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Urology 2022 May 15. Epub 2022 May 15.

University of Iowa, Carver College of Medicine, Department of Urology. Electronic address:

Objective: To evaluate the efficacy of early necrotizing soft-tissue infections of the genitalia (NSTIG) component separation, primary wound closure (CSC). We hypothesized that early CSC would be safe, decrease the need for split-thickness skin grafting (STSG) and decrease wound convalescence time.

Materials/methods: Management of consecutive NSTIG patients from a single institution were evaluated. Read More

Gan To Kagaku Ryoho 2022 May;49(5):597-599

Dept. of Medical Oncology, Tokyo Saiseikai Central Hospital.

A 52-year-old man diagnosed with Stage ⅢA rectal and anal canal cancer underwent abdominal perineal resection using Miles's method. Two years later, local recurrence and lung metastases were detected using contrasted CT imaging. First-line chemotherapy of XELOX was administered for 4 months until the disease progressed and lung metastases developed. Read More

Int J Surg Open 2022 May 11:100488. Epub 2022 May 11.

Department of Surgery, University Hospital Limerick, Ireland.

Necrotising fasciitis (NF) is a severe soft tissue infection that is associated with a high risk of morbidity and mortality. During the coronavirus disease 19 (COVID-19) pandemic, the population has been actively discouraged from presenting to emergency medical services unless absolutely necessary. While this was an important step in allowing for preservation of limited resources in a time of crisis, it may have resulted in immeasurable 'secondary victims' of the pandemic as patients with time-critical conditions delay hospital presentation. Read More

Curr Med Res Opin 2022 May 14:1-13. Epub 2022 May 14.

Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Greece.

Introduction: are gram-negative opportunistic bacteria, mainly found in aquatic environments. Hematologic patients are particularly at risk of soft tissue infections and septicemia, especially during chemotherapy-induced neutropenia.

Case Description: A 46-year-old man was diagnosed with acute lymphoblastic leukemia characterized by the rare t(12;17)(p13;q21)/ aberration. Read More

J Hand Surg Am 2022 May 7. Epub 2022 May 7.

Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, WA. Electronic address:

Purpose: Necrotizing soft tissue infection (NSTI) of the upper extremity is characterized by rapid progression, local tissue necrosis, systemic toxicity, and a high mortality rate. The negative consequences of debridement are balanced against preservation of life and limb. The primary objective of this study was to identify predictors of mortality in upper extremity NSTI. Read More

Cureus 2022 Apr 8;14(4):e23944. Epub 2022 Apr 8.

Department of Surgery, Columbia University College of Physicians and Surgeons, Harlem Hospital Center, New York, USA.

Necrotizing soft tissue infections (NSTIs) are severe, life-threatening forms of infection. Tissues from the epidermis to the deep musculature may be affected. This includes necrotizing forms of cellulitis, myositis, and fasciitis. Read More

Urol Case Rep 2022 May 1;42:102037. Epub 2022 Mar 1.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

In contemporary urological practice periurethral abscesses are rare. We report the case of a 61-year-old presenting with a painless penile mass and urinary retention. He underwent imaging with ultrasonography, targeted antibiotics and successful source control through open incision and drainage. Read More

Br J Hosp Med (Lond) 2022 Apr 6;83(4):1-8. Epub 2022 Apr 6.

Division of Emergency Medicine, Far East Rand Hospital, University of the Witwatersrand, South Africa.

Most life-threatening conditions form a coherent clinical picture, with examination findings confirming the patient's history. However, pain out of proportion to examination findings can also signify an emergency - acute compartment syndrome, bowel ischaemia, necrotising fasciitis and acute aortic dissection may all present in this way. A lack of situational awareness leads doctors to erroneously rely on examination findings to flag impending catastrophe, but in such cases misdiagnosis or delayed treatment can have dire consequences. Read More

Pol J Radiol 2022 5;87:e141-e162. Epub 2022 Mar 5.

Department of Radiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

Magnetic resonance imaging (MRI) is a powerful imaging modality in the evaluation of musculoskeletal (MSK) soft tissue, joint, and bone infections. It allows prompt diagnosis and assessment of the extent of disease, which permits timely treatment to optimize long-term clinical outcomes. MRI is highly sensitive and specific in detecting the common findings of MSK infections, such as superficial and deep soft tissue oedema, joint, bursal and tendon sheath effusions, lymphadenopathy, bone marrow oedema, erosive bone changes and periostitis, and bone and cartilage destruction and sequestration. Read More

Surg Case Rep 2022 May 3;8(1):81. Epub 2022 May 3.

Department of Thoracic Surgery, International University of Health and Welfare, 852, Hatakeda, Narita, Chiba, 286-8520, Japan.

Background: Multiple deep organ abscesses associated with Staphylococcus aureus bloodstream infection (SAB) have a high mortality rate, requiring rapid removal or drainage of infective foci with long-term appropriate antimicrobial therapy. Cases in which infective foci cannot be completely removed are challenging for their management.

