2,157 results match your criteria Nature Reviews Urology[Journal]


Grady - the miracle monkey born from cryopreserved prepubertal testis graft.

Authors:
Annette Fenner

Nat Rev Urol 2019 Apr 12. Epub 2019 Apr 12.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0182-6DOI Listing

Ga-PSMA-11 PET enables accurate detection of recurrent disease.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Apr 10. Epub 2019 Apr 10.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0181-7DOI Listing

Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management.

Nat Rev Urol 2019 Apr 8. Epub 2019 Apr 8.

Centre for Personalized Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Australia.

The accurate identification and stratified treatment of clinically significant early-stage prostate cancer have been ongoing concerns since the outcomes of large international prostate cancer screening trials were reported. The controversy surrounding clinical and cost benefits of prostate cancer screening has highlighted the lack of strategies for discriminating high-risk disease (that requires early treatment) from low-risk disease (that could be managed using watchful waiting or active surveillance). Advances in molecular subtyping and multiomics nanotechnology-based prostate cancer risk delineation can enable refinement of prostate cancer molecular taxonomy into clinically meaningful and treatable subtypes. Read More

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http://www.nature.com/articles/s41585-019-0178-2
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http://dx.doi.org/10.1038/s41585-019-0178-2DOI Listing
April 2019
4 Reads
4.840 Impact Factor

Internet information on focal prostate cancer therapy: help or hindrance?

Nat Rev Urol 2019 Apr 5. Epub 2019 Apr 5.

Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41585-019-0180-8DOI Listing

First point-of-care PSA test for prostate cancer detection.

Nat Rev Urol 2019 Apr 4. Epub 2019 Apr 4.

The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-019-0179-1DOI Listing

The resilience of men: quality of life after prostate cancer.

Authors:
Mark S Litwin

Nat Rev Urol 2019 Apr 3. Epub 2019 Apr 3.

Department of Urology, David Geffen School of Medicine at UCLA, Department of Health Policy & Management, UCLA Fielding School of Public Health and UCLA School of Nursing, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41585-019-0176-4DOI Listing

Ambulatory urodynamic monitoring: state of the art and future directions.

Nat Rev Urol 2019 Apr 1. Epub 2019 Apr 1.

Cleveland Clinic, Glickman Urological & Kidney Institute, Cleveland, OH, USA.

Urodynamic studies are a key component of the clinical evaluation of lower urinary tract dysfunction and include filling cystometry, pressure-flow studies, uroflowmetry, urethral function tests and electromyography. However, pitfalls of traditional urodynamics include physical and emotional discomfort, artificial test conditions with catheters and rapid retrograde filling of the bladder, which result in variable diagnostic accuracy. Ambulatory urodynamic monitoring (AUM) uses physiological anterograde filling and, therefore, offers a longer and more physiologically relevant evaluation. Read More

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http://dx.doi.org/10.1038/s41585-019-0175-5DOI Listing
April 2019
3 Reads

Harnessing the mesenchymal stem cell secretome for regenerative urology.

Nat Rev Urol 2019 Mar 28. Epub 2019 Mar 28.

Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

The extensive arsenal of bioactive molecules secreted by mesenchymal stem cells (MSCs), known as the secretome, has demonstrated considerable therapeutic benefit in regenerative medicine. Investigation into the therapeutic potential of the secretome has enabled researchers to replicate the anti-inflammatory, pro-angiogenic and trophic effects of stem cells without the need for the cells themselves. Furthermore, treatment with the MSC secretome could circumvent hurdles associated with cellular therapy, including oncogenic transformation, immunoreactivity and cost. Read More

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http://dx.doi.org/10.1038/s41585-019-0169-3DOI Listing
March 2019
1 Read

Barcelona! What a beautiful (therapeutic) horizon.

Authors:
Annette Fenner

Nat Rev Urol 2019 Mar 28. Epub 2019 Mar 28.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0177-3DOI Listing
March 2019
1 Read
4.840 Impact Factor

The role of multiparametric MRI in biopsy-naive prostate cancer.

Nat Rev Urol 2019 Mar 26. Epub 2019 Mar 26.

Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/s41585-019-0173-7DOI Listing
March 2019
1 Read

MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential.

