314,482 results match your criteria Neck Cervical Metastases Detection


Measurements of Trunk Sway for Stance and Gait Tasks 2 Years after Vestibular Neurectomy.

Audiol Neurootol 2018 Dec 12;23(5):298-308. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

The aim of this study was to investigate changes in balance control for stance and gait tasks in patients 2 years before and after vestibular neurectomy (VN) performed to alleviate intractable Meniere's disease. Amplitudes of trunk sway in roll and pitch directions were measured for stance and gait tasks in 19 patients using gyroscopes mounted at the lower-back. Measurements before VN and 2 years later were compared to those of healthy age-matched controls (HC). Read More

View Article
December 2018

Aggressive fibromatosis of the parotid gland.

Ear Nose Throat J 2018 Dec;97(12):E28-E30

Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Extra-abdominal fibromatosis (EAF) is a rare, locally aggressive tumor that originates in fascial structures. It accounts for less than 0.3% of all tumors diagnosed. Read More

View Article
December 2018

Destructive lesion of the temporomandibular joint: A case of tophaceous pseudogout.

Ear Nose Throat J 2018 Dec;97(12):E18-E20

Department of Otolaryngology-Head and Neck Surgery, Virginia Commonwealth University, West Hospital, 1200 East Broad St., 12th Floor, South Wing, Suite 313, Box 980146, Richmond, VA 23298-0146, USA.

Tophaceous pseudogout of the temporomandibular joint is a rare entity that clinically and radiographically mimics neoplastic or infectious conditions. Diagnosis requires histopathologic examination. Given the rarity of this condition, there is a paucity of information pertaining to the surgical approach, reconstructive options, and postoperative outcomes. Read More

View Article
December 2018

A fistulating oropharyngeal lesion.

Ear Nose Throat J 2018 Dec;97(12):E15-E17

Department of Otorhinolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85084, USA.

Post-transplant lymphoproliferative disorder (PTLD) is a unifying term for a spectrum of lymphoid expansion entities brought about by immunosuppression. It can present throughout the head and neck, and tonsillar involvement is not limited to children. We report the case of a 67-year-old woman who developed odynophagia associated with putrid halitosis 4 months after she had undergone renal transplantation. Read More

View Article
December 2018

An unusual presentation of papillary thyroid carcinoma in a pediatric patient: A case report.

Ear Nose Throat J 2018 Dec;97(12):E7-E10

University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.

Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More

View Article
December 2018
2 Reads

Endoscopic medialization middle turbinoplasty in endoscopic sinus surgery.

Ear Nose Throat J 2018 Dec;97(12):404-410

Department of Otolaryngology-Head and Neck Surgery, Tufts University School of Medicine, Tufts Medical Center, 800 Washington St., Box 850, Boston, MA 02111, USA. Email:

Recurrence of sinonasal disease can be caused by many factors, including lateralization of the middle turbinate as a complication of endoscopic sinus surgery (ESS). Different ESS procedures have been tried to prevent this complication. We conducted a prospective study to determine if medialization is an effective means of lateralizing the middle turbinate. Read More

View Article
December 2018

KTP-laser-assisted endoscopic management of glomus tympanicum tumors: A case series.

Ear Nose Throat J 2018 Dec;97(12):399-402

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, 801 Welch Rd., Stanford, CA 94035, USA.

Endoscopic technology is widely used in rhinology and anterior skull base surgery, but it has been less quickly incorporated into otologic practice. The design of the instrumentation forces surgeons to work one-handed and limits depth perception. Nevertheless, endoscopy also offers wide fields of view and access to spaces that are typically difficult to visualize. Read More

View Article
December 2018
1 Read

Association of Ménière disease with human leukocyte antigen in Taiwanese population.

Ear Nose Throat J 2018 Dec;97(12):396-402

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

The etiology of Ménière disease (MD) is multifactorial; genetic factors seem to play an important role. The associations between MD and human leukocyte antigen (HLA) status have been studied previously in several populations and have shown that the HLA alleles imparting susceptibility varied. In the present study, we explored HLA status in Taiwanese patients with definitive MD. Read More

View Article
December 2018
1 Read

Unforeseen consequence of alkaline water therapy for laryngopharyngeal reflux.

