614 results match your criteria Neck Cancer Unknown Primary Site


Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report.

Head Neck 2022 May 5. Epub 2022 May 5.

Department of Otolaryngology - Head & Neck Surgery, University of California, Davis, Davis, California, USA.

Background: This study evaluated whether fluorescence lifetime imaging (FLIm), coupled with standard diagnostic workups, could enhance primary lesion detection in patients with p16+ head and neck squamous cell carcinoma of the unknown primary (HNSCCUP).

Methods: FLIm was integrated into transoral robotic surgery to acquire optical data on six HNSCCUP patients' oropharyngeal tissues. An additional 55-patient FLIm dataset, comprising conventional primary tumors, trained a machine learning classifier; the output predicted the presence and location of HNSCCUP for the six patients. Read More

View Article and Full-Text PDF

Carcinoma of Unknown Primary (CUP) versus CUP Turned to Primary Carcinoma of the Head and Neck-An Analysis of Diagnostic Methods and the Impact of Primary Tumor on Clinical Outcome.

Diagnostics (Basel) 2022 Apr 3;12(4). Epub 2022 Apr 3.

Institute of Head and Neck Diseases, Evangelical Hospital, 1180 Vienna, Austria.

Background: The purpose of this study was to analyze the value of different diagnostic methods in detecting the primary site and the impact of primary tumors on the clinical outcome of carcinoma of unknown primary (CUP).

Methods: In this multicenter, retrospective study, 124 patients with true CUP (n = 94) and CUP turned to primary carcinoma (n = 30) were included. Patients with evidence of primary site during the clinical examination were excluded a priori. Read More

View Article and Full-Text PDF

Unusual presentation of HPV-positive squamous cell carcinoma of the nasolacrimal duct as carcinoma of unknown primary.

Am J Otolaryngol 2022 May-Jun;43(3):103457. Epub 2022 Apr 6.

Division of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; Center for Head and Neck Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Most human papillomavirus (HPV)-positive carcinomas of unknown primary (CUP) in the cervical lymph nodes are ultimately found to arise from the oropharynx, which has by far the highest prevalence of HPV-positivity among head and neck tumors. However, HPV is also detected in a subset of tumors from other sites. In this case report, we describe the first reported instance of a lacrimal sac carcinoma presenting as an HPV-positive CUP. Read More

View Article and Full-Text PDF

The Narrow Band Imaging as an essential complement to White Light Endoscopy in Recurrent Respiratory Papillomatosis diagnostics and follow-up process.

Otolaryngol Pol 2021 Oct;76(1):1-5

Department of Otolaryngology, Head and Neck Surgery, Poznan University of Medical Sciences, Poland.

The aim of the study is to discuss the role of NBI imaging in upper respiratory papillomatosis (RRP). In the available literature on the subject, as of 2009, there have been 117 publications on NBI imaging focusing on the diagnosis of the upper respiratory and digestive tract, especially the larynx. They discuss the following diagnostic and therapeutic problems: identifying an abnormal vascular pattern within the mucosa, differentiating benign and malignant lesions, assessing the nature of lesions under the leukoplakia plaque, pre-operative definition of laryngeal cancer margins, supporting laser procedures to obtain safe margins, postoperative monitoring after cancer treatment, detecting second simultaneous and metachronic neoplasms and primary tumors in the case of metastases from an unknown primary site. Read More

View Article and Full-Text PDF
October 2021

Intraosseous carcinoma of the anterior maxilla identified as the occult primary tumour of carcinoma of unknown primary.

Int J Oral Maxillofac Surg 2022 Mar 26. Epub 2022 Mar 26.

Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Chikusa-ku, Nagoya, Japan.

Carcinoma of unknown primary (CUP) is defined as lymph node metastasis without a detectable origin until after the initial treatment has been performed. The most common occult primary site in the head and neck, as revealed by a review of the published literature, is the oropharynx. An occult primary site in the oral region is extremely rare. Read More

View Article and Full-Text PDF

Comprehensive evaluation on cancer of unknown primary site and how we managed it: A case report.

Int J Surg Case Rep 2022 Apr 16;93:106954. Epub 2022 Mar 16.

