2,174 results match your criteria Necrobiosis Lipoidica
Vet World 2018 Nov 22;11(10):1473-1478. Epub 2018 Oct 22.
Department of Agrobiotechnology, Agrarian Technological Institute, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Aim: The purpose of this work was to study the dynamics of structural manifestations of acute cases of postpartum endometritis in cows.
Materials And Methods: The light and electron microscopy methods were used when studying structural changes in the endometrium in case of postpartum endometritis in seven cows. Sections of endometrial specimens for light microscopy, 5-7 µm thick, were stained with hematoxylin and eosin and also by Van Gieson's. Read More
Pediatr Dermatol 2018 Dec 2. Epub 2018 Dec 2.
Dermatology Department, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.
Necrobiosis lipoidica (NL) is a rare chronic granulomatous inflammatory skin disease characterized by brownish-red papules and yellowish plaques with atrophic centers, which usually affect the legs, bilaterally. The average age of onset is 30-40 years, and there are very few reported cases of necrobiosis lipoidica in children. A nondiabetic girl aged 14 years presented to our clinic with a history of an asymptomatic, 7 × 5-cm single red plaque over her back in the interscapular area, which had started 5 years ago. Read More
Clin Exp Dermatol 2018 Dec 1. Epub 2018 Dec 1.
Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA.
Dermatol Clin 2019 Jan;37(1):49-64
Dermatology Administration, Perelman Center for Advanced Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, 7th Floor, South Tower, Philadelphia, PA 19104, USA. Electronic address:
Inflammatory granulomatous dermatitides include cutaneous sarcoidosis, necrobiosis lipoidica, granuloma annulare, and reactive granulomatous dermatitis. The etiopathogenesis of these disorders is not well understood; but the T helper 1 response mediated by interferon-gamma, tumor necrosis factor-alpha, and interleukin (IL) 1, 2, and 6 and the T helper 17 response mediated by IL-17 play a role. These inflammatory granulomatous disorders often have cutaneous manifestations in addition to extracutaneous manifestations or associations with systemic diseases. Read More
Dermatology 2018 Nov 21:1-7. Epub 2018 Nov 21.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More
Indian J Hematol Blood Transfus 2018 Oct 12;34(4):643-647. Epub 2018 Jan 12.
Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006 India.
Myelonecrosisis a rare antemortem finding most commonly seen in haematopoeitic neoplasms, especially in acute leukemia. When myelonecrosis occurs at the time of presentation, it imposes certain diagnostic issues in sub categorization of leukemias which is necessary for therapeutic as well as prognostic purposes. Flow cytometry, though is a powerful modality, has its own limitations especially when the cells are not fresh and viable; and when the specimen is not of adequate cellularity which is usual in cases of myelonecrosis. Read More
Trop Doct 2018 Oct 4:49475518803191. Epub 2018 Oct 4.
4 Associate Professor, Department of Pathology, Kasturba Medical College, Manipal, India.
Granuloma multiforme (GM) is a chronic granulomatous skin condition which is clinically characterised by annular lesions mainly over sun-exposed areas and histologically by focal necrobiosis and histiocytic granulomas. Its significance lies in the fact that it can clinically resemble tuberculoid leprosy and hence it can be missed. Here, we report a case of GM from India in a 55-year-old female agriculturist, with multiple asymptomatic large annular rings of papules over the photo-distributed areas. Read More
Clin Exp Dermatol 2018 Oct 2. Epub 2018 Oct 2.
Department of Dermatology, University Hospital Coventry and Warwickshire, Coventry, UK.
JAAD Case Rep 2018 Sep 14;4(8):802-804. Epub 2018 Sep 14.
Department of Dermatology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
J Cutan Pathol 2018 Dec 9;45(12):944-948. Epub 2018 Oct 9.
Department of Dermatology, University of Virginia, Charlottesville, Virginia.
