8,445 results match your criteria Naunyn-Schmiedeberg's Archives of Pharmacology[Journal]


Mineralocorticoid receptor blockade attenuates disrupted glutathione-dependent antioxidant defense and elevated endoglin in the hearts of pregnant rats exposed to testosterone.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515, Ilorin, 240003, Nigeria.

Elevated testosterone during late pregnancy has been linked to cardiac dysfunction and poor pregnancy outcomes. The role of mineralocorticoid receptor (MR) in testosterone-induced cardiac dysfunction has not been fully elucidated. The study was therefore designed to investigate the role of MR on gestational excess androgen-induced cardiac disrupted glutathione-dependent antioxidant system and elevated endoglin (Eng) linking it with pregnancy outcomes. Read More

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http://dx.doi.org/10.1007/s00210-019-01630-5DOI Listing
February 2019

New arylpiperazine derivatives with antidepressant-like activity containing isonicotinic and picolinic nuclei: evidence for serotonergic system involvement.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, Chodźki 4a, 20-093, Lublin, Poland.

Therapy of depression is difficult and still insufficient despite the presence of many antidepressants on the market. Therefore, there is a constant need to search for new, safer, and more effective drugs that could be used in the treatment of depression. Among many methods, chemical modification is an important strategy for new drug development. Read More

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http://dx.doi.org/10.1007/s00210-019-01620-7DOI Listing
February 2019

Analgesic effects of mirogabalin, a novel ligand for αδ subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Pain & Neuroscience Laboratories, Daiichi-Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan.

Mirogabalin, a novel ligand for the αδ subunit of voltage-gated calcium channels, is under the development for the treatment of neuropathic pain. Mirogabalin specifically and potently binds to αδ subunits, and it shows analgesic effects in both peripheral and central neuropathic pain models in rats. To expand pharmacological findings on mirogabalin and provide additional information of its potential for chronic pain therapy, we examined the effects of mirogabalin in 2 experimental models of fibromyalgia, namely, the intermittent cold stress model (ICS model) and the unilateral intramuscular acidic saline injection model (Sluka model). Read More

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http://dx.doi.org/10.1007/s00210-019-01628-zDOI Listing
February 2019
2 Reads

Abiraterone acetate exerts a cytotoxic effect in human prostate cancer cell lines.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, V.le Europa 11, 25123, Brescia, Italy.

To study the capability of the CYP17A1 inhibitor abiraterone acetate (AER) to antagonize the androgen receptor (AR) activation in human prostate cancer (PCa) cell lines. T877A-AR-LNCaP, WT-AR-VCaP, AR-negative DU145, and PC3 PCa cell lines were used by MTT and cell count to study the ability of AER and enzalutamide (ENZ) to modify cell viability. The role of ARs in LNCaP was demonstrated through a gene-silencing experiment. Read More

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http://dx.doi.org/10.1007/s00210-019-01622-5DOI Listing
February 2019
1 Read

Glucagon-like peptide-1 attenuates endoplasmic reticulum stress-induced apoptosis in H9c2 cardiomyocytes during hypoxia/reoxygenation through the GLP-1R/PI3K/Akt pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Affiliated Hospital of Jiujiang University, Jiujiang, 332000, Jiangxi Province, China.

Endoplasmic reticulum (ER) stress-induced apoptosis is a major cause of myocardial ischemia/reperfusion (I/R) injury. Emerging evidence indicates that glucagon-like peptide-1 (GLP-1) has potential cardioprotective effects. However, the precise mechanisms underlying the involvement of GLP-1 in I/R injury remain largely unknown. Read More

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http://dx.doi.org/10.1007/s00210-019-01625-2DOI Listing
February 2019
1 Read

Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer's disease and type 2 diabetes.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.

There is increasing evidence of a link between type 2 diabetes mellitus (T2DM) and cognitive decline. T2DM has been recognized as a risk factor for Alzheimer's disease (AD). The aim of this research was to investigate the biochemical and physiological effects of vildagliptin treatment alone, and in combination with memantine, in a rat model of combined T2DM and AD. Read More

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http://dx.doi.org/10.1007/s00210-019-01616-3DOI Listing
February 2019
1 Read

Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.

