2,138 results match your criteria Nature Reviews Urology[Journal]


Epigenetic drugs and their molecular targets in testicular germ cell tumours.

Nat Rev Urol 2019 Feb 14. Epub 2019 Feb 14.

Institute of Pathology, Department of Developmental Pathology, University of Bonn Medical School, Bonn, Germany.

Current treatment regimens for type II testicular germ cell tumours (TGCTs) achieve cure rates of ≥95%; however, 1-5% of TGCTs develop resistance to standard platinum-based chemotherapy. Patients with recurrent TGCT typically receive high-dose chemotherapy, but this treatment results in severe adverse effects and cytotoxicity. Thus, alternative treatment options should be considered to improve patient well-being and quality of life. Read More

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http://dx.doi.org/10.1038/s41585-019-0154-xDOI Listing
February 2019

Innovative device illuminates the horizon of bioelectronic medicines.

Nat Rev Urol 2019 Feb 13. Epub 2019 Feb 13.

Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1038/s41585-019-0155-9DOI Listing
February 2019

IBD as a risk factor for prostate cancer: what is the link?

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-019-0157-7DOI Listing
February 2019
1 Read

Urethral macrophages - a new HIV-1 reservoir.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0158-6DOI Listing
February 2019
1 Read

Treatment timing well tolerated in bladder cancer.

Authors:
Louise Stone

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0162-xDOI Listing
February 2019

PSMA ADC shows promise in advanced disease.

Authors:
Louise Stone

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Nature Reviews Urology, .

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http://www.nature.com/articles/s41585-019-0161-y
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February 2019
1 Read

Therapy affected by tumour microenvironment.

Authors:
Louise Stone

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0160-zDOI Listing
February 2019

Steaming ahead with BPH therapy.

Authors:
Louise Stone

Nat Rev Urol 2019 Feb 11. Epub 2019 Feb 11.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0159-5DOI Listing
February 2019
1 Read

Understanding, justifying, and optimizing radiation exposure for CT imaging in nephrourology.

Nat Rev Urol 2019 Feb 6. Epub 2019 Feb 6.

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

An estimated 4-5 million CT scans are performed in the USA every year to investigate nephrourological diseases such as urinary stones and renal masses. Despite the clinical benefits of CT imaging, concerns remain regarding the potential risks associated with exposure to ionizing radiation. To assess the potential risk of harmful biological effects from exposure to ionizing radiation, understanding the mechanisms by which radiation damage and repair occur is essential. Read More

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http://www.nature.com/articles/s41585-019-0148-8
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February 2019
1 Read

Emerging role for the unfolded protein response.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb 4. Epub 2019 Feb 4.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0156-8DOI Listing
February 2019

Is bacterial prostatitis a urinary tract infection?

Nat Rev Urol 2019 Jan 30. Epub 2019 Jan 30.

Department of Immunology, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1038/s41585-019-0150-1DOI Listing
January 2019

Persistence and clinical relevance of Zika virus in the male genital tract.

Nat Rev Urol 2019 Jan 29. Epub 2019 Jan 29.

Laboratory of Clinical Cytology and Semen Analysis, Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, PR, Brazil.

Zika virus (ZIKV) is a re-emerging mosquito-transmitted flavivirus associated with congenital abnormalities in newborns and with Guillain-Barré syndrome in adults. The virus can also be sexually transmitted and can persist in the male genital tract. Studies evaluating the kinetics of ZIKV in seminal shedding of men who have been infected, as well as in animal and cellular models of infection, have shown that, in addition to the testis and epididymis, the prostate and seminal vesicles could also be involved in persistent ZIKV infection. Read More

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http://www.nature.com/articles/s41585-019-0149-7
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January 2019
4 Reads

Putting a SOCS in prostate cancer.

Authors:
Louise Stone

Nat Rev Urol 2019 Jan 28. Epub 2019 Jan 28.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0151-0DOI Listing
January 2019

Clarifying the link between ibuprofen and hypogonadism.

Nat Rev Urol 2019 Jan 21. Epub 2019 Jan 21.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085, F-35000 Rennes, France.

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http://dx.doi.org/10.1038/s41585-019-0146-xDOI Listing
January 2019
1 Read

Understanding sexual arousal and subjective-genital arousal desynchrony in women.

Nat Rev Urol 2019 Feb;16(2):107-120

Department of Psychology, The University of Texas at Austin, Austin, TX, USA.

