Search Our Scientific Publications & Authors

Biomed Res Int 2018 13;2018:5042707. Epub 2018 Nov 13.

EKO Children's Hospital, Oberhausen, Witten/Herdecke University, Germany.

The importance for mortality and morbidity of an in-house pediatric surgery unit for premature infants with necrotizing enterocolitis (NEC) remains undefined. Data on 389 consecutive very low birth weight infants with a birth weight <1250 g admitted between 2009 and 2014 was retrospectively analyzed in two almost identical neonatal intensive care units. Epidemiological data (n=172 and n=217, respectively) were comparable. Read More

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

J Cardiol Cases 2013 Nov 26;8(5):145-147. Epub 2013 Sep 26.

Kokura Memorial Hospital, Kokura, Japan.

A 73-year-old man underwent sirolimus-eluting stent (SES) implantation for chest pain on exertion with left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX). The patient died due to non-obstructive mesenteric ischemia after 57 months of SES implantation. An autopsy demonstrated that the lesions of stented site at LAD and LCX were histopathologicaly similar images. Read More

J Cardiol Cases 2015 Feb 11;11(2):52-55. Epub 2014 Nov 11.

Department of Cardiology, Laiko General Hospital, Athens, Greece.

Churg-Strauss syndrome is a necrotizing vasculitis of small vessels characterized by upper and lower airway disease followed by peripheral eosinophilia and multiple organ involvement. Herein we present the case of a 45-year-old female patient with Churg-Strauss syndrome and myopericardial disease who improved upon cyclophosphamide treatment. Apart from discussing the characteristics of myopericardial disease in eosinophilic syndromes, we highlight the crucial role of cardiac imaging in the prompt recognition and management of such patients. Read More

J Cardiol Cases 2011 Apr 20;3(2):e71-e74. Epub 2011 Feb 20.

Department of Cardiology, Royal Blackburn Hospital, Haslingden Road, Blackburn BB2 3HH, United Kingdom.

Wegener's granulomatosis is a systemic necrotizing granulomatous vasculitis of small- to medium-sized vessels typically affecting upper and lower airways, lungs, and kidneys. Cardiac involvement is less common and conducting tissue involvement is extremely rare. Cardiac manifestations are often not clinically apparent, but are associated with increased mortality. Read More

Med Klin Intensivmed Notfmed 2018 Dec 10. Epub 2018 Dec 10.

Klinik für Gastroenterologie, Endokrinologie, Diabetologie und Allgemeine Innere Medizin, Klinikum Kassel, Kassel, Deutschland.

Acute necrotizing esophagitis ("black esophagus") is defined as complete necrosis of the esophageal mucosa, which typically affects the entire circumference. We report a case of a healthy 62-year-old woman, who became hemodynamically unstable due to stress cardiomyopathy with acute right heart failure. Transfusion-dependent anemia occurred 24 h later and an upper gastrointestinal endoscopy revealed a black discoloured mucosa of the distal esophagus. Read More

Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

Clinical Microbiology, University Hospital Basel, Basel, Switzerland.

This cohort study describes mortality predictors of necrotizing fasciitis (NF). Higher age, chronic kidney disease and higher Charlson score increased mortality rate. Mortality was more than three times higher in monomicrobial gram-negative NF than in type I or type II NF. Read More

Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1927. Epub 2018 Oct 2.

Section of Plastic Surgery, Department of Surgery, University of Calgary, Calgary, Alberta.

Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Read More

Int J Prev Med 2018 5;9:97. Epub 2018 Nov 5.

Department of Pediatrics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Germinal matrix-intraventricular hemorrhage (IVH) is the most common brain hemorrhage in preterm neonates. The importance of this hemorrhage lies in its severe complications. There is no definite treatment for IVH in neonates; therefore, the prevention of IVH should be considered. Read More

Rinsho Ketsueki 2018 ;59(11):2432-2437

Department of Pathology, Hakodate Municipal Hospital.

