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Medicine (Baltimore) 2019 Apr;98(16):e15250

Department of Head and Neck Cancer Center.

Rationale: Adenoid cystic carcinoma (ACC) is an infrequent malignant neoplasm of the salivary glands. The clinical and pathological characteristics include slow growth, perineural invasion, and local recurrence. ACC of the mobile tongue is rarely reported in the literature. Read More

Mol Clin Oncol 2019 May 15;10(5):524-530. Epub 2019 Mar 15.

Department of Pathology, Santa Maria delle Croci Hospital, AUSL of Romagna, I-48121 Ravenna, Italy.

Recurrent differentiated thyroid carcinoma can easily be detected by means of ultrasound (US) and thyroglobulin, and often requires further surgical intervention. Revision surgery is often a technical challenge with significant risk of complications, considering the altered anatomy, with a possibility of leaving behind residual neoplasm. Preoperative US-guided tattooing localization has been introduced to reduce and prevent these potential problems during revision surgery. Read More

J Laryngol Otol 2019 Apr 22:1-6. Epub 2019 Apr 22.

Department of Otorhinolaryngology - Head and Neck Surgery,Medical Faculty,Comenius University in Bratislava,Slovakia.

Objective: This study aimed to determine the incidence of metastatic squamous cell carcinoma in patients with an isolated cervical cystic mass, and to describe the clinical features that might predict the origin of cystic tumours.

Method: Adult patients with isolated lateral cervical cystic masses who were scheduled for surgery from 1st January 2010 to 31st August 2016 in two tertiary care referral centres in Slovakia were analysed retrospectively.

Results: The incidence of cystic metastases in the whole cohort and in patients aged over 40 years were 9. Read More

Radiother Oncol 2019 May 31;134:10-16. Epub 2019 Jan 31.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Canada. Electronic address:

Background: This study aimed to derive distant metastases (DM) risk-groups in oral cavity squamous cell carcinoma (OSCC) patients treated with postoperative intensity-modulated radiation therapy (PO-IMRT).

Methods: OSCC patients treated with PO-IMRT were divided into discovery (2005-2012) and validation (2013-2014) cohorts. DM predictors were identified from multivariable analysis (MVA) to derive low- and high-risk groups in the discovery-cohort. Read More

Ann Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Background: Preoperative factors that reliably predict lymph node (LN) metastases in pancreatic neuroendocrine tumors (PanNETs) are unclear. The number of LNs needed to accurately stage PanNETs has not been defined.

Methods: Patients who underwent curative-intent resection of non-functional PanNETs at eight institutions from 2000 to 2016 were analyzed. Read More

Eur Arch Otorhinolaryngol 2019 Apr 19. Epub 2019 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.

Background: Papillary thyroid carcinoma frequently metastasizes to central and lateral neck lymph nodes, but metastasis to retropharyngeal lymph nodes (RPLN) is rare.

Patients And Methods: We retrospectively reviewed 16 patients with RPLN metastasis of PTC who underwent therapeutic dissection of RPLN metastases.

Results: Among 16 patients, 7 patients underwent RPLN dissection with initial surgery and remaining 9 patients as salvage surgery. Read More

Endocr Pract 2019 Apr;25(4):328-334

Well-differentiated thyroid cancer (WDTC) is characterized by favorable disease course and excellent survival. However, some histologic subtypes, known as aggressive histologic variants (AHVs), present a more aggressive behavior than conventional WDTC. The aim of this study was to evaluate the pattern of nodal involvement and factors influencing prognosis in N1b patients with AHVs. Read More

Clin Med Insights Oncol 2019 2;13:1179554919838254. Epub 2019 Apr 2.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of New Mexico Hospital, UNM School of Medicine, Albuquerque, NM, USA.

Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue.

Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Read More

Mol Biol Rep 2019 Apr 12. Epub 2019 Apr 12.

Department of Public Health and Pediatric Sciences, University of Turin, Via Santena 9, 10126, Turin, Italy.

The aim of the present study is to determine the expression levels of PYHIN (IFI16 and AIM2) and APOBEC3 (A3A, A3B, A3C, A3D, A3F, A3G, and A3H) gene family members in a cohort of patients with head and neck squamous cell carcinoma (HNSCC) and assess their potential correlation with human papillomavirus (HPV) infection status, clinical characteristics, and survival. For this purpose, 34 HNSCC tissue specimens along with healthy surrounding mucosa were collected from patients surgically treated for HNSCC. Nucleic acids were isolated to assess the presence of HPV and the expression levels of selected molecular markers. Read More

ANZ J Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Head and Neck Surgery, Liverpool Hospital, Sydney, New South Wales, Australia.

