26,228 results match your criteria Nature structural & molecular biology[Journal]


BOLD signal variability and complexity in children and adolescents with and without autism spectrum disorder.

Dev Cogn Neurosci 2019 Mar 5;36:100630. Epub 2019 Mar 5.

Rotman Research Institute, Baycrest Hospital, 3560 Bathurst Street, Toronto, ON, M6A 2E1, Canada; Department of Psychology, University of Toronto, 100 St. George Street, Toronto, ON, M5S 3G3, Canada. Electronic address:

Variability of neural signaling is an important index of healthy brain functioning, as is signal complexity, which relates to information processing capacity. Alterations in variability and complexity may underlie certain brain dysfunctions. Here, resting-state fMRI was used to examine variability and complexity in children and adolescents with and without autism spectrum disorder (ASD). Read More

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http://dx.doi.org/10.1016/j.dcn.2019.100630DOI Listing

Naringin nanoparticles against neurodegenerative processes: A preliminary work.

Hell J Nucl Med 2019 Jan-Apr;22 Suppl:32-41

Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

It is well established that during Alzheimer disease (AD), gradual loss of neuronal networks occurs in the brain, consequently, affecting cognition and memory tasks of the patients. Among other causative factors, oxidative stress induces changes that are eventually accompanied by an irreversible disruption of synaptic connectivity and death of neurons. Moreover, aging and oxidative stress cause alterations to the blood brain barrier, leading to increased permeability, which are thought to further aggravate the underlying pathology. Read More

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January 2019

Essay on Biomembrane Structure.

Authors:
Christoph Gerle

J Membr Biol 2019 Mar 15. Epub 2019 Mar 15.

Institute for Protein Research, Osaka University, Suita, Japan.

Of all the macromolecular assemblies of life, the least understood is the biomembrane. This is especially true in regard to its atomic structure. Ideas on biomembranes, developed in the last 200 years, culminated in the fluid mosaic model of the membrane. Read More

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http://dx.doi.org/10.1007/s00232-019-00061-wDOI Listing

Synthesis and encapsulation of V(IV,V) compounds in silica nanoparticles targeting development of antioxidant and antiradical nanomaterials.

J Inorg Biochem 2019 Jan 2;194:180-199. Epub 2019 Jan 2.

Laboratory of Inorganic Chemistry and Advanced Materials, Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece. Electronic address:

The quest for effective treatments of oxidative stress has concentrated over the years on new nanomaterials with improved antioxidant and antiradical activity, thereby attracting broad research interest. In that regard, research efforts in our lab were launched to pursue such hybrid materials involving a) synthesis of silica gel matrices, b) evaluation of the suitability of atoxic matrices as potential carriers for the controlled release of V(IV)(VOSO), V(V)(NaVO) compounds and a newly synthesized heterometallic lithium-vanadium(IV,V) tetranuclear compound containing vanadium-bound hydroxycarboxylic 1,3-diamine-2-propanol-N,N,N',N'-tetraacetic acid (DPOT), and c) investigation of structural and textural properties of silica nanoparticles (NPs) by different and complementary characterization techniques, inquiring into the nature of the encapsulated vanadium species and their interaction with the siloxane matrix, collectively targeting novel antioxidant and antiradical nanomaterials biotechnology. The physicochemical characterization of the vanadium-loaded SiO NPs led to the formulation of optimized material configuration linked to the delivery of the encapsulated antioxidant-antiradical load. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01620134183017
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http://dx.doi.org/10.1016/j.jinorgbio.2018.12.005DOI Listing
January 2019
1 Read

Tunable Direct Band Gap of β-CuGaO and β-LiGaO Solid Solutions in the Full Visible Range.

Inorg Chem 2019 Mar 15. Epub 2019 Mar 15.

Institute of Multidisciplinary Research for Advanced Materials , Tohoku University , 2-1-1 Katahira , Aoba-ku, Sendai , 980-8577 , Japan.

We synthesized solid solutions of β-CuGaO and β-LiGaO (i.e., β-(CuLi )GaO) by partial ion exchange of Cu in β-CuGaO with Li from LiCl in the composition range of 0 ≤ x ≤ 0. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03370DOI Listing

Improvement of an algorithm for displaying multiple images in one space.

Appl Opt 2019 Feb;58(5):A1-A6

Volumetric displays are attracting attention in fields such as media art and digital signage. In previous research, we developed a method to display multiple images in the same space using a volumetric display. However, because of the nature of the algorithm, the images could not be displayed when they contained a pure black image (in which all the pixel values are "0"). Read More

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http://dx.doi.org/10.1364/AO.58.0000A1DOI Listing
February 2019

An Analysis of the World Health Organization Disability Assessment Schedule 2.0 Measurement Model Using Partial Least Squares-Structural Equation Modeling.

Assessment 2019 Mar 15:1073191119834653. Epub 2019 Mar 15.

