302 results match your criteria Necrotizing Sialometaplasia


Necrotizing sialometaplasia: A diagnostic challenge.

Oral Oncol 2021 Jul 20;118:105349. Epub 2021 May 20.

Department of Clinical and Preventive Dentistry, Universidade Federal de Pernambuco (UFPE), Recife, Pernambuco, Brazil; Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address:

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Non-ulcerated necrotizing sialometaplasia may mimic a salivary gland tumor.

Autops Case Rep 2021 Apr 15;11:e2021244. Epub 2021 Apr 15.

Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba, Departamento de Diagnóstico Oral, Piracicaba, SP, Brasil.

Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. Read More

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Necrotizing sialometaplasia-A self-limiting condition which poses a diagnostic dilemma.

Clin Case Rep 2021 Apr 18;9(4):2019-2022. Epub 2021 Feb 18.

Department of Oral Medicine and Radiology GDCRI Bangalore India.

Necrotizing sialometaplasia can make anyone very anxious about the lesion especially if they have habit of tobacco consumption. It requires a prompt diagnosis, counseling with assurance to patient and treatment. Read More

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Necrotizing sialometaplasia of the tonsillar pillar. An unusual case.

J Clin Exp Dent 2021 Feb 1;13(2):e211-e214. Epub 2021 Feb 1.

Full time Professor of Department of Oral Pathology and Oral Medicine, Graduate and Research Division, Dental School, National Autonomous University of Mexico. Mexico city, Mexico.

Necrotizing Sialometaplasia (NS) is a rare, benign, self-limited, inflammatory and necrotizing reaction of the salivary glandular tissue. Due to the clinical picture (a painful ulcer with well-defined edges), and histopathological characteristics (nuclear and cellular pleomorphism of ductal cells) NS can mimic a malignant lesion. The correct diagnosis is important because NS shows a spontaneous resolution and therefore no further treatment is needed. Read More

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February 2021

Necrotizing sialometaplasia: a case report of a non-ulcerated histopathological presentation.

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Department of Propaedeutic and Integrated Clinic, Universidade Federal da Bahia, Salvador, Bahia.

A 27-year-old woman presented with the chief complaint of severe pain in the palate region, which had been present for two months. Upon examination, she was found to have a firm, non-ulcerated nodule measuring about 2.5cm at the palatal junction. Read More

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December 2020

[Immunohistochemical diagnosis of necrotizing sialometaplasia].

Stomatologiia (Mosk) 2020 ;99(5):92-95

National Medical Research Center of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The article presents a clinical case of an immunohistochemical study of a rare disease: necrotizing sialometaplasia in the hard palate. Due to the complexity of the differential diagnosis between necrotizing sialometaplasia and squamous cell carcinoma, an immunohistochemical method was used with antibodies to proteins Ki-67, P53, P63 and cytokeratins-7 and Immunohistochemical study established low proliferative activity of glandular cells in excretory ducts and metaplastic squamous epithelium for Ki-67 protein, significant expression of protein P63 was detected both in the ductal epithelium nuclei and in metaplastic areas and expression of the mutant protein P53 was approximately absent. Marked expression of cytokeratin-7 in the ducts cells and weak expression in necrotic acini of the glands and metaplastic epithelium was noted. Read More

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October 2020

Necrotizing sialometaplasia - Case report.

J Dent Sci 2020 Sep 25;15(3):390-392. Epub 2020 Mar 25.

Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

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September 2020

Low-Level Laser Therapy Approach of Bilateral Necrotizing Sialometaplasia of the Hard and Soft Palates.

J Lasers Med Sci 2020 21;11(3):348-354. Epub 2020 Jun 21.

DDS, MSc, PhD, Superior School of Health Science, Amazonas State University, Av. Carvalho Leal, 1777, Cachoeirinha, Manaus-AM, 69065-001, Brazil.

Necrotizing sialometaplasia (NS) is a rare locally destructive inflammatory benign disease that commonly affects the minor salivary glands. It is frequently associated with the glands located in the posterior portion of the hard and soft palates. Low-level laser therapy (LLLT), also called photobiomodulation therapy (PBMT), has been deemed a substantial method for the regenerative wound process. Read More

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A retrospective study of salivary gland diseases in 179 dogs (2010-2018).

