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Auris Nasus Larynx 2019 Apr 3. Epub 2019 Apr 3.

Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Lymph node metastasis from signet ring cellcarcinoma (SRCC) primary unknown is extremely rare. We here report a case of primary-unknown SRCC that metastasized to the cervical lymph nodes, co-existing with mucoepidermoid carcinoma (MEC) of the parotid gland as a simultaneous double cancer. A 68-year-old female patient with right swollen cervical lymph nodes consulted our medical center. Read More

Oral Oncol 2019 Apr 16;91:7-12. Epub 2019 Feb 16.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. Electronic address:

Objectives: Epstein-Barr virus (EBV)-positive cervical lymph node (CLN) metastasis of unknown primary origin is classified as nasopharyngeal carcinoma (NPC) T0 by the American Joint Committee on Cancer staging manual (8th edition). We aimed to investigate the possible primary sites and patterns of EBV-positive CLN metastases and to provide implications for the management of NPC T0 classification.

Materials And Methods: We retrospectively reviewed 269 patients with newly diagnosed EBV-positive CLN metastatic disease who underwent EBV detection via EBV-encoded RNA in situ hybridization. Read More

Nuklearmedizin 2019 Mar 27;58(2):93-100. Epub 2019 Mar 27.

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden.

Aim: Retrospective evaluation of serial FDG-PET/CT scans in head and neck squamous cell cancer (HNSCC) patient's follow-up after primary radiochemotherapy (RCTx), to assess the diagnostic accuracy of an experienced observer vs. an objective classification compared to standard clinical follow-up examinations.

Methods: Sixty-nine patients with locally advanced HNSCC were included, who received curative RCTx. Read More

Acta Chir Belg 2019 Mar 25:1-7. Epub 2019 Mar 25.

d Department of Anatomopathology, Hotel-Dieu de France Hospital, Faculty of Medicine , Saint-Joseph University , Beirut , Lebanon.

Background: High-resolution sonography is becoming a method of choice for the detection and diagnosis of cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). The purpose of this study is to assess the diagnostic accuracy of neck ultrasound (US) in the detection of lymph node metastases from PTC.

Methods: Data for all patients with papillary thyroid cancers and preoperative neck US were reviewed retrospectively. Read More

Surgery 2019 Mar 12. Epub 2019 Mar 12.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Lymph node metastases from papillary thyroid cancer is believed to disseminate sequentially, first to the central neck and later to the lateral neck. Skip metastases of papillary thyroid cancer, however, are defined as lateral lymph node metastasis without central lymph node metastasis. The aim of this study was to investigate the risk factors for skip metastases and lateral lymph node metastasis of papillary thyroid cancer. Read More

AJR Am J Roentgenol 2019 Mar 12:1-8. Epub 2019 Mar 12.

1 Department of Radiology, University of Minnesota Medical Center, Fairview, 420 Delaware St SE, B-226 Mayo Memorial Bldg, MMC 292, Minneapolis, MN 55455.

Objective: The aim of this study is to assess the utility of pretreatment whole-body F-FDG PET/CT in screening for distant metastasis (DM) and regional lymphatic metastasis (LM).

Materials And Methods: Eighty-nine consecutive patients with untreated sinonasal malignant lesions (32 women and 57 men; mean age, 62 years) underwent whole-body FDG PET/CT between January 2009 and August 2017. A retrospective analysis was performed to determine the presence of DM and LM. Read More

Auris Nasus Larynx 2019 Mar 8. Epub 2019 Mar 8.

Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: The purpose of this study was to evaluate the usefulness of ultrasound (US) volume measurement of the cervical lymph nodes for diagnosing nodal metastasis in patients with head and neck cancer using a node-by-node comparison.

Methods: Thirty-four consecutive patients with head and neck cancer from one tertiary university hospital were prospectively enrolled from 2012 to 2017. Patients with histologically proven squamous cell primary tumors in the head and neck region scheduled to undergo a therapeutic neck dissection were eligible. Read More

Am J Case Rep 2019 Mar 11;20:318-322. Epub 2019 Mar 11.

