1,989 results match your criteria Neck Cervical Metastases Detection

Advances in Clinical Oncology Research on Tc-3PRGD2 SPECT Imaging.

Liming Xiao Jun Xin

Front Oncol 2022 31;12:898764. Epub 2022 May 31.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China.

The integrin alpha(α)v beta(β)3 receptor is ubiquitous in malignant tumors and has a certain level of specificity for tumors. Technetium-99m hydrazinonicotinamide-dimeric cyclic arginyl-glycyl-aspartic acid peptide with three polyethylene glycol spacers (Tc-3PRGD) can bind specifically to the integrin αvβ3 receptor with high selectivity and strong affinity. Thus, it can specifically mark tumors and regions with angiogenesis for tumor detection and be used in single-photon emission computed tomography (SPECT) imaging. Read More

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A Nomogram for Predicting the Risk of Bone Metastasis in Newly Diagnosed Head and Neck Cancer Patients: A Real-World Data Retrospective Cohort Study From SEER Database.

Front Genet 2022 30;13:865418. Epub 2022 May 30.

Department of Orthopedics, West China Hospital of Sichuan University, Chengdu, China.

Bone metastasis (BM) is one of the typical metastatic types of head and neck cancer (HNC). The occurrence of BM prevents the HNC patients from obtaining a long survival period. Early assessment of the possibility of BM could bring more therapy options for HNC patients, as well as a longer overall survival time. Read More

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Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma.

Sci Rep 2022 Jun 4;12(1):9316. Epub 2022 Jun 4.

Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Early recurrence detection of head and neck squamous cell carcinoma (HNSCC) is important for improving prognosis. Recently, circulating tumor DNA (ctDNA) has been reported to be useful in early detection or treatment response determination in various carcinomas. This study aimed to identify the utility of ctDNA for predicting recurrent metastasis in patients with HNSCC. Read More

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SCC Antigen Concentrations in Fine-Needle Aspiration Samples to Detect Cervical Lymph Node Metastases: A Prospective Analysis.

Otolaryngol Head Neck Surg 2022 May 31:1945998221102870. Epub 2022 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Objective: To determine the diagnostic value of measuring squamous cell carcinoma antigen (SCC-Ag) and cancer antigen 15-3 (CA15-3) concentrations in fine-needle aspiration (FNA) samples for the detection of squamous cell carcinoma (SCC) metastases in cervical lymph nodes.

Study Design: A prospective study with patients consecutively included between November 2018 and May 2021.

Setting: A tertiary head and neck oncologic center. Read More

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Role of Texture Analysis in Oropharyngeal Carcinoma: A Systematic Review of the Literature.

Cancers (Basel) 2022 May 16;14(10). Epub 2022 May 16.

Department of Radiology, University of Florence-Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy.

Human papilloma virus infection (HPV) is associated with the development of lingual and palatine tonsil carcinomas. Diagnosing, differentiating HPV-positive from HPV-negative cancers, and assessing the presence of lymph node metastases or recurrences by the visual interpretation of images is not easy. Texture analysis can provide structural information not perceptible to human eyes. Read More

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Circulating tumor cells as a predictor for poor prognostic factors and overall survival in treatment naïve oral squamous cell carcinoma patients.

Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Jul 6;134(1):73-83. Epub 2022 Mar 6.

Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Mumbai, India; Homi Bhabha National Institute, Mumbai, India. Electronic address:

Objective: The aim of this study was to investigate the presence of circulating tumor cells (CTCs) and their correlation with prognostic factors and clinical outcomes in treatment-naive patients with oral squamous cell carcinoma.

Study Design: CTCs were isolated using OncoDiscover technique from presurgically obtained peripheral blood of 152 patients with treatment naïve oral squamous cell carcinoma. Sensitivity analysis was performed by including 40 healthy controls. Read More

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Epigenetic Deregulation of Protein Tyrosine Kinase 6 Promotes Carcinogenesis of Oral Squamous Cell Carcinoma.

Int J Mol Sci 2022 Apr 19;23(9). Epub 2022 Apr 19.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 701401, Taiwan.

Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers and causes considerable morbidity and mortality. Epigenetic deregulation is a common mechanism underlying carcinogenesis. DNA methylation deregulation is the epigenetic change observed during the transformation of normal cells to precancerous and eventually cancer cells. Read More

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Ga Fibroblast Activation Protein Inhibitor PET/CT in the Detection of Metastatic Thyroid Cancer: Comparison with F-FDG PET/CT.

Radiology 2022 May 10:212430. Epub 2022 May 10.

From the Department of Nuclear Medicine & Minnan PET Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Background Gallium 68 (Ga)-labeled fibroblast activation protein inhibitor (FAPI) has been proposed as a potential radiotracer for visualizing cancerous lesions, but its utility for identifying metastatic differentiated thyroid cancer (DTC) is not well established in the literature. Purpose To evaluate the clinical utility of Ga-FAPI PET/CT for detecting metastatic DTC and to compare the results with those of fluorine 18 (F) fluorodeoxyglucose (FDG) PET/CT. Materials and Methods Participants with clinically suspected or confirmed metastatic DTC were prospectively enrolled and underwent paired Ga-FAPI and F-FDG PET/CT from May to August 2020. Read More

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The impact of multimodality integrated positron emission tomography-computed tomography on improving the staging and management of head and neck malignancy: a cross- sectional study.

Sao Paulo Med J 2022 May-Jun;140(3):454-462

MD. Professor, Department of Imaging, Nuclear Diagnostic Imaging Centre, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang, Selangor, Malaysia.

Background: Clinical assessment of head and neck cancers is highly challenging owing to the complexity of regional anatomy and wide range of lesions. The diagnostic evaluation includes detailed physical examination, biopsy and imaging modalities for disease extent and staging. Appropriate imaging is done to enable determination of precise tumor extent and involvement of lymph nodes, and detection of distant metastases and second primary tumors. Read More

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Prospective study on the clinical relevance of F-DOPA positron emission tomography/computed tomography in patients with medullary thyroid carcinoma.

Endocrine 2022 Apr 30. Epub 2022 Apr 30.

Molecular Imaging and Metabolic Therapy Section. Imaging Department, University Hospital CEMIC, Galván 4102. CP 1414, Ciudad Autónoma de Buenos Aires, Argentina.

Purpose: F-DOPA Positron Emission Tomography/Computed Tomography (F-DOPA PET/CT) is a sensitive functional imaging method (65-75%) for detecting disease localization in medullary thyroid cancer (MTC). We aimed: (i) to assess the clinical usefulness of F-DOPA PET/CT in patients with MTC and elevated calcitonin (Ctn) and CEA levels and, (ii) to evaluate changes in disease management secondary to the findings encountered with this methodology.

Methods: Thirty-six patients with MTC and Ctn levels ≥150 pg/ml were prospectively included. Read More

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Anaplasia and multinucleation in metastases of oropharyngeal squamous cell carcinoma is associated with poorer outcomes.

J Am Soc Cytopathol 2022 Jul-Aug;11(4):201-209. Epub 2022 Apr 2.

Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern Memorial Hospital, Chicago, Illinois.

Introduction: The presence of tumor cell anaplasia and multinucleation (A/M) in oropharyngeal squamous cell carcinoma (OPSCC) has recently been found to be associated with increased disease recurrence and poorer disease-specific survival, regardless of human papillomavirus status. We studied the detection of A/M in cytology specimens.

Materials And Methods: We performed a comprehensive data search for all patients with OPSCC diagnosed and treated at Northwestern Memorial Hospital between January 2013 and April 2020. Read More

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Coherence controlled holographic microscopy - a tool for detection of new biomarkers of head and neck squamous cell carcinoma.

Klin Onkol 2022 ;35(2):128-131

Background: Squamous cell carcinoma of the head and neck is characterized by local invasiveness and metastases to regional lymph nodes. In 60% of cases, these tumours are dia-gnosed at an advanced stage, and the prognosis is unfavorable. One of the important factors of local, hematogenous or lymphogenic spread of the tumour in the human body is tumour cells migration ability. Read More

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A rare case of follicular thyroid carcinoma metastasis to the sacral region: A case report with literature review.

Int J Surg Case Rep 2022 May 29;94:107001. Epub 2022 Mar 29.

ENT Head and Neck Surgery Department, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco.