Ear Nose Throat J 2018 Dec;97(12):394-395

Department of Otolaryngology-Head and Neck Surgery, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.

View Article
December 2018

In-office sinonasal procedures in the elderly.

Ear Nose Throat J 2018 Dec;97(12):392-393

Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Canada.

View Article
December 2018

An unusual case of persistent dysphagia.

Ear Nose Throat J 2018 Dec;97(12):391

Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USA.

View Article
December 2018

Huge neck lymphangioma removed in toto with minimal access.

Ear Nose Throat J 2018 Dec;97(12):389-390

Department of ENT and Head and Neck Surgery, Maulana Azad Medical College, New Delhi, India.

View Article
December 2018

Decomposing the subclonal structure of tumors with two-way mixture models on copy number aberrations.

PLoS One 2018 12;13(12):e0206579. Epub 2018 Dec 12.

Institute of Statistics, National Tsing Hua University, Hsinchu, Taiwan, R.O.C.

Multistage tumorigenesis is a dynamic process characterized by the accumulation of mutations. Thus, a tumor mass is composed of genetically divergent cell subclones. With the advancement of next-generation sequencing (NGS), mathematical models have been recently developed to decompose tumor subclonal architecture from a collective genome sequencing data. Read More

View Article
December 2018

Predictive Value of Head-Neck CTA Combined with ABCD2 Scale Score for Patients with Cerebral Infarction of Vertebrobasilar Transient Ischemic Attack (TIA).

Med Sci Monit 2018 Dec 12;24:9001-9006. Epub 2018 Dec 12.

Department of Radiology, Baoding First Central Hospital, Beijing, China (mainland).

BACKGROUND The present study was designed to evaluate the predictive value of head-neck computed tomography angiography (CTA) combined with ABCD2 score scale for patients with cerebral infarction of vertebrobasilar transient ischemic attack (TIA). MATERIAL AND METHODS A total of 92 patients with TIA who were admitted to our hospital from January 2014 to June 2015 were enrolled in this study. ABCD2 score and CTA combined with ABCD2 score were assessed. Read More

View Article
December 2018

Poor Baseline Mental Health Does Not Influence Improvement in Patient-Reported Outcomes, Satisfaction and Return To Work Two Years After Single-Level Anterior Cervical Discectomy and Fusion.

Spine (Phila Pa 1976) 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Singapore General Hospital, Singapore.

Study Design: Retrospective study using prospectively collected registry data.

Objectives: The authors examine the influence of preoperative mental health on outcomes after anterior cervical discectomy and fusion (ACDF) and determine the impact of ACDF on postoperative mental health.

Summary Of Background Data: While studies have reported a negative correlation between preoperative mental health and outcomes following lumbar spine surgery, the influence on outcomes following cervical spine surgery remains relatively understudied. Read More

View Article
December 2018

Long-term Outcomes of Ossiculoplasty With and Without an Intact Malleus.

Otol Neurotol 2019 Jan;40(1):73-78

Division of Otology and Neurotology, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Objective: To compare long-term hearing outcomes following ossiculoplasty with cartilage tympanoplasty with (M) and without (M) the malleus present.

Study Design: Retrospective chart review.

Setting: Tertiary referral center. Read More

View Article
January 2019

Novel Treatment Options for the Surgical Management of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S33-S37

Orthopaedic Trauma Service, Hospital for Special Surgery, New York, NY.

In physiologically young patients with displaced femoral neck fractures, surgical treatment is aimed at achieving fracture union while preserving native hip anatomy and biomechanics. The intracapsular environment, tenuous vascular supply, and unfavorable hip biomechanics contribute to the high complication rates seen after osteosynthesis of these fractures. Conventional fixation methods for osteosynthesis of femoral neck fractures include multiple cancellous screws, fixed-angle dynamic implants, and fixed-angle length-stable constructs. Read More

View Article
January 2019

Biomechanics of Femoral Neck Fractures and Implications for Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S27-S32

*Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; and †Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria.

Fractures of the femoral neck can occur in young healthy individuals due to high loads occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts occur sideways onto the greater trochanter as compared with vertical loading of the hip. Bone density, bone geometry, and thickness of cortical bone at the femoral neck contribute to its mechanical strength. Read More

View Article
January 2019

Technologies for Young Femoral Neck Fracture Fixation.

