4,587 results match your criteria Necrotizing Fasciitis


A case report of successful treatment of necrotizing fasciitis using negative pressure wound therapy.

Medicine (Baltimore) 2019 Jan;98(2):e13283

Residência Multiprofissional em Cuidados Continuados Integrados.

Rationale: Necrotizing fasciitis is a destructive tissue infection with rapid progression and high mortality. Thus, it is necessary that high-performance dressings be introduced as possibilities of treatment.

Patient Concerns: Female patient, 44 years of age, admitted to hospital unit complaining of lesion in the gluteal region and drainage of purulent secretion in large quantity followed by necrosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013283DOI Listing
January 2019

Fournier's Gangrene With Septic Shock and Multiple Organ Dysfunction Syndrome.

Int J Low Extrem Wounds 2019 Jan 8:1534734618818685. Epub 2019 Jan 8.

1 Ruijin Hospital, Shanghai Jiaotong University, Shanghai, People's Republic of China.

Fournier's gangrene is a rare, rapidly progressing, and life-threatening infection associated with necrotizing fasciitis in the perineal, genital, and/or lower abdominal regions. Septic shock and multiple organ dysfunction syndrome due to the condition are even rarer events. We describe the case of a 58-year-old man who visited the emergency department with severely painful swelling in the scrotal, perianal, and lower abdominal regions. Read More

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http://dx.doi.org/10.1177/1534734618818685DOI Listing
January 2019

The Use of Negative Pressure with Instillation and Dwell for the Treatment of Necrotizing Fasciitis.

Cureus 2018 Oct 29;10(10):e3515. Epub 2018 Oct 29.

Wound, Ostomy, Continence Care / Nursing Administration, Reading Health System, Reading, USA.

The human body is a complex, multisystem organism that can manifest disease processes in a multitude of ways. Over the decades, technological advancements have allowed us to make precise diagnoses so that clinicians can thoroughly treat the underlying cause. Frequently these disease processes require surgical intervention to eliminate the progression and provide the patient with positive outcomes. Read More

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https://www.cureus.com/articles/15324-the-use-of-negative-pr
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http://dx.doi.org/10.7759/cureus.3515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314792PMC
October 2018
1 Read

Utilizing Negative Pressure Wound Therapy with Instillation and Dwell Time for Extensive Necrotizing Fasciitis of the Lower Extremity: A Case Report.

Cureus 2018 Oct 23;10(10):e3483. Epub 2018 Oct 23.

Orthopedic Surgery, Queen's Medical Center, Honolulu, USA.

Necrotizing fasciitis is a rapidly spreading infection of the soft tissue, which carries significant morbidity and mortality. This condition is treated with broad-spectrum antibiotics, irrigation and surgical debridement of the affected area, and hemodynamic support. Negative pressure wound therapy (NPWT) has been utilized after surgical debridement to promote wound healing, especially when significant debridement has occurred. Read More

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https://www.cureus.com/articles/15314-utilizing-negative-pre
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http://dx.doi.org/10.7759/cureus.3483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314797PMC
October 2018
2 Reads

Acute promyelocytic leukaemia presenting as necrotising fasciitis of the perineum (Fournier gangrene).

BMJ Case Rep 2018 12 7;11(1). Epub 2018 Dec 7.

Department of Hematology and Oncology, Boston Medical Center, Boston, Massachusetts, USA.

We present a case of an unusual presentation of acute promyelocytic leukaemia (APML), which presented with Fournier gangrene (FG). A 38-year-old man presented with malaise, groin swelling, anal bleeding, fever and was found to have FG. Initial workup revealed pancytopaenia, borderline low fibrinogen, prolonged international normalized ratio (INR), which raised the suspicion for leukaemia. Read More

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http://dx.doi.org/10.1136/bcr-2018-226837DOI Listing
December 2018
3 Reads

Cervicofacial necrotising fasciitis by clindamycin-resistant and methicillin-resistant (MRSA) in a young healthy man.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Otolaryngology - Head and Neck Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