2 Taylor's University, Subang Jaya, Malaysia.

The researchers examined the factor structure and model specifications of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) with confirmatory tetrad analysis (CTA) using partial least squares-structural equation modeling (PLS-SEM) with a sample of adult clients ( N = 298) receiving individual therapy at a university-based counseling research center. Read More

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http://dx.doi.org/10.1177/1073191119834653DOI Listing

Finite element simulation of the braiding process.

Mech Adv Mater Mod Process 2019 23;5(1). Epub 2019 Jan 23.

Imperial College London, Exhibition Road, London, SW7 2AZ UK.

Braiding is one of the most common technique employed for the manufacture of fabrics and ropes. It is also commonly used to produce near-net shaped preforms for advanced fibre reinforced composites. This paper presents an explicit finite element approach to create and simulate the braiding process for the virtual manufacture of 2D braids. Read More

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https://mammp-journal.springeropen.com/articles/10.1186/s407
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http://dx.doi.org/10.1186/s40759-019-0041-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383729PMC
January 2019
1 Read

Magnetic and electronic properties of magnetite across the high pressure anomaly.

Sci Rep 2019 Mar 14;9(1):4464. Epub 2019 Mar 14.

Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980, Dubna, Russia.

The magnetite FeO, being anciently known magnetic material to human kind and remaining in leading positions for development of advanced technologies presently, demonstrates a number of puzzling physical phenomena, being at focus of extensive research for more than century. Recently the pressure-induced anomalous behavior of physical properties of magnetite in vicinity of the structural phase transition, occurring at P ~ 25-30 GPa, has attracted particular attention, and its nature remains unclear. Here we study the magnetic and electronic properties of magnetite across high pressure anomaly and in the pressure-induced phase by means of Fe synchrotron Moessbauer spectroscopy and neutron diffraction. Read More

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http://dx.doi.org/10.1038/s41598-019-41184-3DOI Listing

Effect of Nb Substitution on the Structural, Magnetic, and Optical Properties of CoNiFe₂O₄ Nanoparticles.

Nanomaterials (Basel) 2019 Mar 13;9(3). Epub 2019 Mar 13.

Department of Physics, Faculty of Science and Letters, Cukurova University, Balcali-Adana 01330, Turkey.

CoNiNbFeO₄ (0.00 ≤ x ≤ 0.10) nanoparticles (NPs) were prepared using the hydrothermal approach. Read More

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http://dx.doi.org/10.3390/nano9030430DOI Listing

Thermostructural Behavior in a Series of Lanthanide-Containing Polyoxotungstate Hybrids with Copper(II) Complexes of the Tetraazamacrocycle Cyclam: A Single-Crystal-to-Single-Crystal Transformation Study.

Inorg Chem 2019 Mar 14. Epub 2019 Mar 14.

BCMaterials, Basque Center for Materials, Applications and Nanostructures , UPV/EHU Science Park , 48940 Leioa , Spain.

A series of 14 isostructural [Cu(cyclam)][{Cu(cyclam)}{(α-GeWO)Ln(HO)(OAc)}]·18HO (1-Ln, where Ln = La-Lu; cyclam = 1,4,8,11-tetraazacyclotetradecane) polyoxometalate-based hybrids reported herein represent (i) the first example of a two-dimensional covalent hybrid lattice involving the [{(α-XWO)Ln(HO)(OAc)}] archetype and (ii) the first structural characterization of such a dimeric polyoxotungste for Ln = La and Pr as well as for the combination of X = Ge and Ln = Ce, Nd, Sm, or Lu. Compounds 1-Ln have been characterized by elemental analyses, infrared spectroscopy, and thermogravimetric analysis, and their thermostructural behavior has been monitored by powder and single-crystal X-ray diffraction. The title compounds undergo two single-crystal-to-single-crystal transformations triggered by thermal dehydration leading to the [{Cu(cyclam)}{(α-GeWO)Ln(HO)(OAc)}]·4HO intermediate (2-Ln, where Ln = Eu or Er) and [Cu(cyclam)][{Cu(cyclam)}{(α-GeWO)Ln(OAc)}] (3-Ln, where Ln = Ce or Eu) final anhydrous phases, the latter evidencing a coordinatively unsaturated derivative of the dimeric archetype for the first time. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03471DOI Listing

The potential application of black and blue phosphorene as cathode materials in rechargeable aluminum batteries: a first-principles study.

Phys Chem Chem Phys 2019 Mar 14. Epub 2019 Mar 14.

State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, 100083, P. R. China.

Developing a suitable cathode material for rechargeable aluminum-ion batteries (AIBs) is currently recognized as a key challenge in pushing AIBs from lab-level to industrial application. Herein, detailed density functional theory (DFT) calculations are carried out to investigate the potential application of black and blue phosphorus monolayers as cathode materials for AIBs. It can be found that AlCl4- ions can strongly bind with both phosphorene allotropes, along with significant charge transfer. Read More

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http://dx.doi.org/10.1039/c9cp00453jDOI Listing

Art Forms in Nature: radiolaria from Haeckel and Blaschka to 3D nanotomography, quantitative image analysis, evolution, and contemporary art.

