2,117 results match your criteria Nature Reviews Immunology [Journal]


Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Nat Rev Immunol 2019 Feb 15. Epub 2019 Feb 15.

Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0131-xDOI Listing
February 2019

Pain killers.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb 7. Epub 2019 Feb 7.

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0137-4DOI Listing
February 2019

T cells feel the heat.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Feb 6. Epub 2019 Feb 6.

Nature Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0134-7DOI Listing
February 2019
1 Read

Sleeping off sickness.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-019-0136-5
Publisher Site
http://dx.doi.org/10.1038/s41577-019-0136-5DOI Listing
February 2019
2 Reads

Gut IELs slow metabolism.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0133-8DOI Listing
February 2019
1 Read

Butyrate boosts microbicidal macrophages.

Nat Rev Immunol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0132-9DOI Listing
February 2019

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The environment, diet, microbiota and body's metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0125-8DOI Listing
February 2019
1 Read

Macrophages as regulators of tumour immunity and immunotherapy.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Department of Immunology, Department of Breast Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0127-6DOI Listing
February 2019

Breaking the law: unconventional strategies for antibody diversification.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.

Antibodies are essential components of adaptive immunity. A typical antibody repertoire comprises an enormous diversity of antigen-binding specificities, which are generated by the genetic processes of recombination and mutation. Accumulating evidence suggests that the immune system can exploit additional strategies to diversify the repertoire of antigen specificities. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-019-0126-7
Publisher Site
http://dx.doi.org/10.1038/s41577-019-0126-7DOI Listing
February 2019
5 Reads

Itaconate: the poster child of metabolic reprogramming in macrophage function.

Nat Rev Immunol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage activation. The main reason macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-019-0128-5
Publisher Site
http://dx.doi.org/10.1038/s41577-019-0128-5DOI Listing
January 2019
2 Reads

Commensal cocktail for CD8s.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Jan 30. Epub 2019 Jan 30.

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0130-yDOI Listing
January 2019

Seeing through the parasites' eyes.

Nat Rev Immunol 2019 Jan 30. Epub 2019 Jan 30.

Fundação Oswaldo Cruz, Belo Horizonte, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0129-4DOI Listing
January 2019

Adaptive immune responses to primary and secondary dengue virus infections.

Nat Rev Immunol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the human population, and secondary dengue infections are common. Here, we contrast the mechanisms initiating and sustaining adaptive immune responses during primary infection with the immune pathways that are pre-existing and reactivated during secondary dengue. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-019-0123-x
Publisher Site
http://dx.doi.org/10.1038/s41577-019-0123-xDOI Listing
January 2019
8 Reads

Immunometabolism at the interface between macrophages and pathogens.

Nat Rev Immunol 2019 Jan 24. Epub 2019 Jan 24.

Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent appreciation of macrophage heterogeneity, with respect to both development and metabolism, indicates that the reality is more complex. Different lineages of tissue-resident macrophages respond divergently to microbial, environmental and immunological stimuli. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0124-9DOI Listing
January 2019

Sodium in the microenvironment regulates immune responses and tissue homeostasis.

Nat Rev Immunol 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurology, University of Regensburg, Regensburg, Germany.

During tissue inflammation, immune cells infiltrate the interstitial space of target organs, where they sense and adapt to local environmental stimuli. Such stimuli include not only pathogens but also local factors such as the levels of oxygenation, nutrients and electrolytes. An important electrolyte in this regard is sodium (Na). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0113-4
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0113-4DOI Listing
January 2019
4 Reads

Containment strategy.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb;19(2):71

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0122-yDOI Listing
February 2019
1 Read

Neuronal itaconate restricts viral infection.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb;19(2):67

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0121-zDOI Listing
February 2019
1 Read

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer.

Nat Rev Immunol 2019 Jan 15. Epub 2019 Jan 15.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

The immune system detects disturbances in homeostasis that occur during infection, sterile tissue damage and cancer. This initiates immune responses that seek to eliminate the trigger of immune activation and to re-establish homeostasis. At the same time, these mechanisms can also play a crucial role in the progression of disease. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0117-0
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0117-0DOI Listing
January 2019
12 Reads

Organismal immunometabolism: advances in both directions.