We report the case of a 40-year-old African-American female with biopsy-proven pulmonary sarcoidosis who developed atrophic plaques on her shins, trunk, and scalp that were clinically and histologically consistent with necrobiosis lipoidica (NL). The lesions appeared 3 years after her diagnosis of sarcoidosis, and progressed despite chronic prednisone. Sarcoidosis and NL are granulomatous skin disorders reported to coexist in the same patient only 10 times in the literature. Read More
Dermatol Clin 2018 Oct 2;36(4):369-375. Epub 2018 Aug 2.
Department of Medical Area, Institute of Dermatology, University of Udine, Udine, Italy.
Although diagnosis of cutaneous granulomatous disorders (CGDs) is usually suspected based on morphologic findings, localization, and anamnestic data, clinical differentiation from each other and from similar dermatoses may be challenging. Recently, dermatoscopy has been demonstrated to be a useful tool for assisting the recognition of several CGDs. This article provides a current overview of the dermatoscopic features of the main noninfectious and infectious CGDs, including sarcoidosis, necrobiosis lipoidica, granuloma annulare, rheumatoid nodules, and leishmaniasis. Read More
Acta Med Port 2018 Aug 31;31(7-8):440. Epub 2018 Aug 31.
Department of Dermatology. Centro Hospitalar Lisboa Norte. Lisboa. Instituto de Medicina Molecular. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.
An Bras Dermatol 2018 Sep-Oct;93(5):740-742
Medical student, Dermatology League, Universidade Federal de Pelotas, Pelotas (RS), Brazil.
Light microscopy of granuloma annulare shows mucin deposition with lympho-histiocytic infiltrate. We describe the ultrastructural three-dimensional aspects of a typical case of granuloma with characteristic histopathological findings. At the ultrastructural level, affected collagen bundles and granular mucin deposition were observed. Read More
Pan Afr Med J 2018;29:214. Epub 2018 Apr 13.
Service of Endocrinology, Diabetology and Metabolic Diseases, University Hospital of Marrakech, Marrakech, Morocco.
BMJ Case Rep 2018 Aug 11;2018. Epub 2018 Aug 11.
Department of Dermatology, Stanford University, Stanford, California, USA.
The association of malignant lymphomas with non-necrotic epithelioid granulomas has been reported rarely since 1977. Hodgkin's disease-associated widespread cutaneous granuloma annulare (GA) has been reported in only eight patients. We report the second case of subcutaneous GA associated with Hodgkin's disease. Read More
Acta Dermatovenerol Croat 2017 Dec;25(4):298-299
Dario Didona, MD, Prima Divisione Dermatologica , Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Mont di Creta 104 , 00167 Rome, Italy;
Cutaneous sarcoidosis is not an uncommon disorder, and the skin can be the sole manifestation in about 10% of patients. However, when the involved anatomical area of the cutaneous sarcoidosis is the scalp and it presents as a scarring alopecia, there is an increased risk of a systemic disease (1,2). A 79-year-old Caucasian male patient presented to our Institute with annular and painless plaques of the scalp, with variable diameter, showing a reddish and yellowish color (Figure 1, a). Read More
Acta Dermatovenerol Croat 2017 Dec;25(4):292-294
Mihaela Paula Toader MD, PhD, T. Popa University of Medicine and Pharmacy, Iasi, Romania, 16 Universitatii str. 700115, Iasi, Romania;
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated. Read More
J Dtsch Dermatol Ges 2018 Jul;16(7):873-890
Department of Dermatology, Venereology and Allergology, University Medical Center Bochum, Bochum, Germany.
Successful management of patients with leg ulcers requires identification of the underlying etiology, with subsequent initiation of causal treatment, if feasible. Supplementary measures of first choice include stage-adjusted wound treatment, usually combined with compression therapy. The significance of systemic drugs has been the subject of controversial debate, depending on the underlying cause of the condition. Read More
Medicine (Baltimore) 2018 Jun;97(26):e11143
Rationale: IgG4-related disease (IgG4-RD) is an emerging immune-mediated disease characterized by multi-organ involvement and variable clinical behavior.
