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    1 OF 87

    Raoultella planticola: A Rare Cause of Wound Infection.
    Wounds 2017 Nov;29(11):E103-E105
    Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. Read More

    Necrotizing fasciitis after high-dose rate brachytherapy and external beam radiation for prostate cancer: a case report.
    BMC Urol 2017 Nov 21;17(1):107. Epub 2017 Nov 21.
    Department of Urology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8509, Japan.
    Background: In recent years, the delayed side effects associated with radiotherapy for prostate cancer have drawn the interest of urologists. Although urosymphyseal fistula is one of these delayed side effects, this serious complication is rarely described in literature and is poorly recognized.

    Case Presentation: We report our experience in treating a 77-year-old male patient with necrotizing fasciitis after high-dose rate brachytherapy plus external beam radiation for prostate cancer. Read More

    Streptococcus pyogenes nuclease A (SpnA) mediated virulence does not exclusively depend on nuclease activity.
    J Microbiol Immunol Infect 2017 Nov 13. Epub 2017 Nov 13.
    Department of Molecular Medicine & Pathology, School of Medical Sciences, University of Auckland, Auckland, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland, New Zealand. Electronic address:
    Background: Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen that causes a wide range of diseases, including pharyngitis, necrotizing fasciitis and toxic shock syndrome. The bacterium produces a large arsenal of virulence factors, including the cell wall-anchored Streptococcus pyogenes nuclease A (SpnA), which facilitates immune evasion by degrading the DNA backbone of neutrophil extracellular traps. SpnA consists of a C-terminal endo/exonuclease domain and a N-terminal domain of unknown function. Read More

    Presentation and Diagnosis of Fournier's Gangrene.
    Urology 2017 Nov 13. Epub 2017 Nov 13.
    Department of Urology, University of Washington School of Medicine, Seattle, WA.
    Necrotizing fasciitis is a severe type of necrotizing soft tissue infection involving the superficial fascia and subcutaneous tissues. Fournier's gangrene, a type of necrotizing fasciitis, affects the genitalia and/or perineum. While a rare health condition, Fournier's gangrene can result in significant morbidity and unnecessary mortality following delay in diagnosis and management. Read More

    Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8720
    Department of Hand Surgery, Wuxi NO.9 People's Hospital Affiliated to Soochow University, Wuxi, China.
    Rationale: Necrotizing fasciitis (NF), characterized by widespread fascial necrosis, is a rare disease in clinic. Fournier gangrene (FG) is a special type of NF involved of perineum and scrotum. To our knowledge, no article has reported on bilateral femoral posterior neurocutaneous perforater flap treating for FG. Read More

    First Necrotizing Fasciitis Caused by Haemophilus influenza Serotype a.
    J Investig Med High Impact Case Rep 2017 Oct-Dec;5(4):2324709617736791. Epub 2017 Oct 25.
    Beaumont Hospital Dearborn, Dearborn, MI, USA.
    Necrotizing fasciitis (NF) is an infrequently encountered skin infection that has high morbidity and mortality, even with prompt medical and surgical intervention. We describe the case of a 67-year-old male presenting with significant NF in his left lower extremity, despite aggressive surgical intervention, and included multiple surgical debridements, ACell Matrix, split-thickness, and negative wound VAC therapy. Ultimately, this patient required a below the knee amputation. Read More

    A case of disseminated cryptococcosis with necrotizing fasciitis in a non-HIV patient.
    Acute Med Surg 2017 Oct 13;4(4):454-457. Epub 2017 Jul 13.
    Division of Clinical ResearchMedical Mycology Research CenterChiba UniversityChibaJapan.
    Case: Disseminated cryptococcosis is a well-recognized condition among HIV patients, but it also occurs in non-HIV patients. Necrotizing fasciitis caused by cryptococcus is rare. An 81-year-old man who had received steroid therapy presented with erythema and pain in his right thigh. Read More