Authors:
Diane Mathis

Nat Rev Immunol 2019 Feb;19(2):83-84

Department of Immunology, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0118-zDOI Listing
February 2019
1 Read

CAR T cell therapy: inroads to response and resistance.

Nat Rev Immunol 2019 Feb;19(2):73-74

Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine, Stanford University, Stanford, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0119-yDOI Listing
February 2019
1 Read

21st century natural killers.

Authors:
Cristina M Tato

Nat Rev Immunol 2019 Feb;19(2):69

Chan Zuckerberg Biohub, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-019-0120-0DOI Listing
February 2019
2 Reads

Novel connections and precision approaches.

Nat Rev Immunol 2019 Feb;19(2):75-76

Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Department of Microbiology and Immunology, and the Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0114-3
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0114-3DOI Listing
February 2019
6 Reads

Calcium signalling in T cells.

Nat Rev Immunol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Calcium (Ca) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0110-7
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0110-7DOI Listing
January 2019
6 Reads

Poised plasticity of skin T cells.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Feb;19(2):70-71

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0116-1
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0116-1DOI Listing
February 2019
3 Reads

Microglia take centre stage in neurodegenerative disease.

Authors:
Michael T Heneka

Nat Rev Immunol 2019 Feb;19(2):79-80

Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn, Bonn, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0112-5
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0112-5DOI Listing
February 2019
15 Reads

Deciphering the gut-brain link in NEC.

Nat Rev Immunol 2019 Feb;19(2):70-71

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0115-2DOI Listing
February 2019
1 Read

Systems-level patterns emerge.

Authors:
Petter Brodin

Nat Rev Immunol 2019 Feb;19(2):87-88

Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0106-3DOI Listing
February 2019
1 Read

Trans-Golgi network breaks away to activate NLRP3.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb;19(2):68-69

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0111-6DOI Listing
February 2019
1 Read

The signposts and winding roads to immunity and inflammation.

Nat Rev Immunol 2019 Feb;19(2):81-82

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0108-1DOI Listing
February 2019
1 Read

B cells still front and centre in immunology.

Authors:
David Tarlinton

Nat Rev Immunol 2019 Feb;19(2):85-86

Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0107-2DOI Listing
February 2019
1 Read

How to train an innate response.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb;19(2):68-69

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0109-0
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0109-0DOI Listing
February 2019
8 Reads

Advancing an HIV vaccine; advancing vaccinology.

Authors:
Dennis R Burton

Nat Rev Immunol 2019 Feb;19(2):77-78

Department of Immunology and Microbiology, the Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), International AIDS Vaccine Initiative Neutralizing Antibody Center, Scripps Research, La Jolla, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0103-6DOI Listing
February 2019
1 Read

Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies.

Nat Rev Immunol 2019 Jan;19(1):63-64

Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0098-z
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0098-zDOI Listing
January 2019
7 Reads

Reply to 'Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies'.

Nat Rev Immunol 2019 Jan;19(1):65

Center for Systems Biology and Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0099-yDOI Listing
January 2019
1 Read

Radiation promotes systemic responses.

Authors:
Jordan Hindson

Nat Rev Immunol 2019 Jan;19(1)

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0102-7DOI Listing
January 2019
2 Reads

Of bugs, bones and butyrate.

Nat Rev Immunol 2019 Jan;19(1):4-5

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0104-5DOI Listing
January 2019
2 Reads

Taking the good without the bad in transplantation.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Jan;19(1):4-5

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0105-4DOI Listing
January 2019
1 Read

Fixing a hole.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Jan;19(1):2-3

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0101-8
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0101-8DOI Listing
January 2019
7 Reads

Transporters help clear cell corpses.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Jan;19(1)

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0100-9DOI Listing
January 2019
1 Read

Autophagy in the renewal, differentiation and homeostasis of immune cells.

Nat Rev Immunol 2018 Dec 7. Epub 2018 Dec 7.

Kennedy Institute of Rheumatology, University of Oxford, Headington, Oxford, UK.

Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0095-2DOI Listing
December 2018
1 Read

Targeting trained immunity.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Jan;19(1):2-3

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0097-0DOI Listing
January 2019
1 Read

Statins: a viable candidate for host-directed therapy against infectious diseases.

Nat Rev Immunol 2019 Feb;19(2):104-117

International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town-Component, Cape Town, South Africa.

