814 results match your criteria Neck Dissection Classification

Adjuvant Treatment of the Salivary Duct Carcinoma with Her2 Overexpression.

Case Rep Oncol 2021 Jan-Apr;14(1):610-615. Epub 2021 Mar 29.

Pathology Clinic, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.

Malignant salivary gland tumors form 11% of all head and neck tumors. Salivary duct carcinoma (SDC) of the parotid gland is an uncommon and highly aggressive tumor accounting for 2% of all salivary gland malignancies. The fourth edition of the WHO Classification of Head and Neck Tumors reported global annual incidence of 0. Read More

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Nonfunctional parathyroid cancer a case report.

Rozhl Chir 2021 ;100(3):133-137

Introduction: Parathyroid cancer is a rare endocrine malignancy. These tumors are typically functional, causing severe hypercalcemia due to primary hyperparathyroidism. Nonfunctional parathyroid cancer with normal serum calcium and parathyroid hormone levels is extremely rare. Read More

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Headache characteristics and frequency of migraine in patients with cervical artery dissections.

Acta Neurol Belg 2021 Apr 23. Epub 2021 Apr 23.

Department of Neurology, Cerrahpasa School of Medicine, İstanbul University, Istanbul, Turkey.

Headache is a common symptom of cervical artery dissections (CAD). Sometimes, it can be the only symptom and mimic migraine. We aimed to investigate headache characteristics and previous history of migraine in CAD patients, and to compare headache features between patients with internal carotid artery dissection (ICAD) and vertebral artery dissection (VAD). Read More

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Neck Dissections Based on Sentinel Lymph Node Navigation Versus Elective Neck Dissections in Early Oral Cancers: A Randomized, Multicenter, and Noninferiority Trial.

J Clin Oncol 2021 Apr 20:JCO2003637. Epub 2021 Apr 20.

National Cancer Center Hospital, Tokyo, Japan.

Purpose: This study aimed to compare patients with early oral cavity squamous cell carcinoma (OCSCC) (tumor category [T] 1-2, node-negative, and no distant metastasis) treated with traditional elective neck dissection (ND) with those managed by sentinel lymph node biopsy (SLNB) using survival and neck function and complications as end points.

Methods: Sixteen institutions in Japan participated in the study (trial registration number: UMIN000006510). Patients of age ≥ 18 years with histologically confirmed, previously untreated OCSCC (Union for International Cancer Control TNM Classification of Malignant Tumors 7th edition T1-2, node-negative no distant metastasis), with ≥ 4 mm (T1) depth of invasion, were randomly assigned to undergo standard selective ND (ND group; n = 137) or SLNB-navigated ND (SLNB group; n = 134). Read More

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Metastatic hobnail variant of papillary thyroid carcinoma: A diagnostic challenge in cell block preparation.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):358-361

Department of Oncosurgery, IMS and SUM Hospital, Bhubaneswar, Odisha, India.

Hobnail variant of papillary thyroid carcinoma (HV-PTC) is an unusual entity recently included in WHO classification of endocrine tumors (2017) and proposed as an aggressive variant of PTC. Compared to patients of classical counterparts, HV-PTC frequently has extrathyroidal extension, exhibits nodal or distant metastasis, and responds poorly to radioiodine treatment, leading to increased mortality. We hereby describe the cytohistological and immunohistochemical features of a metastatic HV-PTC in 55-year-old male, previously diagnosed as poorly differentiated papillary thyroid carcinoma in thyroidectomy specimen. Read More

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Endoscopic Anatomy of the Chorda Tympani: Systematic Dissection, Novel Anatomic Classification, and Surgical Implications.

Otol Neurotol 2021 Mar 19. Epub 2021 Mar 19.

Department of Otolaryngology Head and Neck Surgery, Inselspital, University Hospital and University of Bern Department of Otolaryngology Head and Neck Surgery, University Hospital of Modena, University of Modena and Reggio Emilia, Italy Hearing Research Laboratory, ARTORG Center for Biomedical Engineering, University of Bern, Bern, Switzerland Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Hypothesis: A transcanal endoscopic approach enables visualization of the variable course of the chorda tympani inside the middle ear.

