2,171 results match your criteria Nature Reviews Neuroscience [Journal]


Lasting restoration.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr 24. Epub 2019 Apr 24.

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0175-8DOI Listing

Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.

Authors:
Alain Chédotal

Nat Rev Neurosci 2019 Apr 18. Epub 2019 Apr 18.

Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

The spinal cord receives, relays and processes sensory information from the periphery and integrates this information with descending inputs from supraspinal centres to elicit precise and appropriate behavioural responses and orchestrate body movements. Understanding how the spinal cord circuits that achieve this integration are wired during development is the focus of much research interest. Several families of proteins have well-established roles in guiding developing spinal cord axons, and recent findings have identified new axon guidance molecules. Read More

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http://dx.doi.org/10.1038/s41583-019-0168-7DOI Listing
April 2019
1 Read

Grids cells go for a goal.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr 16. Epub 2019 Apr 16.

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http://dx.doi.org/10.1038/s41583-019-0170-0DOI Listing
April 2019
1 Read

Author Correction: Novel electrode technologies for neural recordings.

Nat Rev Neurosci 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

In part b of Figure 2 in this article, the left bounds of the boxes representing the spatiotemporal resolution of 'EEG/MEG' and 'ECoG' were incorrect. Specifically, the limits of highest temporal resolution for EEG/MEG and ECoG were shown as ~200 ms and ~10 ms and are now corrected to ~2 ms and < 1 ms, respectively. In addition, the lower bounds of the boxes representing 'fMRI/PET' and 'EEG/MEG' incorrectly showed the highest spatial resolution limits of these technologies as ~1 mm and have been corrected to <1 mm and <10 mm, respectively. Read More

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http://dx.doi.org/10.1038/s41583-019-0169-6DOI Listing

Putting objects in their place.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Apr 12. Epub 2019 Apr 12.

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http://dx.doi.org/10.1038/s41583-019-0172-yDOI Listing

New for old.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Apr 12. Epub 2019 Apr 12.

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http://dx.doi.org/10.1038/s41583-019-0174-9DOI Listing

Targeting senescence.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Apr 12. Epub 2019 Apr 12.

Nature Reviews Neuroscience, .

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http://www.nature.com/articles/s41583-019-0173-x
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http://dx.doi.org/10.1038/s41583-019-0173-xDOI Listing
April 2019
7 Reads

Where to eat?

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Apr 12. Epub 2019 Apr 12.

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http://www.nature.com/articles/s41583-019-0171-z
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http://dx.doi.org/10.1038/s41583-019-0171-zDOI Listing
April 2019
2 Reads

Embracing diversity in the 5-HT neuronal system.

Nat Rev Neurosci 2019 Apr 4. Epub 2019 Apr 4.

Department of Genetics, Harvard Medical School, Boston, MA, USA.

Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core set of genes that establish and maintain this neurotransmitter phenotype and distinguish these neurons from other brain cells. Beyond a shared 5-HTergic phenotype, these neurons display divergent cellular properties in relation to anatomy, morphology, hodology, electrophysiology and gene expression, including differential expression of molecules supporting co-transmission of additional neurotransmitters. This diversity suggests that functionally heterogeneous subtypes of 5-HT neurons exist, but linking subsets of these neurons to particular functions has been technically challenging. Read More

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http://dx.doi.org/10.1038/s41583-019-0151-3DOI Listing
April 2019
2 Reads

A stimulating approach.

Authors:
Darran Yates

Nat Rev Neurosci 2019 May;20(5):249

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http://dx.doi.org/10.1038/s41583-019-0167-8DOI Listing
May 2019
1 Read

Traumatized brains.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):252

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http://dx.doi.org/10.1038/s41583-019-0166-9DOI Listing

Listening to vibrations.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):252

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http://dx.doi.org/10.1038/s41583-019-0165-xDOI Listing

Double satiety.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):252

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http://dx.doi.org/10.1038/s41583-019-0164-yDOI Listing

Filtering out the noise in axon guidance.

Nat Rev Neurosci 2019 May;20(5):250-251

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http://dx.doi.org/10.1038/s41583-019-0162-0DOI Listing

Flowing with the visual stream.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):252

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http://dx.doi.org/10.1038/s41583-019-0163-zDOI Listing

Emerging connections between cerebellar development, behaviour and complex brain disorders.

Nat Rev Neurosci 2019 May;20(5):298-313

Center for Neuroscience Research, Children's Research Institute, Children's National Health System, Washington, DC, USA.

