8,463 results match your criteria Naunyn-Schmiedeberg's Archives of Pharmacology[Journal]


Antidepressant-like effect and toxicological parameters of extract and withanolides isolated from aerial parts of Solanum capsicoides All. (Solanaceae).

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 13. Epub 2019 Apr 13.

Programa de Pós-Graduação em Ciências Farmacêuticas and Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí - UNIVALI, Rua Uruguai, 458, Itajaí, Santa Catarina, 88303-901, Brazil.

The present work describes the evaluation of the antidepressant-like activity of the extract, fractions, and compounds obtained from the aerial parts of Solanum capsicoides. The methanolic extract (MESC) obtained by conventional maceration was partitioned with solvents of increasing polarities yielding the respective fractions of hexane (HE), dichloromethane (DCM), and ethyl acetate (EA). The dichloromethane and ethyl acetate fractions were submitted to chromatographic and spectroscopic techniques, leading to the isolation and identification of cilistadiol (1), astragalin (2), and cilistol A (3). Read More

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http://dx.doi.org/10.1007/s00210-019-01648-9DOI Listing

A new cationic palladium(II) dithiocarbamate exhibits anti-inflammatory, analgesic, and antipyretic activities through inhibition of inflammatory mediators in in vivo models.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 9. Epub 2019 Apr 9.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Inflammation is being a protective mechanism of the body towards the injury. However, chronic and progressive inflammation may lead to some chronic diseases. Due to the serious unwanted effects associated with available drugs, new and safe anti-inflammatory agents are still required. Read More

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http://dx.doi.org/10.1007/s00210-019-01645-yDOI Listing
April 2019
1 Read
2.471 Impact Factor

Activation of orexinergic and histaminergic pathway involved in therapeutic effect of histamine H receptor antagonist against cisplatin-induced anorexia in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 27. Epub 2019 Mar 27.

Professor Emeritus, Osaka University, Yamadaoka 1-1, Suita, Osaka, 565-0871, Japan.

We previously reported that hypothalamic tumor necrosis factor-alpha (TNF-α) mRNA expression via histamine H receptors contributes to the development of cisplatin-induced anorexia; however, its precise mechanisms remain unclear. It has been reported that chemotherapeutic agents induce the suppression of orexin neuron activity, and the administration of orexin inhibits chemotherapeutic agent-induced gastric discomfort. Other studies demonstrated that the central administration of TNF-α impairs the orexinergic system, and that orexin excites the histaminergic system. Read More

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http://dx.doi.org/10.1007/s00210-019-01646-xDOI Listing

Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 27. Epub 2019 Mar 27.

Laboratory of Animal Biology, National Institute for Research and Development for Biology and Animal Nutrition, Calea Bucuresti No. 1, 077015, Balotesti, Ilfov, Romania.

Zearalenone (ZEA), a mycotoxin produced by several Fusarium spp., is most commonly found as a contaminant in stored grain. ZEA derivatives (α-zearalenol (α-ZOL), β-zearalenol (β-ZOL)) can also be produced by Fusarium spp. Read More

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http://dx.doi.org/10.1007/s00210-019-01644-zDOI Listing
March 2019
2 Reads

Pinacidil, a KATP channel opener, stimulates cardiac Na/Ca exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 27. Epub 2019 Mar 27.

Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.

Pinacidil, a nonselective ATP-sensitive K (KATP) channel opener, has cardioprotective effects for hypertension, ischemia/reperfusion injury, and arrhythmia. This agent abolishes early afterdepolarizations, delayed afterdepolarizations (DADs), and abnormal automaticity in canine cardiac ventricular myocytes. DADs are well known to be caused by the Na/Ca exchange current (I). Read More

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http://dx.doi.org/10.1007/s00210-019-01642-1DOI Listing

Involvement of glucocorticoid and mineralocorticoid receptors in lipid accumulation and depressed G6PD activity in the livers of rats treated with postpartum oral estrogen-progestin.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 23. Epub 2019 Mar 23.

HOPE Cardiometabolic Research Team and Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240001, Nigeria.