Theory Biosci 2019 Mar 13. Epub 2019 Mar 13.

Hagan Studio, 557 N 5th St, Philadelphia, PA, 19123, USA.

The illustrations of the late nineteenth-/twentieth-century scientist/artist Ernst Haeckel, as depicted in his book Art Forms in Nature (originally in German as Kunstformen der Natur, 1898-1904), have been at the intersection of art, biology, and mathematics for over a century. Haeckel's images of radiolaria (microscopic protozoans described as amoeba in glass houses) have influenced various artists for over a century (glass artists Leopold and Rudolph Blaschka; sculptor Henry Moore; architects Rene Binet, Zaha Hadid, Antoni Gaudi, Chris Bosse and Frank Gehry; and designers-filmmakers Charles and Ray Eames). We focus on this history and extend the artistic, biological, and mathematical contributions of this interdisciplinary legacy by going beyond the 3D visual, topological, and geometric analyses of radiolaria to include the nanoscale with graph theory, spatial statistics, and computational geometry. Read More

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http://dx.doi.org/10.1007/s12064-019-00289-zDOI Listing

A frame-shifted gene, which rescued its function by non-natural start codons and its application in constructing synthetic gene circuits.

J Biol Eng 2019 1;13:20. Epub 2019 Mar 1.

Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, Homi Bhabha National Institute, Block A/F, Sector-I, Bidhannagar, Kolkata, 700064 India.

Background: Frame-shifted genes results in non-functional peptides. Because of this complete loss of function, frame-shifted genes have never been used in constructing synthetic gene circuits.

Results: Here we report that the function of gene circuits is rescued by a frame-shifted gene, which functions by translating from a non-natural start codon. Read More

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http://dx.doi.org/10.1186/s13036-019-0151-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397469PMC

Site-selective and versatile aromatic C-H functionalization by thianthrenation.

Nature 2019 Mar 13;567(7747):223-228. Epub 2019 Mar 13.

Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany.

Direct C-H functionalization can quickly increase useful structural and functional molecular complexity. Site selectivity can sometimes be achieved through appropriate directing groups or substitution patterns-in the absence of such functionality, most aromatic C-H functionalization reactions provide more than one product isomer for most substrates. Development of a C-H functionalization reaction that proceeds with high positional selectivity and installs a functional group that can serve as a synthetic linchpin for further functionalization would provide access to a large variety of well-defined arene derivatives. Read More

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http://dx.doi.org/10.1038/s41586-019-0982-0DOI Listing

Mechanism of DNA translocation underlying chromatin remodelling by Snf2.

Nature 2019 Mar 13. Epub 2019 Mar 13.

MOE Key Laboratory of Protein Science, Tsinghua University, Beijing, China.

Chromatin remodellers include diverse enzymes with distinct biological functions, but nucleosome-sliding activity appears to be a common theme. Among the remodelling enzymes, Snf2 serves as the prototype to study the action of this protein family. Snf2 and related enzymes share two conserved RecA-like lobes, which by themselves are able to couple ATP hydrolysis to chromatin remodelling. Read More

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http://dx.doi.org/10.1038/s41586-019-1029-2DOI Listing

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Nature 2019 Mar 13. Epub 2019 Mar 13.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in organisms that produce serotonin (also known as 5-hydroxytryptamine (5-HT)). We demonstrate that tissue transglutaminase 2 can serotonylate histone H3 tri-methylated lysine 4 (H3K4me3)-marked nucleosomes, resulting in the presence of combinatorial H3K4me3Q5ser in vivo. Read More

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http://dx.doi.org/10.1038/s41586-019-1024-7DOI Listing

Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.

Nature 2019 Mar 13. Epub 2019 Mar 13.

Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, China.

The L-type amino acid transporter 1 (LAT1; also known as SLC7A5) catalyses the cross-membrane flux of large neutral amino acids in a sodium- and pH-independent manner. LAT1, an antiporter of the amino acid-polyamine-organocation superfamily, also catalyses the permeation of thyroid hormones, pharmaceutical drugs, and hormone precursors such as L-3,4-dihydroxyphenylalanine across membranes. Overexpression of LAT1 has been observed in a wide range of tumour cells, and it is thus a potential target for anti-cancer drugs. Read More

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http://www.nature.com/articles/s41586-019-1011-z
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http://dx.doi.org/10.1038/s41586-019-1011-zDOI Listing
March 2019
2 Reads

Experimental Configuration to Determine the Nonlinear Parameter in PMMA and CFRP with the Finite Amplitude Method.

Sensors (Basel) 2019 Mar 7;19(5). Epub 2019 Mar 7.

Department of Structural Mechanics, University of Granada, 18071 Granada, Spain.