The human cerebellum has a protracted developmental timeline compared with the neocortex, expanding the window of vulnerability to neurological disorders. As the cerebellum is critical for motor behaviour, it is not surprising that most neurodevelopmental disorders share motor deficits as a common sequela. However, evidence gathered since the late 1980s suggests that the cerebellum is involved in motor and non-motor function, including cognition and emotion. Read More

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http://dx.doi.org/10.1038/s41583-019-0152-2DOI Listing
May 2019
2 Reads

Understanding rostral-caudal auditory cortex contributions to auditory perception.

Nat Rev Neurosci 2019 Mar 28. Epub 2019 Mar 28.

Institute of Cognitive Neuroscience, University College London, London, UK.

There are functional and anatomical distinctions between the neural systems involved in the recognition of sounds in the environment and those involved in the sensorimotor guidance of sound production and the spatial processing of sound. Evidence for the separation of these processes has historically come from disparate literatures on the perception and production of speech, music and other sounds. More recent evidence indicates that there are computational distinctions between the rostral and caudal primate auditory cortex that may underlie functional differences in auditory processing. Read More

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http://dx.doi.org/10.1038/s41583-019-0160-2DOI Listing

Vestibular processing during natural self-motion: implications for perception and action.

Nat Rev Neurosci 2019 Mar 27. Epub 2019 Mar 27.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

How the brain computes accurate estimates of our self-motion relative to the world and our orientation relative to gravity in order to ensure accurate perception and motor control is a fundamental neuroscientific question. Recent experiments have revealed that the vestibular system encodes this information during everyday activities using pathway-specific neural representations. Furthermore, new findings have established that vestibular signals are selectively combined with extravestibular information at the earliest stages of central vestibular processing in a manner that depends on the current behavioural goal. Read More

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http://dx.doi.org/10.1038/s41583-019-0153-1DOI Listing

Author Correction: Closed-loop brain training: the science of neurofeedback.

Nat Rev Neurosci 2019 May;20(5):314

Department of Mechanical Engineering, University of Texas at Austin, 204 E Dean Keeton Street, Austin, Texas, 78712, USA.

In this article, the affiliation for Mohit Rana was incorrectly listed as the Institute for Biological and Medical Engineering, Department of Psychiatry, and Section of Neuroscience, Pontificia Universidad Católica de Chile, Vicuña Mackenna 4860 Hernán Briones, piso 2, Macul 782-0436, Santiago, Chile. The listed affiliation should have been the following: Departamento de Psiquiatría, Escuela de Medicina, Centro Interdisciplinario de Neurociencias, Pontificia Universidad Católica de Chile, Santiago, Chile; and the Laboratory for Brain-Machine Interfaces and Neuromodulation, Pontificia Universidad Católica de Chile, Santiago, Chile. An acknowledgement to Mohit Rana's funding source was also missing. Read More

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http://www.nature.com/articles/s41583-019-0161-1
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http://dx.doi.org/10.1038/s41583-019-0161-1DOI Listing
May 2019
6 Reads

Reawakening the aged brain.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):251

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http://dx.doi.org/10.1038/s41583-019-0157-xDOI Listing

Lightening depression.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):251

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0155-zDOI Listing

The ins and outs of microglia.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):251

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0156-yDOI Listing

The mechanics of neural regeneration.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 May;20(5):251

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http://dx.doi.org/10.1038/s41583-019-0154-0DOI Listing

Taking the good with the bad.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 May;20(5):250-251

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http://dx.doi.org/10.1038/s41583-019-0159-8DOI Listing

Conversational control in singing mice.

Nat Rev Neurosci 2019 May;20(5):252

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0158-9DOI Listing

Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.

Nat Rev Neurosci 2019 Mar 15. Epub 2019 Mar 15.

GIGA-Stem Cells, University of Liège, CHU Sart Tilman, Liège, Belgium.

The cerebral cortex is an evolutionarily advanced brain structure that computes higher motor, sensory and cognitive functions. Its complex organization reflects the exquisite cell migration and differentiation patterns that take place during embryogenesis. Recent evidence supports an essential role for cell migration in shaping the developing cerebral cortex via direct cellular contacts and spatially organized diffusible cues that regulate the establishment of its cytoarchitecture and function. Read More

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http://dx.doi.org/10.1038/s41583-019-0148-yDOI Listing

A contextual binding theory of episodic memory: systems consolidation reconsidered.

Nat Rev Neurosci 2019 Mar 12. Epub 2019 Mar 12.