Sexual arousal in women comprises two components: genital arousal and subjective arousal. Genital arousal is characterized by genital vasocongestion and other physiological changes that occur in response to sexual stimuli, whereas subjective arousal refers to mental engagement during sexual activity. For some women, genital arousal enhances subjective arousal; for others, the two types of arousal are desynchronous. Read More

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http://dx.doi.org/10.1038/s41585-018-0142-6DOI Listing
February 2019
2 Reads

A new class of AR antagonists?

Authors:
Annette Fenner

Nat Rev Urol 2019 Jan 21. Epub 2019 Jan 21.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0147-9DOI Listing
January 2019
1 Read
4.840 Impact Factor

Large-scale genomic comparison of UTUC and bladder tumours.

Authors:
Lars Dyrskjøt

Nat Rev Urol 2019 Jan 15. Epub 2019 Jan 15.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

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http://dx.doi.org/10.1038/s41585-019-0145-yDOI Listing
January 2019
1 Read

Technologies for image-guided surgery for managing lymphatic metastases in prostate cancer.

Nat Rev Urol 2019 Jan 15. Epub 2019 Jan 15.

Martini Klinik, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

One of the challenges for the surgical management of prostate cancer is the lymphatic spread of metastases. Lymph node metastases vary in size (micrometastases (<2 mm) or macrometastases (>2 mm)), and their interactions with the lymphatic environment differ (whether they are hypoxic or connected to blood flow). Thus, devising a universal imaging system and an image-guided surgical approach that supports the resection of all affected lymph nodes is difficult. Read More

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http://www.nature.com/articles/s41585-018-0140-8
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January 2019
5 Reads

Video review for measuring and improving skill in urological surgery.

Nat Rev Urol 2019 Jan 8. Epub 2019 Jan 8.

Department of Urology, University of Michigan, Ann Arbor, MI, USA.

Interest is growing within the urological surgery community for objective assessments of technical skill. Surgical video review relies on the use of objective assessment tools to evaluate both global and procedure-specific skill. These evaluations provide structured feedback to surgeons with the aim of improving technique, which has been associated with patient outcomes. Read More

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http://www.nature.com/articles/s41585-018-0138-2
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January 2019
1 Read

Salvage prostatectomy for recurrent disease.

Nat Rev Urol 2019 Jan 7. Epub 2019 Jan 7.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/s41585-018-0143-5DOI Listing
January 2019
1 Read

Evolutionary and clinical trajectories of early-onset prostate cancer.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Jan 4. Epub 2019 Jan 4.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-019-0144-zDOI Listing
January 2019
1 Read

Hyperpolarized MRI illustrates metabolic response to therapy.

Authors:
Annette Fenner

Nat Rev Urol 2019 Jan 3. Epub 2019 Jan 3.

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0139-1DOI Listing
January 2019
1 Read
4.840 Impact Factor

Refining existing knowledge and management of bladder cancer.

Nat Rev Urol 2019 Feb;16(2):75-76

Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41585-018-0137-3DOI Listing
February 2019
2 Reads

ERCC2 mutations drive cisplatin sensitivity.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb;16(2):67

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0141-7DOI Listing
February 2019
1 Read

Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Nat Rev Urol 2018 Dec 18. Epub 2018 Dec 18.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, USA.

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. Read More

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http://www.nature.com/articles/s41585-018-0135-5
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December 2018
11 Reads

Practice changing for prostate cancer: a vision of the future.

Nat Rev Urol 2019 Feb;16(2):71-72

Department of Nuclear Medicine, Technical University of Munich, Munich, Germany.

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http://dx.doi.org/10.1038/s41585-018-0134-6DOI Listing
February 2019
1 Read

Reviving regenerative urology.

Nat Rev Urol 2018 Dec 13. Epub 2018 Dec 13.

Klinikum Lippe, Klinik für Urologie, Detmold, Germany.

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http://www.nature.com/articles/s41585-018-0131-9
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December 2018
7 Reads

Combination therapy for advanced and metastatic kidney cancer.

Nat Rev Urol 2019 Feb;16(2):77-78

Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41585-018-0133-7
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February 2019
8 Reads

ONECUT2 many towards AR-independence.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb;16(2):65

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0136-4DOI Listing
February 2019
1 Read

Efficacy of a novel single-dose oral antibiotic for urogenital gonorrhoea.

