524 results match your criteria Neck Cancer Unknown Primary Site


Prostate Cancer Metastasis To Cervical Node Chain-An Unusual Clinic-Pathological Finding.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):134-135

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Prostate carcinoma is one of the most common cancers in males all around the world. Head and neck squamous cell carcinoma is amongst the leading carcinoma (HNSCC) in men especially in the sub-continent. There are around 150 lymph nodes on either side in the neck and cervical lymph nodes are a common site for head and neck malignancies to metastasize however carcinoma of prostate may in rare cases metastasize to cervical chain, therefore warranting a neck dissection. Read More

View Article

Download full-text PDF

Source
March 2019
1 Read

Unknown primary of the head and neck: a new entry in the TNM staging system with old dilemmas for everyday practice.

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):73-79

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS National Cancer Institute of Milan.

Purpose Of Review: To summarize the most recent nuances in diagnosis, management, and prognostic stratification of carcinoma of unknown primary of the head and neck (CUPHN), in light of its recent re-assessment in the eighth edition of the TNM Classification Manual.

Recent Findings: At least in Western Countries, most CUPHN are expected to be Human Papilloma Virus (HPV)-positive with an oropharyngeal origin. Their appropriate diagnosis starts with fine needle aspiration cytology and/or core biopsy of pathologic lymph node(s) with staining for p16 by immunohistochemistry and subsequent HPV detection by PCR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOO.0000000000000528DOI Listing
April 2019
2 Reads

Morbidity and mortality among patients with head and neck cancer in the emergency department: A national perspective.

Head Neck 2019 Apr 24;41(4):1007-1015. Epub 2019 Jan 24.

Center for Global Surgery Evaluation, Massachusetts Eye and Ear, Boston, Massachusetts.

Background: Emergency departments are playing an increasing role in cancer management. Emergency department utilization by patients with head and neck cancer, however, is unknown.

Methods: The 2009-2011 Nationwide Emergency Department Sample was queried for patients with a principle diagnosis of head and neck cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25534DOI Listing
April 2019
4 Reads

Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site.

Head Neck 2019 Jan 11. Epub 2019 Jan 11.

Department of Anatomic Pathology, University of California San Francisco, San Francisco, California.

Background: Head and neck squamous cell carcinoma of unknown primary site (HNSCCUP) is a diagnostic challenge. Identification of an ultraviolet (UV) light-related DNA damage signature using next-generation sequencing (NGS) can classify the primary site of origin as cutaneous.

Methods: A 62-year-old male was seen with 2 months of left neck swelling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25613DOI Listing
January 2019
9 Reads

Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Oral Oncol 2019 Jan 30;88:145-152. Epub 2018 Nov 30.

Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2018.11.020DOI Listing
January 2019
2 Reads

The Impact of a Stepwise Approach to Primary Tumor Detection in Squamous Cell Carcinoma of the Neck With Unknown Primary.

Laryngoscope 2018 Nov 22. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland, U.S.A.

Objectives/hypothesis: To examine the cumulative effect of diagnostic steps for primary tumor identification in patients with head and neck squamous cell carcinoma of unknown primary (HNSCCUP), including lingual tonsillectomy, and the impact of primary tumor identification on subsequent treatment.

Study Design: Retrospective analysis.

Methods: We reviewed the records of 110 patients diagnosed with HNSCCUP between 2003 and 2015. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/lary.27625
Publisher Site
http://dx.doi.org/10.1002/lary.27625DOI Listing
November 2018
9 Reads

Treatment outcomes of squamous cell carcinoma of the oral cavity in young adults.

Oral Oncol 2018 Dec 22;87:43-48. Epub 2018 Oct 22.

Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, AZ, United States. Electronic address:

Objectives: The natural history of squamous cell carcinoma (SCC) of the oral cavity (OC) in young adults is unknown. We sought to provide an updated report on treatment outcomes of patients with OC SCC who were 40 years or younger.

Materials And Methods: We performed a retrospective analysis of 124 consecutive patients with primary OC SCC treated at Mayo Clinic (1980-2014). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2018.10.014DOI Listing
December 2018
2 Reads

HPV-associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity.

Cancer Cytopathol 2019 Feb 26;127(1):26-34. Epub 2018 Nov 26.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: The majority of human papillomavirus (HPV)-associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV-associated neuroendocrine carcinomas (HPV-NECs) in the upper aerodigestive tract. The aim of this study was to characterize the diagnostic features of fine-needle aspiration (FNA) cases of head and neck HPV-NEC.