J Orthop Trauma 2019 Jan;33 Suppl 1:S20-S26

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Fixation of young femoral neck fractures represents a challenge in the field of orthopaedic trauma surgery. Conventional methods, including cannulated screw and sliding hip screw constructs, have been studied and found to have similar results with regards to patient outcomes, which has made choosing an optimum fixation strategy difficult. In all of these cases, quality of reduction has been shown to be the most important factor when it comes to creating a favorable environment for fracture healing. Read More

View Article
January 2019

Reduction Techniques for Young Femoral Neck Fractures.

Authors:
Jason Halvorson

J Orthop Trauma 2019 Jan;33 Suppl 1:S12-S19

Department of Orthopedic Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC.

Young femoral neck fractures remain challenging fractures to treat. Reduction has repeatedly been shown to be the single most important determinant of patient outcome, and treating surgeons should do all they can to achieve anatomic reduction because this is an outcome variable within the surgeon's control. Whether an open or closed reduction is performed, we hope to provide the reader with reduction strategies when faced with this difficult fracture pattern. Read More

View Article
January 2019

Femoral Neck Fractures in Young Patients: State of the Art.

Authors:
Daniel S Chan

J Orthop Trauma 2019 Jan;33 Suppl 1:S7-S11

Orthopaedic Trauma Institute, NavicentHealth, Macon, GA.

Femoral neck fractures in young patients are uncommon but are often associated with surgical challenges and complications. The quality of reduction, more than time to surgery, has the most impact on optimizing outcomes and function. There is no consensus in the best fixation construct for these fractures. Read More

View Article
January 2019
1 Read

Treatment of Young Femoral Neck Fractures.

J Orthop Trauma 2019 Jan;33 Suppl 1:S1-S6

Department Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Femoral neck fractures in the physiologically young patient are challenging injuries to manage. A tenuous blood supply and the intrasynovial nature of the fracture create a challenging biological environment. To make matters worse, the biomechanics are equally problematic. Read More

View Article
January 2019

Femoral Neck Fractures in the Physiologically Young Patient.

Authors:
Eben A Carroll

J Orthop Trauma 2019 Jan;33 Suppl 1:S1

Department of Orthopaedic Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

View Article
January 2019

Surgical Algorithmic Approach to Facilitate Primary Closure of the Anterolateral Thigh Flap Donor Site in Head and Neck Reconstruction.

Ann Plast Surg 2018 Dec 6. Epub 2018 Dec 6.

Department of Plastic and Reconstructive Surgery, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City, Taiwan.

Background: Use of the anterolateral thigh (ALT) flap has gained popularity in head and neck reconstruction. However, donor sites that cannot achieve primary closure are reported to have poorer functional and aesthetic outcomes. Therefore, we propose an algorithm to facilitate primary closure of the donor site. Read More

View Article
December 2018
1 Read

mTOR, glycotoxins and the parallel universe.

Authors:
Alan S Green

Aging (Albany NY) 2018 Dec 12. Epub 2018 Dec 12.

The Medical Practice of Dr. Alan S. Green, Little Neck, NY 11363, USA.

View Article
December 2018
1 Read

Effect of fluoride application during radiotherapy on enamel demineralization.

J Appl Oral Sci 2018 Dec 10;27:e20180044. Epub 2018 Dec 10.

Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Dentística e Materiais Odontológicos, Uberlândia, Minas Gerais, Brasil.

Objective: Radiation-related caries are one the most undesired reactions manifested during or after head and neck radiotherapy. Fluoride application is an important strategy to reduce demineralization and enhance remineralizaton. To evaluate the effect of the topical application of fluoride during irradiation on dental enamel demineralization. Read More

View Article
December 2018

Oral health-related quality of life among male subjects with oral submucous fibrosis in a tertiary care hospital.

Indian J Public Health 2018 Oct-Dec;62(4):271-276

Senior Resident, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, Union Territory, India.

Background: Oral submucous fibrosis is very common in Asia. It has many deleterious effects on individual's oral functions. Thus, there is a need to assess the effect of oral submucous fibrosis on quality of life. Read More

View Article
December 2018

Multiple intercostal neurilemmomas in a Chinese woman.

J Cancer Res Ther 2018 Dec;14(Supplement):S1220-S1222

Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.

