954 results match your criteria Nederlands Tijdschrift voor Geneeskunde [Journal]


Low-dose computed tomography for lung cancer screening in high-risk populations: a systematic review and economic evaluation.

Health Technol Assess 2018 Nov;22(69):1-276

Peninsula Technology Assessment Group (PenTAG), University of Exeter Medical School, Exeter, UK.

Background: Diagnosis of lung cancer frequently occurs in its later stages. Low-dose computed tomography (LDCT) could detect lung cancer early.

Objectives: To estimate the clinical effectiveness and cost-effectiveness of LDCT lung cancer screening in high-risk populations. Read More

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November 2018

Oral fosfomycin versus ciprofloxacin in women with E.coli febrile urinary tract infection, a double-blind placebo-controlled randomized controlled non-inferiority trial (FORECAST).

BMC Infect Dis 2018 Dec 5;18(1):626. Epub 2018 Dec 5.

University Medical Centre Utrecht, University of Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands.

Background: Febrile Urinary Tract Infection (FUTI) is frequently treated initially with intravenous antibiotics, followed by oral antibiotics guided by clinical response and bacterial susceptibility patterns. Due to increasing infection rates with multiresistant Enterobacteriaceae, antibiotic options for stepdown treatment decline and patients more frequently require continued intravenous antibiotic treatment for FUTI. Fosfomycin is an antibiotic with high bactericidal activity against Escherichia coli and current resistance rates are low in most countries. Read More

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December 2018

Pediatric total fractionated metanephrine. Age-related reference intervals in spot urine.

Minerva Pediatr 2018 Dec 3. Epub 2018 Dec 3.

Department of Laboratory Medicine and Pathology, Azienda USL of Modena, Modena, Italy.

Background: Sparse metanephrines reference intervals in pediatric populations are available and different study designs and technologies/ assays used in these studies lead to hardly transferable data from a laboratory to another. The objective of the study was to update pediatric reference intervals of total fractionated metanephrines in spot urine samples, using a commercial extraction kit run on a specific high pressure liquid chromatograph coupled with an electrochemical detector.

Methods: 452 spot pediatric urinary samples previously submitted to urinalysis were consecutively included in the study with the exclusion of children's samples with diagnosis or clinical suspicion of paraganglioma/pheochromocytoma, kidney diseases and arterial hypertension. Read More

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December 2018
2 Reads

Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study.

BMC Geriatr 2018 Nov 26;18(1):289. Epub 2018 Nov 26.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, PO Box 7057, 1007, MB, Amsterdam, the Netherlands.

Background: The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated protective factors for cognitive impairment in the oldest-old. The EMIF-AD 90+ Study aims to identify factors associated with resilience to cognitive impairment in the oldest-old. Read More

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November 2018
3 Reads

[Stronger feelings of loneliness among Moroccan and Turkish older adults in the Netherlands: A search for an explanation].

Tijdschr Gerontol Geriatr 2018 Dec 12;49(6):263-273. Epub 2018 Nov 12.

Nederlands Interdisciplinair Demografisch Instituut, Den Haag, Nederland.

The prevalence of loneliness among Turkish- and Moroccan-Dutch older adults is higher than among Dutch older adults of non-migrant origin. Two explanations may account for this difference. (1) The meaning of the concept may differ, or there is differential item functioning. Read More

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December 2018

Oral health among Dutch elite athletes prior to Rio 2016.

Phys Sportsmed 2018 Nov 8:1-7. Epub 2018 Nov 8.

a Department of Oral & Maxillofacial Surgery , Special Dental Care and Orthodontics, Erasmus Medical Centre , Rotterdam , The Netherlands.

Objectives: Elite athletes are at high risk for poor oral health. A screening program to assess oral health and create dental awareness can improve oral health among elite athletes but has not been performed in the Netherlands before. We summarize the first results from such a screening conducted in Dutch elite athletes of the Nederlands Olympisch Committee*Nederlandse Sport Federatie (NOC*NSF, Dutch Olympic Committee). Read More

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November 2018

Efficacy of non-pharmacological interventions to treat malnutrition in older persons: A systematic review and meta-analysis. The SENATOR project ONTOP series and MaNuEL knowledge hub project.