Department of Radiology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia.

Introduction And Importance: Cancer of unknown primary site (CUP) is metastatic cancer without primary tumor found from comprehensive medical history, physical examination, and regular laboratory examination. Eighty percent of CUP include unfavorable groups with 3 to 6 months of median survival despite chemotherapy treatment.

Case Presentation: A 52-year-old male was presented with a chief complaint of a recurrent lump in the neck and axilla. Read More

View Article and Full-Text PDF

Oral metastasis as the first indication of undiscovered malignancy at a distant site: A systematic review of 413 cases.

Head Neck 2022 Jul 25;44(7):1715-1724. Epub 2022 Mar 25.

Department of Dentistry, State University of Maringá (UEM), Maringá, Brazil.

This systematic review is the first to provide evidence regarding demographic, clinical, and imaging characteristics, as well as information related to survival, of patients with oral and maxillofacial metastases of occult primary tumors. Case reports, case series, and cross-sectional studies were included. Ten databases were searched. Read More

View Article and Full-Text PDF

Clinicopathological and Molecular Features of Secondary Cancer (Metastasis) to the Thyroid and Advances in Management.

Int J Mol Sci 2022 Mar 17;23(6). Epub 2022 Mar 17.

Cancer Molecular Pathology, School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast 4222, Australia.

Secondary tumours to the thyroid gland are uncommon and often incidentally discovered on imaging. Symptomatic patients often present with a neck mass. Collision tumours of secondary tumours and primary thyroid neoplasms do occur. Read More

View Article and Full-Text PDF

Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy.

JCO Precis Oncol 2022 02;6:e2100383

Clinical Research Support Office, National Cancer Center Hospital East, Kashiwa, Japan.

Purpose: Circulating tumor DNA (ctDNA) genotyping may guide targeted therapy for patients with advanced GI cancers. However, no studies have validated ctDNA genotyping for microsatellite instability (MSI) assessment in comparison with a tissue-based standard.

Patients And Methods: The performance of plasma-based MSI assessment using Guardant360, a next-generation sequencing-based ctDNA assay, was compared with that of tissue-based MSI assessment using a validated polymerase chain reaction-based method in patients with advanced GI cancers enrolled in GOZILA study, a nationwide ctDNA profiling study. Read More

View Article and Full-Text PDF
February 2022

Recognizing Tumor Origin for Lymphoid Tumor of Unknown Primary Total-Body PET/CT Scan-Case Report.

Front Oncol 2022 3;12:766490. Epub 2022 Feb 3.

Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Localizing the site of tumor origin for patients with lymphoid tumor is fairly difficult before the definitive detection of the primary tumor, which causes redundant imaging examinations and medical costs. To circumvent this obstacle, the emergence of the world's first total-body positron emission tomography/computed tomography (PET/CT) provides a transformative platform for simultaneously static and dynamic human molecular imaging. Here, we reported a case of lymph node metastasis from an unknown primary tumor, and the primary tumor was detected with the aid of the total-body PET/CT scanner. Read More

View Article and Full-Text PDF
February 2022

Epidemiology and Molecular Profile of Mucosal Melanoma: A Population-Based Study in Southern Europe.

Cancers (Basel) 2022 Feb 3;14(3). Epub 2022 Feb 3.

Research Group on Descriptive Epidemiology, Genetics and Cancer Prevention, Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.

Background: Mucosal melanoma is a rare neoplasm on which few epidemiological population-based studies have been published. A good surgical approach is the standard treatment, but the prognosis is worse than that of skin melanoma. The analysis of mucosal melanoma's mutational profile can help to develop target therapies in advanced disease or adjuvant settings. Read More

View Article and Full-Text PDF
February 2022

[Clinicopathological Analysis of Brain Metastatic Carcinoma in Tibet].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Dec;43(6):869-874

Department of Pathology,Tibet Autonomous Region People's Hospital,Lhasa 850000,China.

