757 results match your criteria Nature clinical practice. Cardiovascular medicine[Journal]


Concurrent upregulation of endogenous proapoptotic and antiapoptotic factors in failing human hearts.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):250-61

University of California Irvine School of Medicine, Irvine, CA, USA.

Background: Despite widespread activation of proapoptotic stimuli and mediators, the degree of apoptosis in failing hearts is not very high. Endogenous antiapoptotic mechanisms are thought to be triggered by the heart-failure process. We investigated whether activation of endogenous apoptosis inhibitors plays a part when death receptor and mitochondrial apoptotic pathways have been triggered. Read More

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http://dx.doi.org/10.1038/ncpcardio1452DOI Listing
March 2009
5 Reads

Use of arginine-glycine-aspartic acid adhesion peptides coupled with a new collagen scaffold to engineer a myocardium-like tissue graft.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):240-9

Biosurgical Research Laboratory, Georges Pompidou European Hospital, Paris V University, Paris, France.

Background: Cardiac tissue engineering might be useful in treatment of diseased myocardium or cardiac malformations. The creation of functional, biocompatible contractile tissues, however, remains challenging. We hypothesized that coupling of arginine-glycine-aspartic acid-serine (RGD+) adhesion peptides would improve cardiomyocyte viability and differentiation and contractile performance of collagen-cell scaffolds. Read More

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http://dx.doi.org/10.1038/ncpcardio1451DOI Listing
March 2009
3 Reads

Longitudinal cohort study on the effectiveness of lipid apheresis treatment to reduce high lipoprotein(a) levels and prevent major adverse coronary events.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):229-39

Labor Dr Stein und Kollegen, Medizinisches Versorgungszentrum Laboratoriumsmedizin, Mikrobiologie, Infektionsepidemiologie, Virologie, Transfusionsmedizin und Humangenetik, Mönchengladbach, Germany.

Background: We investigated in a longitudinal, multicenter, cohort study whether combined lipid apheresis and lipid-lowering medication can reduce extremely high levels of lipoprotein(a) (Lp[a]) and thus prevent major adverse coronary events (MACE) more efficaciously than lipid-lowering medication alone.

Methods: Eligible patients had coronary artery disease and Lp(a) levels > or =2.14 micromol/l (95th percentile). Read More

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http://dx.doi.org/10.1038/ncpcardio1456DOI Listing
March 2009
9 Reads

Noninvasive imaging of atheromatous carotid plaques.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):200-9

Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Atherothrombosis is a systemic disease of the arterial wall that affects the carotid, coronary, and peripheral vascular beds, and the aorta. This condition is associated with complications such as stroke, myocardial infarction, and peripheral vascular disease, which usually result from unstable atheromatous plaques. The study of atheromatous plaques can provide useful information about the natural history and progression of the disease, and aid in the selection of appropriate treatment. Read More

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http://dx.doi.org/10.1038/ncpcardio1455DOI Listing
March 2009
3 Reads

The role of interleukin 18 in the pathogenesis of hypertension-induced vascular disease.

Authors:
Simon W Rabkin

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):192-9

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Understanding the mechanism by which chronic high blood pressure induces vascular disease is of fundamental importance for prevention of the adverse consequences of hypertension. Clinical and population studies have consistently found increased circulating levels of interleukin 18 (IL-18) in patients with hypertension. Although obesity, and possibly age, is a determinant of plasma IL-18 levels, the relationship of IL-18 to hypertension seems to be independent of these factors. Read More

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http://dx.doi.org/10.1038/ncpcardio1453DOI Listing
March 2009
3 Reads

Diagnosis and management of atherosclerotic renal artery stenosis: improving patient selection and outcomes.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):176-90

Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA 70121, USA.

