756 results match your criteria Neck Dissection Classification


Meta-analysis of risk of occult lymph node metastasis in the irradiated, clinically N0 neck.

Head Neck 2020 May 19. Epub 2020 May 19.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, San Diego, California, USA.

Background: Recurrent head and neck squamous cell carcinoma (HNSCC) after radiation is associated with poor survival, and management of the clinically negative (N0) neck during salvage surgery is controversial.

Methods: Studies were selected according to preferred reporting items for systematic reviews and meta-analyses guidelines. Inclusion criteria were patients with HNSCC, prior radiation to the lateral neck nodal basin, undergoing salvage surgery for local recurrence, persistence or second primary, and N0 at time of salvage. Read More

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http://dx.doi.org/10.1002/hed.26248DOI Listing

Elective neck dissection in patients with salivary gland carcinoma: A systematic review and meta-analysis.

J Oral Pathol Med 2020 May 20. Epub 2020 May 20.

Research Unit for ORL Head & Neck Surgery and Audiology, Odense University Hospital and University of Southern Denmark, Odense, Denmark.

Objective: Elective neck dissection in patients with salivary gland carcinoma and clinical negative lymph nodes is controversial. Reported proportion of occult nodal metastases vary with histological subtype, tumour classification and preoperative diagnostic methods. This is a systematic review and meta-analysis on the role of END in salivary gland carcinoma. Read More

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http://dx.doi.org/10.1111/jop.13034DOI Listing

Effects of active localization and vascular preservation of inferior parathyroid glands in central neck dissection for papillary thyroid carcinoma.

World J Surg Oncol 2020 May 13;18(1):95. Epub 2020 May 13.

Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan Street, Gulou District, Nanjing, 210011, NO, China.

Background: The purpose of present study is to assess the effects of active localization and vascular preservation of inferior parathyroid glands in central neck dissection (CND) for papillary thyroid carcinoma (PTC).

Methods: A classification of IPGs according to their location and vascular features was developed, and, based on this classification, a CND procedure was designed, and IPGs and their vascular were actively localized and strategically preserved. A total of 197 patients with PTC who underwent a total thyroidectomy and concomitant CND were enrolled. Read More

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http://dx.doi.org/10.1186/s12957-020-01867-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222446PMC

Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review.

Cancers (Basel) 2020 Apr 24;12(4). Epub 2020 Apr 24.

International Head and Neck Scientific Group, 35100 Padua, Italy.

Background: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define the prevalence of occult metastasis based on the subsite of the primary tumor, T classification and neck node levels involved. Read More

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http://dx.doi.org/10.3390/cancers12041059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225965PMC

Tumor histologic grade as a risk factor for neck recurrence in patients with T1-2N0 early tongue cancer.

Oral Oncol 2020 Apr 21;106:104706. Epub 2020 Apr 21.

Department of Radiation Oncology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan. Electronic address:

Objectives: In current guidelines, early tongue cancer status post partial glossectomy without adverse risk features do not require adjuvant treatment. However, many of these patients developed recurrence with neck metastases soon. The objectives of this study were to investigate the potential risk factors in early tongue cancer that prophylactic management of neck may be considered. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104706DOI Listing

Misdiagnosis of Cervicocephalic Artery Dissection in the Emergency Department.

Stroke 2020 Apr 16:STROKEAHA120029390. Epub 2020 Apr 16.

Clinical and Translational Neuroscience Unit, Department of Neurology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY (B.B.N., C.Z., H.K., A.E.M.).

Background and Purpose- Cervicocephalic artery dissection is an important cause of stroke. The clinical presentation of dissection can resemble that of benign neurological conditions leading to delayed or missed diagnosis. Methods- We performed a retrospective cohort study using statewide administrative claims data from all Emergency Department visits and admissions at nonfederal hospitals in Florida from 2005 to 2015 and New York from 2006 to 2015. Read More

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http://dx.doi.org/10.1161/STROKEAHA.120.029390DOI Listing

The high sub-mandibular approach: Our experience about 496 procedures.

J Stomatol Oral Maxillofac Surg 2020 Mar 20. Epub 2020 Mar 20.

Department of Oral and Maxillofacial Surgery, University Hospital of Besançon, 3, boulevard Fleming, 25030 Besançon cedex, France; Nanomedicine Lab Imagery and Therapeutics (EA 4662), University of Franche-Comté, 19, rue Ambroise-Paré, 25000 Besançon, France. Electronic address:

Introduction: The potential drawbacks of surgical approaches to neck and base fractures of the mandibular condyle (visible scare, facial nerve injury) are still considered by many surgeons as a brake for open reduction and internal fixation. The aim of our study was to analyze the results in terms of access, scare quality and complications that could be noticed in a 12 years period of time with the use of the high sub-mandibular approach (HSMA) we first described in 2006 for the surgical treatment of neck and base fractures.