We report a case of a 60-year-old male who presented with fever and anasarca as well as hepatosplenomegaly, general lymphadenopathy, and disseminated intravascular coagulation (DIC), and was, therefore, admitted to our hospital. In addition, the patient suffered from respiratory failure and renal dysfunction and had pleural effusion and ascites. The pathological diagnosis from lymph node biopsy suggested multicentric Castleman's disease of the plasma cell type; however, the presence of high IL-6 levels, myelofibrosis, thrombocytopenia, anasarca, renal dysfunction, and hepatosplenomegaly led to a definitive diagnosis of TAFRO syndrome. Read More

J Pediatr 2018 Oct 24. Epub 2018 Oct 24.

Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Objective: To discover specific circulating microRNA (miRNA) biomarkers for the early differentiation of necrotizing enterocolitis (NEC) from neonatal sepsis and inflammatory conditions.

Study Design: The study comprised 3 distinct phases: differential microarray analysis to compare plasma miRNA expression profiles of NEC vs sepsis and non-NEC/nonsepsis cases, a case-control study to quantify dysregulated miRNAs as potential specific biomarkers of NEC, and a prospective cohort study to assess the diagnostic usefulness of the best miRNA biomarker(s).

Results: A distinct miRNA expression profile was observed in the NEC compared with the sepsis and non-NEC/nonsepsis groups. Read More

J Pediatr 2018 Dec 7. Epub 2018 Dec 7.

Department of Pediatrics, Uniformed Services University, Bethesda, MD.

Objective: To evaluate the impact of prematurity on fracture by age 5, controlling for medications and comorbidities of prematurity.

Study Design: We performed a retrospective cohort study of infants born in Military Treatment Facilities in 2009-2010 with ≥5 years of follow-up care. Gestational age, low birth weight, comorbidities of prematurity (osteopenia, necrotizing enterocolitis, chronic lung disease, and cholestasis) and fractures were identified by International Classification of Disease, 9th Edition, codes. Read More

Transfus Apher Sci 2018 Nov 16. Epub 2018 Nov 16.

Department of Transfusion Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh-160012, India.

Objective: We are reporting a case of acquired B phenomenon in a 14 days old pre-term baby presenting with necrotizing enterocolitis (NEC) where it was detected as an ABO discrepancy.

Method: The forward and reverse grouping was done using tube technique as well as column agglutination technique (ABD card and LISS Coombs AHG gel cards, Biorad, Switzerland). The direct antiglobulin test (DAT) was also done on gel card. Read More

J Surg Res 2019 Feb 23;234:294-302. Epub 2018 Oct 23.

Department of Surgery, Section of Pediatric Surgery, Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana; Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in experimental NEC, likely through protection against injury secondary to ischemia. We hypothesized that administration of GYY4137 would improve mesenteric perfusion, reduce intestinal injury, and reduce inflammatory responses in experimental NEC and ischemia-reperfusion injury, and that these benefits would be mediated through endothelial nitric oxide synthase-dependent pathways. Read More

Pregnancy Hypertens 2018 Oct 9;14:68-71. Epub 2018 Aug 9.

Division of Neonatology, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To identify the effect of pregnancy induced hypertension on neonatal outcomes in early and moderate preterm infants of gestational age less than 34 weeks.

Study Design: Prospectively collected data in 773 premature deliveries less than 34 weeks from 10 centers in China between July 2014 and July 2016 were analyzed in this cohort study. Univariate and Multivariate regression analyses were conducted to exam the effect of pregnancy induced hypertension on neonatal outcomes, including mortality to discharge, intrauterine growth restriction, severe brain injury, neonatal respiratory distress syndrome, bronchopulmonary dysplasia, necrotizing enterocolitis, early onset of sepsis and retinopathy of prematurity. Read More

Best Pract Res Clin Rheumatol 2018 02 17;32(1):83-93. Epub 2018 Nov 17.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

ANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Read More

Cleve Clin J Med 2018 Dec;85(12):912-913

Department of General Medicine, Chiba University Hospital, Chiba, Japan.

