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    1 OF 88

    Necrotizing infection of the heart.
    Clin Imaging 2018 Feb 6;51:111-113. Epub 2018 Feb 6.
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States.
    A case of necrotizing infection of the heart is presented. A 70-year-old woman presented with vague chest and abdominal pain. CT of the abdomen and pelvis was initially obtained, which demonstrated gas in the myocardium of the left ventricle. Read More

    Scrotal reconstruction with superomedial fasciocutaneous thigh flap.
    Rev Col Bras Cir 2018 15;45(1):e1389. Epub 2018 Feb 15.
    Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
    Objective: to describe the use of a superomedial fasciocutaneous thigh flap for scrotal reconstruction in open areas secondary to the surgical treatment of perineal necrotizing fasciitis (Fournier's gangrene).

    Methods: retrospective analysis of cases treated at the Plastic Surgery Service of Santa Casa de Misericórdia, São Paulo, from 2009 to 2015.

    Results: fifteen patients underwent scrotal reconstruction using the proposed flap. Read More

    Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review.
    Pediatr Infect Dis J 2018 Feb 7. Epub 2018 Feb 7.
    Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
    Background: There is no consensus regarding approaches to infantile group B streptococcal (GBS) head and neck cellulitis and necrotizing fasciitis. We present a case of GBS necrotizing cellulitis and summarizes the literature regarding the presentation and management of infantile head and neck GBS cellulitis and necrotizing fasciitis.

    Methods: The literature was searched using PubMed, Web of Science, EMBASE, and Medline (inception to April 2017) by two independent review authors. Read More

    Coverage of the scrotum after Fournier's gangrene.
    GMS Interdiscip Plast Reconstr Surg DGPW 2018 15;7:Doc01. Epub 2018 Jan 15.
    Plastic Surgery Center, Faculty of Medicine, Mansoura University, Egypt.
    Fournier's gangrene is a necrotizing fasciitis caused by mixed aerobic and anaerobic bacteria and results in loss of skin and subcutaneous tissue in the perineal area. Coverage of testis varies from closure of the defect primarily, burying inside the thigh, using the remnants of the scrotum for tissue expansion and coverage by flaps. In this manuscript, scrotal advancement flaps and pudendal thigh flaps were used for coverage of the testis unilaterally or bilaterally according to the size of the defect following Fournier gangrene. Read More

    Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.
    Front Cell Infect Microbiol 2018 24;8:10. Epub 2018 Jan 24.
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan.
    is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. Read More

    Sacral Pressure Ulcer-induced Fournier's Gangrene Extending to the Retroperitoneum: A Case Report.
    Wounds 2018 Jan;30(1):E5-E8
    National Hospital Organization Nagasaki Medical Center, Ohmura City, Japan.
    Introduction: Fournier's gangrene (FG) is a type of necrotizing fasciitis of the perineum and scrotum that is characterized by very rapid progression. Sacral pressure ulcers are one of the causes of FG.

    Case Report: An 85-year-old man was referred to the National Hospital Organization Nagasaki Medical Center (Ohmura City, Japan) with a diagnosis of FG extending to the retroperitoneum caused by a sacral pressure ulcer. Read More

    Cellulitis and Soft Tissue Infections.
    Ann Intern Med 2018 Feb;168(3):ITC17-ITC32
    University of California, San Francisco, California (R.B., H.C.).
    Cellulitis and soft tissue infections are a diverse group of diseases that range from uncomplicated cellulitis to necrotizing fasciitis. Management of predisposing conditions is the primary means of prevention. Cellulitis is a clinical diagnosis and thus is made on the basis of history and physical examination. Read More

    Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report.
    Medicine (Baltimore) 2018 Feb;97(5):e9794
    Division of Rheumatology/Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital.
    Rationale: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. Read More