    Whole-Genome Sequencing of a Human Clinical Isolate of emm28 Streptococcus pyogenes Causing Necrotizing Fasciitis Acquired Contemporaneously with Hurricane Harvey.
    Genome Announc 2017 Nov 9;5(45). Epub 2017 Nov 9.
    Center for Molecular and Translational Human Infectious Diseases Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA.
    We discovered an emm28 Streptococcus pyogenes isolate causing necrotizing fasciitis in a patient exposed to the floodwaters of Hurricane Harvey in the Houston, TX, metropolitan area in August 2017. The Oxford Nanopore MinION instrument provided sufficient genome sequence data within 1 h of beginning sequencing to close the genome. Read More

    [Maternal deaths due to infectious cause, results from the French confidential enquiry into maternal deaths, 2010-2012].
    Gynecol Obstet Fertil Senol 2017 Nov 3. Epub 2017 Nov 3.
    Service d'anesthésie-réanimation, hôpital Nord, AP-HM, chemin des Bourrely, 13015 Marseille, France.
    Over the period 2010-2012, maternal mortality from infectious causes accounted for 5% of maternal deaths by direct causes and 16% of maternal deaths by indirect causes. Among the 22 deaths caused by infection occurred during this period, 6 deaths were attributed to direct causes from genital tract origin, confirming thus the decrease in direct maternal deaths by infection during the last ten years. On the contrary, indirect maternal deaths by infection, from extragenital origin, doubled during the same period, with 16 deaths in the last triennium, dominated by winter respiratory infections, particularly influenza: the 2009-2010 influenza A (H1N1) virus pandemic was the leading cause of indirect maternal mortality by infection during the studied period. Read More

    Cervical necrotizing fasciitis: an overlooked diagnosis of a fatal disease.
    Acta Otolaryngol 2017 Nov 6:1-4. Epub 2017 Nov 6.
    a Department of Surgery, College of Medicine and Health Sciences , UAE University , Al Ain , Abu Dhabi , United Arab Emirates.
    Background: Necrotizing fasciitis of the neck is a rare potentially lethal condition if not early diagnosed and managed. We aimed to study the clinical presentation, radiological and microbiological diagnosis, management, and surgical outcome of patients having cervical necrotizing fasciitis (CNF).

    Materials And Methods: We retrospectively studied patients having a final diagnosis of CNF who were treated at Al Ain Hospital during the period of January 2000 to December 2016. Read More

    Immunoglobulin attenuates streptokinase-mediated virulence in Streptococcus dysgalactiae subsp. equisimilis necrotizing fasciitis.
    J Infect Dis 2017 Nov 1. Epub 2017 Nov 1.
    Institute of Intensive Care Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
    Necrotizing fasciitis (NF) retains a very high mortality rate despite prompt and adequate antibiotic treatment and surgical debridement. NF has recently been associated with Streptococcus dysgalactiae subsp. equisimilis (SDSE). Read More

    Necrotizing Fasciitis: How Reliable are the Cutaneous Signs?
    J Emerg Trauma Shock 2017 Oct-Dec;10(4):205-210
    Yong Loo Lin Medical School, National University of, Singapore.
    Necrotizing fasciitis (NF) is a surgical emergency. It is often aggressive and characterized by the rapidly progressive inflammatory infection of the fascia that causes extensive necrosis of the subcutaneous tissue and fascia, relatively sparing the muscle and skin tissue. As the disease progresses, thrombosis of the affected cutaneous perforators subsequently devascularizes the overlying skin. Read More

    Liver abscess and sepsis caused by Clostridium perfringens and Klebsiella oxytoca.
    Int J Surg Case Rep 2017 Oct 26;41:180-183. Epub 2017 Oct 26.
    Department of General, Visceral and Cancer Surgery, HELIOS Klinikum Berlin-Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany. Electronic address:
    Introduction: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i. Read More