Case Presentation: A 77-year-old man developed multiple deep organ abscesses associated with SAB. Read More

Med Clin North Am 2022 May 4;106(3):537-543. Epub 2022 Apr 4.

Department of Internal Medicine, The Ohio State University College of Medicine, M112 Starling Loving Hall, 310 W 10th Avenue, Columbus, OH 43210, USA. Electronic address:

This article reviews the presentation, physical examination findings, and diagnosis of selective common acute infectious diseases. In this article, we review nonpurulent skin infections, infective endocarditis, and acute cholecystitis. Read More

J Fr Ophtalmol 2022 Apr 27. Epub 2022 Apr 27.

Département de chirurgie et spécialités, université des sciences de la santé, Libreville, Gabon.

J Stomatol Oral Maxillofac Surg 2022 Apr 25. Epub 2022 Apr 25.

Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases: Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

Cureus 2022 Mar 19;14(3):e23311. Epub 2022 Mar 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Sir Takhatsinhji (T) Hospital and Government Medical College, Bhavnagar, IND.

Introduction Ludwig's angina is cellulitis of submandibular space, submental space, and sublingual space. The main causative factors include dental infections (dental caries with atypical periodontitis, pericoronitis, and dental procedures). Other predisposing conditions include poor dental hygiene, dental caries, malnutrition, diabetes mellitus, AIDS, and various other immunocompromised states. Read More

Cureus 2022 Mar 11;14(3):e23076. Epub 2022 Mar 11.

Department of Internal Medicine, Deccan College of Medical Sciences, Hyderabad, IND.

Dapsone, which is used for treating dermatological conditions, can lead to neutropenia. Especially, resistant neutropenia makes patients vulnerable to invasive infections, indicating a medical emergency. Febrile neutropenia secondary to dapsone intake should be treated promptly before the development of sepsis, which may lead to shock and death. Read More

Surg Case Rep 2022 Apr 24;8(1):74. Epub 2022 Apr 24.

Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo, Japan.

Background: Necrotizing fasciitis after pancreaticoduodenectomy (PD) has never been reported. We experienced a case of necrotizing fasciitis caused by pseudoaneurysmal hemorrhage after PD.

Case Presentation: A 72-year-old male was diagnosed with cholangiocarcinoma and underwent PD. Read More

BMC Infect Dis 2022 Apr 22;22(1):396. Epub 2022 Apr 22.

Department of Respiratory and Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, No. 136, Jingzhou Street, Xiangcheng District, Hubei, 441021, China.

Background: Diabetic foot ulcer is one of the major complications for patients with diabetes, and has become an important cause of non-traumatic amputation. Necrotizing fasciitis is a life-threatening soft-tissue infection involving the fascia and subcutaneous tissue. When diabetic foot ulcers are complicated by necrotizing fasciitis (DNF), this increases the risk for amputation and mortality, making DNF treatment more complicated, and eventually leading to amputation and mortality. Read More

J Clin Med 2022 Apr 13;11(8). Epub 2022 Apr 13.

Department of Plastic, Reconstructive and Maxillo Facial Surgery, Henri Mondor Hospital, University Paris XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000 Creteil, France.

Background: Necrotizing fasciitis (NF) is a severe, potentially life-threatening condition. The aim of this study is to identify strategies aimed at reducing complications in patients with NF of the upper limb.

Methods: We conducted a retrospective study on patients admitted to our Unit for suspected NF of the upper limb. Read More

Diagnostics (Basel) 2022 Mar 31;12(4). Epub 2022 Mar 31.

Clinical-Medical Department, Faculty of Medicine and Pharmacy, Dunărea de Jos University of Galati, 800201 Galati, Romania.

In this article, we present the case of a patient who hid the real reason for which he came to the emergency room. This patient in this case is a 61-year-old man, who presented to the emergency department for symptoms relevant to respiratory disease. However, the initial diagnosis turned out to be only the "tip of the iceberg" in the evolution and treatment of this patient. Read More

Chin J Traumatol 2022 Apr 4. Epub 2022 Apr 4.

St. Joseph's University Medical Center, Department of Orthopaedic Surgery, 703 Main Street, Paterson, NJ, 07503, USA; Seton Hall University, 400 S Orange Ave, South Orange, NJ, 07079, USA.

Subcutaneous emphysema is commonly associated with infection caused by gas-producing organisms. In this case report, we describe a rare instance of traumatic subcutaneous emphysema of the hand and forearm caused by a puncture injury to the first web space of the hand. Our objective is to increase awareness of the potential for seemingly minor trauma to cause entrapment of significant air in subcutaneous tissues, thereby decreasing the likelihood that a clinically benign-appearing patient will be started down an unnecessarily aggressive treatment pathway. Read More

Clin Case Rep 2022 Apr 18;10(4):e05747. Epub 2022 Apr 18.

