1,750 results match your criteria Nature Reviews Nephrology[Journal]


Modelling diabetic vasculopathy with human vessel organoids.

Authors:
Ryuji Morizane

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Renal Division, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41581-019-0125-8DOI Listing
February 2019

Growing mouse kidneys in rats.

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0127-6DOI Listing
February 2019

Fluid flow enhances vascularization and maturation of kidney organoids.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0126-7DOI Listing
February 2019

Cyclin G1 drives maladaptive renal repair.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0124-9DOI Listing
February 2019

Albuminuria: a target for clinical trials in kidney disease?

Nat Rev Nephrol 2019 Feb 14. Epub 2019 Feb 14.

Geffen School of Medicine, UCLA, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41581-019-0123-xDOI Listing
February 2019

Some nephron progenitors fail to commit.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0122-yDOI Listing
February 2019

Cellular signalling by primary cilia in development, organ function and disease.

Nat Rev Nephrol 2019 Feb 7. Epub 2019 Feb 7.

Department of Biology, Section of Cell Biology and Physiology, University of Copenhagen, Copenhagen, Denmark.

Primary cilia project in a single copy from the surface of most vertebrate cell types; they detect and transmit extracellular cues to regulate diverse cellular processes during development and to maintain tissue homeostasis. The sensory capacity of primary cilia relies on the coordinated trafficking and temporal localization of specific receptors and associated signal transduction modules in the cilium. The canonical Hedgehog (HH) pathway, for example, is a bona fide ciliary signalling system that regulates cell fate and self-renewal in development and tissue homeostasis. Read More

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http://www.nature.com/articles/s41581-019-0116-9
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February 2019
6 Reads

Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Nat Rev Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

Uraemic syndrome (also known as uremic syndrome) in patients with advanced chronic kidney disease involves the accumulation in plasma of small-molecule uraemic solutes and uraemic toxins (also known as uremic toxins), dysfunction of multiple organs and dysbiosis of the gut microbiota. As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple biological pathways are affected, including those controlled by solute carrier (SLC) and ATP-binding cassette (ABC) transporters and drug-metabolizing enzymes, many of which are also involved in drug absorption, distribution, metabolism and elimination (ADME). Read More

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http://dx.doi.org/10.1038/s41581-019-0111-1DOI Listing
February 2019
2 Reads

Kidney disease in the Global Burden of Disease Study 2017.

Nat Rev Nephrol 2019 Feb 5. Epub 2019 Feb 5.

School of Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1038/s41581-019-0120-0DOI Listing
February 2019

The genetic changes of Wilms tumour.

Nat Rev Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Wellcome Sanger Institute, Cambridge, UK.

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in the majority of cases, albeit at considerable cost in terms of late treatment-related effects in some children. However, one in ten children with Wilms tumour will die of their disease despite modern treatment approaches. Read More

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http://dx.doi.org/10.1038/s41581-019-0112-0DOI Listing
January 2019

Macrophages: versatile players in renal inflammation and fibrosis.

Nat Rev Nephrol 2019 Mar 28;15(3):144-158. Epub 2019 Jan 28.

Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Lui Che Woo Institute of Innovative Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Macrophages have important roles in immune surveillance and in the maintenance of kidney homeostasis; their response to renal injury varies enormously depending on the nature and duration of the insult. Macrophages can adopt a variety of phenotypes: at one extreme, M1 pro-inflammatory cells contribute to infection clearance but can also promote renal injury; at the other extreme, M2 anti-inflammatory cells have a reparative phenotype and can contribute to the resolution phase of the response to injury. In addition, bone marrow monocytes can differentiate into myeloid-derived suppressor cells that can regulate T cell immunity in the kidney. Read More

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http://dx.doi.org/10.1038/s41581-019-0110-2DOI Listing

C3 glomerulopathy - understanding a rare complement-driven renal disease.

Nat Rev Nephrol 2019 Mar;15(3):129-143

Molecular Otolaryngology and Renal Research Laboratories and the Departments of Internal Medicine and Pediatrics (Divisions of Nephrology), Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposition in kidney biopsy samples. The two major subgroups of C3 glomerulopathy - dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) - have overlapping clinical and pathological features suggestive of a disease continuum. Dysregulation of the complement alternative pathway is fundamental to the manifestations of C3 glomerulopathy, although terminal pathway dysregulation is also common. Read More

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http://www.nature.com/articles/s41581-018-0107-2
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March 2019
11 Reads
8.542 Impact Factor

Nitric oxide protects against AKI by reprogramming metabolism.