Renal artery stenosis (RAS) is common among patients with atherosclerosis, and is found in 20-30% of individuals who undergo diagnostic cardiac catheterization. Renal artery duplex ultrasonography is the diagnostic procedure of choice for screening outpatients for RAS. Percutaneous renal artery stent placement is the preferred method of revascularization for hemodynamically significant RAS, and is favored over balloon angioplasty alone. Read More

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http://www.isdbweb.org/documents/file/1576_1.pdf
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http://www.nature.com/doifinder/10.1038/ncpcardio1448
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http://dx.doi.org/10.1038/ncpcardio1448DOI Listing
March 2009
6 Reads

How important are health systems in the prevention of cardiovascular and other noncommunicable diseases?

Authors:
Sania Nishtar

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):170-1

Heartfile, Chak Shahzad, Islamabad, Pakistan.

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http://dx.doi.org/10.1038/ncpcardio1445DOI Listing
March 2009
2 Reads

JUPITER strikes earth.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):159

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http://dx.doi.org/10.1038/ncpcardio1454DOI Listing
March 2009
4 Reads

Coronary venous pressure elevation 'risks and benefit'.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):E4

Department of Cardiothoracic Surgery, Medical University Vienna, Waehringerguertel 18-20, Vienna, 1090, Austria.

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http://dx.doi.org/10.1038/ncpcardio1476DOI Listing
March 2009
8 Reads

Mild increase in coronary sinus pressure with coronary sinus reducer stent for treatment of refractory angina.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):E3

Department of Cardiothoracic Surgery, Hadassah University Hospital, 51 Borochov St, Givataim 53222, Jerusalem, Israel.

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http://dx.doi.org/10.1038/ncpcardio1475DOI Listing
March 2009
4 Reads

C-reactive protein and severity of coronary allograft vasculopathy.

Nat Clin Pract Cardiovasc Med 2009 Mar;6(3):E1; discussion E2

Methodist Research Institute, Clarian Health, 1800 N. Capitol Avenue, Suite E504J, Indianapolis IN 46202, USA.

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http://dx.doi.org/10.1038/ncpcardio1473DOI Listing
March 2009
5 Reads

Emergency surgical treatment of advanced endomyocardial fibrosis in Mozambique.

Nat Clin Pract Cardiovasc Med 2009 Mar 3;6(3):210-4. Epub 2009 Feb 3.

Maputo Heart Institute, Mozambique.

Background: An 11-year-old girl presented to a specialist cardiac facility in Mozambique. She had severe heart failure and massive cardiac enlargement, herniation of the heart into the epigastrium, atrial fibrillation, signs of severe pulmonary hypertension and a low cardiac output.

Investigations: Chest radiography, echocardiography, 24 h Holter monitoring, and cardiac catheterization. Read More

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http://dx.doi.org/10.1038/ncpcardio1449DOI Listing
March 2009
3 Reads

Prospective, observational study of antiplatelet and coagulation biomarkers as predictors of thromboembolic events after implantation of ventricular assist devices.

Nat Clin Pract Cardiovasc Med 2009 Feb;6(2):147-57

Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Long-term success in ventricular assist device (VAD) recipients is limited by thromboembolic events, the prediction of which remains elusive. We evaluated the predictive value of aspirin hyporesponsiveness and markers of coagulation and fibrinolysis.

Methods: We prospectively enrolled patients scheduled to undergo VAD implantation between June 2004 and March 2006. Read More

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http://dx.doi.org/10.1038/ncpcardio1441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794654PMC
February 2009
5 Reads

Prime time for a polypill after myocardial infarction?

Authors:
Valentin Fuster

Nat Clin Pract Cardiovasc Med 2009 Feb;6(2):83

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http://dx.doi.org/10.1038/ncpcardio1443DOI Listing
February 2009
3 Reads

Cross-sectional, prospective study of MRI reproducibility in the assessment of plaque burden of the carotid arteries and aorta.

Nat Clin Pract Cardiovasc Med 2009 Mar 27;6(3):219-28. Epub 2009 Jan 27.

Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.