An otherwise healthy 24-year-old man presented with 1 week of fever, facial pain and swelling. He initially sought care at an outside hospital, where he was diagnosed with folliculitis and sent home with oral antibiotics. On arrival at our institution, CT neck was ordered, which demonstrated diffuse submental phlegmon, prompting incision and drainage. Read More

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http://dx.doi.org/10.1136/bcr-2018-226975DOI Listing
November 2018

Hypermucoviscous capsular 1 (K1) serotype necrotising fasciitis and metastatic endophthalmitis.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Section of Infectious Diseases, Department of Medicine, College of Medicine & Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

A 48-year-old man presented with a non-healing wound on his left foot after stepping on a nail. He self-medicated with amoxicillin, but the wound progressed prompting consult. On examination, his left foot was diffusely swollen with surrounding erythema, areas of gangrene, foul-smelling purulent discharge and subcutaneous emphysema. Read More

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http://dx.doi.org/10.1136/bcr-2018-226096DOI Listing
November 2018
1 Read

Focal Myositis of the Leg Presenting as Fever of Unknown Origin Detected by FDG PET/CT.

Clin Nucl Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Pathology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Focal myositis is an uncommon inflammatory pseudotumor of the skeletal muscle that may mimic neoplastic and inflammatory diseases. We present one case of focal myositis involving the left proximal vastus lateralis and vastus intermedius, and left soleus showing intense FDG uptake on FDG PET/CT. This case indicates that focal myositis should be considered as a differential diagnosis in patients with focal hypermetabolic muscular lesions, including benign and malignant tumors, necrotizing autoimmune myopathy, nodular fasciitis, myositis ossificans, and muscular sarcoidosis. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9731
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http://dx.doi.org/10.1097/RLU.0000000000002427DOI Listing
December 2018
7 Reads

Necrotizing Myositis: A Rare Necrotizing Soft Tissue Infection Involving Muscle.

Wounds 2018 Dec;30(12):E116-E120

Department of Surgery, NYU Winthrop Hospital, Mineola, NY.

Introduction: Necrotizing myositis (NM) is an extremely rare necrotizing soft tissue infection involving muscle. Unlike similar infections (eg, necrotizing fasciitis, clostridial myonecrosis) that can be more readily diagnosed, NM can have a benign presentation then rapidly progress into a life-threatening condition with a mortality rate of 100% without surgical intervention.

Case Report: A 74-year-old man with a history of prostate cancer with radiation therapy, seed implants, and 2 transurethral resection procedures presented to the emergency department after a fall. Read More

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December 2018
9 Reads

Pathogenesis of Hypervirulent Group A Streptococcus.

Jpn J Med (Lond) 2018 ;1(6):269-275

Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59718, USA.

Group A (GAS) causes common pharyngitis and skin infections and occasional severe invasive infections. This review describes the recent progress on the pathogenesis of hypervirulent GAS. CovRS mutations are frequent among invasive GAS isolates and lead to hypervirulence. Read More

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http://dx.doi.org/10.31488/jjm.1000127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294136PMC
January 2018
4 Reads

A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus.

Infez Med 2018 Dec;26(4):359-363

Laboratory Medicine, San Bassiano Hospital, AULSS 7 Pedemontana, Bassano del Grappa, Italy.

Diabetes mellitus is one of the serious conditions associated with necrotizing fasciitis, a severe bacterial skin infection that spreads quickly and is characterized by extensive necrosis of the deep and superficial fascia resulting in devascularization and necrosis of the associated tissues. In addition to debridement and aggressive surgery procedures, the effectiveness of therapy depends on choosing the appropriate antibacterial agents. Hence the key to successful management is an early and accurate diagnosis. Read More

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December 2018

Necrotizing fasciitis following colonoscopy in the setting of ulcerative colitis.

ANZ J Surg 2018 Dec 9. Epub 2018 Dec 9.

