556 results match your criteria Neck Cancer Unknown Primary Site


Carcinoma of unknown primary detected by whole-body diffusion-weighted imaging: A case report and review of the literature.

Radiol Case Rep 2020 Jul 12;15(7):983-987. Epub 2020 May 12.

Department of Radiology, Daping hospital, Army medical university, Chongqing 400042, China.

Carcinoma of unknown primary accounts for 2%-5% of all head and neck tumors. Identification of the primary site is challenging. We present a case report of a 43-year-old man with metastatic cervical lymphadenopathy for 3 year, and the primary tumor was unknown after routine examinations, including positron emission tomography/computed tomography. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225598PMC

Radiotherapeutic management of cervical lymph node metastases from an unknown primary site - experiences from a large cohort treated with modern radiation techniques.

Radiat Oncol 2020 Apr 15;15(1):80. Epub 2020 Apr 15.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Robert-Koch-Str. 3, 79106, Freiburg, Germany.

Purpose: To analyze management and outcomes following (chemo)radiation therapy in patients with cervical lymph node metastases from an unknown primary site (CCUP) in a large single-center cohort.

Methods: Between 2008 and 2019, 58 patients with CCUP were treated with (chemo)radiation therapy at the University of Freiburg Medical Center and were included in this analysis. Overall survival (OS), locoregional progression-free survival (PFS) and distant metastasis-free survival (DMFS) were calculated using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.1186/s13014-020-01529-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158130PMC

The role of tumour morphology in assigning HPV status in oropharyngeal squamous cell carcinoma.

Oral Oncol 2020 Jun 10;105:104670. Epub 2020 Apr 10.

Department of Pathology, Cork University Hospital, Wilton, Cork, Ireland; ENTO Research Unit, College of Medicine and Health, University College Cork, College Road, Cork, Ireland. Electronic address:

Objectives: There is no consensus on the optimal approach to human papilloma virus (HPV) testing in oropharyngeal squamous cell carcinoma (OPSCC). Our objective was to classify OPSCC as HPV positive or negative based on (1) morphology alone, (2) p16 status alone, (3) combined morphology and p16 status with additional HPV testing in discordant cases in keeping with 2012 College of American Pathologists (CAP) guidelines (combined approach), and to evaluate and compare survival outcomes.

Materials And Methods: Retrospective review of 168 patients, 146 with OPSCC and 22 with cervical SCC of unknown primary site (SCCUP). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104670DOI Listing

TORS Base-of-Tongue Mucosectomy in Human Papilloma Virus-Negative Carcinoma of Unknown Primary.

Laryngoscope 2020 Apr 2. Epub 2020 Apr 2.

Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, U.S.A.

Objective: To analyze the role of transoral robotic base-of-tongue mucosectomy in a cohort of patients with human papilloma virus negative unknown primary carcinoma.

Study Design: Retrospective database analysis.

Methods: A retrospective database review from 2012 to 2018 was performed at two large tertiary centers to study patients with human papilloma virus (HPV)-negative unknown primary carcinoma who underwent transoral robotic base-of-tongue mucosectomy. Read More

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http://dx.doi.org/10.1002/lary.28617DOI Listing

Failure patterns of cervical lymph nodes in metastases of unknown origin according to target volume.

Radiat Oncol J 2020 Mar 30;38(1):18-25. Epub 2020 Mar 30.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: This study was aim to evaluate the patterns of failure according to radiotherapy (RT) target volume for cervical lymph nodes in metastases of unknown primary origin in head and neck region (HNMUO).

Materials And Methods: Sixty-two patients with HNMUO between 1998 and 2016 were retrospectively reviewed. We analyzed the clinical outcomes and primary site failure depending on the radiation target volume. Read More

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http://dx.doi.org/10.3857/roj.2020.00108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113154PMC

Multiple Primary Malignant Neoplasms: An Unusual Case of Metachronous Breast Ductal and Squamous Cell Carcinomas.

Cureus 2020 Feb 11;12(2):e6954. Epub 2020 Feb 11.

Internal Medicine, Howard University Hospital, Washington, D.C., USA.

Multiple primary malignant neoplasms (MPMN) are generally defined as the co-occurrence of multiple primary malignant neoplasms of distinct histology in the same individual. Second and higher-order primary malignancies now comprise about 18% of all incidence of cancer in the USA. The incidence ratio of developing multiple primary cancers (MPCs) in female cancer survivors is 1. Read More

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http://dx.doi.org/10.7759/cureus.6954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067516PMC
February 2020

Incidence of Micrometastasis and Isolated Tumour Cells in Clinicopathologically Node-Negative Head and Neck Squamous Cell Carcinoma.