Material And Method: All the files of patients operated on for condylar neck and base fractures approached by mean of a HSMA between January 2006 and December 2018 in our department and containing information concerning age, sex, type of fracture, kind of osteosynthesis material, operating time, name of the surgeon, postoperative complication linked to the approach, scare quality at 6 months follow-up at least were included. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.03.009DOI Listing

Residual esophageal necrosis after radical esophagectomy for esophagogastric cancer: A case report.

Mol Clin Oncol 2020 Apr 18;12(4):321-324. Epub 2020 Feb 18.

Department of Gastroenterological Surgery, Chiba Cancer Center, Chiba 260-8717, Japan.

A 66-year-old man was diagnosed with advanced esophagogastric junction cancer and referred to our institution (Department of Gastroenterological Surgery, Chiba Cancer Center) for treatment. Computed tomography imaging confirmed the presence of a tumor, extending from the lower thoracic esophageal to the esophagogastric junction, with swelling of the upper mediastinal lymph nodes. Based on the criteria of the International Union against Cancer Committee (UICC, 8th Edition), the staging was confirmed as follows: 101R, 107 and 106 pre. Read More

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http://dx.doi.org/10.3892/mco.2020.1997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057976PMC

A Case of Late Diagnosis of Acute Aortic Dissection Involving the Carotid Arteries in a Patient Presenting with Signs of Acute Ischemic Stroke.

Am J Case Rep 2020 Mar 5;21:e919271. Epub 2020 Mar 5.

Department of Emergency Medicine, Jamaica Hospital Medical Center, Queens, NY, USA.

BACKGROUND Acute aortic dissection (AAD) is a rare but life-threatening condition with high mortality. The Stanford classification of aortic dissection includes type A, which originates in the ascending aorta, and type B, which originates in the descending aorta. The diagnosis may be missed due to its ability to mimic other more common cardiovascular conditions. Read More

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http://dx.doi.org/10.12659/AJCR.919271DOI Listing

Carcinomas of the Thyroid with Ewing Family Tumor Elements (CEFTEs): A Diagnostic Challenge Before Surgery.

Head Neck Pathol 2020 Feb 19. Epub 2020 Feb 19.

Endocrine and Metabolic Disease Department, Regina Apostolorum Hospital, Albano Laziale, Rome, Italy.

Carcinomas of the thyroid with Ewing family tumor elements (CEFTEs) are small cell thyroid tumors characterized by epithelial differentiation and EWSR1-FLI1 rearrangements. In contrast to primary thyroid Ewing sarcomas, these rare tumors have a favorable prognosis. CEFTEs may co-exist with papillary thyroid carcinoma (PTC) foci and are thought to arise from either PTCs or main cells of solid cell nests (SCN). Read More

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http://dx.doi.org/10.1007/s12105-020-01145-zDOI Listing
February 2020

Polypoid gallbladder neuroendocrine tumor diagnosed as benign polyp before surgery: A case report.

Mol Clin Oncol 2020 Mar 24;12(3):225-229. Epub 2019 Dec 24.

Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka 814-0180, Japan.

Gallbladder neuroendocrine tumors (GB-NETs) comprise only 0.5% of all NET cases, and their biology has been incompletely characterized. In the present study we report the case of a 50-year-old male patient with GB-NET who was admitted to Naito Hospital with diarrhea as the main complaint. Read More

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http://dx.doi.org/10.3892/mco.2019.1971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017218PMC

The necessity of level IIb dissection for clinically negative neck oral squamous cell carcinoma.

J Stomatol Oral Maxillofac Surg 2020 Feb 25. Epub 2020 Feb 25.

Department of Maxillofacial Surgery, CHU de Bordeaux, 33000 Bordeaux, France.

Aim: Selective neck dissection reduces the incidence of complications associated with radical neck dissection while achieving the same oncological results, especially in clinically node-negative (cN0) cases. The most common complications associated with selective neck dissection are spinal accessory nerve dysfunction and shoulder disability, which result from level IIb dissection. The aim of the present study was to evaluate the incidence of level IIb lymph node metastasis in cN0 oral squamous cell carcinoma (OSCC) patients to determine the necessity of selective neck surgery. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.02.001DOI Listing
February 2020

Positive Lymph Node Counts in American Thyroid Association Low-Risk Papillary Thyroid Carcinoma Patients.

World J Surg 2020 Jun;44(6):1892-1897

THANC (Thyroid, Head and Neck Cancer) Foundation, 10 Union Square East, New York, NY, 10003, USA.