Department of Plastic and Reconstructive Surgery, Peninsula Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/ans.14882DOI Listing
December 2018

Group A streptococcal DNase Sda1 impairs plasmacytoid dendritic cell's type I interferon response.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address:

Group A Streptococcus causes severe invasive infections, including necrotizing fasciitis. The expression of an array of virulence factors targeting specific host immune functions impedes successful bacterial clearance. The virulence factor streptococcal DNase Sda1 was previously shown to interfere with the entrapment of bacteria through neutrophil extracellular traps and TLR9 signaling. Read More

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http://dx.doi.org/10.1016/j.jid.2018.11.027DOI Listing
December 2018
4 Reads

High mortality of non-Fournier necrotizing fasciitis with Enterobacteriales: time to rethink classification?

Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

Clinical Microbiology, University Hospital Basel, Basel, Switzerland.

This cohort study describes mortality predictors of necrotizing fasciitis (NF). Higher age, chronic kidney disease and higher Charlson score increased mortality rate. Mortality was more than three times higher in monomicrobial gram-negative NF than in type I or type II NF. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy1011DOI Listing
December 2018
5 Reads

Complex abdominopelvic reconstruction by combined tensor fascia latae and superficial circumflex iliac artery perforator flaps.

Microsurgery 2018 Dec 3. Epub 2018 Dec 3.

Department of Plastic, Reconstructive, Aesthetic Surgery and Burns, CHRU Rangueil, Toulouse, France.

Background: Extensive full thickness abdominopelvic defects pose a difficult challenge to surgeons. Autologous tissues are versatile and can provide a satisfying reconstructive option for this type of defects. The tensor fascia latae (TFL) and superficial circumflex iliac perforator (SCIP) flaps provide a large area of vascularized tissue and their use in reconstructive surgery is well-known. Read More

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http://doi.wiley.com/10.1002/micr.30391
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http://dx.doi.org/10.1002/micr.30391DOI Listing
December 2018
4 Reads

Fatal Streptoccocus canis Necrotizing Fasciitis and Myositis in a Free-Ranging Iberian Lynx ( Lynx pardinus).

J Wildl Dis 2018 Dec 3. Epub 2018 Dec 3.

7 Dirección General de Medio Ambiente, Junta de Extremadura, Avda. de Luis Ramallo s/n, 06800 Mérida (Badajoz), Spain.

A free-ranging Iberian lynx ( Lynx pardinus) was found dead after 16 mo of being reintroduced. On gross necropsy, necrotic areas in the left biceps femoris and intercostal muscles were identified. Streptococcus canis was isolated from both groups of muscles and was confirmed by PCR, corroborating a necrotizing myositis diagnostic. Read More

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http://dx.doi.org/10.7589/2018-05-135DOI Listing
December 2018
5 Reads

Analysis of prognostic factors affecting poor outcomes in 41 cases of Fournier gangrene.

Ann Surg Treat Res 2018 Dec 26;95(6):324-332. Epub 2018 Nov 26.

Department of Plastic and Reconstructive Surgery, Ajou University School of Medicine, Suwon, Korea.

Purpose: We present our experience involving the management of this disease, identifying prognostic factors affecting treatment outcomes.

Methods: The patients treated for Fournier gangrene at our institution were retrospectively reviewed. Data collected included demographics, extent of soft tissue necrosis, predisposing factors, etiological factors, laboratory values, and treatment outcomes. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4174/astr.2018.9
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http://dx.doi.org/10.4174/astr.2018.95.6.324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255751PMC
December 2018
5 Reads

Investigation of the virulence and genomics of Aeromonas salmonicida strains isolated from human patients.

Infect Genet Evol 2018 Nov 28;68:1-9. Epub 2018 Nov 28.

Université Laval, Quebec City, QC, Canada. Electronic address:

The bacterium Aeromonas salmonicida is known since long time as a major fish pathogen unable to grow at 37 °C. However, some cases of human infection by putative mesophilic A. salmonicida have been reported. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.11.019DOI Listing
November 2018
1 Read

Recognizing Common Skin and Soft Tissue Infections in the Nephrology Clinic.

Blood Purif 2018 Dec 5:1-6. Epub 2018 Dec 5.

Renal failure patients have an increased risk of infection, including skin and soft tissue infections. This increased susceptibility is multifactorial, due to the conditions causing the renal failure as well as complications of treatment and renal failure's innate effects on patient health. These infections have a significant impact on patient morbidity, increased hospital and procedural demands, and the cost of health care. Read More

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http://dx.doi.org/10.1159/000494594DOI Listing
December 2018
9 Reads

Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis.