J Maxillofac Oral Surg 2020 Mar 15;19(1):131-135. Epub 2019 May 15.

2Department of Head and Neck Surgical Oncology, HCG Cancer Centre, Bengaluru, India.

Introduction: Occult neck node metastasis in head and neck squamous cell carcinoma (HNSCC) in the form of micrometastasis and isolated tumour cell (ITC) often goes unnoticed in the routine pathological examination. This limitation can be overcome by using serial sectioning and immunohistochemistry for detection of micrometastasis and ITC in clinically and pathologically node-negative neck. The primary objective was to determine the incidence of micrometastasis and ITC in the selective neck dissection specimen, whereas to determine the levels of lymph nodes involved, depending upon the site of primary tumour, was the secondary objective. Read More

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http://dx.doi.org/10.1007/s12663-019-01239-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954931PMC

Finding/identifying primaries with neck disease (FIND) clinical trial protocol: a study integrating transoral robotic surgery, histopathological localisation and tailored deintensification of radiotherapy for unknown primary and small oropharyngeal head and neck squamous cell carcinoma.

BMJ Open 2019 Dec 30;9(12):e035431. Epub 2019 Dec 30.

Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Introduction: Carcinomas of unknown primary site (CUP) of the head and neck have historically been worked up and managed heterogeneously. Failure to identify a primary site may result in large radiotherapy mucosal volumes. Transoral approaches such as Transoral Robotic Surgery (TORS) may improve the yield of identifying hidden primaries. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955504PMC
December 2019

Signet-ring cell adenocarcinoma of unknown primary presenting with superior vena cava (SVC) syndrome: rare type of cancer.

BMJ Case Rep 2019 Dec 29;12(12). Epub 2019 Dec 29.

Department of Laboratories, College of Medicine & Philippine General Hospital, University of the Philippines Manila, Manila, Metro Manila, Philippines.

A 53-year-old man presented with a 3-month history of progressive, non-productive cough followed by occasional swelling of the face and upper extremities. Physical examination on admission revealed prominent superficial vessels at the neck and upper extremity swelling. Bronchoscopy revealed the superior segment of the right lower lobe was narrow but without visible mass; cell block and biopsy done revealed signet-ring cell carcinoma with an immunohistochemistry pattern favouring the primary site of malignancy as either gastric or of the pancreaticobiliary tree. Read More

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http://dx.doi.org/10.1136/bcr-2019-232269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936546PMC
December 2019

High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma.

J Cancer 2019 17;10(27):6910-6914. Epub 2019 Nov 17.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. Read More

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http://dx.doi.org/10.7150/jca.37515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909940PMC
November 2019

Occult Primary with Cervical Secondary-Role of CT Scan and Evaluation Under Anesthesia.

Indian J Otolaryngol Head Neck Surg 2019 Oct 20;71(Suppl 1):157-161. Epub 2017 Jul 20.

31, Sangana Society, Near Navyug College, Rander Road, Surat, 395009 India.

The potential of CT, MRI or both to detect a primary tumor ranges from 9.3 to 23% rising to 60% when suspicious radiological findings direct subsequent endoscopic biopsies (Zhuang et al. in Mol Clin Oncol 2:917-922, 2014). Read More

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http://dx.doi.org/10.1007/s12070-017-1166-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848291PMC
October 2019

Cancer of Unknown Primary: A Review on Clinical Guidelines in the Development and Targeted Management of Patients with the Unknown Primary Site.

Cureus 2019 Sep 2;11(9):e5552. Epub 2019 Sep 2.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Cancer of unknown primary (CUP) is a malignant widespread metastatic disease without an identifiable primary site after extensive clinical investigation. Recently, a decline is observed in the diagnosis of CUP, mainly due to improvement in detection of the primary tumors, thus decreasing the unknown primaries. Worldwide, CUP is the sixth to eighth most common malignancy, accounting for 2. Read More

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http://dx.doi.org/10.7759/cureus.5552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820325PMC
September 2019
1 Read

Illustration of a fatal radiation-induced lung aneurysm: Is central lung stereotactic radiotherapy to be banned?

Cancer Radiother 2019 Dec 11;23(8):926-929. Epub 2019 Oct 11.

Namur Research Institute in Life Sciences (Narilis), Namur, Belgium; Department of Radiation Oncology, CHU UCL Namur, site Sainte-Élisabeth, place Louise-Godin 15, 5000 Namur, Belgium.