Patient Concerns: We describe the case of a 50-year-old woman affected by a rare variant of IgG4-RD, characterized by eyelid xanthelasmas, adult-onset asthma and salivary and lacrimal glands enlargement. Multiple lymphadenopathies and a pulmonary mass were present at initial evaluation. Read More
JAMA Dermatol 2018 Jun;154(6):733-734
Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Indian J Dermatol Venereol Leprol 2018 Jul-Aug;84(4):481-484
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Cosmet Laser Ther 2018 May 8:1-2. Epub 2018 May 8.
a Dermatology , Habib Thameur Hospital , Tunis , Tunisia.
Photodiagnosis Photodyn Ther 2018 Jun 4;22:223-226. Epub 2018 May 4.
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Denmark.
Introduction: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes.
Methods: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application. Read More
Am J Dermatopathol 2018 Oct;40(10):762-766
Department of Dermatology, University of Florida College of Medicine, Gainesville, FL.
Actinic granuloma (AG) manifests as annular plaques on sun-damaged skin. There remains no universal consensus on the nosology, etiology, or clinicopathologic criteria of AG as a distinct entity. Broadly, AG is characterized by granulomatous inflammation, multinucleated giant cells, elastophagocytosis, and the absence of mucin and necrobiosis. Read More
Case Rep Ophthalmol 2018 Jan-Apr;9(1):70-75. Epub 2018 Jan 17.
Department of Ophthalmology and Visual Neurosciences, University of Minnesota, Minneapolis, Minnesota, USA.
Background: Necrobiotic xanthogranuloma (NXG) is a rare non-Langerhans histiocytosis with cutaneous manifestations, most commonly of the periorbital skin, and is often associated with hematologic disorders such as monoclonal gammopathy. Treatment of NXG is notoriously difficult, and fraught with recurrence and progression.
Case Presentation: The authors describe a case of NXG with periorbital involvement in a patient with a complex autoimmune and hematologic medical history. Read More
Pediatr Dermatol 2018 May 24;35(3):e200-e201. Epub 2018 Mar 24.
Servicio de Dermatología, Hospital Universitario de Cabueñes, Gijón, Asturias, Spain.
Subcutaneous granuloma annulare is a benign inflammatory disorder that primarily affects healthy children and manifests as a rapidly growing, painless, nonmobile mass, most commonly located in the leg. The current case highlights the sonographic appearance of subcutaneous granuloma annulare. Ultrasound color Doppler is a helpful noninvasive imaging test that may allow physicians to confirm the diagnosis of subcutaneous granuloma annulare and avoid unnecessary medical procedures. Read More
Ann Hematol 2018 Aug 22;97(8):1471-1479. Epub 2018 Mar 22.
Division of Hematology/Oncology, Mayo Clinic, 5777 E. Mayo Boulevard, Phoenix, AZ, 85054, USA.
To characterize the clinical features, associated disorders, and treatment of necrobiotic xanthogranuloma (NXG), a rare non-Langerhans cell histiocytosis, we conducted a retrospective review of pathologically confirmed NXG at Mayo Clinic Arizona from 1987 to June 2017. Data on clinical findings, laboratory findings, associated disorders, therapy, and response to therapy were extracted. Nineteen patients were identified. Read More
Cutis 2018 Jan;101(1):12;15
Department of Dermatology, The University of Kansas, Kansas City, USA.
Bull Exp Biol Med 2018 Mar 5;164(4):508-513. Epub 2018 Mar 5.
Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia.
The study examined the myocardial ultrastructural alterations in rats maintained on various atherogenic diets. It revealed the complex ultrastructural alterations of cardiomyocytes and endotheliocytes (including the lytic and destructive changes of the intracellular organelles, upregulation of the autophagocytosis in the cardiomyocytes, and necrobiosis with apoptosis of endotheliocytes) reflecting the cytopathic features of circulating cholesterol and lipoproteins, whose elevation determined the intensity of destructive processes. The revealed peculiarities in the changes of lipid inclusions (their osmiophilic transformation) in cardiomyocytes can be provoked by entry of cholesterol into the cells and its further metabolic modifications. Read More
J Dermatolog Treat 2018 Nov 14;29(7):720-724. Epub 2018 Mar 14.
b UConn Health Department of Dermatology , Farmington , CT , USA.