Case Rep Surg 2018 28;2018:8260968. Epub 2018 Oct 28.

Department of Surgery, Kensei Hospital, Hirosaki-shi, Aomori, Japan.

Streptococcal toxic shock syndrome (STSS) is a life-threatening disease caused by infection of . Here, we report an uncommon case of STSS with both diffuse peritonitis and necrotizing fasciitis and summarize previous cases. The patient was diagnosed with STSS due to an infection of the soft tissue of the lower extremity after surgery for diffuse peritonitis. Read More

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http://dx.doi.org/10.1155/2018/8260968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230428PMC
October 2018
1 Read

Cervicofacial Necrotizing Fasciitis in Patients with No Underlying Medical Conditions: A Review of Four Cases Seen in Twelve Months at a Nigerian Tertiary Hospital.

Iran J Med Sci 2018 Nov;43(6):653-658

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Lagos State University College of Medicine, Lagos State, Nigeria.

Necrotizing fasciitis of the head and neck is a rare but rapidly progressive infection involving the skin, subcutaneous tissue, and fascia. We report 4 cases of cervicofacial necrotizing fasciitis with similar patterns of presentation. All the 4 cases presented with an odontogenic source and no underlying medical condition. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230931PMC
November 2018
2 Reads

The Effect of Body Weight Support on Energy Expenditure in an Individual With High-Level Lower Extremity Amputation.

Phys Ther 2018 Nov 28. Epub 2018 Nov 28.

Philadelphia College of Osteopathic Medicine, 625 Old Peachtree Rd NW, Suwanee, GA 30024 (USA).

Background: High-level lower extremity amputation (HLLEA) has significant impact on an individual's ability to ambulate and maintain cardiovascular fitness for extended periods of time.

Objective: The purpose of this study was to evaluate whether body weight support (BWS) would improve energy efficiency in an individual with HLLEA in order to achieve appropriate target cardiovascular intensity for aerobic training.

Design: This is an exploratory single-subject study. Read More

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http://dx.doi.org/10.1093/ptj/pzy147DOI Listing
November 2018
1 Read

Recurrent group A streptococcal severe sepsis in the postpartum period.

Int J Gynaecol Obstet 2019 Feb 13;144(2):235-236. Epub 2018 Dec 13.

Transbaikal Regional Hospital, Chita, Russia.

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http://dx.doi.org/10.1002/ijgo.12725DOI Listing
February 2019
2 Reads

Necrotizing fasciitis of the thigh due to penetrated descending colon cancer: a case report.

Surg Case Rep 2018 Nov 26;4(1):136. Epub 2018 Nov 26.

Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

Background: Necrotizing fasciitis (NF) caused by colorectal cancer is rare, and very few cases associated with colon cancer have been reported. We describe the case of a patient with NF in the left thigh due to penetration of descending colon cancer who was treated with one-stage surgical resection without creating a stoma.

Case Presentation: An 80-year-old woman was brought to our hospital complaining of fever and difficulty with body movement. Read More

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http://dx.doi.org/10.1186/s40792-018-0544-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261093PMC
November 2018
1 Read

Fasciitis necrotisans - duplicitas casuum.

Rozhl Chir 2018 ;97(9):432-441

Necrotizing fasciitis is a dangerous bacterial infectious disease that is not commonplace in Czech society. On the other hand, neither is it so rare that the majority of surgeons should not come across it occasionally. In the early stages, pathological changes in fascia, subcutaneous tissue and even skin may run an inconspicuous course. Read More

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January 2018
10 Reads

Application of a paste-type acellular dermal matrix for coverage of chronic ulcerative wounds.

Arch Plast Surg 2018 Nov 15;45(6):564-571. Epub 2018 Nov 15.

Department of Plastic and Reconstructive Surgery, Sanggye Paik Hospital, Inje University School of Medicine, Seoul, Korea.

