2,231 results match your criteria Nature Reviews Molecular Cell Biology [Journal]


Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function.

Nat Rev Mol Cell Biol 2019 Feb 19. Epub 2019 Feb 19.

Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

Figure 2 of the article as originally published contained a graphic editing error, whereby the publisher's redrawn figure wrongly indicated the presence of a Drosophila melanogaster orthologue of ZUP1. This has been corrected in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41580-019-0112-8DOI Listing
February 2019

The unusual SASPects.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Feb 15. Epub 2019 Feb 15.

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0111-9DOI Listing
February 2019

May the force be with your lipids.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2019 Feb 13. Epub 2019 Feb 13.

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0109-3DOI Listing
February 2019

Haematopoietic stem cell activity and interactions with the niche.

Nat Rev Mol Cell Biol 2019 Feb 11. Epub 2019 Feb 11.

Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, NY, USA.

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal, differentiation and migration of HSCs and progenitor cells at steady state and in response to emergencies and injury. Improved methods for HSC isolation, driven by advances in single-cell and molecular technologies, have led to a better understanding of their behaviour, heterogeneity and lineage fate and of the niche cells and signals that regulate their function. Niche regulatory signals can be in the form of cell-bound or secreted factors and other local physical cues. Read More

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http://www.nature.com/articles/s41580-019-0103-9
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http://dx.doi.org/10.1038/s41580-019-0103-9DOI Listing
February 2019
1 Read

Breaking the chains: deubiquitylating enzyme specificity begets function.

Nat Rev Mol Cell Biol 2019 Feb 7. Epub 2019 Feb 7.

Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases) maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from proteins. In light of the many cellular functions of ubiquitin, DUBs occupy key roles in almost all aspects of cell behaviour. Many DUBs show selectivity for particular ubiquitin linkage types or positions within ubiquitin chains. Read More

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http://dx.doi.org/10.1038/s41580-019-0099-1DOI Listing
February 2019

Detouring the roadblocks in gene expression.

Nat Rev Mol Cell Biol 2019 Feb 7. Epub 2019 Feb 7.

Max Delbruck Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin, Germany.

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http://dx.doi.org/10.1038/s41580-019-0107-5DOI Listing
February 2019

The proteostasis network and its decline in ageing.

Nat Rev Mol Cell Biol 2019 Feb 7. Epub 2019 Feb 7.

Max Planck Institute of Biochemistry, Department of Cellular Biochemistry, Martinsried, Germany.

Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark of many age-related diseases is the dysfunction in protein homeostasis (proteostasis), leading to the accumulation of protein aggregates. In healthy cells, a complex proteostasis network, comprising molecular chaperones and proteolytic machineries and their regulators, operates to ensure the maintenance of proteostasis. Read More

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http://dx.doi.org/10.1038/s41580-019-0101-yDOI Listing
February 2019
1 Read

Publisher Correction: Regulation of microRNA biogenesis and its crosstalk with other cellular pathways.

Nat Rev Mol Cell Biol 2019 Feb 6. Epub 2019 Feb 6.

Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany.

The legend of Figure 2 neglected to acknowledge that part b was adapted with permission from ref., Elsevier and that part d, third panel from the left was reproduced from ref., Springer Nature Limited. Read More

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http://dx.doi.org/10.1038/s41580-019-0106-6DOI Listing
February 2019

Forcing through barriers.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Mar;20(3):136

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0104-8DOI Listing

Telomere crisis activates autophagic death.

Nat Rev Mol Cell Biol 2019 Mar;20(3):133

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0105-7DOI Listing

How cells keep scale.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Mar;20(3):136

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0102-xDOI Listing

Spatial proteomics: a powerful discovery tool for cell biology.

Nat Rev Mol Cell Biol 2019 Jan 18. Epub 2019 Jan 18.

Max Planck Institute of Biochemistry, Department of Proteomics and Signal Transduction, Martinsried, Germany.