Ageing Res Rev 2018 Nov 2;49:27-48. Epub 2018 Nov 2.

Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain.

Introduction: We aimed to perform a review of SRs of non-pharmacological interventions in older patients with well-defined malnutrition using relevant outcomes agreed by a broad panel of experts.

Methods: PubMed, Cochrane, EMBASE, and CINHAL databases were searched for SRs. Primary studies from those SRs were included. Read More

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November 2018
6 Reads

Fluoroscopy with MRA fusion image guidance in endovascular iliac artery interventions: study protocol for a randomized controlled trial (3DMR-Iliac-roadmapping study).

Trials 2018 Nov 1;19(1):603. Epub 2018 Nov 1.

Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, Groningen, The Netherlands.

Background: Endovascular iliac artery interventions rely on the use of two-dimensional digital subtraction angiographies with an iodinated contrast agent and ionizing radiation. The amount of iodinated contrast agent should be limited because of its potentially nephrotoxic effects. Three-dimensional (3D) image fusion requires registration of a preprocedural magnetic resonance angiogram (MRA) or computed tomography (CT) angiogram to a perprocedurally acquired cone-beam CT or two fluoroscopic orthogonal projections. Read More

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November 2018
1 Read

Transcriptome Analysis of a Spray Drying-Resistant Subpopulation Reveals a Zinc-Dependent Mechanism for Robustness in SK11.

Front Microbiol 2018 15;9:2418. Epub 2018 Oct 15.

Kluyver Centre for Genomics of Industrial Fermentation, Delft, Netherlands.

The viability of starter cultures is essential for an adequate contribution to the fermentation process and end-product. Therefore, robustness during processing and storage is an important characteristic of starter culture strains. For instance, during spray drying cells are exposed to heat and oxidative stress, generally resulting in loss of viability. Read More

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October 2018
1 Read

TRACE (Routine posTsuRgical Anesthesia visit to improve patient outComE): a prospective, multicenter, stepped-wedge, cluster-randomized interventional study.

Trials 2018 Oct 26;19(1):586. Epub 2018 Oct 26.

Department of Anesthesiology, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of complications. Until now, no studies have been performed on the impact of routine postsurgical anesthesia visits on the incidence of postoperative complications and mortality. Read More

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October 2018
3 Reads

Effects of the Namaste Care Family programme on quality of life of nursing home residents with advanced dementia and on family caregiving experiences: study protocol of a cluster-randomised controlled trial.

BMJ Open 2018 Oct 15;8(10):e025411. Epub 2018 Oct 15.

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.

Introduction: Quality of life of people with advanced dementia living in nursing homes is often suboptimal. Family caregivers can feel frustrated with limited contact with their relatives, which results in visits that are perceived as stressful and not very meaningful. Few psychosocial interventions are specifically developed for people with advanced dementia, and actively involve family caregivers or volunteers. Read More

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October 2018
1 Read

Tailored, Therapist-Guided Internet-Based Cognitive Behavioral Therapy Compared to Care as Usual for Patients With Rheumatoid Arthritis: Economic Evaluation of a Randomized Controlled Trial.

J Med Internet Res 2018 Oct 11;20(10):e260. Epub 2018 Oct 11.

Health, Medical and Neuropsychology Department, Institute of Psychology, Leiden University, Leiden, Netherlands.

Background: Internet-based cognitive behavioral therapy can aid patients with rheumatoid arthritis with elevated levels of distress to enhance their quality of life. However, implementation is currently lacking and there is little evidence available on the (cost-) effectiveness of different treatment strategies.

Objective: Cost-benefit ratios are necessary for informing stakeholders and motivating them to implement effective treatment strategies for improving health-related quality of life (HRQoL) of patients with rheumatoid arthritis. Read More

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October 2018
1 Read

Quality of life: fractionated stereotactic radiotherapy versus enucleation treatment in uveal melanoma patients.