Osteopathic Medical Student, University of Pikeville-Kentucky College of Osteopathic Medicine, Pikeville, KY, USA.

BACKGROUND Sarcomas account for less than 1% of all cancers. Undifferentiated Pleomorphic Sarcoma, formerly called Malignant Fibrous Histiocytoma, is a rare subtype identified by a lack specific immunohistochemical markers for a specific lineage of differentiation. These soft tissue tumors are aggressive and rapidly enlarge. Read More

Head Neck 2019 Mar 4. Epub 2019 Mar 4.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC-Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC).

Methods: In 149 FNA samples of 114 patients, SCC-Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection.

Results: SCC-Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0. Read More

Semin Radiat Oncol 2019 04;29(2):93-101

Wright Center of Innovation in Biomedical Imaging, Division of Imaging Science, Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

The purpose of this article is to present the recent imaging advancements enabled by digital photon counting positron emission tomography detector technology and discuss its potential applications in the clinical management of head and neck cancer (HNC) and nodal metastases. F-fluorodeoxyglucose positron-emission tomography is a clinically useful biomarker for the detection, targeted biopsy, treatment planning, and therapeutic response assessment of HNC. This article highlights the current state of F-fluorodeoxyglucose positron-emission tomography imaging in HNC management as well as the emerging capabilities of the recently introduced digital photon counting positron emission tomography/computed tomography platform for more effective molecular and functional HNC imaging. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):23-27

Department of Head and Neck Surgery, Beijing Cancer Hosptial, Beijing Institute for Cancer Research, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing 100142, China.

To investigate the diagnostic performance of fine-needle aspiration (FNA) cytology for the detection of lateral lymph node metastases in patients with papillary thyroid carcinoma (PTC). A total of 109 lateral lymph nodes with suspicious metastases from 85 patients were retrospectively subjected to FNAC, fine-needle aspiration thyroglobulin measurement (FNATg), and FNATg/SerumTg measurement. Lymph node pathological results after surgery were taken as the gold standard. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Feb;48(2):127-131

Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China.

To observe the clinicopathologic features of oropharyngeal squamous cell carcinoma associated with human papilloma virus (OPSCC-HPV) and discuss the role and value of different in situ hybridization (ISH) detection methods for HPV in pathologic diagnosis. Fifteen cases of OPSCC-HPV were collected from Department of Pathology, Beijing Tongren Hospital, Capital Medical University from January 2016 to August 2018. These cases were diagnosed in accordance with the WHO classification of head and neck tumors. Read More

Acta Otolaryngol 2019 Jan 24;139(1):94-99. Epub 2019 Jan 24.

a Department of Otolaryngology, and Head & Neck Surgery , Kanazawa University , Kanazawa , Japan.

Background: In sentinel lymph node (SLN) biopsy for head and neck cancers, the radioisotope method has been the gold standard. However, this method has several problems, such as unavoidable radiation exposure and requirements of expensive equipment.

Aims/objectives: To overcome these problems, we evaluated the contrast-enhanced ultrasonography (CEUS)-guided SLN-detection method, and predicted the SLN metastatic status using novel ultrasound technology, superb microvascular imaging (SMI). Read More

Oncol Lett 2019 Feb 14;17(2):2457-2464. Epub 2018 Dec 14.

Department of Radiation Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210000, P.R. China.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer. Early detection and management of HNSCC may prevent progression of the disease. Long non-coding RNAs (lncRNAs) may serve as prognostic biomarkers for various cancer types. Read More

Rev Esp Med Nucl Imagen Mol 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, University Hospital 12 de Octubre, Madrid, España.

Purpose: The aim is to investigate the use of F-FDG (fluorine-18 fluorodeoxyglucose) PET/CT in head and neck cancer (HNC) staging and its effect on the therapeutic strategy and radiotherapy (RT) planning.

Methods And Materials: One hundred patients with HNC were included. Primary tumor sites: 18% oral cavity, 20% oropharynx, 12% hypopharynx, 11% nasopharynx, 37% larynx, 2% paranasal sinuses. Read More

Oral Oncol 2019 Jan 30;88:145-152. Epub 2018 Nov 30.

Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. Read More

Oral Oncol 2019 Jan 23;88:109-114. Epub 2018 Nov 23.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Objectives: Current guidelines recommend chest computed tomography (CT) with locoregional CT/magnetic resonance imaging for patients with head and neck squamous cell carcinoma (HNSCC), and F-fluorodeoxyglucose (FDG) positron-emission tomography (PET)/CT is suggested for stage III-IV patients. However, whole body screening with F-FDG PET/CT may provide better detection of distant metastases and synchronous cancer than conventional imaging. We evaluated the utility of F-FDG PET/CT in detecting distant metastasis and synchronous cancer. Read More

Head Neck 2019 Apr 21;41(4):1112-1121. Epub 2018 Dec 21.

Humanitas Clinical and Research Center, Rozzano (MI).

Background: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.

Methods: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy. Read More

Eur J Cancer 2019 Jan 12;107:86-92. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Odense University Hospital, Denmark.

Objective: The objective is to investigate the topographical distribution of sentinel nodes (SNs) and lymph node metastases in T1-2cN0 oral squamous cell carcinomas (OSCCs).

Methods: The study entailed a prospective enrolment of 220 patients with clinical T1-2N0 OSCCs who underwent preoperative lymphoscintigraphy (LSG) followed by gamma probe-guided sentinel lymph node biopsy (SLNB). Patients with positive SNs were treated with completion neck dissection. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1480-1482

Department of Head and Neck Surgery,Jiangxi Provincal Cancer Hospital.

To investigate the feasibiity of detecting lymph node metastasis in differentiated thyroid cancer patients by thyroglobin（Tg）measurement in fine-needle aspiration washout fluid. Forty-seven differentiated thyroid cancer patients with cervical lymph node metastasis were included in this study. Fine-needle aspirations were performed on lymph nodes which were surgically resected for measurement of Tg in washout fluid. Read More

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

EJNMMI Res 2018 Dec 3;8(1):104. Epub 2018 Dec 3.

INSERM 1086 ANTICIPE, Normandie University, Caen, France.

Background: FDG PET/CT is crucial before neck surgery for nodal recurrence localization in iodine-refractory differentiated or poorly differentiated thyroid cancer (DTC/PDTC). A dedicated head-and-neck (HN) acquisition performed with a thin matrix and point-spread-function (PSF) modelling in addition to the whole-body PET study has been shown to improve the detection of small cancer deposits. Different protocols have been reported with various acquisition times of HN PET/CT. Read More

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

Facial Plast Surg Clin North Am 2019 Feb;27(1):119-129

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, Houston, TX 77030-4009, USA. Electronic address:

Sentinel lymph node biopsy uses the concept of selective lymphatic drainage and the lymphatic microvasculature to identify first-echelon nodes draining a given malignancy. Although initially considered difficult and unreliable in the head and neck, experience with the technique has improved and evolved significantly over the last 3 decades. It is now recognized to be accurate and reliable for regional nodal staging and detection of occult nodal metastasis in the head and neck. Read More

Indian J Nucl Med 2018 Oct-Dec;33(4):326-330

Department of Head and Neck Surgical Oncology, HCG Cancer Centre, Ahmedabad, Gujarat, India.

Metastasis to the thyroid gland is rare; furthermore, intrathyroid metastasis from head and neck squamous cell carcinoma (SCC) is very unusual, with only nine previously documented cases four from intrathyroid metastasis from nasopharyngeal carcinoma, two from oral cavity, one each from oropharynx, larynx, and parotid. The reported case series are unique in nature and illustrates the role of fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) and ultrasound-guided biopsy in diagnosing clinically occult isolated intrathyroidal metastasis, which helps in the best management for an isolated intrathyroid metastases. This study details the cases of three patients who were diagnosed with intrathyroidal metastasis from SCC of the tongue by PET-CT, followed by USG-guided biopsy, who were treated with either surgery and or chemotherapy. Read More

Clin Nucl Med 2019 Jan;44(1):11-20

Division of Endocrine Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.

Purpose: The aim of this study was to determine clinical outcomes in patients with differentiated thyroid cancer after surgery and activity-adjusted I therapy informed by diagnostic I scans with SPECT/CT (Dx scan).