Protein subcellular localization is tightly controlled and intimately linked to protein function in health and disease. Capturing the spatial proteome - that is, the localizations of proteins and their dynamics at the subcellular level - is therefore essential for a complete understanding of cell biology. Owing to substantial advances in microscopy, mass spectrometry and machine learning applications for data analysis, the field is now mature for proteome-wide investigations of spatial cellular regulation. Read More

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http://www.nature.com/articles/s41580-018-0094-y
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January 2019
10 Reads

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.

Nat Rev Mol Cell Biol 2019 Mar;20(3):175-193

John B. Little Center for Radiation Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including neurological and infectious diseases as well as environmental and medical toxicities. Conversely, the abnormal survival and accumulation of damaged or superfluous cells drive prominent human pathologies such as cancers and autoimmune diseases. Apoptosis is an evolutionarily conserved cell death pathway that is responsible for the programmed culling of cells during normal eukaryotic development and maintenance of organismal homeostasis. Read More

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http://dx.doi.org/10.1038/s41580-018-0089-8DOI Listing
March 2019
1 Read

Enhancers and promoters regulate burst kinetics.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2019 Mar;20(3):134-135

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-019-0100-zDOI Listing
March 2019
1 Read

Crosstalk between metabolism and circadian clocks.

Nat Rev Mol Cell Biol 2019 Jan 11. Epub 2019 Jan 11.

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest (sleep) phases that differ largely in their metabolic requirements. The circadian clock evolved as an autonomous timekeeping system that aligns behavioural patterns with the solar day and supports the body functions by anticipating and coordinating the required metabolic programmes. The key component of this synchronization is a master clock in the brain, which responds to light-darkness cues from the environment. Read More

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http://dx.doi.org/10.1038/s41580-018-0096-9DOI Listing
January 2019
2 Reads

Mitochondrial proteins: from biogenesis to functional networks.

Nat Rev Mol Cell Biol 2019 Jan 9. Epub 2019 Jan 9.

Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial functions in bioenergetics, metabolism and signalling and have been associated with numerous diseases. Recent functional and proteomic studies have revealed the remarkable complexity of mitochondrial protein organization. Protein machineries with diverse functions such as protein translocation, respiration, metabolite transport, protein quality control and the control of membrane architecture interact with each other in dynamic networks. Read More

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http://dx.doi.org/10.1038/s41580-018-0092-0DOI Listing
January 2019
2 Reads

Adipogenesis and metabolic health.

Nat Rev Mol Cell Biol 2019 Jan 4. Epub 2019 Jan 4.

Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). Read More

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http://dx.doi.org/10.1038/s41580-018-0093-zDOI Listing
January 2019
2 Reads

Lipid give and take.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2019 Mar;20(3):134-135

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0098-7DOI Listing
March 2019
1 Read

Freedom of expression in methylated regions.

Nat Rev Mol Cell Biol 2019 Feb;20(2):66-67

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0097-8DOI Listing
February 2019
2 Reads

Mitochondria unite.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Feb;20(2):65

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0095-xDOI Listing
February 2019
1 Read

Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine.

Nat Rev Mol Cell Biol 2018 Dec 13. Epub 2018 Dec 13.

VIB Center for Cancer Biology, and KU Leuven Department of Oncology, University of Leuven, Leuven, Belgium.

The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and regeneration. Remarkably, experimental activation of YAP/TAZ in the mouse can promote regeneration in organs with poor or compromised regenerative capacity, such as the adult heart and the liver and intestine of old or diseased mice. However, therapeutic YAP/TAZ activation may cause serious side effects. Read More

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http://dx.doi.org/10.1038/s41580-018-0086-yDOI Listing
December 2018
1 Read

Dynamics and functions of lipid droplets.

Nat Rev Mol Cell Biol 2019 Mar;20(3):137-155

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They have a unique architecture consisting of a hydrophobic core of neutral lipids, which is enclosed by a phospholipid monolayer that is decorated by a specific set of proteins. Originating from the endoplasmic reticulum, lipid droplets can associate with most other cellular organelles through membrane contact sites. Read More

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http://dx.doi.org/10.1038/s41580-018-0085-zDOI Listing
March 2019
1 Read

6mA in stress tolerance across generations.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2019 Feb;20(2):66-67

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0091-1DOI Listing
February 2019
1 Read

Guardians of the oocyte methylome.