Neurilemmomas are rare tumors of neural crest cell origin that occur most commonly in the head and neck region. Intercostal neurilemmomas are extremely rare and are mostly seen as solitary tumors in the posterior mediastinum. Only one case report of multiple intercostal neurilemmomas has been documented previously. Read More

View Article
December 2018
1 Read

Meta-analysis of the relationship between excision repair cross-complementing Group 5 rs17655 gene polymorphism and head and neck cancer susceptibility.

J Cancer Res Ther 2018 Dec;14(Supplement):S1041-S1047

Department of Traditional Chinese Medicine, Scientific Research Platform, The Second Clinical Medical College, Guangdong Medical University; Department of Dongguan Scientific Research Center, Sino-American Cancer Research Institute, Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan, Guangdong, China.

Background: Published studies have evaluated the association between excision repair cross-complementing Group 5 (ERCC5) rs17655 polymorphism and head and neck cancer (HNC) susceptibility. However, these studies showed inconsistent results.

Aims: The aim of this study was to get a more comprehensive estimation of this association. Read More

View Article
December 2018

First recognized n-butanol concentration may be simple and useful index for assessing olfactory dysfunction in geriatric patients.

Aging Clin Exp Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Chung-Ang University College of Medicine, 102, Heukseok-ro, Dongjak-gu, Seoul, 156-755, Republic of Korea.

The KVSSII is widely used to evaluate olfactory function in the Korean population. We evaluated the usefulness of the first recognized n-butanol concentration, which is obtained at the beginning part of KVSS II, in predicting olfactory dysfunction. Three hundred seventy two subjects were enrolled in our study. Read More

View Article
December 2018

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Cell Oncol (Dordr) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Room 2029C, Ann Arbor, MI, 48109-1078, USA.

Purpose: Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be involved in the control over oncogenes, including c-MYC, and in the maintenance of downstream inflammatory processes. Read More

View Article
December 2018
1 Read

Oncocytic Sialolipoma of Parotid Gland: Case Report and Literature Review.

Head Neck Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ear, Nose and Throat, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.

Oncocytic sialolipoma is a very rare tumor of which only three cases have been reported. This entity is considered to be a variant of sialolipoma which harbours oncocytic nodules within a well-circumscribed lipomatous mass. We report a parotid mass in 73-year-old female that was difficult to diagnose in imaging and on biopsy. Read More

View Article
December 2018

Evaluation of the adherence of distress screening with the distress thermometer in cancer patients 4 years after implementation.

Support Care Cancer 2018 Dec 11. Epub 2018 Dec 11.

PhD Program, Department of Nursing Science, University Witten/Herdecke, Witten, Germany.

Purpose: Identifying and assessing psychosocial distress with an appropriate screening instrument is essential when caring for cancer patients. Since 2012, the distress thermometer (DT) has been used by nurses for all cancer inpatients at the Comprehensive Cancer Center Zurich. We wanted to identify nurses' adherence to the screening protocol, differences between screened and not screened patients and the relationship between screening rate and productivity. Read More

View Article
December 2018

Evaluation of retinal vasculature before and after treatment of children with obstructive sleep apnea-hypopnea syndrome by optical coherence tomography angiography.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Purpose: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA).

Methods: Sixty-two children with OSAS (124 eyes; 5.94 ± 1. Read More

View Article
December 2018

Transoral Robotic Thyroidectomy for Papillary Thyroid Carcinoma: Perioperative Outcomes of 100 Consecutive Patients.

World J Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Background: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). Read More

View Article
December 2018
2 Reads

Predictive factors for complications associated with penetrated fish bones outside the upper gastrointestinal tract.

Eur Arch Otorhinolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, 430030, China.

Purpose: To investigate predictive risk factors for complications associated with migrating fish bones in the surrounding tissue of upper gastrointestinal tract.

Methods: A retrospective analysis over 12 years was conducted of 45 cases of buried fish bones in the surrounding tissue of upper gastrointestinal tract with complications. Meanwhile, a control group, including 39 cases of prolonged buried fish bones in the surrounding tissue of upper gastrointestinal tract without complications, was set. Read More

View Article
December 2018
1 Read

Inversion of the acetabular labrum causes increased localized contact pressure on the femoral head: a biomechanical study.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan.