Center for Neuroscience, University of California, Davis, CA, USA.

Episodic memory reflects the ability to recollect the temporal and spatial context of past experiences. Episodic memories depend on the hippocampus but have been proposed to undergo rapid forgetting unless consolidated during offline periods such as sleep to neocortical areas for long-term storage. Here, we propose an alternative to this standard systems consolidation theory (SSCT) - a contextual binding account - in which the hippocampus binds item-related and context-related information. Read More

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http://www.nature.com/articles/s41583-019-0150-4
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http://dx.doi.org/10.1038/s41583-019-0150-4DOI Listing
March 2019
13 Reads

Preserving the balance: diverse forms of long-term GABAergic synaptic plasticity.

Nat Rev Neurosci 2019 May;20(5):272-281

Department of Neuroscience, Yale University, New Haven, CT, USA.

Cellular mechanisms that regulate the interplay of synaptic excitation and inhibition are thought to be central to the functional stability of healthy neuronal circuits. A growing body of literature demonstrates the capacity for inhibitory GABAergic synapses to exhibit long-term plasticity in response to changes in neuronal activity. Here, we review this expanding field of research, focusing on the diversity of mechanisms that link glutamatergic signalling, postsynaptic action potentials and inhibitory synaptic strength. Read More

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http://dx.doi.org/10.1038/s41583-019-0141-5DOI Listing
May 2019
2 Reads

Novel electrode technologies for neural recordings.

Nat Rev Neurosci 2019 Mar 4. Epub 2019 Mar 4.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Neural recording electrode technologies have contributed considerably to neuroscience by enabling the extracellular detection of low-frequency local field potential oscillations and high-frequency action potentials of single units. Nevertheless, several long-standing limitations exist, including low multiplexity, deleterious chronic immune responses and long-term recording instability. Driven by initiatives encouraging the generation of novel neurotechnologies and the maturation of technologies to fabricate high-density electronics, novel electrode technologies are emerging. Read More

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http://dx.doi.org/10.1038/s41583-019-0140-6DOI Listing
March 2019
3 Reads

Making waves with ultrasound.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr;20(4):189

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0149-xDOI Listing

Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.

Nat Rev Neurosci 2019 May;20(5):253-271

Marine Biological Laboratory, Woods Hole, MA, USA.

Electrical synapses are found in vertebrate and invertebrate nervous systems. The cellular basis of these synapses is the gap junction, a group of intercellular channels that mediate direct communication between adjacent neurons. Similar to chemical synapses, electrical connections are modifiable and their variations in strength provide a mechanism for reconfiguring neural circuits. Read More

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http://dx.doi.org/10.1038/s41583-019-0133-5DOI Listing

Parental controls.

Nat Rev Neurosci 2019 Apr;20(4):190-191

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http://dx.doi.org/10.1038/s41583-019-0147-zDOI Listing
April 2019
1 Read

Reward schemas for macaques.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr;20(4):191

Nature Reviews Neuroscience, .

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http://www.nature.com/articles/s41583-019-0145-1
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http://dx.doi.org/10.1038/s41583-019-0145-1DOI Listing
April 2019
4 Reads

REM sleep makes slow waves.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr;20(4):191

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0146-0DOI Listing
April 2019
1 Read

Overpruning in schizophrenia.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr;20(4):191

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0144-2DOI Listing
April 2019
2 Reads

A scary switch for serotonin.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Apr;20(4):191

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0143-3DOI Listing
April 2019
1 Read

Neuron-glia interactions in the pathophysiology of epilepsy.

Nat Rev Neurosci 2019 May;20(5):282-297

Fralin Biomedical Research Institute, Glial Biology in Health, Disease, and Cancer Center, Roanoke, VA, USA.

Epilepsy is a neurological disorder afflicting ~65 million people worldwide. It is caused by aberrant synchronized firing of populations of neurons primarily due to imbalance between excitatory and inhibitory neurotransmission. Hence, the historical focus of epilepsy research has been neurocentric. Read More

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http://dx.doi.org/10.1038/s41583-019-0126-4DOI Listing
May 2019
1 Read

Recalling old memories.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Apr;20(4):190-191

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0142-4DOI Listing
April 2019
1 Read

Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons.

Nat Rev Neurosci 2019 Apr;20(4):193-204

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

The mechanistic operation of brain regions is often interpreted by partitioning constituent neurons into 'cell types'. Historically, such cell types were broadly defined by their correspondence to gross features of the nervous system (such as cytoarchitecture). Modern-day neuroscientific techniques, enabling a more nuanced examination of neuronal properties, have illustrated a wealth of heterogeneity within these classical cell types. Read More

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http://dx.doi.org/10.1038/s41583-019-0125-5DOI Listing
April 2019
10 Reads

The neural mechanisms and consequences of paternal caregiving.