Background: The chorda tympani is the longest intrapetrous branch of the facial nerve. Despite having been investigated in several studies, a description of its tympanic tract from an endoscopic point of view is lacking in the literature. Read More

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Contralateral neck failure in oral tongue cancer: Outcomes from two centers using predefined treatment criteria.

Head Neck 2021 Mar 17. Epub 2021 Mar 17.

Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Background: The objective was to determine the incidence of, and factors associated with contralateral neck failure (CNF) in oral tongue squamous cell carcinoma (OTSCC).

Methods: Consecutive patients with OTSCC between 2007 and 2016 were included. The predefined policy of the contralateral neck included neck dissection (ND) where the primary tumor extended/crossed midline or the contralateral neck was involved; and elective nodal irradiation (ENI) where the primary tumor was ≤1 cm from midline/2 cm from tip. Read More

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Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer.

Medicina (Kaunas) 2021 Feb 21;57(2). Epub 2021 Feb 21.

Department of Pharmacology, Faculty of Medicine, University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia.

: Increased osteopontin (OPN) concentrations in the plasma of patients with head and neck squamous cancer (HNSCC) have diagnostic significance, and it can indicate more aggressive biological behavior of cancer. The aim of this study was to determine OPN levels in patients with HNSCC of different primary locations and to assess its prognostic significance in metastasis development. : This cohort study included 45 patients (41 male and 4 female patients) with HNSCC with different primary localization of head and neck. Read More

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February 2021

Anatomical-based classification for transoral base of tongue resection.

Head Neck 2021 May 13;43(5):1604-1609. Epub 2021 Feb 13.

Depatment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Background: To propose a classification of transoral base of tongue (BOT) procedures able to provide uniform terminology in order to better define postoperative results.

Methods: The classification resulted from the consensus of the different authors and is based on anatomical and surgical principles.

Results: The classification comprises three types of BOT resections: type 1 is the resection of the entire lingual tonsil to the muscular plane; type 2 is performed by removing the entire lingual tonsil and part of BOT muscles; type 3 is performed by removing the entire lingual tonsil and the entire BOT muscles. Read More

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Comprehensive analysis of prognostic value of lymph node staging classifications in patients with head and neck squamous cell carcinoma after cervical lymph node dissection.

Eur J Surg Oncol 2021 Jan 30. Epub 2021 Jan 30.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:

Purpose: To determine the optimal threshold of examined lymph node (ELN) number from cervical lymph node dissection for head and neck squamous cell carcinoma (HNSCC). Further to compare the prognostic value of multiple lymph node classification systems and to determine the most suitable scheme to predict survival.

Methods: A total of 20991 HNSCC patients were included. Read More

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January 2021

Contralateral lymph node recurrence rate and its prognostic factors in stage IVA-B well-lateralized oral cavity cancer.

Auris Nasus Larynx 2021 Jan 29. Epub 2021 Jan 29.

Department of radiation oncology, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City 81362, Taiwan; School of medicine, National Defense Medical Center, Taipei, Taiwan; Department of Nursing, Meiho University, Pingtung, Taiwan. Electronic address:

Purpose: To evaluate the contralateral lymph node recurrence rate (clLNRR) of stage IVA to IVB well-lateralized oral cavity cancer. To evaluate the risk factors of clLNRR.

Materials And Methods: Pathologic stage IVA-B squamous cell carcinoma of oral cavity, originating from buccal mucosa, gingiva, or retromolar trigone were retrospectively recruited. Read More

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January 2021

Superior Laryngeal Nerve Signal Attenuation Influences Voice Outcomes in Thyroid Surgery.

Laryngoscope 2021 06 31;131(6):1436-1442. Epub 2021 Jan 31.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: The objective was to identify whether injury of the external branch of the superior laryngeal nerve (EBSLN) or changes in EBSLN parameters after dissection during thyroidectomies correlate with changes in voice quality postoperatively.

Study Design: Prospective multicenter case series.

Methods: A prospective multicenter study was conducted on patients undergoing thyroidectomies with intraoperative nerve monitoring. Read More

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Redefining risk of contralateral cervical nodal disease in early stage oropharyngeal cancer in the human papillomavirus era.

Head Neck 2021 May 21;43(5):1409-1414. Epub 2021 Jan 21.