Acta Med Port 2018 Nov 30;31(11):648-655. Epub 2018 Nov 30.

Serviço de Neonatologia. Departamento de Pediatria. Hospital Universitário de Santa Maria. Centro Hospitalar Lisboa Norte. Lisboa. Clínica Universitária de Pediatria. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants.

Material And Methods: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years. Read More

Rheumatol Int 2018 Dec 5. Epub 2018 Dec 5.

Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.

Recent studies have shown a high prevalence of dyslipidemia in patients with systemic autoimmune myopathies (SAM). However, little is known about the safety of the use of statins in these patients, and this gap in research motivated the accomplishment of the present study. In a retrospective cohort study conducted from 2004 to 2018, 250 patients with SAM were evaluated, and 24 patients had stable forms of SAM (16 dermatomyositis, 1 polymyositis and 7 antisynthetase syndrome) but had dyslipidemia and had received statins. Read More

Stand Genomic Sci 2018 29;13:35. Epub 2018 Nov 29.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708 USA.

is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of , which were obtained from dried spices from the USA, the Middle East, China, and the Republic of Korea. The average genome size of the genomes was 4393 kb, with an average of 4055 protein coding genes, and an average genome G + C content of 56. Read More

Am J Perinatol 2018 Dec 3. Epub 2018 Dec 3.

Maternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Objective:  To determine if increasing predicted risk of cesarean was associated with longer labor length and increased morbidity among women undergoing induction with an unfavorable cervix.

Study Design:  Using a publically available database, we evaluated whether a previously validated prediction model for cesarean delivery after induction was associated with labor length, maternal morbidity (third-/fourth-degree lacerations, endometritis, blood transfusion, wound infection, venous thromboembolism, hysterectomy, intensive care unit admission, and death), and neonatal morbidity (blood transfusion, encephalopathy, intraventricular hemorrhage, severe respiratory distress syndrome, necrotizing enterocolitis, and sepsis). Full-term (≥37 weeks) singleton gestations with intact membranes and an unfavorable cervix (Bishop score ≤6 and dilation ≤2 cm) undergoing induction of labor were included. Read More

Microsurgery 2018 Dec 3. Epub 2018 Dec 3.

Department of Plastic, Reconstructive, Aesthetic Surgery and Burns, CHRU Rangueil, Toulouse, France.

Background: Extensive full thickness abdominopelvic defects pose a difficult challenge to surgeons. Autologous tissues are versatile and can provide a satisfying reconstructive option for this type of defects. The tensor fascia latae (TFL) and superficial circumflex iliac perforator (SCIP) flaps provide a large area of vascularized tissue and their use in reconstructive surgery is well-known. Read More

J Wildl Dis 2018 Dec 3. Epub 2018 Dec 3.

7 Dirección General de Medio Ambiente, Junta de Extremadura, Avda. de Luis Ramallo s/n, 06800 Mérida (Badajoz), Spain.

A free-ranging Iberian lynx ( Lynx pardinus) was found dead after 16 mo of being reintroduced. On gross necropsy, necrotic areas in the left biceps femoris and intercostal muscles were identified. Streptococcus canis was isolated from both groups of muscles and was confirmed by PCR, corroborating a necrotizing myositis diagnostic. Read More

Pediatr Pulmonol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.

Front Pediatr 2018 16;6:347. Epub 2018 Nov 16.

Paediatric Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

In 2014 probiotic supplementation ( and subspecies Infloran) was introduced as standard of care to prevent necrotizing enterocolitis (NEC) in extremely preterm infants in Norway. We aimed to evaluate the influence of probiotics and antibiotic therapy on the developing gut microbiota and antibiotic resistome in extremely preterm infants, and to compare with very preterm infants and term infants not given probiotics. A prospective, observational multicenter study in six tertiary-care neonatal units. Read More

Ann Surg Treat Res 2018 Dec 26;95(6):324-332. Epub 2018 Nov 26.