    Necrotizing soft tissue infections - a multicentre, prospective observational study (INFECT): protocol and statistical analysis plan.
    Acta Anaesthesiol Scand 2017 Oct 29. Epub 2017 Oct 29.
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Background: The INFECT project aims to advance our understanding of the pathophysiological mechanisms in necrotizing soft tissue infections (NSTIs). The INFECT observational study is part of the INFECT project with the aim of studying the clinical profile of patients with NSTIs and correlating these to patient-important outcomes. With this protocol and statistical analysis plan we describe the methods used to obtain data and the details of the planned analyses. Read More

    A Case of Rituximab-Induced Necrotizing Fasciitis and a Review of the Literature.
    Case Rep Hematol 2017 26;2017:6971027. Epub 2017 Sep 26.
    Department of Medicine, Reading Hospital, West Reading, PA, USA.
    Necrotizing fasciitis is a fulminant soft tissue infection characterized by rapid progression and high mortality. Rituximab is a generally well-tolerated immunosuppresive medication used for B-cell malignancies and some rheumatological disorders. We report a case of a 69-year-old male with chronic lymphocytic leukemia who suffered necrotizing fasciitis of his left lower extremity secondary to Clostridium septicum 7 weeks after treatment with rituximab. Read More

    Necrotizing Fasciitis Secondary to Aeromonas Infection Presenting with Septic Shock.
    Case Rep Med 2017 31;2017:4607582. Epub 2017 Aug 31.
    Department of Internal Medicine and Department of Oncologic Sciences, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
    This report describes a case of necrotizing fasciitis presenting with septic shock due to an Aeromonas infection. The patient cut his foot while mowing the lawn and then spent time in a pool with black mold. He began feeling ill and developed swelling and a quarter-sized black area on his right lower extremity. Read More

    Clinical Mimics: An Emergency Medicine-Focused Review of Cellulitis Mimics.
    J Emerg Med 2017 Oct;53(4):475-484
    Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Cellulitis is a common clinical condition with low rates of morbidity and mortality if treated appropriately. Mimics of cellulitis presenting with erythema, edema, warmth, and pain can be associated with grave morbidity and mortality if misdiagnosed.

    Objective: This review investigates the signs and symptoms of cellulitis, mimics of cellulitis, and an approach to the management of both cellulitis and its mimics. Read More

    Outbreak of invasive infections from subtype emm26.3 group A Streptococcus among homeless adults-Anchorage, Alaska, 2016-2017.
    Clin Infect Dis 2017 Oct 23. Epub 2017 Oct 23.
    Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Zoonotic and Emerging Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, USA.
    Background: In 2016, we detected an outbreak of group A Streptococcus (GAS) invasive infections among the estimated 1000 persons experiencing homelessness (PEH) in Anchorage, Alaska. We characterized the outbreak and implemented a mass antibiotic intervention at homeless service facilities.

    Methods: We identified cases through the Alaska GAS laboratory-based surveillance system. Read More

    Can we predict mortality in patients with necrotizing fasciitis using conventional scoring systems?
    Ulus Travma Acil Cerrahi Derg 2017 Sep;23(5):383-388
    Department of General Surgery, Eskişehir Osmangazi University, Eskişehir-Turkey.
    Background: This study compared the predictive accuracy of four scoring systems, namely Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score II (SAPS II), and Mortality in Emergency Department (MEDS), for estimating prognosis in patients with necrotizing fasciitis.