Background: Existing prognostic systems for metastatic cutaneous squamous cell carcinoma of the head and neck (cSCCHN) do not discriminate between the number of involved nodes beyond single versus multiple. This study aimed to determine if the number of metastatic lymph nodes is an independent prognostic factor in metastatic cSCCHN and whether it provides additional prognostic information to the American Joint Committee on Cancer (AJCC) staging.

Methods: We retrospectively analysed 101 patients undergoing curative intent treatment for metastatic cSCCHN to parotid and/or neck nodes by surgery +/- radiotherapy at Liverpool Hospital, Sydney, Australia. Read More

J Med Imaging Radiat Oncol 2019 Apr 11. Epub 2019 Apr 11.

Department of Otolaryngology, Head and Neck Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australia.

Background: Extracapsular spread (ECS) of lymph node metastases is associated with poor prognosis and is an indication for adjuvant chemoradiotherapy. Accurately identifying ECS using imaging may allow us to recommend primary chemoradiotherapy to avoid trimodality treatment. We investigated the accuracy of staging CT in diagnosing ECS in P16 + oropharyngeal squamous cell carcinoma (OPSCC). Read More

Front Oncol 2019 26;9:191. Epub 2019 Mar 26.

Department of Otolaryngology, Head and Neck Surgery, University of Leipzig, Leipzig, Germany.

Induction chemotherapy (ICT) is an attractive option for advanced head and neck squamous cell carcinoma (HNSCC) patients which has been prospectively evaluated in the context of a multimodality treatment approach. The theoretical benefit is the ability to suppress distant metastases and shrink the tumor while chemotherapy is better tolerated when given sequentially than concurrently. However, clinical trials have failed to show consistent benefit of ICT over concurrent radio-chemotherapy and due to so far lacking level 1 evidence ICT outside larynx organ preservation remains rather investigational. Read More

Radiat Oncol 2019 Apr 11;14(1):61. Epub 2019 Apr 11.

Department of Radiation Oncology, Kaohsiung Medical University Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.

Background: This study investigated the impact of post-radiation sinusitis on the prognosis of nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radiation therapy (IMRT).

Methods: Two hundred and thirty patients with non-metastatic NPC were analyzed in terms of freedom from local failure (FFLF), freedom from distant failure (FFDF), overall survival (OS), and disease-free survival (DFS). For each patient, the status of the sinus mucosa was flexibly assessed by documenting mucosal changes as indicated by differences between images obtained before radiotherapy and more than 6 months post-radiation. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):337-341

Department of Otolaryngology Head and Neck, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.

To investigate the feasibility of endoscopic surgery for treatment of rT1-rT2 recurrent nasopharyngeal carcinoma. The clinical data and of 57 patients who had recurrence of the primary lesion after treatment of nasopharyngeal carcinoma from February 2011 to December 2015 were retrospectively analyzed. The patients were re-staged according to Union for International Cancer Control(UICC, 2010) staging system for nasopharyngeal carcinoma before surgery. Read More

Open Access Maced J Med Sci 2019 Mar 14;7(5):791-793. Epub 2019 Mar 14.

Center for Physical and Rehabilitative Medicine, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Cutaneous squamous cell carcinoma (SCC) of the hand is the most common soft-tissue malignancy in this particular region. A literature survey suggested a higher rate of metastases in advanced SCC of the hand compared to head-and-neck cutaneous SCC.

Case Report: An 84-year-old man presented with an ulcerated firm tumour on the dorsum of his right hand. Read More

Auris Nasus Larynx 2019 Apr 3. Epub 2019 Apr 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Lymph node metastasis from signet ring cellcarcinoma (SRCC) primary unknown is extremely rare. We here report a case of primary-unknown SRCC that metastasized to the cervical lymph nodes, co-existing with mucoepidermoid carcinoma (MEC) of the parotid gland as a simultaneous double cancer. A 68-year-old female patient with right swollen cervical lymph nodes consulted our medical center. Read More

Laryngoscope 2019 Apr 5. Epub 2019 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Objectives/hypothesis: The definition of large-volume pathologic N1 metastases has been changed in the 2017 version 2 of the National Comprehensive Cancer Network guidelines, leading to a controversy over the optimal surgical approach selection for patients with biopsy-proven papillary thyroid carcinoma (PTC). The aim of this study was to investigate the therapeutic efficacy of total thyroidectomy (TT) and thyroid lobectomy (TL) for these patients.