Acta Ophthalmol 2018 Dec 3;96(8):841-848. Epub 2018 Oct 3.

Department of Ophthalmology, Erasmus University Medical Centre, Rotterdam, the Netherlands.

Purpose: To report the quality of life and visual functioning in uveal melanoma patients treated with enucleation or fractionated stereotactic radiation therapy (fSRT).

Methods: Uveal melanoma (UM) patients treated with fSRT (n = 65) or enucleation (n = 48) participated in this prospective study. Questionnaires to measure anxiety (State-Trait Anxiety Inventory), subjective distress (Impact of Event Scale) and quality of life (EORTC-QLQ-C30 and National Eye Institute Visual Function Questionnaire (VFQ-25)) were obtained before treatment and 2, 6, 12, 24, 36 and 48 months after treatment. Read More

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December 2018
1 Read

Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over.

BMC Endocr Disord 2018 Sep 19;18(1):67. Epub 2018 Sep 19.

Department of Gerontology and Geriatrics (C7-Q), Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

Background: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base. Read More

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September 2018
1 Read

Benefits and limitations of three-dimensional printing technology for ecological research.

BMC Ecol 2018 09 10;18(1):32. Epub 2018 Sep 10.

Integrative Ecology Lab, Center for Biodiversity, Department of Biology, Temple University, Philadelphia, PA, USA.

Background: Ecological research often involves sampling and manipulating non-model organisms that reside in heterogeneous environments. As such, ecologists often adapt techniques and ideas from industry and other scientific fields to design and build equipment, tools, and experimental contraptions custom-made for the ecological systems under study. Three-dimensional (3D) printing provides a way to rapidly produce identical and novel objects that could be used in ecological studies, yet ecologists have been slow to adopt this new technology. Read More

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September 2018

Robot assisted radical cystectomy versus open radical cystectomy in bladder cancer (RACE): study protocol of a non-randomized comparative effectiveness study.

BMC Cancer 2018 Sep 3;18(1):861. Epub 2018 Sep 3.

Departments of Operating Rooms and Health Evidence, Radboud university medical center, Geert Grooteplein Noord 21, 6500, HB, Nijmegen, The Netherlands.

Background: Despite the fact that the cost-effectiveness of robot-assisted radical cystectomy (RARC) is not yet proven, and open radical (ORC) cystectomy is recommended as the standard of care in patients with high-risk non-muscle-invasive and muscle-invasive bladder cancer, the use of RARC is still increasing. The objective of the current ongoing comparative effectiveness trial therefore is to study the (cost-)effectiveness of RARC compared to ORC, both in terms of objective (complication rates, oncological outcomes) and patient-reported (health-related quality of life) outcome measures.

Methods: This study is designed as a non-randomized, multicentre comparative effectiveness trial. Read More

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September 2018

Dose-response modeling of reactivating potency of oximes K027 and K203 against a direct acetylcholinesterase inhibitor in rat erythrocytes.

Food Chem Toxicol 2018 Nov 1;121:224-230. Epub 2018 Sep 1.

University of Belgrade, Faculty of Pharmacy, Department of Toxicology "Akademik Danilo Soldatović", Vojvode Stepe 450, 11221, Belgrade, Serbia. Electronic address:

Inhibition of acethylcholinesterase (AChE) as a key molecular event induced by organophosphate (OP) pesticides and nerve agents presents a human health concern. In efficacy testing of experimental oximes, potential antidotes in OP poisoning, reactivation of OP-inhibited AChE is used as specific endpoint. However, according to our best knowledge, so far oximes have not been quantitatively evaluated by comprehensive benchmark dose (BMD) approach, that would improve both identification and quantification of the effect and allow more rigorous comparison of efficacies. Read More

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November 2018
4 Reads

Follicle stimulating hormone versus clomiphene citrate in intrauterine insemination for unexplained subfertility: a randomized controlled trial.

Hum Reprod 2018 Oct;33(10):1866-1874

Centre for Reproductive Medicine, Academic Medical Centre, Meiberg dreef 9, 1105 AZ, Amsterdam, The Netherlands.