    Methods: Seventy-four patients who presented with necrotizing fasciitis were retrospectively examined. The ability of the scoring systems to predict mortality was assessed by comparing the estimated mortality rates in mortality groups (survivors/non-survivors), and mortality rates among survivors and non-survivors with an estimated mortality of >10%, 30%, and 50% in the scoring systems were compared in pairs. Read More

    Autologous Platelet-Rich Plasma/Thrombin Gel Combined with Split-Thickness Skin Graft to Manage Postinfectious Skin Defects: A Randomized Controlled Study.
    Adv Skin Wound Care 2017 Nov;30(11):502-508
    Barbara Hersant, MD, is a Plastic Surgeon; Mounia SidAhmed-Mezi, PhD, is a Researcher; Romain Bosc, MD, is a Plastic Surgeon; and Jean-Paul Meningaud, MD, PhD, is Chief, Department of Plastic Cosmetic and Reconstructive Surgery, and is a Plastic and Maxillo-facial Surgeon, Henri Mondor Hospital, Paris, France.
    Background: Managing cutaneous substance loss after debridement is challenging, especially if it is secondary to necrotizing soft tissue infection, such as necrotizing fasciitis and Fournier gangrene. After skin graft reconstruction, the healing process is longer and may be difficult, depending on the wound site, skin defect size, and patient comorbidities.

    Objective: The aim of this study was to investigate whether autologous platelet-rich plasma (A-PRP) could accelerate and improve wound healing after cutaneous reconstruction for tissue loss secondary to soft tissue infection. Read More

    Learning from Clinical Experience with Necrotizing Fasciitis: Treatment and Management.
    Adv Skin Wound Care 2017 Nov;30(11):486-493
    Yukun Liu, PhD • Research Fellow • Tissue Engineering and Wound Healing Lab • Division of Plastic Surgery, Department of Surgery • Brigham and Women's Hospital • Harvard Medical School • Boston, Massachusetts • Resident Doctor of Plastic Surgery • Department of Plastic Surgery • Wuhan Union Hospital • Tongji Medical College • Huazhong University of Science and Technology • Wuhan, China Ke Guo, MD, PhD • Attending Surgeon • Department of Plastic Surgery • Wuhan Union Hospital • Tongji Medical College • Huazhong University of Science and Technology • Wuhan, China Jiaming Sun, MD, PhD • Professor of Plastic Surgery • Department of Plastic Surgery • Wuhan Union Hospital • Tongji Medical College • Huazhong University of Science and Technology • Wuhan, China.
    General Purpose: To provide information about necrotizing fasciitis (NF), how to recognize it, and evidence-based treatment.

    Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

    Learning Objectives/outcomes: After completing this continuing education activity, you should be able to: ABSTRACT: Necrotizing fasciitis is a threatening, rapidly progressive, infectious disease of the soft tissue. Read More

    Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).
    J Innate Immun 2017 Oct 17. Epub 2017 Oct 17.
    Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden.
    The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has been implicated that the translocation of myeloperoxidase (MPO) from neutrophilic granules to the nucleus is crucial to this process. Under disease conditions, however, excessive NET formation can trigger self-destructive complications by releasing pathologic levels of danger-associated molecular pattern molecules (DAMPs). Read More

    Perineal Richter's herniation following proctectomy.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e244-e245. Epub 2017 Sep 15.
    Department of Surgery, Royal Gwent Hospital, Newport , Wales , UK.
    In a Richter's hernia, only part of the anti-mesenteric border of the bowel is incarcerated within the underlying defect. We report three cases presenting between 18 days and 11 years following proctectomy. As all patients had functioning stomas a high index of suspicion is necessary to avoid a delay in diagnosis. Read More

    Necrotising fasciitis of the left leg caused by perforated caecal adenocarcinoma.
    Ann R Coll Surg Engl 2017 Nov 15;99(8):e223-e224. Epub 2017 Sep 15.
    Department of Surgery, School of Medicine, National and Kapodistrian University of Athens , Athens , Greece.
    An 82-year-old man presented with abdominal pain and a painful and swollen left thigh. On examination there was oedema, tenderness and crepitus with skin discoloration of the left thigh. Computed tomography showed retroperitoneal perforation of the caecum and necrotising fasciitis of the left thigh. Read More

