Search Our Scientific Publications & Authors

Ann Nucl Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Head and Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: Medullary thyroid cancer (MTC) arises from neuroendocrine C cells of the thyroid. There is no single diagnostic imaging method that can reveal all MTC recurrences or metastases. Ga-DOTATATE is an alternative PET radiotracer that showed acceptable efficacy in the detection of MTC. Read More

Otolaryngol Head Neck Surg 2020 Jun 30:194599820932869. Epub 2020 Jun 30.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Objective: To evaluate expression of potential molecular imaging targets epidermal growth factor receptor (EGFR), glycoprotein nonmetastatic melanoma protein B (GPNMB), and vascular endothelial growth factor (VEGF) in lymph nodes (LNs) with or without head and neck squamous cell carcinoma (HNSCC) metastases after (chemo)radiation.

Study Design: Retrospective study comparing receptor expression in paired lymph nodes after initial treatment.

Setting: A tertiary referral hospital. Read More

Endokrynol Pol 2020 Jun 29. Epub 2020 Jun 29.

Pathology Department, District Hospital, Arkonska 4, 71-455 Szczecin, Poland.

Background: The regional lymph node metastases of papillary thyroid carcinoma are very common. Subclinical neck lymphatic malignancy of the undiagnosed papillary carcinoma can be found by chance at autopsy or intravitally, especially during neck imaging scrutiny for other reasons. And cervical lymph node metastasis as the initial manifestation of occult papillary thyroid carcinoma is very rare phenomenon. Read More

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral and Maxillofacial Surgery, University Hospital Ostrava, Czech Republic.

Introduction: In patients with squamous cell carcinoma of the orofacial area, the presence of cervical metastases represents a single most significant prognostic factor. This fact underlines the importance of thorough examination of the cervical lymph nodes for potential tumor involvement. To verify this, the most common investigative methods are physical examination (PE), sonography (US) and computed tomography (CT), which have also been used to assess the stage of the disease in the patients in our research. Read More

World J Otorhinolaryngol Head Neck Surg 2020 Jun 18;6(2):125-131. Epub 2020 Apr 18.

Department of Otolaryngology- Head and Neck Surgery, Rabin Medical Center, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Chordomas are locally invasive neoplasms, arising from notochordal remnants and can appear anywhere along the axial skeleton. Local recurrences are common, and distant metastases may occur years after the initial presentation.

Methods: Literature review of current treatment strategies for chordomas of the skull base. Read More

Surgery 2020 Jun 24. Epub 2020 Jun 24.

UOC Chirurgia Endocrina e Metabolica-Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Dipartimento Universitario di Medicina e Chirurgia Traslazionale-Università Cattolica del Sacro Cuore, Rome, Italy.

Background: Thyroid lobectomy is the preferred option for small, unifocal papillary thyroid carcinoma. Involvement of the central neck lymph nodes is an indication for total thyroidectomy plus central neck dissection. We aimed to verify if frozen section examination of ipsilateral central neck nodes can identify the subgroup of patients scheduled for thyroid lobectomy intraoperatively who could benefit of more extensive initial operative treatment. Read More

Auris Nasus Larynx 2020 Jun 23. Epub 2020 Jun 23.

Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611 Tokyo, Japan.

Objective: Bone turnover suppression agents are widely used for prophylaxis of bone metastases from cancer and osteoporosis; the occurrence of their side effect, antiresorptive agent-related osteonecrosis of the jaw (ARONJ), has been increasing. We investigated the relationships between opacification in the nasal sinuses, rhinosinusitis, and ARONJ based on data obtained from oral surgeons.

Methods: We examined 132 patients who had been clinically diagnosed with ARONJ based on clinical observations; all patients had undergone treatment at the Departments of Otorhinolaryngology and Oral Surgery. Read More

Br J Oral Maxillofac Surg 2020 Jun 22. Epub 2020 Jun 22.

Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital, Seoul, Republic of Korea; Dental Research Institute, Seoul National University, Seoul, Republic of Korea; Clinical Trial Center and Oral Cancer Center, Seoul National University Dental Hospital, Seoul, Republic of Korea. Electronic address:

Because of the poor prognosis and of oral mucosal melanoma, and patients' short survival, large, randomised, clinical studies are difficult. We have investigated its demographic characteristics and analysed the effect of treatment, resection margins, and metastases on survival. We recorded age, sex, site of primary tumour, and types of treatment, survival, and metastases in 74 patients treated at the Department of Oral and Maxillofacial Surgery, Seoul National University Dental Hospital. Read More

Surg Case Rep 2020 Jun 22;6(1):145. Epub 2020 Jun 22.

Department of Breast and Endocrine Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Background: Parathyroid carcinoma as a cause of primary hyperparathyroidism in children is extremely rare. We report a case of parathyroid carcinoma which occurred in a 13-year-old girl who survived for more than 45 years after the first operation.

Case Presentation: A woman was admitted to our hospital for the treatment of recurrent parathyroid carcinoma in the neck. Read More

Acta Neurochir (Wien) 2020 Jun 23. Epub 2020 Jun 23.

Department of Neurological Surgery, The Wexner Medical Center, James Cancer Center, The Ohio State University, 410 W 10th Ave, 1014 N Doan Hall, Columbus, OH, 43210-1267, USA.

Background: Metastatic cervical spine disease can cause compression fractures, cervical spine instability, and pain. Vertebroplasty can stabilize a fracture, reduce the pain associated with a compression fracture, prevent or stop the progression of a fracture, thus avoiding cervical spine fixation, and decreased mobility. Transoral C2 vertebroplasty is less invasive than open fusion surgery, but it poses its own risk of infection and cement leak in this highly sensitive area. Read More

Crit Rev Oncol Hematol 2020 May 30;153:102984. Epub 2020 May 30.

Department of Oral and Maxillofacial Surgery, Prince Phillip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong Special Administrative Region. Electronic address:

Background: The most effective regimen is unclear for patients with recurrent or metastatic head and neck squamous cell carcinomas (R/M HNSCC). We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating only systemic therapy for R/M HNSCC.

Methods: This systematic review followed PRISMA and the Cochrane Collaboration Handbook for Systematic Reviews of Interventions. Read More

Clin Otolaryngol 2020 Jun 22. Epub 2020 Jun 22.

Service d'ORL et Chirurgie Cervico-Faciale, Centre Hospitalier Universitaire La Conception, 147 Boulevard Baille, 13005, Marseille, France.

Objectives: The aim of this study was to identify prognostic factors affecting the survival of the low grade Mucoepidermoid carcinomas (MEC) without clinical-radiological lymph node involvement (cN0) at the time of the initial work-up and to determinate the therapeutic strategy for the neck dissection MATERIALS AND METHODS: One hundred and fifty two patients with cN0 low-grade MEC of salivary glands, were prospectively included in the Réseau d'Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Neck Tumors) database between 2009 and 2015. Overall survival, disease-free survival and the rate of nodal recurrence were evaluated.

Results: Seventy five patients had a clinical stage I (49. Read More

J Craniofac Surg 2020 Jun 15. Epub 2020 Jun 15.

Department of Otolaryngology, Head and Neck Surgery, Tufts Medical Center, Boston, MA.

Introduction: Breast cancer is one of the most common cancers in women. Metastatic disease is a leading cause of morbidity and mortality. It frequently metastasizes to bone, lungs, regional lymph nodes, liver and brain. Read More

J Craniofac Surg 2020 Jun 18. Epub 2020 Jun 18.

Pathology Department, IRCCS Regina Elena National Cancer Institute, Rome.

Localization of metastases into the parotid gland is a very uncommon event. Usually they arise from primary tumors located in the head and neck, mainly melanoma or epidermoid carcinoma of the skin, while other histotypes, from others anatomical districts, hardly have a metastatic spread to the parotid. Myxoid Liposarcoma (MLS) is a rare malignant tumor of the soft tissue that mainly occurs in the extremities, representing the second most common subtype of liposarcoma. Read More

J Vis Exp 2020 Jun 6(160). Epub 2020 Jun 6.

Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam;

Radical resection margins, resection of Gerota's (perirenal) fascia, and adequate lymph node dissection are crucial for an adequate oncological resection of left-sided pancreatic cancer. Several surgical techniques have been described in recent years, but few were specifically designed for minimally invasive approaches. This study describes and demonstrates a standardized and reproducible technique for an adequate oncological resection of pancreatic cancer: laparoscopic radical left pancreatectomy (LRLP). Read More

Oncol Lett 2020 Jul 14;20(1):907-913. Epub 2020 May 14.

Department of Ultrasound, Beijing Geriatric Hospital, Beijing 100095, P.R. China.

The present study aimed to investigate the expression of long non-coding HOX transcript antisense RNA (lncRNA-HOTAIR) in the serum of patients with lymph node metastasis of papillary thyroid carcinoma (PTC) and the underlying mechanism. A total of 89 patients with PTC at Beijing Geriatric Hospital were recruited in this study. Based on the results of color Doppler ultrasound examination, the patients were evaluated for cervical lymph node metastases, and were thereby divided into a metastasis-negative group and a metastasis-positive group. Read More

ANZ J Surg 2020 Jun 21. Epub 2020 Jun 21.

Department of Otolaryngology-Head and Neck Surgery, St Vincent's Hospital, Sydney, New South Wales, Australia.

Background: Fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) is well validated in the staging of pre-treatment head and neck squamous cell carcinoma (HNSCC), although the impact of human papilloma virus (HPV) status and node size on accuracy remains unclear. The aim of this study was to assess the diagnostic accuracy of PET/CT based on HPV status and node size and determine the effects of maximum standardized uptake value thresholds on sensitivity, specificity and positive predictive value.

Methods: A total of 38 patients with primary HNSCC were recruited. Read More

Oncol Res Treat 2020 Jun 19:1-7. Epub 2020 Jun 19.

Department of Otorhinolaryngology and Maxillofacial Surgery, Maribor University Clinical Center, Maribor, Slovenia.

Purpose: Neck metastases in breast carcinoma are relatively rare and patients show poor survival rates. A controversy exists over whether neck metastases can be treated as distant or loco-regional metastases. The literature concerning the distribution of metastases in the neck is lacking, as well as data about whether metastases in the higher neck regions cause poorer survival than those in the supraclavicular fossa. Read More

Ann Dermatol Venereol 2020 Jun 17. Epub 2020 Jun 17.

Groupe hospitalier Necker-Enfants malades, service d'anatomopathologie, AP-HP, Paris, France.

Introduction: Neonatal and infantile malignant melanoma is rare. It may be difficult to diagnose and often carries a poor prognosis.

Material And Methods: We decided to review the data on congenital, neonatal and infantile malignant melanomas in order to understand their presentation (clinical, histological, molecular), diagnosis, management and outcomes. Read More

Int J Surg Case Rep 2020 Jun 13;72:322-325. Epub 2020 Jun 13.

Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service - Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Electronic address:

Introduction: Papillary thyroid carcinoma (PTC) is the most common carcinoma to occur in childhood with a peak incidence between 11-17 years, and typically presents with advanced locoregional disease. Pulmonary metastases are seen in up to 46% of cases and should enter the differential diagnosis of miliary nodules seen on chest roentgenogram, even in regions where tuberculosis is endemic.

Presentation Of Case: An 11-year-old male presented with a short history of cough, shortness of breath and constitutional symptoms. Read More

Thorac Cardiovasc Surg 2020 Jun 19. Epub 2020 Jun 19.

Department of Thoracic Surgery, University Hospital Erlangen, Erlangen, Germany.

Background:  There is no consensus on the value of pulmonary metastasectomy (PM) for head and neck cancer (HNC). The aim of our single-institution study was to evaluate outcomes and to examine factors influencing 5-year survival of patients undergoing resections for HNC lung metastases.

Methods:  All HNC patients undergoing curative-intent PM between January 2008 and December 2018 were retrospectively analyzed. Read More

World J Surg 2020 Jun 18. Epub 2020 Jun 18.