Painful diabetic neuropathy (PDN) is known to adversely affect psychosocial functioning by enhancing levels of anxiety and depression. This study was designed to verify the antihypernociceptive, anxiolytic, and antidepressant-like effects of Combretin A and Combretin B (two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans) in streptozotocin-induced diabetic neuropathy in mice. PDN was induced in mice by the administration of streptozotocin (STZ, 200 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-019-01626-1DOI Listing
February 2019
1 Read

Pentoxifylline ameliorates chronic stress/high-fat diet-induced vascular wall disease: the role of circulating endothelial progenitor cells.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 9. Epub 2019 Feb 9.

Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Depression and cardiovascular disease (CVD) are two faces of one coin. A pro-inflammatory state was previously suggested in the pathology of both diseases. We investigated the effect of chronic administration (2 weeks) of imipramine (20 mg/kg/day) and pentoxifylline (50 mg/kg/day) on behavioral, aortic histological abnormalities, and level of circulating endothelial progenitor cells (CEPCs) in peripheral blood of male Wistar rats exposed to chronic mild stress (CMS) and high-fat diet. Read More

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http://link.springer.com/10.1007/s00210-019-01627-0
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http://dx.doi.org/10.1007/s00210-019-01627-0DOI Listing
February 2019
8 Reads
2.471 Impact Factor

Ferulic acid ameliorates doxorubicin-induced cardiac toxicity in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pharmacology, Sinhgad Institute of Pharmacy, Narhe, Pune, Maharashtra, 411041, India.

Ferulic acid (FA) is a phenolic compound with potent antioxidant activity. The objective of the study was to study the protective effects of FA on doxorubicin (Dox)-induced myocardial toxicity in rats. Wistar rats received vehicle (control) or Dox (20 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-019-01623-4DOI Listing
February 2019
2.471 Impact Factor

Irbesartan suppresses cardiac toxicity induced by doxorubicin via regulating the p38-MAPK/NF-κB and TGF-β1 pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, P.N. 11754, Egypt.

Doxorubicin (DOX) so far continues to be one of the most potent and effective anticancer drugs. Therefore, it is still needed to search for a safe and effective therapy that can opposite DOX-induced cardiotoxicity. Irbesartan (IRB), an angiotensin II receptor blocker, has a wide-ranging variety of biological activities. Read More

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http://dx.doi.org/10.1007/s00210-019-01624-3DOI Listing
February 2019
1 Read

Demethylzeylasteral (T-96) inhibits triple-negative breast cancer invasion by blocking the canonical and non-canonical TGF-β signaling pathways.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 6. Epub 2019 Feb 6.

The First Clinical Medical College, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Inflammation is one of the characteristic features during the development of human tumors. A pro-inflammatory cytokine that is known to promote inflammation during cancer development is the transforming growth factor-β (TGF-β). On the other hand, demethylzeylasteral (T-96) is a natural compound isolated from Tripterygium wilfordii Hook F, which has been reported to have various pharmacological properties including anti-inflammatory and immunosuppressive activities. Read More

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http://dx.doi.org/10.1007/s00210-019-01614-5DOI Listing
February 2019

Enoxaparin prevents fibrin accumulation in liver tissues and attenuates methotrexate-induced liver injury in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 28. Epub 2019 Jan 28.

Faculty of pharmacy, Al-Azhar University, Cairo, Egypt.

Methotrexate (MTX) is a widely used drug for treatment of many malignant, rheumatic, and autoimmune diseases. However, hepatotoxicity remains one of the most serious side effects of MTX. The extrinsic coagulation pathway is activated after tissue injury through the release of tissue factor (TF) which activates a cascade of clotting factors including prothrombin and fibrinogen. Read More

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http://dx.doi.org/10.1007/s00210-019-01618-1DOI Listing
January 2019
2 Reads

S-Adenosylmethionine synergistically enhances the antitumor effect of gemcitabine against pancreatic cancer through JAK2/STAT3 pathway.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 25. Epub 2019 Jan 25.