    Determining if Positive Predictive Value using Laboratory Risk Indicator for Necrotising Fasciitis is Applicable in Malaysian Patients with Necrotising Fasciitis.
    Malays Orthop J 2017 Jul;11(2):36-39
    Department of Orthopaedics, Hospital Tuanku Ja'afar Seremban, Seremban, Malaysia.
    Introduction: Necrotising fasciitis (NF) is a rapidly progressive infection of the subcutaneous tissue and fascia which spreads rapidly. The scoring system of Laboratory Risk Indicator for Necrotising Fasciitis (LRINEC) developed by Wong et al has been proposed as a tool for distinguishing NF and other soft tissue infections (STI) in Singapore. We set out to establish whether the LRINEC score is applicable in our Malaysian setting. Read More

    Necrotising fasciitis: a ticking time bomb?
    BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.
    Department of Trauma Surgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands.
    Necrotising fasciitis (NF) is a destructive bacterial infection and has often been described in media reports as a 'flesh-eating disease', which if diagnosed late is associated with worse outcome. Unfortunately, diagnosing NF is difficult due to the similar presentation of NF compared with other types of skin and soft tissue infections. The early presentation of NF only shows tenderness, swelling, erythema and warm skin. Read More

    Spondylodiskitis and endocarditis due to Streptococcus gordonii.
    Ann Clin Microbiol Antimicrob 2017 Oct 4;16(1):68. Epub 2017 Oct 4.
    Department of Internal Medicine C, Shaare Zedek Medical Medicine, Affiliated with the Hebrew University-Hadassah Medical School, Jerusalem, Israel.
    Background: Streptococcus gordonii is an infrequent cause of infective endocarditis (IE); associated spondylodiskitis has not yet been described in the literature.

    Purpose: We describe 2 patients who presented with new-onset, severe back pain; blood cultures revealed S. gordonii bacteremia, which led to the diagnosis of spondylodiskitis and IE. Read More

    Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.
    Cell Microbiol 2017 Oct 3. Epub 2017 Oct 3.
    Division of Infection Medicine, Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden.
    Streptococcus pyogenes of the M1 serotype is commonly associated with invasive streptococcal infections and development of streptococcal toxic shock syndrome. The M1 protein is a powerful inducer of inflammatory responses for several human cell types, but the reason why M1 protein-related strains is over-represented in invasive streptococcal diseases is still not understood. This study was undertaken to investigate if soluble M1 protein can aggravate the severity of streptococcal skin infections in respect to inflammation, leucocyte recruitment, and tissue remodelling as seen in patients with cellulitis and necrotizing fasciitis. Read More

    Periorbital Necrotizing Fasciitis Induced by Streptococcus pyogenes: A Case Report and Clarification.
    J Oral Maxillofac Surg 2017 Sep 11. Epub 2017 Sep 11.
    Head of Department and Professor, Division of Stomatology, Maxillo-Facial and Plastic Surgery, Centre Hospitalier Lyon Sud, Pierre Bénite, France.
    Periorbital necrotizing fasciitis (PONF) is a rare condition of the face. PONF can lead to blindness, functional and esthetic sequelae, multiple-organ failure, and death. The aim of this report is to raise the awareness of this severe condition in maxillofacial surgeons. Read More

    Necrotizing fasciitis of the breast managed by partial mastectomy and local tissue rearrangement.
    Case Reports Plast Surg Hand Surg 2017 17;4(1):77-80. Epub 2017 Aug 17.
    Department of General Surgery, St. Elizabeth Health CenterYoungstownOHUSA.
    Necrotizing fasciitis (NF) of the breast is a rare occurrence that is routinely misdiagnosed as an abscess or cellulitis, resulting in treatment delays. A total mastectomy is required when delays occur. We present a 53-year-old female with breast NF managed with a partial mastectomy and local tissue rearrangement. Read More