Postpartum contraception is an important step for preventing closely spaced pregnancy. Combined oral contraceptive (COC) has been linked to cardiometabolic disturbances. We therefore hypothesized that postpartum oral estrogen-progestin use induces hepatic lipid accumulation that is associated with glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) activation via adenosine deaminase (ADA)/xanthine oxidase (XO)/uric acid (UA)-dependent pathway. Read More

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http://dx.doi.org/10.1007/s00210-019-01634-1DOI Listing
March 2019
1 Read

Treatment with a brain-selective prodrug of 17β-estradiol improves cognitive function in Alzheimer's disease mice by regulating klf5-NF-κB pathway.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450002, China.

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) which is a brain-selective prodrug of 17β-estradiol has been reported to improve the cognitive function in Alzheimer's disease (AD) mice model. However, little is known about the potential mechanism for cognitive improvement. In the present study, we used AD mice to investigate the effects and mechanisms of DHED treatment. Read More

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http://dx.doi.org/10.1007/s00210-019-01639-wDOI Listing
March 2019
1 Read

The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 13. Epub 2019 Mar 13.

Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

We recently showed that the antiobese efficacy of the AT1 receptor blocker telmisartan (TEL) is at least partially related to an Ang(1-7)-dependent mechanism. Ang(1-7) acts via Mas, thus raising the question of whether Mas-deficient (Mas-ko) mice are likewise predisposed to develop diet-induced obesity and, further, whether this can be prevented by TEL treatment. Mas-ko mice and FVB/N wild-type (wt) animals were treated with TEL (8 mg/kg/day) or vehicle while they were fed with high-fat diet (HFD) or chow. Read More

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http://link.springer.com/10.1007/s00210-019-01643-0
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http://dx.doi.org/10.1007/s00210-019-01643-0DOI Listing
March 2019
3 Reads

Aldosterone stimulation mediates cardiac metabolism remodeling via Sirt1/AMPK signaling in canine model.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 9. Epub 2019 Mar 9.

Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, Youzheng Street 23#, Nangang District, Harbin, 150001, Heilongjiang Province, China.

Aldosterone (Aldo), a pivotal hormone that is ubiquitously expressed in systemic tissues of mammals, is a crucial factor in the pathogenesis of cardiac disease. Accumulating evidence suggests that disturbances in cell energy metabolism are involved in increasing aldosterone levels. However, the precise mechanism underlying the impact of cardiac metabolic remodeling underlying aldosterone stimulation remains limited. Read More

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http://dx.doi.org/10.1007/s00210-019-01641-2DOI Listing
March 2019
2 Reads

Blebbistatin reveals beneficial effects on the cystometric parameters in an animal model of detrusor overactivity.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 9. Epub 2019 Mar 9.

Chair and Department of Applied Pharmacy, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland.

The aims of the study were to determine the effectiveness of blebbistatin (BLEB) on detrusor overactivity (DO) in an animal model induced by retinyl acetate (RA) and, because of potential urothelial permeability, to evaluate the degenerative impact of BLEB on the urothelium. Three days after RA instillation into the urinary bladder, BLEB was administered into the bladder and immediately after cystometric assessment was performed. Furthermore, Evans Blue extravasation into bladder tissue and urothelium thickness were measured. Read More

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http://dx.doi.org/10.1007/s00210-019-01640-3DOI Listing
March 2019
2 Reads

Evaluation of the pharmacological involvement of ATP-sensitive potassium (K) channels in the antidepressant-like effects of topiramate on mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 4. Epub 2019 Mar 4.

Experimental Medicine Research Center, Tehran University of Medical Sciences, P.O. Box13145-784, Tehran, Iran.

Acute doses of topiramate (TPM) have been shown to reduce immobility time in the mice forced swimming test (FST) through inhibition of the nitric oxide (NO) pathway. Adenosine triphosphate-sensitive potassium (K) channels are known to have an active role in depression. This study investigates the potential participation of K channels in the antidepressant-like effect of TPM through the stimulatory effects of NO. Read More

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http://dx.doi.org/10.1007/s00210-019-01636-zDOI Listing
March 2019
2.471 Impact Factor

Antagonism of Ca-sensing receptors by NPS 2143 is transiently masked by p38 activation in mouse brain bEND.3 endothelial cells.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 2. Epub 2019 Mar 2.