Nat Rev Neurosci 2019 Apr;20(4):205-224

Department of Psychology, University of Texas at Austin, Austin, TX, USA.

In recent decades, human sociocultural changes have increased the numbers of fathers that are involved in direct caregiving in Western societies. This trend has led to a resurgence of interest in understanding the mechanisms and effects of paternal care. Across the animal kingdom, paternal caregiving has been found to be a highly malleable phenomenon, presenting with great variability among and within species. Read More

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http://www.nature.com/articles/s41583-019-0124-6
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April 2019
6 Reads

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease.

Nat Rev Neurosci 2019 Mar;20(3):187

German Center for Neurodegenerative Diseases, Bonn, Germany.

In the originally published version of this article, the competing interests statement indicated that the authors had no competing interests; however, this statement was incorrect. The statement should have read as follows: 'M.H. Read More

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http://www.nature.com/articles/s41583-019-0137-1
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http://dx.doi.org/10.1038/s41583-019-0137-1DOI Listing
March 2019
12 Reads

Sat nav for the spinal cord.

Authors:
Sian Lewis

Nat Rev Neurosci 2019 Mar;20(3):130-131

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0135-3DOI Listing

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease.

Nat Rev Neurosci 2019 Mar;20(3):148-160

Department of Biochemistry and Centre for Ageing and Neurobiology, National University of Singapore, Singapore, Singapore.

Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully understand AD aetiology and pathogenesis, but oxidative damage is a key component. The brain mostly uses glucose for energy, but in AD and amnestic mild cognitive impairment glucose metabolism is dramatically decreased, probably owing, at least in part, to oxidative damage to enzymes involved in glycolysis, the tricarboxylic acid cycle and ATP biosynthesis. Read More

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http://dx.doi.org/10.1038/s41583-019-0132-6DOI Listing
March 2019
6 Reads

Revealing a receptor for secreted APP.

Authors:
Darran Yates

Nat Rev Neurosci 2019 Mar;20(3):129

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0136-2DOI Listing
March 2019
2 Reads

Environmental enrichment, new neurons and the neurobiology of individuality.

Authors:
Gerd Kempermann

Nat Rev Neurosci 2019 Apr;20(4):235-245

German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany.

'Enriched environments' are a key experimental paradigm to decipher how interactions between genes and environment change the structure and function of the brain across the lifespan of an animal. The regulation of adult hippocampal neurogenesis by environmental enrichment is a prime example of this complex interaction. As each animal in an enriched environment will have a slightly different set of experiences that results in downstream differences between individuals, enrichment can be considered not only as an external source of rich stimuli but also to provide the room for individual behaviour that shapes individual patterns of brain plasticity and thus function. Read More

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http://dx.doi.org/10.1038/s41583-019-0120-xDOI Listing
April 2019
1 Read

Affective valence in the brain: modules or modes?

Authors:
Kent C Berridge

Nat Rev Neurosci 2019 Apr;20(4):225-234

Department of Psychology, University of Michigan, Ann Arbor, MI, USA.

How do brain systems evaluate the affective valence of a stimulus - that is, its quality of being good or bad? One possibility is that a neural subsystem, or 'module' (such as a subregion of the brain, a projection pathway, a neuronal population or an individual neuron), is permanently dedicated to mediate only one affective function, or at least only one specific valence - an idea that is termed here the 'affective modules' hypothesis. An alternative possibility is that a given neural module can exist in multiple neurobiological states that give it different affective functions - an idea termed here the 'affective modes' hypothesis. This suggests that the affective function or valence mediated by a neural module need not remain permanently stable but rather can change dynamically across different situations. Read More

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http://dx.doi.org/10.1038/s41583-019-0122-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426670PMC
April 2019
1 Read

Lost in ruptures.

Authors:
Natasha Bray

Nat Rev Neurosci 2019 Mar;20(3):132

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http://dx.doi.org/10.1038/s41583-019-0134-4DOI Listing
March 2019
1 Read

Balancing competing drives.

Nat Rev Neurosci 2019 Mar;20(3):132

Nature Reviews Neuroscience, .

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http://dx.doi.org/10.1038/s41583-019-0127-3DOI Listing
March 2019
1 Read