Department of Plastic and Reconstructive Surgery, Ajou University School of Medicine, Suwon, Korea.

Purpose: We present our experience involving the management of this disease, identifying prognostic factors affecting treatment outcomes.

Methods: The patients treated for Fournier gangrene at our institution were retrospectively reviewed. Data collected included demographics, extent of soft tissue necrosis, predisposing factors, etiological factors, laboratory values, and treatment outcomes. Read More

Reumatologia 2018 31;56(5):285-288. Epub 2018 Oct 31.

Department of Internal Medicine, Rheumatology and Clinical Immunology, Medical University of Silesia in Katowice, Poland.

Objectives: Inflammation has been revealed to be associated with angiogenesis. Granulomatosis with polyangiitis (GPA) and immune complex small vessel vasculitis (ICSVV) are forms of systemic vasculitides of different pathogenesis. GPA is a necrotizing granulomatosis and ICSVV is associated with inflammation of postcapillary venules induced by deposits of immune complexes. Read More

Infect Genet Evol 2018 Nov 28;68:1-9. Epub 2018 Nov 28.

Université Laval, Quebec City, QC, Canada. Electronic address:

The bacterium Aeromonas salmonicida is known since long time as a major fish pathogen unable to grow at 37 °C. However, some cases of human infection by putative mesophilic A. salmonicida have been reported. Read More

Pediatr Neurol 2018 Oct 3;87:30-35. Epub 2018 Aug 3.

Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Baltimore, Maryland. Electronic address:

Background: Hormonal therapy is the treatment of choice in most patients with infantile spasms, but the optimal way to provide this therapy is unclear. Intramuscular adrenocorticotropic hormone (ACTH) has historically used first-line; however, there are significant logistical and financial issues. Our institution has used high-dose prednisolone as the first-line hormonal treatment of infantile spasms since 2006 and published our early experience with 15 infants in 2009. Read More

Blood Purif 2018 Dec 5:1-6. Epub 2018 Dec 5.

Renal failure patients have an increased risk of infection, including skin and soft tissue infections. This increased susceptibility is multifactorial, due to the conditions causing the renal failure as well as complications of treatment and renal failure's innate effects on patient health. These infections have a significant impact on patient morbidity, increased hospital and procedural demands, and the cost of health care. Read More

Braz J Med Biol Res 2018 Dec 3;52(1):e7581. Epub 2018 Dec 3.

Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Read More

PLoS One 2018 5;13(12):e0207298. Epub 2018 Dec 5.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United states of America.

We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131). Newborns (n = 372) were followed until death or discharge. Read More

Viruses 2018 Nov 30;10(12). Epub 2018 Nov 30.

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.

Rift Valley fever phlebovirus (RVFV), the causative agent of an emerging zoonotic disease in Africa and Arabia, can infect a variety of species, predominantly ruminants, camelids, and humans. While clinical symptoms are mostly absent in adult ruminants and camelids, RVFV infection may lead to a serious, sometimes fatal disease in humans. Virus transmissions between individuals and between species mainly occur through mosquito bites, but direct or even indirect contact with infectious materials may also result in infection. Read More

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Service d'Odontologie du CHU, 549 avenue du Pr JL Viala, 34295 Montpellier cedex 5, France. Electronic address:

Plasminogen deficiency is a rare congenital condition that leads to pseudomembraneous lesions, such as ligneous conjunctivitis and ligneous gingivitis. Because of its rarity, ligneous gingivitis is not a pathology one may easily suspect from its clinical symptoms. We report the case of a 35-year-old Caucasian woman who experienced gum masses with white spots, but no pain. Read More

Turk J Pediatr 2018 ;60(3):326-330

Division of Pediatric Nephrology, Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey.