J Vet Diagn Invest 2020 Jul;32(4):604-610

Department of Pathology (Lieske, Rissi) and Athens Veterinary Diagnostic Laboratory (Rissi), College of Veterinary Medicine, University of Georgia, Athens, GA.

Salivary gland diseases are well characterized in human medicine but are uncommonly reported in dogs. Herein we describe the clinical and pathologic features of 179 canine salivary gland biopsy submissions to the Athens Veterinary Diagnostic Laboratory from 2010 to 2018. The mean age of affected dogs was 8. Read More

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Necrotizing sialometaplasia: a malignant masquerade but questionable precancerous lesion, report of four cases.

BMC Oral Health 2020 07 14;20(1):206. Epub 2020 Jul 14.

Department of pathology, Seoul National University Boramae Hospital, 20 Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea.

Background: Necrotizing sialometaplasia (NSM) is an extremely rare benign lesion with an uncertain pathogenesis. The differential diagnosis of this lesion is challenging due to little familiarity with this entity and histologic similarity with carcinomas, especially mucoepidermoid carcinoma (MEC). The purpose of this study is to raise awareness about NSM, which is often overlooked or misdiagnosed as malignancy in a small biopsy. Read More

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Necrotizing Sialometaplasia and Bulimia: A Case Report.

Medicina (Kaunas) 2020 Apr 19;56(4). Epub 2020 Apr 19.

Egas Moniz University Institute, 2829-511 Caparica, Portugal.

Bulimia is an eating disorder with a great prevalence in young women. Due to its multifactor ethiology, bulimia has systemic consequences. In the literature, necrotising sialometaplasia is seldom associated with bulimia. Read More

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Necrotizing sialometaplasia of the palate in a young bodybuilder with anabolic androgenic steroids abuse.

Quintessence Int 2020 ;51(6):496-501

Necrotizing sialometaplasia is a benign, self-limiting, inflammatory disease of salivary glands, mainly involving the minor salivary glands in the palate. This lesion can mimic a malignant neoplasm, both clinically and histopathologically, manifesting as a submucosal swelling or as an ulcer of the palate. This report presents a case of an otherwise healthy bodybuilder with anabolic androgenic steroids abuse with bilateral necrotizing sialometaplasia in the palate, and discusses computed tomography findings in the pre-ulceration phase. Read More

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Soft Palate Subacute Necrotising Sialadenitis: A Case Report.

Indian J Otolaryngol Head Neck Surg 2019 Oct 5;71(Suppl 1):230-232. Epub 2019 Jan 5.

Department of ORL-HNS, Command Hospital (Southern Command), AFMC, Wanowari, Pune, 411040 India.

Subacute Necrotising Sialadenitis (SANS) is a self-limiting, inflammatory disorder of minor salivary glands of unknown etiology. Minor salivary glands over soft and hard palate are most commonly affected. SANS shares considerable clinical features with necrotizing sialometaplasia, which is also the commonest differential diagnosis. Read More

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October 2019

A case of necrotizing sialometaplasia.

Acta Otorrinolaringol Esp (Engl Ed) 2020 Sep - Oct;71(5):328-329. Epub 2019 Sep 30.

Servicio de Radiodiagnóstico, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.

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September 2019

Necrotizing Sialometaplasia of the Hypopharynx.

Ear Nose Throat J 2019 Oct-Nov;98(9):NP138-NP141. Epub 2019 Apr 9.

Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA.

Necrotizing sialometaplasia (NSM) is a benign, reactive metaplastic condition of the minor salivary gland tissue typically seen in the setting of injury, chemical or traumatic, and is nonneoplastic and self-limited. The diagnosis may be challenging as it may clinically mimic malignancy. We present the case of a 74-year-old male with a 1 pack per day smoking history for 60 years who presented with a reported 20-pound weight loss, dysphagia, and dysphonia progressing over the course of 6 months and found to have a 3. Read More

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Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.