Stereotactic body radiation therapy is still controversial for inoperable patients with central lung lesion. We report the case of a 59-year-old woman with previous history of head and neck squamous cell carcinoma who was treated by lung stereotactic body irradiation for an inoperable lymph node in station 10R. One year after, a fibroscopy showed a necrosis of the right main bronchus mucosae and the CT showed a radio-induced aneurysm protruding into the right inferior lobular bronchus. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.05.016DOI Listing
December 2019

The impact of the patient's condition, diagnostic procedures and treatment on the survival of carcinoma of unknown primary site patients.

Cancer Manag Res 2019 16;11:6603-6614. Epub 2019 Jul 16.

Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Wrocław, Poland.

Introduction: Carcinoma of unknown primary site (CUP) refers to 1-5% of all head and neck neoplasms. Very often, the primary site remains difficult to determine. Squamous cell carcinoma is the most frequent histopathological type diagnosed in the head and neck region. Read More

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http://dx.doi.org/10.2147/CMAR.S204346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642654PMC
July 2019
3 Reads

Hypoglycemia associated with disseminated metastatic tonsillar squamous cell carcinoma producing insulin-like growth factor-I in a Pomeranian dog.

Vet Clin Pathol 2019 Sep 6;48(3):429-434. Epub 2019 Jul 6.

Synergy Animal General Hospital, Kawaguchi-shi, Saitama, Japan.

A 13-year-old spayed female Pomeranian dog was presented for persistent, severe hypoglycemia (37 mg/dL; reference interval [RI] 75-128 mg/dL). Progressive nonregenerative anemia (hematocrit 23.3%-15. Read More

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http://dx.doi.org/10.1111/vcp.12753DOI Listing
September 2019
2 Reads

Image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site.

Cancer Radiother 2019 Sep 27;23(5):426-431. Epub 2019 Jun 27.

Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China. Electronic address:

The purpose of this article was to report the treatment effect of image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site. The patient was a 75-year-old male. A diagnostic biopsy showed metastatic squamous cell carcinoma and the tumour size was 7. Read More

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http://dx.doi.org/10.1016/j.canrad.2019.01.006DOI Listing
September 2019
2 Reads

Eliminating Postoperative Radiation to the Pathologically Node-Negative Neck: Long-Term Results of a Prospective Phase II Study.

J Clin Oncol 2019 10 27;37(28):2548-2555. Epub 2019 Jun 27.

Washington University, St Louis, MO.

Purpose: The volume treated with postoperative radiation therapy (PORT) is a mediator of toxicity, and reduced volumes result in improved quality of life (QOL). In this phase II trial, treatment volumes were reduced by omitting PORT to the pathologically negative (PN0) neck in patients with primary head and neck squamous cell carcinoma.

Methods: Patients with head and neck squamous cell carcinoma who underwent surgical resection and neck dissection with a PN0 neck and high-risk features mandating PORT to the primary and/or involved neck were eligible. Read More

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http://dx.doi.org/10.1200/JCO.19.00186DOI Listing
October 2019
10 Reads

Examining tumor modulating effects of photobiomodulation therapy on head and neck squamous cell carcinomas.

Photochem Photobiol Sci 2019 Jul;18(7):1621-1637

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba-SP, Brazil. and Department of Oral Pathology, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre-RS, Brazil.

Photobiomodulation (PBM) therapy is an effective method for preventing and managing oral mucositis (OM) in head and neck squamous cell carcinoma (HNSCC) patients undergoing radiotherapy alone or in combination with chemotherapy. However, the potential effects of PBM therapy on premalignant and malignant cells eventually present in the treatment site are yet unknown. The aim of this systematic review was to analyze the effects of PBM therapy on HNSCC. Read More

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http://dx.doi.org/10.1039/c9pp00120dDOI Listing
July 2019
7 Reads

Differentiation of lymphomatous, metastatic, and non-malignant lymphadenopathy in the neck with quantitative diffusion-weighted imaging: systematic review and meta-analysis.

Neuroradiology 2019 Aug 7;61(8):897-910. Epub 2019 Jun 7.

Department of Radiology and Biomedical Imaging, Yale School of Medicine, Box 208042, 333 Cedar St, Tompkins East 2, New Haven, CT, 06520-8042, USA.

Purpose: To perform a systematic review and meta-analysis of literature comparing average apparent diffusion coefficient (ADC) for differentiating lymphomatous, metastatic, and non-malignant cervical lymphadenopathy.