Study Question: Is FSH or clomiphene citrate (CC) the most effective stimulation regimen in terms of ongoing pregnancies in couples with unexplained subfertility undergoing IUI with adherence to strict cancellation criteria as a measure to reduce the number of multiple pregnancies?

Summary Answer: In IUI with adherence to strict cancellation criteria, ovarian stimulation with FSH is not superior to CC in terms of the cumulative ongoing pregnancy rate, and yields a similar, low multiple pregnancy rate.

What Is Already Known: FSH has been shown to result in higher pregnancy rates compared to CC, but at the cost of high multiple pregnancy rates. To reduce the risk of multiple pregnancy, new ovarian stimulation regimens have been suggested, these include strict cancellation criteria to limit the number of dominant follicles per cycle i. Read More

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October 2018

A novel probabilistic forecast system predicting anomalously warm 2018-2022 reinforcing the long-term global warming trend.

Nat Commun 2018 08 14;9(1):3024. Epub 2018 Aug 14.

Ocean and Earth Science, University of Southampton, Southampton, UK.

In a changing climate, there is an ever-increasing societal demand for accurate and reliable interannual predictions. Accurate and reliable interannual predictions of global temperatures are key for determining the regional climate change impacts that scale with global temperature, such as precipitation extremes, severe droughts, or intense hurricane activity, for instance. However, the chaotic nature of the climate system limits prediction accuracy on such timescales. Read More

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August 2018
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Improving empathy and self-efficacy in caregivers of persons with intellectual disabilities, using m-learning (HiSense APP-ID): study protocol for a randomized controlled trial.

Trials 2018 Jul 27;19(1):400. Epub 2018 Jul 27.

Stichting Ons Tweede Thuis, Hortensialaan 55A, 1431 VA, Aalsmeer, The Netherlands.

Background: A secure attachment with one or more caregivers is one of the most important predictors of cognitive development and emotional wellbeing. Persons with intellectual disabilities (ID) have extra need for secure relationships with primary caregivers but can find making connections difficult. This study aims to explore the effect of a non-invasive m-learning intervention on the empathy and self-efficacy of caregivers, in view of improving attachment relationships with persons with ID. Read More

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[The accuracy of patients' perceptions of the risks associated with localised prostate cancer treatments].

Ned Tijdschr Geneeskd 2018 Jun 7;162. Epub 2018 Jun 7.

Universitair Medisch Centrum Utrecht, Cancer Center, afd. Urologie, Utrecht.

Objective: To assess the accuracy of patients' perceptions of the risks associated with localised prostate cancer treatments (radical prostatectomy [RP], radiotherapy [RT], and active surveillance [AS]), and to identify correlates of misperceptions.

Patients And Methods: We used baseline data (questionnaires completed after treatment information was provided but before treatment) of 426 patients with newly diagnosed localised prostate cancer who participated (87% response rate) in a prospective, longitudinal, multicentre study. Patients' pretreatment perceptions of differences in adverse outcomes of treatments were compared to those based on the literature. Read More

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June 2018
4 Reads

[Medical training did not give survival advantage; life expectancy of Dutch medical professionals born between 1550 and 1909].

Ned Tijdschr Geneeskd 2018 Jul 6;162. Epub 2018 Jul 6.

Onafhankelijk onderzoeker, Hoogeveen.

Objective: To examine if, over a period of centuries, the Dutch medical establishment enjoyed a survival advantage over a population group with a comparable social background and level of education.

Design: Retrospective database research.

Method: We used documents which provided data on the births and deaths of 15,649 male and 659 female medical professionals and of 15,304 male clergy. Read More

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Use of monomeric and oligomeric flavanols in the dietary management of patients with type 2 diabetes mellitus and microalbuminuria (FLAVA trial): study protocol for a randomized controlled trial.

Trials 2018 Jul 16;19(1):379. Epub 2018 Jul 16.