Purpose: Although studies suggest that subchondral insufficiency fracture of the femoral head may cause rapidly progressive osteoarthritis of the hip, the mechanism of that relationship remains unclear. Our biomechanical study aimed to provide more data in this area by quantifying pressure distribution on the femoral head for normal and inverted hips and by determining the effects of labral inversion on pressure distribution across the joint, focusing on types of fracture under load.

Methods: We tested mid-sized fourth-generation composite femurs at 15° of adduction, and applied 1 mm/min of axial compressive force to the femoral heads until failure. Read More

View Article
December 2018
1 Read

A new classification for proximal femur bone defects in conservative hip arthroplasty revisions.

Int Orthop 2018 Dec 11. Epub 2018 Dec 11.

Orthopaedic and Traumatologic Department, Santo Spirito General Hospital, Rome, Italy.

Introduction: In the last three decades, total hip replacement in young patient became a habitual procedure. Principles of bone preservation are pushing many surgeons to implant conservative femoral components in patient younger than 65 years. Despite an overall good survivorship and clinical outcomes of conservative implants, failed cases are reported and the need to revise a conservative femoral component became an occasional procedure (with high prevalence of failed resurfacing implants). Read More

View Article
December 2018
1 Read

Femoral neck fractures in old age treated with hemiarthroplasty : Effects of preoperative waiting time and timing of surgery on the risk of periprosthetic infections.

Orthopade 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Traumatology and Plastic Surgery, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: Hemiarthroplasty is an established treatment for femoral neck fractures (FNF) in old age; however, approximately 20-30% of patients die within 1 year after surgery. Periprosthetic joint infections (PJI) are one of the severest complications and associated with a high mortality rate. In this retrospective study of aged patients with FNF treated with hemiarthroplasty, the incidence of PJI was evaluated with respect to the influence of the delay to and timing of surgical treatment. Read More

View Article
December 2018

Unusual bilateral ureter strangulation by fibrous tissue after perineal hernia repair in a dog.

Open Vet J 2018 19;8(4):441-444. Epub 2018 Nov 19.

Hokkaido University Veterinary Teaching Hospital, Kita 19, Nishi 10, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

A 10-year-old castrated male cross-breed dog was referred for the repair of perineal hernia with bladder retroflexion and a mass lesion in the hernial sac. Surgical treatment was performed and the mass was identified as degenerated adipose tissue that was suspected to be derived from the omentum. The hernial contents were reduced without difficulty, and the dog exhibited a normal recovery. Read More

View Article
November 2018

Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma.

Case Rep Oncol Med 2018 13;2018:1301562. Epub 2018 Nov 13.

Department of Ear, Nose, and Throat Disease, Bakırköy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Read More

View Article
November 2018

Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer.

Gastroenterol Res Pract 2018 12;2018:5428157. Epub 2018 Nov 12.

Department of Gastroenterology, Endoscopy Unit of the Cancer Institute of São Paulo-ICESP, Brazil.

Background: Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. It is not uncommon that PES is refractory to dilation sessions. This study aimed at evaluating the efficacy of Mitomycin C (MMC) endoscopic injection for the treatment of refractory pharyngoesophageal stenosis. Read More

View Article
November 2018

Functional and Structural Brain Plasticity in Adult Onset Single-Sided Deafness.

Front Hum Neurosci 2018 27;12:474. Epub 2018 Nov 27.

Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, United States.

Single-sided deafness (SSD) or profound unilateral hearing loss obligates the only serviceable ear to capture all acoustic information. This loss of binaural function taxes cognitive resources for accurate listening performance, especially under adverse environments or challenging tasks. We hypothesized that adults with SSD would manifest both functional and structural brain plasticity compared to controls with normal binaural hearing. Read More

View Article
November 2018

Pathophysiology of Subjective Tinnitus: Triggers and Maintenance.

Front Neurosci 2018 27;12:866. Epub 2018 Nov 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Tinnitus is the conscious perception of a sound without a corresponding external acoustic stimulus, usually described as a perception. One of the major challenges for tinnitus research is to understand the pathophysiological mechanisms triggering and maintaining the symptoms, especially for subjective chronic tinnitus. Our objective was to synthesize the published literature in order to provide a comprehensive update on theoretical and experimental advances and to identify further research and clinical directions. Read More

View Article
November 2018

Sound Change Integration Error: An Explanatory Model of Tinnitus.