Methods: We performed a comprehensive literature search of Ovid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection. Studies comparing average ADC of lymphomatous, metastatic, and non-malignant neck lymph nodes were included. Read More

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http://dx.doi.org/10.1007/s00234-019-02236-7DOI Listing
August 2019
9 Reads

Heterogeneity in the clinical presentation, diagnosis, and treatment initiation of p16-positive oropharyngeal cancer.

Am J Otolaryngol 2019 Sep - Oct;40(5):626-630. Epub 2019 May 14.

Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, 1611 W Harrison St, Chicago, IL 60612, USA. Electronic address:

Background: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) has a patient demographic, presentation, and clinical treatment response distinct from HPV-unassociated OPSCC. The heterogeneity in presentation and diagnosis within a patient population with HPV-positive OPSCC and its impact on times to presentation, diagnosis, and treatment have yet to be characterized.

Participants: Patients with biopsy-proven p16-positive OPSCC seen and/or treated at our institution between 2008 and 2018. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.05.004DOI Listing
February 2020
6 Reads

Small Cell Carcinoma in the Head and Neck.

Ann Otol Rhinol Laryngol 2019 Nov 4;128(11):1006-1012. Epub 2019 Jun 4.

Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objectives: Small cell carcinomas in extrapulmonary sites (ESmCCs) are very rare. ESmCCs originating in the head and neck account for approximately 10% of all ESmCCs, and there are few reports about this disease. ESmCCs have an aggressive natural history characterized by widespread metastasis. Read More

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http://dx.doi.org/10.1177/0003489419853601DOI Listing
November 2019
24 Reads

Isolated pancreatic metastasis from malignant melanoma: a case report and literature review.

Clin J Gastroenterol 2019 Dec 27;12(6):626-636. Epub 2019 May 27.

Department of Endoscopy, Mie University Hospital, Tsu, Mie, Japan.

Isolated pancreatic metastasis from malignant melanoma is rare. Pancreatic metastasis is difficult to diagnose in patients with unknown primary malignant melanoma. Endoscopic ultrasound-guided fine-needle aspiration plays an important role in confirming the diagnosis. Read More

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http://dx.doi.org/10.1007/s12328-019-00996-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885028PMC
December 2019
7 Reads

The emerging role of trans-oral robotic surgery for the detection of the primary tumour site in patients with head-neck unknown primary cancers: A meta-analysis.

Auris Nasus Larynx 2019 Oct 4;46(5):663-671. Epub 2019 May 4.

Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy.

The identification of the site in head neck unknown primary (HNUP) tumour is of utmost importance to help select best treatment while decreasing treatment-related morbidity and mortality. The primary purpose of this study is to demonstrate that TORS may be a valuable tool in detecting primary tumour. Studies were systematically searched in the PubMed, EMBASE, the Cochrane Library and CENTRAL electronic databases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03858146193011
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http://dx.doi.org/10.1016/j.anl.2019.04.007DOI Listing
October 2019
14 Reads

FDG PET/CT for metastatic squamous cell carcinoma of unknown primary of the head and neck.

Authors:
Yiyan Liu

Oral Oncol 2019 05 19;92:46-51. Epub 2019 Mar 19.

Nuclear Medicine Service, Department of Radiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA. Electronic address:

Objective: The role of FDG PET/CT is uncertain in squamous cell carcinoma of unknown primary (SCCUP). Published data are limited by heterogeneity of pathology, varied diagnostic criteria, and small sample size.

Materials/methods: This retrospective study was conducted in 40 patients who had FDG PET/CT for SCCUP. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.03.014DOI Listing
May 2019
1 Read

Head and neck carcinoma of unknown primary.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Jun 17;136(3):185-192. Epub 2019 Apr 17.

Département d'orl et chirurgie cervico faciale, hôpital universitaire Gui de Chauliac, université de Montpellier, CHRU de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.

In adult cervicofacial pathology, carcinoma of unknown primary is defined as lymph-node metastasis the anatomic origin of which is not known at the time of initial management. It constitutes up to 5% of head and neck cancers. Presentation may suggest benign pathology, delaying and confusing oncologic treatment. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.002DOI Listing
June 2019
3 Reads

A specific sequence in the genome of respiratory syncytial virus regulates the generation of copy-back defective viral genomes.

PLoS Pathog 2019 04 17;15(4):e1007707. Epub 2019 Apr 17.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Defective viral genomes of the copy-back type (cbDVGs) are the primary initiators of the antiviral immune response during infection with respiratory syncytial virus (RSV) both in vitro and in vivo. However, the mechanism governing cbDVG generation remains unknown, thereby limiting our ability to manipulate cbDVG content in order to modulate the host response to infection. Here we report a specific genomic signal that mediates the generation of a subset of RSV cbDVG species. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504078PMC
April 2019
2 Reads

Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: Systematic review and meta-analysis.