Nat Rev Urol 2019 Mar 26. Epub 2019 Mar 26.

Department of Urology, University of Kansas Medical Center, Kansas City, KS, USA.

Genitourinary cancers encompass some of the most common solid tumours and have high rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis, and a number of pro-inflammatory mediators, such as macrophage migration inhibitory factor (MIF), also promote tumorigenesis. Studies of the role of MIF (which largely functions via the type II transmembrane receptor CD74) in prostate, bladder and kidney cancers suggest that it is a pro-tumorigenic factor in genitourinary malignancy. Read More

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http://dx.doi.org/10.1038/s41585-019-0171-9DOI Listing
March 2019
1 Read

Disagreement in risk groups for metastatic renal cancer.

Nat Rev Urol 2019 Mar 25. Epub 2019 Mar 25.

Department of Surgery, University of Cambridge, Cambridge, UK.

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http://www.nature.com/articles/s41585-019-0174-6
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http://dx.doi.org/10.1038/s41585-019-0174-6DOI Listing
March 2019
3 Reads

Continence in nursing homes: a state of irreversible decline?

Authors:
Adrian Wagg

Nat Rev Urol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine, University of Alberta, Alberta, Canada.

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http://dx.doi.org/10.1038/s41585-019-0172-8DOI Listing

To see or not to see - what renders prostate cancer visible?

Authors:
Mark Emberton

Nat Rev Urol 2019 Mar 13. Epub 2019 Mar 13.

Division of Surgery and Interventional Science, University College London, London, UK.

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http://dx.doi.org/10.1038/s41585-019-0167-5DOI Listing

Plazomicin once daily effective for complicated UTI.

Authors:
Annette Fenner

Nat Rev Urol 2019 Mar 8. Epub 2019 Mar 8.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0170-xDOI Listing
March 2019
4.840 Impact Factor

AR-V7 - repress to impress.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Mar 6. Epub 2019 Mar 6.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0166-6DOI Listing

2019 ASCO Genitourinary Cancers Symposium.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Apr;16(4):207

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0168-4DOI Listing
April 2019
1 Read

The influence of BRCA2 mutation on localized prostate cancer.

Nat Rev Urol 2019 Feb 26. Epub 2019 Feb 26.

Monash Partners Comprehensive Cancer Consortium and Cancer Program, Biomedicine Discovery Institute, Prostate Cancer Research Group, Department of Anatomy and Developmental Biology and Department of Physiology, Monash University, Melbourne, Victoria, Australia.

A key challenge in the management of localized prostate cancer is the identification of men with a high likelihood of progression to an advanced, incurable stage. Patients who harbour germline BRCA2 mutations have worse clinical outcomes than noncarriers when treated with surgery or radiotherapy. Insights from different disciplines have improved our understanding of why patients with BRCA2-mutant tumours have a high likelihood of failing on conventional management after diagnosis. Read More

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http://dx.doi.org/10.1038/s41585-019-0164-8DOI Listing
February 2019
1 Read

CRPC-specific gene therapy.

Authors:
Louise Stone

Nat Rev Urol 2019 Apr;16(4):206-207

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0165-7DOI Listing
April 2019
2 Reads

Routine screening for hepatitis C in MSM on HIV PrEP.

Nat Rev Urol 2019 Feb 19. Epub 2019 Feb 19.

Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41585-019-0163-9DOI Listing
February 2019

Prostate cancer: a tale of two sides.

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Nat Rev Urol 2019 Mar;16(3):141

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http://dx.doi.org/10.1038/s41585-019-0152-zDOI Listing

Both sides of the scalpel: the patient and the surgeon view.

Nat Rev Urol 2019 Mar;16(3):153-158

Guy's and St Thomas' NHS Foundation Trust, London, UK.

As clinicians and surgeons, the experience of prostate cancer is one that happens on an almost daily basis. We are used to the feeling of making a diagnosis, to reassuring our patients, to the calm and sterility of an operating theatre, and to the worry of waiting for pathology results. For our patients, this experience is new and often terrifying, and only rarely do we consider the two experiences - doctor and patient - together. Read More

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http://dx.doi.org/10.1038/s41585-019-0153-yDOI Listing

Epigenetic drugs and their molecular targets in testicular germ cell tumours.