Surgery Department Kamenge Teaching Hospital University of Burundi Bujumbura Burundi.

Fournier's gangrene, a rapidly progressive necrotizing fasciitis of the perineum and external genitalia that leads to extensive soft tissue necrosis, remains a medical-surgical emergency. The authors present a case of coverage of a scrotal loss of substance with testicular exposure by a medial fasciocutaneous flap of the unilateral thigh after debridement and initial medical treatment of Fournier's gangrene in a 50-year-old quadriplegic patient. The clinical examination at 8 months showed an aesthetic and functional result. Read More

Sci Rep 2022 Apr 21;12(1):6590. Epub 2022 Apr 21.

College of Life Sciences, Jilin Agricultural University, Jilin, China.

Acinetobacter baumannii is a nosocomial bacterial pathogen and is responsible for a wide range of diseases including pneumonia, necrotizing fasciitis, meningitis, and sepsis. The enzyme 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase (encoded by aroA gene) in ESKAPE pathogens catalyzes the sixth step of shikimate pathway. The shikimate pathway is an attractive drug targets pathway as it is present in bacteria but absent in humans. Read More

Actas Dermosifiliogr 2022 Apr 15. Epub 2022 Apr 15.

Servicio de Dermatología, Hospital Universitario Fundación Alcorcón, Alcorcón (Madrid), Spain.

Case Rep Crit Care 2022 6;2022:9291424. Epub 2022 Apr 6.

Department of Nephrology, Temple University Hospital, 3440 N. Broad Street, Kresge West, Suite 100, PA 19004, USA.

Purpura fulminans is a devastating thrombotic disorder infrequently encountered in medical practice and amongst the medical literature. It is a hematologic emergency in which prompt recognition and initiation of treatment are critical to mitigate its significant morbidity and mortality. Surgical evaluation is commonly required, since the debilitating skin and soft tissue necrosis often degenerate into necrotizing fasciitis, critical limb ischemia, warranting surgical interventions in either a staged or single-step approach. Read More

ANZ J Surg 2022 Apr 15. Epub 2022 Apr 15.

Department of General Surgery, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Med Oral Patol Oral Cir Bucal 2022 May 1;27(3):e257-e264. Epub 2022 May 1.

University of Pernambuco, School of Dentistry Oswaldo Cruz University Hospital, Department of Oral and Maxillofacial Surgery Rua Arnóbio Marquês, 310, 50100-130, Santo Amaro, Recife, Pernambuco, Brazil

Background: Liposuction is one of the most commonly performed cosmetic procedures worldwide. Complications associated with submental liposuction are rare. However, when they occur they are significant and can cause disfiguring consequences. Read More

Handchir Mikrochir Plast Chir 2022 Apr 13;54(2):155-159. Epub 2022 Apr 13.

BG-Universitätsklinikum Bergmannsheil Bochum; Klinik für Plastische Chirurgie und Handchirurgie, Schwerbrandverletztenzentrum.

We present the case of a 57-year-old male patient with a fatal outcome after resection of a soft tissue sarcoma of the lateral thigh. A polymicrobial surgical site infection with Staphylococcus lugdunensis and Clostridium perfringens caused fulminant necrotising fasciitis with an additional gas gangrene. The patient suffered a severe sepsis with consecutive haemolysis and multiorgan failure. Read More

Br J Pain 2022 Apr 31;16(2):223-227. Epub 2021 Aug 31.

Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: Necrotizing fasciitis is a rapidly progressive infection of the subcutaneous tissue and fascia with significant morbidity and mortality. There is a paucity of literature published on the benefits of regional anaesthesia in patients with necrotizing fasciitis of the extremities.

Case Presentation: This study demonstrates novel approaches to management of pain in a patient with necrotizing fasciitis of the lower extremity. Read More

J Med Case Rep 2022 Apr 11;16(1):148. Epub 2022 Apr 11.

Department of Hematology and Bone Marrow Transplantation, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal.

Background: Carbapenem-resistant Enterobacteriaceae strains have been reported in healthcare facilities with a rising incidence and are a major concern owing to infections that are often severe and can be potentially fatal, with limited therapeutic options. Klebsiella pneumonia represents the most frequently isolated microorganism.

Case Presentation: We report the case of a Caucasian 52-year old Caucasian woman with acute myeloid leukemia was admitted to the inpatient hematology unit at a university referral hospital in Portugal. Read More

Int J Surg Case Rep 2022 Mar 30;94:106982. Epub 2022 Mar 30.

Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Introduction And Importance: Fournier's gangrene is necrotizing fasciitis of the scrotum and perineal area. It is a polymicrobial infection of perianal origin characterized by rapid necrotizing spread along fascial planes to abdominal wall and flank area. The very rare nature of this illness in neonates makes it important to take a lesson in subsequent management of similar cases. Read More