Department of Internal Medicine, Section of Pharmacology, Vascular and Metabolic Diseases, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Background: Patients with type 2 diabetes mellitus (T2D) are prone to micro- and macro-vascular complications. Monomeric and oligomeric flavanols (MOF) isolated from grape seeds (Vitis vinifera) have been linked to improved endothelial function and vascular health. The aim of this study is to determine the effect of a daily supplementation of 200 mg MOF on renal endothelial function of patients with T2D and microalbuminuria. Read More

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July 2018
3 Reads

Distinctive facial features in idiopathic Moyamoya disease in Caucasians: a first systematic analysis.

PeerJ 2018 27;6:e4740. Epub 2018 Jun 27.

Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Nederlands.

Background: Craniofacial dysmorphic features are morphological changes of the face and skull which are associated with syndromic conditions. Moyamoya angiopathy is a rare cerebral vasculopathy that can be divided into Moyamoya syndrome, which is associated or secondary to other diseases, and into idiopathic Moyamoya disease. Facial dysmorphism has been described in rare genetic syndromes with associated Moyamoya syndrome. Read More

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June 2018
3 Reads

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers.

Angiogenesis 2018 Nov 27;21(4):823-836. Epub 2018 Jun 27.

Ocular Angiogenesis Group, Departments of Ophthalmology and Medical Biology, Amsterdam University Medical Centers, Academic Medical Center, Amsterdam, The Netherlands.

Tip cells, the leading cells of angiogenic sprouts, were identified in cultures of human umbilical vein endothelial cells (HUVECs) by using CD34 as a marker. Here, we show that tip cells are also present in primary human microvascular endothelial cells (hMVECs), a more relevant endothelial cell type for angiogenesis. By means of flow cytometry, immunocytochemistry, and qPCR, it is shown that endothelial cell cultures contain a dynamic population of CD34 cells with many hallmarks of tip cells, including filopodia-like extensions, elevated mRNA levels of known tip cell genes, and responsiveness to stimulation with VEGF and inhibition by DLL4. Read More

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November 2018
3 Reads

The immediate effect of a soft knee brace on dynamic knee instability in persons with knee osteoarthritis.

Rheumatology (Oxford) 2018 10;57(10):1735-1742

Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam Movement Sciences, Academic Medical Center, Amsterdam, The Netherlands.

Objectives: Wearing a soft knee brace has been shown to reduce self-reported knee instability in persons with knee OA. There is a need to assess whether a soft knee brace has a beneficial effect on objectively assessed dynamic knee instability as well. The aims of the study were to evaluate the effect of a soft knee brace on objectively assessed dynamic knee instability and to assess the difference in effect between a non-tight and a tight soft knee brace in persons with knee OA. Read More

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October 2018
3 Reads

Short-Term Effects of Imprisonment Length on Recidivism in the Netherlands.

Crime Delinq 2018 Jul 12;64(8):1057-1093. Epub 2017 Jan 12.

Nederlands Studiecentrum Criminaliteit en Rechtshandhaving, The Netherlands.

This article assesses the relationship between imprisonment length and recidivism. The data come from a unique longitudinal and nationwide study of Dutch prisoners, serving an average of 4.1 months of confinement ( = 1,467). Read More

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Hypertensive disorders of pregnancy and subsequent maternal cardiovascular health.

Eur J Epidemiol 2018 Aug 19;33(8):763-771. Epub 2018 May 19.

Department of Obstetrics and Gynaecology, Erasmus MC, Na 2918, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

To examine associations between hypertensive pregnancy disorders and maternal cardiovascular disease (CVD) in later life. We examined the associations between blood pressure (BP) in pregnancy, gestational hypertension (GH) and preeclampsia (PE) with cardiovascular measurements 6 years after index pregnancy among 4912 women participating in the Generation R Study, the Netherlands. BP, left ventricular mass (LV mass), aortic root diameter (AOD), left atrial diameter, fractional shortening, and carotid-femoral pulse wave velocity (PWV). Read More

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August 2018
1 Read

Stages of behavioural change after direct-to-consumer disease risk profiling: study protocol of two integrated controlled pragmatic trials.