Study Design: Retrospective population-based database analysis. Read More

Oncol Lett 2019 May 28;17(5):4229-4236. Epub 2019 Feb 28.

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.

Benefits of subdividing small-differentiated thyroid carcinoma (sDTC) by tumor size are controversial. We conducted a meta-analysis to investigate whether tumor size is associated with prognosis of sDTC. PubMed and Web of Science databases were searched from their inception to September 2018. Read More

Adv Otorhinolaryngol 2019 12;83:35-46. Epub 2019 Feb 12.

Department of Radiology, University of Brescia, Brescia, Italy.

Pre-treatment clinical and radiological evaluations represent a key step in the proper management of hypopharyngeal carcinoma. First, office-based endoscopy allows the assessment of superficial tumor extension, signs of laryngeal infiltration, and the overall residual function of the laryngo-hypopharyngeal complex. Different tools, maneuvers, and techniques can improve this essential diagnostic step and should be considered a prerequisite to direct subsequent investigations and give an initial indication for the most appropriate treatment. Read More

Adv Otorhinolaryngol 2019 12;83:27-34. Epub 2019 Feb 12.

Department of Otolaryngology, Head and Neck Surgery, Nottingham University Hospital NHS Trust, Queens Medical Centre Campus, Nottingham, United Kingdom.

Patients with hypopharyngeal cancers frequently present at advanced stage and in poor general health status. Their natural history is characterised by diffuse local primary disease, mucosal and submucosal spread, early cervical nodal metastasis, and a relatively high rate of distant spread. By the time of initial diagnosis, some 60% of all hypopharyngeal cancer patients will be with stage IV disease, some 5% will present with distant metastases, and almost 40% will have a significant reduction in performance status. Read More

Adv Otorhinolaryngol 2019 12;83:167-175. Epub 2019 Feb 12.

Department of Otolaryngology, Head and Neck Surgery, Nottingham University Hospital NHS Trust, Queens Medical Centre Campus, Nottingham, United Kingdom.

Recent advances in minimal access surgery have shown promise in the treatment of limited hypopharyngeal lesions. In spite of their functionally excellent results in individual patients, it currently remains unlikely that these approaches will gain a more major universal impact on hypopharyngeal cancer care. In advanced stage hypopharyngeal cancer, the use of the traditional radical surgery, such as laryngo-pharyngectomy, is no longer accepted by many patients. Read More

Head Neck 2019 Apr 3. Epub 2019 Apr 3.

Division of Otolaryngology and Head and Neck Surgery, European Institute of Oncology IRCCS, Milan, Italy.

Background: We investigated the role of the soft tissue tract between the primary tumor and the neck lymph nodes, the "T-N tract," in patients with tongue squamous cell carcinoma at an advanced stage.

Methods: We performed a compartmental tongue surgery in 233 patients. Cumulative incidence of relapses and overall survival curves were compared by T-N tract involvement. Read More

Int J Surg Oncol 2019 28;2019:6109643. Epub 2019 Feb 28.

Sultan Ismail Hospital, Johor Bahru 81100, Malaysia.

Introduction: Therapeutic nodal dissection is still the mainstay of treatment for patients with lymph node metastases in many centres. The local data, however, on the outcome of therapeutic LND remains limited. Hence, this study aims to inform practice by presenting the outcomes of LND for thyroid cancer patients and our experience in a tertiary referral centre. Read More

Dermatol Surg 2019 Mar 28. Epub 2019 Mar 28.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.

Background: Atypical fibroxanthoma (AFX) is a rare dermal neoplasm typically occurring on sun-exposed skin in the elderly. As AFX remains a diagnosis of exclusion, updated characterization and treatment assessments are necessary to support informed diagnosis and management.

Objective: Characterization of contemporary AFX and surgical outcomes by Mohs micrographic surgery (MMS) and conventional local excision (LE). Read More

Ear Nose Throat J 2019 Mar 15;98(3):158-164. Epub 2019 Feb 15.

1 Department of Otolaryngology-Head & Neck Surgery, Augusta University, Augusta, GA, USA.

The objective of our study is to assess the impact of equivocal or positive positron emission tomography combined with low-dose noncontrast computed tomography (PET/CT) findings in the chest on treatment for head and neck cancer (HNC). We reviewed charts of patients presented at Augusta University's Head and Neck Tumor Board (AUTB) between 2013 and 2016 with the following exclusion criteria: <18 years, Veterans Affairs patients, those with incomplete data, and those without a history of head and neck squamous cell carcinoma. The lung/thorax sections of the radiologists' PET/CT reports were graded as "Positive, Equivocal, or Negative" for chest metastases. Read More

Oncogene 2019 Apr 1. Epub 2019 Apr 1.