Department of Physiology, China Medical University, Taichung, 40402, Taiwan.

Ca-sensing receptors (CaSR) are G protein-coupled receptors which are activated by a rise in extracellular Ca. CaSR activation has been known to inhibit parathyroid hormone release and stimulate calcitonin release from parathyroid glands and thyroid parafollicular C cells, respectively. The roles of CaSR in other cell types including endothelial cells (EC) are much less understood. Read More

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http://dx.doi.org/10.1007/s00210-019-01637-yDOI Listing
March 2019
1 Read

A literature analysis on anti-vascular endothelial growth factor therapy (anti-VEGF) using a bibliometric approach.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 2;392(4):393-403. Epub 2019 Mar 2.

Department of Ophthalmology and Micro-Technology, Yokohama City University, Yokohama, Japan.

We performed the current study to assess the citation performance of research works on anti-vascular endothelial growth factor (anti-VEGF) therapy. We searched Web of Science (WoS) to identify relevant publications and analyze them with reference to their publication year, journal title, citation count, WoS category, and article type. The bibliometric software (VOSviewer) was used for citation analyses of countries and journals and to generate a term map that visualizes the recurring terms appearing in the titles and abstracts of published articles. Read More

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http://link.springer.com/10.1007/s00210-019-01629-y
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http://dx.doi.org/10.1007/s00210-019-01629-yDOI Listing
April 2019
4 Reads
2.471 Impact Factor

Correction to: Protective effects of amifostine, curcumin and melatonin against cisplatin-induced acute kidney injury.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr;392(4):511

Department of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdogan University, 53010, Rize, Turkey.

Due to an oversight, Drug treatment (Material and Methods section) in Mercantepe et al. (2018) Naunyn Schmiedebergs Arch Pharmacol. 2018 Sep;391(9):915-931. Read More

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http://dx.doi.org/10.1007/s00210-019-01633-2DOI Listing

MLC901 during sleep deprivation rescues fear memory disruption in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 28. Epub 2019 Feb 28.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Several lines of evidence suggest that sleep deprivation disrupts cognitive and emotional abilities and changes the expression of distinctive categories of genes in the brain. In the present study, saline- or MLC901 (a traditional Chinese medicine)-treated male Wistar rats were first submitted to a modified water box (for 24-h sleep deprivation) and then trained in contextual and tone fear conditioning tasks with the purpose to evaluate the effect of MLC901 during sleep deprivation on fear memory retention. Hippocampal mRNA measurement was performed by reverse transcription-polymerase chain reaction (RT-PCR). Read More

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http://dx.doi.org/10.1007/s00210-018-01612-zDOI Listing
February 2019

A simple approach to studying cerebral blood flow during psychological stress.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 27;392(4):505-509. Epub 2019 Feb 27.

Laboratory of Applied Neuro-Endocrinology, Badji-Mokhtar University, Annaba, Algeria.

The purpose of this work was to determine, in the Wistar male rats, the role of the stress system in the control of cerebral hemodynamics induced by emotional stress (air jet). Blood flow rates in the internal carotid arteries have been obtained using chronically implanted Doppler probes. In this investigation, air-jet stress provokes a rapid and substantial elevation of blood pressure combined with hyperemia and vasodilation. Read More

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http://dx.doi.org/10.1007/s00210-019-01638-xDOI Listing
April 2019
1 Read

Pharmacological stimulation of sigma-1 receptor promotes activation of astrocyte via ERK1/2 and GSK3β signaling pathway.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 23. Epub 2019 Feb 23.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Astrocyte is considered to be a type of passive supportive cells that preserves neuronal activity and survival. The dysfunction of astrocytes is involved in the pathological processes of major depression. Recent studies implicate sigma-1 receptors as putative therapeutic targets for current available antidepressant drugs. Read More

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http://dx.doi.org/10.1007/s00210-019-01632-3DOI Listing
February 2019

Na/K-ATPase level and products of lipid peroxidation in live cells treated with therapeutic lithium for different periods in time (1, 7, and 28 days); studies of Jurkat and HEK293 cells.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 21. Epub 2019 Feb 21.

