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Aktuelle Urol 2018 Dec 6;49(6):519-524. Epub 2018 Dec 6.

Spital Thurgau AG, Urologie, Frauenfeld.

The classical algorithm of the management of male lower urinary tract symptoms (LUTSs) due to benign prostatic hyperplasia (BPH) includes a surgical approach in case pharmacological therapy has failed. Emerging minimally-invasive treatments (MITs) offer potential for rapid symptomatic relief, reducing the morbidity of invasive BPH surgery. Convective interstitial radiofrequency water vapour thermal ablation of the prostate with the Rezūm system is a novel MIT for the treatment of bothersome moderate-to-severe lower urinary tract symptoms associated with BPH. Read More

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Background: Plaque characteristics play pivotal roles in ischemic events, but stenosis severity does not accurately reflect carotid plaque volume due to expansive remodeling in some patients with low-grade stenosis (LGS).

Objective: This study aimed to assess the safety, efficacy, and durability of carotid endarterectomy (CEA) for symptomatic LGS.

Methods: Study participants comprised 61 consecutive patients who underwent CEA for symptomatic carotid stenosis. Read More

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Otolaryngology Department, Hospital Clínic, Barcelona, Spain.

Background: Indications of transoral laser microsurgery (TLM) are conditioned by the risk of local relapse.

Objective: To evaluate prognostic factors of local relapse and local control with TLM (LC-TLM).

Methods: Local relapse and LC-TLM were evaluated in 1119 patients. Read More

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.

Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.

Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The aim of this study was to evaluate the feasibility, safety, and early surgical outcomes of transoral thyroidectomy and to compare robotic and endoscopic procedures.

Methods: A total of 37 patients underwent robotic (23 cases) or endoscopic (14 cases) transoral thyroidectomy. We compared the outcomes of the two procedures. Read More

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

Neuroscience Research Australia and The University of New South Wales, Sydney, Australia.

Briefly occluding the airway during inspiration produces a short-latency reflex inhibition in human inspiratory muscles. This occlusion reflex seems specific to respiratory muscles; however, it is not known whether the reflex inhibition has a uniform effect across a motoneurone pool when a muscle is recruited concurrently for breathing and posture. In this study, participants were seated and breathed through a mouthpiece that occluded inspiratory airflow for 250 ms at a volume threshold of 0. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Neuro-Urology, CTO - Spinal Unit, Città della Salute e della Scienza di Torino, Turin, Italy.

Purpose: The aim of our study is to evaluate the efficacy and safety of ATOMS® system for the treatment of postoperative male stress urinary incontinence (SUI).

Materials And Methods: We retrospectively evaluated all patients treated at our institution for postoperative male SUI with ATOMS® implant. We excluded patients with low bladder compliance (< 20 mL / cmH2O), uncontrolled detrusor overactivity, detrusor underactivity (BCI < 100), urethral or bladder neck stricture and low cystometric capacity (< 200 mL). Read More

Int Braz J Urol 2018 Sep 20;44. Epub 2018 Sep 20.

Department of Urology, Korea University Ansan Hospital, Korea University College of Medicine, Korea.

Introduction And Objective: Perforation of the bladder or urethra and erosion of the mesh after cystocele repair surgery are not uncommon and have potentially serious complications. Traditionally, surgical management of such complications has involved excision of the mesh using either a transurethral approach or open surgery. In this video, we present our experience of laparoscopic transvesical surgery for exposed mesh and stone. Read More

Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.

Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: The prognostic value of the first posttreatment whole body integrated positron emission tomography-computed tomography (PET/CT) scanning in patients with sinonasal/skull base malignancies is undetermined.

Methods: We retrospectively reviewed the data of all patients that underwent surgery for sinonasal/skull base malignancies in 2000-2015. The results of the pretreatment and posttreatment PET/CT findings and the clinical course were retrieved. Read More

Head Neck 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Johann Wolfgang Goethe University, Frankfurt, Germany.

Background: For locally recurrent head and neck cancer, re-irradiation with modern techniques like stereotactic body radiotherapy is a promising, possibly curative alternative to palliative systemic therapy.

Methods: We report on 1 patient with nasopharyngeal carcinoma (NPC) and 1 patient with cutaneous squamous cell carcinoma (SCC). Both patients received full dose primary treatment (>66 Gy, EQD2), full dose re-irradiation (>50 Gy, EQD2), and a second course of re-irradiation via robotic radiosurgery (CyberKnife) for a second local recurrence. Read More

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.

Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Baylor College of Medicine, Houston, Texas.

Background: Patients with head and neck cancer (HNC) experience significant physical and psychological morbidity during radiotherapy (RT) that contributes to treatment interruptions and a poor quality of life. Although spouses/partners can help by encouraging patient self-management (eg, self-care) during RT, they often experience high psychological distress rates, lack basic health care knowledge and skills, and report increased marital conflict regarding patient self-management. The current pilot study examined the feasibility and acceptability of a 6-session telephone-based intervention called Spouses coping with the Head And neck Radiation Experience (SHARE), which teaches self-management, communication, and coping skills to patients with HNC and their spouses. Read More

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

ENT Institute, Otorhinolaryngology Department, Eye and ENT Hospital of Fudan University, Shanghai, China.

Pain Med 2018 Dec 6. Epub 2018 Dec 6.

Faculty of Medicine and Health Sciences, The University of Newcastle, Newcastle, Australia.

Objectives.: To determine the extent and strength of evidence that supports the belief that cervical intervertebral discs are a source of neck pain. The evidence from anatomical, laboratory, experimental, diagnostic, and treatment studies was summarized and analyzed for concept validity, face validity, content validity, and construct validity. Read More

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Oklahoma State University Center for Health Sciences, Tulsa.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Psychiatry, New York State Psychiatric Institute, Vagelos College of Physicians and Surgeons, NewYork-Presbyterian/Columbia University Irving Medical Center, Columbia University, New York.

Importance: Age-related hearing loss is highly prevalent and has recently been associated with numerous morbid conditions of aging. Late-life depression is also prevalent and can be resistant to available treatments. Preliminary studies examining the association between hearing loss and late-life depression have been limited by subjective hearing measures, small sample sizes, and primarily white populations. Read More

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.

JAMA Otolaryngol Head Neck Surg 2018 Dec 6. Epub 2018 Dec 6.

Institute for Health and Equity (Bioethics and Medical Humanities), Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin.

Appl Immunohistochem Mol Morphol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Specialistic and Dental Sciences.

The present study investigated the immunohistochemical expression of p53, p63, and p73 in different types of odontogenic cysts (OC), a group of common intraosseous jaw lesions, to provide a better understanding of p53-family functions in odontogenic lesions. We carried out immunohistochemical analysis to evaluate the expression of p53, p63, and p73 in 60 samples of OC, including dentigerous cysts, radicular cysts, orthokeratinized OC, and odontogenic keratocysts (OKC). The epithelial expression of p53-family members was evaluated both in the basal-parabasal and in the superficial layers, measuring the percentage of positive cells and the value of expression intensity. Read More

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Otolaryngology-Head and Neck Surgery.

This study sought to examine if modern medical evaluations including newborn screening and early diagnosis along with better methods of disease control have improved rates of hearing loss in children with sickle cell disease (SCD). Audiometric and medical data for patients with SCD was obtained from the AudGen Database and analyzed for the presence of hearing loss, type of hearing loss, severity of hearing loss, and correlation with comorbid conditions. Children with sickle cell trait (SCT) were used as a comparison group. Read More

Saudi Med J 2018 Dec;39(12):1238-1241

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To determine the mean nasal skin thickness in the Middle Eastern population and to assess the effect of skin thickness on patients' satisfaction following rhinoplasty surgeries. Methods: Radiological measurements of skin thickness at the 3 vertical thirds of the nasal dorsum were taken. A total of 154 patients (80 females and 74 males) who were scheduled for computed tomography scan for the paranasal sinuses were included in the study. Read More

Public Health Nutr 2018 Dec 6:1-10. Epub 2018 Dec 6.

2Department of Nutrition and Health,Universidade Federal de Viçosa,Viçosa, MG,Brazil.

Objective: The present study aimed to investigate whether the visceral adiposity index (VAI) is an effective predictor to identify unhealthy metabolic phenotype by comparing normal-weight and overweight individuals.

Design: A population-based cross-sectional study. Data were collected by interviews, anthropometric evaluation, dietetic, clinical and laboratory tests. Read More

Scand J Surg 2018 Dec 6:1457496918816928. Epub 2018 Dec 6.