Background: Current American Thyroid Association (ATA) guidelines state that patients with intermediate-risk papillary thyroid cancer (PTC) may benefit from remnant ablation. One criterion for intermediate-risk classification is >5 positive lymph nodes (LNs). We investigate whether performing step-sectioning of LNs increases the metastatic detection rate, thereby influencing ATA risk of recurrence (ROR) classification. Read More

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http://dx.doi.org/10.1007/s00268-020-05399-0DOI Listing

Extracapsular extension of neck nodes and absence of human papillomavirus 16-DNA are predictors of impaired survival in p16-positive oropharyngeal squamous cell carcinoma.

Cancer 2020 Jan 7;126(9):1856-1872. Epub 2020 Feb 7.

Clinic for Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Leipzig, Germany.

Background: Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinomas (OPSCCs) demonstrate superior outcome compared with HPV-negative OPSCCs. The eighth edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor, lymph node, metastasis (TNM) classification (TNM 2017) modifies OPSCC staging based on p16 positivity as a surrogate for HPV-driven disease. In p16-negative OPSCCs, lymph node (N) categories include extracapsular/extranodal extension (ECE); and, in p16-positive OPSCCs, N categories are based on the number of positive neck lymph nodes omitting ECE status. Read More

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http://dx.doi.org/10.1002/cncr.32667DOI Listing
January 2020

Classifying Neck Lymph Nodes of Head and Neck Squamous Cell Carcinoma in MRI Images with Radiomic Features.

J Digit Imaging 2020 Jan 16. Epub 2020 Jan 16.

Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University, No. 5, Fu-Hsing ST., Kwei-Shan, Linkou, Taoyuan, Taiwan.

The aim of this study is to develop a computer-aided diagnosis method to help classify medical images of neck lymph nodes in head and neck cancer patients. According to the current practice guidelines, the classification of lymph node status is critical for patient stratification before treatment. Take extra-nodal extension (ENE) of metastatic neck lymph nodes, the status of ENE has been considered a single factor affecting the decision of whether systemic treatment with toxicity should be given to patients with otherwise non-advanced cancer status. Read More

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http://dx.doi.org/10.1007/s10278-019-00309-wDOI Listing
January 2020

Selective neck dissection in the treatment of head and neck squamous cell carcinoma patients with a clinically positive neck.

Oral Oncol 2020 Jan 13;102:104565. Epub 2020 Jan 13.

Department of Otolaryngology, Hospital Universitario Central de Asturias, ISPA, IUOPA, University of Oviedo, CIBERONC, Oviedo, Spain.

Objective: To determine the effectiveness and outcomes of SND in the treatment of patients with squamous cell carcinoma of the head and neck (SCCHN) with clinically positive neck (cN+) at diagnosis.

Material And Methods: We retrospectively reviewed 159 patients with SCCHN with cN+ at diagnosis, who underwent a SND with curative intent at a tertiary care academic teaching hospital in Spain. We registered patient and tumor characteristics, date and site of recurrences, together with the outcomes. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104565DOI Listing
January 2020

Mammary analogue secretory carcinoma of the minor salivary gland: report of two cases.

Int J Clin Exp Pathol 2019 1;12(12):4338-4343. Epub 2019 Dec 1.

Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College Bengbu 233000, Anhui, P. R. China.

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour notable for a balanced chromosomal translocation t(12;15)(p13;q25) that contributes to ETV6 gene rearrangements. It was first reported in 2010 by Skalova et al. with histological features resembling secretory carcinoma of the breast and was acknowledged and referred to as "secretory carcinoma" in the updated 2017 WHO classification. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949877PMC
December 2019
1.783 Impact Factor

Predicting the factors associated with central lymph node metastasis in clinical node-negative (cN0) papillary thyroid microcarcinoma.

Eur Arch Otorhinolaryngol 2020 Apr 13;277(4):1191-1198. Epub 2020 Jan 13.

Department of Medical Ultrasound, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin, 150081, China.

Purpose: The aim of the present study was to investigate the risk factors associated with central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC).

Methods: A total of 553 patients with PTMC confirmed by histological examination, who underwent thyroidectomy and central neck dissection (CND), were enrolled. The clinicopathological and ultrasonographic features from the patients were analyzed retrospectively. Read More

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http://dx.doi.org/10.1007/s00405-020-05787-1DOI Listing

Comparison of clinicopathological features in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features and follicular variant papillary thyroid cancer.

Pol Arch Intern Med 2020 02 2;130(2):100-105. Epub 2020 Jan 2.

Department of Endocrinology and Metabolism, Medical Faculty, Trakya University, Edirne, Turkey

Introduction: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly defined entity accepted as a tumor precursor.

Objectives: We aimed to examine the features of patients diagnosed with follicular variant papillary thyroid carcinoma (FVPTC), which are classified as NIFTP in the recent classification. This study compares clinical, radiological, histopathological, and molecular featur es of NIFTP and FVPTC. Read More

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http://dx.doi.org/10.20452/pamw.15120DOI Listing
February 2020

Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up.