Methods: Cytology cases of HPV-NEC were identified over a 3-year period from 2 institutions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncy.22075DOI Listing
February 2019
1 Read

Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique.

J Laryngol Otol 2018 Dec 20;132(12):1138-1142. Epub 2018 Nov 20.

Department of ENT, Head and Neck Surgery,Royal Sussex County Hospital,Brighton, and Head and Neck Unit,Queen Victoria Hospital,East Grinstead,UK.

Background: Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0022215118002062DOI Listing
December 2018
23 Reads

Palatine tonsil SUVmax on FDG PET-CT as a discriminator between benign and malignant tonsils in patients with and without head and neck squamous cell carcinoma of unknown primary.

Clin Radiol 2019 Feb 16;74(2):165.e17-165.e23. Epub 2018 Nov 16.

King's College London and St Guy's and St Thomas' PET Centre, London, UK.

Aim: To analyse the maximum standardised uptake value (SUVmax) ratio between tonsils in patients with and without tonsillar carcinoma to determine useful diagnostic thresholds.

Materials And Methods: Positron-emission tomography (PET)/computed tomography (CT) examinations of patients with suspected head and neck squamous cell carcinoma (SCC) and controls from April 2013 to September 2016 were reviewed retrospectively. Tonsillar SUVmax ratios (ipsilateral/contralateral for malignant tonsils, maximum/minimum for patients without [controls]) were calculated and used to construct a receiver operating characteristic (ROC) curve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crad.2018.10.007DOI Listing
February 2019
1 Read

Endobronchial ultrasound-guided transbronchial needle aspiration cytology in patients with known or suspected extra-pulmonary malignancies: A cytopathology-based study.

Cytopathology 2019 Jan 21;30(1):82-90. Epub 2018 Dec 21.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM).

Methods: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cyt.12656DOI Listing
January 2019
5 Reads
1.481 Impact Factor

ROS1-rearranged putative lung adenocarcinoma presenting as carcinoma of unknown primary site: a case report.

Oncotarget 2018 Oct 16;9(81):35278-35282. Epub 2018 Oct 16.

Department of Molecular and Internal Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.

Carcinoma of unknown primary site (CUP) is diagnosed only in 2-9% of all cancer cases. Adenocarcinomas account for approximately 60% of CUP, and some of these are putative lung adenocarcinomas. The frequency of driver oncogene positivity in the putative lung adenocarcinomas is unknown, and the efficacy of targeting therapies for the driver oncogene is also unknown. Read More

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/26233
Publisher Site
http://dx.doi.org/10.18632/oncotarget.26233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219662PMC
October 2018
8 Reads

Transoral Robotic Surgery and the Unknown Primary.

ORL J Otorhinolaryngol Relat Spec 2018 12;80(3-4):148-155. Epub 2018 Nov 12.

University of Pittsburgh, Department of Otolaryngology, Eye & Ear Institute, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA.

Carcinoma of unknown primary (CUP) comprises approximately 1%-5% of all head and neck malignancies. Primary site detection rates for metastatic cervical squamous cell carcinoma (SCC) remain variable, with current diagnostic imaging unable to identify all tumours. Prevailing evidence suggests that most head and neck CUP are located in the oropharynx. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/490596
Publisher Site
http://dx.doi.org/10.1159/000490596DOI Listing
November 2018
10 Reads

Incisional Seeding of Metastatic Squamous Cell Carcinoma Following Carotid Endarterectomy: An Unusual Case of an Unknown Primary Cancer Presenting as a Presumed Neck Abscess.

Oper Neurosurg (Hagerstown) 2018 Nov 10. Epub 2018 Nov 10.

Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.

Background: Carotid endarterectomy (CEA) is a safe and effective procedure, with a low risk of complications when performed by experienced surgeons. Postoperative infections are particularly rare, reportedly affecting less than 1% of cases. Incisional metastases have not been described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ons/opy335DOI Listing
November 2018
4 Reads

Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma.

Laryngoscope 2018 11 8;128(11):2573-2575. Epub 2018 Sep 8.

Department of Facial Plastic and Reconstructive Surgery , Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, U.S.A.