Nat Rev Nephrol 2019 Jan 24. Epub 2019 Jan 24.

Service and Laboratory of Nephrology, Department of Medicine, University and University Hospital of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41581-019-0113-zDOI Listing
January 2019

The genetic architecture of blood pressure.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0117-8DOI Listing
January 2019
1 Read

DNA methylation links intrauterine stress with abnormal nephrogenesis.

Authors:
Samir S El-Dahr

Nat Rev Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/s41581-019-0114-yDOI Listing
January 2019
1 Read

CNVs in CAKUT.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-019-0115-xDOI Listing
January 2019
1 Read

Evolving concepts in the pathogenesis of uraemic cardiomyopathy.

Nat Rev Nephrol 2019 Mar;15(3):159-175

Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.

The term uraemic cardiomyopathy refers to the cardiac abnormalities that are seen in patients with chronic kidney disease (CKD). Historically, this term was used to describe a severe cardiomyopathy that was associated with end-stage renal disease and characterized by severe functional abnormalities that could be reversed following renal transplantation. In a modern context, uraemic cardiomyopathy describes the clinical phenotype of cardiac disease that accompanies CKD and is perhaps best characterized as diastolic dysfunction seen in conjunction with left ventricular hypertrophy and fibrosis. Read More

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http://www.nature.com/articles/s41581-018-0101-8
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March 2019
5 Reads

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications.

Nat Rev Nephrol 2019 Jan 16. Epub 2019 Jan 16.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University and Charlie Norwood VA Medical Center, Augusta, GA, USA.

Acute kidney injury (AKI) is a major public health concern associated with high morbidity and mortality. Despite decades of research, the pathogenesis of AKI remains incompletely understood and effective therapies are lacking. An increasing body of evidence suggests a role for epigenetic regulation in the process of AKI and kidney repair, involving remarkable changes in histone modifications, DNA methylation and the expression of various non-coding RNAs. Read More

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http://dx.doi.org/10.1038/s41581-018-0103-6DOI Listing
January 2019
2 Reads

Local solutions save young lives.

Authors:
Simon J Davies

Nat Rev Nephrol 2019 Mar;15(3):127-128

Faculty of Medicine and Health Sciences, Keele University, Keele, Staffordshire, UK.

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http://dx.doi.org/10.1038/s41581-018-0109-0DOI Listing
March 2019
1 Read
8.542 Impact Factor

Endothelium structure and function in kidney health and disease.

Nat Rev Nephrol 2019 Feb;15(2):87-108

INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006, Paris, France.

The kidney harbours different types of endothelia, each with specific structural and functional characteristics. The glomerular endothelium, which is highly fenestrated and covered by a rich glycocalyx, participates in the sieving properties of the glomerular filtration barrier and in the maintenance of podocyte structure. The microvascular endothelium in peritubular capillaries, which is also fenestrated, transports reabsorbed components and participates in epithelial cell function. Read More

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http://dx.doi.org/10.1038/s41581-018-0098-zDOI Listing
February 2019
3 Reads

Progress in the understanding of polycystic kidney disease.

Nat Rev Nephrol 2019 Feb;15(2):70-72

Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41581-018-0108-1DOI Listing
February 2019
4 Reads

Sodium transport in diabetes: two sides to the coin.

Nat Rev Nephrol 2019 Mar;15(3):125-126

Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://www.nature.com/articles/s41581-018-0106-3
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March 2019
3 Reads

Single-cell genomics and gene editing: implications for nephrology.

Nat Rev Nephrol 2019 Feb;15(2):63-64

Division of Nephrology, Department of Medicine, Washington University in Saint Louis School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1038/s41581-018-0094-3DOI Listing
February 2019
1 Read

Sepsis halts renal protein translation.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Mar;15(3):124

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0104-5DOI Listing
March 2019
1 Read

Author Correction: Estimated GFR: time for a critical appraisal.