Lasers Med Sci 2020 Apr 13;35(3):751-758. Epub 2019 Dec 13.

Department of Interdisciplinary Medicine, University of Bari, Piazza G. Cesare, 11, 70124, Bari, Italy.

The management of patients with early stage (cT1-T2) tongue squamous cell carcinoma without clinicoradiologic evidence of neck node metastasis (cN0) has been widely debated over the last 3 decades and still remains controversial. Nevertheless, the identification of patients with low-stage tumours at high-risk for occult cervical metastases is imperative before planning treatments of primary tumours, as well as that of prognostic markers which may possibly select those patients who may benefit of additional workup after surgery in view of the high metastatic potential of the primary tumour. The pre-surgical evaluation of tongue malignant primary tumour (for assessing lateral and deep margins) along with diode laser surgery (with accurate incision, bleeding-free and with reduced/absent post-surgical complications) may lead to a more conservative but equally decisive surgical treatment, also with a greater patient compliance. Read More

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http://dx.doi.org/10.1007/s10103-019-02932-zDOI Listing

The Endoscopic Relationship of the Stapedius Muscle to the Facial Nerve: Implications for Retrotympanic Surgery.

Otol Neurotol 2019 Oct 23. Epub 2019 Oct 23.

Department of Otolaryngology and Head and Neck Surgery, Royal North Shore Hospital, St Leonards.

Objectives: The stapedius muscle, tendon, and pyramidal eminence are structures within the retrotympanum. In cholesteatoma surgery, the retrotympanum is a common site of residual disease. The removal of the pyramidal eminence during surgery is sometimes necessary to obtain better visualization of the superior retrotympanum during surgery. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002454DOI Listing
October 2019

The Endoscopic Relationship of the Stapedius Muscle to the Facial Nerve: Implications for Retrotympanic Surgery.

Otol Neurotol 2020 01;41(1):e64-e69

Department of Otolaryngology and Head and Neck Surgery, Royal North Shore Hospital, St Leonards.

Objectives: The stapedius muscle, tendon, and pyramidal eminence are structures within the retrotympanum. In cholesteatoma surgery, the retrotympanum is a common site of residual disease. The removal of the pyramidal eminence during surgery is sometimes necessary to obtain better visualization of the superior retrotympanum during surgery. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002454DOI Listing
January 2020

Ten patients with high-grade transformation of acinic cell carcinomas: Expression profiling of β-catenin and cyclin D1 is useful.

Pathol Res Pract 2020 Feb 30;216(2):152767. Epub 2019 Nov 30.

THANC (Thyroid, Head and Neck Cancer) Foundation, 10 Union Square East, Suite 5B, New York, NY, 10003, USA; Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai Hospital, Mount Sinai Beth Israel, 10 Union Square East, Suite 5B, New York, NY, 10003, USA.

Conventional acinic cell carcinoma (CACC) represents a prototypical low-grade salivary malignancy. Rarely, acinic cell carcinoma (ACC) can demonstrate aggressive features (zones of necrosis, apoptosis, varying nuclear atypia) warranting classification as "ACC with high-grade transformation" (HGT-ACC) or "dedifferentiated" ACC. This study reports ten new cases of HGT-ACC. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152767DOI Listing
February 2020

Efficacy of prophylactic central neck dissection in hemithyroidectomy for papillary thyroid carcinoma.

Eur Arch Otorhinolaryngol 2020 Mar 2;277(3):873-879. Epub 2019 Dec 2.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.

Purpose: To evaluate the efficacy of prophylactic central neck dissection (pCND) in hemithyroidectomy for clinically node-negative papillary thyroid carcinoma (PTC).

Methods: We retrospectively analyzed 299 patients who underwent thyroid lobectomy with or without pCND for unilateral PTC. Of the 299 patients, 245 (81. Read More

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http://dx.doi.org/10.1007/s00405-019-05744-7DOI Listing

[Current Standard of Care in Squamous Cell Carcinoma of the Head and Neck (SCCHN) - Prevention, diagnostics, prognostication and therapy].

Dtsch Med Wochenschr 2019 12 2;144(24):1691-1696. Epub 2019 Dec 2.

Westdeutsches Tumorzentrum, Schwerpunkt interdisziplinäre Uroonkologie, Universitätsklinikum Essen.

The standard of care in squamous cell carcinoma of the head and neck (SCCHN) has recently undergone some major shifts in prevention, diagnostics, staging, prognostication and therapy.Prevention: Subtypes of the human papilloma virus (HPV) have been identified as causative agent for HPV-driven oropharyngeal carcinomas nearly two decades ago. Vaccination against HPV is now recommended for all girls and boys at the age of 9 to 14 years by the Standing Committee on Vaccination at the Robert Koch Institute (STIKO). Read More

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http://dx.doi.org/10.1055/a-0644-4439DOI Listing
December 2019

The influence of papillary thyroid microcarcinomas size on the occurrence of lymph node metastases.