Background: Chronic wounds occur due to failure of the normal healing process, associated with a lack of deposition of cellular components and a suitable microenvironment such as the extracellular matrix (ECM). Acellular dermal matrix (ADM) is viewed as an ECM substitute, and a paste-type ADM has recently been introduced. We hypothesized that CGPaste, an injectable paste-type ADM, could serve as a scaffold and promote wound healing. Read More

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http://dx.doi.org/10.5999/aps.2018.00605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258976PMC
November 2018
8 Reads

Fatal orbital necrotizing fasciitis secondary to stenotrophomonas maltophilia associated stomatitis.

J Stomatol Oral Maxillofac Surg 2018 Nov 19. Epub 2018 Nov 19.

Recep Tayyip Erdogan University, Department of Pathology, Rize, Turkey.

An 81-year-old woman with diabetes mellitus presented with signs of orbital cellulitis and a gangrenous ulcer on the right palate. Biopsy analysis confirmed a diagnosis of necrotizing fasciitis. Surgical debridement of necrotic tissues and enucleation of the right eye were performed. Read More

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http://dx.doi.org/10.1016/j.jormas.2018.11.004DOI Listing
November 2018
11 Reads

Diagnostic pitfalls in the differentiation between pyoderma gangrenosum and necrotizing fasciitis.

Acta Orthop Belg 2018 Mar;84(1):17-24

Pyoderma gangrenosum and necrotizing fasciitis are two rare pathologic entities with a similar clinical image, but a who require a very different management. In general physicians, orthopedics, dermatologists, plastic surgeons will hardly ever see it, but when they do it is very important to distinguish between both. In this paper with the focus on the practical approach ,we expose the diagnostic pitfalls in the differential diagnosis, explain how to prevent them and summarize the evidence on therapeutic management. Read More

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March 2018
1 Read

A New Bacterium, , Causing Necrotizing Fasciitis.

Am Surg 2018 Feb;84(2):e61-e63

Saint Mary's Hospital, Waterbury, Connecticut, USA.

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February 2018

Fungal Necrotizing Fasciitis after Penetrating Trauma.

Am Surg 2018 Aug;84(8):e302-e304

Division of General Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

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August 2018
1 Read

Community-acquired Disseminated Exophiala dermatitidis Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, Fukuoka University Hospital, Japan.

We herein report a case of systemic phaeohyphomycosis by Exophiala dermatitidis (E. dermatitidis) with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The patient had been taking oral corticosteroids for years to control the GVHD. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1706-18DOI Listing
November 2018
7 Reads

Necrotizing fasciitis caused by in an immunocompromised patient.

J Surg Case Rep 2018 Nov 13;2018(11):rjy294. Epub 2018 Nov 13.

Division of Surgery, R Adams Cowley Shock Trauma Center, Baltimore, USA.

This case report describes an immunocompromised patient with a skin boil that progressed to necrotizing fasciitis. The aim of this brief report is to raise awareness regarding necrotizing soft tissue infections caused by an unusual organism, , a typically non-pathogenic organism, and outline the course of treatment currently considered to be the standard of care. Read More

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http://dx.doi.org/10.1093/jscr/rjy294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232278PMC
November 2018

Primitive necrotizing fasciitis of the thoracic wall: Fatal complication of diabetic patient.

Tunis Med 2018 Aug - Sep;96(8-09):520-523

Introduction: necrotizing fasciitis of the chest wall is a rare condition in subcutaneous tissues and deep fascia. Primary thoracic involvement is exceptional and is a diagnostic and therapeutic emergency.

Aim: To report our experience in the management of this rare pathology of which clinical picture is unknown by most practitioners. Read More

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November 2018
1 Read

Necrotizing Fasciitis of the Breast: Case Report with Literature Review.

Case Rep Surg 2018 23;2018:1370680. Epub 2018 Oct 23.

Department of General Surgery, Al-Noor Specialist Hospital, Makkah, Saudi Arabia.