    Should we consider IgG hypogammaglobulinemia a risk factor for severe complications of Ludwig angina?: A case report and review of the literature.
    Medicine (Baltimore) 2017 11;96(47):e8708
    Intensive Care Unit.
    Rationale: Cervical necrotizing fasciitis (CNF) and descending necrotizing mediastinitis (DNM) are rare forms of complication of Ludwig angina. These potentially lethal infections are difficult to recognize in early stages and are often associated with predisposing factors like diabetes and immunocompromised states. Moreover, IgG hypogammaglobulinemia (hypo-IgG) is considered to be a risk factor of mortality in patients with septic shock; however, it is not routinely quantified in patients with extremely serious infections, particularly in cases with no history or evidence of immunocompromising disorders. Read More

    Pathogenic mechanisms of invasive group A Streptococcus (GAS) infections by influenza virus-GAS superinfection.
    Microbiol Immunol 2018 Jan 27. Epub 2018 Jan 27.
    Department of Laboratory Sciences, Faculty of Health Sciences, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan.
    Group A Streptococcus (GAS) are pathogenic bacteria of the genus Streptococcus, and cause severe invasive GAS infections that comprise a wide range of diverse diseases, including acute respiratory distress syndrome, renal failure, toxic shock-like syndrome (TSLS), sepsis, cellulitis, and necrotizing fasciitis. The essential virulence, infected host, and external environmental factors required for invasive GAS infections still have not known. We demonstrated that superinfection with influenza virus and GAS induced invasive GAS infections in a mouse model, and then several investigators reported clinical cases of invasive GAS infections secondary to influenza virus infection in Japan, the United States, Canada, the United Kingdom, China, and others. Read More

    Fournier's Gangrene: Clinical Presentation of 13 Cases.
    Med Sci Monit 2018 Jan 28;24:548-555. Epub 2018 Jan 28.
    Department of General, Oncological and Functional Urology, Medical University of Warsaw, Warsaw, Poland.
    BACKGROUND Fournier's gangrene (FG) is a fulminant form of infective, polymicrobial, necrotizing fasciitis of the perineal, genital, and perianal regions. It commonly affects men, but women and children may also develop this type of tissue necrosis. MATERIAL AND METHODS This study is a retrospective analysis of the management of 13 cases of Fournier's gangrene, diagnosed from among about 45 000 patients (men, women, and children) treated in the Department of General, Oncological, and Functional Urology (Medical University of Warsaw) from 1995 to 2013. Read More

    Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beads.
    PLoS One 2018 25;13(1):e0191676. Epub 2018 Jan 25.
    CytoSorbents Corporation, Monmouth Junction, New Jersey, United States of America.
    Objective: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In sepsis and septic shock, pathogen-associated molecular pattern molecules (PAMPS), such as bacterial exotoxins, cause direct cellular damage and/or trigger an immune response in the host often leading to excessive cytokine production, a maladaptive systemic inflammatory response syndrome response (SIRS), and tissue damage that releases DAMPs, such as activated complement and HMGB-1, into the bloodstream causing further organ injury. Cytokine reduction using extracorporeal blood filtration has been correlated with improvement in survival and clinical outcomes in experimental studies and clinical reports, but the ability of this technology to reduce a broader range of inflammatory mediators has not been well-described. Read More

    The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study.
    Ann Plast Surg 2018 Feb;80(2S Suppl 1):S75-S78
    Background: Little is known about the national population-based incidence rates of necrotizing fasciitis (NF) and related epidemiological profiles in Asian countries. We plastic surgeons always face and treat this complicated disease in the first line at the hospital.

    Methods: Using Taiwan's National Health Insurance inpatient claims data from 2005 through 2010, we investigated the national annual incidence rate of NF by sex, age, year, month, beneficiary category, and region. Read More

    [Severe Lower Extremity Infections Treated with Hip Disarticulation - Case Series].
    Acta Chir Orthop Traumatol Cech 2017 ;84(5):396-400
    Oddělení ortopedie, Traumatologicko-ortopedické centrum, Krajská nemocnice Liberec, a.s.
    Hip disarticulation is a major ablative procedure with serious risks as well as consequences for the patient, performed rarely for a lower extremity infection. According to literature, the mortality rate in these procedures reaches up to 60%. Unfavourable prognostic factors are emergency surgeries without adequate preparation of the patient and surgeries indicated for an ischemic terrain infection. Read More