Objectives/hypothesis: With positron emission tomography/computed tomography (PET/CT) now commonplace as a diagnostic tool, new questions have arisen regarding the utility and cost-effectiveness of panendoscopy. In this retrospective review of a large cohort of head and neck squamous cell carcinoma of unknown primary (HNSCC-UP), we describe the enduring utility of panendoscopy in the detection of the primary site of mucosal disease even when PET/CT is negative.

Study Design: Retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lary.27268DOI Listing
November 2018
15 Reads

Causes for delay before specialist consultation in head and neck cancer.

Acta Oncol 2018 Dec 24;57(12):1677-1686. Epub 2018 Aug 24.

a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Background: Head and neck cancers are often diagnosed at a late stage, thus resulting in a generally poor prognosis. This is partly attributable to patients' hesitancy in seeking treatment. However, the length and causes of these patient delays remain relatively unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/0284186X.2018.1497297DOI Listing
December 2018
18 Reads

Treatment of Clinically Positive Cervical Lymph Nodes by Limited Local Node Excision and Adjuvant Radiotherapy in Melanoma Patients with Major Comorbidities.

Ann Surg Oncol 2018 Nov 16;25(12):3476-3482. Epub 2018 Aug 16.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.

Introduction: When cervical lymph nodes are clinically positive for metastatic melanoma, surgeons may be hesitant to recommend a therapeutic complete lymph node dissection if the patient is elderly or has major comorbidities. A limited local node excision of the clinically positive nodes only, followed by adjuvant radiotherapy to the entire node field, may be an effective alternative in such patients.

Methods: All patients who had presented with a primary head and neck melanoma or an unknown primary site and had subsequently undergone limited local node excision and adjuvant radiotherapy for macroscopically involved cervical nodes between 1993 and 2010 at a tertiary referral center were selected for study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1245/s10434-018-6692-2
Publisher Site
http://dx.doi.org/10.1245/s10434-018-6692-2DOI Listing
November 2018
14 Reads

Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience.

South Asian J Cancer 2018 Jul-Sep;7(3):207-209

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Background: Neuroendocrine carcinoma (NEC) is a rare tumor arising from the diffuse neuroendocrine system. Most of these present in the advanced stage and palliative chemotherapy remains the only option. The prognosis remains poor with the standard chemotherapy regimen of platinum and etoposide (EP) providing modest survival benefit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/sajc.sajc_176_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069343PMC
August 2018
2 Reads

Post-treatment sequelae and management of primary laryngeal NK/T-cell lymphoma: A case report.

Am J Otolaryngol 2018 Nov - Dec;39(6):781-784. Epub 2018 Jul 25.

Cleveland Clinic, 9500 Euclid Ave, A-71, Cleveland, OH 44195, United States of America. Electronic address:

Outcome Objectives: METHODS: Case Report, April 2016.

Results: A 27-year-old female presented with a three-week history of flu-like symptoms including sore throat, myalgia and insidious nasal congestion. Her hospital course was complicated by pancytopenia, extensive GI bleed of unknown origin and fever. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjoto.2018.07.017DOI Listing
February 2019
5 Reads

Functional considerations in oral cavity reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2018 Oct;26(5):326-333

Massachusetts Eye and Ear Infirmary, Harvard School of Medicine, Boston, Massachusetts, USA.

Purpose Of Review: The treatment of oral cavity cancer may impair speech and swallowing function. Optimizing posttreatment function may lead to significant improvement of quality of life.

Recent Findings: Although oncologic control remains the main goal of treatment for oral cavity cancer, posttreatment function for surviving patients has over the last decades been recognized as an important secondary outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOO.0000000000000474DOI Listing
October 2018
21 Reads

Diagnostic lymph node extirpation in CUP syndrome - useful or damaging?

Acta Otolaryngol 2018 Oct 17;138(10):926-929. Epub 2018 Jul 17.

a Department of Otorhinolaryngology , Klinikum rechts der Isar der Technischen Universitat Muenchen , Munich , Germany.

Objective: In a proportion of patients with cervical lymph node metastasis no primary can be found even with modern imaging and careful clinical examination (cancer of unknown primary syndrome = CUP syndrome). The ideal diagnostic approach is still debated on.

Methods: The clinical data of 75 patients (median age: 61. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00016489.2018.1484563DOI Listing
October 2018
6 Reads

An evaluation of the diagnostic methods in head and neck cancer of unknown primary site.

