escobar, Belén de Escobar, Buenos Aires, Argentina.

Background: The early detection of Fabry nephropathy is of interest to us. Its treatment is more effective in early stages. It has been studied by analysing molecular and tissue biomarkers. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.10.017DOI Listing
March 2019
1 Read

Renal Function Impairment in Kidney Transplantation: Importance of Early BK Virus Detection.

Transplant Proc 2019 Mar 30;51(2):350-352. Epub 2018 Dec 30.

Servicio de Nefrología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.

Background: BK virus allograft nephropathy is a major complication of kidney transplantation that markedly reduces graft survival (50% graft failure 24 months after being diagnosed). BK virus replication can occur at any time posttransplantation. Viruria detection is a signal of virus reactivation and precedes viremia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.12.016DOI Listing

Bile modulates secretion of incretins and insulin: a study on human extrahepatic cholestasis.

J Clin Endocrinol Metab 2019 Mar 15. Epub 2019 Mar 15.

Endocrinologia e Diabetologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italia.

Objective: changes in bile flow after bariatric surgery may beneficially modulate secretion of insulin and incretins leading to diabetes remission. However, the exact mechanism(s) involved are still unclear. We here propose an alternative method to investigate the relation between alterations in physiological bile flow and insulin and incretin secretion by studying the changes in gut-pancreatic function in extrahepatic cholestasis in non-diabetic humans. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02804DOI Listing
March 2019
4 Reads
6.209 Impact Factor

Calcium of 28mg/dL in patient of 4 days of life. Urgent treatment and follow-up.

Nefrologia 2019 Mar 8. Epub 2019 Mar 8.

Servicio de Pediatría, Hospital Materno-Infantil, Badajoz, España.

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http://dx.doi.org/10.1016/j.nefro.2018.12.041DOI Listing

Brachiobasilic arteriovenous fistula with superficialisation and transposition the basilic vein in a one stage surgical technique. Five years of single experience.

Nefrologia 2019 Mar 7. Epub 2019 Mar 7.

Servicio de Nefrología, Hospital Clínic; Unidad Funcional de Acceso Vascular, Barcelona, España.

Background: The basilic vein is a deep vein which usually requires superficialisation and surgical transposition.

Material And Methods: This is a retrospective study of 119 BBAVF-ST in patients with stage 5D chronic kidney disease who received an implant with a one-stage surgical technique (2011-2015). The percentage of primary (PP), assisted primary (APP) and secondary (SP) permeabilities were assessed, as well as the related complications. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.11.010DOI Listing
March 2019
2 Reads

Kidney transplant registries: How to optimise their utility?

Nefrologia 2019 Mar 5. Epub 2019 Mar 5.

Centro de Atención Primaria La Cuesta, La Laguna, Santa Cruz de Tenerife, España.

The scientific Registries (RE) in renal transplantation (Tx) are very useful since they allow us to identify risk factors in this population and facilitate contrasting the information with other national and international registries, contributing to establishing strategies which improve outcomes in terms of survival. They constitute an organised and planned system that uses observational methods and standardised systematic processes, including adjusted risk models, to essentially evaluate survival outcomes. The scientific RE are complemented with clinical trials providing scientific evidence, but inexcusably need adequate statistical analysis to generate reliable clinical data that contribute to optimising the prognosis of the transplant population. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.11.008DOI Listing

Envarsus, a novelty for transplant nephrologists: Observational retrospective study.

Nefrologia 2019 Mar 5. Epub 2019 Mar 5.

Área de Farmacia y Tecnología Farmacéutica, Departamento de Ingeniería, Universidad Miguel Hernández de Elche; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-Fundación FISABIO), Elche, Alicante, España.

The aim of this study was to evaluate the trough concentrations (Cp) and the tacrolimus dosage regimen after the conversion of Prograf or Advagraf to Envarsus (new pharmaceutical form with MeltDose technology that improves the absorption of fat-soluble drugs) in patients with stable renal transplantation, and their renal function. We selected stable renal transplant patients who were converted to Envarsus. Two periods were defined: Baseline and Conversion (Envarsus) and they were stratified according to the pharmaceutical form used in the Baseline period. Read More

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http://dx.doi.org/10.1016/j.nefro.2018.11.009DOI Listing
March 2019
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[Rhabdomyolysis and severe hypercalcemia. Report of one case].

Rev Med Chil 2019 ;147(1):125-129

Departamento de Nefrología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.4067/S0034-98872019000100125DOI Listing
March 2019
6 Reads