Department of General Surgery, Hepatobiliary surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Gemcitabine (GEM) has been widely used for pancreatic cancer (PC) treatment but limited by the development of drug resistance. The agents that reverse its resistance and improve the chemo-sensitivity are urgently needed. S-Adenosylmethionine (SAM) is a precursor for polyamine biosynthesis in mammalian cells and plays a key role in biological transmethylation events. Read More

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http://dx.doi.org/10.1007/s00210-019-01617-2DOI Listing
January 2019
3 Reads

Paclitaxel alleviates monocrotaline-induced pulmonary arterial hypertension via inhibition of FoxO1-mediated autophagy.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 25. Epub 2019 Jan 25.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

It has been demonstrated that activation of autophagy is involved in the development of pulmonary arterial hypertension (PAH). Recent studies have shown that cytosolic forkhead box protein O1 (FoxO1) activates autophagy in cancer cells. Paclitaxel has been found to potentially reverse PAH progression. Read More

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http://dx.doi.org/10.1007/s00210-019-01615-4DOI Listing
January 2019
1 Read

β-Lapachone protects against doxorubicin-induced nephrotoxicity via NAD/AMPK/NF-kB in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 23. Epub 2019 Jan 23.

Drug Applied Research Center, Tabriz University of Medical Sciences, Golgasht Avenue, Tabriz, Iran.

β-Lapachone (B-LAP) is a natural naphtaquinone with established anti-oxidative stress and anti-cancer activities. We aimed to investigate B-LAP protective potential against doxorubicin (DOX)-induced nephrotoxicity in mice. The mice received an oral dose of B-LAP followed by a single intraperitoneal injection of 20 mg/kg DOX a day later. Read More

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http://dx.doi.org/10.1007/s00210-019-01619-0DOI Listing
January 2019
2 Reads
2.471 Impact Factor

Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 17;392(2):123-133. Epub 2019 Jan 17.

School of Pharmacy and Medical Sciences, and University of South Australia Cancer Research Institute, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.

Opioids are widely administered to alleviate pain, including chronic pain in advanced cancer patients. Among opioids, morphine is one of the most clinically effective drugs for the palliative management of severe pain. In the last few decades, there has been a debate around the possible influence of opioids such as morphine on tumour growth and metastasis. Read More

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http://dx.doi.org/10.1007/s00210-019-01613-6DOI Listing
February 2019
7 Reads

Qiliqiangxin attenuates atrial structural remodeling in prolonged pacing-induced atrial fibrillation in rabbits.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.

Qiliqiangxin (QL) can attenuate myocardial remodeling and improve cardiac function in some cardiac diseases, including heart failure and hypertension. This study was to explore the effects and mechanism of QL on atrial structural remodeling in atrial fibrillation (AF). Twenty-one rabbits were randomly divided into a sham-operation group, pacing group (pacing with 600 beats per minute for 4 weeks), and treatment group (2. Read More

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http://link.springer.com/10.1007/s00210-018-01611-0
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http://dx.doi.org/10.1007/s00210-018-01611-0DOI Listing
January 2019
10 Reads

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 7. Epub 2019 Jan 7.

Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade do Oeste de Santa Catarina - UNOESC, Campus Videira, Rua Paese 180, Videira, SC, 89560-000, Brazil.

Acne vulgaris (AV), a severe chronic inflammatory dermatosis, commonly treated with systemic or topical antibiotics that exacerbate bacterial resistance and pose adverse side effects, new approaches for suppressing or reducing Propionibacterium acnes-induced inflammatory responses and thereby treating AV remain necessary. In response, the goal of our study was to investigate the therapeutic potential of phenolic compounds in the in vivo inflammatory process induced by P. acnes. Read More

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http://dx.doi.org/10.1007/s00210-018-01604-zDOI Listing
January 2019
1 Read

Cariniana domestica fruit peels present topical anti-inflammatory efficacy in a mouse model of skin inflammation.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 7. Epub 2019 Jan 7.

Laboratory Neurotoxicity and Psychopharmacology, Graduate Program in Biological Sciences: Toxicological Biochemistry, Center of Natural and Exact Sciences, Federal University of Santa Maria, Av. Roraima 1000, Camobi, Santa Maria, RS, 97105-900, Brazil.

To investigate the topical anti-inflammatory activity of the crude extract of Cariniana domestica fruit peels (CdE), its dichloromethane, n-butanol, and ethyl acetate (EtAc) fractions, and steroids (β-sitosterol, lupeol, and stigmasterol) isolated from the EtAc fraction in models of irritant contact dermatitis (ICD) croton oil-induced in mice. We induced skin inflammation by single (acute; 1 mg/ear) and multiple (chronic; 0.4 mg/ear) croton oil application. Read More

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http://dx.doi.org/10.1007/s00210-018-1594-1DOI Listing
January 2019
2 Reads

Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 6. Epub 2019 Jan 6.

Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil.

Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain. Plain lidocaine (LDC) and complexed lidocaine (LDC:HP-β-CD) were initially evaluated in vitro to determine the release rate of the two formulations. Subsequently, the effect of both formulations was evaluated in independent groups of rats submitted to the orofacial formalin test, induction of facial heat hyperalgesia by capsaicin and carrageenan, and induction of facial heat and mechanical hyperalgesia by constriction of the infraorbital nerve. Read More

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http://dx.doi.org/10.1007/s00210-018-01609-8DOI Listing
January 2019
1 Read

All-trans retinoic acid prevents cisplatin-induced nephrotoxicity in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 4;392(2):159-164. Epub 2019 Jan 4.

Department of Urology, Tepecik Training and Research Hospital, Yenişehir Mah, Gaziler Cad. No:468, Konak, 35100, İzmir, Turkey.

The aim of this study is to investigate the effects of all-trans retinoic acid (ATRA) use on cisplatin (CP)-induced nephrotoxicty. Twenty-eight rats were randomly divided into four groups. The rats in the control group were injected a single dose of 1 ml/kg saline intra-peritoneally (IP) during 10 days. Read More

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http://link.springer.com/10.1007/s00210-018-01603-0
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http://dx.doi.org/10.1007/s00210-018-01603-0DOI Listing
February 2019
9 Reads

Chavibetol corrects thyrotoxicosis through alterations in thyroid peroxidase.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 4. Epub 2019 Jan 4.

School of Life Sciences, Devi Ahilya University, Indore, India.

Thyrotoxicosis is a clinical syndrome that commonly results from excess secretion and/or release of thyroid hormones in the circulation. It affects most of the body systems and if not treated properly may lead to serious health problems. In this investigation, we isolated a phenolic compound, chavibetol (CHV) from Piper betel leaf and evaluated its possible ameliorative effects in thyrotoxicosis of rats. Read More

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http://dx.doi.org/10.1007/s00210-018-01606-xDOI Listing
January 2019
3 Reads

Pharmacokinetic behaviors of ligustrazine after single- and multiple-dose intravenous Shenxiong glucose injection in rats by high-performance liquid chromatography.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 4. Epub 2019 Jan 4.

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong, China.

Shenxiong glucose injection (SXG) is a traditional Chinese medicine that is used for cardio-cerebral vascular diseases on the national essential drug list of China. To date, a comprehensive knowledge concerning the pharmacokinetic profile of SXG-related components, especially following multiple dosing, is still lacking. This study was designed to investigate the pharmacokinetics and tissue distribution of ligustrazine after single- and multiple-dose intravenous administration of SXG in rats. Read More

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http://dx.doi.org/10.1007/s00210-018-01608-9DOI Listing
January 2019
2 Reads

Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 4. Epub 2019 Jan 4.

The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266071, Shandong, China.

Clear cell renal cell carcinoma (ccRCC) is the most common type of human malignancies of the urological system. Soyasapogenol B (Soy B), an ingredient of soybean, has been found to exert anti-proliferative activities in vitro in human breast cancer cells. Our current study aimed to evaluate the effectiveness of Soy B against ccRCC. Read More

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http://dx.doi.org/10.1007/s00210-018-01607-wDOI Listing
January 2019
3 Reads

Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 3. Epub 2019 Jan 3.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, Scotland, EH8 9XD, UK.

In mammals, nine genes encode trans-membrane adenylyl cyclase (tmAC) isoforms that synthesize the intracellular messenger compound cAMP from ATP. As cAMP is produced in virtually all types of cell, isoform-selective modulators of tmAC would have major research and therapeutic potential. This study investigated the effects of fungicide imidazoles previously shown to suppress cAMP production in various tissues on the activities of tmAC isoforms AC1, 2, or 9 stably expressed in human embryonic kidney 293 cells. Read More

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http://dx.doi.org/10.1007/s00210-018-01610-1DOI Listing
January 2019
1 Read

The inhibitory effects of mitragynine on P-glycoprotein in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 2. Epub 2019 Jan 2.