Department of Biomathematics, Institute of Physiology of the Czech Academy of Sciences, v.v.i, Videnska 1083, 14220, Prague 4, Czech Republic.

Regulation of Na/K-ATPase in bipolar disorder and lithium therapy has been investigated for more than 40 years. Contradictory results in this area may be caused by the difference between acute and long-term Li effects on cell metabolism and variance in responsiveness of different cell types. We compared the time-course of Li action focusing on Na/K-ATPase and lipid peroxidation in two widely different cell models-Jurkat and HEK293. Read More

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http://dx.doi.org/10.1007/s00210-019-01631-4DOI Listing
February 2019
1 Read

Mineralocorticoid receptor blockade attenuates disrupted glutathione-dependent antioxidant defense and elevated endoglin in the hearts of pregnant rats exposed to testosterone.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240003, Nigeria.

Elevated testosterone during late pregnancy has been linked to cardiac dysfunction and poor pregnancy outcomes. The role of mineralocorticoid receptor (MR) in testosterone-induced cardiac dysfunction has not been fully elucidated. The study was therefore designed to investigate the role of MR on gestational excess androgen-induced cardiac disrupted glutathione-dependent antioxidant system and elevated endoglin (Eng) linking it with pregnancy outcomes. Read More

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http://dx.doi.org/10.1007/s00210-019-01630-5DOI Listing
February 2019
1 Read

New arylpiperazine derivatives with antidepressant-like activity containing isonicotinic and picolinic nuclei: evidence for serotonergic system involvement.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.

Therapy of depression is difficult and still insufficient despite the presence of many antidepressants on the market. Therefore, there is a constant need to search for new, safer, and more effective drugs that could be used in the treatment of depression. Among many methods, chemical modification is an important strategy for new drug development. Read More

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http://dx.doi.org/10.1007/s00210-019-01620-7DOI Listing
February 2019

Analgesic effects of mirogabalin, a novel ligand for αδ subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Pain & Neuroscience Laboratories, Daiichi-Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.

Mirogabalin, a novel ligand for the αδ subunit of voltage-gated calcium channels, is under the development for the treatment of neuropathic pain. Mirogabalin specifically and potently binds to αδ subunits, and it shows analgesic effects in both peripheral and central neuropathic pain models in rats. To expand pharmacological findings on mirogabalin and provide additional information of its potential for chronic pain therapy, we examined the effects of mirogabalin in 2 experimental models of fibromyalgia, namely, the intermittent cold stress model (ICS model) and the unilateral intramuscular acidic saline injection model (Sluka model). Read More

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http://dx.doi.org/10.1007/s00210-019-01628-zDOI Listing
February 2019
3 Reads

Abiraterone acetate exerts a cytotoxic effect in human prostate cancer cell lines.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, V.le Europa 11, 25123, Brescia, Italy.

To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. T877A-AR-LNCaP, WT-AR-VCaP, AR-negative DU145, and PC3 PCa cell lines were used by MTT and cell count to study the ability of AER and enzalutamide (ENZ) to modify cell viability. The role of ARs in LNCaP was demonstrated through a gene-silencing experiment. Read More

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http://dx.doi.org/10.1007/s00210-019-01622-5DOI Listing
February 2019
3 Reads

Glucagon-like peptide-1 attenuates endoplasmic reticulum stress-induced apoptosis in H9c2 cardiomyocytes during hypoxia/reoxygenation through the GLP-1R/PI3K/Akt pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Affiliated Hospital of Jiujiang University, Jiujiang, 332000, Jiangxi Province, China.