Authors:
Annette Fenner

Nat Rev Urol 2019 Feb;16(2):66

Nature Reviews Urology, .

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http://www.nature.com/articles/s41585-018-0130-x
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February 2019
7 Reads
4.840 Impact Factor

Mitochondrial metabolism: a target in AR-driven disease.

Authors:
Louise Stone

Nat Rev Urol 2019 01;16(1)

Nature Reviews Urology, .

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http://www.nature.com/articles/s41585-018-0132-8
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http://dx.doi.org/10.1038/s41585-018-0132-8DOI Listing
January 2019
7 Reads

Urobiome updates: advances in urinary microbiome research.

Nat Rev Urol 2019 Feb;16(2):73-74

Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Female Pelvic Medicine and Reconstructive Surgery, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1038/s41585-018-0127-5DOI Listing
February 2019
1 Read

No survival benefit with extended lymphadenectomy: now what?

Nat Rev Urol 2019 01;16(1):3-4

Department of Urology, University of Bern, Inselspital, Bern, Switzerland.

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http://dx.doi.org/10.1038/s41585-018-0126-6DOI Listing
January 2019
2 Reads

PARP inhibition - not all gene mutations are created equal.

Nat Rev Urol 2019 Jan;16(1):4-6

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1038/s41585-018-0129-3DOI Listing
January 2019
1 Read

Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies.

Nat Rev Urol 2019 01;16(1):7-22

The James Buchanan Brady Urological Institute, Baltimore, MD, USA.

Despite improvements in early detection and advances in treatment, patients with prostate cancer continue to die from their disease. Minimal residual disease after primary definitive treatment can lead to relapse and distant metastases, and increasing evidence suggests that circulating tumour cells (CTCs) and bone marrow-derived disseminated tumour cells (BM-DTCs) can offer clinically relevant biological insights into prostate cancer dissemination and metastasis. Using epithelial markers to accurately detect CTCs and BM-DTCs is associated with difficulties, and prostate-specific markers are needed for the detection of these cells using rare cell assays. Read More

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http://dx.doi.org/10.1038/s41585-018-0119-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324967PMC
January 2019
3 Reads

From EMUC18.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb;16(2):66-67

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0128-4DOI Listing
February 2019
1 Read

Current insights into the mechanisms and management of infection stones.

Nat Rev Urol 2019 Jan;16(1):35-53

Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA.

Infection stones are complex aggregates of crystals amalgamated in an organic matrix that are strictly associated with urinary tract infections. The management of patients who form infection stones is challenging owing to the complexity of the calculi and high recurrence rates. The formation of infection stones is a multifactorial process that can be driven by urine chemistry, the urine microenvironment, the presence of modulator substances in urine, associations with bacteria, and the development of biofilms. Read More

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http://dx.doi.org/10.1038/s41585-018-0120-zDOI Listing
January 2019
18 Reads

Diagnosis and management of urinary extravasation after high-grade renal trauma.

Nat Rev Urol 2019 Jan;16(1):54-64

Division of Urology, Department of Surgery, University of Utah, Salt Lake City, UT, USA.

Renal trauma research has historically focused on parenchymal injuries and the risk of bleeding. However, much less is known about the diagnosis and optimal management of urinary extravasation, which complicates ~30% of high-grade renal injuries. Immediate or delayed ureteral stenting is the most common procedure used to treat collecting system injuries when intervention is needed. Read More

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http://dx.doi.org/10.1038/s41585-018-0122-xDOI Listing
January 2019
2 Reads

Immunotherapy for lethal prostate cancer.

Nat Rev Urol 2019 Feb;16(2):69-70

Division of Clinical Studies, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/s41585-018-0121-yDOI Listing
February 2019
12 Reads

TECs support the SSC niche.

Authors:
Louise Stone

Nat Rev Urol 2019 01;16(1)

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0123-9DOI Listing
January 2019
1 Read

Penile traction therapy - efficacy in PD.

Authors:
Conor A Bradley

Nat Rev Urol 2019 Feb;16(2):66-67

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0125-7DOI Listing
February 2019
1 Read

eCoin device stops patients from spending a penny.

Authors:
Annette Fenner

Nat Rev Urol 2019 Jan;16(1)

Nature Reviews Urology, .

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http://dx.doi.org/10.1038/s41585-018-0124-8DOI Listing
January 2019
1 Read
4.840 Impact Factor

Nonsurgical management of Peyronie's disease.

