1,863 results match your criteria Nature Reviews Rheumatology[Journal]


Anti-IL-1 for the treatment of OA: dead or alive?

Nat Rev Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Rheumatology, Hospital Henri Mondor, UPEC Paris XII, Créteil, France.

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http://dx.doi.org/10.1038/s41584-019-0185-yDOI Listing
February 2019

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility.

Nat Rev Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine and St Vincent's Institute, University of Melbourne, Melbourne, Victoria, Australia.

Bone volume, microstructure and its material composition are maintained by bone remodelling, a cellular activity carried out by bone multicellular units (BMUs). BMUs are focally transient teams of osteoclasts and osteoblasts that respectively resorb a volume of old bone and then deposit an equal volume of new bone at the same location. Around the time of menopause, bone remodelling becomes unbalanced and rapid, and an increased number of BMUs deposit less bone than they resorb, resulting in bone loss, a reduction in bone volume and microstructural deterioration. Read More

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http://dx.doi.org/10.1038/s41584-019-0172-3DOI Listing
February 2019

Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition.

Nat Rev Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.

Psoriasis is one of the most common chronic inflammatory skin diseases, affecting 3% of the world's population, and approximately one-third of patients with psoriasis will eventually transition to having psoriatic arthritis (PsA). The evolution from cutaneous to synovio-entheseal inflammation in these patients presents an opportunity to investigate the critical events linked to arthritis development. The events responsible for progression to PsA are currently unclear. Read More

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http://dx.doi.org/10.1038/s41584-019-0175-0DOI Listing
February 2019
1 Read

Disease modification in OA - will we ever get there?

Nat Rev Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

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http://dx.doi.org/10.1038/s41584-019-0174-1DOI Listing
February 2019

Calculating TNF dynamics.

Nat Rev Rheumatol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0183-0DOI Listing
February 2019

Defective T cell checkpoint in SLE.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0182-1DOI Listing
February 2019

Sensing bone mass.

Nat Rev Rheumatol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0181-2DOI Listing
February 2019

OA genetic risk loci more than doubled.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0179-9DOI Listing
February 2019

Assisted reproduction less effective in RA.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0178-xDOI Listing
February 2019

Lung biomarkers in SSc: prognostic or diagnostic?

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0177-yDOI Listing
February 2019

Belimumab slows organ damage progression.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0176-zDOI Listing
February 2019

Unmasking the double life of ELMO1.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0180-3DOI Listing
February 2019

Treat-to-target in rheumatoid arthritis - are we there yet?

Nat Rev Rheumatol 2019 Jan 30. Epub 2019 Jan 30.

Amsterdam University Medical Centers, Amsterdam, Netherlands.

Treat-to-target has been established as a guiding principle for the treatment of rheumatoid arthritis (RA) and encompasses several distinct elements: choosing a target and a method for measuring it; assessing the target at a pre-specified time point; a commitment to change the therapy if the target is not achieved; and shared decision-making. A treat-to-target approach yields superior outcomes to standard care in RA, and the ACR, EULAR and other professional organizations have endorsed treat-to-target as a fundamental therapeutic strategy for RA. Nevertheless, data on the degree to which treat-to-target is employed in the clinic are scarce; it seems that although some elements of treat-to-target are widely used, full implementation remains uncommon. Read More

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http://www.nature.com/articles/s41584-019-0170-5
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http://dx.doi.org/10.1038/s41584-019-0170-5DOI Listing
January 2019
3 Reads

GWAS cracks fracture risk.

Nat Rev Rheumatol 2019 Jan 29. Epub 2019 Jan 29.

Associate Editor Nature Communications, .

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http://dx.doi.org/10.1038/s41584-019-0173-2DOI Listing
January 2019

Characterizing the autoreactive B cell transcriptome.

Authors:
Jeremy Sokolove

Nat Rev Rheumatol 2019 Jan 24. Epub 2019 Jan 24.

Division of Immunology and Rheumatology, VA Palo Alto Healthcare System and Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41584-019-0169-yDOI Listing
January 2019

How T cells lose FOXP3.

Nat Rev Rheumatol 2019 Jan 22. Epub 2019 Jan 22.

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0171-4DOI Listing
January 2019
1 Read

Neuropsychiatric lupus: new mechanistic insights and future treatment directions.

Nat Rev Rheumatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.

Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS manifestations of SLE are diverse and have a broad spectrum of severity and prognostic implications. Patients with NPSLE typically present with nonspecific symptoms, such as headache and cognitive impairment, but might also experience devastating features, such as memory loss, seizures and stroke. Read More

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http://dx.doi.org/10.1038/s41584-018-0156-8DOI Listing
January 2019
3 Reads

Author Correction: Pathogenesis and therapeutic interventions for ANCA-associated vasculitis.