Necrotizing fasciitis is a life-threatening aggressive soft tissue infection which usually affects the extremities, abdominal wall, or perineum. Breasts are rarely affected, with most cases presenting after trauma or surgical intervention. It may be misdiagnosed as abscess or cellulitis, leading to treatment delays. Read More

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https://www.hindawi.com/journals/cris/2018/1370680/
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http://dx.doi.org/10.1155/2018/1370680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218748PMC
October 2018
4 Reads

Diagnostic Performance of Initial Serum Albumin Level for Predicting In-Hospital Mortality among Necrotizing Fasciitis Patients.

J Clin Med 2018 Nov 10;7(11). Epub 2018 Nov 10.

Department of Emergency Medicine, Chang Gung Memorial Hospital, No.6, Sec. W., Jiapu Rd., Puzi City, Chiayi County 613, Taiwan.

Background: Hypoalbuminemia is known to be associated with adverse outcomes in critical illness. In this study, we attempted to identify whether hypoalbuminemia on emergency department (ED) arrival is a reliable predictor for in-hospital mortality in necrotizing fasciitis (NF).

Patients:

Method: A retrospective cohort study of hospitalized adult patients with NF was conducted in a tertiary teaching hospital in Taiwan between March 2010 and March 2018. Read More

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http://www.mdpi.com/2077-0383/7/11/435
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http://dx.doi.org/10.3390/jcm7110435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262451PMC
November 2018
7 Reads

Is lymphatic reconstitution possible after meshed skin grafting?

Lymphology 2018 ;51(3):132-135

Australian Lymphoedema Education Research Treatment (ALERT), Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

Restorative potential of lymph transport after skin graft has rarely been discussed. We report a case of lymphatic reconstitution across meshed, split-thickness skin graft performed for a patient with necrotizing fasciitis. The patient underwent extensive circumferential soft tissue debridement of the lower leg and resurfacing of the skin defect with meshed split-thickness skin graft. Read More

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January 2018
13 Reads

Necrotizing Fasciitis: An Overview and 2 Illustrative Cases.

Int J Low Extrem Wounds 2018 Dec 13;17(4):295-300. Epub 2018 Nov 13.

3 Hermans Consulting LLC, Doral, FL, USA.

Necrotizing fasciitis is the generic term for a series of progressive gangrenous infections of the skin and subcutaneous tissues. Typically, necrotizing fasciitis start with an, often small, infected lesion with atypical symptoms, which then quickly develops into a rapidly spreading, massive infection. The primary therapy is excision of all necrotic tissue in combination with treatment of systemic symptoms such as shock. Read More

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http://journals.sagepub.com/doi/10.1177/1534734618804037
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http://dx.doi.org/10.1177/1534734618804037DOI Listing
December 2018
4 Reads

Intestinal Perforation by a Toothpick as Reason for Necrotizing Fasciitis.

J Bone Jt Infect 2018 4;3(4):226-229. Epub 2018 Oct 4.

University Hospital Giessen and Marburg, Campus Giessen, Department of Trauma, Hand and Reconstructive Surgery, Rudolf-Buchheim-Strasse 7, 35385 Giessen, Germany.

Necrotizing fasciitis is an uncommon but often fatal disease. Given the various causes of necrotizing fasciitis, we report a case of sigmoid colon perforation caused by a toothpick subsequently resulting in fulminant necrotizing fasciitis of the retroperitoneum and right thigh successfully treated by hemipelvectomy and Hartmann´s procedure. Read More

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http://dx.doi.org/10.7150/jbji.29065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215990PMC
October 2018
1 Read

Group A disease in Hong Kong children: an overview.

Hong Kong Med J 2018 Nov 9. Epub 2018 Nov 9.

Department of Paediatrics, Alberta Children's Hospital, The University of Calgary, Calgary, Alberta, Canada.

Group A β-haemolytic or is a gram-positive coccus that tends to grow in chains. is the cause of many important human diseases, ranging from pharyngitis and mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Read More

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http://dx.doi.org/10.12809/hkmj187275DOI Listing
November 2018
3 Reads

Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience.

Surg Infect (Larchmt) 2019 Jan 7;20(1):78-82. Epub 2018 Nov 7.

Faculty of Medicine, Department of General Surgery, Kirikkale University , Kirikkale, Turkey .

Background: The objective of this study was to determine the clinical and laboratory features affecting mortality in Fournier gangrene.