Oral Dis 2019 May 5;25(4):1084-1090. Epub 2019 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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Infarcted Warthin tumor with mucoepidermoid carcinoma-like metaplasia: a case report and review of the literature.

J Med Case Rep 2019 Jan 14;13(1):12. Epub 2019 Jan 14.

Kosai's Clinic for Otorhinolaryngology, 2-169-1, Hitotsubashi-town, Kochi-city, Kochi, 780-0981, Japan.

Background: Warthin tumor is a common, benign, painless salivary gland neoplasm. Rarely, Warthin tumors show large areas of squamous metaplasia; such Warthin tumors are called metaplastic or infarcted Warthin tumors because they are occasionally accompanied with tumor necrosis. The histological distinction between mucoepidermoid carcinomas and the metaplastic portions of Warthin tumors can be challenging; without a genetic study, mucoepidermoid carcinomas can be misdiagnosed as metaplastic Warthin tumors. Read More

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January 2019

Necrotising sialometaplasia: a diagnostic perplexity? An innocent entity to malignant masquerade.

J Exp Ther Oncol 2018 May;12(3):185-188

Department of Conservative Dentistry & Endodontics, Teerthanker Mahaveer Dental College and Research Centre, Teerthanker Mahaveer University, India.

Objective: Necrotising Sialometaplasia is a benign self limiting reactive condition of major and minor salivary glands, which can arouse suspicion for malignancy, clinically and histopathologically. Here, we report a case of 38-year-old female with a painful ulcer on the palate. The case enlightens the importance of clinicopathologic correlation and diligent follow up in diagnosis and management of the case. Read More

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Imaging of Minor Salivary Glands.

Neuroimaging Clin N Am 2018 May;28(2):295-302

Department of Radiology, Michigan State University, Michigan State University Health Team, 846 Service Road, East Lansing, MI 48824, USA.

Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. Read More

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Unusual Presentation of Castleman Disease in the Oral Cavity.

J Craniofac Surg 2017 May;28(3):e218-e219

*Eduardo Anitua Clinic †Eduardo Anitua Foundation, Vitoria, Spain.

Castleman disease (CD) is a benign lymphoproliferative disease of unknown aetiology that rarely occurs in the head and neck region. Herein, the authors describe a patient of intraoral CD and its management. A 55-year-old female patient attended our clinic because of a 1-year history of a mass in the posterior hard palate region. Read More

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Man With Painless Oral Lesions.

Ann Emerg Med 2017 May;69(5):e59-e60

Department of Emergency Medicine, Staten Island University Hospital, Northwell Health, Staten Island, NY.

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Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis.

J Stomatol Oral Maxillofac Surg 2017 Feb 3;118(1):63-65. Epub 2017 Feb 3.

Service de stomatologie et chirurgie maxillofaciale, DHU FAST, groupe hospitalier Pitié-Salpêtrière Charles-Foix, AP-HP, 75013 Paris, France.

Introduction: Necrotizing sialometaplasia is a benign inflammatory lesion involving most frequently the minor salivary gland of the hard palate. Involvement of the parotid gland is rare, involvement of the parotid gland associated with facial palsy is exceptional.

Case Report: A 56-year-old male patient with Marfan syndrome presented with swelling and inflammation of the left parotid gland associated with progressively complete facial nerve paralysis. Read More

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February 2017

Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug.

Case Rep Dent 2016 19;2016:9545861. Epub 2016 Oct 19.

Unit of Oral and Maxillofacial Surgery, Maggiore della Carità University Hospital, Novara, Italy.

Necrotizing sialometaplasia is a rare, benign, self-limiting, necrotizing process involving the minor salivary glands, mainly the mucoserous glands of the hard palate. It is thought to be the result of an ischemic event of the vasculature supplying the salivary gland lobules. Some predisposing factors such as smoking, use of alcohol, denture wearing, recent surgery, traumatic injuries, respiratory infections, systemic diseases bulimia, and anorexia have been described. Read More

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October 2016

Bilateral necrotising sialometaplasia.

BMJ Case Rep 2016 Oct 27;2016. Epub 2016 Oct 27.