Oral Oncol 2019 04 6;91:97-106. Epub 2019 Mar 6.

Department of Otolaryngology, Head and Neck Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Head and Neck Studies and Education, University of Birmingham, UK; Institute of Cancer and Genomic Sciences, University of Birmingham, UK. Electronic address:

Background: The use of transoral robotic surgery (TORS) and laser microsurgery (TLM) in the diagnosis and identification of the site of the unknown primary has become increasingly common. This systematic review and meta-analysis aims to assess the use and efficacy of TORS and TLM for this indication.

Method: Systematic review and meta-analysis of studies employing TORS or TLM in diagnosis of the unknown primary tumor site in patients with cervical nodal metastases of squamous cell origin. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.018DOI Listing
April 2019
29 Reads

Patterns of EBV-positive cervical lymph node involvement in head and neck cancer and implications for the management of nasopharyngeal carcinoma T0 classification.

Oral Oncol 2019 04 16;91:7-12. Epub 2019 Feb 16.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China. Electronic address:

Objectives: Epstein-Barr virus (EBV)-positive cervical lymph node (CLN) metastasis of unknown primary origin is classified as nasopharyngeal carcinoma (NPC) T0 by the American Joint Committee on Cancer staging manual (8th edition). We aimed to investigate the possible primary sites and patterns of EBV-positive CLN metastases and to provide implications for the management of NPC T0 classification.

Materials And Methods: We retrospectively reviewed 269 patients with newly diagnosed EBV-positive CLN metastatic disease who underwent EBV detection via EBV-encoded RNA in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.012DOI Listing
April 2019
15 Reads

Neck management in head and neck squamous cell carcinomas: where do we stand?

Med Oncol 2019 Mar 27;36(5):40. Epub 2019 Mar 27.

Radiation Oncology Department, François Baclesse Center/ARCHADE, Normandy University, 3 Avenue du Général Harris, 14000, Caen, France.

Head and neck squamous-cell carcinomas (HNSCCs) have a significant lymph node tropism. This varies considerably depending on the primary tumor site and the Human Papillomavirus (HPV) status of the disease. The best therapeutic option, between up-front lymph node dissection and chemoradiotherapy (CRT) +/- followed by lymph node dissection in case of persistent lymphadenopathy or regional relapse, remains unclear. Read More

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http://dx.doi.org/10.1007/s12032-019-1265-1DOI Listing
March 2019
10 Reads

Prostate Cancer Metastasis To Cervical Node Chain-An Unusual Clinic-Pathological Finding.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):134-135

Department of Surgery, Aga Khan University Hospital, Karachi, Pakistan.

Prostate carcinoma is one of the most common cancers in males all around the world. Head and neck squamous cell carcinoma is amongst the leading carcinoma (HNSCC) in men especially in the sub-continent. There are around 150 lymph nodes on either side in the neck and cervical lymph nodes are a common site for head and neck malignancies to metastasize however carcinoma of prostate may in rare cases metastasize to cervical chain, therefore warranting a neck dissection. Read More

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May 2019
8 Reads

Real-time PCR HPV genotyping in fine needle aspirations of metastatic head and neck squamous cell carcinoma: Exposing the limitations of conventional p16 immunostaining.

Oral Oncol 2019 03 7;90:74-79. Epub 2019 Feb 7.

Department of Pathology, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, United States. Electronic address:

Background: Given the propensity for HPV-positive head and neck squamous cell carcinoma (HPV-HNSCC) to metastasize to cervical lymph nodes, fine needle aspiration (FNA) plays an important diagnostic role in their initial detection. Indeed, there is now an unwavering commitment to HPV testing of FNAs even in the absence of clear methodologic guidelines and threshold criteria. A particular difficulty pertains to the interpretation of p16 staining. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.02.006DOI Listing
March 2019
2 Reads

Unknown primary of the head and neck: a new entry in the TNM staging system with old dilemmas for everyday practice.

Curr Opin Otolaryngol Head Neck Surg 2019 Apr;27(2):73-79

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS National Cancer Institute of Milan.

Purpose Of Review: To summarize the most recent nuances in diagnosis, management, and prognostic stratification of carcinoma of unknown primary of the head and neck (CUPHN), in light of its recent re-assessment in the eighth edition of the TNM Classification Manual.