Background: The reliability of imaging techniques to assess early atherosclerosis remains unclear. We did a cross-sectional, prospective study to test reproducibility of MRI when imaging arteries, to assess risk of cardiovascular disease and correlations with age and sex.

Methods: Between January 2003 and December 2006 we performed black-blood MRI of both common carotid arteries and the thoracic descending aorta in patients with cardiovascular risk factors who were referred from clinics in New York, NY, USA. Read More

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http://dx.doi.org/10.1038/ncpcardio1444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338149PMC
March 2009
9 Reads

Primary prevention of cardiovascular events in diabetes: is there a role for aspirin?

Nat Clin Pract Cardiovasc Med 2009 Mar 20;6(3):168-9. Epub 2009 Jan 20.

University of Oxford Diabetes Trials Unit, Oxford, UK.

The POPADAD (Prevention Of Progression of Arterial Disease And Diabetes) study did not show a benefit for low-dose aspirin therapy or administration of antioxidants for the primary prevention of cardiovascular disease events in individuals with diabetes and asymptomatic peripheral arterial disease. Although low-dose aspirin continues to be recommended in international guidelines, no convincing trial-based evidence exists that supports its routine use for primary prevention of cardiovascular disease in people with diabetes. This paradox is unhelpful and the guidelines should be relaxed until definitive evidence becomes available. Read More

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http://dx.doi.org/10.1038/ncpcardio1446DOI Listing
March 2009
3 Reads

Is intravenous recombinant plasminogen activator effective up to 4.5 h after onset of ischemic stroke?

Authors:
Peter M Rothwell

Nat Clin Pract Cardiovasc Med 2009 Mar 20;6(3):164-5. Epub 2009 Jan 20.

University Department of Clinical Neurology, John Radcliffe Hospital, Headington, Oxford, UK.

Randomized, controlled trials and subsequent observational studies in routine clinical practice have shown that intravenous recombinant tissue plasminogen activator is safe and effective when used in selected patients within 3h of the onset of acute ischemic stroke. Results of the ECASS III (European Cooperative Acute Stroke Study III) trial have now confirmed the finding of a previous meta-analysis of data from individual patients from smaller trials, which showed that the time-window for benefit actually extends to 4.5h. Read More

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http://dx.doi.org/10.1038/ncpcardio1447DOI Listing
March 2009
2 Reads

The Marfan aortic root: time to refine surgical guidelines.

Authors:
Stephen Westaby

Nat Clin Pract Cardiovasc Med 2009 Mar 13;6(3):172-5. Epub 2009 Jan 13.

University of Wales, Swansea, UK.

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http://dx.doi.org/10.1038/ncpcardio1365DOI Listing
March 2009
7 Reads

Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis.

Nat Clin Pract Cardiovasc Med 2009 Mar 13;6(3):215-8. Epub 2009 Jan 13.

Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.

Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG.

Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. Read More

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http://www.nature.com/articles/ncpcardio1436
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http://dx.doi.org/10.1038/ncpcardio1436DOI Listing
March 2009
7 Reads

The emerging role of cardiovascular magnetic resonance in refining the diagnosis of hypertrophic cardiomyopathy.

Nat Clin Pract Cardiovasc Med 2009 Mar 13;6(3):166-7. Epub 2009 Jan 13.

Department of Cardiology, The Heart Hospital, University College London Hospitals, NHS Foundation Trust, London, UK.

Hypertrophic cardiomyopathy (HCM) is a genetically and phenotypically diverse disease with some patients at risk of sudden death or heart failure. Maron et al. used cardiovascular magnetic resonance, in a specialist clinic setting, to identify a cohort of HCM patients with left ventricular apical aneurysms that were not detected by conventional echocardiography. Read More

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http://dx.doi.org/10.1038/ncpcardio1442DOI Listing
March 2009
2 Reads

Fixed-dose combination therapy and secondary cardiovascular prevention: rationale, selection of drugs and target population.