    Group A Streptococci-Associated Necrotizing Fasciitis following Cat Bite in an Immunocompromised Patient.
    Case Rep Crit Care 2017 16;2017:3718360. Epub 2017 Nov 16.
    USD Sanford School of Medicine, Vermillion, SD, USA.
    Necrotizing soft tissue infections are characterized clinically by fulminant tissue destruction, systemic signs of toxicity, and high mortality. Accurate diagnosis and appropriate treatment must include early surgical intervention and antibiotic therapy. Mortality rate is very high and could be even higher in an immunocompromised host. Read More

    Retroperitoneal Necrotizing Fasciitis from Fournier's Gangrene in an Immunocompromised Patient.
    Case Rep Surg 2017 3;2017:5290793. Epub 2017 Dec 3.
    The Arizona Burn Center, Maricopa Integrated Health System, Phoenix, AZ, USA.
    Introduction: Necrotizing fasciitis (NF) is a devastating soft tissue disease causing fulminant clinical deterioration, and extension into the retroperitoneum has a high mortality rate. This disease process demands a strong clinical suspicion for early identification which must be coupled with frequent wide surgical debridements and intravenous antibiotics for improved outcomes. Various clinical risk factors may render a weakness in the patient's immune status including diabetes mellitus, chronic renal failure, obesity, and autoimmune disorders, such as a human immunodeficiency virus (HIV) infection. Read More

    [Necrotizing fasciitis of the hand and forearm : Acute surgical treatment and defect reconstruction with MatriDerm® and split-thickness skin graft].
    Unfallchirurg 2018 Jan 10. Epub 2018 Jan 10.
    Landeskrankenhaus Villach, Nikolaigasse 43, 9500, Villach, Österreich.
    This case report describes a 55-year-old male patient with type II necrotizing fasciitis (NF) of the hand and forearm. The rapid progression of the tissue infection could be successfully stopped with radical surgical débridement and antibiotic therapy. For the reconstruction of the extensive loss of soft tissue a combination of split-thickness skin graft (STSG) and the synthetic dermal substitute MatriDerm® was used. Read More

    Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases.
    Ann Ital Chir 2017 Dec 18;6. Epub 2017 Dec 18.
    Necrotizing fasciitis is one of the most dangerous complication of an abscess and it is still a disease with a high mortality. In this work, we decided to consider two cases: the first one concerns a male subject, aged 66, deceased because of a fatal necrotizing fasciitis associated to a cervical descending mediastinitis, which evolved from a primary peritonsillar abscess; the second is about a 50-year-old woman with a perineal abscess, then evolved into necrotizing fasciitis associated to a fatal septis shock. After a systematic consideration of necrotizing fasciitis as pathology and an analysis of the possible related risks to a diagnostic or therapeutic delay, we analyzed the particular history of both cases to underline the possible critical issues in professional behavior of the medical staff intervened. Read More

    Successful management of a 24-year-old pregnant woman with necrotising fasciitis of the forearm.
    BMJ Case Rep 2018 Jan 6;2018. Epub 2018 Jan 6.
    Department of Trauma and Orthopaedics, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK.
    A 24-year-old woman who was 24 weeks pregnant presented to the emergency department with septic shock and an elbow wound that had become infected. She sustained an injury to the tip of the right elbow on a light switch 4 days prior. In the space of 1 day, she developed a necrotising soft tissue infection, which was rapidly spread to the forearm with florid sepsis. Read More

    Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.
    Infect Chemother 2017 Dec;49(4):301-325
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
    Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

    Rapid identification of pathogens responsible for necrotizing fasciitis on an integrated microfluidic system.
    Biomicrofluidics 2017 Nov 12;11(6):064108. Epub 2017 Dec 12.
    Department of Orthopaedic Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 61363, Taiwan.
    Necrotic fasciitis (NF) is a particularly aggressive and serious infection of the fascia that can penetrate into the musculature and internal organs, resulting in death if not treated promptly. In this work, an integrated microfluidic system composed of micropumps, microvalves, and micromixers was used to automate the detection of pathogens associated with NF. The entire molecular diagnostic process, including bacteria isolation, lysis, nucleic acid amplification and optical detection steps, was enacted on this developed system. Read More

    Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province.
    BMC Infect Dis 2017 12 28;17(1):792. Epub 2017 Dec 28.
    Burns and Plastic Reconstruction Unit, the First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, China.
    Background: To investigate the clinical characteristics and treatment outcomes in necrotizing fasciitis (NF) patients in a reconstructive unit in northeastern China.