Acta Otolaryngol 2018 Oct 17;138(10):930-936. Epub 2018 Jul 17.

a Department of Otorhinolaryngology - Head and Neck Surgery , Helsinki University Central Hospital , Helsinki , Finland.

Background: Various detection methods to identify the primary in head and neck cancer of unknown primary (HN-CUP) require evaluation to improve and standardize management.

Objectives: To evaluate the use of different diagnostic methods, which aim at decreasing the incidence of HN-CUP.

Material And Methods: We conducted a retrospective analysis of patients with HN-CUP at the Helsinki University Hospital during 1995-2011. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00016489.2018.1484567DOI Listing
October 2018
14 Reads

Diagnostic accuracy of contrast-enhanced computed tomography for assessment of mandibular and medial retropharyngeal lymph node metastasis in dogs with oral and nasal cancer.

Vet Comp Oncol 2018 Dec 10;16(4):562-570. Epub 2018 Jul 10.

Department of Small Animal Clinical Sciences, University of Florida, Gainesville, Florida.

The diagnostic accuracy of contrast-enhanced CT for detection of cervical lymph node metastasis in dogs is unknown. The purpose of this retrospective, observational, diagnostic accuracy study was to assess the efficacy of CT for detection of mandibular and medial retropharyngeal lymph node metastasis in dogs. Histopathology of dogs with cancer of the head, CT and bilateral mandibular and medial retropharyngeal lymphadenectomy was reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vco.12415DOI Listing
December 2018
2 Reads

[Clinical significance of four quadrant localization in the diagnosis and treatment of metastatic carcinoma of the neck with unknown primary].

Authors:
Y Y Gao X H Chen

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;31(11):858-862

Department of Otolaryngology Head and Neck Surgery, Affiliated Beijing Tongren Hospital of Capital Medical University.

The aim of this study is to investigate the clinical significance of four quadrant localization in the diagnosis and treatment of unknown primary cervical metastases. The clinical data with unknown primary cervical metastases, were analyzed retrospectively. All the patients have not been found the original site in the initial treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.13201/j.issn.1001-1781.2017.11.010DOI Listing

Patterns of care analysis for head & neck cancer of unknown primary site: a survey inside the German society of radiation oncology (DEGRO).

Strahlenther Onkol 2018 Aug 14;194(8):750-758. Epub 2018 May 14.

Department of Radiation Oncology, University Hospital Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

Background: Due to the absence of randomized trials, the optimal management for squamous cell cancer of unknown primary in the head and neck region (SCCHN CUP) remains controversial. Current strategies are based on retrospective studies, clinical experience, and institutional policies.

Methods: An anonymous questionnaire with a total of 24 questions was created and distributed by the use of an online version (Google Forms®, Google, Mountain View, CA, USA) as well as a printout version as equivalent option. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00066-018-1308-0
Publisher Site
http://dx.doi.org/10.1007/s00066-018-1308-0DOI Listing
August 2018
8 Reads

Lingual Tonsillectomy Likely Does Not Improve Outcomes for Squamous Cell Carcinoma of the Head and Neck From an Unknown Primary Site.

Am J Clin Oncol 2018 Dec;41(12):1216-1219

Departments of Radiation Oncology.

Objective: Patients with mucosal squamous cell carcinoma (SCC) of the head and neck almost always have a primary site in the base of tongue or tonsillar fossa. Lingual tonsillectomy has recently been advocated as part of the diagnostic evaluation as opposed to directed biopsies of the base of tongue and thought to possibly result in an increased likelihood or cure. The purpose of this project is to determine whether this is probable. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00000421-201812000-0001
Publisher Site
http://dx.doi.org/10.1097/COC.0000000000000461DOI Listing
December 2018
8 Reads

Cutaneous and Subcutaneous Metastases of Adenocarcinoma as a Dominant Clinical Manifestation of Malignancy of Unknown Origin - a Case Report.

Klin Onkol 2018 ;31(2):143-147

Background: Cutaneous metastases occur in 0.6-10.4% of all patients with underlying malignancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14735/amko2018143DOI Listing
January 2018
2 Reads

Ethnic disparity in primary cutaneous CD30 T-cell lymphoproliferative disorders: an analysis of 1496 cases from the US National Cancer Database.

Br J Haematol 2018 06 20;181(6):752-759. Epub 2018 Apr 20.