Advanced Medical & Dental Institute, Universiti Sains Malaysia, SAINS@BERTAM, Kepala Batas, Pulau Pinang, Malaysia.

Mitragynine is a major component isolated from Mitragyna speciosa Korth or kratom, a medicinal plant known for its opiate-like and euphoric properties. Multiple toxicity and fatal cases involving mitragynine or kratom have been reported but the underlying causes remain unclear. P-glycoprotein (P-gp) is a multidrug transporter which modulates the pharmacokinetics of xenobiotics and plays a key role in mediating drug-drug interactions. Read More

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http://link.springer.com/10.1007/s00210-018-01605-y
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http://dx.doi.org/10.1007/s00210-018-01605-yDOI Listing
January 2019
2 Reads

Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 17. Epub 2018 Dec 17.

Precision medical center, Shanxi Province People's Hospital, Taiyuan, China.

Glucose-regulated protein 78 (GRP78) often highly expresses in a wide range of tumors, which plays promotive functions due to its diversity of location in the development of tumor. Particularly, GRP78 can be secreted into microenvironment by tumor cells through the pathway of exosome, which promotes proliferation, angiogenesis, and drug resistance in cancer cells. Hence, we discovered a potential inhibitor to block GRP78 secretion. Read More

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http://dx.doi.org/10.1007/s00210-018-1585-2DOI Listing
December 2018
2 Reads

Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 15. Epub 2018 Dec 15.

Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, 305-8585, Japan.

Prostaglandins (PGs) are important lipid mediators of numerous physiologic and pathophysiologic processes in the kidney. PGE, the most abundant renal PG, plays a major role in renal physiology, including renin release and glomerular hemodynamics. We investigated the renoprotective properties of the novel PGE EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized rats, a chronic kidney disease (CKD) model. Read More

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http://link.springer.com/10.1007/s00210-018-01600-3
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http://dx.doi.org/10.1007/s00210-018-01600-3DOI Listing
December 2018
16 Reads

Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 15. Epub 2018 Dec 15.

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.

Combining bortezomib with other anti-cancer drugs or glucocorticoids is more efficient in multiple myeloma than bortezomib alone. However, the molecular mechanism of this beneficial effect is largely unknown. To investigate the effects of these compounds on bortezomib's anti-proliferative potency and its intracellular accumulation and potency to inhibit the chymotrypsin-like proteasomal subunit, seven myeloma cell lines were investigated after exposure to bortezomib alone or either combined with adriamycin plus dexamethasone (PAD regimen) or melphalan plus prednisolone (VMP regimen), respectively. Read More

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http://dx.doi.org/10.1007/s00210-018-01602-1DOI Listing
December 2018
1 Read

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

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http://dx.doi.org/10.1007/s00210-018-01599-7DOI Listing
December 2018
3 Reads

Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.

ATP depletion induced by inhibiting glycolysis or mitochondrial ATP production has been demonstrated to cause cancer cell death. Whether ATP depletion can enhance the efficacy and potency of anti-cancer effects of herbal compounds is so far unknown. We examined the enhancing effect of ATP depletion on anti-cancer actions of tetrandrine (TET) in human lung carcinoma A549 cells. Read More

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http://dx.doi.org/10.1007/s00210-018-01601-2DOI Listing
December 2018
2 Reads
2.471 Impact Factor

Enhancement of tumor suppressor RAR-β protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 12. Epub 2018 Dec 12.

Department of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu, 641114, India.

Targeting the specific molecular proteins or genes which are responsible for the suppression of cancer growth is currently an emerging molecular method to treat cancer. ATRA treatment is now considered as a molecular targeted therapy for many cancers. As ATRA exhibits its therapeutic effect through its receptors, this study was focused to investigate the effect and action of liposomal-ATRA treatment on the expression of RAR-β protein which is also a tumor suppressor. Read More

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http://dx.doi.org/10.1007/s00210-018-01598-8DOI Listing
December 2018
1 Read

2-Methoxyestradiol attenuates liver fibrosis in mice: implications for M2 macrophages.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 7;392(3):381-391. Epub 2018 Dec 7.

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.