Authors:
Kim Baumann

Nat Rev Mol Cell Biol 2019 Jan;20(1):2-3

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0090-2DOI Listing
January 2019
3 Reads

A MAD way to regulate mitosis.

Authors:
David Barford

Nat Rev Mol Cell Biol 2019 Mar;20(3):135

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.1038/s41580-018-0084-0DOI Listing
March 2019
2 Reads

Sorting it out at the Golgi.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Jan;20(1):2-3

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0087-xDOI Listing
January 2019
1 Read

Protein trafficking through TIGER domains.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2019 Jan;20(1)

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0088-9DOI Listing
January 2019
2 Reads

Ribosome assembly coming into focus.

Nat Rev Mol Cell Biol 2019 Feb;20(2):116-131

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have identified most of the factors that participate in this complex pathway and have generated models for the mechanisms driving the assembly. More recently, the publication of numerous cryo-electron microscopy structures of yeast ribosome assembly intermediates has provided near-atomic resolution snapshots of ribosome precursor particles. Satisfyingly, these structural data support the genetic and biochemical models and provide additional mechanistic insight into ribosome assembly. Read More

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http://www.nature.com/articles/s41580-018-0078-y
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February 2019
3 Reads

Functions and mechanisms of non-histone protein acetylation.

Nat Rev Mol Cell Biol 2019 Mar;20(3):156-174

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Nε-lysine acetylation was discovered more than half a century ago as a post-translational modification of histones and has been extensively studied in the context of transcription regulation. In the past decade, proteomic analyses have revealed that non-histone proteins are frequently acetylated and constitute a major portion of the acetylome in mammalian cells. Indeed, non-histone protein acetylation is involved in key cellular processes relevant to physiology and disease, such as gene transcription, DNA damage repair, cell division, signal transduction, protein folding, autophagy and metabolism. Read More

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http://dx.doi.org/10.1038/s41580-018-0081-3DOI Listing
March 2019
54 Reads

New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.

Nat Rev Mol Cell Biol 2019 Feb;20(2):69-84

Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

Epithelial-mesenchymal transition (EMT) is a cellular programme that is known to be crucial for embryogenesis, wound healing and malignant progression. During EMT, cell-cell and cell-extracellular matrix interactions are remodelled, which leads to the detachment of epithelial cells from each other and the underlying basement membrane, and a new transcriptional programme is activated to promote the mesenchymal fate. In the context of neoplasias, EMT confers on cancer cells increased tumour-initiating and metastatic potential and a greater resistance to elimination by several therapeutic regimens. Read More

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http://dx.doi.org/10.1038/s41580-018-0080-4DOI Listing
February 2019
7 Reads

Neurodegenerative polyglutamylation.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2019 Jan;20(1)

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0083-1DOI Listing
January 2019
2 Reads

Functions and mechanisms of epigenetic inheritance in animals.

Nat Rev Mol Cell Biol 2018 Dec;19(12):774-790

Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

The idea that epigenetic determinants such as DNA methylation, histone modifications or RNA can be passed to the next generation through meiotic products (gametes) is long standing. Such meiotic epigenetic inheritance (MEI) is fairly common in yeast, plants and nematodes, but its extent in mammals has been much debated. Advances in genomics techniques are now driving the profiling of germline and zygotic epigenomes, thereby improving our understanding of MEI in diverse species. Read More

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http://www.nature.com/articles/s41580-018-0074-2
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December 2018
25 Reads

150 years of Darwin's theory of intercellular flow of hereditary information.

Nat Rev Mol Cell Biol 2018 Dec;19(12):749-750

Department of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV, USA.

Charles Darwin's Pangenesis theory, which proposed an intercellular mechanism for the flow of hereditary information, is gaining new ground. Read More

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http://dx.doi.org/10.1038/s41580-018-0072-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309184PMC
December 2018
2 Reads
36.458 Impact Factor

A changing paradigm of transcriptional memory propagation through mitosis.

