31 results match your criteria Naunyn-Schmiedeberg's Archives of Pharmacology[Journal]

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Easy-to-use strategy for reference gene selection in quantitative real-time PCR experiments.

Naunyn Schmiedebergs Arch Pharmacol 2016 Dec 20;389(12):1353-1366. Epub 2016 Sep 20.

Klinik für Anästhesiologie & Intensivmedizin, Universität Duisburg-Essen and Universitätsklinikum Essen, Hufelandstr. 55, D-45122, Essen, Germany.

Real-time PCR is an indispensable technique for mRNA expression analysis but conclusions depend on appropriate reference gene selection. However, while reference gene selection has been a topic of publications, this issue is often disregarded when measuring target mRNA expression. Therefore, we (1) evaluated the frequency of appropriate reference gene selection, (2) suggest an easy-to-use tool for least variability reference gene selection, (3) demonstrate application of this tool, and (4) show effects on target gene expression profiles. Read More

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December 2016
4 Reads

Naunyn-Schmiedeberg's Archives of Pharmacology under new editorship: change and continuity.

Roland Seifert

Naunyn Schmiedebergs Arch Pharmacol 2016 Jul 24;389(7):667-70. Epub 2016 May 24.

Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

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July 2016
2 Reads

Are blood vessels a target to treat lower urinary tract dysfunction?

Naunyn Schmiedebergs Arch Pharmacol 2015 Jul 31;388(7):687-94. Epub 2015 May 31.

Department of Pharmacology, Johannes Gutenberg Universität, Obere Zahlbacher Str. 67, 55101, Mainz, Germany,

Bladder dysfunction is common in the general population (Stewart et al. 2010) and even more so among patients seeing a physician for any reason (Goepel et al. 2002). Read More

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July 2015
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Publication trends in Naunyn-Schmiedeberg's Archives of Pharmacology: focus on pharmacology in Egypt.

Naunyn Schmiedebergs Arch Pharmacol 2013 Nov 14;386(11):929-33. Epub 2013 Sep 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

In a previous analysis of the country of origin of papers published in Naunyn-Schmiedeberg's Archives of Pharmacology, a major shift toward contributions from emerging market countries, was noticed in comparison of 2010 to 2001 publications. Repeating such analysis for 2012 publications in the journal confirmed this trend. An interesting new trend was the emerging presence of papers from a variety of Islamic countries including Egypt. Read More

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November 2013
2 Reads

The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2013 Jun 4;386(6):479-91. Epub 2013 Apr 4.

Department of Molecular and Cellular Biology, Theravance, Inc., 901 Gateway Boulevard, South San Francisco, CA 94080, USA.

The clinical efficacy of opioid receptor antagonists for the treatment of opioid-induced constipation (OIC) is established. Peripherally selective antagonists are intended to provide OIC symptom relief without compromising the analgesic effects of centrally penetrant opioid agonists. We describe the in vitro profile of a novel opioid receptor antagonist, TD-1211, at recombinant (human μ and δ, and guinea pig κ) and rodent native opioid receptors. Read More

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June 2013
1 Read

An anthology from Naunyn-Schmiedeberg's archives of pharmacology.

Naunyn Schmiedebergs Arch Pharmacol 2007 Apr 20;375(2):81-4. Epub 2007 Feb 20.

Science and Medical Affairs, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Bldg. H821, 65926, Frankurt am Main, Germany.

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April 2007
12 Reads

An anthology from Naunyn-Schmiedeberg's Archives of Pharmacology.

Martin C Michel

Naunyn Schmiedebergs Arch Pharmacol 2006 May;373(2):139

Department of Pharmacology and Pharmacotherapy, Academic Medical Center, Unversity of Amsterdam, Amsterdam, The Netherlands.

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Nandrolone treatment decreases the alpha1B-adrenoceptor mRNA level in rat kidney, but not the density of alpha1B-adrenoceptors in cultured MDCK-D1 kidney cells.

Eur J Pharmacol 2005 Dec 23;527(1-3):157-62. Epub 2005 Nov 23.

Department of Neuroscience, Division of Pharmacology, Uppsala University, Uppsala, Sweden.