Liver fibrosis is a major health problem worldwide due to its serious complications including cirrhosis and liver cancer. 2-Methoxyestradiol (2-ME) is an end metabolite of estradiol with anti-proliferative, antioxidant, and anti-inflammatory activities. However, the protective role of 2-ME in liver fibrosis has not been fully investigated. Read More

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http://link.springer.com/10.1007/s00210-018-1577-2
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http://dx.doi.org/10.1007/s00210-018-1577-2DOI Listing
March 2019
2 Reads

Side effects of frequently used oral antidiabetics on wound healing in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 7;392(3):371-380. Epub 2018 Dec 7.

Institute of Translational Wound Research, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Stockumer Street 10, 58453, Witten, Germany.

Lifestyle diseases such as diabetes and arteriosclerosis are rising in the increasingly aging society, and the number of patients with daily intake of glucose-lowering medication has also increased. Interestingly, knowledge about oral antidiabetics with regard to wound healing is scarce. Therefore, the aim of this study was to identify possible (side) effects of the most frequently prescribed oral antidiabetics on skin cells and wound healing. Read More

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http://dx.doi.org/10.1007/s00210-018-01597-9DOI Listing
March 2019
3 Reads

Inhibition by general anesthetic propofol of compound action potentials in the frog sciatic nerve and its chemical structure.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 5;392(3):359-369. Epub 2018 Dec 5.

Department of Physiology, Saga Medical School, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Although the intravenous general anesthetic propofol (2,6-diisopropylphenol) has an ability to inhibit nerve conduction, this has not been fully examined. Various agents inhibit compound action potentials (CAPs) in a manner dependent on their chemical structures. To determine propofol's chemical structure that is important in nerve conduction inhibition, we examined the effects of propofol and its related compounds on fast-conducting CAPs recorded from the frog sciatic nerve by using the air-gap method. Read More

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http://dx.doi.org/10.1007/s00210-018-01596-wDOI Listing
March 2019
2 Reads

Astaxanthin ameliorates cardiomyocyte apoptosis after coronary microembolization by inhibiting oxidative stress via Nrf2/HO-1 pathway in rats.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 30;392(3):341-348. Epub 2018 Nov 30.

Department of Cardiology, Tangdu Hospital, Air Force Military Medical University, Xinsi Road, Xi'an, 710000, China.

Coronary microembolization (CME) caused by physical obstruction in coronary microcirculation induces myocardial apoptosis and cardiac dysfunction, and it was reported that the inactivation of the Nrf2/HO-1 signaling was involved in this process. Astaxanthin (AST) is a reddish pigment that belongs to keto-carotenoids. It is also a potent antioxidant and has been reported to activate Nrf2/HO-1 signaling in vein endothelial cells. Read More

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http://dx.doi.org/10.1007/s00210-018-1595-0DOI Listing
March 2019
2 Reads

Etidronate attenuates tactile allodynia by spinal ATP release inhibition in mice with partial sciatic nerve ligation.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 4;392(3):349-357. Epub 2018 Dec 4.

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, 981-8558, Japan.

Etidronate is widely used as a therapeutic agent for osteoporosis. We have recently shown that intrathecal administration of etidronate into mice produces an analgesic effect against the capsaicin-induced nociceptive behavior. However, the effect of etidronate on neuropathic pain at the spinal level remains unknown. Read More

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http://link.springer.com/10.1007/s00210-018-1593-2
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http://dx.doi.org/10.1007/s00210-018-1593-2DOI Listing
March 2019
12 Reads

Impact of elastin-derived VGVAPG peptide on bidirectional interaction between peroxisome proliferator-activated receptor gamma (Pparγ) and beta-galactosidase (β-Gal) expression in mouse cortical astrocytes in vitro.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Department of Clinical Biochemistry and Laboratory Diagnostics, Institute of Medicine, University of Opole, Oleska 48, 45-052, Opole, Poland.

The process of degradation of the elastin-rich extracellular matrix produces elastin-derived peptides (EDPs). Different types of EDPs are detectable in the cerebrospinal fluid in healthy individuals and in patients after ischemic stroke. To date, it has been demonstrated that EDPs can regulate the development of insulin resistance in mice in a peroxisome proliferator-activated receptor gamma (Pparγ)-dependent manner. Read More

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http://link.springer.com/10.1007/s00210-018-1591-4
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http://dx.doi.org/10.1007/s00210-018-1591-4DOI Listing
December 2018
10 Reads

Social behavior effects of diphenyl dimethyl bicarboxylate (DDB) in the sensory contact model.