J BUON 2019 Sep-Oct;24(5):2120-2126

Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Purpose: Lymph node metastases (LNM) in papillary thyroid microcarcinomas (PTMC) are common. PTMC greater than 5 mm are considered to be more aggressive. Tumor greater than 5 mm is predictive factor for occurrence of LNM in PTMC, although there are insufficient data regarding this fact. Read More

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April 2020
4 Reads
0.706 Impact Factor

Which Factors Affect the Long-Term Survival of Patients With Oral Squamous Cell Carcinoma With Distant Metastasis?

J Oral Maxillofac Surg 2020 Mar 31;78(3):469-478. Epub 2019 Oct 31.

Professor and Chairman, Department of Oral and Maxillofacial Surgery and Oral Cancer Center, Tokyo Dental College, Tokyo, Japan.

Purpose: The development of distant metastases (DMs) in patients with oral squamous cell carcinoma (OSCC) leads to dismal prospects for survival. The present study aimed to identify the risk factors for DM development and long-term survival.

Patients And Methods: The present study was a retrospective cohort study of patients with OSCC at a single institution. Read More

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http://dx.doi.org/10.1016/j.joms.2019.10.018DOI Listing

Classification of Naso Septal Deviation Angle and its Clinical Implications: A CT Scan Imaging Study of Palakkad Population, India.

Indian J Otolaryngol Head Neck Surg 2019 Nov 8;71(Suppl 3):2004-2010. Epub 2018 Jun 8.

Department of Anatomy, Karuna Medical College, Palakkad, Kerala 678103 India.

Computerized tomographic imaging of the nasal and paranasal regions has become an indispensable tool for the endoscopic sinonasal surgery. The case control study was carried out on 120 patients for pilot study and 800 patients for the main study. The cases were selected with a clinical diagnosis of chronic rhino sinusitis. Read More

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http://dx.doi.org/10.1007/s12070-018-1425-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848586PMC
November 2019

A Study on Neck Nodes in Oral Cancers, with Special Reference to Skip Metastasis.

Indian J Otolaryngol Head Neck Surg 2019 Oct 16;71(Suppl 1):474-481. Epub 2018 Apr 16.

1Department of ENT, Maulana Azad Medical College, New Delhi, India.

To analyse the distribution of Neck metastases (NM) and to study frequency of skip metastases in oral squamous cell carcinoma (SCC) of oral cavity. From September 2012 to April 2013, 30 previously untreated patients with SCC of oral cavity underwent primary surgical treatment in our institution. From pathological report of Neck dissection specimen prevalence and distribution of NM were ascertained. Read More

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http://dx.doi.org/10.1007/s12070-018-1360-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848720PMC
October 2019

Prognostic value of lymph node density for major salivary gland carcinoma without clinical lymph node metastasis.

Am J Otolaryngol 2020 Jan - Feb;41(1):102304. Epub 2019 Oct 5.

Department of Head and Neck Surgery, Asahi University Hospital, Gifu, Japan. Electronic address:

Background And Objective: This study aimed to investigate whether lymph node density (LND) was correlated with overall survival (OS) in major salivary gland carcinoma without clinical lymph node metastasis.

Methods: Sixty patients who were diagnosed with major salivary gland carcinoma without clinical lymph node metastasis were enrolled. Of these, 50 patients underwent neck dissection. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.102304DOI Listing

Anatomical-based classification for transoral lateral oropharyngectomy.

Oral Oncol 2019 12 7;99:104450. Epub 2019 Nov 7.

Humanitas University, Via Rita Levi Montalcini, 4, 20090 Pieve Emanuele (MI), Italy; Department of Otorhinolaryngology Head and Neck Surgery, IRCCS Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089 Rozzano (MI), Italy.

Purpose: The aim of the study is proposing a classification of different transoral lateral oropharyngectomy procedures in order to ensure better definitions of post-operative results.

Methods: The classification resulted from the consensus of the different authors and was based on anatomical-surgical principles.

Results: The classification comprises three types of lateral oropharyngectomy: type 1 is the resection of the palatine tonsil deep to the pharyngobasilar fascia; type 2 is performed by removing the entire palatine tonsil, the palatoglossus muscle, the palatopharyngeal muscle and the superior constrictor muscle; type 3 is performed by removing the entire palatine tonsil, the palatoglossus muscle, the palatopharyngeal muscle, the superior constrictor muscle, the buccopharyngeal fascia with extension to the pterygoid muscle and parapharyngeal space fat content. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.104450DOI Listing
December 2019

Clinically Node-Negative Parotid Gland Cancers: Prognostic Factors of Survival and Surgical Extent.