Objective To investigate the clinicopathological features and immunohistochemical phenotypes of brain metastatic carcinoma in Tibetan patients. Methods The clinical and pathological data of all patients with brain metastases from 2014 to 2020 in Tibet Autonomous Region People's Hospital were retrospectively analyzed,including 13 cases of brain metastatic carcinoma.All cases were diagnosed and classified by immunohistochemical staining. Read More

View Article and Full-Text PDF
December 2021

Machine learning models predict the primary sites of head and neck squamous cell carcinoma metastases based on DNA methylation.

J Pathol 2022 04 20;256(4):378-387. Epub 2022 Jan 20.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Pathology, Berlin, Germany.

In head and neck squamous cell cancers (HNSCs) that present as metastases with an unknown primary (HNSC-CUPs), the identification of a primary tumor improves therapy options and increases patient survival. However, the currently available diagnostic methods are laborious and do not offer a sufficient detection rate. Predictive machine learning models based on DNA methylation profiles have recently emerged as a promising technique for tumor classification. Read More

View Article and Full-Text PDF

[Anti-nuclear matrix protein 2 antibody-positive dermatomyositis with the preferential involvement of neck extensors: a case report].

Rinsho Shinkeigaku 2021 Nov 16;61(11):743-749. Epub 2021 Oct 16.

Department of Neurology, Chugoku Rosai Hospital.

A 68-year-old man with a 2-month history of progressive weakness and spontaneous pain in proximal limb muscles presented to our hospital with a dropped head. He started experiencing progressive dysphagia several days before admission. On admission, he had muscle weakness of the limbs and neck extensors with edema and induration in distal extremities. Read More

View Article and Full-Text PDF
November 2021

Genomic Landscape of Angiosarcoma: A Targeted and Immunotherapy Biomarker Analysis.

Cancers (Basel) 2021 Sep 26;13(19). Epub 2021 Sep 26.

Department of Medicine, Hematology & Oncology, Sylvester Comprehensive Cancer Center, Jackson Memorial Hospital, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

We performed a retrospective analysis of angiosarcoma (AS) genomic biomarkers and their associations with the site of origin in a cohort of 143 cases. Primary sites were head and neck (31%), breast (22%), extremity (11%), viscera (20%), skin at other locations (8%), and unknown (9%). All cases had Next Generation Sequencing (NGS) data with a 592 gene panel, and 53 cases had Whole Exome Sequencing (WES) data, which we used to study the microenvironment phenotype. Read More

View Article and Full-Text PDF
September 2021

Relevance of perimarginal nodes for head and neck cancer.

Eur Arch Otorhinolaryngol 2022 May 27;279(5):2603-2609. Epub 2021 Aug 27.

Otorhinolaryngology and Head and Neck Surgery Clinic, Azienda Sanitaria Universitaria Giuliano Isontina-ASUGI, Strada di Fiume 447, 39149, Trieste, Italy.

Objective: To estimate the prevalence of metastasis in the perimarginal nodes (PMNs) (also known as perifacial, preglandular and retroglandual nodes) in head and neck cancer.

Methods: We recruited 136 patients affected by cancers of the oral cavity, lip, oropharynx, skin and by cáncer of unknown primary (CUP), who were candidates for level IB dissection. PMNs were identified and sent separately for histological analysis. Read More

View Article and Full-Text PDF

Current status of medical oncology in Japan and changes over the most recent 7-year period: results of a questionnaire sent to designated cancer care hospitals.

Jpn J Clin Oncol 2021 Nov;51(11):1622-1627

Department of Medical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Background: According to a questionnaire sent to Designated Cancer Care Hospitals in Japan in 2013, only 39.4% of the institutes had medical oncology departments. Furthermore, most of these medical oncology departments were primarily responsible for the treatment of limited disease categories and the administration of newly developed therapeutic modalities, including molecular-targeted therapy. Read More

View Article and Full-Text PDF
November 2021

Human Papillomavirus and Squamous Cell Carcinoma of Unknown Primary in the Head and Neck Region: A Comprehensive Review on Clinical Implications.

Viruses 2021 07 2;13(7). Epub 2021 Jul 2.

Department of Otorhinolaryngology, Head and Neck Surgery & Audiology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark.