Introduction: Follicular thyroid carcinoma (FTC) is the second most common thyroid cancer subtype after papillary thyroid cancer (PTC), and it accounts for approximately 10% of all thyroid cancers, the incidence of distant metastasis in FTC has been reported to be 6-20%, bones and lungs are the most frequent sites of distant metastases. Most occult thyroid carcinomas are papillary carcinoma.

Case Presentation: We describe an extremely rare case of a 74-year-old woman who had a history of right thyroid lobectomy 20 years ago, was referred to our hospital for metastatic thyroid follicular carcinoma to the sacral region confirmed by the biopsy of the sacral mass. Read More

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Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection.

Eur J Nucl Med Mol Imaging 2022 Apr 7. Epub 2022 Apr 7.

Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713, GZ, the Netherlands.

Purpose: Patients undergoing prophylactic central compartment dissection (PCLND) for papillary thyroid cancer (PTC) are often overtreated. This study aimed to determine if molecular fluorescence-guided imaging (MFGI) and spectroscopy can be useful for detecting PTC nodal metastases (NM) and to identify negative central compartments intraoperatively.

Methods: We used a data-driven prioritization strategy based on transcriptomic profiles of 97 primary PTCs and 80 normal thyroid tissues (NTT) to identify tumor-specific antigens for a clinically available near-infrared fluorescent tracer. Read More

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Early detection of isolated pleural metastasis from carcinoma pyriform fossa: Can it be steered away from doom?

J Cancer Res Ther 2022 Jan-Mar;18(1):280-281

Department of Radiation Oncology, Christian Medical College and Hospital, Ludhiana, Punjab, India.

Isolated pleural metastasis from carcinoma of the pyriform fossa is a rare phenomenon. Literature search revealed pleural metastasis from head-and-neck cancer is in itself rare and carries a grave prognosis. Isolated pleural metastasis with local control in the primary and regional site with no other documented distant metastatic disease is again rarely encountered. Read More

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Application of One-Step Nucleic Acid Amplification (OSNA) in different cancer entities and usefulness in prostate cancer: a systematic review.

BMC Cancer 2022 Apr 2;22(1):357. Epub 2022 Apr 2.

Urology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Background: Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique remain the gold standard for the evaluation of LN metastases despite some limitations, especially low sensitivity in detecting an accurate tumour burden within the LN, as well as a subjective and time-consuming result. One-step nucleic acid amplification (OSNA) quantifies mRNA copies of cytokeratin 19 (CK19) in a fast, objective, automated, and reproducible way, raising a general interest to explore its utility for lymphatic metastasis identification in different malignancies. Read More

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Accurate preoperative staging with [Ga]Ga-FAPI PET/CT for patients with oral squamous cell carcinoma: a comparison to 2-[F]FDG PET/CT.

Eur Radiol 2022 Mar 30. Epub 2022 Mar 30.

Department of Nuclear Medicine, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou, 350005, China.

Objective: To evaluate the potential value of [Ga]Ga-labelled fibroblast activation protein inhibitor ([Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) in preoperative staging for patients with oral squamous cell carcinoma (OSCC) as compared to 2-[F]fluoro-2-deoxy-D-glucose (2-[F]FDG) PET/CT.

Methods: Thirty-six treatment-naïve patients with OSCC who underwent 2-[F]FDG and [Ga]Ga-FAPI PET/CT for preoperative staging were enrolled. The maximum standardised uptake value (SUV) of the primary tumour and suspected cervical metastatic lymph nodes, and the tumour-to-background ratio (TBR) of the primary tumour, were measured. Read More

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Role and Extent of Neck Dissection for Neck Lymph Node Metastases in Differentiated Thyroid Cancers.

Sisli Etfal Hastan Tip Bul 2021 29;55(4):438-449. Epub 2021 Dec 29.

Department of General Surgery, Division of Endocrine Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Differentiated thyroid cancers (DTC) consist of 95% of thyroid tumors and include papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), and Hurthle cell thyroid cancer (HTC). Rates of lymph node metastases are different depending on histologic subtypes and <5% in FTC and between 5% and 13% in HTC. Lymph node metastasis is more frequent in PTC and while rate of clinical metastasis can be seen approximately 30% rate of routine micrometastasis can be seen up to 80%. Read More

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December 2021

Radiologic-pathologic correlation of major versus minor extranodal extension in oral cavity cancer.