Endoplasmic reticulum (ER) stress-induced apoptosis is a major cause of myocardial ischemia/reperfusion (I/R) injury. Emerging evidence indicates that glucagon-like peptide-1 (GLP-1) has potential cardioprotective effects. However, the precise mechanisms underlying the involvement of GLP-1 in I/R injury remain largely unknown. Read More

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http://dx.doi.org/10.1007/s00210-019-01625-2DOI Listing
February 2019
1 Read

Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer's disease and type 2 diabetes.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

There is increasing evidence of a link between type 2 diabetes mellitus (T2DM) and cognitive decline. T2DM has been recognized as a risk factor for Alzheimer's disease (AD). The aim of this research was to investigate the biochemical and physiological effects of vildagliptin treatment alone, and in combination with memantine, in a rat model of combined T2DM and AD. Read More

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http://dx.doi.org/10.1007/s00210-019-01616-3DOI Listing
February 2019
2 Reads

Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.

Painful diabetic neuropathy (PDN) is known to adversely affect psychosocial functioning by enhancing levels of anxiety and depression. This study was designed to verify the antihypernociceptive, anxiolytic, and antidepressant-like effects of Combretin A and Combretin B (two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans) in streptozotocin-induced diabetic neuropathy in mice. PDN was induced in mice by the administration of streptozotocin (STZ, 200 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-019-01626-1DOI Listing
February 2019
6 Reads
2.471 Impact Factor

Pentoxifylline ameliorates chronic stress/high-fat diet-induced vascular wall disease: the role of circulating endothelial progenitor cells.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Depression and cardiovascular disease (CVD) are two faces of one coin. A pro-inflammatory state was previously suggested in the pathology of both diseases. We investigated the effect of chronic administration (2 weeks) of imipramine (20 mg/kg/day) and pentoxifylline (50 mg/kg/day) on behavioral, aortic histological abnormalities, and level of circulating endothelial progenitor cells (CEPCs) in peripheral blood of male Wistar rats exposed to chronic mild stress (CMS) and high-fat diet. Read More

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http://link.springer.com/10.1007/s00210-019-01627-0
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http://dx.doi.org/10.1007/s00210-019-01627-0DOI Listing
February 2019
18 Reads
2.471 Impact Factor

Ferulic acid ameliorates doxorubicin-induced cardiac toxicity in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmacology, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, 411041, India.

Ferulic acid (FA) is a phenolic compound with potent antioxidant activity. The objective of the study was to study the protective effects of FA on doxorubicin (Dox)-induced myocardial toxicity in rats. Wistar rats received vehicle (control) or Dox (20 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-019-01623-4DOI Listing
February 2019
2.471 Impact Factor

Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-κB and TGF-β1 pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, P.N. 11754, Egypt.

Doxorubicin (DOX) so far continues to be one of the most potent and effective anticancer drugs. Therefore, it is still needed to search for a safe and effective therapy that can opposite DOX-induced cardiotoxicity. Irbesartan (IRB), an angiotensin II receptor blocker, has a wide-ranging variety of biological activities. Read More

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http://dx.doi.org/10.1007/s00210-019-01624-3DOI Listing
February 2019
2 Reads

Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 6;392(5):593-603. Epub 2019 Feb 6.

The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Inflammation is one of the characteristic features during the development of human tumors. A pro-inflammatory cytokine that is known to promote inflammation during cancer development is the transforming growth factor-β (TGF-β). On the other hand, demethylzeylasteral (T-96) is a natural compound isolated from Tripterygium wilfordii Hook F, which has been reported to have various pharmacological properties including anti-inflammatory and immunosuppressive activities. Read More

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http://dx.doi.org/10.1007/s00210-019-01614-5DOI Listing
May 2019
1 Read
2.471 Impact Factor

Enoxaparin prevents fibrin accumulation in liver tissues and attenuates methotrexate-induced liver injury in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 28;392(5):623-631. Epub 2019 Jan 28.

Faculty of pharmacy, Al-Azhar University, Cairo, Egypt.