Parameters to measure nonlinearity in polymethylmethacrylate (PMMA) and carbon fiber reinforced polymer (CFRP) materials have been determined with nonlinear ultrasound (NLUS). The nonlinear parameter β has been determined using the variation of the Finite Amplitude Method (FAM) with harmonic generation. Using this as a reference, the first contribution of this work consists of deducting the experimental configuration necessary to measure this nonlinear parameter in a correct and feasible way. Read More

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http://dx.doi.org/10.3390/s19051156DOI Listing
March 2019
3 Reads

Enhanced adsorption of nitrate from water by modified wheat straw: equilibrium, kinetic and thermodynamic studies.

Water Sci Technol 2019 Jan;79(2):302-313

Department of Water Science and Engineering, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran E-mail:

This study represents the first attempt to chemically modify wheat straw (WS) using 3-chloropropyltrimethoxysilane (CPTMS) and (1,4-diazabicyclo[2.2.2]octane) (DABCO). Read More

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http://dx.doi.org/10.2166/wst.2019.047DOI Listing
January 2019

Predicting protein-peptide interaction sites using distant protein complexes as structural templates.

Sci Rep 2019 Mar 12;9(1):4267. Epub 2019 Mar 12.

Division of Bioinformatics, Department of Physics, Chemistry and Biology, Linköping University, SE-581 83, Linköping, Sweden.

Protein-peptide interactions play an important role in major cellular processes, and are associated with several human diseases. To understand and potentially regulate these cellular function and diseases it is important to know the molecular details of the interactions. However, because of peptide flexibility and the transient nature of protein-peptide interactions, peptides are difficult to study experimentally. Read More

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http://dx.doi.org/10.1038/s41598-019-38498-7DOI Listing

Plant latex thrombin-like cysteine proteases alleviates bleeding by bypassing factor VIII in murine model.

J Cell Biochem 2019 Mar 12. Epub 2019 Mar 12.

Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, Karnataka, India.

Hemostasis is a tightly regulated process which maintains a fluid state of blood within the vasculature and provides thrombotic response upon tissue injury. Various scientific studies have implicated the role of plant latex proteases in hemostasis using in vitro experiments. However, in vivo models substantiate their role in hemostasis. Read More

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http://dx.doi.org/10.1002/jcb.28555DOI Listing

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in deletion mice.

Mol Autism 2019 28;10. Epub 2019 Feb 28.

1School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT UK.

Background: Of the many genetic mutations known to increase the risk of autism spectrum disorder, a large proportion cluster upon synaptic proteins. One such family of presynaptic proteins are the neurexins (NRXN), and recent genetic and mouse evidence has suggested a causative role for in generating altered social behaviours. Autism has been conceptualised as a disorder of atypical connectivity, yet how single-gene mutations affect such connectivity remains under-explored. Read More

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http://dx.doi.org/10.1186/s13229-019-0261-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394023PMC
February 2019

Analysis of meiotic segregation modes in biopsied blastocysts from preimplantation genetic testing cycles of reciprocal translocations.

Mol Cytogenet 2019 26;12:11. Epub 2019 Feb 26.

Reproductive Medical Center, Drum Tower Hospital Affiliated to Nanjing University Medical College, Zhongshan Road 321, Nanjing, 210008 China.

Purpose: To analyse the meiotic segregation modes of chromosomal structural rearrangements (PGT-SR) of reciprocal translocation in biopsied blastocysts from preimplantation genetic testing and to investigate whether any features of reciprocal translocation, such as carrier gender or the presence of acrocentric chromosomes or terminal breakpoints, affect meiotic segregation modes.

Methods: Comprehensive chromosomal screening was performed by next generation sequencing (NGS) on 378 biopsied blastocysts from 102 PGD cycles of 89 reciprocal translocation carriers. The segregation modes of a quadrivalent in 378 blastocysts were analysed according to the carrier's gender, chromosome type and the location of chromosome breakpoints. Read More

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https://molecularcytogenetics.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13039-019-0423-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390622PMC
February 2019
1 Read

Molecular architecture of a cylindrical self-assembly at human centrosomes.

Nat Commun 2019 Mar 11;10(1):1151. Epub 2019 Mar 11.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

The cell is constructed by higher-order structures and organelles through complex interactions among distinct structural constituents. The centrosome is a membraneless organelle composed of two microtubule-derived structures called centrioles and an amorphous mass of pericentriolar material. Super-resolution microscopic analyses in various organisms revealed that diverse pericentriolar material proteins are concentrically localized around a centriole in a highly organized manner. Read More

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http://www.nature.com/articles/s41467-019-08838-2
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http://dx.doi.org/10.1038/s41467-019-08838-2DOI Listing
March 2019
1 Read

Effect of pH on the interaction of porcine myofibrillar proteins with pyrazine compounds.