Nat Rev Rheumatol 2019 Feb;15(2):123

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

In the originally published online version of this article there were errors in the Supplementary Information. All three Supplementary Tables had incorrectly numbered references. These errors have now been corrected in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41584-019-0168-zDOI Listing
February 2019
1 Read

Promising drug delivery system.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb;15(2):64

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0158-1DOI Listing
February 2019
2 Reads

IVD progenitor cells: a new horizon for understanding disc homeostasis and repair.

Nat Rev Rheumatol 2019 Feb;15(2):102-112

Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Intervertebral disc (IVD) degeneration is associated with low back pain. In IVDs, a high mechanical load, high osmotic pressure and hypoxic conditions create a hostile microenvironment for resident cells. How IVD homeostasis and function are maintained under stress remains to be understood; however, several research groups have reported isolating native endogenous progenitor-like or otherwise proliferative cells from the IVD. Read More

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http://dx.doi.org/10.1038/s41584-018-0154-xDOI Listing
February 2019
1 Read
9.845 Impact Factor

Author Correction: Pathogenic bone marrow B cells.

Nat Rev Rheumatol 2019 Feb;15(2):123

Nature Reviews Rheumatology, .

In the originally published online version of this article there was an error in the page number of the reference to the original article published in Nature Communications, and the associated link was therefore incorrect. The page number was listed as 5217 and should have been 5127. This error has now been corrected in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41584-019-0167-0DOI Listing
February 2019
1 Read

ACPA epitopes - what are we actually looking at?

Nat Rev Rheumatol 2019 Jan 9. Epub 2019 Jan 9.

Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41584-018-0157-7DOI Listing
January 2019
2 Reads

Pathogenic bone marrow B cells.

Nat Rev Rheumatol 2019 Feb;15(2):65

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0166-1DOI Listing
February 2019
1 Read

Dietary modulation of the microbiome as therapy.

Nat Rev Rheumatol 2019 Feb;15(2):66

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0165-2DOI Listing
February 2019
1 Read

Selective Janus kinase inhibitors come of age.

Nat Rev Rheumatol 2019 Feb;15(2):74-75

Translational Immunology Section, National Institutes of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41584-018-0155-9DOI Listing
February 2019
1 Read

Moving towards tissue-engineered disc replacement.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Feb;15(2):66

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0159-0DOI Listing
February 2019
1 Read

Extracellular matrix in the crosshairs.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb;15(2):65

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0160-7DOI Listing
February 2019
1 Read

Cell migration: implications for repair and regeneration in joint disease.

Nat Rev Rheumatol 2019 Jan 7. Epub 2019 Jan 7.

McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Washington University, St Louis, MO, USA.

Connective tissues within the synovial joints are characterized by their dense extracellular matrix and sparse cellularity. With injury or disease, however, tissues commonly experience an influx of cells owing to proliferation and migration of endogenous mesenchymal cell populations, as well as invasion of the tissue by other cell types, including immune cells. Although this process is critical for successful wound healing, aberrant immune-mediated cell infiltration can lead to pathological inflammation of the joint. Read More

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http://dx.doi.org/10.1038/s41584-018-0151-0DOI Listing
January 2019
1 Read

Cancer risk associated with anti-TIF1 antibodies.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb;15(2):64

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0164-3DOI Listing
February 2019
1 Read

No increased risk of VTE with tofacitinib.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb;15(2):64

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0162-5DOI Listing
February 2019
1 Read

Sustained remission in PsA with secukinumab.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb;15(2):64

Nature Reviews Rheumatology, .

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http://www.nature.com/articles/s41584-019-0163-4
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http://dx.doi.org/10.1038/s41584-019-0163-4DOI Listing
February 2019
4 Reads

GAG metabolism associated with PsA risk.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Feb;15(2):64

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-019-0161-6DOI Listing
February 2019
1 Read

Pathophysiology, assessment and treatment of psoriatic dactylitis.

Nat Rev Rheumatol 2019 Feb;15(2):113-122

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Dactylitis is diffuse swelling of the digits that is usually related to an underlying inflammatory or infiltrative disorder. Psoriatic arthritis (PsA) is the most common severe disease thought to cause dactylitis. Our understanding of the pathogenesis of PsA-related dactylitis comes from experimental animal models of PsA-like disease, as well as advances in imaging and other clinical studies. Read More

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http://dx.doi.org/10.1038/s41584-018-0147-9DOI Listing
February 2019
2 Reads

Overcoming natural Wnt inhibition to optimize therapy.