Department of Endocrinology, Ulsan University Hospital, University of Ulsan College of Medicine, 877, Bangeojinsunhwando-ro, Dong-gu, Ulsan, 44033, South Korea.

Background: It is unknown whether familial non-medullary thyroid cancer (FNMTC) has more aggressive clinical features and a worse prognosis than sporadic non-medullary thyroid cancer (SNMTC).

Methods: We retrospectively reviewed 2894 patients with differentiated thyroid cancer who underwent primary thyroidectomy, identified 391 FNMTC cases, and compared the prevalence, surgical extension, and clinicopathologic features of FNMTC and SNMTC.

Results: A family history of thyroid cancer was noted in 391 patients (13. Read More

World J Clin Cases 2020 Jun;8(11):2350-2358

Department of CT/MRI, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China.

Background: A myxofibrosarcoma (MFS) is a malignant fibroblastic tumor that tends to occur in the lower and upper extremities. The reported incidence of head and neck MFSs is extremely rare. We report a 46-year-old male with "a neoplasm in the scalp" who was hospitalized and diagnosed with an MFS (highly malignant with massive necrotic lesions) based on histologic and immunohistochemistry evaluations. Read More

Ann Otol Rhinol Laryngol 2020 Jun 16:3489420934846. Epub 2020 Jun 16.

Commonwealth Health Center, Saipan, Northern Mariana Islands.

Background: Oral cavity carcinomas individually are the fifth-leading cause of overall cancer mortality in the Northern Mariana Islands, which is likely a representative statistic for many other betel-nut-endemic Pacific islands. Factors associated with survival have been minimally evaluated in this region. The purpose of this study is to further characterize oral cavity carcinoma outcomes and associated prognostic factors in the United States commonwealth of the Northern Mariana Islands (CNMI). Read More

Gan To Kagaku Ryoho 2020 Jun;47(6):981-983

Dept. of Surgery, Iwate Medical University.

Ramucirumab(RAM)plus nab-paclitaxel(nab-PTX)therapy is a regimen that is recommended for the second round of chemotherapy in recurrent, progressive gastric cancer. We report the first case of a thoracic aortic dissection developed during RAM plus nab-PTX therapy. A 59-year-old male who had undergone a proximal gastrectomy for esophagogastric junction cancer had a recurrence of cancer 6 years later(metastasis to the para-aortic lymph node and left adrenal gland, local recurrence, and multiple bone metastases). Read More

J Oral Maxillofac Surg 2020 May 13. Epub 2020 May 13.

Department Head and Docent, Department of Plastic Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

Purpose: Studies of the effects of perioperative dexamethasone (DEX) during oncologic surgery are scarce. The first aim of the present study was to clarify whether perioperative DEX affects the short-term mortality in patients with head and neck cancer (HNC). The second aim was to analyze the causes of death and predictors affecting long-term mortality. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Jun 13. Epub 2020 Jun 13.

Department of Otolaryngology Head and Neck Surgery, Galilee Medical Center, affiliated with Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. Electronic address:

Objective: The purpose of our systematic review was to investigate the prevalence of level IV involvement and skip metastases in patients with clinically negative neck (cN0) oral tongue squamous cell carcinoma (OTSCC). The occurrence of occult metastases to lower levels in the neck (levels IV and V) or the development of an erratic distribution of cervical metastases ("skip metastases") that bypass the upper neck levels (levels I to III) and go directly to level IV or V challenges the role of supraomohyoid neck dissection in the treatment of OTSCC; therefore, controversy exists over including level IV cervical nodes during an elective neck dissection of OTSCC.

Study Design: Our search included all studies published from 1989 until January 2018 in the Cochrane Library, PubMed, EMBASE, and Web of Science. Read More

Ann Surg Oncol 2020 Jun 11. Epub 2020 Jun 11.

Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

Background: No adequate biomarker for Merkel cell carcinoma (MCC) has been identified. Serum neuron-specific enolase (NSE) has been tested and is commonly used as a biomarker for several other small cell malignancies. However, the role of NSE in MCC is still unclear. Read More

AACE Clin Case Rep 2020 May-Jun;6(3):e113-e116. Epub 2020 May 11.

Objective: Parathyroid carcinoma (PTC) has a high rate of recurrence, which typically occurs within 5 years of diagnosis involving locoregional sites. Immunosuppressive therapies pose a theoretical increased risk of malignancy. We report an atypical case of PTC recurrence in a patient receiving infliximab therapy for ulcerative colitis (UC). Read More

Br J Oral Maxillofac Surg 2020 Jun 7. Epub 2020 Jun 7.

Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, PO Box 220, FI-00029 Helsinki. Electronic address:

The aim of this retrospective study was to analyse a consecutive series of patients with oral and oropharyngeal carcinoma who had had sentinel lymph node biopsy (SLNB) at our hospital during 2008-2017. A total of 70 patients with clinically and radiologically confirmed primary oral (n=67) or oropharyngeal (n=3) carcinoma, with no signs of metastatic lymph nodes preoperatively (clinically N0) were included. Patients' clinical and personal data, characteristics of the tumours, sentinel lymph node (SLN) status and outcomes were recorded. Read More

Acta Otolaryngol 2020 Jun 10:1-8. Epub 2020 Jun 10.

Department of ORL, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden.

The role of CT scanning at the time of diagnosis for patients with primary cutaneous head and neck melanoma (cHNM) clinically asymptomatic for metastatic disease remains unclear. To determine the positive yield of initial CT scanning before considering sentinel lymph node biopsy (SLNB) staging. A retrospective review was performed on 170 consecutive patients with cHNM referred to a tertiary head and neck academic center for SLNBs from 2014 through 2018. Read More

Braz J Med Biol Res 2020 3;53(7):e9029. Epub 2020 Jun 3.

Department of Otorhinolaryngology and Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

This study examined the expression and potential mechanism of microRNA (miRNA)-424-5p in nasopharyngeal carcinoma (NPC). NPC tissues were collected from 40 patients who were enrolled in the study, and skin samples were collected from 26 healthy subjects during plastic surgery as controls. We performed various in vitro assays using miR-424-5p to examine its function in primary NPC-1 cells. Read More

Eur Arch Otorhinolaryngol 2020 Jun 9. Epub 2020 Jun 9.

Department of Nuclear Medicine, Cristo Re Hospital, Rome, Italy.

Purpose: Data from literature show a mean incidence of occult metastases of 33% in early OCSCC. The gold standard for most authors is a selective neck dissection and a routine pathological examination. 60-70% of unnecessary neck dissections with associated morbidity, can be avoided by using SNB. Read More

J Craniomaxillofac Surg 2020 Jul 4;48(7):672-679. Epub 2020 Jun 4.

Maxillofacial/Head and Neck Surgeon, Department of Oral and Maxillofacial Surgery, Head and Neck Unit, Royal Derby Hospital, UK.

There is currently no consensus as to the ideal timing, frequency and modality of imaging for follow up of head and neck cancer patients. The aim of this study was to analyze the diagnostic accuracy of PET-CT versus MRI, and imaging at 3 versus 6 months for follow up of head and neck cancer patients treated with curative intent with no clinical signs of treatment failure.

Materials And Methods: A retrospective study was performed for all head and neck cancers treated with curative intent at the Royal Derby Hospital. Read More

Oral Oncol 2020 Jun 3;108:104822. Epub 2020 Jun 3.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

Objective: Prognostic factors specific to surgically managed human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC) are not fully understood. Medical co-morbidities may have an impact on survival after surgical treatment. We aimed to identify co-morbidities associated with distant metastases-free survival (DMFS) and cancer-specific survival (CSS) in HPV(+)OPSCCs. Read More

BMC Cancer 2020 Jun 5;20(1):519. Epub 2020 Jun 5.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression in a large cohort of primary, recurrent and metastasized AdCC of the head and neck. Read More

Cancer Manag Res 2020 13;12:3371-3378. Epub 2020 May 13.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Background: Therapeutic lateral neck dissection (LND) is recommended in papillary thyroid carcinoma (PTC) patients with clinically lateral lymph node metastasis (LLNM), whether underwent level V LND remains controversial for lacking of sensitive predicting system. mutation is associated with aggressive tumor behavior, recurrence, and disease-specific mortality of PTC. However, the relationship between mutation and level V LNM is unclear. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2020 May 31. Epub 2020 May 31.