Nat Rev Urol 2019 Apr;16(4):245-259

Institute of Pathology, Department of Developmental Pathology, University of Bonn Medical School, Bonn, Germany.

Current treatment regimens for type II testicular germ cell tumours (TGCTs) achieve cure rates of ≥95%; however, 1-5% of TGCTs develop resistance to standard platinum-based chemotherapy. Patients with recurrent TGCT typically receive high-dose chemotherapy, but this treatment results in severe adverse effects and cytotoxicity. Thus, alternative treatment options should be considered to improve patient well-being and quality of life. Read More

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http://dx.doi.org/10.1038/s41585-019-0154-xDOI Listing
April 2019
1 Read
4.840 Impact Factor

Innovative device illuminates the horizon of bioelectronic medicines.

Nat Rev Urol 2019 Apr;16(4):209-210

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1038/s41585-019-0155-9DOI Listing

IBD as a risk factor for prostate cancer: what is the link?

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-019-0157-7DOI Listing
February 2019
5 Reads

Urethral macrophages - a new HIV-1 reservoir.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Apr;16(4):205

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0158-6DOI Listing
April 2019
1 Read

Treatment timing well tolerated in bladder cancer.

Authors:
Louise Stone

Nat Rev Urol 2019 Apr;16(4):206

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0162-xDOI Listing

PSMA ADC shows promise in advanced disease.

Authors:
Louise Stone

Nat Rev Urol 2019 Apr;16(4):206

Nature Reviews Urology, .

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http://www.nature.com/articles/s41585-019-0161-y
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http://dx.doi.org/10.1038/s41585-019-0161-yDOI Listing
April 2019
4 Reads

Therapy affected by tumour microenvironment.

Authors:
Louise Stone

Nat Rev Urol 2019 Apr;16(4):206

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0160-zDOI Listing

Steaming ahead with BPH therapy.

Authors:
Louise Stone

Nat Rev Urol 2019 Apr;16(4):206

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0159-5DOI Listing
April 2019
1 Read

Understanding, justifying, and optimizing radiation exposure for CT imaging in nephrourology.

Nat Rev Urol 2019 Apr;16(4):231-244

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

An estimated 4-5 million CT scans are performed in the USA every year to investigate nephrourological diseases such as urinary stones and renal masses. Despite the clinical benefits of CT imaging, concerns remain regarding the potential risks associated with exposure to ionizing radiation. To assess the potential risk of harmful biological effects from exposure to ionizing radiation, understanding the mechanisms by which radiation damage and repair occur is essential. Read More

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http://www.nature.com/articles/s41585-019-0148-8
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http://dx.doi.org/10.1038/s41585-019-0148-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447446PMC
April 2019
8 Reads

Emerging role for the unfolded protein response.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Apr;16(4):206-207

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0156-8DOI Listing

Is bacterial prostatitis a urinary tract infection?

Nat Rev Urol 2019 Apr;16(4):203-204

Department of Immunology, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1038/s41585-019-0150-1DOI Listing
April 2019
1 Read

Persistence and clinical relevance of Zika virus in the male genital tract.

Nat Rev Urol 2019 Apr;16(4):211-230

Laboratory of Clinical Cytology and Semen Analysis, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.

Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Read More

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http://www.nature.com/articles/s41585-019-0149-7
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http://dx.doi.org/10.1038/s41585-019-0149-7DOI Listing
April 2019
6 Reads

Putting a SOCS in prostate cancer.

Authors:
Louise Stone

Nat Rev Urol 2019 Mar;16(3):147

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0151-0DOI Listing

Clarifying the link between ibuprofen and hypogonadism.

Nat Rev Urol 2019 Mar;16(3):201

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085, F-35000 Rennes, France.

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http://dx.doi.org/10.1038/s41585-019-0146-xDOI Listing
March 2019
2 Reads

Understanding sexual arousal and subjective-genital arousal desynchrony in women.

Nat Rev Urol 2019 Feb;16(2):107-120

Department of Psychology, The University of Texas at Austin, Austin, TX, USA.