Oncology 2020 23;98(2):102-110. Epub 2019 Oct 23.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objective: Conservative parotidectomy is known to reduce morbidity, but has been rarely examined in patients with clinically node-negative (cN0) parotid cancers. We evaluated the clinicopathological variables influencing the outcomes of these patients and the efficacy of conservative parotidectomy.

Methods: We reviewed the clinical and pathological data of 256 patients with cN0 parotid carcinomas who underwent curative surgery at our institution. Read More

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http://dx.doi.org/10.1159/000503580DOI Listing
February 2020
2 Reads

Dysphagia After Primary Transoral Robotic Surgery With Neck Dissection vs Nonsurgical Therapy in Patients With Low- to Intermediate-Risk Oropharyngeal Cancer.

JAMA Otolaryngol Head Neck Surg 2019 Sep 26. Epub 2019 Sep 26.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Importance: A major goal of primary transoral robotic surgery (TORS) for oropharyngeal cancer is to optimize swallowing outcomes by personalized treatment based on pathologic staging. However, swallowing outcomes after TORS are uncertain, as are the outcomes compared with nonsurgical options.

Objectives: To estimate rates of acute dysphagia and recovery after TORS and to compare swallowing outcomes by primary treatment modality (TORS or radiotherapy). Read More

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http://dx.doi.org/10.1001/jamaoto.2019.2725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763976PMC
September 2019
8 Reads

The Prognostic Significance of Lymph Node Ratio and Log Odds Ratio in Laryngeal Squamous Cell Carcinoma.

OTO Open 2018 Jul-Sep;2(3):2473974X18792008. Epub 2018 Sep 27.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Centre, Guangzhou, Guangdong, P.R. China.

Objective: To investigate whether lymph node ratio (LNR) and log odds ratio (LODDS) have prognostic significance for overall survival (OS) and disease-free survival (DFS) in patients with laryngeal squamous cell cancer (LSCC) treated with curative intent.

Study Design: Case-control study.

Setting: University hospital. Read More

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http://dx.doi.org/10.1177/2473974X18792008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737873PMC
September 2018
2 Reads

Preoperative Ultrasonographic Staging of Papillary Thyroid Carcinoma With the Eighth American Joint Committee on Cancer Tumor-Node-Metastasis Staging System.

Ultrasound Q 2019 Jul 17. Epub 2019 Jul 17.

Department of Ultrasound, Ruijin Hospital.

Objective: The purpose of this study was to evaluate the performance of preoperative ultrasonography (US) in the staging of papillary thyroid carcinoma (PTC) according to the eighth AJCC TNM classification system, to determine the effect of the preoperative US staging in the management of PTC.

Patients And Methods: Preoperative US was performed by 2 highly trained sonographers in 665 consecutive patients with PTC, and the T and N categories were determined preoperatively. The accuracy of preoperative US in clinical staging was evaluated based on the histopathological specimens according to the eighth AJCC TNM classification. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000469DOI Listing
July 2019
2 Reads

Efficacy of hemithyroidectomy in papillary thyroid carcinoma with minimal extrathyroidal extension.

Eur Arch Otorhinolaryngol 2019 Dec 14;276(12):3435-3442. Epub 2019 Aug 14.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, 222 Wangsimniro, Seongdong-gu, Seoul, 04763, Republic of Korea.

Purpose: This study aimed to compare the oncologic outcomes of hemithyroidectomy with total thyroidectomy in clinically node-negative (cN0) papillary thyroid carcinoma (PTC) with minimal extrathyroidal extension (ETE).

Methods: Among 1826 PTC patients who underwent thyroidectomy from Jan 2001 to Dec 2014, there were 255 with unilateral cN0 PTC with minimal ETE and of equal to or less than 2 cm in size; these 255 patients were included in this study. We excluded patients who had tumor size > 2 cm, bilateral tumors, clinically positive nodes, maximal or no ETE, gross invasion of sternothyroid muscle, recurrent cancers or distant metastases. Read More

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http://dx.doi.org/10.1007/s00405-019-05598-zDOI Listing
December 2019
1 Read

Study of Sigmoid Sinus Variations in the Temporal Bone by Micro Dissection and its Classification - A Cadaveric Study.

Int Arch Otorhinolaryngol 2019 Jul 28;23(3):e311-e316. Epub 2019 May 28.

Department of Otorhinolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

 Sigmoid sinus (SS) variations have been classified variously in the literature. These classifications suffer from some form of shortcoming from a clinical point of view for their application.  We propose a clinically relevant classification of the SS in relation to the posterior semicircular canal (PSCC) and to the exposure of the presigmoid dural plate. Read More

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http://dx.doi.org/10.1055/s-0039-1688455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660287PMC
July 2019
2 Reads

Metastatic lymph node burden predictive of survival in patients undergoing primary surgery for laryngeal and hypopharyngeal cancer.