    Methods: Medical records of patients diagnosed with and treated for NF in the extremities from November 2013 to December 2016 were retrospectively reviewed. Demographic data, clinical presentation, duration of signs and symptoms, location of infection, predisposing factors, causative microbiological organisms, laboratory risk indicator for necrotizing fasciitis (LRINEC) score, number of surgical debridements, length of hospital stay, treatments, and outcomes were recorded. Read More

    Treatment of severe skin and soft tissue infections: a review.
    Curr Opin Infect Dis 2017 Dec 22. Epub 2017 Dec 22.
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
    Purpose Of Review: To review the salient features of the management of severe skin and soft tissue infections (SSTIs), including toxic shock syndrome, myonecrosis/gas gangrene, and necrotizing fasciitis.

    Recent Findings: For severe SSTIs, intensive care, source control, and broad-spectrum antimicrobials are required for the initial phase of illness. There is an increasing focus on the utility of rapid diagnostic tests to help in selection and de-escalation of antimicrobials for SSTIs. Read More

    Contemporary non-surgical approach for faecal diversion in a case of Fournier's gangrene.
    BMJ Case Rep 2017 Dec 22;2017. Epub 2017 Dec 22.
    Department of General Surgery, Seth GS Medical College and KEM Hospital, Mumbai, India.
    Fournier's gangrene is a fatal necrotising fasciitis of the perineum, genitals and lower abdomen. Patients often need an aggressive surgical debridement, and in few cases, a diverting colostomy. We report the case of a 70-year-old man with multiple comorbidities diagnosed with Fournier's gangrene, who underwent debridement and had a wound complication due to faecal contamination. Read More

    A surgeon's nightmare: pyoderma gangrenosum with pathergy effect mimicking necrotising fasciitis.
    BMJ Case Rep 2017 Dec 20;2017. Epub 2017 Dec 20.
    Department of Orthopaedics and Traumatology, North District Hospital, Hong Kong, China.
    A 53-year-old woman was admitted for vulval swelling and fever. She was initially diagnosed with vulval cellulitis and given parenteral antibiotics. Within 1 week, she developed necrotic-looking skin lesions extending from her vulva to her buttock. Read More

    Gangrenous Necrotizing Cutaneous Mucormycosis in an Immunocompetent Neonate: A Case Report from Oman.
    J Trop Pediatr 2017 Dec 15. Epub 2017 Dec 15.
    Department of Pediatrics, Nizwa Hospital, Nizwa 611, Sultanate of Oman.
    We describe a case of progressive cutaneous mucormycosis, which caused gangrenous necrotizing fasciitis, in an immunocompetent neonate from Oman. Extensive wound contamination and a favorable environment for the growth of Mucorales were the predisposing factors. Early aggressive management including frequent wound debridement, targeted pharmacotherapy with liposomal amphotericin B and supportive care is pivotal for improved outcomes. Read More

    Severe Fournier's gangrene-a conjoint challenge of gynaecology and plastic surgery.
    J Surg Case Rep 2017 Dec 8;2017(12):rjx239. Epub 2017 Dec 8.
    Department of Hand, Plastic and Reconstructive Surgery-Burn Center-BG Trauma Center Ludwigshafen, Ludwigshafen, Germany.
    Necrotizing fasciitis (NF) is a rare soft tissue infection characterized by rapidly progressing necroses and a high mortality. Prompt diagnosis and immediate medical treatment including radical debridement and broad spectrum antibiotics are the key to successful management. We report on a 46-year-old diabetic female who developed extensive, deep necroses in the perineal area and proximal thighs within a few days. Read More