    Neglected Necrotizing Fasciitis - A Rare Complication of Spinal Anaesthesia.
    J Clin Diagn Res 2017 Aug 1;11(8):PD03-PD04. Epub 2017 Aug 1.
    Professor, Department of General Surgery, PGIMER, Chandigarh, India.
    Necrotizing Fasciitis (NF) is a rare, rapidly progressive severe bacterial soft tissue infection with a high mortality rate. NF classically involves the trunk, groin/perineum, lower limbs, and postoperative wound sites. NF secondary to spinal anaesthesia in a young postpartum female is extremely rare. Read More

    Emergence of multi-drug resistant organisms (MDROs) causing Fournier's gangrene.
    J Infect 2017 Sep 28. Epub 2017 Sep 28.
    Internal Medicine Department, Scripps Mercy Hospital, 4077 Fifth Ave, San Diego, CA 92103; Infectious Disease Division, Scripps Mercy Hospital, 4077 Fifth Ave, San Diego, CA 92103. Electronic address:
    Background: Fournier's gangrene is an uncommon but often devastating infection. There are few contemporary data on the risk factors and evolving microbiologic trends including drug-resistant organisms implicated in these life-threatening infections.

    Methods: A retrospective study of Fournier's gangrene from 2006 to 2015 at a large academic hospital was conducted. Read More

    Procalcitonin: A Powerful Rescuer on Surgical Floors.
    Cureus 2017 Jul 8;9(7):e1446. Epub 2017 Jul 8.
    Fmh College of Medicine, FMH College of Medicine.
    Necrotizing fasciitis (NF) is a rare but life-threatening medical and surgical emergency. It is characterized by necrosis of the soft tissue leaving the overlying tissue unaffected, which delays the diagnosis and treatment. Delay in recognition of the severity of necrotizing fasciitis might lead to serious morbidity and mortality. Read More

    Necrotizing fasciitis of the lower leg caused by Escherichia coli, and an association with pyogenic spondylitis.
    Clin Exp Dermatol 2017 Dec 19;42(8):918-920. Epub 2017 Sep 19.
    Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

    Linoleic and palmitoleic acid block streptokinase-mediated plasminogen activation and reduce severity of invasive group A streptococcal infection.
    Sci Rep 2017 Sep 18;7(1):11798. Epub 2017 Sep 18.
    Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Saarbrücken, Germany.
    In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria are capable to hide from them very quickly. Therefore, new remedies are urgently needed. Read More

    Group A Streptococcal bacteraemia. Experience at King Fahad Medical City in Riyadh, Saudi Arabia.
    Saudi Med J 2017 Oct;38(10):1034-1037
    Pediatric Infectious Diseases Section, Children's Specialized Hospital, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia. E-mail.
    Objectives: To identify clinical presentation, predisposing factors, and the outcome in patients with Group A Streptococcal bacteremia. Methods: This is a retrospective study of 33 pediatric and adult patients with Streptococcus pyogenes bacteremia, admitted at King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia from 2007 to 2015. Results: Thirty-three patient records, documenting bacteremia with group A beta-hemolytic streptococcus, were reviewed. Read More

    Cellulitis in aged persons: a neglected infection in the literature.
    Pan Afr Med J 2017 30;27:160. Epub 2017 Jun 30.
    Department of Internal Medicine, Sahloul Hospital, Faculty of Medicine of Sousse, Sousse, Tunisia.
    Cellulitis is a frequent soft tissue and skin infection. The lower limbs are affected in 70 to 80% of cases. Cellulitis in aged persons is not yet well described in literature. Read More

    Treatment of Staphylococcus aureus Infections.
    Curr Top Microbiol Immunol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Pediatrics, The University of Chicago, 5841 S. Maryland Ave., MC6054, Chicago, IL, 60637, USA.
    Staphylococcus aureus, although generally identified as a commensal, is also a common cause of human bacterial infections, including of the skin and other soft tissues, bones, bloodstream, and respiratory tract. The history of S. aureus treatment is marked by the development of resistance to each new class of antistaphylococcal antimicrobial drugs, including the penicillins, sulfonamides, tetracyclines, glycopeptides, and others, complicating therapy. Read More