J Cancer Res Clin Oncol 2019 Oct 27;145(10):2565-2572. Epub 2019 Jul 27.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: Metastatic lymph node (LN) burden is one of the most important prognosticators in human solid cancers, but has rarely been examined in laryngeal and hypopharyngeal cancers (LHC). We evaluated the nodal factors predictive of recurrence and survival in patients with LHC.

Methods: This study included 141 consecutive patients who underwent primary surgery and neck dissection for previously untreated LHC at our tertiary referral centre. Read More

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http://dx.doi.org/10.1007/s00432-019-02990-4DOI Listing
October 2019
5 Reads

Risk factors for neck hematoma requiring surgical re-intervention after thyroidectomy: a systematic review and meta-analysis.

BMC Surg 2019 Jul 24;19(1):98. Epub 2019 Jul 24.

Department of Hepatic Surgery and Liver transplantation Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: In this systematic review and meta-analysis, we aimed to determine the risk factors associated with neck hematoma requiring surgical re-intervention after thyroidectomy.

Methods: We systematically searched all articles available in the literature published in PubMed and CNKI databases through May 30, 2017. The quality of these articles was assessed using the Newcastle-Ottawa Quality Assessment Scale, and data were extracted for classification and analysis by focusing on articles related with neck hematoma requiring surgical re-intervention after thyroidectomy. Read More

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http://dx.doi.org/10.1186/s12893-019-0559-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657038PMC
July 2019
9 Reads

Parotid pleomorphic adenomas: Factors influencing surgical techniques, morbidity, and long-term outcome relative to the new ESGS classification in a retrospective study.

J Craniomaxillofac Surg 2019 Sep 26;47(9):1356-1362. Epub 2019 Jun 26.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg, Waldstrasse 1, 91054, Erlangen, Germany. Electronic address:

Purpose: To assess long-term results after treatment of parotid pleomorphic adenomas (PPAs) with different surgical techniques, standardized according to the European Salivary Gland Society (ESGS) classification system.

Methods: We analyzed ESGS categories, occurrence of facial nerve paresis (FNP), Frey's syndrome, histopathology, and recurrences. Surgical modalities were compared, differentiating techniques with and without facial nerve dissection. Read More

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http://dx.doi.org/10.1016/j.jcms.2019.06.009DOI Listing
September 2019
3 Reads

Tracheal agenesis with esophageal atresia: an autopsy case report of a variant incompatible with life.

Fetal Pediatr Pathol 2020 Feb 17;39(1):45-50. Epub 2019 Jul 17.

Arkadi M. Rywlin M.D., Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

: Tracheal agenesis/atresia (TA) presents with respiratory distress at birth and subsequent difficulty in endotracheal intubation. The antenatal course is complicated by polyhydramnios and premature labor. : We present a newborn baby boy with respiratory distress and unsuccessful intubation. Read More

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http://dx.doi.org/10.1080/15513815.2019.1627628DOI Listing
February 2020
7 Reads

Tumor-related leukocytosis predictive of recurrence and survival in patients with oral cavity squamous cell carcinoma.

Oral Dis 2019 Sep 25;25(6):1511-1518. Epub 2019 Jun 25.

Departments of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: To evaluate the prognostic values of tumor-related leukocytosis (TRL) as a reliable biomarker predictive of recurrence and survival after definitive surgery for oral cavity squamous cell carcinoma (OSCC).

Materials And Methods: This retrospective study involved 322 patients who underwent tumor extirpation combined with neck dissection for treatment-naïve OSCC between 2006 and 2014. Multivariate binary logistic regression analyses were used to analyze the relationship between TRL and pathological variables. Read More

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http://dx.doi.org/10.1111/odi.13138DOI Listing
September 2019
3 Reads

Metabolic tumor volume of metastatic lymph nodes and survival after total laryngectomy in laryngeal and hypopharyngeal cancer.

Oral Oncol 2019 06 2;93:107-113. Epub 2019 May 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan. Electronic address:

Objectives: The prognostic value of metabolic tumor volume (MTV) in locally advanced laryngeal or hypopharyngeal cancer is established in the setting of chemoradiotherapy, while it remains unknown in the setting of upfront total laryngectomy.

Materials And Methods: We retrospectively analyzed 88 patients receiving total laryngectomy and neck dissection, using Cox regression models.

Results And Conclusion: Variables related to metastatic lymph node were associated with overall survival, whereas those related to primary tumor were not. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.04.011DOI Listing
June 2019
5 Reads

Extranodal extension is a strong prognosticator in HPV-positive oropharyngeal squamous cell carcinoma.