The Second Xiangya Hospital, Central South University, Department of Dermatology, Changsha, Hunan, China.

Primary cutaneous CD30 T cell lymphoproliferative disorders (PCLPD), the second most common type of primary cutaneous T cell lymphomas, accounts for approximately 25-30% of cutaneous T-cell lymphoma cases. However, only small retrospective studies have been reported. We aimed to identify prognostic factors and evaluate the overall survival (OS) of patients with PCLPD stratified by ethnicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15222DOI Listing
June 2018
13 Reads

NUT Carcinoma of the Salivary Glands: Clinicopathologic and Molecular Analysis of 3 Cases and a Survey of NUT Expression in Salivary Gland Carcinomas.

Am J Surg Pathol 2018 Jul;42(7):877-884

Sarcoma Unit/Head and Neck Unit.

NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the NUT (aka NUTM1, nuclear protein in testis) gene, most commonly fused to BRD4. Originally described as a mediastinal/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010176PMC
July 2018
3 Reads

Cervical lymph node carcinoma metastasis from unknown primary site: a retrospective analysis of 154 patients.

Cancer Med 2018 May 2;7(5):1852-1859. Epub 2018 Apr 2.

Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Despite advances in diagnosis and treatment, the existence of cervical lymph node carcinoma of unknown primary site (CCUP) has always been an urgent problem worldwide. There is still no consensus on the optimal management for CCUP. In this retrospective review, we analyze the clinical characteristics of CCUP patients treated at our institution and examine how these characteristics and treatments were associated with survival. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cam4.1458
Publisher Site
http://dx.doi.org/10.1002/cam4.1458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943546PMC
May 2018
8 Reads

The comparison of acute toxicity in 2 treatment courses: Three-weekly and weekly cisplatin treatment administered with radiotherapy in patients with head and neck squamous cell carcinoma.

Medicine (Baltimore) 2017 Dec;96(51):e9151

Radiotherapy Department II Greater Poland Cancer Center.

The most appropriate cisplatin treatment schedule delivered with radiotherapy in patients with head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to compare the acute toxicity and its impact on the course of the treatment, administered cisplatin and radiation doses, the length of hospitalization and supportive drugs administration in patients with HNSCC receiving 2 different cisplatin treatment schedules administered with radiotherapy.In this retrospective analysis, 104 patients with HNSCC were enrolled. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00005792-201712220-0003
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000009151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758147PMC
December 2017
10 Reads

Head and neck squamous cell carcinoma of unknown primary: Outcomes of a pre-defined institutional treatment policy in a region with a high prevalence of skin cancer.

Oral Oncol 2018 Feb 20;77:43-48. Epub 2017 Dec 20.

Department of Radiation Oncology, Princess Alexandra Hospital, Brisbane, Queensland, Australia; The University of Queensland, Queensland, Australia.

Objectives: To determine the rate of subsequent primary site failure in patients with head and neck squamous cell carcinoma of unknown primary (UKP HNSCC) in a region with a high prevalence of cutaneous squamous cell carcinoma, according to a pre-determined institutional policy. Secondary aims included regional and distant control, and overall survival.

Material And Methods: Patients presenting between April 2005 and June 2016 to the Princess Alexandra Hospital Head and Neck Multidisciplinary Meeting with UKP HNSCC from either presumed mucosal or cutaneous sites treated with curative intent were eligible. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13688375173041
Publisher Site
http://dx.doi.org/10.1016/j.oraloncology.2017.12.011DOI Listing
February 2018
7 Reads

Comparative study of lung and extrapulmonary poorly differentiated neuroendocrine carcinomas: A SEER database analysis of 162,983 cases.

Cancer 2018 Feb 6;124(4):807-815. Epub 2017 Dec 6.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Extrapulmonary neuroendocrine carcinomas (NECs) are poorly studied and are managed similar to lung NECs, which may not account for differences between the 2 groups of tumors as well as the heterogeneity within extrapulmonary NEC.

Methods: Data from the Surveillance, Epidemiology, and End Results program between 1973 and 2012 were used to estimate the relative percentages of lung NECs and subgroups of extrapulmonary NECs, epidemiological patterns at these sites, and the median and 5-year overall survival rates.

Results: Of 162,983 NEC cases, 14,732 were extrapulmonary; of these, 5509 were gastrointestinal (37. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/cncr.31124
Publisher Site
http://dx.doi.org/10.1002/cncr.31124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801102PMC
February 2018
9 Reads

Diagnosis and management of metastatic neoplasms with unknown primary.