Background: Management of generalized granuloma annulare (GGA) poses challenges for both patients and dermatologists. Currently, there are no established first-line therapies for GGA and the available therapeutic modalities are based on individual case reports and a few small case series. Further, there are limited publications assessing the efficacy of methotrexate in treating GGA. Read More
Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
Department of Dermatology, University of California Davis School of Medicine, Sacramento, California.
We present a 42-year-old woman with no history of diabetes or glucose intolerance who had a 5-year history of ulcerative necrobiosis lipoidica (NL). Despite failure of multiple medications, she experienced clearing of her ulcers after her treatment was changed to ustekinumab. We discuss our patient's disease course and elaborate upon mechanistic reasons for her improvement related to ustekinumab therapy. Read More
Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
Department of Dermatology, Centro Hospitalar do Porto, Portugal.
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease of undetermined cause, characterized by annular plaques with raised erythematous borders in sun-exposed skin. The typical histologic features are dermal infiltration by multinucleated giant cells, elastin degeneration, and elastophagocytosis. The authors describe a clinical case of AEGCG, which exhibited an excellent response to hydroxycloroquine. Read More
J Cosmet Laser Ther 2018 Feb 20:1-2. Epub 2018 Feb 20.
a Plastic Surgery Center of Pennsylvania , Erie , PA , USA.
A 57-year-old female was presented with an irrepressible case of Necrobiosis Lipoidica considering the possibility of a surgical skin graft. Instead, a pulsed dye laser treatment was used as an alternate treatment. Previous case studies have been found in the literature on the effect of pulsed dye laser on Necrobiosis Lipoidica. Read More
Postepy Dermatol Alergol 2017 Dec 31;34(6):618-621. Epub 2017 Dec 31.
Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
J Dermatol 2018 Jul 6;45(7):e193-e194. Epub 2018 Feb 6.
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146
Clinique de Dermatologie, Hôpitaux Universitaires de Genève, Rue Gabrielle Perret-Gentil 4, CH-1211, Genève, Switzerland.
Cutaneous granulomatosis is a heterogeneous group of diseases, characterized by a skin inflammatory reaction triggered by a wide variety of stimuli, including infections, foreign bodies, malignancy, metabolites, and chemicals. From a pathogenic point of view, they are divided into non-infectious and infectious granulomas. Pathophysiological mechanisms are still poorly understood. Read More
Clin Exp Dermatol 2018 Mar 10;43(2):219-221. Epub 2018 Jan 10.
Department of Medical Sciences - Unit of Dermatology, University of Cagliari, Cagliari, Italy.
Clin Exp Dermatol 2018 Mar 5;43(2):225-227. Epub 2018 Jan 5.
Department of Dermatology, Royal Marsden Hospital, London, UK.
An Bras Dermatol 2017 ;92(5 Suppl 1):82-84
Department of Dermatology of the Universidade de Santo Amaro (UNISA) - Santo Amaro (SP), Brazil.
Granuloma annulare is a benign cutaneous inflammatory disease, whose lesions have spontaneous improvement in two years in 50% of cases, but there is recurrence in 40% of patients. Treatment may be topical, intralesional or systemic. The use of phototherapy with narrowband UVB is highlighted, whose mechanism of action in this disease is still unclear, probably related to the inhibition of T lymphocytes. Read More
Sud Med Ekspert 2017;60(6):9-12
Department of Pathological Anatomy with the course of forensic medicine, Saint-Petersburg State Pediatric Medical University, Ministry of Health of the Russia, Saint-Petersburg, Russia, 194100; Department of Forensic Medicine and Jurisprudence Science, I.P. Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg, Russia, 197022.