Food Chem 2019 Jul 21;287:93-99. Epub 2019 Feb 21.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou 510641, China. Electronic address:

The influence of pH-induced structural modifications of myofibrillar proteins (MPs) on their interaction mechanisms with pyrazine compounds was investigated. At a lower pH (4.9, 5. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.02.060DOI Listing

Structure⁻Activity Prediction of ACE Inhibitory/Bitter Dipeptides-A Chemometric Approach Based on Stepwise Regression.

Molecules 2019 Mar 8;24(5). Epub 2019 Mar 8.

Faculty of Food Science, Chair of Food Biochemistry, University of Warmia and Mazury in Olsztyn, Pl. Cieszyński 1, 10-726 Olsztyn-Kortowo, Poland.

Forward and backward stepwise regression (FR and BR, respectively) was applied for the structure⁻bioactivity prediction of angiotensin converting enzyme (ACE)-inhibitory/bitter-tasting dipeptides. The datasets used in this study consisted of 28 sequences and numerical variables reflecting dipeptides' physicochemical nature. The data were acquired from the BIOPEP-UWM, Biological Magnetic Resonance Databank, ProtScale, and AAindex databases. Read More

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http://dx.doi.org/10.3390/molecules24050950DOI Listing

Reliability of HF/IQA, B3LYP/IQA, and MP2/IQA data in interpreting the nature and strength of interactions.

Authors:
Ignacy Cukrowski

Phys Chem Chem Phys 2019 Mar 11. Epub 2019 Mar 11.

Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Lynnwood Road, Pretoria, 0002, South Africa.

Mainly focusing on the B3LYP level, the reliability of level of theory (LoT)-dependent IQA-defined energy terms (self- and additive atomic energies, interaction energy and its components) in interpreting interactions was investigated at three LoTs using default settings in AIMAll software explicitly implementing the actual B3LYP exchange-correlation functional. Reliability was quantified using relative errors (REs) defined as, for example, RE = B3LYP/IQA(computed) - B3LYP/IQA(expected), using reference CCSD/BBC1/IQA data to obtain the LoT/IQA(expected) terms. On average, B3LYP produced the most accurate IQA energies among the LoTs investigated, affording REs an order of magnitude smaller than those at the HF level. Read More

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http://dx.doi.org/10.1039/c9cp00243jDOI Listing
March 2019
1 Read

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy.

J Vis Exp 2019 Feb 21(144). Epub 2019 Feb 21.

School of Biomedical Sciences & the Astbury Centre for Structural Molecular Biology, University of Leeds;

Proton-pumping enzymes of electron transfer chains couple redox reactions to proton translocation across the membrane, creating a proton-motive force used for ATP production. The amphiphilic nature of membrane proteins requires particular attention to their handling, and reconstitution into the natural lipid environment is indispensable when studying membrane transport processes like proton translocation. Here, we detail a method that has been used for the investigation of the proton-pumping mechanism of membrane redox enzymes, taking cytochrome bo3 from Escherichia coli as an example. Read More

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http://dx.doi.org/10.3791/58896DOI Listing
February 2019

Importin-9 wraps around the H2A-H2B core to act as nuclear importer and histone chaperone.

Elife 2019 Mar 11;8. Epub 2019 Mar 11.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.

We report the crystal structure of nuclear import receptor Importin-9 bound to its cargo, the histones H2A-H2B. Importin-9 wraps around the core, globular region of H2A-H2B to form an extensive interface. The nature of this interface coupled with quantitative analysis of deletion mutants of H2A-H2B suggest that the NLS-like sequences in the H2A-H2B tails play a minor role in import. Read More

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http://dx.doi.org/10.7554/eLife.43630DOI Listing

α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis.

Biochim Biophys Acta Proteins Proteom 2019 Mar 7. Epub 2019 Mar 7.

Department of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai 400076, India. Electronic address:

α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical properties owing to its pathophysiological role in Parkinson's disease. Lewy bodies and Lewy neurites are the pathological hallmarks of PD and contain α-Syn aggregates as their major component. Therefore, it was hypothesized that α-Syn aggregation is actively associated with Parkinson's disease pathogenesis. Read More

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http://dx.doi.org/10.1016/j.bbapap.2019.03.001DOI Listing

Effects of ultrasonic irradiation on the synthesis, crystallization, thermal and dissolution behaviour of chloride-intercalated, co-precipitated CaFe-layered double hydroxide.

Ultrason Sonochem 2019 Feb 26. Epub 2019 Feb 26.

Department of Organic Chemistry, University of Szeged, Dóm tér 8, Szeged H-6720, Hungary; Material and Solution Structure Research Group, Institute of Chemistry, University of Szeged, Aradi Vértanúk tere 1, Szeged H-6720, Hungary. Electronic address:

The output power (30-150 W) and the periodicity (20-100%) of ultrasound emission were varied in a wide range to regulate and improve the crystallization process in the commonly used co-precipitation technique of chloride-intercalated CaFe-layered double hydroxides. The influence of ultrasound irradiation on the as-prepared materials was studied by X-ray diffractometry, dynamic light scattering, UV-Vis-NIR diffuse reflectance spectroscopy, specific surface area measurement, pore size analysis, ion-selective electrode potentiometric investigations and thermogravimetry. Additionally, structural alterations due to heat treatment at various temperatures were followed in detail by Fourier-transform infrared and X-ray absorption spectroscopies as well as scanning electron microscopy. Read More

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http://dx.doi.org/10.1016/j.ultsonch.2019.02.024DOI Listing
February 2019

Parenting in Times of War: A Meta-Analysis and Qualitative Synthesis of War Exposure, Parenting, and Child Adjustment.