Nat Rev Nephrol 2019 Feb;15(2):121

Nephrology and Dialysis Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

In the version of this article originally published online, the middle initials of Aiko P. J. de Vries, an author on the manuscript, were omitted. Read More

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http://www.nature.com/articles/s41581-018-0105-4
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February 2019
8 Reads

Protecting the kidney against autoimmunity and inflammation.

Nat Rev Nephrol 2019 Feb;15(2):66-68

Institute of Cellular and Integrative Physiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1038/s41581-018-0097-0DOI Listing
February 2019
1 Read

The handwriting is on the wall: there will soon be a drug for AKI.

Nat Rev Nephrol 2019 Feb;15(2):65-66

Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1038/s41581-018-0095-2DOI Listing
February 2019
1 Read

ARP3 in podocyte development.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Mar;15(3):124

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0100-9DOI Listing
March 2019
1 Read

Author Correction: Lipid management in patients with chronic kidney disease.

Nat Rev Nephrol 2019 Feb;15(2):121

CNR- IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases, Ospedali Riuniti, Italy.

In the acknowledgements section of this article as originally published, information on the authors' roles as EURECAm members is missing. The correct acknowledgement is as follows: "This Review was planned as part of the activity of the European Renal and Cardiovascular Medicine working (EURECAm) group and all authors are EURECAm members. A. Read More

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http://dx.doi.org/10.1038/s41581-018-0099-yDOI Listing
February 2019
3 Reads

A promising outlook for diabetic kidney disease.

Nat Rev Nephrol 2019 Feb;15(2):68-70

Department of Endocrinology and Diabetes, The Alfred Hospital, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1038/s41581-018-0092-5DOI Listing
February 2019
2 Reads

A CD4 T cell population provides B cell help in systemic lupus erythematosus.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Mar;15(3):123

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0096-1DOI Listing
March 2019
2 Reads

Estimated GFR: time for a critical appraisal.

Nat Rev Nephrol 2019 Mar;15(3):177-190

Nephrology and Dialysis Unit, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Since 1957, over 70 equations based on creatinine and/or cystatin C levels have been developed to estimate glomerular filtration rate (GFR). However, whether these equations accurately reflect renal function is debated. In this Perspectives article, we discuss >70 studies that compared estimated GFR (eGFR) with measured GFR (mGFR), involving ~40,000 renal transplant recipients and patients with chronic kidney disease (CKD), type 2 diabetes mellitus or polycystic kidney disease. Read More

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http://dx.doi.org/10.1038/s41581-018-0080-9DOI Listing
March 2019
7 Reads

Renal and extrarenal effects of fibroblast growth factor 23.

Authors:
Marc Vervloet

Nat Rev Nephrol 2019 Feb;15(2):109-120

Amsterdam Cardiovascular Sciences and Department of Nephrology, Amsterdam University Medical Center, Amsterdam, Netherlands.

Fibroblast growth factor 23 (FGF23) is a hormone with a central role in the regulation of phosphate homeostasis. This regulation is accomplished by the coordinated modulation of renal phosphate handling, vitamin D metabolism and parathyroid hormone secretion. Patients with kidney disease have increased circulating levels of FGF23 and in other patient populations and in healthy individuals, FGF23 levels also rise following an increase in dietary phosphate intake. Read More

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http://dx.doi.org/10.1038/s41581-018-0087-2DOI Listing
February 2019
4 Reads

Transcriptional programmes of kidney injury.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Mar;15(3):124

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0091-6DOI Listing
March 2019
2 Reads

A novel RNA interference approach to targeting sFLT1 in pre-eclampsia.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Feb;15(2):62

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0093-4DOI Listing
February 2019
7 Reads

DNA origami scavenges ROS in the kidney.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Feb;15(2):61

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0090-7DOI Listing
February 2019
16 Reads

Glomerular and tubulointerstitial eQTLs for genomic discovery.

Nat Rev Nephrol 2019 Jan;15(1):3-4

Department of Pediatrics-Nephrology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/s41581-018-0089-0DOI Listing
January 2019
1 Read

IDEAL timing of renal replacement therapy in critical care.