Laryngoscope 2020 Apr 11;130(4):939-945. Epub 2019 May 11.

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, Missouri, U.S.A.

Objective: To comprehensively examine the prognostic significance of extranodal extension (ENE) in human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC).

Methods: Retrospective cohort of cases diagnosed with HPV-positive OPSCC from 2010 to 2015 in the National Cancer Database. Inclusion of all OPSCC HPV-positive cases with appropriate International Classification of Diseases-0-3 codes that received surgery with a neck dissection. Read More

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http://dx.doi.org/10.1002/lary.28059DOI Listing
April 2020
6 Reads

Differences in management outcome for first branchial cleft anomalies: A comparison of infants and toddlers to older children.

Int J Pediatr Otorhinolaryngol 2019 Jul 11;122:161-164. Epub 2019 Apr 11.

Division of Pediatric Otolaryngology Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA; Department of Otolaryngology, McGaw Medical Center of Northwestern University, Chicago, IL, USA.

Objective: First branchial cleft anomalies (FBCAs) are rare and often misdiagnosed, which can delay proper management and increase surgical risks. Complete excision often requires parotidectomy with facial nerve dissection. The literature reports that younger patients more often have lesions deep to the nerve with higher rates of nerve injury. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.009DOI Listing
July 2019
6 Reads

Addition of tumour infiltration depth and extranodal extension improves the prognostic value of the pathological TNM classification for early-stage oral squamous cell carcinoma.

Histopathology 2019 Sep 29;75(3):329-337. Epub 2019 Jul 29.

Department of Oral and Maxillofacial Surgery, University of Groningen, Groningen, The Netherlands.

Aims: In the 8th edition of the American Joint Committee on Cancer TNM staging manual, tumour infiltration depth and extranodal extension are added to the pathological classification for oral squamous cell carcinoma. The currently available 8th TNM validation studies lack patients with conservative neck treatment, and changes in the classification especially affect patients with small tumours. The aim of this study was to determine the potential impact of the changes in the 8th edition pTNM classification on the prognosis and treatment strategy for oral squamous cell carcinoma in a well-defined series of pT1-T2 patients with long-term follow-up. Read More

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http://dx.doi.org/10.1111/his.13886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851684PMC
September 2019
10 Reads

Predicting recurrence of papillary thyroid cancer using the eighth edition of the AJCC/UICC staging system.

Br J Surg 2019 06 23;106(7):889-897. Epub 2019 Apr 23.

Department of Surgery, University of California at San Francisco, San Francisco, California, USA.

Background: The AJCC/UICC classification is widely used for predicting survival in papillary thyroid cancer (PTC), but has not been evaluated as a predictor of recurrence. The hypothesis of this study was that the eighth edition of the AJCC system can be used in this novel way.

Methods: All patients in the study underwent surgery for PTC at a high-volume endocrine surgery centre in France between 1985 and 2015. Read More

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http://dx.doi.org/10.1002/bjs.11145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825520PMC
June 2019
3 Reads

Machine learning to predict occult nodal metastasis in early oral squamous cell carcinoma.

Oral Oncol 2019 05 16;92:20-25. Epub 2019 Mar 16.

Department of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, 3901 Rainbow Boulevard M.S. 3010, Kansas City, KS, USA.

Objectives: To develop and validate an algorithm to predict occult nodal metastasis in clinically node negative oral cavity squamous cell carcinoma (OCSCC) using machine learning. To compare algorithm performance to a model based on tumor depth of invasion (DOI).

Materials And Methods: Patients who underwent primary tumor extirpation and elective neck dissection from 2007 to 2013 for clinical T1-2N0 OCSCC were identified from the National Cancer Database (NCDB). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.011DOI Listing
May 2019
8 Reads

Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.

Oncol Lett 2019 May 4;17(5):4717-4725. Epub 2019 Mar 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, P.R. China.

Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 and 2010 was conducted. Read More

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http://dx.doi.org/10.3892/ol.2019.10104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447886PMC
May 2019
20 Reads

High-grade Features of Papillary Cystadenocarcinoma of the Parotid Gland.

Oman Med J 2019 Mar;34(2):164-168

Department of Radiology, Baylor College of Medicine, Houston, Texas.

Papillary cystadenocarcinomas (PCAs) are rare low-grade salivary gland tumors first introduced in the World Health Organization classification in 1991. While classically regarded as a low-grade malignancy, PCAs with more clinically and histologically high-grade features have been reported, reflecting the often-underrecognized morphological diversity of this entity. Although no universally advocated grading system exists, high-grade PCAs tend to demonstrate locally aggressive features, cytologic atypia, high mitotic rate, necrosis, and an absence of papillary features. Read More

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http://dx.doi.org/10.5001/omj.2019.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425058PMC
March 2019
6 Reads