Clinical Research Division, National Cancer Institute of Brazil, Rio de Janeiro, Brazil (INCA). Electronic address:

Objective: The aim of this systematic review was to describe the epidemiology, diagnostic criteria, differential diagnosis, treatment, prognostic factors, and treatment outcomes of secretory carcinoma.

Study Design: A comprehensive search of Lilacs, PubMed, Science Direct, and Web of Science databases was conducted to identify all case reports, letter to the editor, and histopathologic reclassifications regarding salivary gland secretory carcinoma published in English, Spanish, French, and Portuguese.

Results: The final analysis included 119 studies, which totaled 642 secretory carcinoma diagnoses, with 239 case reports and 403 diagnostic reclassifications, mostly in the United States. Read More

Eur Arch Otorhinolaryngol 2020 Jun 2. Epub 2020 Jun 2.

Department of Otolaryngology, Head and Neck and Maxillofacial Surgery, The Interdisciplinary Center for Head and Neck Surgical Oncology, Tel-Aviv Sourasky Medical Center, 6 Weitzman Street, 6423906, Tel-Aviv, Israel.

Objective: Lateral and central compartments cervical lymph nodes metastases are common among patients with papillary thyroid carcinoma (PTC). Elective level VI neck dissection during thyroidectomy and lateral neck dissection (LND) for the treatment of PTC with lateral compartment lymph node metastases is controversial because of the uncertain benefit in clinical outcomes and increased risks of surgical morbidity. We aimed to determine the potential benefit of elective level VI neck dissection in patients with cN1 papillary thyroid carcinoma (PTC) by investigating the rate and pattern of locoregional recurrence in PTC patients who underwent total thyroidectomy and therapeutic lateral node dissection (LND; levels II-IV) without elective level VI dissection. Read More

Anticancer Res 2020 Jun;40(6):3559-3564

Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Gunma, Japan

Background/aim: We aimed to elucidate the clinical implication of the epithelial-mesenchymal plasticity of circulating tumor cells (CTCs) in patients with head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: CTCs isolated from 44 patients with non-recurrent/metastatic HNSCC and 42 with recurrent/metastatic (R/M) HNSCC were classified into four epithelial-mesenchymal transition (EMT) statuses based on the expression of epithelial (keratin 19) and mesenchymal (vimentin) markers and the relationships between EMT status in CTCs and clinical factors were investigated.

Results: EM CTC phenotype was more frequent in patients without recurrence/metastasis (p=0. Read More

Head Neck 2020 Jun 2. Epub 2020 Jun 2.

Head and Neck Tumor Center, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Pathologic extranodal extension (pENE) impacts treatment planning and is an important prognostic indicator for patients with head and neck squamous cell carcinoma (HNSCC). Computed tomography (CT) is a commonly used modality for assessment of radiographic ENE (rENE). To determine the predictive value of CT-identified rENE in predicting pENE, we performed a systematic review through a search of 4 databases (PubMed, Scopus, Cochrane, and OVID). Read More

Hinyokika Kiyo 2020 Apr;66(4):115-119

The Department of Oncologic Pathology, Mie University Graduate School of Medicine.

A 67-year-old female presented for evaluation of a left inguinal mass. Contrast-enhanced computed tomography revealed a tumor surrounding the urethra. Magnetic resonance imaging showed that the tumor had invaded the bladder neck on the anterior aspect of the urethra. Read More

SAGE Open Med Case Rep 2020 6;8:2050313X20917846. Epub 2020 May 6.