    Quantifying the Effect of Diabetes on Surgical Hand and Forearm Infections.
    J Hand Surg Am 2018 Feb 12;43(2):105-114. Epub 2017 Dec 12.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, St Louis, MO. Electronic address:
    Purpose: Diabetes has long been established as a risk factor for hand and forearm infections. The purpose of this study was to review the effect of glycemic factors on outcomes among diabetic patients with surgical upper-extremity infections. We hypothesized that diabetic inpatients may benefit from stronger peri-infection glycemic control. Read More

    Wound healing of cutaneous substance losses based on infectious, inflammatory and traumatic skin disorders: The experience of a center.
    Ann Chir Plast Esthet 2017 Nov 24. Epub 2017 Nov 24.
    Département de chirurgie plastique et reconstructrice, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France.
    Introduction: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon.

    Materials And Methods: This was a retrospective study. Read More

    Modern management of diabetic foot osteomyelitis. The when, how and why of conservative approaches.
    Expert Rev Anti Infect Ther 2018 Jan 19;16(1):35-50. Epub 2017 Dec 19.
    b Department of Medicine , University of Washington School of Medicine , Seattle , WA , USA.
    Introduction: Diabetic foot osteomyelitis (DFO) has long been considered a complex infection that is both difficult to diagnose and treat, and is associated with a high rate of relapse and limb loss. Areas covered: DFO can usually be diagnosed by a combination of clinical evaluation, serum inflammatory markers and plain X-ray. When the results of these procedures are negative or contradictory, advanced imaging tests or bone biopsy may be necessary. Read More

    Nursing management of childhood chickenpox infection.
    Emerg Nurse 2017 Dec;25(8):32-41
    Torbay Hospital, Torquay, England.
    Chickenpox is an extremely contagious infectious disease caused by varicella zoster virus (VZV). It is a common childhood illness characterised by an itchy vesicular rash and fever, which usually resolves spontaneously without medical intervention. Serious, and rarely fatal, complications can occur, including pneumonia, central nervous system infection, overwhelming secondary bacterial infections, especially with Group A streptococcus, and necrotising fasciitis. Read More

    Open-to-Air Is a Viable Option for Initial Wound Care in Necrotizing Soft Tissue Infection that Allows Early Detection of Recurrence without Need for Painful Dressing Changes or Return to Operating Room.
    Surg Infect (Larchmt) 2018 Jan 6;19(1):65-70. Epub 2017 Dec 6.
    1 Department of Surgery, Texas Tech University Health Sciences Center , School of Medicine, Lubbock, Texas.
    Background: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. Read More

    [Amputation of an arm due to infection with Vibrio vulnificus after beach holiday].
    Ugeskr Laeger 2017 Nov;179(48)
    Infection with Vibrio vulnificus is a rare condition with approximately 11 cases reported in the Danish literature. It is characterized by soft tissue infection/wound, necrotizing fasciitis and septicaemia. In this case report we present a patient admitted with a rapid progression and sepsis consistent with V. Read More

    Necrotizing fasciitis associated with primary cutaneous B-cell lymphoma. A case report.
    G Chir 2017 May-Jun;38(3):130-134
    Necrotizing fasciitis is a rapidly progressive and life-threatening infection of the deeper skin layers and subcutaneous tissues that moves along the facial planes.

    Objectives: We present the rare case of a patient with necrotizing fasciitis associated with high malignancy b-cell lymphoma. Our purpose is to investigate the probable connection between the two pathologies and evaluate the importance of early surgical intervention. Read More

    Complete penile skin necrosis.
    Turk J Urol 2017 Dec 1;43(4):556-559. Epub 2017 Dec 1.
    Department of Urology, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.
    Superficial penile skin infections may be presented in different clinical situations that vary from simple infection to organ loss and serious morbidity and mortality. Antibiotic treatment and, if necessary, urgent debridement is required. A 46-year-old male patient with the complaints of urethral discharge and pain admitted to our outpatient clinic. Read More