Nat Rev Mol Cell Biol 2019 Jan;20(1):55-64

Institute for Regenerative Medicine, Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Smilow Center for Translational Research, Philadelphia, PA, USA.

The highly reproducible inheritance of chromosomes during mitosis in mammalian cells involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range intrachromosomal interactions, loss of enhancer-promoter proximity, displacement of many transcription regulators from the chromatin and a marked decrease in RNA synthesis. Despite these dramatic changes in the mother cell, daughter cells are able to faithfully re-establish the parental chromatin and gene expression features characteristic of the cell type. Pioneering studies of mitotic chromatin signatures showed that despite global repression of transcription, the Hsp70 gene promoter retains an open chromatin conformation, which was proposed to allow the reactivation of the Hsp70 gene upon completion of mitosis - a phenomenon termed mitotic bookmarking. Read More

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http://dx.doi.org/10.1038/s41580-018-0077-zDOI Listing
January 2019
2 Reads

Integrative regulation of physiology by histone deacetylase 3.

Nat Rev Mol Cell Biol 2019 Feb;20(2):102-115

Institute for Diabetes, Obesity, and Metabolism, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Cell-type-specific gene expression is physiologically modulated by the binding of transcription factors to genomic enhancer sequences, to which chromatin modifiers such as histone deacetylases (HDACs) are recruited. Drugs that inhibit HDACs are in clinical use but lack specificity. HDAC3 is a stoichiometric component of nuclear receptor co-repressor complexes whose enzymatic activity depends on this interaction. Read More

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http://www.nature.com/articles/s41580-018-0076-0
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347506PMC
February 2019
9 Reads

Inhibition by nuclear cGAS.

Authors:
Grant Otto

Nat Rev Mol Cell Biol 2018 Dec;19(12):752-753

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0082-2DOI Listing
December 2018
1 Read

Myc in elongation and repression.

Nat Rev Mol Cell Biol 2018 Dec;19(12):751

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0079-xDOI Listing
December 2018
2 Reads

Publisher Correction: Post-transcriptional gene regulation by mRNA modifications.

Nat Rev Mol Cell Biol 2018 Dec;19(12):808

Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois, 60637, USA.

In Figure 5, translation initiation is promoted not by the indicated protein, but by YTHDF1 (see below). Read More

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http://dx.doi.org/10.1038/s41580-018-0075-1DOI Listing
December 2018
1 Read

PrEView of cell-cell communication.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2018 Dec;19(12):752-753

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0073-3DOI Listing
December 2018
2 Reads

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes.

Nat Rev Mol Cell Biol 2019 Feb;20(2):85-101

Institute of Ophthalmology, University College London, London, UK.

Lipids are distributed in a highly heterogeneous fashion in different cellular membranes. Only a minority of lipids achieve their final intracellular distribution through transport by vesicles. Instead, the bulk of lipid traffic is mediated by a large group of lipid transfer proteins (LTPs), which move small numbers of lipids at a time using hydrophobic cavities that stabilize lipid molecules outside membranes. Read More

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http://dx.doi.org/10.1038/s41580-018-0071-5DOI Listing
February 2019
2 Reads

Actin-microtubule crosstalk in cell biology.

Nat Rev Mol Cell Biol 2019 Jan;20(1):38-54

AMOLF, Living Matter Department, Amsterdam, Netherlands.

The cytoskeleton and its components - actin, microtubules and intermediate filaments - have been studied for decades, and multiple roles of the individual cytoskeletal substructures are now well established. However, in recent years it has become apparent that the three cytoskeletal elements also engage in extensive crosstalk that is important for core biological processes. Actin-microtubule crosstalk is particularly important for the regulation of cell shape and polarity during cell migration and division and the establishment of neuronal and epithelial cell shape and function. Read More

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http://dx.doi.org/10.1038/s41580-018-0067-1DOI Listing
January 2019
2 Reads

Linking cellular stress responses to systemic homeostasis.