Trauma Violence Abuse 2019 Mar 10:1524838019833001. Epub 2019 Mar 10.

1 University of Amsterdam, Amsterdam, the Netherlands.

This mixed methods systematic review and meta-analysis sheds more light on the role parenting practices play in children's adjustment after war exposure. Specifically, we quantitatively examined whether parenting behavior explained some of the well-known associations between war exposure and children's adjustment. In addition, we meta-synthesized qualitative evidence answering when and why parenting practices might change for war-affected families. Read More

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http://dx.doi.org/10.1177/1524838019833001DOI Listing

The evolution and adaptive development of traditional dwelling in Southern Shaanxi, China.

Environ Sci Pollut Res Int 2019 Mar 9. Epub 2019 Mar 9.

The Department of Architecture, Chang'an University, Xi'an, 701165, China.

Traditional architecture has been successful in achieving harmony between housing and environment, which is one of the most important conditions for sustainability. The research tried to study and analyze the traditional architecture to diagnose its importance and ability to solve contemporary problems. Firstly, this study sets up qualitative survey, including location, function space, and structural materials of the dwelling. Read More

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http://dx.doi.org/10.1007/s11356-019-04494-7DOI Listing

Strength of filament bundles - The role of bundle structure stochasticity.

J Mech Behav Biomed Mater 2019 Feb 21;94:1-9. Epub 2019 Feb 21.

Department of Mechanical, Aerospace and Nuclear Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, United States. Electronic address:

Most biological fibrous materials are hierarchical, in the sense that fibers of finite length assemble in bundles, which then form networks with structural role. Examples include collagen, silk, fibrin and microtubules. Some artificial fiber-based materials share this characteristic, examples including carbon nanotube (CNT) yarns and unidirectional composites. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.023DOI Listing
February 2019

Structural and energetic basis for novel epicatechin derivatives acting as GPER agonists through the MMGBSA method.

J Steroid Biochem Mol Biol 2019 Mar 6;189:176-186. Epub 2019 Mar 6.

Laboratorio de Investigación Integral Cardiometabólica, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico.

(-)-Epicatechin (Epi) has been demonstrated to activate pathways involved in GPER-stimulated nitric oxide (NO) production via endothelial NO synthase, known as the eNOS/NO pathway. Previous studies combining synthesis of four Epi derivatives demonstrated that Epi and Epi-prop, Epi-4-prop and Epi-5-prop were able to bind GPER by acting as GPER agonists, whereas docking studies allowed observation of structural details of the binding of these derivatives at the GPER binding site. However, due to the nature of past studies, the theoretical methods employed did not allow observation of structural and energetic details linked to ligand binding at the GPER binding site. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.03.006DOI Listing
March 2019
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Connectivity and free-surface effects in polymer glasses.

Sci Rep 2019 Mar 7;9(1):3830. Epub 2019 Mar 7.

Cavendish Laboratory, University of Cambridge, Cambridge, United Kingdom.

The glass transition is one of the few unsolved problems in condensed matter physics: agreement on the cause of the slowing down of structural relaxation in glass-forming liquids is lacking. Glasses are amorphous solids, which do not possess the long-range crystalline order, yet display arrested dynamics and the shear elastic modulus characteristic of equilibrium elasticity. It has been suggested that due to the influence of intramolecular interactions and chain connectivity, the nature of the glass transition in polymers and in standard glass-formers is fundamentally different. Read More

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http://dx.doi.org/10.1038/s41598-019-40286-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405857PMC

Mosquito cells persistently infected with dengue virus produce viral particles with host-dependent replication.

Virology 2019 Feb 27;531:1-18. Epub 2019 Feb 27.

Maestría en Ciencias en Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico; Doctorado en Ciencias en Biotecnología, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico. Electronic address:

Dengue viruses (DENV) are important arboviruses that can establish a persistent infection in its mosquito vector Aedes. Mosquitoes have a short lifetime in nature which makes trying to study the processes that take place during persistent viral infections in vivo. Therefore, C6/36 cells have been used to study this type of infection. Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.018DOI Listing
February 2019

Structural characterization and antioxidant potential of a novel anionic exopolysaccharide produced by marine Microbacterium aurantiacum FSW-25.

Int J Biol Macromol 2019 Mar 4. Epub 2019 Mar 4.