Squamous cell carcinoma of unknown primary (SCCUP) is a challenging diagnostic subgroup of oropharyngeal squamous cell carcinoma (OPSCC). The incidence of SCCUP is increasing in parallel with the well-documented increase in OPSCC and is likewise driven by the increase in human papillomavirus (HPV). The SCCUP patient often presents with a cystic lymph node metastasis and undergoes an aggressive diagnostic and treatment program. Read More

View Article and Full-Text PDF

FAP imaging in rare cancer entities-first clinical experience in a broad spectrum of malignancies.

Eur J Nucl Med Mol Imaging 2022 01 3;49(2):721-731. Epub 2021 Aug 3.

National Center for Tumor Diseases (NCT), Heidelberg, Germany.

Purpose:  Ga-FAPI (fibroblast activation protein inhibitor) is a rapidly evolving and highly promising radiotracer for PET/CT imaging, presenting excellent results in a variety of tumor entities, particularly in epithelial carcinomas. This retrospective analysis sought to evaluate the potential and impact of FAPI-PET/CT in rare cancer diseases with respect to improvement in staging and therapy, based on tracer uptake in normal organs and tumors.

Material And Methods: Fifty-five patients with rare tumor entities, defined by a prevalence of 1 person out of 2000 or less, received a  Ga-FAPI-PET/CT scan. Read More

View Article and Full-Text PDF
January 2022

A Solitary Melanoma Metastasis Confined to the Submandibular Gland.

Case Rep Oncol 2021 May-Aug;14(2):957-962. Epub 2021 Jun 18.

Department of Otorhinolaryngology Head and Neck Surgery, AZ Jan Portaels, Vilvoorde, Belgium.

Malignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [. 2014;9(1):239-71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in females according to the American Cancer Society and the National Cancer Institute [. Read More

View Article and Full-Text PDF

Tumor primary site as a prognostic factor for Merkel cell carcinoma disease-specific death.

J Am Acad Dermatol 2021 11 29;85(5):1259-1266. Epub 2021 Jun 29.

Department of Dermatology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.

Background: Merkel cell carcinoma (MCC) primary site has not been fully investigated as a potential prognostic factor.

Objective: To determine the incidence by tumor primary site of death due to MCC.

Methods: We undertook a retrospective analysis of the Survival, Epidemiology, and End Results database. Read More

View Article and Full-Text PDF
November 2021

A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.

Mol Cell Proteomics 2021 27;20:100118. Epub 2021 Jun 27.

Laboratório Nacional de Biociências - LNBio, Centro Nacional de Pesquisa em Energia e Materiais - CNPEM, Campinas, SP, Brazil. Electronic address:

Oral squamous cell carcinoma (OSCC) has high mortality rates that are largely associated with lymph node metastasis. However, the molecular mechanisms that drive OSCC metastasis are unknown. Extracellular vesicles (EVs) are membrane-bound particles that play a role in intercellular communication and impact cancer development and progression. Read More

View Article and Full-Text PDF

Sparing the Larynx and Hypopharynx With Radiation Therapy for Squamous Cell Carcinoma of Unknown Primary Site and Predominant Adenopathy in Level IIA.

Pract Radiat Oncol 2021 Sep-Oct;11(5):366-373. Epub 2021 Jun 24.

Departments of Radiation Oncology. Electronic address:

Purpose: There is controversy about the need to target the mucosa of the larynx and hypopharynx during radiation therapy (RT) for squamous cell carcinoma of an unknown primary site (SCCA-UP). By 1997, the policy in our department was to target only the oropharynx and nasopharynx in patients with SCCA-UP metastatic to the level II cervical nodes. The purpose of this study was to report the rate of cancer recurrence in the larynx or hypopharynx using an approach that excluded these areas from the RT target volumes. Read More

View Article and Full-Text PDF
September 2021

Role of molecular signature to differentiate second primary lung cancer from metastasis in a patient with squamous cell carcinoma of oral cavity.

Cancer Rep (Hoboken) 2021 08 23;4(4):e1363. Epub 2021 Jun 23.

Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA.

Background: Lung is the most common site of distant metastasis for patients with head and neck squamous cell carcinoma (HNSCC). However, differentiating second primary lung cancers from metastasis may be difficult for p16 negative HNSCC.