Nat Rev Mol Cell Biol 2018 Nov;19(11):731-745

Université Paris Descartes/Paris V, Paris, France.

Mammalian cells respond to stress by activating mechanisms that support cellular functions and hence maintain microenvironmental and organismal homeostasis. Intracellular responses to stress, their regulation and their pathophysiological implications have been extensively studied. However, little is known about the signals that emanate from stressed cells to enable a coordinated adaptive response across tissues, organs and the whole organism. Read More

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http://dx.doi.org/10.1038/s41580-018-0068-0DOI Listing
November 2018
6 Reads

'Forward genetics' and the causes of ALS.

Authors:
Adriano Aguzzi

Nat Rev Mol Cell Biol 2019 Feb;20(2):67

Institute of Neuropathology, University of Zurich,, CH-8002, Zurich, Switzerland.

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http://dx.doi.org/10.1038/s41580-018-0062-6DOI Listing
February 2019
11 Reads

Author Correction: Regulation of microRNA biogenesis and its crosstalk with other cellular pathways.

Nat Rev Mol Cell Biol 2018 Dec;19(12):808

Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany.

In Figure 1b, the GHG sequence motif in the primary microRNA has been moved to the basal stem and the ruler of the basal stem has been shortened to more precisely delineate 11 base pairs. The changes have been made in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41580-018-0070-6DOI Listing
December 2018
3 Reads

Transcriptionally tailored break repair.

Nat Rev Mol Cell Biol 2018 Nov;19(11):675

Nature Reviews Molecular Cell Biology, .

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http://dx.doi.org/10.1038/s41580-018-0069-zDOI Listing
November 2018
3 Reads

Publisher Correction: The machineries, regulation and cellular functions of mitochondrial calcium.

Nat Rev Mol Cell Biol 2018 Nov;19(11):746

Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA, University of Ferrara, Ferrara, Italy.

In the original version of the article, sentences highlighting references 108, 137 and 175 incorrectly refer to other items in the reference list: reference 106, 132 and 169, respectively, which were corrected - in order - to reference 110, 136 and 176. The changes have been made in the HTML and PDF versions of the manuscript. Read More

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http://dx.doi.org/10.1038/s41580-018-0066-2DOI Listing
November 2018
1 Read

A new era for understanding amyloid structures and disease.

Nat Rev Mol Cell Biol 2018 Dec;19(12):755-773

Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition of amyloid fibrils, collectively known as amyloidosis, is associated with many pathological conditions that can be associated with ageing, such as Alzheimer disease, Parkinson disease, type II diabetes and dialysis-related amyloidosis. However, elucidation of the atomic structure of amyloid fibrils formed from their intact protein precursors and how fibril formation relates to disease has remained elusive. Read More

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http://www.nature.com/articles/s41580-018-0060-8
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December 2018
29 Reads

HATs off for the Lasker awardees.

Authors:
Paulina Strzyz

Nat Rev Mol Cell Biol 2018 Nov;19(11):677

Nature Reviews Molecular Cell Biology, .

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http://www.nature.com/articles/s41580-018-0065-3
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http://dx.doi.org/10.1038/s41580-018-0065-3DOI Listing
November 2018
2 Reads

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways.

Nat Rev Mol Cell Biol 2019 Jan;20(1):5-20

Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Regensburg, Germany.

MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which are subsequently cleaved by the endoribonucleases Drosha and Dicer. Mature miRNAs are bound by a member of the Argonaute (AGO) protein family to form the RNA-induced silencing complex (RISC) in a process termed RISC loading. Read More

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http://www.nature.com/articles/s41580-018-0059-1
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http://dx.doi.org/10.1038/s41580-018-0059-1DOI Listing
January 2019
22 Reads

The (chain) terminators.

Nat Rev Mol Cell Biol 2019 Jan;20(1)

Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41580-018-0063-5
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http://dx.doi.org/10.1038/s41580-018-0063-5DOI Listing
January 2019
4 Reads