Methotrexate (MTX) is a widely used drug for treatment of many malignant, rheumatic, and autoimmune diseases. However, hepatotoxicity remains one of the most serious side effects of MTX. The extrinsic coagulation pathway is activated after tissue injury through the release of tissue factor (TF) which activates a cascade of clotting factors including prothrombin and fibrinogen. Read More

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http://dx.doi.org/10.1007/s00210-019-01618-1DOI Listing
May 2019
4 Reads

S-Adenosylmethionine synergistically enhances the antitumor effect of gemcitabine against pancreatic cancer through JAK2/STAT3 pathway.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 25;392(5):615-622. Epub 2019 Jan 25.

Department of General Surgery, Hepatobiliary surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Gemcitabine (GEM) has been widely used for pancreatic cancer (PC) treatment but limited by the development of drug resistance. The agents that reverse its resistance and improve the chemo-sensitivity are urgently needed. S-Adenosylmethionine (SAM) is a precursor for polyamine biosynthesis in mammalian cells and plays a key role in biological transmethylation events. Read More

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http://dx.doi.org/10.1007/s00210-019-01617-2DOI Listing
May 2019
4 Reads

Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 25;392(5):605-613. Epub 2019 Jan 25.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

It has been demonstrated that activation of autophagy is involved in the development of pulmonary arterial hypertension (PAH). Recent studies have shown that cytosolic forkhead box protein O1 (FoxO1) activates autophagy in cancer cells. Paclitaxel has been found to potentially reverse PAH progression. Read More

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http://dx.doi.org/10.1007/s00210-019-01615-4DOI Listing
May 2019
4 Reads

β-Lapachone protects against doxorubicin-induced nephrotoxicity via NAD/AMPK/NF-kB in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 23;392(5):633-640. Epub 2019 Jan 23.

Drug Applied Research Center, Tabriz University of Medical Sciences, Golgasht Avenue, Tabriz, Iran.

β-Lapachone (B-LAP) is a natural naphtaquinone with established anti-oxidative stress and anti-cancer activities. We aimed to investigate B-LAP protective potential against doxorubicin (DOX)-induced nephrotoxicity in mice. The mice received an oral dose of B-LAP followed by a single intraperitoneal injection of 20 mg/kg DOX a day later. Read More

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http://dx.doi.org/10.1007/s00210-019-01619-0DOI Listing
May 2019
3 Reads
2.471 Impact Factor

Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 17;392(2):123-133. Epub 2019 Jan 17.

School of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.

Opioids are widely administered to alleviate pain, including chronic pain in advanced cancer patients. Among opioids, morphine is one of the most clinically effective drugs for the palliative management of severe pain. In the last few decades, there has been a debate around the possible influence of opioids such as morphine on tumour growth and metastasis. Read More

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http://dx.doi.org/10.1007/s00210-019-01613-6DOI Listing
February 2019
12 Reads

Qiliqiangxin attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in rabbits.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 9;392(5):585-592. Epub 2019 Jan 9.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.

Qiliqiangxin (QL) can attenuate myocardial remodeling and improve cardiac function in some cardiac diseases, including heart failure and hypertension. This study was to explore the effects and mechanism of QL on atrial structural remodeling in atrial fibrillation (AF). Twenty-one rabbits were randomly divided into a sham-operation group, pacing group (pacing with 600 beats per minute for 4 weeks), and treatment group (2. Read More

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http://link.springer.com/10.1007/s00210-018-01611-0
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http://dx.doi.org/10.1007/s00210-018-01611-0DOI Listing
May 2019
13 Reads

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 7;392(5):529-540. Epub 2019 Jan 7.

Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade do Oeste de Santa Catarina - UNOESC, Campus Videira, Rua Paese 180, Videira, SC, 89560-000, Brazil.

Acne vulgaris (AV), a severe chronic inflammatory dermatosis, commonly treated with systemic or topical antibiotics that exacerbate bacterial resistance and pose adverse side effects, new approaches for suppressing or reducing Propionibacterium acnes-induced inflammatory responses and thereby treating AV remain necessary. In response, the goal of our study was to investigate the therapeutic potential of phenolic compounds in the in vivo inflammatory process induced by P. acnes. Read More

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http://dx.doi.org/10.1007/s00210-018-01604-zDOI Listing
May 2019
1 Read

Cariniana domestica fruit peels present topical anti-inflammatory efficacy in a mouse model of skin inflammation.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 7;392(5):513-528. Epub 2019 Jan 7.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Av. Roraima 1000, Camobi, Santa Maria, RS, 97105-900, Brazil.