We have previously shown that treatment of rats with the anabolic androgen steroid nandrolone decreased the density of alpha1B-adrenoceptors in the rat kidney [Uhlén, S., Lindblom, J., Kindlundh, A. Read More

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December 2005
2 Reads

Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist.

Eur J Med Chem 2004 Apr;39(4):345-57

Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

NF449 [4,4',4",4"'-(carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid-octasodiumsalt)] was recently described to inhibit recombinant rP2X(1) receptors (Naunyn Schmiedeberg's Arch. Pharmacol. 364 (2001) 285). Read More

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April 2004
6 Reads

Evaluation of reactive blue 2 derivatives as selective antagonists for P2Y receptors.

Vascul Pharmacol 2002 Dec;39(6):309-15

Biomedical Sciences Division, School of Applied Sciences, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1SB, UK.

P2Y receptor pharmacology is hampered by a lack of subtype selective antagonists. However, a recent study evaluated series of compounds, structurally related to the dye reactive blue 2, for their antagonist selectivity at P2X vs. P2Y receptors. Read More

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December 2002

Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.

Pharmacopsychiatry 2003 Jun;36 Suppl 1:S78-83

Department of Pharmacology, Johannes Gutenberg University of Mainz, Mainz, Germany.

We have previously shown that hypoxia and N-methyl-D-aspartate (NMDA) receptor activation induce breakdown of choline-containing phospholipids in rat hippocampus, a process which is mediated by calcium influx and phospholipase A (2) activation. Bilobalide, a constituent of Ginkgo biloba, inhibited this process in a potent manner (Weichel et al., Naunyn-Schmiedeberg's Arch. Read More

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Inhibition of 5-HT3 receptors by propofol: equilibrium and kinetic measurements.

Neuropharmacology 2000 Apr;39(6):1064-74

Klinik für Anästhesiologie und spezielle Intensivmedizin, Universitätskliniken Bonn, Sigmund-Freud Strasse 25, D-53105, Bonn, Germany.

Patch-clamp/rapid solution exchange experiments as well as tracer ([14C]-guanidinium) influx measurements were applied to investigate effects of propofol on 5-HT3 receptor channels and compare the results with those obtained with pentobarbital. Currents induced by 30 microM 5-HT were recorded in outside-out patches from N1E-115 cells. Application of propofol 45 s before and during 5-HT application inhibited peak-currents and integrated current responses in a concentration-dependent manner (IC50 values=14. Read More

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Acute stress induces a differential increase of 5-HT-moduline (LSAL) tissue content in various rat brain areas.

Brain Res 1999 Apr;825(1-2):152-60

Unité de Pharmacologie Neuro-immuno-endocrinienne, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France.

5-HT-moduline is an endogenous cerebral tetrapeptide (LSAL) which specifically interacts as an allosteric modulator with 5-HT1B receptors controlling serotonergic activity [O. Massot, J.C. Read More

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Effects of GABAB receptor antagonism on the development of pentylenetetrazol-induced kindling in mice.

Brain Res 1998 Nov;809(2):182-8

Department of Pharmacology and Toxicology, Higher Medical School Plovdiv, Bulgaria.

Pentylenetetrazol (PTZ) administered chronically in rodents induces kindling which is considered to be a model of chronic epilepsy mediated through a specific interaction with the GABA-gated chloride ionophore. PTZ kindling also impairs shuttle-box learning indicating a possible modulation of memory storage [A. Becker, G. Read More

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November 1998
3 Reads

A history of Naunyn-Schmiedeberg's Archives of Pharmacology.

K Starke

Naunyn Schmiedebergs Arch Pharmacol 1998 Jul;358(1):1-109

Pharmakologisches Institut, Freiburg i.Br., Germany.

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Identification and characterisation of heterogeneous somatostatin binding sites in rat distal colonic mucosa.

Naunyn Schmiedebergs Arch Pharmacol 1996 Nov;354(5):543-9

Glaxo Institute of Applied Pharmacology, Department of Pharmacology, University of Cambridge, UK.