Sexual arousal in women comprises two components: genital arousal and subjective arousal. Genital arousal is characterized by genital vasocongestion and other physiological changes that occur in response to sexual stimuli, whereas subjective arousal refers to mental engagement during sexual activity. For some women, genital arousal enhances subjective arousal; for others, the two types of arousal are desynchronous. Read More

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http://dx.doi.org/10.1038/s41585-018-0142-6DOI Listing
February 2019
2 Reads

A new class of AR antagonists?

Authors:
Annette Fenner

Nat Rev Urol 2019 Mar;16(3):146-147

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0147-9DOI Listing
March 2019
1 Read
4.840 Impact Factor

Large-scale genomic comparison of UTUC and bladder tumours.

Authors:
Lars Dyrskjøt

Nat Rev Urol 2019 Mar;16(3):149-150

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41585-019-0145-yDOI Listing
March 2019
2 Reads

Technologies for image-guided surgery for managing lymphatic metastases in prostate cancer.

Nat Rev Urol 2019 Mar;16(3):159-171

Martini Klinik, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

One of the challenges for the surgical management of prostate cancer is the lymphatic spread of metastases. Lymph node metastases vary in size (micrometastases (<2 mm) or macrometastases (>2 mm)), and their interactions with the lymphatic environment differ (whether they are hypoxic or connected to blood flow). Thus, devising a universal imaging system and an image-guided surgical approach that supports the resection of all affected lymph nodes is difficult. Read More

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http://www.nature.com/articles/s41585-018-0140-8
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http://dx.doi.org/10.1038/s41585-018-0140-8DOI Listing
March 2019
16 Reads

Video review for measuring and improving skill in urological surgery.

Nat Rev Urol 2019 Apr;16(4):261-267

Department of Urology, University of Michigan, Ann Arbor, MI, USA.

Interest is growing within the urological surgery community for objective assessments of technical skill. Surgical video review relies on the use of objective assessment tools to evaluate both global and procedure-specific skill. These evaluations provide structured feedback to surgeons with the aim of improving technique, which has been associated with patient outcomes. Read More

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http://www.nature.com/articles/s41585-018-0138-2
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http://dx.doi.org/10.1038/s41585-018-0138-2DOI Listing
April 2019
1 Read

Salvage prostatectomy for recurrent disease.

Nat Rev Urol 2019 Mar;16(3):150-151

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41585-018-0143-5DOI Listing
March 2019
1 Read

Evolutionary and clinical trajectories of early-onset prostate cancer.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Mar;16(3):145

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0144-zDOI Listing
March 2019
1 Read

Hyperpolarized MRI illustrates metabolic response to therapy.

Authors:
Annette Fenner

Nat Rev Urol 2019 Mar;16(3):146-147

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0139-1DOI Listing
March 2019
1 Read
4.840 Impact Factor

Refining existing knowledge and management of bladder cancer.

Nat Rev Urol 2019 Feb;16(2):75-76

Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41585-018-0137-3DOI Listing
February 2019
2 Reads

ERCC2 mutations drive cisplatin sensitivity.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb;16(2):67

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0141-7DOI Listing
February 2019
1 Read

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Nat Rev Urol 2019 Mar;16(3):187-200

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

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http://www.nature.com/articles/s41585-018-0135-5
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http://dx.doi.org/10.1038/s41585-018-0135-5DOI Listing
March 2019
17 Reads

Practice changing for prostate cancer: a vision of the future.

Nat Rev Urol 2019 Feb;16(2):71-72

Department of Nuclear Medicine, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41585-018-0134-6DOI Listing
February 2019
5 Reads

Reviving regenerative urology.

Nat Rev Urol 2019 Mar;16(3):143-144

Klinikum Lippe, Klinik für Urologie, Detmold, Germany.

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http://www.nature.com/articles/s41585-018-0131-9
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http://dx.doi.org/10.1038/s41585-018-0131-9DOI Listing
March 2019
18 Reads

Combination therapy for advanced and metastatic kidney cancer.

Nat Rev Urol 2019 Feb;16(2):77-78

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41585-018-0133-7
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http://dx.doi.org/10.1038/s41585-018-0133-7DOI Listing
February 2019
14 Reads