Nat Clin Pract Cardiovasc Med 2009 Feb 23;6(2):101-10. Epub 2008 Dec 23.

Department of Translational Research, CNIC, Madrid, Spain.

Ischemic heart disease and stroke are the leading causes of death worldwide. A large proportion of individuals at high 10-year risk of a cardiovascular event live in low-income and middle-income countries, and the large majority of all cardiovascular events occur in developing countries. A large amount of evidence supports the use of pharmacological treatment for the prevention of cardiovascular death in this population, including antiplatelet drugs, beta blockers, lipid-lowering agents and angiotensin-converting-enzyme inhibitors. Read More

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http://www.nature.com/articles/ncpcardio1419
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http://dx.doi.org/10.1038/ncpcardio1419DOI Listing
February 2009
9 Reads

Issues to consider in the pharmaceutical development of a cardiovascular polypill.

Nat Clin Pract Cardiovasc Med 2009 Feb 23;6(2):112-9. Epub 2008 Dec 23.

Center of Investigation and Pharmaceutical Development, Grupo Ferrer Internacional, Barcelona, Spain.

The pharmaceutical development of a cardiovascular polypill presents several unique challenges. The selection of the type and number of active drugs to be incorporated requires important consideration of clinical, pharmaceutical and commercial issues, and the final decision with regard to the polypill's components depends on how these issues are prioritized. Once the drug combination has been chosen, developers must determine which pharmaceutical formulation should be used. Read More

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http://dx.doi.org/10.1038/ncpcardio1424DOI Listing
February 2009
5 Reads

Cardiac manifestations of HIV infection: an African perspective.

Nat Clin Pract Cardiovasc Med 2009 Feb 23;6(2):120-7. Epub 2008 Dec 23.

Division of Cardiology at Groote Schuur Hospital, Cape Town, South Africa.

The pericardium, myocardium, coronary arteries and pulmonary arteries are the main targets for cardiac disease in people who are infected with HIV. Geography and access to highly active anti-retroviral therapy (HAART) have a major influence on which of these targets is affected. In sub-Saharan Africa, where tuberculosis is endemic and access to HAART is limited, the dominant forms of HIV-associated heart disease are pericardial tuberculosis and cardiomyopathy. Read More

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http://dx.doi.org/10.1038/ncpcardio1437DOI Listing
February 2009
4 Reads

The need to test the theories behind the Polypill: rationale behind the Indian Polycap Study.

Nat Clin Pract Cardiovasc Med 2009 Feb 23;6(2):96-7. Epub 2008 Dec 23.

Department of Pharmacology, St John's Medical College, Bangalore, India.

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http://dx.doi.org/10.1038/ncpcardio1438DOI Listing
February 2009
5 Reads

A case of coronary artery fistula visualized by 64-slice multidetector CT.

Nat Clin Pract Cardiovasc Med 2009 Jan;6(1):57-60

University of Rome Tor Vergata, Rome, Italy.

Background: A 27-year-old woman was admitted to hospital with a 1-year history of mild dyspnea.

Investigations: Physical examination, chest radiography, electrocardiography, transthoracic echocardiography, 64-slice multidetector CT and coronary angiography.

Diagnosis: Fistula originating from the left anterior coronary artery and draining into the right ventricle, in conjunction with an aneurysm of the left anterior descending artery. Read More

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http://dx.doi.org/10.1038/ncpcardio1413DOI Listing
January 2009
6 Reads

Diabetes and aspirin: beware of underpowered negative trials.

Nat Clin Pract Cardiovasc Med 2009 Jan;6(1)

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http://dx.doi.org/10.1038/ncpcardio1433DOI Listing
January 2009
4 Reads

Tunneled left anterior descending artery in a child with hypertrophic cardiomyopathy.

Nat Clin Pract Cardiovasc Med 2009 Feb 17;6(2):134-9. Epub 2008 Dec 17.

Referral Center for Cardiomyopathies, Cardiology Department, Careggi University Hospital, Florence, Italy.