Trials 2018 Apr 19;19(1):240. Epub 2018 Apr 19.

Department of Complex Genetics, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.

Background: The incidence and prevalence of chronic diseases have reached epidemic proportions during the last decades and are not expected to diminish. Chronic diseases increasingly affect younger individuals too, with over 40% of all deaths due to non-communicable diseases occurring before the age of 70. This has led to the development of information services aimed at preventive health care, such as Health Potential®. Read More

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Comparative Study Between Peristomal Patches in Patients with Definitive Tracheostomy.

Int Arch Otorhinolaryngol 2018 Apr 16;22(2):130-135. Epub 2017 Jun 16.

Department of Head and Neck Surgery and Oncology, Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, The Netherlands.

 To prevent or diminish pulmonary problems in laryngectomized patients, continuous use of a heat and moisture exchanger (HME) is recommended. Therefore, automatic speaking valves are also often combined with an HME to enable hands-free speech. In order to keep these devices in place, most commonly, peristomal patches are used. Read More

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Validation of [F]FLT as a perfusion-independent imaging biomarker of tumour response in EGFR-mutated NSCLC patients undergoing treatment with an EGFR tyrosine kinase inhibitor.

EJNMMI Res 2018 Mar 27;8(1):22. Epub 2018 Mar 27.

Department of Radiology & Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007, MB, Amsterdam, The Netherlands.

Background: 3'-Deoxy-3'-[F]fluorothymidine ([F]FLT) was proposed as an imaging biomarker for the assessment of in vivo cellular proliferation with positron emission tomography (PET). The current study aimed to validate [F]FLT as a perfusion-independent PET tracer, by gaining insight in the intra-tumoural relationship between [F]FLT uptake and perfusion in non-small cell lung cancer (NSCLC) patients undergoing treatment with a tyrosine kinase inhibitor (TKI). Six patients with metastatic NSCLC, having an activating epidermal growth factor receptor (EGFR) mutation, were included in this study. Read More

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Disentangling the effect of illness perceptions on health status in people with type 2 diabetes after an acute coronary event.

BMC Fam Pract 2018 Mar 2;19(1):35. Epub 2018 Mar 2.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Chronically ill patients such as people with type 2 diabetes develop perceptions of their illness, which will influence their coping behaviour. Perceptions are formed once a health threat has been recognised. Many people with type 2 diabetes suffer from multimorbidity, for example the combination with cardiovascular disease. Read More

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March 2018
2 Reads

NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related thrombosis.

BMC Pediatr 2018 02 23;18(1):84. Epub 2018 Feb 23.

Department of Pediatric Hematology, Sophia Children's Hospital Erasmus MC, Postbus 2060, 3015 CN, Rotterdam, the Netherlands.

Background: In critically ill (preterm) neonates, central venous catheters (CVCs) are increasingly used for administration of medication or parenteral nutrition. A serious complication, however, is the development of catheter-related thrombosis (CVC-thrombosis), which may resolve by itself or cause severe complications. Due to lack of evidence, management of neonatal CVC-thrombosis varies among neonatal intensive care units (NICUs). Read More

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February 2018
18 Reads

Phase-based treatment versus immediate trauma-focused treatment in patients with childhood trauma-related posttraumatic stress disorder: study protocol for a randomized controlled trial.

Trials 2018 Feb 22;19(1):138. Epub 2018 Feb 22.

Department of Social Dentistry and Behavioral Sciences, University of Amsterdam and Vrije Universiteit, Amsterdam, the Netherlands.

Background: The treatment of posttraumatic stress disorder (PTSD) related to a history of sexual and/or physical abuse in childhood is the subject of international debate, with some favouring a phase-based approach as their preferred treatment, while others argue for immediate trauma-focused treatment. A history of (chronic) traumatisation during childhood has been linked to the development of distinct symptoms that are often labelled as symptoms of complex PTSD. Many therapists associate the presence of symptoms of complex PTSD with a less favourable treatment prognosis. Read More

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February 2018
3 Reads

Prophylactic platelet transfusion prior to central venous catheter placement in patients with thrombocytopenia: study protocol for a randomised controlled trial.