Nat Rev Urol 2018 Nov 5. Epub 2018 Nov 5.

Rush University Medical Center, Chicago, IL, USA.

Peyronie's disease is not a rare disorder, and it can be devastating to the affected man. Although the gold-standard treatment of Peyronie's disease is surgery in the stable phase, nonoperative management is preferred by some men and is the only treatment option in the acute phase of the disease, when surgery is contraindicated. No oral or topical therapy has been shown to be efficacious when administered alone, but some evidence supports their use as part of a combination therapy regimen. Read More

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http://dx.doi.org/10.1038/s41585-018-0117-7DOI Listing
November 2018
1 Read

Penis evolution across species: divergence and diversity.

Nat Rev Urol 2019 Feb;16(2):98-106

Centre for Ecology & Conservation, University of Exeter, Cornwall, Penryn, UK.

The penis is an incredibly diverse and rapidly evolving structure, such that even in closely related species that otherwise differ very little in their morphology, penis form can be highly differentiated. Penises are also much more complex than their fundamental function - sperm transfer - would seem to require. The rapid divergent evolution of male structures is typically the signature of traits under sexual selection and the current evidence suggests the penis is no different in this regard. Read More

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http://www.nature.com/articles/s41585-018-0112-z
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February 2019
11 Reads

The psychological toll of prostate cancer.

Nat Rev Urol 2018 Dec;15(12):733-734

Australian Prostate Cancer Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia.

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http://www.nature.com/articles/s41585-018-0111-0
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December 2018
3 Reads

Supporting sexuality and improving sexual function in transgender persons.

Nat Rev Urol 2019 Feb;16(2):121-139

ANOVA, Karolinska University Hospital, Norra Stationsgatan 69, Stockholm, Sweden.

Sexuality is important for most cisgender as well as transgender persons and is an essential aspect of quality of life. For both the patient and their clinicians, managing gender dysphoria includes establishing a comfortable relationship with sexual health issues, which can evolve throughout the course of gender-affirming treatment. Gender-affirming endocrine treatment of transgender men and women has considerable effects on sex drive and sexual function. Read More

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http://www.nature.com/articles/s41585-018-0108-8
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February 2019
20 Reads

The Warburg effect in hominis: isotope-resolved metabolism in ccRCC.

Nat Rev Urol 2018 Dec;15(12):731-732

Urologic Oncology Branch, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41585-018-0110-1DOI Listing
December 2018
1 Read

The mechanisms and potential of stem cell therapy for penile fibrosis.

Nat Rev Urol 2019 Feb;16(2):79-97

Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Fibrosis is often caused by chronic tissue injury leading to a persisting inflammatory response with excessive accumulation of extracellular connective tissue proteins. Peyronie's disease, urethral stricture and penile (corpora cavernosa) fibrosis are localized fibrotic disorders of the penile connective tissues that can substantially impair a patient's quality of life. Research over the past few decades has revealed the ability of stem cells to secrete a wide range of paracrine factors, a characteristic that could be exploited therapeutically to prevent and treat several inflammatory and fibrotic diseases. Read More

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http://dx.doi.org/10.1038/s41585-018-0109-7DOI Listing
February 2019
1 Read

IL-23 links glutamine addiction and immune function.

Authors:
Conor A Bradley

Nat Rev Urol 2018 Dec;15(12):725

Nature Reviews Urology, .

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http://www.nature.com/articles/s41585-018-0118-6
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December 2018
6 Reads

Nonantibiotic prevention and management of recurrent urinary tract infection.

Nat Rev Urol 2018 Dec;15(12):750-776

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Urinary tract infections (UTIs) are highly prevalent, lead to considerable patient morbidity, incur large financial costs to health-care systems and are one of the most common reasons for antibiotic use worldwide. The growing problem of antimicrobial resistance means that the search for nonantibiotic alternatives for the treatment and prevention of UTI is of critical importance. Potential nonantibiotic measures and treatments for UTIs include behavioural changes, dietary supplementation (such as Chinese herbal medicines and cranberry products), NSAIDs, probiotics, D-mannose, methenamine hippurate, estrogens, intravesical glycosaminoglycans, immunostimulants, vaccines and inoculation with less-pathogenic bacteria. Read More

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http://www.nature.com/articles/s41585-018-0106-x
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December 2018
20 Reads