Head Neck 2022 06 22;44(6):1422-1429. Epub 2022 Mar 22.

Department of Otolaryngology-Head and Neck Surgery/Surgical Oncology, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.

Background: To evaluate the diagnostic performance of radiologic extranodal extension (rENE) in predicting major (>2 mm) and minor (≤2 mm) pathologic ENE (pENE).

Methods: All oral cavity squamous cell carcinoma patients who underwent neck dissection with pathological nodal disease (pN+) between 2010 and 2015 were reviewed. Preoperative computed tomography and/or magnetic resonance imaging were reviewed by two head and neck neuroradiologists. Read More

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Does Sentinel Lymph Node Biopsy Accurately Stage the Clinically Negative Neck in Early Oral Cavity Squamous Cell Carcinoma?

J Oral Maxillofac Surg 2022 Jun 18;80(6):1134-1142. Epub 2022 Feb 18.

Associate Professor, Head and Neck Cancer Service, Crown Princess Mary Cancer Centre, Westmead Hospital, Sydney, New South Wales, Australia; Associate Professor, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

Purpose: Sentinel lymph node biopsy (SLNB) is being increasingly used worldwide as a minimally invasive option to stage the clinically node-negative neck (N0) in patients with early oral cavity squamous cell carcinomas (OCSCC). We performed this trial to assess the reliability and validity of the technique.

Methods: We did this prospective interventional nonrandomized study in patients with early (cT1-T2 OCSCC) and with negative neck. Read More

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[Oncologic follow-up in head and neck cancer patients].

HNO 2022 Apr 17;70(4):317-330. Epub 2022 Mar 17.

Klinik für Hals‑, Nasen‑, Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinikum Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Despite medical treatment according to evidence-based guidelines, approximately 25-30% of all head and neck tumor patients suffer a disease relapse, depending on tumor stage and entity. The primary goal of systematic follow-up examinations is early detection and treatment of recurrent tumors or metachronous secondary tumors, but it also serves to rule out distant metastasis. Secondary goals are the diagnosis and management of treatment-associated side effects to optimize quality of life. Read More

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Antibody mediated cotton-archetypal substrate for enumeration of circulating tumor cells and chemotherapy outcome in 3D tumors.

Lab Chip 2022 04 12;22(8):1519-1530. Epub 2022 Apr 12.

Actorius Innovations and Research, Pune, 411057, India.

Circulating tumor cells (CTCs) are distinct cancer biomarkers established in clinical settings for early cancer detection, metastasis progression, and minimal residual disease (MRD) monitoring. Despite numerous advances, the comprehensive molecular characterization of CTCs is extremely challenging owing to their rarity and heterogeneity. Here, we present a novel cotton microfluidic substrate (CMS) as an innovative biomedical matrix that efficiently isolates CTCs while facilitating CTC expansion to enable a further downstream analysis of these rare cells. Read More

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Transoral robotic surgery for the identification of unknown primary head and neck squamous cell carcinomas: Its effect on the wait and the weight.

Head Neck 2022 05 27;44(5):1206-1212. Epub 2022 Feb 27.

Department Otolaryngology-Head and Neck Surgery, Western University, London, Ontario, Canada.

Background: Neck carcinoma of unknown primary (CUP) is a frequent scenario. Transoral robotic mucosectomies (TORM) of pharynx have increased rate of primary identification, but come with cost of treatment delay.

Methods: We reviewed patients who underwent CUP protocol from 2014 to 2020. Read More

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Reducing the unknowns: A systematic review & meta-analysis of the effectiveness of trans-oral surgical techniques in identifying head and neck primary cancer in carcinoma unknown primary.

Oral Oncol 2022 03 7;126:105748. Epub 2022 Feb 7.

Head & Neck Department, Guy's and St Thomas' NHS Foundation Trust, London, UK; King's College London. Electronic address:

Objectives: The use of transoral robotic surgery (TORS), transoral laser microsurgery (TLM) and more recently reported transoral endoscopic electrocautery (TOEC) in identifying the primary cancer in head and neck Carcinoma Unknown Primary (CUP) patients have gained popularity. This review aims to assess the effectiveness of TORS, TLM and TOEC.