Statins were first identified over 40 years ago as lipid-lowering drugs and have been remarkably effective in treating cardiovascular diseases. As research advanced, the protective effects of statins were additionally attributed to their anti-inflammatory, antioxidative, anti-thrombotic and immunomodulatory functions rather than lipid-lowering abilities alone. By promoting host defence mechanisms and inhibiting pathological inflammation, statins increase survival in human infectious diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0094-3DOI Listing
February 2019
1 Read

B1 B cells link gut dysbiosis and insulin resistance.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Jan;19(1)

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0096-1DOI Listing
January 2019
8 Reads

Models of immune selection for multi-locus antigenic diversity of pathogens.

Nat Rev Immunol 2019 Jan;19(1):55-62

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

It is well accepted that pathogens can evade recognition and elimination by the host immune system by varying their antigenic targets. Thus, it has become a truism that host immunity is a major driver and determinant of the antigenic diversity of pathogens. However, it remains puzzling how host immunity selects for antigenic diversity at the level of the pathogen population, given that hosts have acquired immune responses to multiple antigens of most pathogens - sometimes through multiple effectors of both humoral and cellular immunity. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0092-5
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0092-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352731PMC
January 2019
4 Reads

CARD-BCL-10-MALT1 signalling in protective and pathological immunity.

Nat Rev Immunol 2019 Feb;19(2):118-134

Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.

CARD protein-BCL-10-MALT1 (CBM) signalosomes are multiprotein signalling platforms that control immune and inflammatory pathways in most tissues. After exposure to distinct immune triggers, these molecules form self-organizing filaments with MALT1 protease activity to regulate canonical nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways and the degradation of mRNA-binding proteins, which provides two layers of control of inflammatory gene expression. These CBM-regulated mechanisms are essential for host defence and tissue homeostasis, and numerous genetic alterations in CBM signalling components have been implicated in inherited and acquired immune-mediated diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0087-2DOI Listing
February 2019
16 Reads

Dendritic cell subsets in T cell programming: location dictates function.

Authors:
S C Eisenbarth

Nat Rev Immunol 2019 Feb;19(2):89-103

Department of Laboratory Medicine, Immunobiology, Section of Allergy & Immunology, Yale University School of Medicine, New Haven, CT, USA.

Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity. They integrate signals derived from tissue infection or damage and present processed antigen from these sites to naive T cells in secondary lymphoid organs while also providing multiple soluble and surface-bound signals that help to guide T cell differentiation. DC-mediated tailoring of the appropriate T cell programme ensures a proper cascade of immune responses that adequately targets the insult. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0088-1DOI Listing
February 2019
45 Reads

Translational target for checkpoint inhibitors.

Authors:
Katie Kingwell

Nat Rev Immunol 2018 Dec;18(12):728-729

Associate editor, Nature Reviews Drug Discovery, .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0091-6DOI Listing
December 2018
1 Read

The immunological anatomy of the skin.

Nat Rev Immunol 2019 Jan;19(1):19-30

Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The skin is the outermost organ of the body and is continuously exposed to external pathogens. Upon inflammation, various immune cells pass through, reside in or are recruited to the skin to orchestrate diverse cutaneous immune responses. To achieve this, immune cells interact with each other and even communicate with non-immune cells, including peripheral nerves and the microbiota. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41577-018-0084-5DOI Listing
January 2019
8 Reads

Tame or inflame: gut reactions to pro- and antibiotics.

Nat Rev Immunol 2018 Dec;18(12):728-729

Nature Reviews Immunology, .

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0093-4
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0093-4DOI Listing
December 2018
10 Reads

Central CD4 T cell tolerance: deletion versus regulatory T cell differentiation.

Nat Rev Immunol 2019 Jan;19(1):7-18

Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.

The diversion of MHC class II-restricted thymocytes into the regulatory T (T) cell lineage is driven by intrathymic encounter of agonist self-antigens in a similar manner to the clonal deletion of thymocytes. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and T cells that are diverted into the T cell lineage. Here, we discuss how thymocyte-intrinsic and thymocyte-extrinsic determinants may specify the choice between these two fundamentally different T cell fates. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41577-018-0083-6
Publisher Site
http://dx.doi.org/10.1038/s41577-018-0083-6DOI Listing
January 2019
14 Reads