To investigate the topical anti-inflammatory activity of the crude extract of Cariniana domestica fruit peels (CdE), its dichloromethane, n-butanol, and ethyl acetate (EtAc) fractions, and steroids (β-sitosterol, lupeol, and stigmasterol) isolated from the EtAc fraction in models of irritant contact dermatitis (ICD) croton oil-induced in mice. We induced skin inflammation by single (acute; 1 mg/ear) and multiple (chronic; 0.4 mg/ear) croton oil application. Read More

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http://dx.doi.org/10.1007/s00210-018-1594-1DOI Listing
May 2019
3 Reads

Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 6;392(5):573-583. Epub 2019 Jan 6.

Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil.

Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain. Plain lidocaine (LDC) and complexed lidocaine (LDC:HP-β-CD) were initially evaluated in vitro to determine the release rate of the two formulations. Subsequently, the effect of both formulations was evaluated in independent groups of rats submitted to the orofacial formalin test, induction of facial heat hyperalgesia by capsaicin and carrageenan, and induction of facial heat and mechanical hyperalgesia by constriction of the infraorbital nerve. Read More

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http://dx.doi.org/10.1007/s00210-018-01609-8DOI Listing
May 2019
1 Read

All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 4;392(2):159-164. Epub 2019 Jan 4.

Department of Urology, Tepecik Training and Research Hospital, Yenişehir Mah, Gaziler Cad. No:468, Konak, 35100, İzmir, Turkey.

The aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1 ml/kg saline intra-peritoneally (IP) during 10 days. Read More

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http://link.springer.com/10.1007/s00210-018-01603-0
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http://dx.doi.org/10.1007/s00210-018-01603-0DOI Listing
February 2019
20 Reads

Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 4;392(5):541-550. Epub 2019 Jan 4.

School of Life Sciences, Devi Ahilya University, Indore, India.

Thyrotoxicosis is a clinical syndrome that commonly results from excess secretion and/or release of thyroid hormones in the circulation. It affects most of the body systems and if not treated properly may lead to serious health problems. In this investigation, we isolated a phenolic compound, chavibetol (CHV) from Piper betel leaf and evaluated its possible ameliorative effects in thyrotoxicosis of rats. Read More

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http://dx.doi.org/10.1007/s00210-018-01606-xDOI Listing
May 2019
5 Reads

Pharmacokinetic behaviors of ligustrazine after single- and multiple-dose intravenous Shenxiong glucose injection in rats by high-performance liquid chromatography.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 4;392(5):565-572. Epub 2019 Jan 4.

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China.

Shenxiong glucose injection (SXG) is a traditional Chinese medicine that is used for cardio-cerebral vascular diseases on the national essential drug list of China. To date, a comprehensive knowledge concerning the pharmacokinetic profile of SXG-related components, especially following multiple dosing, is still lacking. This study was designed to investigate the pharmacokinetics and tissue distribution of ligustrazine after single- and multiple-dose intravenous administration of SXG in rats. Read More

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http://dx.doi.org/10.1007/s00210-018-01608-9DOI Listing
May 2019
4 Reads

Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma.

Naunyn Schmiedebergs Arch Pharmacol 2019 May 4;392(5):551-563. Epub 2019 Jan 4.

The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266071, Shandong, China.

Clear cell renal cell carcinoma (ccRCC) is the most common type of human malignancies of the urological system. Soyasapogenol B (Soy B), an ingredient of soybean, has been found to exert anti-proliferative activities in vitro in human breast cancer cells. Our current study aimed to evaluate the effectiveness of Soy B against ccRCC. Read More

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http://dx.doi.org/10.1007/s00210-018-01607-wDOI Listing
May 2019
3 Reads

Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 3;392(4):497-504. Epub 2019 Jan 3.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, Scotland, EH8 9XD, UK.