Methods: Single-institution retrospective cohort study analysis of clinical outcomes after 1 to 5 years (mean, 39.6 ± 23. Read More

Eur J Radiol 2018 Oct 11;107:20-25. Epub 2018 Aug 11.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.

Background And Purpose: Head and neck squamous cell carcinoma (HNSCC) may present with cervical metastases without an apparent primary tumor. Detecting the primary tumor results in more targeted treatment. Acquisition of DWI is improving with less artifacts and image distortion. Read More

Medicine (Baltimore) 2018 Oct;97(40):e12578

Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing.

This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. Read More

PLoS One 2018 20;13(9):e0204249. Epub 2018 Sep 20.

Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Oral cavity squamous cell carcinoma (OCC) and oropharyngeal squamous cell carcinoma (OPC) are among the most common cancers worldwide and are associated with high mortality and morbidity. The purpose of this study is to identify potential biomarkers to distinguish OCC/OPC from normal controls and to distinguish OCC patients with and without nodal metastasis. We tested saliva samples from 101 OCC, 58 OPC, and 35 normal controls using four analytical platforms (NMR, targeted aqueous by LC-MS/MS, global aqueous and global lipidomics by LC-Q-TOF). Read More

Int J Nanomedicine 2018 31;13:4977-4986. Epub 2018 Aug 31.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China,

Background: Tumor stages detection and histologic grades classification are essential for the diagnosis and prognosis of oral squamous cell carcinoma (OSCC). In this research, we apply surface-enhanced Raman spectroscopy (SERS) of blood serum to detect the tumor stages and histologic classification of OSCC.

Methods: According to TNM classification and World Health Organization histologic grading system, the blood serum samples were collected from a total of 135 OSCC patients in the different tumor stages and histologic grades. Read More

Cell Physiol Biochem 2018 11;49(4):1364-1379. Epub 2018 Sep 11.

Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China.

Background/aims: Sinonasal mucosal melanoma (SMM) is a rare but extremely aggressive disease. Interestingly, however, as lethal as SMM, a few patients could survive for over 5 years without metastasis. However, biomarkers for metastatic SMM are lacking. Read More

Laryngoscope 2018 11 8;128(11):2573-2575. Epub 2018 Sep 8.

Department of Facial Plastic and Reconstructive Surgery , Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, U.S.A.

Objectives/hypothesis: With positron emission tomography/computed tomography (PET/CT) now commonplace as a diagnostic tool, new questions have arisen regarding the utility and cost-effectiveness of panendoscopy. In this retrospective review of a large cohort of head and neck squamous cell carcinoma of unknown primary (HNSCC-UP), we describe the enduring utility of panendoscopy in the detection of the primary site of mucosal disease even when PET/CT is negative.

Study Design: Retrospective cohort study. Read More

Clin Nucl Med 2018 Nov;43(11):e402-e403

From the Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia.

We present a case of a tongue squamous cell carcinoma (SCC) metastasizing to distal skeletal muscle detected on FDG PET/CT imaging. A 48-year-old man with locally recurrent tongue SCC underwent a restaging FDG PET/CT to investigate neck and unilateral leg pain. The PET scan showed large, intensely FDG-avid lesions in the right scalene and left hamstring muscles, which were biopsy proven as metastatic SCC. Read More

J Vet Med Sci 2018 Nov 30;80(10):1544-1548. Epub 2018 Aug 30.

Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Research Organization, 4 Hitsujigaoka, Toyohira, Sapporo, Hokkaido 062-0045, Japan.

An 8-month-old male Japanese Black calf was referred for the evaluation of a slow-growing conjunctival mass in the right eye. A superficial keratectomy was performed followed by recurrence on two occasions. No metastases were found in surrounding tissues. Read More

J Craniomaxillofac Surg 2018 Oct 3;46(10):1748-1752. Epub 2018 Aug 3.

Department of Oral, Maxillary and Plastic Facial Surgery, German Armed Forces Hospital, Ulm, Germany; Department of Oral and Maxillofacial Surgery, University Hospital, Ulm, Germany. Electronic address:

Purpose: This study investigates the possibility and sensibility of using sentinel node biopsy (SNB) during surgery for oropharyngeal carcinomas with clinically and radiographically unremarkable cervical lymph nodes.