Front Neurosci 2018 27;12:831. Epub 2018 Nov 27.

Department of Otolaryngology, Faculty of Medicine, Kindai University, Osakasayama, Japan.

A growing body of research is focused on identifying and understanding the neurophysiological mechanisms that underlie tinnitus. Unfortunately, however, most current models cannot adequately explain the majority of tinnitus features. For instance, although tinnitus generally appears within minutes after entering a silent environment, most models postulate that tinnitus emerges over a much larger timescale (days). Read More

View Article
November 2018

A comparison of neoadjuvant chemotherapy with gemcitabine versus docetaxel plus cisplatin in locoregionally advanced nasopharyngeal carcinoma: a propensity score matching analysis.

Cancer Manag Res 2018 23;10:6237-6245. Epub 2018 Nov 23.

Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China,

Purpose: To compare the efficacy and safety of neoadjuvant chemotherapy (NACT) with gemcitabine (GEM) vs docetaxel plus cisplatin (CDDP) in locoregionally advanced nasopharyngeal carcinoma (NPC).

Methods: A total of 222 patients with locoregionally advanced NPC between February 2012 and May 2014 in our hospital who received NACT with GEM or docetaxel plus CDDP combined with concurrent chemoradiotherapy (CCRT) were retrospectively analyzed. Fifty-two patients treated with GEM plus CDDP (GP) combined with CCRT were matched with 52 patients who received docetaxel plus CDDP (TP) combined with CCRT. Read More

View Article
November 2018

Radiotherapy as salvage treatment of salivary duct carcinoma in major salivary glands without radical operations.

Cancer Manag Res 2018 21;10:6071-6078. Epub 2018 Nov 21.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China,

Background: Salivary duct carcinoma (SDC) is an extremely rare and highly malignant carcinoma, and surgical radical resection is the most effective therapy. However, there were quite a proportion of patients receiving non-radical resections, and how to treat them remained controversial. Thus, the aim of this study is to evaluate whether postoperative radiotherapy could be a salvage treatment of SDC in major salivary glands without radical operations. Read More

View Article
November 2018

Madelung's disease - progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review.

Diabetes Metab Syndr Obes 2018 26;11:819-825. Epub 2018 Nov 26.

Department of Surgery with Trauma, Orthopaedic and Urological Subunit, Independent Public Health Care Center of the Ministry of Interior and Administration in Lublin, Lublin, Poland,

Madelung's disease is a rare disorder described for the first time in the year 1846 by Brodie. It is characterized by the occurrence of progressive, excessive, and symmetrical deposits of adipose tissue in the subcutaneous layer. Most often, these changes concern the neck, the nape of the neck, arms, and upper back, giving the patients a specific, pseudoathletic appearance. Read More

View Article
November 2018

Biomimetic intrafibrillar mineralized collagen promotes bone regeneration via activation of the Wnt signaling pathway.

Int J Nanomedicine 2018 21;13:7503-7516. Epub 2018 Nov 21.

Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research, Institute of Stomatology and National Clinical Research Center of Stomatology, Shanghai, China,

Purpose: The purpose of this study was to assess the effects of biomimetic intrafibrillar mineralized collagen (IMC) bone scaffold materials on bone regeneration and the underlying biological mechanisms.

Materials And Methods: A critical-sized bone defect in the rat femur was created; then IMC, extrafibrillar mineralized collagen, and nano-hydroxyapatite bone scaffold materials were grafted into the defect. Ten weeks after implantation, micro-computed tomography and histology were applied to evaluate the bone regeneration. Read More

View Article
November 2018

Malignant Peripheral Nerve Sheath Tumor of the Parotid Gland.

Indian J Surg Oncol 2018 Dec 16;9(4):629-632. Epub 2018 May 16.

1Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Rohini, New Delhi, India.

Malignant peripheral nerve sheath tumor (MPNST) refers to spindle cell sarcomas arising from or separating in the direction of cells of peripheral nerve sheath. The MPNST of the parotid gland is an extremely rare tumor, accounts for < 5% of all soft tissue sarcomas, and carries a poor prognosis. In this article, we report a case of MPNST of parotid gland in a 45-year-old male and review its diagnostic and therapeutic challenges. Read More

View Article
December 2018