In mammals, nine genes encode trans-membrane adenylyl cyclase (tmAC) isoforms that synthesize the intracellular messenger compound cAMP from ATP. As cAMP is produced in virtually all types of cell, isoform-selective modulators of tmAC would have major research and therapeutic potential. This study investigated the effects of fungicide imidazoles previously shown to suppress cAMP production in various tissues on the activities of tmAC isoforms AC1, 2, or 9 stably expressed in human embryonic kidney 293 cells. Read More

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http://dx.doi.org/10.1007/s00210-018-01610-1DOI Listing
April 2019
1 Read

The inhibitory effects of mitragynine on P-glycoprotein in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 2;392(4):481-496. Epub 2019 Jan 2.

Advanced Medical & Dental Institute, Universiti Sains Malaysia, SAINS@BERTAM, Kepala Batas, Pulau Pinang, Malaysia.

Mitragynine is a major component isolated from Mitragyna speciosa Korth or kratom, a medicinal plant known for its opiate-like and euphoric properties. Multiple toxicity and fatal cases involving mitragynine or kratom have been reported but the underlying causes remain unclear. P-glycoprotein (P-gp) is a multidrug transporter which modulates the pharmacokinetics of xenobiotics and plays a key role in mediating drug-drug interactions. Read More

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http://link.springer.com/10.1007/s00210-018-01605-y
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http://dx.doi.org/10.1007/s00210-018-01605-yDOI Listing
April 2019
2 Reads

Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 17;392(4):467-480. Epub 2018 Dec 17.

Precision medical center, Shanxi Province People's Hospital, Taiyuan, China.

Glucose-regulated protein 78 (GRP78) often highly expresses in a wide range of tumors, which plays promotive functions due to its diversity of location in the development of tumor. Particularly, GRP78 can be secreted into microenvironment by tumor cells through the pathway of exosome, which promotes proliferation, angiogenesis, and drug resistance in cancer cells. Hence, we discovered a potential inhibitor to block GRP78 secretion. Read More

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http://dx.doi.org/10.1007/s00210-018-1585-2DOI Listing
April 2019
3 Reads

Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 15;392(4):451-459. Epub 2018 Dec 15.

Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, 305-8585, Japan.

Prostaglandins (PGs) are important lipid mediators of numerous physiologic and pathophysiologic processes in the kidney. PGE, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. We investigated the renoprotective properties of the novel PGE EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized rats, a chronic kidney disease (CKD) model. Read More

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http://link.springer.com/10.1007/s00210-018-01600-3
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http://dx.doi.org/10.1007/s00210-018-01600-3DOI Listing
April 2019
28 Reads

Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 15;392(4):461-466. Epub 2018 Dec 15.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Combining bortezomib with other anti-cancer drugs or glucocorticoids is more efficient in multiple myeloma than bortezomib alone. However, the molecular mechanism of this beneficial effect is largely unknown. To investigate the effects of these compounds on bortezomib's anti-proliferative potency and its intracellular accumulation and potency to inhibit the chymotrypsin-like proteasomal subunit, seven myeloma cell lines were investigated after exposure to bortezomib alone or either combined with adriamycin plus dexamethasone (PAD regimen) or melphalan plus prednisolone (VMP regimen), respectively. Read More

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http://dx.doi.org/10.1007/s00210-018-01602-1DOI Listing
April 2019
1 Read

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 14;392(4):437-450. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

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http://dx.doi.org/10.1007/s00210-018-01599-7DOI Listing
April 2019
6 Reads

Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production.

Naunyn Schmiedebergs Arch Pharmacol 2019 Apr 13;392(4):427-436. Epub 2018 Dec 13.

Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.

ATP depletion induced by inhibiting glycolysis or mitochondrial ATP production has been demonstrated to cause cancer cell death. Whether ATP depletion can enhance the efficacy and potency of anti-cancer effects of herbal compounds is so far unknown. We examined the enhancing effect of ATP depletion on anti-cancer actions of tetrandrine (TET) in human lung carcinoma A549 cells. Read More

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http://dx.doi.org/10.1007/s00210-018-01601-2DOI Listing
April 2019
3 Reads
2.471 Impact Factor