Background: A 10-year-old boy presented with a history of severe angina on exertion. A two-dimensional echocardiogram showed mild asymmetric left ventricular (LV) hypertrophy localized to the interventricular septum, consistent with nonobstructive hypertrophic cardiomyopathy. A maximal treadmill exercise test was terminated early owing to marked downsloping of the ST-T segment on all precordial leads, associated with mild chest discomfort. Read More

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http://dx.doi.org/10.1038/ncpcardio1420DOI Listing
February 2009
5 Reads

Cardiac amyloidosis, a monoclonal gammopathy and a potentially misleading mutation.

Nat Clin Pract Cardiovasc Med 2009 Feb 17;6(2):128-33. Epub 2008 Dec 17.

National Amyloidosis Centre, Centre for Amyloidosis & Acute Phase Proteins, Department of Medicine (Hampstead Campus), Royal Free and University College Medical School, London, UK.

Background: A 46-year-old Afro-Caribbean man presented with progressive dyspnea and recurrent syncope. Clinical examination revealed evidence of biventricular failure.

Investigations: Electrocardiography, echocardiography, cardiac biopsy, measurement of serum levels of free light chain, scintigraphy with radiolabeled serum amyloid P component, transthyretin gene sequencing and immunohistochemistry. Read More

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http://dx.doi.org/10.1038/ncpcardio1423DOI Listing
February 2009
4 Reads

Triglycerides and cardiovascular events in ACS: the need for combined lipid-altering therapies.

Nat Clin Pract Cardiovasc Med 2009 Feb 17;6(2):98-100. Epub 2008 Dec 17.

Department of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI 48109-5853, USA.

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http://dx.doi.org/10.1038/ncpcardio1435DOI Listing
February 2009
2 Reads

Observational study of mortality risk stratification by ischemic presentation in patients with acute type A aortic dissection: the Penn classification.

Nat Clin Pract Cardiovasc Med 2009 Feb 9;6(2):140-6. Epub 2008 Dec 9.

Department of Anesthesiology and Critical Care, Cardiothoracic and Vascular Section, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

Background: Acute type A aortic dissection is a surgical emergency, with an operative mortality as high as 25%. Ischemia is a known predictor of mortality. We tested the efficacy of a classification system--the Penn classification, which is based on ischemic pattern at clinical presentation--to stratify operative mortality risk and identify high-risk groups of patients for further intervention and study. Read More

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http://dx.doi.org/10.1038/ncpcardio1417DOI Listing
February 2009
11 Reads

Obstructive sleep apnea and risk of stroke: time for a trial.

Nat Clin Pract Cardiovasc Med 2009 Feb 9;6(2):90-1. Epub 2008 Dec 9.

Division of CardiovascularDiseases, Mayo Clinic, Rochester, MN 55905, USA.

Obstructive sleep apnea (OSA) is common among patients with cardiovascular disease; however, the association between OSA and risk of cardiovascular events is not clear. Valham and colleagues studied the effect of OSA on incident stroke, acute myocardial infarction, and death in patients with angina pectoris who were referred for coronary angiography. Patients with OSA were not more likely to die or experience a myocardial infarction than were individuals without OSA, but, after adjusting for potential confounders, patients with OSA were approximately three times more likely to experience a new stroke. Read More

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http://dx.doi.org/10.1038/ncpcardio1418DOI Listing
February 2009
3 Reads

Impact of optimal medical therapy and percutaneous coronary intervention on patients with stable angina.

Nat Clin Pract Cardiovasc Med 2009 Feb 9;6(2):92-3. Epub 2008 Dec 9.

Interventional Cardiology Unit, San Raffaele Scientific Institute, Milan, Italy.