We have previously shown that the somatostatin (SRIF) sst2 receptor-selective peptide, BIM-23027, is a potent antisecretory agent in rat isolated distal colonic mucosa (RDCM) and in radioligand binding studies in RDCM membranes, it only maximally inhibited approximately 40% of [125I]-Tyr11-SRIF-14 binding (McKeen ES, Feniuk W, Humphrey PPA (1995) Naunyn-Schmiedeberg's Arch Pharmacol 352:402-411). The aim of this study was to characterise the BIM-23027-sensitive and -insensitive SRIF binding sites in more detail and to compare their properties with those of the recombinant sst2 receptor stably expressed in mouse fibroblast (Ltk-) cells. SRIF-14, SRIF-28, CGP-23996 and D Trp8-SRIF-14 abolished [125I]-Tyr11-SRIF-14 binding (pIC50 values, 8. Read More

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November 1996

Promotion of cell growth by stimulation of cloned human 5-HT1D receptor sites in transfected C6-glial cells is highly sensitive to intrinsic activity at 5-HT1D receptors.

Naunyn Schmiedebergs Arch Pharmacol 1996 Jul;354(2):136-44

Laboratory of Cellular and Molecular Neurobiology, Centre de Recherche Pierre Fabre, Castres, France.

5-Hydroxytryptamine (serotonin, 5-HT), essentially known as a neurotransmitter and vasoactive agent, also functions as a mitogen in various cell types through several different second messenger systems. Stimulation of cloned human 5-HT1D receptor sites by sumatriptan in stably transfected rat C6-glial/5-HT1D cells promotes cell growth (Pauwels et al. (1996) Naunyn-Schmiedeberg's Arch Pharmacol 353:144-156). Read More

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Stimulation of 5-HT3 receptors in the NTS inhibits the cardiac Bezold-Jarisch reflex response.

Am J Physiol 1996 Jul;271(1 Pt 2):H80-7

Institut National de la Santé et de la Recherche Médicale Unitè 288, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France.

Intra-atrial administration of phenylbiguanide has been shown to trigger, through the stimulation of vagal afferent C-fibers, reflex bradycardia, hypotension, and sympathoinhibition classically known as the Bezold-Jarisch (B-J) reflex (O. Krayer. Naunyn-Schmiedeberg's Arch. Read More

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July 1996
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Comparison of cloned and pharmacologically defined rat tissue alpha 1-adrenoceptor subtypes.

Naunyn Schmiedebergs Arch Pharmacol 1994 Aug;350(2):136-42

Department of Medicine, University of Essen, Germany.

Multiple alpha 1-adrenoceptor subtypes have been defined by pharmacological and receptor cloning techniques, but the precise alignment of cloned and pharmacologically-defined subtypes is still unclear. We have compared the affinities of 8 subtype-selective compounds at three cloned alpha 1-adrenoceptor subtypes (rat alpha 1B, bovine alpha 1C, rat alpha 1A/D) with those previously determined by the same methods in rat spleen, cerebral cortex, and kidney (Naunyn-Schmiedeberg's Arch. Pharmacol. Read More

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Species and organ differences of sulphate conjugation of p-nitrophenol in liver and platelets.

Chem Pharm Bull (Tokyo) 1992 Jul;40(7):1964-5

Department of Biopharmaceutics, Tokyo College of Pharmacy, Japan.

Sulphate conjugation of p-nitrophenol (p-NP) in the liver and platelet cytosol of guinea pigs, rabbits and dogs were studied. The dependency of phenol sulphotransferase (PST) activity on p-NP concentration in the liver of guinea pigs and rabbits and in the platelets of guinea pigs were similar to that reported for the liver (Mizuma et al., J. Read More

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Positive and negative contractile effects of neuropeptide Y on ventricular cardiomyocytes.

Am J Physiol 1991 Dec;261(6 Pt 2):H1727-33

Department of Therapeutics and Pharmacology, Queen's University of Belfast, United Kingdom.

The potency of neuropeptide Y (NPY) to cause negative and positive contractile responses in rat ventricular cardiomyocytes was investigated. In these cells, NPY was found to activate the transient outward K+ current (Ito) and the slow inward Ca2+ current (Isi). As reported before (H. Read More

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December 1991

Competitive antagonism by recognized 5-HT2 receptor antagonists at 5-HT1C receptors in pig choroid plexus.