Semin Diagn Pathol 2018 May 26;35(3):199-206. Epub 2017 Nov 26.

Clinical Cooperation Unit Molecular Hematology / Oncology, German Cancer Research Center (DKFZ) and Department of Medicine V, University of Heidelberg, Heidelberg, Germany; Department of Internal Medicine V, Hematology / Oncology, University of Heidelberg, Heidelberg, Germany. Electronic address:

In cancer of unknown primary (CUP), metastases are clinically and histologically confirmed, but the primary tumor site remains elusive after extensive work-up. CUPs make up for 2-3% of all epithelial malignancies. The two prevailing histologies are adenocarcinomas and undifferentiated carcinomas, whereas squamous cell carcinomas, neuroendocrine carcinomas and rare histologies account for the remaining 10%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.semdp.2017.11.013DOI Listing
May 2018
9 Reads

AHNS Series: Do you know your guidelines? Guideline recommendations for head and neck cancer of unknown primary site.

Head Neck 2018 03 21;40(3):614-621. Epub 2017 Nov 21.

Department of Otolaryngology - Head and Neck Surgery, Division of Head and Neck Oncology, Ohio State University, James Cancer Centre and Solove Research Institute, Columbus, Ohio.

This article reviews the clinical practice guidelines for head and neck oncology focusing on the management of head and neck cancers of unknown primary (CUP). The primary purpose of this series is to raise awareness of the current guidelines in head and neck oncology by reviewing the recommendations and the evidence supporting such recommendations, particularly those published by the National Comprehensive Cancer Network (NCCN). We review the importance of a thorough history and physical examination, the impact of the American Joint Committee on Cancer (AJCC) eighth edition changes and the importance of immunohistochemistry, the timing and type of imaging, the role of panendoscopy and tonsillectomy (palatine and lingual), and the role of surgery, radiation, and chemotherapy in the primary management of these tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.25026DOI Listing
March 2018
11 Reads

Multilayered Omics-Based Analysis of a Head and Neck Cancer Model of Cisplatin Resistance Reveals Intratumoral Heterogeneity and Treatment-Induced Clonal Selection.

Clin Cancer Res 2018 01 23;24(1):158-168. Epub 2017 Oct 23.

Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiooncology and Radiotherapy, Berlin, Germany.

Platinum-based drugs, in particular cisplatin (cis-diamminedichloridoplatinum(II), CDDP), are used for treatment of squamous cell carcinoma of the head and neck (SCCHN). Despite initial responses, CDDP treatment often results in chemoresistance, leading to therapeutic failure. The role of primary resistance at subclonal level and treatment-induced clonal selection in the development of CDDP resistance remains unknown. Read More

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-17-2410DOI Listing
January 2018
8 Reads

Post-operative therapy following transoral robotic surgery for unknown primary cancers of the head and neck.

Oral Oncol 2017 09 25;72:150-156. Epub 2017 Jul 25.

Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, United States; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States. Electronic address:

Objectives: Our primary objective is to describe the post- operative management in patients with an unknown primary squamous cell carcinoma of the head and neck (HNSCC) treated with trans-oral robotic surgery (TORS).

Materials & Methods: We conducted a retrospective multi-institutional case series including all patients diagnosed with an unknown primary HNSCC who underwent TORS to identify the primary site from January 1, 2010 to June 30, 2016. We excluded those with recurrent disease, ≤6months of follow up from TORS, previous history of radiation therapy (RT) to the head and neck, or evidence of primary tumor site based on previous biopsies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2017.07.019DOI Listing
September 2017
41 Reads

Characteristics and long-term outcomes of head and neck squamous cell carcinoma after solid organ transplantation.

Oral Oncol 2017 09 17;72:104-109. Epub 2017 Jul 17.

Division of Medical Oncology, Mayo Clinic, Rochester, MN, United States.

Introduction: Immunosuppression after solid organ transplant prevents graft rejection, but leads to increased incidence of various malignancies including head and neck squamous cell carcinoma (HNSCC). Outcomes of patients with post-transplant HNSCC are unknown.

Materials And Methods: We retrospectively identified patients who developed HNSCC after solid organ transplant between 1995 and 2010. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2017.07.010DOI Listing
September 2017
13 Reads

Role of FDG PET/CT Scan in Head and Neck Cancer Patients.