Patients And Methods: This retrospective case control study was designed to evaluate patients treated for Fournier gangrene in our center between 2010 and 2018. Those patients were divided into two groups: discharged patients (group 1) and deceased patients (group 2). Read More

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https://www.liebertpub.com/doi/10.1089/sur.2018.208
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http://dx.doi.org/10.1089/sur.2018.208DOI Listing
January 2019
8 Reads

Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections.

Biomed Pharmacother 2019 Jan 3;109:440-447. Epub 2018 Nov 3.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Hyperbaric oxygen therapy (HBOT) is a treatment procedure that involves breathing 100% O for a certain time and under a certain pressure. HBOT is commonly administrated as a primary or alternative therapy for different diseases such as infections. In this paper, we reviewed the general aspect of HBOT procedures, the mechanisms of antimicrobial effects and the application in the treatment of infections. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.142DOI Listing
January 2019
1 Read

Micafungin-Induced Hypoglycemia in a Type 1 Diabetes Patient: A Case Report and Review of Literature.

J Clin Endocrinol Metab 2018 Nov 5. Epub 2018 Nov 5.

Division of Endocrinology and Diabetes, Rush University Medical Center, Chicago, IL, USA.

Objective: Patients with type 1 diabetes mellitus (T1DM) are insulin-dependent. Infection increases insulin resistance and subsequently increases insulin needs. We are reporting the first case of a patient with T1DM and severe infection who has reduced insulin needs after starting micafungin therapy. Read More

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https://academic.oup.com/jcem/advance-article/doi/10.1210/jc
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http://dx.doi.org/10.1210/jc.2018-02017DOI Listing
November 2018
10 Reads

Clinical Features of Neutrophilic Dermatosis Variants Resembling Necrotizing Fasciitis.

JAMA Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Department of Dermatology, University of California San Francisco, San Francisco.

Importance: Pyoderma gangrenosum and necrotizing Sweet syndrome are diagnostically challenging variants of neutrophilic dermatosis that can clinically mimic the cutaneous and systemic features of necrotizing fasciitis. Improved characterization of these rare variants is needed, as improper diagnosis may lead to inappropriate or delayed treatment and the potential for morbidity.

Objective: To determine the characteristics of necrotizing neutrophilic dermatosis to improve diagnostic accuracy and distinguish from infection. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.3890DOI Listing
October 2018
6 Reads

Multidrug-resistant Aeromonas hydrophila causing fatal bilateral necrotizing fasciitis in an immunocompromised patient: a case report.

J Med Case Rep 2018 Nov 1;12(1):326. Epub 2018 Nov 1.

Department of Medicine, University of Calgary, 9-3535 Research Rd NW, Calgary, AB, T2L 2K8, Canada.

Background: Aeromonas hydrophila is a water-dwelling, gram-negative rod-shaped bacterium, associated with diarrheal illness and, less commonly, necrotizing skin and soft tissue infections, especially among immunocompromised patients. Necrotizing fasciitis is associated with a high mortality rate, especially when caused by Aeromonas spp. Our patient was infected with an extremely aggressive form of multidrug-resistant Aeromonas spp. Read More

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http://dx.doi.org/10.1186/s13256-018-1854-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211551PMC
November 2018
2 Reads

Streptococcal toxic shock syndrome in a returning traveller.

Acta Clin Belg 2018 Oct 27:1-5. Epub 2018 Oct 27.

c Center for Infectious Diseases ID4C , Military Hospital Queen Astrid , Brussels , Belgium.

Background:  A patient presenting with fever and purpura after a stay in the tropics tempts a physician to make a differential diagnosis mainly focusing on imported diseases. Although the importance of considering a tropical disease is obvious, the fact that cosmopolitan infections account for one third of the cases in a febrile returning traveler must not be overseen. Toxic Shock Syndrome is amongst the most notorious diseases due to the high mortality when inappropriately managed and the association with necrotizing fasciitis. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2018.1
Publisher Site
http://dx.doi.org/10.1080/17843286.2018.1539634DOI Listing
October 2018
6 Reads

Necrotizing fasciitis of chest and right abdominal wall caused by acute perforated appendicitis: Case report.