Authors:
Natalie A Sims

Nat Rev Rheumatol 2019 Feb;15(2):67-68

St Vincent's Institute of Medical Research and The University of Melbourne Department of Medicine, St Vincent's Hospital, Fitzroy, Victoria, Australia.

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http://dx.doi.org/10.1038/s41584-018-0153-yDOI Listing
February 2019
2 Reads

The microbiome in SLE pathogenesis.

Nat Rev Rheumatol 2019 Feb;15(2):72-74

The Laboratory of B cell immunobiology and the Division of Rheumatology, NYU School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1038/s41584-018-0152-zDOI Listing
February 2019
1 Read

Cell metabolism as a potentially targetable pathway in RA.

Nat Rev Rheumatol 2019 Feb;15(2):70-72

Molecular Rheumatology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1038/s41584-018-0148-8DOI Listing
February 2019
1 Read

A CD4 T cell population provides B cell help in SLE.

Authors:
Susan J Allison

Nat Rev Rheumatol 2019 Feb;15(2):63

Nature Reviews Nephrology, .

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http://www.nature.com/articles/s41584-018-0150-1
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http://dx.doi.org/10.1038/s41584-018-0150-1DOI Listing
February 2019
9 Reads

Prevention and treatment of gout.

Nat Rev Rheumatol 2019 Feb;15(2):68-70

Department of Medicine, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1038/s41584-018-0149-7DOI Listing
February 2019
1 Read

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis.

Nat Rev Rheumatol 2019 Feb;15(2):91-101

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the serum. This disease entity includes microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and drug-induced AAV. Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. Read More

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http://dx.doi.org/10.1038/s41584-018-0145-yDOI Listing
February 2019
2 Reads

Crosstalking with Hippo.

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0146-xDOI Listing
January 2019
1 Read

Machine-learning-based patient-specific prediction models for knee osteoarthritis.

Nat Rev Rheumatol 2019 Jan;15(1):49-60

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.

Osteoarthritis (OA) is an extremely common musculoskeletal disease. However, current guidelines are not well suited for diagnosing patients in the early stages of disease and do not discriminate patients for whom the disease might progress rapidly. The most important hurdle in OA management is identifying and classifying patients who will benefit most from treatment. Read More

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http://dx.doi.org/10.1038/s41584-018-0130-5DOI Listing
January 2019
1 Read

Chronic opioid usage on the rise in RA.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0144-zDOI Listing
January 2019
2 Reads

New therapeutic strategies in systemic lupus erythematosus management.

Nat Rev Rheumatol 2019 Jan;15(1):30-48

Unit of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.

The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the recommendations by international medical associations including EULAR and the ACR, is mostly eminence-based rather than evidence-based. However, knowledge on SLE is growing quickly, and such new advances need to be translated into clinical practice. Questions remain regarding the choice and timing of drug administration and tapering until withdrawal, which both can affect the balance between the control of disease activity and damage to organs triggered by long-standing and/or disproportionate immunosuppression. Read More

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http://www.nature.com/articles/s41584-018-0133-2
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http://dx.doi.org/10.1038/s41584-018-0133-2DOI Listing
January 2019
13 Reads

Can metabolomic profiling predict response to therapy?

Nat Rev Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1038/s41584-018-0136-zDOI Listing
December 2018
1 Read

Falls, fractures and vitamin D: a never-ending story?

Nat Rev Rheumatol 2019 Jan;15(1):6-8

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1038/s41584-018-0135-0DOI Listing
January 2019
1 Read

Wnt signalling in the gut microbiota-bone axis.

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0139-9DOI Listing
January 2019
1 Read

Preventing immune-complex-mediated disease.

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0137-yDOI Listing
January 2019
1 Read

TDP-43 in the muscles: friend or foe?

Authors:
Jessica McHugh

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0138-xDOI Listing
January 2019
1 Read

Author Correction: Decoding osteoarthritis.

Nat Rev Rheumatol 2019 Jan;15(1):61

Associate Editor, Nature Communications, .

In the online version of this article, there was an error in the text. The line beginning "A majority of the identified common variants with >5% frequency (variants with a minor allele) […]" has been corrected to "A majority of the identified common variants (variants with a minor allele frequency >5%) […]". This error has now been corrected in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41584-018-0140-3DOI Listing
January 2019
1 Read

Ultrasound thresholds for synovial abnormalities.

Authors:
Joanna Collison

Nat Rev Rheumatol 2019 Jan;15(1)

Nature Reviews Rheumatology, .

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http://dx.doi.org/10.1038/s41584-018-0143-0DOI Listing
January 2019
2 Reads