Naunyn Schmiedebergs Arch Pharmacol 1991 Aug;344(2):137-42

Department of Pharmacology, School of Pharmacy, Hacettepe University, Ankara, Turkey.

The effects of several antagonists, known to interact with 5-HT2 receptors (ritanserin, LY 53857, ICI 169,369, methysergide, mesulergine and ketanserin), were tested against 5-HT-stimulated production of inositol phosphate in pig choroid plexus, a 5-HT1C receptor model. These antagonists produced dextral shifts of the concentration response curve to 5-HT in a parallel manner, without depressing significantly the maximal response. The following pA2 values (in parentheses) were obtained: mesulergine (8. Read More

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The steady-state concentration gradient for 3H-noradrenaline generated by uptake1 in the extracellular space of the rat vas deferens incubated with this amine.

Naunyn Schmiedebergs Arch Pharmacol 1991 Jul;344(1):41-6

Institut für Pharmakologie und Toxikologie, Universität Würzburg, Federal Republic of Germany.

The rat vas deferens was incubated with 0.2 mumol/l 3H-noradrenaline for 60 min, washed out with amine-free solution for 100 min and then prepared for autoradiography (same tissues as presented by Azevedo et al. (1990) Naunyn-Schmiedeberg's Arch Pharmacol 342:245-248). Read More

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Iodipamide uptake by rat liver plasma membrane vesicles enriched in the sinusoidal fraction: evidence for a carrier-mediated transport dependent on membrane potential.

Biochim Biophys Acta 1986 Feb;855(1):157-68

Iodipamide, a cholecystographic agent, is known to be taken up by isolated hepatocytes by a mechanism similar or identical with the inward transport of bile salts (Petzinger, E., Joppen, C. and Frimmer, M. Read More

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February 1986

Palytoxin-induced permeability changes in excitable membranes.

Biochim Biophys Acta 1985 Aug;818(1):55-60

Palytoxin, a toxin isolated from the Caribean corrall Palythoa caribaeorum, increases the cation permeability of excitable membranes in vitro. Three membrane systems have been investigated: axonal membranes from crayfish walking leg nerves, membranes rich in nicotinic acetylcholine receptor isolated from Torpedo californica electric tissue and, for control, artificial liposomes. Ion permeability of the latter was not affected by palytoxin, but with both biological membranes an increase in cation permeability was observed at a palytoxin concentration of 0. Read More

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Further characterization of membrane proteins involved in the transport of organic anions in hepatocytes. Comparison of two different affinity labels: 4,4'-diisothiocyano-1,2-diphenylethane-2,2'-disulfonic acid and brominated taurodehydrocholic acid.

Biochim Biophys Acta 1984 Jan;769(1):117-29

4,4'-Diisothiocyano-1,2-diphenylethane-2,2'-disulfonic acid (H2DIDS) known as an irreversible inhibitor of the anion transport in red blood cells (Cabantchik, Z.I. and Rothstein, A. Read More

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January 1984

Transport of organic ions through lipid bilayers. The barbiturates.

P G Ruifrok

Naunyn Schmiedebergs Arch Pharmacol 1982 Jun;319(3):185-8

In a previous article [Naunyn-Schmiedeberg's Arch Pharmacol (1981) 316:266-272] transport of a number of organic ions across lipid bilayers was investigated using single bilayer liposomes. In this investigation the translocation of structurally closely related barbiturates across lipid bilayers is studied. The anionic form of the barbiturates can pass lipid bilayers, provided that the lipophilicity of the 5,5-disubstituted side chain is high enough. Read More

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[Recommendations of the German Society for Clinical Chemistry. Performance of clinical-chemical tests on pharmaceuticals (author's transl)].

J Büttner

J Clin Chem Clin Biochem 1976 Mar;14(3):161-4

In the Federal Republic of Germany, the recommendations of professional bodies for the testing of pharmaceuticals, which were published rather a long time ago, do not refer to clinical-chemical investigations (Report of the executive committee of the German Pharmacological Society and the Commission for the establishment of guide lines for the testing of pharmaceuticals, Naunyn-Schmiedeberg's Arch. Exp. Pathol. Read More

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