Department of Oral Pathology, Pacific Dental College & Hospital, Udaipur, Rajasthan, India.

Necrotising sialometaplasia is a benign, necrotising, self-healing inflammatory condition categorised as idiopathic disease of salivary glands. This condition holds diagnostic importance because of its clinical and histopathological presentation, which is ambiguous, and can be misdiagnosed as carcinoma particularly squamous cell carcinoma or mucoepidermoid carcinoma. This report describes a case of bilateral necrotising sialometaplasia occurring in a 38-year-old male patient. Read More

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October 2016

Morphological and Histological Effects of Radiofrequency and Laser (KTP and Nd:YAG) Treatment of the Inferior Turbinates in Animals.

Surg Innov 2017 Feb 13;24(1):5-14. Epub 2016 Oct 13.

1 University of Pécs, Pécs, Hungary.

The aim of this study was to evaluate the short and medium-term effects of radiofrequency (RF) and potassium titanyl phosphate (KTP) and neodymium-yttrium-aluminum garnet (Nd:YAG) laser treatment on the inferior turbinate mucosa in a porcine model. Following randomization, the inferior turbinates were treated either with RF submucosally or with the KTP or the Nd:YAG laser on the surface under videoendoscopic control. Tissue samples were taken at the end of postoperative weeks 1 and 6, and were evaluated macroscopically and histopathologically. Read More

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February 2017

Necrotising sialometaplasia at multiple sites: a therapeutic challenge to oral physicians.

BMJ Case Rep 2016 Aug 31;2016. Epub 2016 Aug 31.

Department of Oral Medicine and Radiology, Saveetha Dental College, Saveetha University, Chennai, Tamil Nadu, India.

Necrotising sialometaplasia is a rare, benign and self-limiting inflammatory lesion that commonly involves minor salivary glands. Its clinical appearance, signs and symptoms very often mimic a carcinomatous lesion, thus creating a diagnostic dilemma for the clinician. Necrotising sialometaplasia being an important differential for an apparent carcinoma should be excluded histologically prior to radical therapy. Read More

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Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis.

Indian J Pathol Microbiol 2016 Apr-Jun;59(2):232-234

Department of Pathology and Lab Medicine, All Institute of Medical Sciences, New Delhi, India.

Necrotizing sialometaplasia is a rare benign and self-limiting disease, which commonly affects the minor salivary glands. Typically, it involves the seromucinous glands located at palate, buccal mucosa, tongue, tonsil, nasal cavity, trachea, larynx, maxillary sinus, and retromolar trigone. We report two such cases of necrotizing sialometaplasia to create awareness among the pathologists and surgeons because of its close morphological and clinical resemblance to squamous cell carcinoma. Read More

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Histological reclassification of parotid gland carcinomas: importance for clinicians.

Eur Arch Otorhinolaryngol 2016 Nov 21;273(11):3937-3942. Epub 2016 Apr 21.

Department of Otolaryngology, Medical University of Gdańsk, Gdańsk, Poland.

Reassessment of histological specimens of salivary gland carcinomas is associated with a change of primary diagnosis in a significant number of patients. The authors evaluated the relation between reclassification/verification of histological diagnosis and the clinical course of parotid gland carcinomas. Histological and immunohistochemical examinations of 111 specimens of parotid gland carcinomas operated on during the years 1992-2010 were revised and in some cases supplemented with cytogenetic tests (FISH), to verify the diagnosis and potentially reclassify the tumours. Read More

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November 2016

[Aphthous ulcers and oral ulcerations].

Presse Med 2016 Feb 12;45(2):215-26. Epub 2016 Feb 12.

CHRU de Tours, université François-Rabelais de Tours, hôpital Trousseau, Inra, service de dermatologie, 37044 Tours cedex 01, France.

Aphthous ulcers are painful ulcerations located on the mucous membrane, generally in the mouth, less often in the genital area. Three clinical forms of aphthous ulcers have been described: minor aphthous ulcers, herpetiform aphthous ulcers and major aphthous ulcers. Many other conditions presenting with oral bullous or vesiculous lesions orulcerations and erosions can be mistaken for aphthous ulcers. Read More

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February 2016