Biochemical Engineering Research & Process Development Centre (BERPDC), Institute of Microbial Technology (IMTECH), Council of Scientific and Industrial Research (CSIR), Sector 39A, Chandigarh 160036, India. Electronic address:

An exopolysaccharide (EPS) producing strain FSW-25 was isolated from the Rasthakaadu beach Kanyakumari, Tamil Nadu India. Based on polyphasic taxonomy, the strain FSW-25 was assigned to the genus Microbacterium and found to be the closest relative of the species aurantiacum. Large quantity of EPS (7. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.016DOI Listing
March 2019
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Differences in binding kinetics, bond strength and adduct formation between Pt-based drugs and S- or N-donor groups: A comparative study using mass spectrometry techniques.

Eur J Pharm Sci 2019 Mar 4;132:96-105. Epub 2019 Mar 4.

Analytical Chemistry Department, Faculty of Chemistry, Complutense University of Madrid, Avenida Complutense s/n, 28040 Madrid, Spain. Electronic address:

Pt-S and Pt-N interactions resulting from the coordination of cisplatin, oxaliplatin and carboplatin to two synthetic peptides that differ from each other in one amino acid (Met or His) have been thoroughly studied in this work. The degree of Pt-binding was determined by inductively coupled plasma mass spectrometry after the separation of the Pt-complexes from the unreacted drugs by size exclusion chromatography. Cisplatin and oxaliplatin showed high affinity for the peptides from the first hours of incubation, although the peptides required longer incubation times to obtain the same platination degrees with cisplatin than with oxaliplatin. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.03.002DOI Listing

The First 2D Homochiral Lead Iodide Perovskite Ferroelectrics: [R- and S-1-(4-Chlorophenyl)ethylammonium] PbI.

Adv Mater 2019 Mar 6:e1808088. Epub 2019 Mar 6.

Ordered Matter Science Research Center, Nanchang University, Nanchang, 330031, P. R. China.

2D organic-inorganic lead iodide perovskites have recently received tremendous attention as promising light absorbers for solar cells, due to their excellent optoelectronic properties, structural tunability, and environmental stability. However, although great efforts have been made, no 2D lead iodide perovskites have been discovered as ferroelectrics, in which the ferroelectricity may improve the photovoltaic performance. Here, by incorporating homochiral cations, 2D lead iodide perovskite ferroelectrics [R-1-(4-chlorophenyl)ethylammonium] PbI and [S-1-(4-chlorophenyl)ethylammonium] PbI are successfully obtained. Read More

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http://dx.doi.org/10.1002/adma.201808088DOI Listing
March 2019
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Synthesis of 2D and 3D MOFs with tuneable Lewis acidity from preformed 1D hybrid sub-domains.

Chem Sci 2019 Feb 17;10(7):2053-2066. Epub 2018 Dec 17.

Instituto de Tecnología Química , Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas , Avenida de los Naranjos s/n , E-46022 Valencia , Spain . Email: ; Email: ; Tel: +34963877800.

Novel MOF-type materials with different morphologies based on assembled 1D organic-inorganic sub-domains were prepared using specific monodentate benzylcarboxylate spacers with functional substituents in the para-position as structure modulating agents. The combination of electron-withdrawing or electron-donating functions in the organic spacers with suitable solvothermal synthesis conditions allowed modulating the structuration level (2D or 3D), vacancies, physico-chemical properties and Lewis acidity strength of the metal-organic structures. Furthermore, bimetallic (Al/Fe) MOF-type materials were synthesized by a one-pot direct process without modification of the structural framework. Read More

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http://xlink.rsc.org/?DOI=C8SC04372H
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http://dx.doi.org/10.1039/c8sc04372hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375358PMC
February 2019
1 Read

Structural basis of STING binding with and phosphorylation by TBK1.

Nature 2019 Mar 6. Epub 2019 Mar 6.

Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

The invasion of mammalian cytoplasm by microbial DNA from infectious pathogens or by self DNA from the nucleus or mitochondria represents a danger signal that alerts the host immune system. Cyclic GMP-AMP synthase (cGAS) is a sensor of cytoplasmic DNA that activates the type-I interferon pathway. On binding to DNA, cGAS is activated to catalyse the synthesis of cyclic GMP-AMP (cGAMP) from GTP and ATP. Read More

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http://www.nature.com/articles/s41586-019-1000-2
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http://dx.doi.org/10.1038/s41586-019-1000-2DOI Listing
March 2019
3 Reads

Insights into the dynamic nature of the dsRNA-bound TLR3 complex.

Sci Rep 2019 Mar 6;9(1):3652. Epub 2019 Mar 6.

Department of Animal Biotechnology, Chonbuk National University, Jeonju, 54896, Republic of Korea.