Arch Iran Med 2017 07;20(7):452-458

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: PET/CT scan has an emerging role in head and neck oncology with a few well-established indications, including: detection of unknown primary tumor site, tumor staging, radiotherapy planning, treatment response assessment and detection of recurrent disease. The purpose of this study is reporting PET/CT findings in head and neck cancer patients to emphasize its role in head and neck oncology.

Materials And Methods: In a retrospective study, we reviewed our PET/CT database and found 94 patients with primary head and neck cancer. Read More

View Article

Download full-text PDF

Source
July 2017
12 Reads

Neck dissection for unknown cancer of the head and neck in the era of chemoradiation.

Am J Otolaryngol 2017 Sep - Oct;38(5):588-592. Epub 2017 Jun 14.

Department of Radiation Oncology, University of Louisville School of Medicine, Louisville, KY, USA.

Purpose: To report outcomes for patients with cervical lymph node metastases from an unknown primary site of the head and neck treated with either non-operative therapy or neck dissection followed by adjuvant therapy.

Materials And Methods: All patients with squamous cell carcinoma of an unknown primary site of the head or neck seen between 2003 and 2013 were reviewed. The Kaplan-Meier method was used to estimate overall survival, local recurrence free survival, loco-regional recurrence free survival, and progression free survival. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01960709173024
Publisher Site
http://dx.doi.org/10.1016/j.amjoto.2017.06.006DOI Listing
June 2018
6 Reads

Five-year outcomes of an oropharynx-directed treatment approach for unknown primary of the head and neck.

Oral Oncol 2017 07 13;70:14-22. Epub 2017 May 13.

Dept of Radiation Oncology, Moffitt Comprehensive Cancer Center, Tampa, FL, United States.

Purpose: Squamous cell carcinoma of unknown primary (SCCHNUP) is commonly treated with comprehensive radiation to the laryngopharynx and bilateral necks. In 1998, we established a departmental policy to treat SCCHNUP with radiation directed to the oropharynx and bilateral neck.

Methods: From 1998-2011, 60 patients were treated - N1: 18%, N2: 75% and N3: 7%. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2017.05.001DOI Listing
July 2017
32 Reads

Diagnostic and treatment modalities for patients with cervical lymph node metastases of unknown primary site - current status and challenges.

Radiat Oncol 2017 May 10;12(1):82. Epub 2017 May 10.

Department of Radiation Oncology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

Background And Purpose: This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown primary (CUP).

Methods: A literature search for head and neck CUP was performed with focus on diagnostics and therapies as well as molecular markers.

Results: High level evidence on CUP is limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13014-017-0817-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424363PMC
May 2017
9 Reads

Management delays in patients with squamous cell cancer of neck node(s) and unknown primary site: a retrospective cohort study.

J Otolaryngol Head Neck Surg 2017 May 8;46(1):39. Epub 2017 May 8.

Division of Radiation Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada.

Background: We aim to characterize the workup received by and identify any delays to diagnosis or treatment in patients referred to a tertiary cancer centre with the diagnosis of squamous cell carcinoma in neck node(s) and no identifiable primary (SCCNIP).

Methods: Over 1 year, 68 patients were initially referred to the Head and Neck clinic with a label of "primary unknown". After extensive workup, 29 of the 68 patients were found to have pathologically confirmed SCCNIP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40463-017-0217-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422917PMC
May 2017
29 Reads

Treatment for retropharyngeal metastatic undifferentiated squamous cell carcinoma from an unknown primary site: results of a prospective study with irradiation to nasopharyngeal mucosa plus bilateral neck.

Oncotarget 2017 Jun;8(26):42372-42381

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.

Background and Objetive: To evaluate treatment outcomes for patients with retropharyngeal metastatic undifferentiated squamous cell carcinoma (SCC) from an unknown primary site.

Methods: From January 2005 to January 2015, patients who presented with enlarged retropharyngeal nodes underwent transoral sonography-guided fine-needle aspiration to confirm histology. Those with metastatic undifferentiated SCC with unknown primary tumors were treated with radical radiotherapy to nasopharyngeal mucosa plus bilateral neck. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.16344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522073PMC
June 2017
5 Reads

Trans-oral robotic assisted tongue base mucosectomy for investigation of cancer of unknown primary in the head and neck region. The UK experience.