1 Heart Center, Turku University Hospital, Turku, Finland.

Background And Aims:: Cardiovascular complications are common in hip fracture patients but the role of fracture type and operative method in these is unclear. This prospective cohort study aimed to evaluate the impact of fracture- and operative characteristics on perioperative cardiovascular complications and prognosis in unselected hip fracture patients.

Material And Methods:: During a 7-month trial registration period, a population of 197 consecutive hip fracture patients (median age 84 years) diagnosed with femoral neck or pertrochanteric fracture was formed. Read More

Pediatr Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.

We evaluated the efficiency of using a 308-nm excimer laser with either tacrolimus, pimecrolimus, or halometasone for the treatment of childhood vitiligo. Patients who received combined treatments had significantly higher rates of repigmentation in comparison with individuals who underwent excimer laser alone therapy. Moreover, patients who received treatment with excimer laser and halometasone had significantly higher rates of repigmentation, even higher than individuals who were treated with tacrolimus combined or pimecrolimus combined. Read More

Laryngoscope 2018 Dec 5. Epub 2018 Dec 5.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Objectives/hypothesis: Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns. Read More

J Ultrasound 2018 Dec 5. Epub 2018 Dec 5.

Department of Physical Medicine and Rehabilitation, Sanggye Paik Hospital, Inje University College of Medicine, Sanggye 7 dong 761-7, Nowon-gu, 139-707, Seoul, South Korea.

Purpose: Recent studies have compared the therapeutic efficacy and safety of the procedure using ultrasound and fluoroscopy. However, there are no published studies comparing the therapeutic efficacy and safety of fluoroscopy (FL)-guided cervical interlaminar epidural steroid injection (CIESI) with that of ultrasound (US)-guided selective nerve root block (SNRB). This study aimed to compare the mid-term effects and advantages of US-guided SNRB with FL-guided CIESI for radicular pain in the lower cervical spine through assessment of pain relief and functional improvement. Read More

Forensic Sci Med Pathol 2018 Dec 5. Epub 2018 Dec 5.

Australian Marine Wildlife Research and Rescue Organization (AMWRRO), Adelaide, South Australia, 5000, Australia.

An adult male Australian sea lion (Neophoca cinerea) presented with a deep, almost circumferential, incised wound around the neck caused by a noose formed by a single strand of green nylon rope. The wound extended 4-5 cm deeply through the skin and blubber into skeletal muscle, predominantly on the dorsal surface and left side, but had not involved the airway or major vessels. The edges of the wound were sharply incised and oozing blood with a granulating infected base. Read More

Eur Arch Otorhinolaryngol 2018 Dec 5. Epub 2018 Dec 5.

Department of Otorhinolaryngology and Head Neck Surgery, SMS Medical College and Hospital, Jaipur, Rajasthan, 302004, India.

Introduction: Cochlear implantation is a boon to children with hearing loss. Rarely, it can be associated with complications. Soft tissue reaction can be a particularly distressing complication. Read More

Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.

Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.

Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More

Pharmacoeconomics 2018 Dec 6. Epub 2018 Dec 6.

Clinical Data Services and Analytics, UnitedHealthcare, 9700 Health Care Lane, Minnetonka, MN, 55343, USA.

Background: Opioid use and misuse are urgent health issues. Previous studies suggest that opioid use increases healthcare resource use but severity adjustment is lacking.

Objective: The objective of this study was to evaluate the severity-adjusted cost difference between opioid users and non-users among patients with conservatively managed degenerative joint disease of the spine within a large commercial health plan population in the United States. Read More

Esophagus 2018 Dec 5. Epub 2018 Dec 5.

JED (Japan Endoscopy Database) Project Committee, Japan Gastroenterological Endoscopy Society, Tokyo, Japan.

Purpose: The aim was to investigate the current status of esophageal endoscopy, including the evaluation of smoking and alcohol consumption, in Japan.

Methods: A total of 47,441 patients who underwent 69,748 sessions of esophageal endoscopy were registered in the Japan Endoscopy Database between January 2015 and March 2017. The study variables were as follows: (1) methods for monitoring the esophagus and the time required for monitoring and (2) the status of smoking and alcohol consumption in patients with esophageal cancer and head and neck cancer. Read More

J Neurol 2018 Dec 5. Epub 2018 Dec 5.

Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, The Netherlands.

The impact of vibrotactile feedback of the gravity vector, provided by a "balance" belt worn around the waist, was evaluated in 39 patients with a severe bilateral vestibular loss, confirmed by extensive laboratory testing and suffering from a low quality of life, mainly due to imbalance. The mobility and balance score (MBS) of all patients prior to the use of the belt was equal or less than 5 out of a scale of 10. Thirty-one out of the 39 patients experienced the effect of the belt on their balance and mobility as positive in a preselection trial of 2 h in the hospital. Read More

Front Oncol 2018 21;8:532. Epub 2018 Nov 21.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide with a poor prognosis and high mortality. More than two-thirds of HNSCC patients still have no effective control of clinical progression, and the five-year survival rate is < 50%. Moreover, patients with platinum-refractory HNSCC have a median survival of < 6 months. Read More

Cureus 2018 Sep 28;10(9):e3381. Epub 2018 Sep 28.

Department of Internal Medicine, Hospital Teodoro Maldonado Carbo / Universidad Catolica De Santiago De Guayaquil, Guayaquil, ECU.

Chordomas are rare, slow-growing, and locally aggressive malignant neoplasms derived from primitive notochord remnants. The chondroid variety represents 14% of all chordomas mainly developing in the spheno-occipital region and presenting between the third and fifth decades of life. When developing intracranially, symptoms can range from headaches and neck pain to cranial nerve neuropathies and facial numbness. Read More

F1000Res 2018 21;7. Epub 2018 Nov 21.

Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Over the last few years, certain areas in the management nasopharyngeal carcinoma (NPC) that have an impact on the care of these patients have evolved, particularly with regard to liquid biopsies, minimally invasive surgery, and advances in chemotherapy and immunotherapy. Beyond its proven role in the diagnostics, surveillance, and treatment of NPC, liquid biopsy with plasma Epstein-Barr virus DNA in the screening of high-risk populations for NPC is strongly supported by recent evidence. Surgery of the nasopharynx is reserved for locally recurrent NPC, and in recent years there have been great strides in minimally invasive techniques with survival rates similar to those of open techniques in treating NPC. Read More

Clin Transl Allergy 2018 29;8:50. Epub 2018 Nov 29.

1Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080 Guangdong China.

Background: Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP.

Methods: Samples were collected from 30 NP patients and 16 control subjects recruited prospectively. Read More

J Cancer 2018 31;9(23):4430-4439. Epub 2018 Oct 31.

Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.

Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis. However, the impact of TFF3 on patients' clinicopathological characteristics and underlying mechanisms remain unknown in papillary thyroid carcinoma (PTC). Read More

J Cancer 2018 20;9(22):4234-4241. Epub 2018 Oct 20.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p. Read More

Case Rep Neurol 2018 Sep-Dec;10(3):314-321. Epub 2018 Nov 14.

Department of Neurosurgery, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Republic of Korea.

The authors here report a case of stent-assisted angioplasty under intravascular ultrasound (IVUS) guidance for the treatment of spontaneous bilateral extracranial vertebral artery (VA) dissection. A 47-year-old woman presented with spontaneous severe posterior neck pain. Examinations revealed bilateral extracranial VA dissection, which was thought to be the reason for her symptom. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):742-750. Epub 2018 Nov 12.

Hematology/Oncology, University of Texas Medical Branch, Galveston, Texas, USA.

Background: Esophageal cancer (EC) with unexpected metastasis (UM) to unusual sites have been increasingly reported. EC with metastasis in general has a very high mortality and morbidity rate, and those with UM to unusual sites present another specific field that needs to be further studied in order to understand and manage the presentation. An extensive systematic review was recently completed regarding this field which identified characteristics and findings concerning patients with EC with UM sites. Read More

Case Rep Oncol 2018 Sep-Dec;11(3):735-741. Epub 2018 Nov 12.

Division of Medical Oncology/Hematology, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

Standard therapy for radioactive iodine (RAI)-refractory differentiated thyroid cancer (DTC) is multi-targeted kinase inhibitors (m-TKIs), represented by sorafenib and lenvatinib. One of the main target molecules of m-TKIs is vascular endothelial growth factor receptor (VEGF-R). m-TKIs are known to cause adverse reactions such as hypertension and proteinuria as a class effect. Read More