Materials And Methods: A total of 36 patients who were treated for early oral and oropharyngeal carcinoma and unremarkable cervical lymph nodes were included in this study. After lymphoscintigraphy for detecting sentinel lymph nodes (SLN), the SLN were excised first. Read More

Biomed Pharmacother 2018 Oct 14;106:983-990. Epub 2018 Jul 14.

Department of Endocrinology, Institute of Endocrinology and Metabolism, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:

miRNAs is a kind of noncoding small RNAs with negative regulation function. Some miRNAs play a crucial role in the growth of tumor cells. In this study, we analyzed the role of miR-335-5p and its target gene intercellular adhesion molecule 1 (ICAM-1) in thyroid cancer. Read More

Int J Mol Sci 2018 Aug 16;19(8). Epub 2018 Aug 16.

Department of Oral and Maxillofacial Surgery, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.

Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little improvement in the last three decades. Comprehensive elucidation of OSCC's molecular mechanism is imperative for early detection and treatment, improving patient survival. Read More

Respiration 2018 4;96(2):138-143. Epub 2018 Jul 4.

Interventional Respiratory Unit, Galway University Hospital, Galway, Ireland.

Background: Cervical lymph nodes are frequently involved in patients with lung cancer and indicate inoperability. Some guidelines recommend neck ultrasound (NUS) in patients with bulky mediastinal lymphadenopathy. Positron emission tomography (PET) is indicated for patients with potentially curable disease. Read More

Endocrine 2018 11 2;62(2):340-350. Epub 2018 Jul 2.

Regional Center of Nuclear Medicine, Hospital University of Pisa, Pisa, Italy.

Purpose: Sentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma (PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged as a promising minimally invasive procedure to detect metastatic nodes.

Methods: The MEDLINE database was searched via the PubMed interface on 10 January 2018 for the MeSH headings "sentinel lymph node biopsy" and "thyroid carcinoma".

Results: Vital blue dye, radioisotope, and the combination of both techniques are used in PTC patients. Read More

J Pediatr Endocrinol Metab 2018 Jul;31(7):751-756

Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.

Background The present study was designed to determine the value of pre-ablation stimulated thyroglobulin (s-Tg) in predicting distant metastasis (DM) at the time of ablation in children with differentiated thyroid cancer. Methods From August 2009 to December 2016, consecutive children with differentiated thyroid cancer undergoing remnant ablation were retrospectively analyzed. Serum s-Tg was measured with the high-sensitive electrochemiluminescence immunoassay during hypothyroidism at ablation just before the ablative radioactive iodine (131I) administration. Read More

Case Rep Oncol 2018 May-Aug;11(2):289-297. Epub 2018 May 17.

Department of Oncology - ESMO European Society for Medical Oncology - Designated Centre of Integrated Oncology and Palliative Care, Poliambulanza Foundation Hospital, Brescia, Italy.

Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Read More

BMC Cancer 2018 Jun 20;18(1):672. Epub 2018 Jun 20.

Department of Otorhinolaryngology - Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity of the disease, the clinical outcomes, prognostic factors and clinical decision on the optimal treatments have not been fully understood.

Methods: In this study, we retrospectively analyzed the clinical data of 124 patients with high-grade salivary gland cancers and performed multivariate survival analyses to evaluate the clinico-pathological factors affecting the treatment outcomes. Read More

Neurosurg Focus 2018 Jun;44(6):E11

Departments of1Neurosurgery.

Squamous cell carcinoma of the head and neck (HNSCC) affects nearly 500,000 individuals globally each year. With the rise of human papillomavirus (HPV) in the general population, clinicians are seeing a concomitant rise in HPV-related HNSCC. Notably, a hallmark of HPV-related HNSCC is a predilection for unique biological and clinical features, which portend a tendency for hematogenous metastasis to distant locations, such as the brain. Read More

Horm Res Paediatr 2018 25;90(1):66-72. Epub 2018 May 25.