Gökçe İ, Altuntaş Ü, Filinte D, Alpay H. Polyarteritis nodosa in case of familial Mediterranean fever. Turk J Pediatr 2018; 60: 326-330. Read More

Case Rep Surg 2018 28;2018:8260968. Epub 2018 Oct 28.

Department of Surgery, Kensei Hospital, Hirosaki-shi, Aomori, Japan.

Streptococcal toxic shock syndrome (STSS) is a life-threatening disease caused by infection of . Here, we report an uncommon case of STSS with both diffuse peritonitis and necrotizing fasciitis and summarize previous cases. The patient was diagnosed with STSS due to an infection of the soft tissue of the lower extremity after surgery for diffuse peritonitis. Read More

Gastroenterol Res Pract 2018 30;2018:2795468. Epub 2018 Oct 30.

Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China.

Background: Enteral feeds are an essential part of care for infants and may be a potential risk factor in NEC development. The present study objective was to evaluate the relationship between nil per os (NPO) and clinical outcomes in infants with NEC.

Methods: This was a retrospective review of 196 premature, low-birth-weight infants with NEC from January 1, 2011, to October 31, 2016, at four academic tertiary care hospitals. Read More

Iran J Med Sci 2018 Nov;43(6):653-658

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Lagos State University College of Medicine, Lagos State, Nigeria.

Necrotizing fasciitis of the head and neck is a rare but rapidly progressive infection involving the skin, subcutaneous tissue, and fascia. We report 4 cases of cervicofacial necrotizing fasciitis with similar patterns of presentation. All the 4 cases presented with an odontogenic source and no underlying medical condition. Read More

Respir Med 2018 Dec 10;145:182-191. Epub 2018 Nov 10.

University of Texas Southwestern Medical Center, Department of Pulmonary and Critical Care Medicine, United States.

The hallmark of vasculitis is autoimmune inflammation of blood vessels and surrounding tissues, resulting in an array of constitutional symptoms and organ damage. The lung is commonly targeted in the more familiar ANCA-associated small vessel vasculitidies, but large and medium vessel vasculitides, including Takayasu arteritis, giant cell arteritis, polyarteritis nodosa, Behcet's disease, and necrotizing sarcoid granulomatosis, may also feature prominent pulmonary involvement. Pulmonary manifestations of these conditions include pulmonary arterial aneurysms, pulmonary hypertension, diffuse alveolar hemorrhage, pulmonary nodules, and parenchymal infiltrates. Read More

Int J Surg 2018 Nov 27;61:17-25. Epub 2018 Nov 27.

Department of Pediatric, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050000, China. Electronic address:

Aim: A systematic review and meta-analysis was designed to evaluate the efficacy and safety of Bifidobacterium for preventing necrotizing enterocolitis (NEC) in preterm infants.

Methods: We searched the Cochrane Library, PubMed, EMBASE and Web of Science to December 2017. Risk ratio (RR) with 95% confidence intervals (CIs) were estimated to compare the outcomes of the groups. Read More

Curr Pediatr Rev 2018 Nov 29. Epub 2018 Nov 29.

University of Florence, Meyer Children's Hospital, Florence. Italy.

Management of severe Short Bowel Syndrome (SBS) is still one of the largest challenges of the medicine. Vast majority of the short bowel patients are children, the conditions that lead to this possible outcome most often are necrotizing enterocolitis (NEC), small intestinal volvulus as a result of intestinal malrotation, gastroschisis and the "apple peel" syndrome. Therefore paediatricians and paediatric surgeons face this challenge most often. Read More

Curr Pediatr Rev 2018 Nov 30. Epub 2018 Nov 30.

Pediatric surgery Unit - INFERMI Hospital- Rimini. Italy.

Necrotizing enterocolitis (NEC) is a significant complication for premature newborns. Infants who survive NEC are at increased risk of having poor long-term physiological and neurodevelopmental growth. The objective of this paper is to give a comprehensive description of the long-term consequences of NEC. Read More

BMC Pulm Med 2018 Nov 29;18(1):181. Epub 2018 Nov 29.