Trials 2018 Feb 20;19(1):127. Epub 2018 Feb 20.

Department of Intensive Care Medicine, Academic Medical Centre, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

Background: Severe thrombocytopenia should be corrected by prophylactic platelet transfusion prior to central venous catheter (CVC) insertion, according to national and international guidelines. Even though correction is thought to prevent bleeding complications, evidence supporting the routine administration of prophylactic platelets is absent. Furthermore, platelet transfusion bears inherent risk. Read More

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February 2018
1 Read

[The use of scientific journals and professional periodicals by Dutch dental students].

Ned Tijdschr Tandheelkd 2018 Feb;125(2):89-95

In the present study, the extent to which dental students in Amsterdam, Groningen and Nijmegen consult scientific journals and professional periodicals was explored by means of a digital questionnaire. 333 dental students (20% response rate) participated in this study, 69% of whom had experience in conducting scientific research. 65% of the students had a subscription to a dental journal. Read More

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February 2018

The HYSTER study: the effect of intracervically administered terlipressin versus placebo on the number of gaseous emboli and fluid intravasation during hysteroscopic surgery: study protocol for a randomized controlled clinical trial.

Trials 2018 Feb 14;19(1):107. Epub 2018 Feb 14.

University of Amsterdam/AMC Hospital, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands.

Background: Transcervical resection of myoma or endometrium is a safe, hysteroscopic, minimally invasive procedure. However, intravasation of distension fluid is a common phenomenon during these procedures. In a previous study we observed venous gas emboli in almost every patient. Read More

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February 2018
2 Reads

[Hope-Simpson and shingles].

Ned Tijdschr Geneeskd 2018;162:D2158

Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap, Utrecht.

Dr Robert Edgar Hope-Simpson (1908-2003) was a British general practitioner, who has laid the foundation for unravelling the pathogenesis of shingles. At the beginning of the 20th century, both conditions were known to be related, but the precise relationship was unclear. It was assumed that chickenpox could originate after infection by both a person with shingles or someone with chickenpox, but that both diseases were caused by different viruses. Read More

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January 2018

[The conversation with the patient is essential for good pharmacotherapeutic care].

Tijdschr Gerontol Geriatr 2018 Apr;49(2):56-59

Centrum Gezondheidsbescherming, Rijkinstituut voor Volksgezondheid en Milieu, Postbus 1, 3720 BA, Bilthoven, Nederland.

Frail elderly with polypharmacy are at greater risk of preventable medication-related health damage. To improve medication safety, the healthcare field prepared, in consultation with the Dutch Health Care Inspectorate, a number of guidelines and standards containing conditions for safe prescribing. According to these standards the active involvement of patients by health care professionals is essential for good pharmacotherapeutic care. Read More

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April 2018
1 Read

Comparison of kQ factors measured with a water calorimeter in flattening filter free (FFF) and conventional flattening filter (cFF) photon beams.

Phys Med Biol 2018 Jan 25. Epub 2018 Jan 25.

Radiotherapy, Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, Noord-Holland, NETHERLANDS.

Recently flattening filter free (FFF) beams became available for application in modern radiotherapy. There are several advantages of FFF beams over conventional flattening filtered (cFF) beams, however differences in beam spectra at the point of interest in a phantom potentially affect the ion chamber response. Beams are also non-uniform over the length of a typical reference ion chamber and recombination is usually larger. Read More

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January 2018
2 Reads

Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study.

Lancet Gastroenterol Hepatol 2018 03 30;3(3):181-191. Epub 2018 Jan 30.

Department of Surgery, Leiden University Medical Center, Leiden, Netherlands. Electronic address:

Background: Tumour-targeted fluorescence imaging has the potential to advance current practice of oncological surgery by selectively highlighting malignant tissue during surgery. Carcinoembryonic antigen (CEA) is overexpressed in 90% of colorectal cancers and is a promising target for colorectal cancer imaging. We aimed to assess the tolerability of SGM-101, a fluorescent anti-CEA monoclonal antibody, and to investigate the feasibility to detect colorectal cancer with intraoperative fluorescence imaging. Read More

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March 2018
24 Reads

Para-aortic lymphadenectomy in advanced stage cervical cancer, a protocol for comparing safety, feasibility and diagnostic accuracy of surgical staging versus PET-CT; PALDISC trial.