Department of Radiation Oncology, Mount Sinai Health System, New York, New York, USA.

Background: The optimal extent of surgery and/or radiation to the contralateral lymph node region is unknown in early-stage human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC).

Methods: To investigate the pathologic incidence of and risk factors for contralateral nodal disease (CND) in cT1-T2 HPV-related OPSCC treated with transoral robotic surgery (TORS) and bilateral neck dissection (BND), the records of 120 patients were reviewed.

Results: Eleven patients displayed pathologic contralateral nodal disease (pCND), including 7. Read More

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Additional Surgery for Occult Risk Factors After Lobectomy in Solitary Thyroid Nodules is Predicted by Cytopathology Classification and Tumor Size.

Endocr Pract 2020 Jul 24;26(7):754-760. Epub 2020 Nov 24.

Johns Hopkins University School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Baltimore, Maryland. Electronic address:

Objective: Clinical practice for differentiated thyroid cancer is moving towards lobectomy rather than total thyroidectomy in patients at low risk of recurrence. However, recurrence risk assessment depends on post-operative findings, while the surgical decision is based on preoperative factors. We determined the preoperative predictors of occult higher-risk pathology and rates of completion thyroidectomy among surgical candidates with nonbenign thyroid nodules 10 to 40 mm and no evidence of extrathyroidal extension or metastasis on preoperative evaluation. Read More

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Prognostic capacity of the weighted lymph node ratio in head and neck squamous cell carcinoma patients treated with salvage neck dissection.

Eur Arch Otorhinolaryngol 2021 Jan 16. Epub 2021 Jan 16.

Otorhinolaryngology and Head and Neck Surgery Department, Hospital de La Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, C/ Mas Casanovas, 90, 08041, Barcelona, Spain.

Purpose: The aim of the study was to assess the prognostic capacity of the recently described weighted lymph node ratio (WLNR) in patients with head and neck squamous cell carcinoma (HNSCC) who undergo salvage neck dissection for regional recurrence.

Material And Methods: We retrospectively studied 197 adult patients with head and neck squamous cell carcinoma treated with salvage neck dissection from 1990 to 2017.

Results: The mean value for the WLNR for all patients was 26. Read More

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January 2021

High rate of IIA/IIB neck groups involvement supports complete lateral neck dissection in thyroid carcinoma.

Gland Surg 2020 Dec;9(6):1973-1981

Department of Otolaryngology Head and Neck Surgery, Tenon Hospital, Assistance Publique Hôpitaux de Paris (APHP), and Faculty Medicine Sorbonne University, Paris, France.

Background: Although therapeutic lateral neck dissection (LND) may be indicated in thyroid carcinoma, the cervical lymph node groups IIA and IIB, according to Robbins classification, are often not removed. The aim of our study was to determine the relevance of complete comprehensive LND in thyroid carcinoma.

Methods: We conducted a retrospective study between January 2011 and August 2018 in a university teaching hospital. Read More

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December 2020

Factors Influencing the Relationship of the External Branch of the Superior Laryngeal Nerve with the Superior Pole Vessels of the Thyroid Gland.

Sisli Etfal Hastan Tip Bul 2020 11;54(4):469-474. Epub 2020 Dec 11.

Department of General Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Teaching and Research Hospital, Istanbul, Turkey.

Objectives: In a thyroidectomy, the external branch of the superior laryngeal nerve (EBSLN) is a potential risk during the superior pole dissection due to its close anatomical relationship with the superior thyroid artery and its highly variable anatomy. In this study, we aimed to evaluate the relationship of EBSLN with the superior pole considering Cernea classification and the factors affecting this relationship.

Methods: The data of thyroidectomized 126 patients (95 female, 31 male) with 200 neck sides (mean age of 45. Read More

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December 2020

Pediatric laryngeal tumors and demographics, management, and survival in laryngeal squamous cell carcinoma.

Int J Pediatr Otorhinolaryngol 2021 Jan 18;140:110507. Epub 2020 Nov 18.

Department of Otolaryngology - Head and Neck Surgery, Boston Medical Center, Boston, MA, USA. Electronic address:

Objectives: To evaluate the prevalence and features of pediatric laryngeal malignancies and to review the demographics, management, and survival of pediatric patients with laryngeal squamous cell carcinoma as compared to adult patients.