This article presents the results of the retrospective analysis of the protocols of forensic medical autopsies and histological studies of the cerebral tissues together with the data obtained by their statistical treatment. The objective of present work was to study and evaluate the structural changes in the cerebral tissues associated with sudden cardiac death from alcoholic cardiomyopathy. It was shown that the morphological changes in the endothelial lining of the microcirculatory bed of the cerebral tissue can be a consequence of both the direct cytotoxic action of ethanol or its metabolites and the influence of cellular modulators liberation of which results in enhanced vascular permeability associated with trophic disturbances in the tissue. Read More
Clin Dermatol 2018 Jan - Feb;36(1):94-100. Epub 2017 Sep 8.
Department of Dermatology, Istanbul Medeniyet University, Medical School, Istanbul, Turkey. Electronic address:
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS. Read More
Am J Clin Dermatol 2018 Jun;19(3):333-344
Dermatology Service, Veterans Affairs Medical Center, 800 Poly Place, Brooklyn, 11209, NY, USA.
Granuloma annulare (GA) is a benign inflammatory disease associated with many conditions such as malignancy, trauma, thyroid disease, diabetes mellitus, and HIV infection. Common clinical subtypes include localized GA, generalized GA, subcutaneous GA, perforating GA, and patch GA. There exists an abundance of literature on GA, yet we know relatively little about its exact etiology and even less about its treatment. Read More
Ann Dermatol Venereol 2018 Feb 6;145(2):116-119. Epub 2017 Dec 6.
EA3181, service de dermatologie, université de Bourgogne-Franche-Comté, CHU, 3, boulevard Fleming, 25030 Besançon, France.
Background: Granuloma annulare as a granulomatous cutaneous reaction may be drug-induced. Immune checkpoint inhibitors including programmed death-1 (PD-1) inhibitors show remarkable antitumor activity and are approved for melanoma and other cancers. Different immune-related adverse effects have been described. Read More
Pediatr Dermatol 2018 Jan 4;35(1):e72-e73. Epub 2017 Dec 4.
Department of Dermatology, Boston Children's Hospital, Boston, MA, USA.
Subcutaneous granuloma annulare (SGA) is an uncommon subtype of granuloma annulare. There are few reports of this entity solely affecting the scalp. We report a case of biopsy-proven SGA in a 21-month-old boy with six asymptomatic, rock-hard scalp nodules. Read More
Clin Dermatol 2017 Nov - Dec;35(6):555-565. Epub 2017 Aug 4.
Department of Dermatology, University of Connecticut Health Center, Farmington, CT.
Granulomatous diseases represent a heterogeneous group of conditions characterized by histiocytic inflammation that affect patients of any age. These diseases differ widely in their pathogenesis and include infectious and noninfectious conditions. This review focuses on noninfectious granulomatous conditions, with particular emphasis on age-related differences in the onset, epidemiology, clinical manifestations, prognosis, and age-specific management of specific granulomatous disorders. Read More
An Bras Dermatol 2017 May-Jun;92(3):438-439
Department of Dermatology, Medical School, Universidade de Santo Amaro (UNISA), São Paulo, SP, Brazil.
An Bras Dermatol 2017 May-Jun;92(3):419-420
Dermatology Clinic, Santa Casa de Misericórdia de Belo Horizonte - Belo Horizonte, MG, Brazil.
A 59-year-old woman reported a 20-day history of slightly scaly erythematous infiltrated patches on her palms and soles with a histopathological result which was consistent with interstitial-pattern granuloma annulare, clinically classified as patch granuloma annulare. This is a rare clinical variant of granuloma annulare, with an unknown incidence and characteristic clinical and histopathological features. The patient evolved with a complete remission of the lesions after biopsy and the use of high-potency topical corticosteroid. Read More
Transl Pediatr 2017 Oct;6(4):300-312
The Ohio State University College of Medicine, Columbus, OH, USA.
The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More
Am J Dermatopathol 2018 May;40(5):383-385
Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada.
A healthy 50-year-old woman had a tattoo performed on the posterior aspect of her neck and another on the dorsum of her left foot. Several weeks later, she noted redness, tenderness, and intense pruritis at both tattoo sites. Treatment with cephalexin and hydrocortisone cream was instituted, without success. Read More