Nat Rev Nephrol 2019 Jan;15(1):5-6

Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1038/s41581-018-0088-1DOI Listing
January 2019
1 Read
8.542 Impact Factor

The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

Nat Rev Nephrol 2019 Jan;15(1):45-59

Division of Nephrology, Hematology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

The term monoclonal gammopathy of renal significance (MGRS) was introduced by the International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012. The IKMG met in April 2017 to refine the definition of MGRS and to update the diagnostic criteria for MGRS-related diseases. Accordingly, in this Expert Consensus Document, the IKMG redefines MGRS as a clonal proliferative disorder that produces a nephrotoxic monoclonal immunoglobulin and does not meet previously defined haematological criteria for treatment of a specific malignancy. Read More

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http://dx.doi.org/10.1038/s41581-018-0077-4DOI Listing
January 2019
2 Reads

The Klotho proteins in health and disease.

Authors:
Makoto Kuro-O

Nat Rev Nephrol 2019 Jan;15(1):27-44

Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.

The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho-FGFR4 complex in hepatocytes to promote metabolic responses to feeding. Read More

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http://dx.doi.org/10.1038/s41581-018-0078-3DOI Listing
January 2019
26 Reads

Hepatitis C virus and the kidney.

Nat Rev Nephrol 2019 Feb;15(2):73-86

Department of Nephrology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

Hepatitis C virus (HCV) infection is more prevalent and is associated with higher mortality in patients receiving dialysis and in kidney transplant recipients than in the general population. Kidney transplant recipients who are HCV-positive are also at higher risk of allograft and liver failure than are HCV-negative recipients. Moreover, HCV infection is associated with a higher incidence and faster progression of diabetes mellitus and chronic kidney disease (CKD), as well as a higher incidence of systemic (especially cardiovascular) complications. Read More

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http://www.nature.com/articles/s41581-018-0081-8
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http://dx.doi.org/10.1038/s41581-018-0081-8DOI Listing
February 2019
23 Reads

Effector and regulatory B cells in immune-mediated kidney disease.

Nat Rev Nephrol 2019 Jan;15(1):11-26

UCL Centre for Nephrology, Royal Free Hospital, London, UK.

B cells have a central role in many autoimmune diseases, including in those with renal involvement, as well as in the immunological response to kidney transplantation. The majority of B cell studies have focused on their pathological role as antibody producers. However, these cells have broad functions in immune responses beyond immunoglobulin secretion, including antigen presentation to T cells and cytokine production. Read More

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http://www.nature.com/articles/s41581-018-0074-7
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January 2019
16 Reads

Targeting NAD synthesis to boost mitochondrial function and protect the kidney.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Jan;15(1)

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0086-3DOI Listing
January 2019
1 Read

ALMS1-NKCC2 interactions.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Feb;15(2):62

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0084-5DOI Listing
February 2019
1 Read

PIEZOs in baroreceptor reflex.

Authors:
Susan J Allison

Nat Rev Nephrol 2019 Feb;15(2):62

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0085-4DOI Listing
February 2019
1 Read

A central anti-oncogenic pathway in ccRCC.

Authors:
Monica Wang

Nat Rev Nephrol 2019 Jan;15(1)

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0083-6DOI Listing
January 2019
1 Read

CXCL12 limits podocyte regeneration.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Jan;15(1)

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0082-7DOI Listing
January 2019
1 Read

The multifaceted role of complement in kidney transplantation.

Nat Rev Nephrol 2018 Dec;14(12):767-781

Department of Immunology, Genetics and Pathology (IGP), Rudbeck Laboratory C5:3, Uppsala University, Uppsala, Sweden.

Increasing evidence indicates an integral role for the complement system in the deleterious inflammatory reactions that occur during critical phases of the transplantation process, such as brain or cardiac death of the donor, surgical trauma, organ preservation and ischaemia-reperfusion injury, as well as in humoral and cellular immune responses to the allograft. Ischaemia is the most common cause of complement activation in kidney transplantation and in combination with reperfusion is a major cause of inflammation and graft damage. Complement also has a prominent role in antibody-mediated rejection (ABMR) owing to ABO and HLA incompatibility, which leads to devastating damage to the transplanted kidney. Read More

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http://www.nature.com/articles/s41581-018-0071-x
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December 2018
3 Reads

Endocytosis in the proximal tubule.

Authors:
Ellen F Carney

Nat Rev Nephrol 2019 Jan;15(1)

Nature Reviews Nephrology, .

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http://dx.doi.org/10.1038/s41581-018-0079-2DOI Listing
January 2019
3 Reads