Division of Pediatric Endocrinology and Diabetes, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Papillary thyroid cancer (PTC) is an uncommon pediatric disease with an excellent prognosis. In follow-up surveillance, neck ultrasound (US), basal and thyroid-stimulating hormone-stimulated serum thyroglobulin (Tg) levels, and diagnostic whole-body radioactive iodine scans (DxWBS) have been traditionally used in both adults and children for the detection of recurrence or metastases of PTC.

Methods: Two pediatric patients with metastatic PTC were followed after standard ablative treatment with routine neck US and serum Tg levels, as well as periodic DxWBS. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 May;32(9):687-692

Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

To investigate the expression of C-fos in patients with nasopharyngeal carcinoma(NPC), and analyze the relationship between the expression of C-fos and the clinical characteristics, chemosensitivity and prognosis. Clinical and follow-up data of 75 NPC patients was analyzed retrospectively. The expression of C-fos was detected by immunohistochemical assay, and chemosensitivity was detected by ATP bioluminescent anticancer drug sensitivity detection technology. Read More

Eur J Nucl Med Mol Imaging 2018 Nov 15;45(12):2159-2169. Epub 2018 May 15.

Department of Biomedical Imaging and Image-Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Waehringer-Guertel 18-20, A-1090, Vienna, Austria.

Purpose: Medullary thyroid carcinoma (MTC) is characterized by a high rate of metastasis. In this study we evaluated the ability of [F]DOPA PET/ceCT to stage MTC in patients with suspicious thyroid nodules and pathologically elevated serum calcitonin (Ctn) levels prior to total thyroidectomy and lymph node (LN) dissection.

Methods: A group of 32 patients with sonographically suspicious thyroid nodules and pathologically elevated basal Ctn (bCtn) and stimulated Ctn (sCtn) levels underwent DOPA PET/ceCT prior to surgery. Read More

Acta Radiol 2019 Feb 12;60(2):186-195. Epub 2018 May 12.

2 Department of Radiology, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.

Background: The early and accurate detection of local or regional recurrence of head and neck tumor is critically important.

Purpose: To compare the diagnostic accuracy of contrast-enhanced computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI), and fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT, alone and in combination, in detecting the locoregional recurrence of malignant head and neck tumor.

Material And Methods: A total of 93 patients with loco-regional recurrence of malignant head and neck tumors underwent CT, MRI, and PET-CT within 30 days before surgery. Read More

Int J Surg 2018 Aug 16;56:49-56. Epub 2018 May 16.

Department of Thyroid and Breast Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China. Electronic address:

Background: The aim of this study was clarify the diagnostic accuracy of one step nucleic acid amplification (OSNA) for differentiating metastatic lymph nodes from non-metastatic ones in patients with tumors (not including breast cancer).

Methods: A systematic literature search for original diagnostic studies was performed in PubMed. Findings were pooled by using combined effect models and hierarchic summary receiver operating characteristic curve models. Read More

World J Nucl Med 2018 Apr-Jun;17(2):123-125

Department of Nuclear Medicine, Royal Liverpool University Hospital, Liverpool, Merseyside, UK.

Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genetic disorder characterized by small papular skin lesions (fibrofolliculomas) causing susceptibility to kidney cancer, renal and pulmonary cysts, spontaneous pneumothoraces, and several noncutaneous tumors. We report a case of a 67-year-old woman, with a previous history of right hemithyroidectomy for adenomatous lesion. She presented with a swelling in the right thyroid bed that on subsequent biopsy revealed features of metastatic carcinoma. Read More

J Craniomaxillofac Surg 2018 Jun 5;46(6):1001-1006. Epub 2018 Apr 5.

Department of Pathology University Medical Center Utrecht, Heidelberglaan 100, H4.4129, PO Box 85500, NL 3508 GA, Utrecht, The Netherlands.

Introduction: In oral squamous cell carcinoma (OSCC) the differentiation grade of the tumor is determined on the biopsy and the resection specimen. The relation between tumor grade, nodal metastasis and survival is debatable. The aims of this study were to determine the correlation between differentiation grade of the biopsy and the resection specimen. Read More