Clin Otolaryngol 2017 Dec 26;42(6):1247-1251. Epub 2017 Mar 26.

Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.

Objectives: The diagnosis of cancer of unknown primary (CUP) in head and neck occurs when the treating clinicians have utilised all available diagnostic tests and failed to identify the origin of the disease. There is no agreed consensus on which diagnostic investigations to use, or the order in which to use them in, although broad recommendations exist. Small tumours arising in the tongue base can be below the limits of resolution of conventional diagnostic techniques. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/coa.12860
Publisher Site
http://dx.doi.org/10.1111/coa.12860DOI Listing
December 2017
13 Reads

The role of transoral robotic surgery in the management of oropharyngeal cancer.

Curr Opin Oncol 2017 Mar 1. Epub 2017 Mar 1.

aHead and Neck Surgery Service, Brazilian National Cancer Institute (INCA), Department of Head and Neck Surgery, Post Graduate School of Medicine, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro bDepartment of Otolaryngology and Head and Neck Surgery, Escola Paulista de Medicina (EPM), Federal University of São Paulo (UNIFESP), São Paulo, Brazil.

Purpose Of Review: The rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), in large part as a result of the human papillomavirus (HPV), has driven a movement for the change in the management strategies. Renewed interest in minimally invasive approaches of endoscopic head and neck surgery led to introduction of transoral surgery, including transoral robotic surgery (TORS).

Recent Findings: Several recent studies, based on large multi-institutional studies and systematic reviews of the literature, have shown excellent oncologic and functional outcomes with TORS for OPSCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCO.0000000000000365DOI Listing
March 2017
9 Reads

Transoral robotic surgery for management of cervical unknown primary squamous cell carcinoma: Updates on efficacy, surgical technique and margin status.

Oral Oncol 2017 03 6;66:9-13. Epub 2017 Jan 6.

UPMC Department of Otolaryngology/Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

Importance: Management of cervical unknown primary squamous cell carcinoma (CUP) has evolved with the introduction of transoral robotic surgery (TORS).

Objectives: 1. To describe the efficacy of TORS lingual and palatine tonsillectomy in identifying the primary site of malignancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2016.12.033DOI Listing
March 2017
26 Reads

Combined p16 and p53 expression in cervical cancer of unknown primary and other prognostic parameters : A single-center analysis.

Strahlenther Onkol 2017 Apr 31;193(4):305-314. Epub 2017 Jan 31.

Department of Radiation Oncology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590, Frankfurt, Germany.

Background And Purpose: Cervical cancer of unknown primary (CUP) represents an uncommon and heterogeneous subentity of head and neck cancer. However, both optimal diagnostics and therapy remain unclear. An improved understanding of the underlying pathology is essential to enable future tailored therapies and optimized outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00066-017-1102-4DOI Listing
April 2017
5 Reads

Extensive Regional Metastasis of High-Grade Mucoepidermoid Carcinoma of an Unknown Primary Tumor.

J Oral Maxillofac Surg 2017 Apr 15;75(4):874.e1-874.e7. Epub 2016 Dec 15.

Chairman and Professor, Department of Oral and Maxillofacial Surgery, University of Maryland School of Dentistry, University of Maryland Medical Center, Baltimore, MD.

Purpose: Mucoepidermoid carcinoma (MEC) is the most common salivary carcinoma. It arises most frequently in the major salivary glands, but can also arise in minor glands or intraosseous sites. MEC of an unknown primary occurs very rarely. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2016.12.012DOI Listing
April 2017
5 Reads

Transoral Robotic Surgery-Assisted Endoscopy With Primary Site Detection and Treatment in Occult Mucosal Primaries.

JAMA Otolaryngol Head Neck Surg 2017 03;143(3):267-273

Department of Otorhinolaryngology-Head & Neck Surgery, University of Pennsylvania School of Medicine, Philadelphia.

Importance: Management of cervical lymph node metastasis without a known primary tumor is a diagnostic and treatment challenge for head and neck oncologists. Identification of the occult mucosal primary tumor minimizes the morbidity of treatment.

Objective: To analyze the role of transoral robotic surgery (TORS) in facilitating the identification of a primary tumor site for patients presenting with squamous cell carcinoma of unknown primary (CUP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoto.2016.3419DOI Listing
March 2017
14 Reads