Recent Findings: At least in Western Countries, most CUPHN are expected to be Human Papilloma Virus (HPV)-positive with an oropharyngeal origin. Their appropriate diagnosis starts with fine needle aspiration cytology and/or core biopsy of pathologic lymph node(s) with staining for p16 by immunohistochemistry and subsequent HPV detection by PCR. Read More

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http://dx.doi.org/10.1097/MOO.0000000000000528DOI Listing
April 2019
11 Reads

Morbidity and mortality among patients with head and neck cancer in the emergency department: A national perspective.

Head Neck 2019 04 24;41(4):1007-1015. Epub 2019 Jan 24.

Center for Global Surgery Evaluation, Massachusetts Eye and Ear, Boston, Massachusetts.

Background: Emergency departments are playing an increasing role in cancer management. Emergency department utilization by patients with head and neck cancer, however, is unknown.

Methods: The 2009-2011 Nationwide Emergency Department Sample was queried for patients with a principle diagnosis of head and neck cancer. Read More

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http://dx.doi.org/10.1002/hed.25534DOI Listing
April 2019
15 Reads

Ultraviolet light-related DNA damage mutation signature distinguishes cutaneous from mucosal or other origin for head and neck squamous cell carcinoma of unknown primary site.

Head Neck 2019 06 11;41(6):E82-E85. Epub 2019 Jan 11.

Department of Anatomic Pathology, University of California San Francisco, San Francisco, California.

Background: Head and neck squamous cell carcinoma of unknown primary site (HNSCCUP) is a diagnostic challenge. Identification of an ultraviolet (UV) light-related DNA damage signature using next-generation sequencing (NGS) can classify the primary site of origin as cutaneous.

Methods: A 62-year-old male was seen with 2 months of left neck swelling. Read More

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http://dx.doi.org/10.1002/hed.25613DOI Listing
June 2019
19 Reads

Evidence for the approach to the diagnostic evaluation of squamous cell carcinoma occult primary tumors of the head and neck.

Oral Oncol 2019 01 30;88:145-152. Epub 2018 Nov 30.

Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address:

Metastases to the cervical lymph nodes from a occult primary (CUP) of head and neck squamous carcinomas has been increasing in presentation (HNSCC). Modern diagnostic workup, including clinical evaluation, conventional imaging, FDG-PET/CT and panendoscopy/tonsillectomy enables detection of the primary site in over half of all cases, and is associated with significantly improved survival rates. Recent studies have demonstrated the utility of novel molecular pathology and transoral surgical techniques in improving diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.11.020DOI Listing
January 2019
12 Reads

The Impact of a Stepwise Approach to Primary Tumor Detection in Squamous Cell Carcinoma of the Neck With Unknown Primary.

Laryngoscope 2019 07 22;129(7):1610-1616. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Baltimore, Maryland, U.S.A.

Objectives/hypothesis: To examine the cumulative effect of diagnostic steps for primary tumor identification in patients with head and neck squamous cell carcinoma of unknown primary (HNSCCUP), including lingual tonsillectomy, and the impact of primary tumor identification on subsequent treatment.

Study Design: Retrospective analysis.

Methods: We reviewed the records of 110 patients diagnosed with HNSCCUP between 2003 and 2015. Read More

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http://doi.wiley.com/10.1002/lary.27625
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http://dx.doi.org/10.1002/lary.27625DOI Listing
July 2019
33 Reads

Treatment outcomes of squamous cell carcinoma of the oral cavity in young adults.

Oral Oncol 2018 12 22;87:43-48. Epub 2018 Oct 22.

Department of Radiation Oncology, Mayo Clinic Hospital, Phoenix, AZ, United States. Electronic address:

Objectives: The natural history of squamous cell carcinoma (SCC) of the oral cavity (OC) in young adults is unknown. We sought to provide an updated report on treatment outcomes of patients with OC SCC who were 40 years or younger.

Materials And Methods: We performed a retrospective analysis of 124 consecutive patients with primary OC SCC treated at Mayo Clinic (1980-2014). Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.10.014DOI Listing
December 2018
6 Reads

HPV-associated neuroendocrine carcinomas of the head and neck in FNA biopsies: Clinicopathologic features of a rare entity.

Cancer Cytopathol 2019 02 26;127(1):26-34. Epub 2018 Nov 26.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Background: The majority of human papillomavirus (HPV)-associated oropharyngeal carcinomas are squamous cell carcinomas; however, there are rare reports of HPV-associated neuroendocrine carcinomas (HPV-NECs) in the upper aerodigestive tract. The aim of this study was to characterize the diagnostic features of fine-needle aspiration (FNA) cases of head and neck HPV-NEC.