Department of Otolaryngology-Head and Neck Surgery, Loma Linda University Medical Center, Loma Linda, CA, 92354, USA.

Tumor recurrence following treatment remains a major clinical challenge in oral cavity cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been considered as the driving force of tumor recurrence and metastasis. However, it still remains unclear whether targeting CSCs in oral cancer is a clinically relevant strategy to combat cancer recurrence and metastasis. Read More

Melanoma Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, Eye Pathology Section.

This study aimed to investigate the microRNA (miRNA) profile in primary tumors from conjunctival melanoma with and without subsequent metastatic spread along with their coupled distant metastases to identify miRNAs likely to be involved in metastatic progression. This observational study included 13 patients with metastatic conjunctival melanoma (follow-up: 1-39 years) treated at a Danish referral center. Twenty-five patients with nonmetastatic conjunctival melanoma (follow-up: 5-17 years) were included for comparison. Read More

Auris Nasus Larynx 2019 Mar 28. Epub 2019 Mar 28.

Department of Head and Neck Surgery, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.

Lingual lymph node metastases are rarely seen in carcinoma of the tongue, and these nodes are not removed during neck dissection. Lingual lymph nodes are classified into medial and lateral groups, and metastasis to the former is extremely rare. A 55-year-old male with squamous cell carcinoma of the tongue, (stage T4aN0M0), underwent hemiglossectomy with neck dissection and free flap reconstruction. Read More

Radiol Clin North Am 2019 May 14;57(3):485-500. Epub 2019 Feb 14.

Department of Radiological Sciences, University of Oklahoma Health Sciences Center, College of Medicine, P.O. Box 2690, Garrison Tower, Suite 4G4250, Oklahoma City, OK 73126, USA.

Ultrasonography is an excellent method for imaging evaluation of cervical lymph nodes. This article provides an image-rich review of the sonographic manifestations of diseases involving the cervical lymph nodes, with an emphasis on the expected anatomic distribution of diseases. Read More

Oral Oncol 2019 Apr 6;91:97-106. Epub 2019 Mar 6.

Department of Otolaryngology, Head and Neck Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Head and Neck Studies and Education, University of Birmingham, UK; Institute of Cancer and Genomic Sciences, University of Birmingham, UK. Electronic address:

Background: The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication.

Method: Systematic review and meta-analysis of studies employing TORS or TLM in diagnosis of the unknown primary tumor site in patients with cervical nodal metastases of squamous cell origin. Read More

J Craniomaxillofac Surg 2019 Mar 9. Epub 2019 Mar 9.

University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany; University of Saarland, Department of Oral and Maxillofacial Surgery, Kirrberger Straße, D-66424, Homburg, Germany.

Introduction: The aim of this retrospective study was to evaluate the incidence of regional metastases in squamous cell carcinoma (SCC) of the tongue, in order to validate different neck management regime recommendations.

Materials And Methods: A cohort of 97 patients suffering from primary SCC of the tongue was analyzed in regard to the development of primary and late neck node metastases, considering tumor stage and affected side. Survival analysis was performed to determine the impact of different relevant clinical and pathological factors on overall and progression-free survival. Read More

Eurasian J Med 2019 Feb 3;51(1):8-11. Epub 2018 Dec 3.

Department of General Surgery, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Objective: Thyroid-stimulating hormone/thyrotropin (TSH) is known to induce malignancies and tissue growth of the thyroid gland. While the relationship of higher levels of TSH with advanced stages of cancer had been published in previous studies, the relationship of the tumor with the clinicopathological factors had not been completely evaluated. The aim of the present study was to evaluate the relationship between highly risky clinicopathological factors with preoperative high levels of TSH. Read More

Head Neck 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, University of Florida College of Medicine, Jacksonville, Florida.

Purpose: To evaluate the rate and risk factors of isolated leptomeningeal progression in sinonasal carcinomas.

Methods: We retrospectively reviewed imaging and clinical records to determine progression patterns, and estimated rates using the Kaplan-Meier method. We evaluated risk factors using proportional hazard regression. Read More

Acta Chir Belg 2019 Mar 25:1-7. Epub 2019 Mar 25.

d Department of Anatomopathology, Hotel-Dieu de France Hospital, Faculty of Medicine , Saint-Joseph University , Beirut , Lebanon.