Percutaneous coronary intervention (PCI) is not associated with reduction in risk of death or myocardial infarction in patients who have chronic stable angina with normal left ventricular function and moderate coronary artery disease. A substudy of the COURAGE trial has shown that both PCI plus optimal medical therapy (OMT) and OMT alone result in marked improvements in quality of life and angina, but that PCI can substantially benefit patients with more-severe and more-frequent angina. A number of caveats to this study exist, including the extent to which the findings can be applied to the general patient population and the large proportion of patients who had mild angina or were asymptomatic--it is difficult to make these patients feel better. Read More

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http://dx.doi.org/10.1038/ncpcardio1422DOI Listing
February 2009
5 Reads

Multicenter assessment of coronary allograft vasculopathy by intravascular ultrasound-derived analysis of plaque composition.

Nat Clin Pract Cardiovasc Med 2009 Jan 2;6(1):61-9. Epub 2008 Dec 2.

Cardiovascular Center, OLV Hospital, Aalst, Belgium.

Background: Coronary allograft vasculopathy is a severe complication of heart transplantation. We used virtual histology intravascular ultrasound to characterize plaque burden and tissue composition over time in heart transplant recipients.

Methods: We recruited patients undergoing heart transplantation in four centers in Europe and the US between 2004 and 2006. Read More

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http://dx.doi.org/10.1038/ncpcardio1410DOI Listing
January 2009
3 Reads

A case of giant thoracic aortic aneurysm that initially presented as an altered mental state.

Nat Clin Pract Cardiovasc Med 2009 Jan 2;6(1):82. Epub 2008 Dec 2.

Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1038/ncpcardio1412DOI Listing
January 2009
3 Reads

Pathophysiology of concomitant atrial fibrillation and heart failure: implications for management.

Nat Clin Pract Cardiovasc Med 2009 Jan 2;6(1):46-56. Epub 2008 Dec 2.

Mayo Clinic, Rochester, MN, USA.

Atrial fibrillation (AF) and heart failure (HF) are two conditions regularly encountered in clinical practice. They share many common risk factors, and are often seen concurrently in an individual patient. Global aging of the population is likely to lead to an increase in the prevalence of both AF and HF alone, as well as in their combined state. Read More

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http://dx.doi.org/10.1038/ncpcardio1414DOI Listing
January 2009
3 Reads

Do microRNAs regulate myocardial fibrosis?

Authors:
Javier Díez

Nat Clin Pract Cardiovasc Med 2009 Feb 2;6(2):88-9. Epub 2008 Dec 2.

Division of Cardiovascular Sciences, Center of Applied Medical Research, University Clinic, University of Navarra, Pamplona, Spain.

Fibrosis is an established morphological feature of the structural myocardial remodeling that occurs in several cardiac diseases. This feature confers an increased risk for adverse cardiovascular events such as ventricular dysfunction and arrhythmias. The molecular mechanisms that lead to a fibrogenic cardiac phenotype are still being elucidated. Read More

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http://dx.doi.org/10.1038/ncpcardio1415DOI Listing
February 2009
3 Reads

Reflections on the regulation of the Polypill.

Authors:
Lennart Forslund

Nat Clin Pract Cardiovasc Med 2009 Feb 2;6(2):94-5. Epub 2008 Dec 2.

Medical Information Unit, Medical Products Agency, Uppsala, Sweden.

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http://dx.doi.org/10.1038/ncpcardio1416DOI Listing
February 2009
4 Reads

Variations in DSG2: V56M, V158G and V920G are not pathogenic for arrhythmogenic right ventricular dysplasia/cardiomyopathy.

Nat Clin Pract Cardiovasc Med 2008 Dec;5(12):E1

ECRC/Charite Campus Buch, Lindenberger Weg 80, 13125 Berlin, Germany.

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http://dx.doi.org/10.1038/ncpcardio1434DOI Listing
December 2008
6 Reads

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology.

Authors:
Peter F Davies

Nat Clin Pract Cardiovasc Med 2009 Jan 25;6(1):16-26. Epub 2008 Nov 25.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Institute for Medicine and Engineering, 1010 Vagelos Laboratories, 3340 Smith Walk, Philadelphia, PA 19104, USA.