Methods: Cytology cases of HPV-NEC were identified over a 3-year period from 2 institutions. Read More

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http://dx.doi.org/10.1002/cncy.22075DOI Listing
February 2019
7 Reads

Tongue base mucosectomy for carcinoma of unknown primary using endoscopic electrocautery: rationale for wider implementation of an institutionally restricted technique.

J Laryngol Otol 2018 Dec 20;132(12):1138-1142. Epub 2018 Nov 20.

Department of ENT, Head and Neck Surgery,Royal Sussex County Hospital,Brighton, and Head and Neck Unit,Queen Victoria Hospital,East Grinstead,UK.

Background: Cervical metastasis from an unknown primary site invariably results in pan-mucosal irradiation if a primary tumour is not identified. Transoral robotic and laser-assisted mucosectomy are valid techniques to increase diagnostic rates, but these remain restricted to certain centres. This paper describes, in detail, a technique in which mucosectomy is performed via endoscopic electrocautery. Read More

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http://dx.doi.org/10.1017/S0022215118002062DOI Listing
December 2018
69 Reads

Palatine tonsil SUVmax on FDG PET-CT as a discriminator between benign and malignant tonsils in patients with and without head and neck squamous cell carcinoma of unknown primary.

Clin Radiol 2019 02 16;74(2):165.e17-165.e23. Epub 2018 Nov 16.

King's College London and St Guy's and St Thomas' PET Centre, London, UK.

Aim: To analyse the maximum standardised uptake value (SUVmax) ratio between tonsils in patients with and without tonsillar carcinoma to determine useful diagnostic thresholds.

Materials And Methods: Positron-emission tomography (PET)/computed tomography (CT) examinations of patients with suspected head and neck squamous cell carcinoma (SCC) and controls from April 2013 to September 2016 were reviewed retrospectively. Tonsillar SUVmax ratios (ipsilateral/contralateral for malignant tonsils, maximum/minimum for patients without [controls]) were calculated and used to construct a receiver operating characteristic (ROC) curve. Read More

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http://dx.doi.org/10.1016/j.crad.2018.10.007DOI Listing
February 2019
2 Reads

Endobronchial ultrasound-guided transbronchial needle aspiration cytology in patients with known or suspected extra-pulmonary malignancies: A cytopathology-based study.

Cytopathology 2019 01 21;30(1):82-90. Epub 2018 Dec 21.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is the primary modality for mediastinal lymph node staging in lung carcinoma. We aimed to evaluate its utility in extra-pulmonary malignancies (EPM).

Methods: Database search of EBUS-TBNA aspirations (2013-2017) done in patients with known/suspected EPMs and mediastinal lymphadenopathy/masses was performed. Read More

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http://dx.doi.org/10.1111/cyt.12656DOI Listing
January 2019
9 Reads
1.481 Impact Factor

ROS1-rearranged putative lung adenocarcinoma presenting as carcinoma of unknown primary site: a case report.

Oncotarget 2018 Oct 16;9(81):35278-35282. Epub 2018 Oct 16.

Department of Molecular and Internal Medicine, Institute of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.

Carcinoma of unknown primary site (CUP) is diagnosed only in 2-9% of all cancer cases. Adenocarcinomas account for approximately 60% of CUP, and some of these are putative lung adenocarcinomas. The frequency of driver oncogene positivity in the putative lung adenocarcinomas is unknown, and the efficacy of targeting therapies for the driver oncogene is also unknown. Read More

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http://www.oncotarget.com/fulltext/26233
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http://dx.doi.org/10.18632/oncotarget.26233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219662PMC
October 2018
22 Reads

Transoral Robotic Surgery and the Unknown Primary.

ORL J Otorhinolaryngol Relat Spec 2018;80(3-4):148-155. Epub 2018 Nov 12.

University of Pittsburgh, Department of Otolaryngology, Eye & Ear Institute, Veterans Affairs Pittsburgh Health System, Pittsburgh, Pennsylvania, USA.

Carcinoma of unknown primary (CUP) comprises approximately 1%-5% of all head and neck malignancies. Primary site detection rates for metastatic cervical squamous cell carcinoma (SCC) remain variable, with current diagnostic imaging unable to identify all tumours. Prevailing evidence suggests that most head and neck CUP are located in the oropharynx. Read More

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https://www.karger.com/Article/FullText/490596
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http://dx.doi.org/10.1159/000490596DOI Listing
October 2019
33 Reads

Incisional Seeding of Metastatic Squamous Cell Carcinoma Following Carotid Endarterectomy: An Unusual Case of an Unknown Primary Cancer Presenting as a Presumed Neck Abscess.