    Orofacial Bacterial Infectious Diseases: An Update.
    J Int Soc Prev Community Dent 2017 Oct 30;7(Suppl 2):S61-S67. Epub 2017 Oct 30.
    Department of Oral Pathology, Dental Research Center, Research Centre for Molecular Medicine, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.
    Objectives: Most of the oral infections with odontogenic origin are very common and can be treated by tooth extraction, endodontic therapy, or surgical treatment. Other infectious lesions are the manifestations of systemic diseases such as tuberculosis and syphilis. Skin and underlying subcutaneous tissue, fascia, or muscle is also involved with infectious diseases which range from superficial epidermal infections to very serious necrotizing fasciitis. Read More

    Effect of transfer status on outcomes for necrotizing soft tissue infections.
    J Surg Res 2017 Dec 1;220:372-378. Epub 2017 Sep 1.
    Department of Surgery Division of Trauma and Acute Care Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
    Background: Whether patients with necrotizing soft tissue infections (NSTI) who presented to under-resourced hospitals are best served by immediate debridement or expedited transfer is unknown. We examined whether interhospital transfer status impacts outcomes of patients requiring emergency debridement for NSTI.

    Methods And Materials: We conducted a retrospective review studying patients with an operative diagnosis of necrotizing fasciitis, Fournier's gangrene, or gas gangrene in the 2010-2015 American College of Surgeons National Surgical Quality Improvement Program Participant Use Data Files. Read More

    Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report.
    J Med Case Rep 2017 Nov 28;11(1):332. Epub 2017 Nov 28.
    Department of Surgery, University of Illinois at Chicago, Chicago, 60612, IL, USA.
    Background: Fusobacterium necrophorum is a common agent of disease in humans, but the occurrence of primary infections outside the head and neck area is extremely rare. While infection with Fusobacterium necrophorum has a rather benign course above the thorax, the organism is capable of producing very severe disease when located in unusual sites, including various forms of septic thrombophlebitis. No infections of the leg have been documented before; thus, antibiotic coverage for Fusobacterium is currently not recommended in this area. Read More

    Raoultella planticola: A Rare Cause of Wound Infection.
    Wounds 2017 Nov;29(11):E103-E105
    Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. Read More

    Necrotizing fasciitis after high-dose rate brachytherapy and external beam radiation for prostate cancer: a case report.
    BMC Urol 2017 Nov 21;17(1):107. Epub 2017 Nov 21.
    Department of Urology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
    Background: In recent years, the delayed side effects associated with radiotherapy for prostate cancer have drawn the interest of urologists. Although urosymphyseal fistula is one of these delayed side effects, this serious complication is rarely described in literature and is poorly recognized.

    Case Presentation: We report our experience in treating a 77-year-old male patient with necrotizing fasciitis after high-dose rate brachytherapy plus external beam radiation for prostate cancer. Read More

    Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.
    J Microbiol Immunol Infect 2017 Nov 13. Epub 2017 Nov 13.
    Department of Molecular Medicine & Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:
    Background: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N-terminal domain of unknown function. Read More

    Presentation and Diagnosis of Fournier Gangrene.
    Urology 2017 Nov 13. Epub 2017 Nov 13.
    Department of Urology, University of Washington School of Medicine, Seattle, WA.
    Necrotizing fasciitis is a severe type of necrotizing soft tissue infection involving the superficial fascia and subcutaneous tissues. Fournier gangrene, a type of necrotizing fasciitis, affects the genitalia or perineum. Although a rare health condition, Fournier gangrene can result in significant morbidity and unnecessary mortality following delay in diagnosis and management. Read More

    Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8720
    Department of Hand Surgery, Wuxi NO.9 People's Hospital Affiliated to Soochow University, Wuxi, China.
    Rationale: Necrotizing fasciitis (NF), characterized by widespread fascial necrosis, is a rare disease in clinic. Fournier gangrene (FG) is a special type of NF involved of perineum and scrotum. To our knowledge, no article has reported on bilateral femoral posterior neurocutaneous perforater flap treating for FG. Read More

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