    Presenting features of extremity necrotizing fasciitis in the pediatric patient: a case-control analysis.
    J Pediatr Orthop B 2017 Sep 4. Epub 2017 Sep 4.
    aDepartment of Orthopedics, Rady Children's Hospital and Health Center bDepartment of Orthopaedic Surgery, University of California, San Diego, California, USA.
    This analysis sought to develop a tool for early differentiation between pediatric necrotizing fasciitis (NF) of the extremity and more benign infection. All diagnoses of extremity NF, cellulitis, and abscess from a single institution from 2009 to 2015 were included. Vitals and laboratory values were compared between cohorts using analysis of variance and decision tree analysis. Read More

    A case of bisphosphonate-related osteonecrosis of the jaw with a particularly unfavourable course: a case report.
    J Korean Assoc Oral Maxillofac Surg 2017 Aug 24;43(4):272-275. Epub 2017 Aug 24.
    Department of Medicine, Surgery and Neurosciences, ENT Clinic, University of Siena, Siena, Italy.
    Bisphosphonates are drugs used to treat osteoclast-mediated bone resorption, including osteoporosis, Paget disease, multiple myeloma, cancer-related osteolysis, and malignant hypercalcemia. The use of these drugs has increased in recent years as have their complications, especially bisphosphonate-related osteonecrosis of the jaw (BRONJ), which more frequently affects the mandible. Here we report a case of BRONJ with a particularly unfavorable course due to cervical inflammation that developed into necrotizing fasciitis, followed by multiorgan involvement leading to septic shock and death. Read More

    Magnetic Resonance Imaging of Musculoskeletal Emergencies.
    Semin Ultrasound CT MR 2017 Aug 5;38(4):439-452. Epub 2017 Apr 5.
    Department of Radiology, Baystate Medical Center, University of Massachusetts, Springfield, MA.
    Musculoskeletal trauma and infections are commonly encountered in the emergency department. Magnetic resonance imaging (MRI) is rarely employed in true emergencies and most musculoskeletal studies can be deferred to the outpatient setting. This article seeks to address the urgent conditions in which MRI can play a role in diagnosis, management, and treatment. Read More

    Negative Pressure Wound Therapy for a Giant Wound Secondary to Malignancy-induced Necrotizing Fasciitis: Case Report and Review of the Literature.
    Wounds 2017 Aug;29(8):E55-E60
    Division of Plastic & Reconstructive Surgery, McMaster University, Hamilton, Ontario, Canada.
    Background: Necrotizing fasciitis (NF) is a life-threatening condition in which rapid diagnosis, debridement of nonviable tissue, and broad-spectrum antibiotics are critical to effective treatment. The debridement required can be extensive, resulting in large wounds that can sometimes be covered with split-thickness skin grafts (STSGs) with the help of negative pressure wound therapy (NPWT), or vacuum-assisted closure, to decrease the wound size.

    Case Report: The authors report a rare case of NF due to malignancy-associated bowel perforation with a giant lower extremity wound secondary to debridement that involved 20% of the total body surface area (TBSA) in a 64-year-old, previously healthy, nonsmoking man. Read More

    Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene.
    Turk J Urol 2017 Sep 1;43(3):366-370. Epub 2017 Aug 1.
    Clinic of Plastic Surgery, Antalya Training and Research Hospital, Antalya, Turkey.
    Objective: Fournier's gangrene is an infective necrotizing fasciitis of the perineal, genital and perianal regions. Treatment includes aggressive surgical debridement that often results in extensive loss of genital skin. Skin grafts may be used for reconstruction but skin grafting of the male genitalia is diffucult because the penis and scrotum are mobile and deformable. Read More

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