Endothelium lining the cardiovascular system is highly sensitive to hemodynamic shear stresses that act at the vessel luminal surface in the direction of blood flow. Physiological variations of shear stress regulate acute changes in vascular diameter and when sustained induce slow, adaptive, structural-wall remodeling. Both processes are endothelium-dependent and are systemically and regionally compromised by hyperlipidemia, hypertension, diabetes and inflammatory disorders. Read More

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http://dx.doi.org/10.1038/ncpcardio1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851404PMC
January 2009
5 Reads

Protective vascular and myocardial effects of adiponectin.

Nat Clin Pract Cardiovasc Med 2009 Jan 25;6(1):27-35. Epub 2008 Nov 25.

Harvard Medical School and the Joslin Diabetes Center in Boston, USA.

Adiponectin is an abundant plasma protein secreted from adipocytes that elicits protective effects in the vasculature and myocardium. In obesity and insulin-resistant states, adiponectin levels are reduced and loss of its protective effects might contribute to the excess cardiovascular risk observed in these conditions. Adiponectin ameliorates the progression of macrovascular disease in rodent models, consistent with its correlation with improved vascular outcomes in epidemiological studies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658652PMC
http://dx.doi.org/10.1038/ncpcardio1398DOI Listing
January 2009
6 Reads

Adverse cardiovascular effects of air pollution.

Nat Clin Pract Cardiovasc Med 2009 Jan 25;6(1):36-44. Epub 2008 Nov 25.

Centre for Cardiovascular Science, University of Edinburgh, UK.

Air pollution is increasingly recognized as an important and modifiable determinant of cardiovascular disease in urban communities. Acute exposure has been linked to a range of adverse cardiovascular events including hospital admissions with angina, myocardial infarction, and heart failure. Long-term exposure increases an individual's lifetime risk of death from coronary heart disease. Read More

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http://dx.doi.org/10.1038/ncpcardio1399DOI Listing
January 2009
12 Reads

Cardiac cell and gene therapies: two trajectories, one goal.

Nat Clin Pract Cardiovasc Med 2008 Dec;5(12):749

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http://dx.doi.org/10.1038/ncpcardio1411DOI Listing
December 2008
4 Reads

Hypertrophic obstructive cardiomyopathy and sleep-disordered breathing: an unfavorable combination.

Nat Clin Pract Cardiovasc Med 2009 Jan 18;6(1):14-5. Epub 2008 Nov 18.

Cardiovascular Division, Mayo Clinic, Scottsdale, AZ 85259, USA.

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http://dx.doi.org/10.1038/ncpcardio1401DOI Listing
January 2009
6 Reads

Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study.

Nat Clin Pract Cardiovasc Med 2009 Jan 11;6(1):70-81. Epub 2008 Nov 11.

Department of Cardiology, Medical University of Vienna, Austria.

Background: Combined intracoronary and intramyocardial administration might improve outcomes for bone-marrow-derived stem cell therapy for acute myocardial infarction (AMI). We compared the safety and feasibility of early and late delivery of stem cells with combined therapy approaches.

Methods: Patients with left ventricular ejection fraction less than 45% after AMI were randomly assigned stem cell delivery via intramyocardial injection and intracoronary infusion 3-6 weeks or 3-4 months after AMI. Read More

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http://dx.doi.org/10.1038/ncpcardio1388DOI Listing
January 2009
15 Reads

Circulating white blood cells and platelets amplify oxidative stress in heart failure.

Nat Clin Pract Cardiovasc Med 2008 Dec 28;5(12):811-20. Epub 2008 Oct 28.

Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.

Background: Mitochondria of circulating white blood cells (WBC) and platelets sense oxidative stress during capillary passage and react by producing reactive oxygen species (ROS). Although evidence indicates that congestive heart failure (CHF) is associated with oxidative stress, the role of WBC and platelets as mediators in CHF has not been investigated.