Int J Surg Case Rep 2018 4;53:32-34. Epub 2018 Oct 4.

Department of Anesthesiology and Critical Care Medicine, Burns and Trauma Center, Ben Arous, Tunisia. Electronic address:

Introduction: Necrotizing fasciitis is an uncommon infection characterized by a necrotic infection that rapidly diffuse along the fascia and progresses to systemic sepsis. The combined occurrence of necrotizing fasciitis of the chest wall and acute appendicitis is extremely unusual.

Case Presentation: A 27-year-old man without any significant medical history presented to the emergency department, in the postoperative course of a laparotomy for perforated acute appendicitis, with septic shock and a large erythematous region over the right abdominal wall. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183040
Publisher Site
http://dx.doi.org/10.1016/j.ijscr.2018.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205061PMC
October 2018
7 Reads

[Infección necrotizante de la pared abdominal: ¿qué hacer?]

Cir Cir 2018 ;86(6):570-574

Servicio de Anestesiología y Reanimación. Hospital Universitario de Cabueñes, Gijón, España.

El éxito en el tratamiento de las infecciones necrotizantes de los tejidos blandos (INTB) depende de la precocidad diagnóstica y de la agresividad terapéutica, basada en el desbridamiento quirúrgico, la antibioticoterapia de amplio espectro y el soporte intensivo. Se presenta un caso de INTB secundaria a diverticulitis aguda perforada (Hinchey 4) con el fin de ilustrar las consideraciones particulares en el manejo de la INTB de localización en la pared abdominal, apoyadas en la evidencia disponible en la literatura científica. Se identifican como puntos clave la precocidad y la agresividad del desbridamiento quirúrgico, la antibioticoterapia dirigida por el cultivo y su suspensión guiada por la negativización microbiológica; y el empleo de técnicas combinadas de autoplastia y prótesis apoyadas en la terapia de presión negativa en la restauración de la pared abdominal, con lo que se ha obtenido un buen resultado. Read More

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http://dx.doi.org/10.24875/CIRU.18000352DOI Listing
January 2018
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Pyoderma Gangrenosum Misdiagnosis Resulting in Amputation: A Review.

J Trauma Acute Care Surg 2018 Oct 23. Epub 2018 Oct 23.

Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.

Pyoderma Gangrenosum (PG) is a rare, ulcerative cutaneous disorder typically affecting the lower extremities. The clinical appearance of PG can mimic various cutaneous infections and neoplasms, leading to misdiagnosis and mistreatment including unnecessary surgical interventions such as debridements and even amputations. Diagnostic criteria exist, including characteristic clinical appearance and the exclusion of other diagnoses, however no definitive test exists to confirm the diagnosis of PG. Read More

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http://Insights.ovid.com/crossref?an=01586154-900000000-9852
Publisher Site
http://dx.doi.org/10.1097/TA.0000000000002096DOI Listing
October 2018
14 Reads

Sepsis and Pleural Empyema Caused by after Influenza A Virus Infection.

Case Rep Pediatr 2018 23;2018:4509847. Epub 2018 Sep 23.

Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Toon, Japan.

(also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. Read More

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http://dx.doi.org/10.1155/2018/4509847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174774PMC
September 2018
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Significance of Hyperbaric Oxygenation in the Treatment of Fournier's Gangrene: A Comparative Study.

Urol Int 2018 16;101(4):467-471. Epub 2018 Oct 16.

Department of Urology and Kidney Transplantation, Martin Luther University, Halle, Germany.

Introduction: Hyperbaric oxygenation (HBO), in addition to anti-infective and surgical therapy, seems to be a key treatment point for Fournier's gangrene. The aim of this study was to investigate the influence of HBO therapy on the outcome and prognosis of Fournier's gangrene.

Patients And Methods: In the present multicenter, retrospective observational study, we evaluated the data of approximately 62 patients diagnosed with Fournier's gangrene between 2007 and 2017. Read More

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http://dx.doi.org/10.1159/000493898DOI Listing
October 2018
2 Reads