Authors:
Amal M Mahfoz

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 28;392(3):313-326. Epub 2018 Nov 28.

Department of Pharmacology and Toxicology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Sensory contact model (SCM) permits the evolution of diverse psychopathological states by the repeated antagonistic interactions between male mice. Biphenyl dimethyl dicarboxylate (DDB) is used as a hepatoprotective agent. The present work aimed to study the possible effects of DDB on social behavior developed by SCM by studying its effects on the transformation process to aggressive and submissive behaviors. Read More

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http://link.springer.com/10.1007/s00210-018-1580-7
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http://dx.doi.org/10.1007/s00210-018-1580-7DOI Listing
March 2019
5 Reads

The modulatory role of phloretin in Aβ induced sporadic Alzheimer's disease in rat model.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 28;392(3):327-339. Epub 2018 Nov 28.

Pharmacology Research Laboratory-II, Department of Pharmaceutical Science & Technology, Institute of Chemical Technology (University under Section 3 of UGC Act- 1956, Elite Status & Centre of Excellence-Govt. of Maharashtra, TEQIP Phase II Funded), Matunga (E), Mumbai, Maharashtra, 400019, India.

Alzheimer's disease (AD) is the leading neurodegenerative disorder with extracellular senile plaques and neurofibrillary tangles as the major hallmarks. The objective was to evaluate the effect of phloretin in a chronic model of sporadic AD by injecting aggregated form of Aβ25-35 peptide sequence intracerebroventricularly (icv) in Wistar rats. To achieve this, male Wistar rats were injected with aggregated Aβ25-35 peptide icv, followed by 21 days phloretin (2. Read More

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http://dx.doi.org/10.1007/s00210-018-1588-zDOI Listing
March 2019
14 Reads

Gadolinium chloride attenuates acetic acid-evoked colitis in mice by reducing neutrophil infiltration and pro-oxidative enzyme activity.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 27;392(3):299-311. Epub 2018 Nov 27.

Laboratory of Cell and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene (USTHB), Algiers, Algeria.

This study investigated the potential of gadolinium chloride (GdCl), an inhibitor of kupffer cells on the myeloperoxidase (MPO) function, both in vivo on colon inflammation model and in vitro on thioglycollate-elicited peritoneal neutrophils. Colon inflammation was induced in mice (n = 7) by 4% acetic acid (AA) enema. GdCl (10 mg/kg) treatment was given 24 h before AA challenge. Read More

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http://link.springer.com/10.1007/s00210-018-1592-3
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http://dx.doi.org/10.1007/s00210-018-1592-3DOI Listing
March 2019
2 Reads
2.471 Impact Factor

CCR2 and CCR5 promote diclofenac-induced hepatotoxicity in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 27;392(3):287-297. Epub 2018 Nov 27.

Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, Southern Medical University, Guangzhou, China.

Liver injury, one of the major side effects of diclofenac (DIC), plagues thousands of patients who treated with it. Although involvements of metabolic factors, oxidative stress, and mitochondrial injury have been characterized, the exact immunomolecular mechanism of the hepatotoxicity of DIC still remains ambiguous. In this study, we investigated the role of chemokine receptors CCR2 and CCR5 in this progression. Read More

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http://link.springer.com/10.1007/s00210-018-1576-3
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http://dx.doi.org/10.1007/s00210-018-1576-3DOI Listing
March 2019
10 Reads

Amitriptyline attenuates bleomycin-induced pulmonary fibrosis: modulation of the expression of NF-κβ, iNOS, and Nrf2.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 24;392(3):279-286. Epub 2018 Nov 24.

Biochemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October, Egypt.

Amitriptyline is a tricyclic antidepressant that was suggested to have antifibrotic potential. The current study aimed to investigate the modulatory effects of amitriptyline on bleomycin-induced pulmonary fibrosis in rats. Rats were randomly assigned into 4 groups: normal control, bleomycin control, amitriptyline+bleomycin, and amitriptyline only treated group. Read More

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http://dx.doi.org/10.1007/s00210-018-1586-1DOI Listing
March 2019
5 Reads

Cucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling.

Naunyn Schmiedebergs Arch Pharmacol 2019 Mar 23;392(3):271-278. Epub 2018 Nov 23.

Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Low efficacy and high resistance rate associated with existing chemotherapeutic drugs enforce a requirement for novel therapeutic strategies for extremely aggressive cholangiocarcinoma (CCA). In the present study, the apoptosis-inducing activity of cucurbitacin B, a compound derived from plants of Cucurbitaceae family, against KKU-100 CCA cells and the underlying mechanism mediating its effect were investigated. The results showed that cucurbitacin B significantly decreased CCA cells viability by induction of apoptosis. Read More

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http://dx.doi.org/10.1007/s00210-018-1584-3DOI Listing
March 2019
12 Reads

Lack of thiazide diuretic inhibition of agonist constriction of mouse mesenteric arterioles ex vivo.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 23;392(1):117-121. Epub 2018 Nov 23.

Research Service, Veterans Affairs Medical Center, Cincinnati, OH, 45220, USA.

The chronic reduction of arterial blood pressure by thiazide diuretics (TZD) in hypertensive patients is mediated through an extra-renal mechanism. It is widely held that this extra-renal mechanism is a direct TZD inhibition of vasoconstriction. This study tested whether the TZD, hydrochlorothiazide (HCTZ), inhibited agonist constriction of mesenteric arterioles ex vivo. Read More

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http://dx.doi.org/10.1007/s00210-018-1590-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327843PMC
January 2019
8 Reads

Assessment of spatial learning and memory in the Barnes maze task in rodents-methodological consideration.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 23;392(1):1-18. Epub 2018 Nov 23.

Department of Pharmacology and Pharmacodynamics, Medical University, Chodzki 4a, 20-093, Lublin, Poland.

Among the methods valuable for assessing spatial learning and memory impairments in rodents, the Barnes maze (BM) task deserves special attention. It is based on the assumption that the animal placed into the aversive environment should learn and remember the location of an escape box located below the surface of the platform. Different phases of the task allow to measure spatial learning, memory retrieval, and cognitive flexibility. Read More

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http://dx.doi.org/10.1007/s00210-018-1589-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311199PMC
January 2019
1 Read

Rutin and orlistat produce antitumor effects via antioxidant and apoptotic actions.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 21;392(2):165-175. Epub 2018 Nov 21.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Cancer is a broad term used to describe a large number of diseases characterized by uncontrolled cell proliferation that leads to tumor production. Cancer is associated with mutations in genes controlling proliferation and apoptosis, oxidative stress, fatty acid synthase (FAS) expression, and other mechanisms. Currently, most antineoplastic drugs have severe adverse effects and new effective and safe drugs are needed. Read More

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http://dx.doi.org/10.1007/s00210-018-1579-0DOI Listing
February 2019
24 Reads

Anti-leukemia activity of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 21;392(2):219-227. Epub 2018 Nov 21.

Departamento de Bioquímica, Biología Molecular (B) e Inmunología, School of Medicine, IMIB and Regional Campus of International Excellence "Campus Mare Nostrum", Universidad de Murcia, 30100, Murcia, Spain.

Pteridines are bicyclic heterocyclic compounds with a pyrazino[2,3-d]pyrimidine nucleus that have shown a wide range of therapeutic utilities. Concretely, 4-aminopteridine derivatives have demonstrated both anti-inflammatory and anti-cancer properties, and some of them, such as methotrexate, are profusely used in medical practice. We have recently synthesized and tested the biological activity of a novel series of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines, finding that they present anti-inflammatory properties, as they were able to inhibit in vitro the production of pro-inflammatory cytokines TNF-α and IL-6. Read More

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http://dx.doi.org/10.1007/s00210-018-1587-0DOI Listing
February 2019
14 Reads

Cinnamaldehyde ameliorates STZ-induced rat diabetes through modulation of IRS1/PI3K/AKT2 pathway and AGEs/RAGE interaction.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 20;392(2):243-258. Epub 2018 Nov 20.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.

Type 2 diabetes mellitus (T2D) is a chronic metabolic disorder considered to be the most predominant form of diabetes throughout the world. This study aimed to investigate the possible effects of cinnamaldehyde (CIN) on insulin signaling pathways in STZ-induced T2D rat model. T2D was originated by feeding rats with a high-fat diet (HFD) plus 25% fructose solution plus streptozotocin (STZ) (35 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-018-1583-4DOI Listing
February 2019
11 Reads