Case: We describe a case of oral cavity squamous cell carcinoma (SCC) who was found to have lung nodule and hilar lymphadenopathy (LAD) after surgery and radiation therapy. Read More

View Article and Full-Text PDF

Cytokeratin 7 and 19 expression in oropharyngeal and oral squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2022 Mar 27;279(3):1435-1443. Epub 2021 May 27.

Department of Otolaryngology, South Infirmary Victoria University Hospital, Cork, T12 X23H, Ireland.

Purpose: The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium.

Methods: This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center. Read More

View Article and Full-Text PDF

Standardized Diagnostics Including PET-CT Imaging, Bilateral Tonsillectomy and Neck Dissection Followed by Risk-Adapted Post-Operative Treatment Favoring Radio-Chemotherapy Improve Survival of Neck Squamous Cell Carcinoma of Unknown Primary Patients.

Front Oncol 2021 7;11:682088. Epub 2021 May 7.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Leipzig, Germany.

Background: About five to 10% of cancers in the head and neck region are neck squamous cell carcinoma of unknown primary (NSCCUP). Their diagnosis and treatment are challenging given the risk of missing occult tumors and potential relapse. Recently, we described human papillomavirus (HPV)-related NSCCUP-patients (NSCCUP-P) as a subgroup with superior survival. Read More

View Article and Full-Text PDF

Cancer incidence and cancer death in relation to tobacco smoking in a population-based Australian cohort study.

Int J Cancer 2021 09 31;149(5):1076-1088. Epub 2021 May 31.

The Daffodil Centre, The University of Sydney, A Joint Venture With Cancer Council NSW, Sydney, Australia.

Tobacco smoke is a known carcinogen, but the magnitude of smoking-related cancer risk depends on country-specific, generational smoking patterns. We quantified cancer risk in relation to smoking in a population-based cohort, the 45 and Up Study (2006-2009) in New South Wales, Australia. Cox proportional hazards regressions estimated adjusted hazard ratios (HR) by self-reported smoking history at baseline (2006-2009) for incident, primary cancers via linkage to cancer registry data to 2013 and cancer death data to 2015. Read More

View Article and Full-Text PDF
September 2021

The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.

Transl Oncol 2021 Jul 28;14(7):101106. Epub 2021 Apr 28.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, China.

Background: Recent studies have reported that diffuse large B-cell lymphoma (DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. However, the risk of secondary malignant neoplasms (SMNs) in DLBCL survivors with different primary extranodal sites are unknown.

Methods: A total of 40,714 patients diagnosed with stage I/II DLBCL were included from the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2015. Read More

View Article and Full-Text PDF

Diagnostic approaches to carcinoma of unknown primary of the head and neck.

Eur J Cancer Care (Engl) 2021 Nov 1;30(6):e13459. Epub 2021 May 1.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Squamous cell carcinoma in cervical lymph nodes arising from an undetected primary tumour, termed carcinoma of unknown primary (SCCUP), is a well-recognized clinical presentation within head and neck oncology. SCCUP is a common presentation for patients with human papillomavirus-mediated oropharyngeal cancer (HPV + OPSCC), as patients with HPV + OPSCC often present with smaller primary tumours and early nodal metastasis. Meticulous work-up of the SCCUP patient is central to the management of these patients as identification of the primary site improves overall survival and allows for definitive oncologic resection or more focused radiation when indicated. Read More

View Article and Full-Text PDF
November 2021

NSD3-NUTM1-rearranged carcinoma of the median neck/thyroid bed developing after recent thyroidectomy for sclerosing mucoepidermoid carcinoma with eosinophilia: report of an extraordinary case.

Virchows Arch 2021 Dec 23;479(6):1095-1099. Epub 2021 Apr 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is an exceedingly rare low-grade thyroid malignancy of unknown histogenesis. NUT carcinoma is another rare, highly aggressive neoplasm with predilection for the midline, defined by recurrent NUTM1 fusions. The bromodomain family genes (BRD4 or BRD3) and rarely NSD3, ZNF532, or others are known fusion partners. Read More

View Article and Full-Text PDF
December 2021