Background: High-resolution sonography is becoming a method of choice for the detection and diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). The purpose of this study is to assess the diagnostic accuracy of neck ultrasound (US) in the detection of lymph node metastases from PTC.

Methods: Data for all patients with papillary thyroid cancers and preoperative neck US were reviewed retrospectively. Read More

Horm Cancer 2019 Mar 22. Epub 2019 Mar 22.

Department of Surgical Oncology, Faculty of Medicine - Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Piso 3, Santiago, Chile.

The use of BRAFV600E and RET/PTC1 as biomarkers to guide the extent of surgery in patients with papillary thyroid cancer (PTC) remains controversial. We assessed the combined use of demographic data (sex and age) with mRNA expression levels and/or mutational status (BRAFV600E and RET/PTC1) to identify potential subsets of patients with aggressive histopathological features (lymph node metastases and extrathyroidal extension). In a cohort of 126 consecutive patients, BRAFV600E and RET/PTC1 mutations were found in 52 and 18%, respectively. Read More

Am J Transl Res 2019 15;11(2):904-910. Epub 2019 Feb 15.

Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical College Bengbu 233004, Anhui, P. R. China.

Background: Nasopharyngeal carcinoma (NPC) is a kind of head-neck malignant neoplasm originated from the nasopharyngeal epithelium and is mainly prevalent in Southern China and Southeast Asia countries. KiSS-1 is an inhibitor of tumor metastasis in a range of cancers.

Methods: We establish a cell substrain of SUNE-1-5-8F (NPC cell line from humans) that trsnfected with lentiviral vectors carried with KiSS-1 gene and were selected by puromycin. Read More

Ann Otol Rhinol Laryngol 2019 Mar 20:3489419837574. Epub 2019 Mar 20.

1 Department of Surgery-Division of Otolaryngology-Head and Neck Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Objective:: To identify and evaluate patients with parotid bed malignancy demonstrating radiographic findings of auriculotemporal (AT) nerve involvement.

Methods:: A retrospective review of patients with parotid bed malignancy was performed to identify patients with imaging findings of AT nerve involvement and record associated clinical findings, symptoms, and pathology information. Independent, blinded review of radiographic images by a senior neuroradiologist was performed to identify imaging characteristics and categorize patients into highly likely or possible involvement groups. Read More

PLoS One 2019 20;14(3):e0213934. Epub 2019 Mar 20.

Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy.

Background: We conducted a multicenter retrospective analysis to describe the characteristics, frequency of skeletal-related events (SREs), and prognosis of head and neck cancer (HNC) in patients with bone metastases (BM).

Patients And Methods: The data of 192 HNC patients with BMs were collected. Analyses were conducted separately in 64 nasopharyngeal cancer (NPC) patients and in 128 non-NPC patients. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14602

Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital.

Background: p16 protein is significantly down-regulated in several cancers, which reveals that it may be a potential biomarker for cancers. However, the clinicopathological and prognostic value of p16 protein in nasopharynx cancer patients remains unclear. Therefore, we performed a meta-analysis to assess the relationships of p16 protein expression with the clinicopathological features and prognosis of nasopharynx cancer. Read More

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurosurgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, and is associated with high recurrence and low survival rates; however, distant brain metastasis from NPC is rare. The authors report 3 cases of brain metastasis from NPC treated with stereotactic radiosurgery (SRS). A 49-year-old woman presented was diagnosed with brain metastasis from NPC, which occurred 53 months after initial diagnosis of NPC. Read More

Surgery 2019 Mar 12. Epub 2019 Mar 12.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Lymph node metastases from papillary thyroid cancer is believed to disseminate sequentially, first to the central neck and later to the lateral neck. Skip metastases of papillary thyroid cancer, however, are defined as lateral lymph node metastasis without central lymph node metastasis. The aim of this study was to investigate the risk factors for skip metastases and lateral lymph node metastasis of papillary thyroid cancer. Read More

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):134-135

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Prostate carcinoma is one of the most common cancers in males all around the world. Head and neck squamous cell carcinoma is amongst the leading carcinoma (HNSCC) in men especially in the sub-continent. There are around 150 lymph nodes on either side in the neck and cervical lymph nodes are a common site for head and neck malignancies to metastasize however carcinoma of prostate may in rare cases metastasize to cervical chain, therefore warranting a neck dissection. Read More

AJR Am J Roentgenol 2019 Mar 12:1-8. Epub 2019 Mar 12.