Oper Neurosurg (Hagerstown) 2019 08;17(2):202-207

Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, Ontario, Canada.

Background: Carotid endarterectomy (CEA) is a safe and effective procedure, with a low risk of complications when performed by experienced surgeons. Postoperative infections are particularly rare, reportedly affecting less than 1% of cases. Incisional metastases have not been described. Read More

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http://dx.doi.org/10.1093/ons/opy335DOI Listing
August 2019
12 Reads

Combination of panendoscopy and positron emission tomography/computed tomography increases detection of unknown primary head and neck carcinoma.

Laryngoscope 2018 11 8;128(11):2573-2575. Epub 2018 Sep 8.

Department of Facial Plastic and Reconstructive Surgery , Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, U.S.A.

Objectives/hypothesis: With positron emission tomography/computed tomography (PET/CT) now commonplace as a diagnostic tool, new questions have arisen regarding the utility and cost-effectiveness of panendoscopy. In this retrospective review of a large cohort of head and neck squamous cell carcinoma of unknown primary (HNSCC-UP), we describe the enduring utility of panendoscopy in the detection of the primary site of mucosal disease even when PET/CT is negative.

Study Design: Retrospective cohort study. Read More

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http://dx.doi.org/10.1002/lary.27268DOI Listing
November 2018
49 Reads

Causes for delay before specialist consultation in head and neck cancer.

Acta Oncol 2018 Dec 24;57(12):1677-1686. Epub 2018 Aug 24.

a Department of Otorhinolaryngology - Head and Neck Surgery , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

Background: Head and neck cancers are often diagnosed at a late stage, thus resulting in a generally poor prognosis. This is partly attributable to patients' hesitancy in seeking treatment. However, the length and causes of these patient delays remain relatively unknown. Read More

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http://dx.doi.org/10.1080/0284186X.2018.1497297DOI Listing
December 2018
31 Reads

Treatment of Clinically Positive Cervical Lymph Nodes by Limited Local Node Excision and Adjuvant Radiotherapy in Melanoma Patients with Major Comorbidities.

Ann Surg Oncol 2018 Nov 16;25(12):3476-3482. Epub 2018 Aug 16.

Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.

Introduction: When cervical lymph nodes are clinically positive for metastatic melanoma, surgeons may be hesitant to recommend a therapeutic complete lymph node dissection if the patient is elderly or has major comorbidities. A limited local node excision of the clinically positive nodes only, followed by adjuvant radiotherapy to the entire node field, may be an effective alternative in such patients.

Methods: All patients who had presented with a primary head and neck melanoma or an unknown primary site and had subsequently undergone limited local node excision and adjuvant radiotherapy for macroscopically involved cervical nodes between 1993 and 2010 at a tertiary referral center were selected for study. Read More

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http://link.springer.com/10.1245/s10434-018-6692-2
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http://dx.doi.org/10.1245/s10434-018-6692-2DOI Listing
November 2018
36 Reads

Clinical profile and treatment outcomes of metastatic neuroendocrine carcinoma: A single institution experience.

South Asian J Cancer 2018 Jul-Sep;7(3):207-209

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Background: Neuroendocrine carcinoma (NEC) is a rare tumor arising from the diffuse neuroendocrine system. Most of these present in the advanced stage and palliative chemotherapy remains the only option. The prognosis remains poor with the standard chemotherapy regimen of platinum and etoposide (EP) providing modest survival benefit. Read More

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http://dx.doi.org/10.4103/sajc.sajc_176_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069343PMC
August 2018
150 Reads

Post-treatment sequelae and management of primary laryngeal NK/T-cell lymphoma: A case report.

Am J Otolaryngol 2018 Nov - Dec;39(6):781-784. Epub 2018 Jul 25.

Cleveland Clinic, 9500 Euclid Ave, A-71, Cleveland, OH 44195, United States of America. Electronic address:

Outcome Objectives: METHODS: Case Report, April 2016.

Results: A 27-year-old female presented with a three-week history of flu-like symptoms including sore throat, myalgia and insidious nasal congestion. Her hospital course was complicated by pancytopenia, extensive GI bleed of unknown origin and fever. Read More

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http://dx.doi.org/10.1016/j.amjoto.2018.07.017DOI Listing
February 2019
13 Reads