Pilot Feasibility Stud 2018 4;4:27. Epub 2018 Jan 4.

Department of Gynaecology, Radboud University Medical Centre, Radboudumc Institute for Health Sciences, P.O. Box 9101, 6500 HB Nijmegen, the Netherlands.

Background: Currently, a PET-CT is used to assess the need for extended field radiotherapy of para-aortic lymph nodes (PALN) in International Federation of Gynaecology and Obstetrics (FIGO) stage IB2, IIA2-IVA (locally advanced stage) cervical cancer. A small study established a sensitivity and specificity estimate for PALN metastases of 50% (95% CI; 7-93%) and 83% (95% CI; 52-98%), respectively. Surgical staging of PALN may lead to a higher diagnostic accuracy. Read More

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January 2018
6 Reads

Quantifying Hospital-Acquired Carriage of Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae Among Patients in Dutch Hospitals.

Infect Control Hosp Epidemiol 2018 01 7;39(1):32-39. Epub 2017 Dec 7.

3Julius Center for Health Sciences and Primary Care,University Medical Center Utrecht,Utrecht,the Netherlands.

BACKGROUND Extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) are emerging worldwide. Contact precautions are recommended for known ESBL-E carriers to control the spread of ESBL-E within hospitals. OBJECTIVE This study quantified the acquisition of ESBL-E rectal carriage among patients in Dutch hospitals, given the application of contact precautions. Read More

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January 2018
2 Reads

Online Self-Management Support for Family Caregivers to Help Them Manage Behavior Changes in Their Relative With Dementia: Study Protocol for a Randomized Controlled Trial and a Process Evaluation.

JMIR Res Protoc 2017 Nov 28;6(11):e239. Epub 2017 Nov 28.

Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands.

Background: Online interventions are potentially effective ways to support family caregivers in the management of behavior changes in their relative with dementia.

Objective: The objective of this paper is to present the design of a study evaluating and comparing 3 intervention arms for online self-management support.

Methods: A randomized controlled trial (RCT) will be conducted with a total of 81 family caregivers of community-dwelling people with dementia in the Netherlands. Read More

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November 2017
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Needs and preferences of patients with head and neck cancer in integrated care.

Clin Otolaryngol 2018 04 11;43(2):553-561. Epub 2017 Dec 11.

Scientific Center for Quality of Healthcare, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, the Netherlands.

Objectives: Incorporation of patients' perspectives in daily practice is necessary to adapt care to users' needs. However, information on patients' needs and preferences for integrated care is lacking. The aim was to explore these needs and preferences, taking patients with head and neck cancer (HNC) as example, to adapt current integrated care to be more patient-centred. Read More

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April 2018
4 Reads

[Research in the GP's practice is good for the health of all].

Ned Tijdschr Geneeskd 2017 ;161:D1996

Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap, Utrecht.

The Health Council of the Netherlands has issued a report on the importance of extramural medical research. More attention is needed for diseases with high prevalence or a high disease burden, and results from intramural research cannot always be extrapolated to the primary care setting. Scientific research is crucial for developing and evaluating primary health care, so all general practitioners (GPs) should at least open their practices to data collection for scientific research purposes. Read More

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TAS-102 and the quest for predictive biomarkers.

ESMO Open 2017 21;2(4):e000263. Epub 2017 Sep 21.

Department of Clinical Pharmacology, Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis, Amsterdam, Noord-Holland, Netherlands.

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September 2017
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EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis.

Allergy 2018 Apr 30;73(4):765-798. Epub 2017 Oct 30.

Department of Women and Child Health, Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, University of Padua, Padua, Italy.

Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Read More

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April 2018
26 Reads