Toll-like receptor 3 (TLR3), an endosomal receptor crucial for immune responses upon viral invasion. The TLR3 ectodomain (ECD) is responsible for double-stranded RNA (dsRNA) recognition and mutational analysis suggested that TLR3 ECD C-terminal dimerization is essential for dsRNA binding. Moreover, the L412F polymorphism of TLR3 is associated with human diseases. Read More

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http://www.nature.com/articles/s41598-019-39984-8
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http://dx.doi.org/10.1038/s41598-019-39984-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403236PMC
March 2019
2 Reads

Induced high-temperature ferromagnetism by structural phase transitions in strained antiferromagnetic γ-FeMn epitaxial films.

Sci Rep 2019 Mar 6;9(1):3669. Epub 2019 Mar 6.

Department of Physics and Energy Harvest-Storage Research Center (EHSRC), University of Ulsan, Ulsan, 44610, Republic of Korea.

Strain effects in epitaxial films can substantially enhance individual functional properties or induce properties which do not exist in corresponding bulk materials. The bcc α-FeMn films are a ferromagnetic with a Curie temperature between 650 K and 750 K, which do not exist in nature can be manipulated through the tensile strain. In this study, γ-FeMn epitaxial films grown on GaAs(001) using molecular beam epitaxy are found to structural transition from the face-centered-cubic (fcc, a = 0. Read More

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http://dx.doi.org/10.1038/s41598-019-39949-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403386PMC
March 2019
1 Read

Anterior abdominal wall defects managed at a tertiary maternal-fetal medicine service in New Zealand: What counselling advice can we offer parents?

Aust N Z J Obstet Gynaecol 2019 Mar 6. Epub 2019 Mar 6.

Maternal Fetal Medicine, School of Medicine, University of Auckland, Auckland, New Zealand.

Background: Anterior abdominal wall defects, including gastroschisis and omphalocoele, are common fetal anomalies. The management remains complicated, and their diagnosis may lead to significant parental distress. Effective parental counselling may impact on parental perceptions of the defect and help guide pregnancy management. Read More

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http://doi.wiley.com/10.1111/ajo.12965
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http://dx.doi.org/10.1111/ajo.12965DOI Listing
March 2019
6 Reads

Structural and Functional Characterization of a Novel Acidophilic 7α-Hydroxysteroid Dehydrogenase.

Protein Sci 2019 Mar 6. Epub 2019 Mar 6.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, PR China.

7α-Hydroxysteroid dehydrogenase (7α-HSDH) is an NAD(P)H-dependent oxidoreductase belonging to the short-chain dehydrogenases/reductases. In vitro, 7α-HSDH is involved in the efficient biotransformation of taurochenodeoxycholic acid (TCDCA) to tauroursodeoxycholic acid (TUDCA). In this study, a gene encoding a novel 7α-HSDH (named as St-2-1) from fecal samples of black bear was cloned and heterologously expressed in Escherichia coli. Read More

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http://dx.doi.org/10.1002/pro.3599DOI Listing

Covalent Fluorophore Labeling of Oligonucleotides and Generation of Other Oligonucleotide Bioconjugates.

Methods Mol Biol 2019 ;1943:61-72

Department of Pharmaceutical Chemistry, University of Vienna, Vienna, Austria.

Oligonucleotide conjugates have already reached considerable importance in life science research and oligonucleotide drug development. Since the preparation of oligonucleotide conjugates depends critically on the chemical nature of the used ligand and linker, there is no general and universal procedure. Here, we present a detailed, quick, and facile protocol for attaching fluorescent dyes or cross-linkers of variable chemical stability to oligonucleotides at 3'- or 5'-aminoalkyl handles. Read More

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http://dx.doi.org/10.1007/978-1-4939-9092-4_4DOI Listing
January 2019

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy.

Hum Reprod 2019 Mar 6. Epub 2019 Mar 6.

Ghent-Fertility And Stem cell Team (G-FAST), Department for Reproductive Medicine, Ghent University Hospital, Corneel Heymanslaan 10, Ghent, Belgium.

Study Question: What is the accuracy of preimplantation genetic testing for aneuploidies (PGT-A) when considering human peri-implantation outcomes in vitro?

Study Answer: The probability of accurately diagnosing an embryo as abnormal was 100%, while the proportion of euploid embryos classified as clinically suitable was 61.9%, yet if structural and mosaic abnormalities were not considered accuracy increased to 100%, with a 0% false positive and false negative rate.

What Is Already Known: Embryo aneuploidy is associated with implantation failure and early pregnancy loss. Read More

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http://dx.doi.org/10.1093/humrep/dez012DOI Listing
March 2019
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Distinct signature of local tetrahedral ordering in the scattering function of covalent liquids and glasses.

Sci Adv 2019 Mar 1;5(3):eaav3194. Epub 2019 Mar 1.

Department of Fundamental Engineering, Institute of Industrial Science, University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.

Tetrahedral amorphous materials such as SiO, GeO, Si, Ge, C, and chalcogenides are extremely important in nature and technology. It is known that covalent bonding favors local tetrahedral order in these materials. However, how to extract information on this structural order from the scattering function has remained elusive. Read More

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http://dx.doi.org/10.1126/sciadv.aav3194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397023PMC