Methods: Patients aged 0 (younger than 1) to 18 with laryngeal malignancy identified in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2016 published April 2019. Diagnosis of malignant laryngeal tumor was made using the 3rd edition of the International Classification of Diseases for Oncology (ICDO-3) code: C32. Read More

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January 2021

Predictive factors of cervical nodal metastases in N0 squamous cell carcinomas of the mobile tongue - A cohort study.

Ann Med Surg (Lond) 2020 Dec 10;60:403-407. Epub 2020 Nov 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Ibn Rochd Hospital, King Hassan II University, Morocco.

Squamous cell carcinoma (SCC) of the tongue is one of the most common cancers in the oral region, most frequently associated with lymph nodes metastases which influence the most the prognosis. The identification of predictive factors of occult cervical nodal metastases for N0 tumors will allow to adapt the treatment to the patient, avoiding over or under management. From 2014 to 2019, a cohort of 26 patients with SCC of the mobile tongue was reviewed by analysing the medical history, the epidemiological and clinical parameters, the tumor sites, aspects, diameters, depths of invasion, pathological degree, degree of differentiation, T classification and results of neck dissections. Read More

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December 2020

Retromandibular vein position and course patterns in relation to mandible: anatomical morphologies requiring particular vigilance during sagittal split ramus osteotomy.

Anat Cell Biol 2020 Dec;53(4):444-450

epartment of Oral Pathobiological Science and Surgery, Tokyo Dental College, Tokyo, Japan.

Major bleeding associated with sagittal split ramus osteotomy (SSRO) involves vessels such as the inferior alveolar, facial, and maxillary arteries and veins, and the retromandibular vein (RMV). The present study aimed to clarify and classify the three-dimensional variations in RMV position and course direction in relation to the mandible. Specimens comprised a total of 15 scientific cadavers, and the relationship between RMV and the mandible lateral and posterior views was observed. Read More

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December 2020

Functional outcomes after extracapsular dissection with partial facial nerve dissection for small and large parotid neoplasms.

Am J Otolaryngol 2021 Jan - Feb;42(1):102770. Epub 2020 Oct 22.

Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA. Electronic address:

Purpose: Multiple surgical options exist for benign parotid tumors without agreement upon a single, best approach. We evaluated the short-term outcomes and rate of complications using the ECD-FND technique for small and large parotid neoplasms involving the superficial and deep lobes of the parotid gland using a categorical approach.

Material And Methods: A single surgeon retrospective cohort study with analysis of patient demographics, outcomes, and complication rates was conducted of patients undergoing the ECD-FND for benign parotid neoplasm. Read More

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October 2020

Sequencing of Sclerosing Microcystic Adenocarcinoma Identifies Mutational Burden and Somatic Variants Associated With Tumorigenesis.

Anticancer Res 2020 Nov;40(11):6375-6379

Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, CT, U.S.A.

Background/aim: Sclerosing microcystic adenocarcinoma (SMA) is a rare oral cavity neoplasia, histologically resembling microcystic adnexal carcinoma (MAC) of the skin. Only nine SMA cases have been reported in the literature, frequently in the context of immunosuppression; SMA has not been recognized in the most recent WHO tumor classification. We sought to identify potential molecular mechanisms of tumorigenesis in a case of SMA relative to those known for MAC. Read More

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November 2020

MR evaluation of tongue carcinoma in the assessment of depth of invasion with histopathological correlation: A single center experience.

Reddy Ravikanth

Indian J Radiol Imaging 2020 Apr-Jun;30(2):126-138. Epub 2020 Jul 13.

Department of Radiology, Holy Family Hospital, Thodupuzha, Kerala, India.

Introduction: Magnetic resonance imaging (MRI) has become the cornerstone for pretreatment evaluation of carcinoma tongue and provides accurate information regarding the extent of the lesion and depth of invasion that helps the clinician to optimize treatment strategy. Aim of the study is to correlate MRI and histopathological findings, to evaluate the role of MRI in loco-regional tumor node metastasis (TNM) staging, and to assess the depth of invasion of tongue carcinoma.