Methods: Patients with CHF (n = 15) and healthy volunteers (n = 9) were enrolled between 2006 and 2007 into this observational study. Read More

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http://dx.doi.org/10.1038/ncpcardio1364DOI Listing
December 2008
7 Reads

Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future.

Nat Clin Pract Cardiovasc Med 2008 Dec 28;5(12):766-80. Epub 2008 Oct 28.

Thrombosis Service, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON L8L2X2, Canada.

Aspirin is the foundation antiplatelet therapy for patients at risk of cardiovascular events. The thienopyridine, clopidogrel, is modestly more effective than aspirin and in patients with stroke seems to be as effective as the combination of aspirin and dipyridamole. The addition of clopidogrel to aspirin further reduces the risk of cardiovascular events in patients with acute coronary syndromes and those who undergo percutaneous coronary intervention, but uncertainty remains about whether this combination has incremental efficacy over clopidogrel monotherapy in patients with stroke or peripheral arterial disease. Read More

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http://dx.doi.org/10.1038/ncpcardio1372DOI Listing
December 2008
5 Reads

Atrial Fibrillation and Congestive Heart Failure: should we aim to control the heart's rate or its rhythm?

Nat Clin Pract Cardiovasc Med 2009 Jan 28;6(1):6-7. Epub 2008 Oct 28.

University of Ancona, Italy.

The Atrial Fibrillation and Congestive Heart Failure trial, which was conducted in patients with a reduced left ventricular ejection fraction, demonstrates that prognosis is independent of whether treatment is targeted towards controlling the heart's rate or its rhythm. The study also showed that other factors, such as use of beta-blockers, angiotensin-converting-enzyme inhibitors, angiotensin-receptor blockers, oral anticoagulants, and implantable cardioverter-defibrillators, can have a major influence on prognosis. Antiarrhythmic drugs (primarily amiodarone) were well tolerated, and adequate rate control was achieved with adjusted doses of beta-blockers combined with digoxin. Read More

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http://dx.doi.org/10.1038/ncpcardio1377DOI Listing
January 2009
3 Reads

Are pediatricians responsible for prevention of adult cardiovascular disease?

Nat Clin Pract Cardiovasc Med 2009 Jan 28;6(1):10-1. Epub 2008 Oct 28.

University of Texas Health Science Center at San Antonio, USA.

Atherosclerosis begins in childhood with fatty streaks, which progress seamlessly to fibrous plaques in adulthood. These plaques, in turn, might rupture and cause thrombotic arterial occlusion and ischemic damage to vital organs. The earliest stages and progression of atherosclerosis in youth are influenced by the same major established risk factors for this condition in adults-dyslipidemia, hypertension, smoking, obesity, and diabetes mellitus. Read More

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http://dx.doi.org/10.1038/ncpcardio1389DOI Listing
January 2009
4 Reads

Time to welcome the elderly into clinical trials.

Nat Clin Pract Cardiovasc Med 2008 Nov;5(11):673

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http://dx.doi.org/10.1038/ncpcardio1387DOI Listing
November 2008
3 Reads

Retrospective study to identify predictors of the presence and rapid progression of aortic dilatation in patients with bicuspid aortic valves.

Nat Clin Pract Cardiovasc Med 2008 Dec 21;5(12):821-8. Epub 2008 Oct 21.

Division of Cardiology, McGill University, Montreal, QC, Canada.

Background: Aortic dilatation is common among adults with bicuspid aortic valves (BAV). Predictors of risk and progression of aortic dilatation are not well described in this setting.

Methods: We analyzed retrospective data on the presence of dilation in several aortic segments in 156 adult patients with BAV who had serial echocardiograms performed at least 1 year apart. Read More

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http://www.nature.com/articles/ncpcardio1369
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http://dx.doi.org/10.1038/ncpcardio1369DOI Listing
December 2008
7 Reads