Materials & Methods: A systematic review and meta-analysis was carried out. Read More

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Curative intent Stereotactic Ablative Radiation Therapy (SABR) for treatment of lung oligometastases from head and neck squamous cell carcinoma (HNSCC): a multi-institutional retrospective study.

Br J Radiol 2022 May 22;95(1133):20210033. Epub 2022 Feb 22.

Oncology-Radiotherapy Department, Henry-S.-Kaplan Cancer Center, CHRU de Tours, Tours, France.

Objectives: The aim of this retrospective study was to assess outcomes of SABR for metachronous isolated lung oligometastases from HNSCC.

Methods: For patients who developed isolated, 1 or 2 lungs lesions (<5cm) consistent with metastases from HNSCC, the indication of SABR was validated in a multidisciplinary tumor board. All patients were monitored by CT or PET CT after SABR (Stereotactic Ablative Body Radiation) for HNSCC. Read More

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CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer and by downregulating miR-514a-5p.

Bioengineered 2022 02;13(2):4372-4384

Department of General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, China.

Thyroid cancer (TC) often manifests in the form of a painless cervical mass or nodule and continues to increase in incidence. Currently, much less is known about its pathogenesis in TC cells. This study sought to figure out what role the circular RNA (circRNA) ZNF609/miR-514a-5p might play in TC development and metastasis. Read More

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February 2022

A case of cardiac metastases from head and neck cancer presenting as hyperdense armored heart.

Int Cancer Conf J 2022 Jan 9;11(1):23-26. Epub 2021 Sep 9.

Department of Head and Neck Surgery, Miyagi Cancer Center, 47-1 Nodayama, Medeshima-Shiode, Natori, Miyagi 981-1293 Japan.

Cardiac metastases from head and neck cancers are sometimes found at autopsy, but are rarely found before death; therefore, case reports are uncommon. In this report, we describe a case of cardiac metastasis from head and neck cancer. Although asymptomatic at the time of detection, positron emission tomography-computed tomography was effective in ascertaining the diagnosis. Read More

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January 2022

"MYH9 mutation and squamous cell cancer of the tongue in a young adult: a novel case report".

Diagn Pathol 2022 Feb 6;17(1):23. Epub 2022 Feb 6.

Department of Head and Neck Surgery, Wollongong Hospital, Wollongong, NSW, Australia.

Background: The incidence of tongue cancer in young adults is on the rise. This trend is more pronounced in females. Although the aetiology is still unclear, there is mounting evidence that genetic syndromes can play a key role in development of oral cancers in this patient group. Read More

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February 2022

Perfusion defects in non-enlarged metastatic lymph nodes using vessel wall magnetic resonance imaging: Detection performance and diagnostic value.

Clin Exp Metastasis 2022 06 4;39(3):421-431. Epub 2022 Feb 4.

Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi, 980-8575, Japan.

A perfusion defect (PD) in non-enlarged lymph nodes (LNs) of oral squamous cell carcinoma (OSCC) is the most reliable radiological criterion for the diagnosis of metastasis. However, conventional contrast-enhanced (CE) T1 weighted images using turbo spin echo (TSE) sequence is limited in detecting PD in non-enlarged LNs due to flow artifacts from cervical blood vessels. Vessel wall (VW) MR imaging with blood vessel flow suppression and high spatial resolution may provide new insights into the detection of PD. Read More

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NBTXR3, a first-in-class radioenhancer for pancreatic ductal adenocarcinoma: Report of first patient experience.

Clin Transl Radiat Oncol 2022 Mar 11;33:66-69. Epub 2022 Jan 11.

The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background And Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading causes of cancer-related deaths in the world. For patients with PDAC who are not eligible for surgery, radiation therapy improves local disease control, yet safely delivering therapeutic doses of radiation remains challenging due to off-target toxicities in surrounding normal tissues. NBTXR3, a novel radioenhancer composed of functionalized hafnium oxide crystalline nanoparticles, has recently shown clinical activity in soft tissue sarcoma, hepatocellular carcinoma, head and neck squamous cell carcinoma, and advanced solid malignancies with lung or liver metastases. Read More

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