1 Department of Radiology, University of Minnesota Medical Center, Fairview, 420 Delaware St SE, B-226 Mayo Memorial Bldg, MMC 292, Minneapolis, MN 55455.

Objective: The aim of this study is to assess the utility of pretreatment whole-body F-FDG PET/CT in screening for distant metastasis (DM) and regional lymphatic metastasis (LM).

Materials And Methods: Eighty-nine consecutive patients with untreated sinonasal malignant lesions (32 women and 57 men; mean age, 62 years) underwent whole-body FDG PET/CT between January 2009 and August 2017. A retrospective analysis was performed to determine the presence of DM and LM. Read More

Auris Nasus Larynx 2019 Mar 8. Epub 2019 Mar 8.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: The purpose of this study was to evaluate the usefulness of ultrasound (US) volume measurement of the cervical lymph nodes for diagnosing nodal metastasis in patients with head and neck cancer using a node-by-node comparison.

Methods: Thirty-four consecutive patients with head and neck cancer from one tertiary university hospital were prospectively enrolled from 2012 to 2017. Patients with histologically proven squamous cell primary tumors in the head and neck region scheduled to undergo a therapeutic neck dissection were eligible. Read More

Otolaryngol Head Neck Surg 2019 Mar 12:194599819835779. Epub 2019 Mar 12.

3 Department of Otolaryngology, NYU Langone Health, New York, New York, USA.

Objective: Clear cell carcinoma (CCC) is a rare salivary gland malignancy, believed to be generally low grade. We investigated CCC epidemiology and clinical behavior, using the National Cancer Database (NCDB).

Study Design: Retrospective cohort study. Read More

Am J Case Rep 2019 Mar 11;20:318-322. Epub 2019 Mar 11.

Osteopathic Medical Student, University of Pikeville-Kentucky College of Osteopathic Medicine, Pikeville, KY, USA.

BACKGROUND Sarcomas account for less than 1% of all cancers. Undifferentiated Pleomorphic Sarcoma, formerly called Malignant Fibrous Histiocytoma, is a rare subtype identified by a lack specific immunohistochemical markers for a specific lineage of differentiation. These soft tissue tumors are aggressive and rapidly enlarge. Read More

Auris Nasus Larynx 2019 Mar 5. Epub 2019 Mar 5.

Department of Otolaryngology - Head and Neck Surgery, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan.

Secondary carcinogenesis within the irradiation range is one of the most severe problems in cancer survivors. A 60-year-old woman developed hypopharyngeal carcinoma, and she received radical surgery and postoperative radiotherapy. Eight years later, brown pigmentation and induration were observed in the left subaural region. Read More

Thyroid 2019 Apr;29(4):471-479

2 Department of Internal Medicine, Division of Endocrinology, Department of Biochemistry, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas.

Hürthle cell tumors (HCT), including Hürthle cell adenomas (HCA) and Hürthle cell carcinomas (HCCs), arise in the thyroid gland and are defined in part by an accumulation of mitochondria. These neoplasms were long considered a subtype of follicular neoplasm, although HCT is now generally considered a distinct entity. HCTs exhibit overlapping but distinct clinical features compared to follicular tumors, and several studies have demonstrated that HCTs harbor distinct genomic alterations compared to other forms of thyroid cancer. Read More

Oral Oncol 2019 Mar 10;90:87-93. Epub 2019 Feb 10.

Coordinator of the International Head and Neck Scientific Group, Italy.

In 1994 a decision analysis, based on the literature and utility ratings for outcome by a panel of experienced head and neck physicians, was presented which showed a threshold probability of occult metastases of 20% to recommend elective treatment of the neck. It was stated that recommendations for the management of the cN0 neck are not immutable and should be reconfigured to determine the optimal management based on different sets of underlying assumptions. Although much has changed and is published in the almost 25 years after its publication, up to date this figure is still mentioned in the context of decisions on treatment of the clinically negative (cN0) neck. Read More

Oral Oncol 2019 Mar 1;90:45-47. Epub 2019 Feb 1.

Augusta University, Department of Otolaryngology-Head and Neck Surgery, Augusta, GA 30912, United States.

Malignant conversion of sinonasal inverted papilloma (SNIP) occurs in approximately ten percent of cases. These tumors are classically described as locally destructive, but without metastatic potential. Only four cases of malignant conversion with cervical nodal metastases have been described in the English literature. Read More