Department of Pulmonary, Critical Care, Hyperbaric and Sleep Medicine, Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA, 92354, USA.

Background: Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophilic granulomatosis with polyangiitis (EGPA) is also a systemic ANCA-associated vasculitis, but EGPA is characterized by eosinophilic as well as granulomatous inflammation and is more commonly associated with asthma and eosinophilia. Polyangiitis overlap syndrome is defined as systemic vasculitis that does not fit precisely into a single category of classical vasculitis classification and/or overlaps with more than one category. Read More

Phys Ther 2018 Nov 28. Epub 2018 Nov 28.

Philadelphia College of Osteopathic Medicine, 625 Old Peachtree Rd NW, Suwanee, GA 30024 (USA).

Background: High-level lower extremity amputation (HLLEA) has significant impact on an individual's ability to ambulate and maintain cardiovascular fitness for extended periods of time.

Objective: The purpose of this study was to evaluate whether body weight support (BWS) would improve energy efficiency in an individual with HLLEA in order to achieve appropriate target cardiovascular intensity for aerobic training.

Design: This is an exploratory single-subject study. Read More

PLoS One 2018 29;13(11):e0207730. Epub 2018 Nov 29.

Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University, Chuo-ku, Tokyo, Japan.

Background: Vitamin A (VA) supplementation reduces the risk of developing bronchopulmonary dysplasia (BPD). However, a previous meta-analysis showed that VA had minimal efficacy for preventing BPD in very low birth weight infants (VLBWIs).

Aims: To elucidate the effects of VA supplementation for BPD prevention in extremely low birth weight infants (ELBWIs). Read More

Pediatr Infect Dis J 2018 Nov 27. Epub 2018 Nov 27.

Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care & Neuropediatrics, Medical University of Vienna, Vienna, Austria.

Background: The Gram-negative bacterium Klebsiella pneumoniae is a frequent pathogen causing outbreaks in neonatal intensive care units (NICUs). Some Enterobacteriaceae can acquire the ability to sequester iron from infected tissue by secretion of iron-chelating compounds such as yersiniabactin. Here we describe an outbreak and clinical management of infections due to a highly virulent yersiniabactin-producing, non-multiresistant Klebsiella pneumoniae strain in a NICU. Read More

Int J Gynaecol Obstet 2018 Nov 29. Epub 2018 Nov 29.

Transbaikal Regional Hospital, Chita, Russia.

This report presents the relapse and treatment of streptococcal infection in the postpartum period in a patient with severe group A streptococcal sepsis. Maternal sepsis was estimated to cause around 10.7% of maternal deaths worldwide between 2003 and 2009 [1]. Read More

Muscle Nerve 2018 Nov 29. Epub 2018 Nov 29.

Concord Hospital, Sydney, Australia.

Front Microbiol 2018 14;9:2755. Epub 2018 Nov 14.

Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States.

Intestinal barrier immaturity, or "leaky gut," is the proximate cause of susceptibility to necrotizing enterocolitis in preterm neonates. However, the impact of intestinal microbiota development on intestinal mucosal barrier maturation has not been evaluated in this population. In this study, we investigated a longitudinally sampled cohort of 38 preterm infants < 33 weeks gestation monitored for intestinal permeability (IP) and fecal microbiota during the first 2 weeks of life. Read More

J Matern Fetal Neonatal Med 2018 Nov 28:1-171. Epub 2018 Nov 28.

a Christian Medical College and Hospital Vellore , Vellore , India.

Objective: To optimize growth in very low birth weight (VLBW) infants, human milk fortification is standard of care in neonatal units of high income countries. However, commercial fortifiers may not be available or it may be too expensive in resource limited settings. As an alternative to using human milk fortifiers, we studied the effects of milk fortification with an infant formula on growth and biochemical parameters of very low birth weight (VLBW) infants Methods: We undertook a prospective, randomized controlled trial in the neonatal unit of a tertiary care hospital in south India. Read More