General Surgery Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Squamous cell carcinoma and papillary thyroid carcinoma simultaneously spreading from the thyroglossal duct remnant (TGDR) is a very rare event. The recognition of this condition allows a correct management and treatment, offering the best chances of cure to the patient. We describe the case of a 42-year-old woman who noticed a right-sided lump in her neck. Read More

Surgery 2020 May 28. Epub 2020 May 28.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Prior studies demonstrated that older adults tend to undergo less surgery for thyroid cancer. Our objective was to use a discrete choice experiment to identify factors influencing surgical decision-making for older adults with thyroid cancer.

Methods: Active and candidate members of the American Association of Endocrine Surgeons were invited to participate in a web-based survey. Read More

Oncogenesis 2020 May 28;9(5):54. Epub 2020 May 28.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.

Tumor cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect, but the involvement of Warburg effect in liver cancer cell metastasis is not well understood. In present study, our results indicate a positive correlation between glucose metabolism level and metastatic potential of hepatocellular carcinoma (HCC). We also observed that a long noncoding RNA-SOX2OT (lncRNA-SOX2OT) can not only increase the metastatic potential of HCC but also promote a pyruvate kinase M2 (PKM2)-mediated activation of glucose metabolism. Read More

Endocr J 2020 May 27. Epub 2020 May 27.

Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-Cho, Chuo-Ku, Kobe 650-0017, Japan.

To clarify the patterns of the recurrence and to assess the oncological and functional outcomes after salvage surgery for the patients with structural local recurrence of papillary thyroid cancer (PTC), twenty-five patients who underwent salvage surgery for structural local recurrence of PTC were retrospectively reviewed. Structural recurrences were observed in the tracheal lumen in 5 patients, intraluminal or intramuscular esophagus in 5 patients, trachea, and cricoid cartilage in 9 patients, cricoid and thyroid cartilage in 2 patients, intra-lumen of the larynx in 1 patient and soft tissue around thyroid in 3 patients, respectively. Although all local disease was resected with macroscopically negative margin, 10 patients diagnosed as microscopically positive margin. Read More

Mod Pathol 2020 May 26. Epub 2020 May 26.

Kinghorn Cancer Centre and Garvan Institute of Medical Research, Sydney, NSW, Australia.

Salivary duct carcinoma (SDCa) is a rare cancer with high rate of metastases and poor survival despite aggressive multimodality treatment. This study analyzes the genetic changes in SDCa, their impact on cancer pathways, and evaluates whether molecular patterns can identify subgroups with distinct clinical characteristics and outcome. Clinicopathologic details and tissue samples from 66 patients (48 males, 18 females) treated between 1995 and 2018 were obtained from multiple institutions. Read More

Case Rep Endocrinol 2020 11;2020:6438352. Epub 2020 May 11.

Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan.

A 75-year-old woman visited a nearby clinic with complaints of right clavicle discomfort, and she underwent diagnostic thoracoscopic lung biopsy, being diagnosed with lung metastasis and a right-upper mediastinal mass. The superior mediastinum mass was extrapulmonary and covered by the pleura, and it was not biopsied. Papillary thyroid carcinoma was diagnosed following biopsy of the lung metastasis. Read More

Acta Cytol 2020 May 26:1-9. Epub 2020 May 26.

Department of Pathology and Laboratory Medicine, University of California, Irvine, California, USA.

Background: Primary synovial sarcoma (SS) of the thyroid (PSST) is extremely rare. Its differential diagnosis from other neoplasms is essential since it has different management protocols and prognosis.

Case: A 26-year-old man with a 4. Read More

Sci Rep 2020 May 25;10(1):8615. Epub 2020 May 25.

Rudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, University of Leipzig, Leipzig, Germany.

The Special AT-rich sequence binding protein 1 (SATB1) is a genome organizer protein that controls gene expression of numerous genes by regulating chromatin architecture and targeting chromatin-remodeling/-modifying enzymes onto specific chromatin regions. SATB1 is overexpressed in various tumors. In head and neck squamous cell carcinoma (HNSCC), SATB1 upregulation is correlated with TNM classification, metastasis, poor prognosis and reduced overall survival. Read More