Materials And Methods: This study was undertaken on 30 patients with clinical diagnosis of tongue carcinoma referred for MR imaging at a tertiary care hospital over the 2-year period between July 2017 and June 2019. Read More

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Real-time drug detection using a diathermic knife combined to rapid evaporative ionisation mass spectrometry.

Talanta 2021 Jan 21;221:121391. Epub 2020 Jul 21.

Toxicology and Pharmacology, KU Leuven, 3000, Leuven, Belgium; Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, 6229, ER, Maastricht, the Netherlands. Electronic address:

Fast, accurate and sensitive detection of drugs in human tissue is of crucial importance in an investigation of a suspicious death. Here, we aimed to screen cocaine, diazepam, methadone and morphine in post-mortem muscle samples without sample preparation and in quasi-real time using rapid evaporative ionisation mass spectrometry (REIMS). REIMS enables the online MS analysis of vapours generated from tissue dissection by a diathermic knife. Read More

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January 2021

Efficacy of polyglycolic acid sheets and fibrin glue for the prevention of post-ELPS bleeding.

Auris Nasus Larynx 2021 Jun 13;48(3):471-476. Epub 2020 Oct 13.

Divisions of Otolaryngology-Head and Neck Surgery, Ise Red Cross Hospital, Mie, Japan. Electronic address:

Objective: To assess the efficacy and safety of a covering method using polyglycolic acid (PGA) sheets and fibrin glue in preventing laryngopharyngeal bleeding after endoscopic laryngopharyngeal surgery (ELPS) combined with endoscopic submucosal dissection (ESD).

Methods: Twenty-one patients who underwent ELPS combined with ESD (28 resected pharyngeal carcinomas) were retrospectively evaluated. After completing ELPS combined with ESD, fibrinogen was sprayed onto the ulcer. Read More

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[Factors affecting selection of tracheostomy after mandibular tumor operation: a retrospective study].

Shanghai Kou Qiang Yi Xue 2020 Jun;29(3):329-332

Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine. Shanghai 200127, China.

Purpose: To assess the factors affecting selection of tracheostomy after mandibulectomy.

Methods: The clinical data of 165 patients who were divided into intubated group and tracheostomy group were collected from January 2008 to December 2012 in Shanghai Ninth People's Hospital, including demographics, smoke habits, alcohol consumption, pulmonary disease, American Society of Anesthesiologists (ASA) physical status classification, history of jaw operation, length of surgery, preoperative radiotherapy, free flap reconstruction, resection over the anterior midline, and radical neck dissection. The postoperative outcomes, such as the duration of keeping tube, the length of ICU stay, the length of hospital stay, and the number of complications and death were collected. Read More

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Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma.

J Clin Invest 2020 11;130(11):5833-5846

Division of Surgical Oncology, National Cancer Centre Singapore, Singapore.

Angiosarcomas are rare, clinically aggressive tumors with limited treatment options and a dismal prognosis. We analyzed angiosarcomas from 68 patients, integrating information from multiomic sequencing, NanoString immuno-oncology profiling, and multiplex immunohistochemistry and immunofluorescence for tumor-infiltrating immune cells. Through whole-genome sequencing (n = 18), 50% of the cutaneous head and neck angiosarcomas exhibited higher tumor mutation burden (TMB) and UV mutational signatures; others were mutationally quiet and non-UV driven. Read More

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November 2020

Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies.

Laryngoscope 2021 04 2;131(4):E1198-E1208. Epub 2020 Oct 2.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

Objectives: Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck treatment are still controversial. Nasal reconstruction is challenging, as well, and prosthesis is still used.

Study Design: Retrospective cohort study. Read More

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Prognostic importance of harvested lymph node number, metastatic lymph node number, and lymph node ratio in surgically managed laryngeal squamous cell carcinoma.

Braz J Otorhinolaryngol 2020 Sep 10. Epub 2020 Sep 10.

Health Science University Bakırköy Dr Sadi Konuk Research and Training Hospital, Istanbul, Turkey.

Introduction: Lymph node metastasis is a well-known prognostic factor for laryngeal carcinoma. However, current nodal staging systems provide limited information regarding prognosis. Additional parameters should be considered to improve prognostic capacity. Read More

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September 2020